Dr. Harry Pantazopoulos, Ph.D. – Dr. David Rabin

The morphing structure of the brain's "cartilage cells" may regulate how memories change while you snooze, according to new research. Sleep lets the body rest, but not the brain. During sleep, the brain accounts for a day of learning by making strong memories stronger and weak memories weaker, a process known as memory consolidation. But changing memories requires changing synapses, the connections between neurons. Sleep-induced changes need to overcome perineuronal nets, cartilage-like sheaths that not only surround and protect neurons, but also prevent changes in synapses. PLUS Ever wish you could just snap out of a mood? You feel tired or anxious and wish you could snap your fingers and change your mood on demand? Well you can, sort of. You can use vibrations to change your mood, relax you before bed or energize you before a workout. Here’s how. Get Apollo Neuro and save 15% OFF http://shrnetwork.biz/apolloneuro

Circadian Rhythms of Perineuronal Net Composition https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405073/

[3:30] The inspiration behind the memory consolidation/ sleep research.

• Synaptic homeostasis hypothesis.
• The brain has a limit of synaptic connections. That it can produce. The rest need to be consolidated.
• REM sleep aids in transferring short term connections into long term consolidation.
• The brain decides which memories are strong by biological relevant weighting. (i.e how to survive and where to find food)

[10:08] Brain cartilage.

• Structural support.
• There has to be reorganization in the cartilage structure in order to form new connections.
• This cartilage is degraded by proteases that are endogenously produced in the brain.

[17:50] The definition of the term addictive.

• May be treatable by modulating the cartilage structure in the brain.

[22:20] Study design.

• Used data from post mortem brain samples.
• Time of death was used as a proxy for circadian rhythm in previous research.
• Mouse models.

[25:30] does inappropriate sleep hygiene affect the plasticity of brain cartilage?

[27;18] too much or too little cartilage expansion can result in brain disease states.

[35:12] Does inflammation play a role in degradation of cartilage in the brain?

[38:25] Impact of nutrition on brain cartilage.

• Some researchers are looking into the effects of GH in the brain.
• It strengthens memory storage.
• Intra nasal GH and BPC-157 could have good potential in this field.
• Subcutaneous GH may still get to the brain, but it is still unsure as to whether it crosses the blood brain barrier or not.

[1:11:00] What the Apollo really does.

• It encourages you to get up and do something or to relax.
• Carl is going to use his before every meal to encourage rest and digestion.
• It is not a magic bullet.
• It acts as a catalyst to shift the way that you feel.