Dr. Detlev Boison PhD
Coffee has a beneficial effect on traumatic brain injury. But it’s not simple. Pre-treating and post-treating the injured brain have different effects. As well as chronic coffee consumption post TBI. Knowing what works and what doesn’t will make a world of difference to the injured person. This research also helps those who suffer from seizures and Epilepsy.
------------------------Studie
More Than Just a Cup of Coffee-
https://asc.army.mil/armyalt/J
Effects of Preinjury & Postinjury Exposure to Caffeine-
https://www.liebertpub.com/doi
Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators-
https://www.ncbi.nlm.nih.gov/p
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SHR # 2494 :: It is Not Just a Cup of Coffee: The Effects of Caffeine Pre and Post TBI
Show Notes:
[2:20] The research is based off of interest in the adenosine molecule.
- There is potential use of adenosine to treat epilepsy.
- It is released from the breakdown of ATP during energy crises.
- The accumulation of adenosine creates sleep pressure.
- It acts as an endogenous agent to stop a seizure.
[8:11] Adenosine, ketones, and caffeine.
- When a person has a TBI, they hold their breath.
- Higher levels of adenosine can lead to apnea.
[10:55] study: Can caffeine be used to treat TBI?
- Rat model of TBI.
- Caffeine caused the rats to breath after a TBI.
- The human equivalent dosage would be 4mg/kg.
[14:00] Can caffeine be used to pre-treat a TBI?
- Yes, if an acute dose is given immediately before.
- It will also work if given within 10 seconds of the injury.
[16:50] Adenosine’s role in cognitive processes.
[18:35] What about creatine?
[24:50] How would this be leveraged in epilepsy patients?
- Global boosts of adenosine leads to ethargy.
- Local adenosine can completely suppress epileptic seizures.
- Transient doses of adenosine can completely prevent epilepsy.
[29:12] how does exercise increase adenosine?
[29:43] The difference between caffeine and coffee.
- Coffee increases homocysteine more than caffeine alone.
[30:43] what about the study that was done for the military?
[33:05] Kratom?
[44:10] Could caffeine help with Covid-19?
[46:45] Adenosine as an endogenous neuroprotectant.
[49:27] what should laypeople take from your research?
- Most disorders work on multiple pathways.
- Drugs usually target only 1 pathway.
- Natural compounds should be studied more.
