Dr. David Nieman DRPH
Today’s interview discusses research discoveries within 4 areas of exercise immunology that have received the most attention from investigators: (1) acute and chronic effects of exercise on the immune system, (2) clinical benefits of the exercise–immune relationship, (3) nutritional influences on the immune response to exercise, and (4) the effect of exercise on immunosenescence.
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SHR # 2496 :: The Compelling Link Between Physical Activity and the Body's Defense System
Show Notes:
[3:05] 30-60 minutes of physical activity/ day reduces the rate of common cold 40-50%.
- Immune cells are recruited and circulate the body more for up to 3 hours after exercise.
[7:48] Acute and chronic effects of exercise on the immune system.
- Too much exercise can also be detrimental.
- Transient immune disfunction occurs after running a marathon.
[11:40] Glycogen depletion may be the first domino in the process of immune disfunction.
[17:11] The clinical benefit of the exercise immune relationship.
- Exercise has the strongest effect of all factors that contribute to the immune system.
- Lean, active people tend to have lower chronic inflammation.
[20:16] Nutritional influences on the immune system.
[27:29] Effects on immunosenescence.
[47:15] 1902 study done on Boston marathon runners.
- Blood cell counts looked as if they were fighting an illness.
[50:00] 1980-1989: much progress was made in understanding exercise immunology.
- Partially due to the AIDS epidemic.
[54:45] 90’s.
- There were nutritional breakthroughs.
- Super high doses of vitamin C did not seem to help.
- High vitamin E hindered the immune system.
- Carbohydrates and flavonoids augment the immune system.
[1:02:27] Can there be a hormetic response from extreme immune compensation?
[1:13:34] Only 1/2000 people are predisposed for high athletic endeavor.

