[00:00:00] Carl Lanore: [00:00:00] Hey, Hey, welcome back to another episode of Superman radio it's Tuesday, which means we've got the blueprint power hour during the first hour. Uh, second hour of the show today, we're going to talk about how a brain injury, or even like a bump on your head. A good, good wallop on your head can actually seed the development of a brain tumor.

[00:00:17] This is exciting, uh, yet distressing estimation. Uh, we're going to be talking about later. Uh, I just realized I didn't put Rob's music in, so I'm dropping it in right now. Be patient with me. Um, of course, before we do anything else, we have to thank our title sponsor and that is legendary foods. Uh, right now, if you go to, uh, SHR network.biz/legendary, you can pick up a box of tasty pastries and the new birthday cake style, uh, for 10% off using the code SHR 10.

[00:00:54] Uh, plus shop around. They have great seasoned almonds. They have great nut butters that have zero sugar in [00:01:00] them. Um, if you really want to stay away from sugar, the place to do it is legendary foods. SHR network.biz/legendary, uh, is where to go and SHR tendons to code also. If you don't want to spend a penny, but you want to win a box.

[00:01:16] And we have winners, man, and everybody's excited. We're getting people who are winning. Uh, we'll start announcing the winners later this week. I'm accumulating the names, getting their addresses so we can ship them, uh, their prize. But if you want to win a box of the new birthday cake, tasty pastry, which is an unbelievable decadent tasting snack with 20 grams of protein and no sugar.

[00:01:40] All you have to do is listen for the secret word during the commercial break, email, that secret word to on This email address is being protected from spambots. You need JavaScript enabled to view it., and you're entered to win. And there's a box given away every day. So just keep doing it cause eventually you'll win. Uh, I mean we're giving away 20 a [00:02:00] week. I mean a month, five a week.

[00:02:03] Uh, so it doesn't get better than that. Check it out. Uh, and, uh, listen for the secret word. I'm getting Rob's music pulled in here. Hold on one second. Um, so the other thing I want to talk about before we get started is we're giving away five meteorites. Uh, if you go to SHR network.biz/free media or to wit to enter, uh, we're giving away five of the mile store meteors.

[00:02:29] I love this. Um, sometimes when I'm using it, People think I'm doing something suspicious because you could hear that, but this is an amazing device. It's, it's, it's a massage ball that you can use anywhere. And it has three different levels of vibration. I mean, and it's heated if you want heat. And what I do is I put it in the chair over here and I leave it right there up against lumbar spine and I pushed back on it.

[00:02:57] It just feels so good. My whole back [00:03:00] feels it. Well. This is a brilliant little device and you can win one of five. Uh, by following the instructions here and going to SHR network.biz/free media. So get in there and, uh, and, and make sure that you're, you are, uh, entered when, uh, one of five of those. And now without further delay, we will roll on with, uh, Robert gushes music.

[00:03:23] There we go. Calling all blueprint, army fall in line. It's time for the blueprint power hour with coach Rodriguez on the superhuman radio network.

[00:03:38] Are you doing Rob?

[00:03:39] Coach Rob Regish: [00:03:39] I'm doing great, man. I started a week two of getting back to the gym and, and everything seems to be healing up nicely, including this hip. So I'm hopeful next week I can open it up and, uh, and really get going. But Hey, life's good. You know,

[00:03:54] Carl Lanore: [00:03:54] I was just thinking about this. Like, my body is changing already from being consistent, just for what?

[00:03:58] Maybe three or four [00:04:00] weeks. Now I'm doing cardio in the morning. Like I'm supposed to, I feel better. I'm already getting really strong again, which is makes me happy. But the goal has to be, to do this for the rest of the year, the rest of the year injury, free interruption, free, you know, navigating the challenges of life and work and family and everything else.

[00:04:23] And do this for the next, the rest of this year. And I will be back to my best shape and conditioning ever. That's the magic. Yeah, I could do it for a couple of months. No problem. It seems like I can always do it for a couple months.

[00:04:40] Coach Rob Regish: [00:04:40] Yeah. It's uh, it's tough, man. It's been said before, and it's true. You can't be in if you can't train that's right.

[00:04:49] Carl Lanore: [00:04:49] And on that note, we have a question from Clarence Boyd. He says, what can I do to increase my speed and explosiveness? I'm really strong, but find that I'm slow when playing pickup [00:05:00] basketball with my

[00:05:00] Coach Rob Regish: [00:05:00] friends. Yeah. Um, there are a lot of guys who lift heavy and have for years and due to tightness or poor mobility.

[00:05:10] They, they lack this, uh, I'll call it first step quickness or explosiveness, however. Um, just because you lift heavy weights and you're a big guy, it doesn't mean you can't be fast and explosive. Uh, you need only look at a 300 pound plus NFL linemen that are running incredibly fast, 40 yard dashes. And that's them.

[00:05:33] I mean, the running backs are there. They're one to 25 now. Um, and they're plenty quick. They can accelerate a blistering speed. So just because you're big and strong doesn't mean you can't be fast and explosive. So that's, you know, that goes to show it's possible. So the big question is. How, how did, how was what's the best way to do this?

[00:05:56] The best tools that I've found to convert [00:06:00] strength to speed and explosiveness in no particular order are the following one, moving lighter weight faster. Nobody wants to lift light, uh, but there's a method to the madness. Number two band sprints, which I'll get into in a little bit more extensively focusing.

[00:06:19] On that first step quickness three, the standing long jump for the standing high jump. And then five, if you still have the gas lift. Um, depth jumps from boxes of various Heights, rebounding and jumping back up, uh, as quickly as you can. So-called Checkmarx strength. If you read the works of Dr. Squat, Fred Hatfield in his excellent book power going back over 30 years anyway.

[00:06:48] Um, so by all means keep lifting weights. However, I would encourage you not to lift heavy. All the time, because the [00:07:00] more weight you pile on the bar, the slower it moves. That's just a universal thing, right? Heavy weights, whatever heavy is for you, especially approaching your one rep. Max is not going to move fast.

[00:07:14] Instead. I want you to have at least one day a week where you work with 50%, just 50% of your one rep max and move that far. As fast as possible. Westside has pretty much been at the forefront of this over the years. Um, and so they apply it to the bench, the squat and the deadlift. And so here's what they do.

[00:07:38] Or at least last last I knew for the squat and Dartmouth, you want to work up to 10 to 12 sets of two repetitions. You, you re you only rest between 30 and 45 seconds between sets, but the key. Thing is to move that bar as quickly as possible. If you can do it in three reps, then do it in three. I wouldn't do [00:08:00] more than three though.

[00:08:01] Um, because speed quickly, quickly drops off for the bench press. It's eight to 10 sets of three repetitions. Uh, again with 30 to 45 seconds, uh, in between sets the band sprints. As the name implies, I guess you're sprinting with the band hooked to your, usually hooked around your belt. Uh, with the other end tethered to either a support beam, like let's say, on a power rack, uh, or a sled may be loaded with a lot of weight or a partner.

[00:08:35] The partner is actually best because he can keep you from springing back and getting flung into a, into a power rack. So. What'd you want to do here is sprint as quickly as you can out of the blocks from a dead stop and keep sprinting hard until the band of course tries to pull you back. Do not, however, try and turn [00:09:00] around.

[00:09:00] To go back because you're just asking for a knee injury. Don't ask me how I, I found that out. Um, and that's really where the partner is ideal, right? Because they can go with you a little bit and minimize any of that, that pull back the standing long jump and the standing high jump should be self-explanatory.

[00:09:21] What I do is I use a little piece of chalk and I Mark off right at the top of my. Jump and also where my heels hit in terms of the long jump you will have, and you should measure it, um, to have a reference standard, if you will, it's almost like a one rep max in weightlifting. Your goal is to, um, to obviously exceed those right.

[00:09:46] Higher and farther. So, uh, those two are excellent. Really for converting speed to strength. And then finally depth jumps, uh, are a form former [00:10:00] pliant plyometrics, right? And, and they're, they're excellent at teaching you to be explosive. They're not, you know, there are some downsides to them, but essentially they're teaching you to convert, right?

[00:10:13] All that eccentric, downward energy that's built into the muscle is then released. Right and explosive bursts and you learn real fast. You can't stay in contact with the floor very long, because if you do, you're not going to be able to rebound as high don't. I would tell you this too, don't go crazy on the box height.

[00:10:36] No more than like three feet, especially to start two is probably better for most people. Just to get the hang of it. Um, when you're at least when you're starting out. So I would do those five things. I prioritized the first three. Um, and if you still have the gas, do the last two, you should notice pretty big improvements within the first month, [00:11:00] especially on your high jump, standing high jump and standing long jump.

[00:11:04] And it's pretty cool to watch too.

[00:11:07] Carl Lanore: [00:11:07] What about the, um, what about pushing a sled? Not too heavy, but literally blasting off in sprinting with it for 20 feet at a time to create explosive, uh, strength in the legs.

[00:11:18] Coach Rob Regish: [00:11:18] Yeah, I guess, um, I never thought about that, but similar to the barbell, right? You can load it. A lot lighter.

[00:11:26] Right. And then explode with it over, you know, 10, 20, 40 yards. And wouldn't go much more than, yeah. Yeah,

[00:11:33] Carl Lanore: [00:11:33] no, no, you want it. You want to just real short blast off rest for a couple seconds to blast off. It seems like it would help a little bit. So we have a, we have a question, I don't know. And I'm just putting it up for reference any informed bovine, colostrum, uh, um, Robert I'm forgetting, did we promise to look something up?

[00:11:52] Uh, could you a little bit, what's

[00:11:54] Coach Rob Regish: [00:11:54] an a

[00:11:54] Carl Lanore: [00:11:54] Merkaba per Cobra. Yeah. , that's, that's the best. That's the best. [00:12:00] Uh, claustrum I know about, but I don't know if we promised some other research to him, so expand on your comment and we'll definitely get to it. Um, the next question comes from Mike Sharp. He says, how come I'm having trouble finding bulk beta alanine.

[00:12:15] I'm not. AST no longer makes their product. In fact, I don't think they even have capsules anymore. Same deal with a lot of other companies like Biotest is there a shortage?

[00:12:29] Coach Rob Regish: [00:12:29] No, there's no shortage. Um, the, the simple truth of the matter, unfortunately, is that beta alanine doesn't move well for most, uh, supplement companies.

[00:12:40] And so instead what they do is. They tried to include it in their pre-workouts or their intro workout. That, uh, given it helps them sell it a little bit because of the mile flushing that you get pair of Steve's. But, but

[00:12:56] Carl Lanore: [00:12:56] given, but given the fact that you have to load it, isn't that silly to [00:13:00] do that. Like that's not fair to the consumer.

[00:13:02] Coach Rob Regish: [00:13:02] Yeah. I never liked that. And, and also beta alanine is best taken with some food. Uh, so some insulin release, I don't particularly like. Uh, food, food before our workout, especially a lot of food, which makes me sleepy. And you don't want the blood in your stomach. You want it to in your muscles, but be that as it may, um, they usually combine beta alanine in their pre-workout with a, uh, uh, very high dose of caffeine.

[00:13:31] Right. Which causes these kids to think, Oh gosh,

[00:13:36] Carl Lanore: [00:13:36] I feel it. I feel it.

[00:13:38] Coach Rob Regish: [00:13:38] You can feel it. Uh, in fact, The science of beta alanine at this point is more robust than it was for creating at the same point in time. I don't think it's going to have the same tail on it for reasons I'll get into, but scientists can very clearly show muscle carnosine [00:14:00] levels rising and, and in fact, increasing in muscle do out to the third, even sometimes fourth month and beyond, uh, it's, uh, It's not a boom, you know, loading phase and you're done the week, like creatine, right.

[00:14:16] It's really, you know, being consistent and patient with it over three to four months. And then you're loaded. And the good news there is, even though it took a long time to load, it takes a long time to exit the muscle. It's not like creatine and gone in a month. Um, so it's a little perplexing, right? We have this supplement, which is rock solid in the scientific literature.

[00:14:39] You can clearly measure, you know, the benefits that is out of tabbing. If you compare that to something like tribulus. Which science has almost universally panned. At least if you're looking at right its effect on muscle growth, um, stand-alone Trib is more popular than ever, and you'll find it as a [00:15:00] standalone in many companies lineup, but, uh, you know, beta alanine is, is disappearing in most Biotest is a great example.

[00:15:08] Their first product. Almost twenty-five years ago, it was TribeX right. Tribulus product. Well, they still offer standalone TribeX if I'm not mistaken while their beta alanine product came and went and they did the time-release one, which you don't need, but for some people, they like it. Um, so we've got this really weird dynamic going on and I just pointed out because, uh, things aren't always, let's say as they seem, I never considered doing a beta alanine.

[00:15:40] Uh, solo product for various reasons. Uh, but when I, you know, when it came time to formulate sensitive, but eight years ago, I made sure beta alanine was in there. Now it's not in there for the reason that most companies put it in. And in fact, most people take it when most [00:16:00] people take it. It combines with the amino acid L histamine to form carnosine.

[00:16:07] And typically guys are taken, you know, three, six, sometimes even more grams a day. There's a little problem with that, especially if it's in your pre or intro workout. El histamine is one of the essential amino acids. You pull that or any essential amino acid out of circulation at that critical time. And, and divert it to form muscle carnosine protein synthesis takes it on chin, not once but twice.

[00:16:39] And that's why I include other things like erotic acid in there, um, to, to the armchair skeptic that might've appeared to it, right. To those in the know though it's anything, but, um, You know, I would love to see everyone take it because beyond [00:17:00] the improvements in, let's say reps that, uh, on sets that exceed one minute or activities that exceed one minute, it has some very good science on being at believe it or not an antidepressant and especially an anti-aging compound.

[00:17:19] So, you know, it is good stuff. You just need to be careful with it with when you take it. And with what the final caution on beta alanine is this, if you do a boat powder and you're tempted to load more than six grams a day, Don't because you're very quickly going to find your heart starts skipping beats due to the fact that beta alanine will displace taurine, which is one of the things that regulates heart rhythm.

[00:17:49] Carl Lanore: [00:17:49] So it sounds to me like, uh, first of all, you can buy. Bulk beta alanine. I'm This email address is being protected from spambots. You need JavaScript enabled to view it. 29 96 for a kilo, but then it sounds to me like you should [00:18:00] buy essential amino acids and taurine with it, or you probably should take the essential amino acids with your beta alanine and you're touring sometime later.

[00:18:11] Coach Rob Regish: [00:18:11] Yeah. You know, your points are well taken. I have a beef with them with that book supplements. It's another well, you know, I had an order, a big order. That was lost in the mail and they refuse to reimburse me. You know, we're talking about an order that was, uh, I want to say maybe close to 150 bucks. So they never

[00:18:36] Carl Lanore: [00:18:36] resolve it with, you

[00:18:38] Coach Rob Regish: [00:18:38] know, they basically said, you know, your Sol that, and the fact that they're  product.

[00:18:46] Was analyzed by the Institute of chemistry and plant sciences. And as Becca STEM, the world experts on that particular product and it was found to have, are you ready for this numb? None [00:19:00] detectable, no Turkey testosterone in your customer room powder. So. I'm not saying all of them.

[00:19:07] Carl Lanore: [00:19:07] Well, no, here's what I, here's what I'd like to say.

[00:19:09] Then. I think anybody listening to this show, we still talking about them around the 18 minute Mark. Somebody should forward them a link either to this video or to the audio podcast. And we'd be happy to talk to them about this. Um, if they, if they want, you know what, I'm plugging them here, but I am, I don't want to plug a company.

[00:19:27] That's selling stuff. That's bunk. So I didn't know about that, but if you can get bulk to a beta alanine somewhere legit, And you can add some EAs to it. Uh, if you're going to take it in the morning before hours, before you work out, that might make sense. And then don't forget to supplement with additional uh tureen as well.

[00:19:46] But yeah, I mean, that's kind of sad that, you know, maybe they don't know you do a podcast that the episode we get 50,000 downloads of this episode every week, right?

[00:19:56] Coach Rob Regish: [00:19:56] Yeah. There's two sides to every story. What really bothered me was I never saw [00:20:00] them.  the Turkey restaurant was brought to their attention and they never even bothered to respond.

[00:20:07] Yeah.

[00:20:07] Carl Lanore: [00:20:07] Um, I'm going to get to, uh, um, the, the question about, uh, claustrum in a second, let's get this question handled first. So Shea McCray says like you, I power lifted for many years, but I'm thinking about switching to calisthenics. Will I lose most of the muscle I gained? Also, I have a young son. If he decides to do bodyweight stuff with me, will he be able to build muscle big muscle or will he need weights

[00:20:38] Coach Rob Regish: [00:20:38] for that?

[00:20:40] Yeah. So, so first things first, you know, if you build yourself up, you know, from X hundred feet, let's say 150 pounds to over 200 pounds of mostly muscle, and you did that over, you know, years. You're not, your muscle is not going to disappear just because you're no longer lifting weights. [00:21:00] Um, you can certainly challenge them with the correct.

[00:21:03] Calisthenics personally, you know, I look at it like this, it took me 35 years, right. To, to build this and it's going to take, you know, a hell of a lot for it to come off. I'm, I'm dieting hard right now. And you know, it's tough. Um, so your muscle, I would guess is not going anywhere anytime soon. I suspect it will be.

[00:21:27] The same for most people in that situation, some might even gain muscle. How well, if you've been lifting weights for many years, right? Especially lifting heavy you've thickened, your actual muscle fibers, right? Mio fibrillar. Hyper-V. Most of that, uh, is if you're training in the rep range of three to five, maybe six, uh, up to eight reps, I wouldn't go more than eight.

[00:21:53] You know, after that, you're, you're getting into a bodybuilding range that develops the [00:22:00] thick muscle, but also great strength, right? Since so much of the strength of your strength comes from the central nervous system learning. About how to contract muscle better. It's actually developing new and reinforcing existing electrical impulses that begin in your brain, run down your spinal cord, traverse a nerve running to the muscle, telling it to contract maximum.

[00:22:28] Carl Lanore: [00:22:28] And, and, and there's, there's a, there's an aspect to this that I just like to touch on. That's that's never discussed, but when you, once you've been strong, You will always be strong because of a mechanism in the brain designed to keep people from hurting themselves with their own strength. And it's called disinhibition.

[00:22:50] So when you, when you know what it feels like to have 700 pounds on your back, you may be in your sixties and not be able to do 700 pounds again, but you're going to [00:23:00] be a lot stronger than the muscle you carry. Because your brain is already learned disinhibition. It's already learned, Hey, we've done this before.

[00:23:07] We can do it again. We've been down this road before, so that, and that serves you well as you age, because there's a lot of niggling, little things that happen as you age that most people, Oh, I got to take a pill. And you're just like, now this ain't no big deal because I know what it feels like to actually be under stress under pressure, you know?

[00:23:26] Coach Rob Regish: [00:23:26] Yeah. No, I'm glad you brought that up because it's something that I've noticed, uh, too. Uh, anyway, with respect to actually building muscle with cattle static. Yeah, it can be done. Um, but the same principles that apply with the weights apply here to your, your volume is going to need to increase a bit.

[00:23:45] There is, it's very clear that there is a threshold of mechanical work that must happen to exhaust. Not the central nervous system, but the muscle of all of its chemical energy, this is how muscle is [00:24:00] built. You exhaust it, you go home, you eat you rest. And it's super compensates by stuffing even more chemical energy in there, um, to deal with that stress if it ever occurs in the future.

[00:24:13] So, um, you're going, you can grow that way. The other half of this, though. Is eating right, eating big, uh, eating a lot overfeeding and powerlifting type training or strength training. Pretty much go hand in hand, meaning, you know, you can, you can eat another two, three inches on your stomach and it'll actually help you lift your, you know, your squat and deadlift and bench will go up.

[00:24:45] So, um, you know, they're like peanut butter and jelly body weight training though, and overeating or overfeeding does not. In fact, overeating will work against every single [00:25:00] movement in your body weight work that you perform. Some more than others. For example, the chin up where you're lifting a hundred percent of your weight versus the pushup where you're lifting maybe 65, um, the simplest way to trigger growth, right?

[00:25:17] As I said before is to exhaust the muscle of chemical energy, building more muscle. From there, you do need the requisite calories. But instead of overfeeding to the tune of 20 times body, weight and calories, I would just start at 15. And if that's not moving it up 16, maybe 17, I wouldn't go much beyond that though.

[00:25:43] Um, and I'd, I'd also watch my salt intake because you know, you eat out. And you drink enough water. You're going to see it on the scale the next day. You got to

[00:25:52] Carl Lanore: [00:25:52] feel it. If you're doing pull ups, you're going to feel

[00:25:55] Coach Rob Regish: [00:25:55] it. Yeah. Three to five pounds. Doesn't sound like a lot, but man, [00:26:00] it's a difference between, you know, a good set of chin ups and not even getting one.

[00:26:06] So, um, The the biggest problem is that without the overeating, the body's ability to put that chemical energy back into the muscle is limited. Um, it doesn't mean it's impossible, but, but it's not going to be what it is, but when you put it under the downpour, right. Body weight, tons 20 calories when you're bulking with, you know, big barbell lifts.

[00:26:31] So anyway, um, In terms of setting goals, I would say, you know, a much more reasonable solution for your son. Other than that overfeeding thing is to, to use elements of both meaning, you know, 80% weights, 20% body weight. Okay. At least in his, when he's in his teens and his twenties at a minimum. Though, [00:27:00] when it comes to that body weight work, keep the chin up and, and one.

[00:27:08] And the

[00:27:09] Carl Lanore: [00:27:09] reason I say that you dropped off after you said, keep the chin up, pick up from there, keep the chin up

[00:27:15] Coach Rob Regish: [00:27:15] and keep the chin-up at a minimum in the rotation because it keeps you honest, right? Just like we talked about, your son might put 10 pounds on in a month with the chin up. He's going to tell him real quick what that 10 pounds was made up.

[00:27:32] So, uh, you know, those things kinda show up real fast, but bottom line, both you and your son can use calisthenics to grow, um, more so you, um, because your son is young and, and, you know, while his joints are good, he can, he can make a run up the weights if he, if he so chooses.

[00:27:57] Carl Lanore: [00:27:57] Um, before we go into the break, Robert [00:28:00] Thompson said, uh, have he started newborn calf replacement, colostrum.

[00:28:04] He's purchased it at tractor supply. It's 55% protein and it's only $15 a pound. I'm going to look for a tractor supply in my area. That is really a good price. Yeah. You know, um, I, I don't know about the cleanliness of it if it's made for, um, bovine, um, but hell $15 a pound. That's like, Oh, is he saying $5 a pound?

[00:28:28] It looks like. I don't know if that's a one or an exclamation point.

[00:28:32] Coach Rob Regish: [00:28:32] Um, yeah, I mean even more so if it's standardized for growth factors and amino globulins and all that, it's not, it's

[00:28:39] Carl Lanore: [00:28:39] not going to be standardized. It's going to be bulk colostrum, but who cares? You could take more at that price. Yeah. I mean, I know for COBIT Procope was expensive.

[00:28:47] It's not, it's not $15 a pound. I could tell you that right now, I'm going to look for a tractor supply today and see if they have it in my town. I'm definitely going to give it a try cause I love color, great stuff. Um, we have to take a quick commercial [00:29:00] break. When we come back, we have a question from Earl Hebner and those of you watching live, uh, uh, you can obviously post your questions as well.

[00:29:09] You are watching and listening to the blueprint power hour, go to coach Rob ruggish.com to learn more about all of coach's work. Uh, stay tuned. We'll be right back. Welcome back. I gotta, I gotta plug something that I really, really like. Yeah. It's a company called hello, fresh. You know, I've never really been a fan of these, um, services that prepare the foods.

[00:29:38] You cook it yourself, but they send you everything. I just, for some reason, I just couldn't get my head around it, like, well, you know, I can just pick up all that stuff at the grocery myself, but it turns out like why, why he do that? It's it's it's, it's no more expensive to use HelloFresh as it is to just go shopping at your local grocery store.

[00:30:00] [00:29:59] And so when we first started talking about hello, fresh on the show, you know, they sent me a couple meals and they were like, wow, these meals are really good. Elisa said to me, wow. We had a, like an Indian style chicken dish. One night we had a gnocchi dish. Uh, I liked potato gnocchi. It's uh, you know, one of the things I will eat, um, doesn't

[00:30:19] taste

[00:30:20] Coach Rob Regish: [00:30:20] like packaged

[00:30:20] Carl Lanore: [00:30:20] food.

[00:30:21] No. Have you tried? Hello, fresh.

[00:30:23] Coach Rob Regish: [00:30:23] No, but our neighbor, um, got it for, you know, I don't know how long she's been using it. And she said, you know, this does not, it does not taste like a packaged food.

[00:30:34] Carl Lanore: [00:30:34] You know what? We signed up out of our own pocket. We're getting three meals a week now. And I got to tell you something, you know, I eat the same foods day in and day out.

[00:30:43] And I'm cool with that. Alyssa likes a little bit more spice in her life. She likes a little bit something better here and there. Um, but. Everything is in there every, like if the salad calls for cucumber tomato and bib lettuce, it's in there, everything is [00:31:00] in there. It's amazing. You open the bag up, you, you know, uh, and I add a little protein last night.

[00:31:05] We had my nephew over, so I added a little chicken to it, but we had this, uh, uh, shwarma spice chicken, I guess it's a Persian dish. I'm going to put a picture of it up. This was my dish. Everything you see on that plate came with it. The cucumbers, the, the, the shallots, the rice, everything. And it takes, uh, maybe about 35, maybe 40 minutes to prepare the meal, but it tastes like a gourmet frigging meal.

[00:31:34] It's unbelievable. Now here's some interesting stuff, uh, about HelloFresh. They are a sponsor of the show right now. And so I want to promote them. Uh, if you're a busy person and you come home and you eat the wrong foods because you don't have food to eat. Cause you couldn't go to the store because you got the kids and you got soccer and you got everything else.

[00:31:54] This is where to go. It's hellofresh.com/superhuman 10. You get [00:32:00] 10 free meals, including shipping. They have 23 different recipes each week to choose from. They have a prepared menu. They're sensitive to low carb carbs spot, a vegetarian pescatarian, anything high protein, whatever your style of eating, you will find meals and there'll be meals that will expand your eating horizons.

[00:32:22] I've never had shwarma, uh, chicken with rice before. We're going to order. Yeah, we're going to order it again. It it's so good. And it, and plus there's a great deal of gratification and making a meal with complete easy instructions. They have these instruction cards. It's so simple. You boil the rifle, your bought on the right.

[00:32:42] You do this, and these are gourmet frigging meals. They're

[00:32:46] Coach Rob Regish: [00:32:46] unbelievable. Yeah, it does Elisa do the cooking

[00:32:50] Carl Lanore: [00:32:50] right now because I'm at work. And so she knows, and we just signed up for three meals a week. Right. So it's not practical for us to do five meals a week because there's a lot of nights where we have to eat [00:33:00] on the run late because we're on the go.

[00:33:02] We do a lot of things. We're busy, we're running businesses. So. We know, we can commit to three meals a week to sit down at the table and eat them. And the prices I looked at, the prices that we're paying for these three meals. And I'm like, I would have to go to Kroger's shop around, find a recipe, look at the recipe, what to buy it's it's so simple.

[00:33:23] You get the bag, you open it up a half hour later, you're eating a gourmet meal. And your family's loving it too. So again, hello, fresh is offering my audience 10 free meals, including shipping. You can take advantage of this offer by going to hello, fresh.com/superhuman 10. Use the code superhuman 10. I'm going to put the picture back up.

[00:33:44] One more time for those of you who are, are listening to the podcast. I'm sorry, you can't see this, but look at that. I mean, seriously, that is unbelievable. And that was, that was like 30 minutes. Boom. It was on the table for three of us. It was fantastic. And I loved it so much. We're going to order the shwarma [00:34:00] spice chicken.

[00:34:01] Out of this world, exotic, delicious, easy to make again. Hello, fresh.com/superhuman 10, use the code, superhuman 10, check it out. And I'd like to hear feedback. You know, we ordered some of these meals. We really don't know what they are and then you get them and you're like, wow, this, if you got this in a restaurant, you would rave over it and you're sitting at your kitchen table.

[00:34:22] You believe it, 30 minutes later. Great stuff, great stuff. Um, so. Um, Robert Thompson said it is $15 supply. Um, it's not 100% colostrum. Uh, but claustrum is the first ingredient I believe the brand is do more. Do you Mor so I'm going to check it out. Yeah. Okay. So it's 50% colostrum and 50% powdered milk.

[00:34:47] That's probably what it is. They actually consider that second or third day colostrum first day claustrum is the only, the only thing that's 100% costumes. So that's fine. All right. So the next question comes from. [00:35:00] Earl Hebner he says, I just read about something called a German volume training. You just learned about it now has been talking about it for years now.

[00:35:09] I'm only kidding are all. I'm just kidding. Uh, they make it sound like a great way to gain mass. They even said it was the best way. I'd like to put 30 more pounds of muscle on what do you think? Should I train this way?

[00:35:23] Coach Rob Regish: [00:35:23] Yeah. Yeah. You know, um, it's interesting right there. There's always. A new crop of people that are just reading about this stuff.

[00:35:30] So to them, it's brand new. Uh, and the reality is if you've been around for a while, like you and I you've seen it come in and out of fashion, if I'm not mistaken, it was originally popularized in this country by Vince Gerardo. Uh, that would have been circa the 1950s. Okay. Uh, 20 years ago, or so maybe 25 Canadian strength coach Charles Pollock when [00:36:00] God rest his soul.

[00:36:01] Um, he brought it around again and it became popular at that point, too. If I'm not mistaken, he also. Tweaked it a little bit. Um, but it essentially right. Tends to 10 reps. So usually on big, basic exercises that result of course, in a hundred total reps and that's a lie. Okay. Consider for example, bill star here, right.

[00:36:27] Is tried and true. That's a five program. Only results in a quarter of the volume of Spearman volume tree guys, still, they grow like weeds on it. Does German volume training work. Um, you know, that's, that's a tough question to answer. Not for me. I mean, I tried it multiple times, uh, and did, did not do well on it.

[00:36:54] I, uh, I suspect. That 10 sets of 10? Well, yeah, [00:37:00] it's, it's a lot, um, of loading for the muscle and maybe a big stimulus for growth. It also results in a lot of cortisol backlash. Um, and as time went on, I actually became weaker that despite the fact that I inserted extra rest days, I mean, I pulled every trick I could out of the book and I just.

[00:37:22] Couldn't recover from those workouts. I got very rundown and once I got injured and after that, I said no more. It's not for me. Uh, now I have the opportunity to speak to many people since then that have tried it. And I would tell you that more of them had an experience like mine, uh, than people who came back raving about it.

[00:37:47] So for most people, here's, here's what I would tell you. It may be useful every now and then as a shock workout, uh, to get that, you know, grow message across to [00:38:00] your body. But I can't see people at least genetically typical people using it with any kind of regularity and growing from it. You know, most people truth be told, I think, or would grow much better.

[00:38:15] On a five by five or, you know, if you want to take things up from there, use ladders ladders, you know, one, two, three, four, or five reps spread, uh, is going to do a lot for you, right? Because if you do complete all three of those ladders, that's 60 total reps, which is in and of itself more than double of what stars five by five volume is.

[00:38:42] And, and. In my experience, it doesn't wear you down like German volume training would. Um, now it's perfectly acceptable to reverse that rep spread. So instead of doing one, two, three, four, five, you start with five reps and each [00:39:00] success of set goes down to rep mentally. It's really interesting. Mentally it's easier, or at least it seems so to sprue all three letters, but.

[00:39:11] If you do the math, right? Assuming the loading stays the same. If the total ton is just the same. So however you do it, you know, I don't care, but you know, when, when you want to increase total tonnage, that's a great way to do it. Let's get to the real answer. You say you want to gain 30 pounds of muscle.

[00:39:33] Um, here, here, here would be my first pack. I would buy the book, super squats. I wouldn't read it once. I'd read it twice. I would take it to heart and I would do it. And the reason is that simple, I didn't say easy, simple program has put more muscle on people than most other routines combined. [00:40:00] It is time tested.

[00:40:02] And when I say that it was originally written. And has been used quite successfully since the 1930s. And if you study all time strong, man, the books, you will see that that's the case. Fortunately, um, Perry Raider. Who was the owner of the original iron man magazine kind of brought 20 rep squats, you know, and milk back to the forefront.

[00:40:29] But even if you don't want to do that, like I said, five by five ladders, Charles Staley's escalating density training, uh, you know, even the loading patterns that I prescribed. I would consider all far superior to German volume training, right? At least for any consistent period of time. That's just my opinion, but I've seen a lot of people get great results with a lot less wear and tear.

[00:40:55] On those other programs. So give him a shot. You know, I'm confident one of them will [00:41:00] work for you.

[00:41:00] Carl Lanore: [00:41:00] Dr. Brad Schoenfeld will be on in February. He just published a series of new papers and he did. He puts something on Twitter last week, as a result of the papers he's published. And it said lightweight high volume builds muscle heavyweight, low volume builds muscle it's like there were three different ones and the end result is like, Th the, the thing that people need to focus on more than I kind of feel like training is like dieting, you know, they always say, well, what's the diet that you're more likely to stick to the longest, you'll see results.

[00:41:35] What's the training style. You're most likely to stick to the longest. You'll see results. If you do one thing and that's focused on progression, adding weight, adding reps, adding weight. Adding reps because it doesn't matter what you do. If you focus on progression, you're getting stronger.

[00:41:55] Coach Rob Regish: [00:41:55] Yeah. If you can do that consistently, you're going to grow the muscle.

[00:42:01] [00:42:00] Carl Lanore: [00:42:01] Uh, we're going to take, uh, our last commercial break of this segment. Uh, and come back, we have one more question to answer, and then the blueprint tip of the day. And then later in the show, we're going to be joined by Dr. Gary Bader. And we're going to talk about some research that points at previous brain injury as being the beginning of a potential tumor.

[00:42:21] This is phenomenal research. In fact, a good friend of mine and a friend of the show, uh, Andrew Scarborough, who, uh, came on my show a few years ago when he was diagnosed with brain cancer. He's an advocate for the ketogenic diet and some other things. Um, and he's a survivor. Uh, he was given. Uh, a year to live and he's, that was like four years ago.

[00:42:45] Uh, but, but I emailed him last night and I said, Andy, I'm doing this show. And he said, you know, I saw the paper and it's fascinating. And he did in fact, have a brain injury that later turned into a glioma. Blastoma I think, or [00:43:00] astrocytoma, I forget what it was, but this is really, this is really good research because there's a lot of people out there who've had brain injuries and don't think that it's, you know, Oh, I'm better.

[00:43:10] You know, my concussion went away. There's more to this story. So I'm going to talk about that at the top of the hour, stick around. We'll be right back with more. Of the blueprint power hour. Welcome back to superhuman radio. Um, Rob, I got to ask you to make this next answer short because we went over here or we could just go to the blueprint tip of the day and you can answer this question next week, whatever you want to do.

[00:43:36] Coach Rob Regish: [00:43:36] I'll keep

[00:43:37] Carl Lanore: [00:43:37] it short. Okay. So there you go. So this comes from a C broke off, Broca broke off. Uh, what's the single most dangerous supplement you can use. I ask because those are the ones which usually work and I want to take lots of them. That's the silliest thing I've ever heard. Yeah.

[00:43:53] Coach Rob Regish: [00:43:53] I don't know if he was trying to be funny, but this kind of set me off a little bit.

[00:43:58] Look, the [00:44:00] assumption itself is wrong. Right. He thinks the only products that work are dangerous. Well, I would point you to create a team as the Primo example of that's not true. Um, and, and nor do I think you need to be dabbling, certainly in things like methylated pro hormones and DNP, uh, you can either prove that to yourself, the hard way.

[00:44:23] And people have died, DNP, uh, or you can take, you can take my advice, um, you know, come at it with a much more reasonable frame of mind. And I think what you'll get out of it will be a lot more than, than what you're proposing here.

[00:44:42] Carl Lanore: [00:44:42] Yeah. Okay. And so now we move right on to, uh, the blueprint tip of the day, which is.

[00:44:49] Home gym training be where strength, training, gimmicks, uh,

[00:44:55] Coach Rob Regish: [00:44:55] you know, um, one of the off shoots of COVID-19 right has been the [00:45:00] explosion and people that are training at home, which of course brings up the issue now of a home gym. Madison Avenue knows this, of course. And it starting to show up on the TV, or it has been for awhile.

[00:45:14] Um, for many years though, they've been selling. Unsuspecting, largely well-meaning people useless gimmicks that are destined for this Springs yards, eight yard sale. So, um, look as a few examples, believe it or not in the recent past, they still have that, that, you know, that machine that had a belt around you, then that just shook you the one from the

[00:45:38] Carl Lanore: [00:45:38] 1920s that shook women side to side, and they thought that was going to make them lose body fat.

[00:45:42] Right?

[00:45:43] Coach Rob Regish: [00:45:43] Yeah. I mean, you know, you were told. I guess, look, you don't have to exert yourself

[00:45:49] Carl Lanore: [00:45:49] at all. I would, I would, I would submit that, uh, women who have a lot of adipose tissue and body fat that's loosened jiggly, that all that will [00:46:00] do is break down the collagen fibers and lead to a greater accumulation of cellulite, cellulite, wherever you want to say.

[00:46:07] I think that's a horrible idea. It's horrible

[00:46:08] Coach Rob Regish: [00:46:08] idea. Yeah. Believe it or not. That idea is still around. Um, in something called the year old plate and it does the same thing. You just, you stand on what it looks like. Uh, Dr. Scale, you press a few buttons and, and all of a sudden the plate that you're standing on vibrates.

[00:46:28] Carl Lanore: [00:46:28] Now, wait a minute. Wait a minute. Vibration plate is completely different. Quite frankly. I mean, vibrate, right? Patient plate has a place. I mean, it really does. Uh, it's been shown to help people who have, uh, neuropathic pain. Uh, that gentle vibrating, uh, it's there's different levels of frequency. There's undulating plates that seem to do like an elliptical motion versus just shaking side to side.

[00:46:53] There's a lot of good information about vibration plates. I thought you meant they actually still had the device that you put the belt around

[00:46:57] Coach Rob Regish: [00:46:57] you. Well, no, but, but it is [00:47:00] geared. It was geared at least the one I saw, but towards fat

[00:47:03] Carl Lanore: [00:47:03] loss, it's not going to, it's not going to make you lose fat. Yeah.

[00:47:06] Coach Rob Regish: [00:47:06] Yeah. Now the vibration thing doesn't end there though, right?

[00:47:11] Because somebody looked at it and said, Hey, we can apply that to muscle-building with this

[00:47:15] Carl Lanore: [00:47:15] shake await thing. It is, that is the silliest thing I've ever seen. And I think whoever foisted that exercise device on the industry did it with tongue and cheek. They were like, let's see how many stupid people we can sell this device to.

[00:47:28] And they'll look even stupider holding that thing in their hand, going like, like it's, it's. I don't even want to stop the jokes, the potential jokes about that thing.

[00:47:36] Coach Rob Regish: [00:47:36] You know what I mean? Yeah. I mean, according to the advertising, it allegedly causes up to 240 muscle contractions per minute. I don't know how they measure that, but look, if you're ever feeling down, you need a good laugh, you can visit their website.

[00:47:53] And I know, I know you're going to be entertained. Uh, In the early eighties, there was something [00:48:00] called a slim suit, which was aggressively marketed to overweight women. And so just picture tinfoil, like pants and the matching top. And you've got the slim suit in the commercials. Believe it or not on YouTube, they're still out there promising these women that they'll lose weight while watching TV, talking on the phone and even sleeping, you know, direct quote you'll wake up, weighing less every morning.

[00:48:27] Right. So I guess if you want to look like a trashcan, a steel trashcan have at it. Um, certainly, um, I think most people will remember the Bowflex. Um, which is at least the last time I looked is essentially, you know, a nice padded leather seat with what looks like 10 or so power rods, or spider legs as I call them behind it.

[00:48:54] Uh, I see a lot of these at yard sales too, I guess. It's. Have you ever had, have you [00:49:00] ever been trained? Have

[00:49:00] Carl Lanore: [00:49:00] you ever, have you ever trained on one? No. So my sister bought one. She was one of those people who, you know, for like 39, 95 a month, you can buy, it was overpriced. They went after it. They compared it to a gym membership.

[00:49:13] But I got to tell you something. If you've never tried one, you may want to try one before you pass judgment on it. It continuous tension. And the, the, and he gets it that the, the resistance becomes greater and greater. The father, you go.

[00:49:29] Coach Rob Regish: [00:49:29] Yeah, I am. I have no doubt. You can generate significant tension with those power rugs, so to speak.

[00:49:35] Yeah, I just, I don't know. Maybe it's the people ordering them. I see a disproportionate number on, you know, on sidewalks.

[00:49:42] Carl Lanore: [00:49:42] I just think, well, first of all, the thing took up ridiculous amount of room and space in your room. Number one, because it had those power rods jutting out behind you. It kind of looked like emperor Cummings, uh, uh, on flash Gordon on his, his throne.

[00:49:56] Um, but the, what they went for was [00:50:00] they could have just made a plate loaded machine and it would have worked just as good instead of those silly rods that took up so much space. I mean, uh, it was just the novelty of these stupid things sticking up behind you, the resistance, you know, that, that really what it came down to.

[00:50:14] But yeah, it took a crazy amount of room, crazy amount of room.

[00:50:18] Coach Rob Regish: [00:50:18] Yeah. So, um, and, and the newest spin on this is, uh, gosh, I forget the name of it, but it looks like a big screen TV up on your wall. And it's got a couple of lever arms that come out in a couple cables and I guess. It's along the lines of Peloton, you know, it'll give you different workouts to do so you, you're not bored, uh, the New York times as if you needed any other reason as it's evidence of lack of journalistic integrity, proudly let their endorsement and it read this machine, knew my strengths better than I did.

[00:50:59] You know, [00:51:00] what if that's really true? My advice to you would be, be to get out of the strength training game and, you know, go play darts or something because you're clearly not cut out for it. So, so look, um, none of these gimmicks are very few work, right? Very few have stood the ultimate test, which is the test of time.

[00:51:23] You want to build muscle and lose fat without a gym. You know, there's a whole school of thought that says your body is your gym. You know, you have guts gravity and a little bit of knowledge. You can build a lot of muscle and get very strong. So I would tell you to buy, read, uh, the leading books on the subject and, uh, and practice it the most you'll need in that case is usually a chin-up bar, maybe a weight vest.

[00:51:55] You know, strength is strength. [00:52:00] Depends, you know, is a 700 pound squatter and deadlines are strong. Sure. Uh, but if you ask them to do a one legged squat, you know, most of them will fall on their butts. Right. So, so the question becomes, you know, w what do you do really for, for solid. Information about training, about diet, about supplements.

[00:52:27] And obviously I would prefer, um, if you would invest in my information, not just because I think it's the best, but you know, it'll support the show too, and we're able to help a bunch of people every week and we've got great reach. So, um,

[00:52:45] Carl Lanore: [00:52:45] do you have a special, special going on right now with the blueprint

[00:52:47] Coach Rob Regish: [00:52:47] Bolton?

[00:52:48] Yeah. And the reason I bring it up is it expires, um, on January 31st it's by far the best offer, right. That, that I've ever put out there. And [00:53:00] so, you know, the question becomes, I'm sure a lot of people are still on the fence. How do I know he's got stuff that can help me? How do I know? It's all that he says it is.

[00:53:09] And how do I know if it's worth the asking price? Well, here's what I've done. You'll get the first three months for less than $5 a month, right? 1497, 99, something like that three months. Right. So right before you even do that, uh, you can get a free sample issue, which will, we'll allow you to at least to look at one issue and say, you know what, if the rest of them are like, yes, then yeah, I'm in, um, you'll get a free, fast fat loss report that I've updated with a couple of new compounds.

[00:53:44] Uh, non-stimulant compounds as it were that I think are going to surprise a few people. And the newsletter will also tell you, um, because a lot of guys love supplements, where to put your money, what works, what doesn't and [00:54:00] where to get it. And if you so choose not everybody does that. Here's the other one other thing that I, one other point I want to make, unlike almost every other newsletter out there.

[00:54:13] I accept no advertising, which means I am beholden to no one. All I need to, the only people that I'm beholding to are my subscribers, uh, and them getting more out of this then. What there, you know, what the asking price is? So through January 31st, that's what's going on. You can get three months for less than five bucks a month.

[00:54:40] Free sample issue, free, fast, fast fat loss report, and immediate access to the entire library. Over a hundred issues, 400 topics, worst case. You'll walk away with some killer knowledge stuff that will really elevate you right. To another level.

[00:54:59] Carl Lanore: [00:54:59] How do they get it? [00:55:00] How do they get it? What's the, where do they go?

[00:55:03] Coach Rob Regish: [00:55:03] They can go to my website, coach robber, I guess.com. And, uh, the, the discount code first 90 is prefilled. I think SHR five will still work. Right. Um, but we would, we would, I would love to be given the opportunity. To prove it to you. Right. So, um, please do that before the end of the month and, and, uh, hopefully you come on board.

[00:55:28] Carl Lanore: [00:55:28] There you go. Coach. Rob rogers.com go there today. Be stronger tomorrow. We're going to take one quick commercial break. We're going to be joined by Dr. Gary Bader to talk about this fascinating research on the incidents of brain injury and the occurrence of brain cancer. Stay tuned. You're listening to and watching superhuman radio.

[00:55:48] We'll be right back. Welcome back to super Yuma radio with joined by Dr. Gary Bader. How are you doing, uh, you want me to call you Gary? So I'm going to call you Gary. Otherwise [00:56:00] I'd refer to you as Dr. Bader. I don't want, I don't want my audience to think I'm really casual, you know, because you know, every now and then there's a study that.

[00:56:07] I, I read a lot of papers and we do four to five shows a week, so it has to be good content. And, um, Alyssa sent me this study. I was like, Oh wow. Because, um, there are so many potentials for brain trauma today. Uh, in fact, I don't know if you're aware of this, but those old dental machines that used to go around your head to take the full jaw pictures.

[00:56:36] They have now been linked to different forms of TBI that cause a hypothalamus and pituitary malfunction. So when we talk about the brain, it's really delicate and you're in your work shows that. Brain injury may actually precede brain cancer. I was like, Oh my God, we have to talk about this. Why this study, uh, Dr.

[00:56:56] Gary, what, what, what preceded your work, uh, [00:57:00] other colleagues or your work that made this, uh, this, uh, study important?

[00:57:05] Dr. Gary Bader: [00:57:05] So, uh, thanks for having me on the show, Carl, um, the, uh, um, the real thing that we're trying to do here is trying to understand glioblastoma. So glioblastoma is the. Uh, most common form of adult brain cancer.

[00:57:21] Um, it's the also the most serious has a, it's a terrible disease. Um, probably, you know, when you think about putting cancer, I think everybody agrees that it's not a good thing. Um, glioblastoma as though the worst of the worst in terms of brain cancers, um, You know, you've probably heard of some things, people, uh, dying from glioblastoma, John McCain, uh, but Biden, uh, gene Siskel from Cisco and Lubert.

[00:57:46] Um, and, um, you know, it, it affects, uh, you know, there's about 23,000 cases of brain, um, 23,000 cases of brain cancer a year in the States. Um, [00:58:00] and uh, about 17,000 deaths. Um, so. There's quite a lot of people effected. Um, so because it's such a serious disease, we really want to try and find out what's the bottom of it and try to make a better therapies.

[00:58:15] Right now, there aren't really any good therapies for this disease. The five-year survival rate is less than 5%. So some people do survive longer, uh, which is, which is great. But, um, you know, if you don't have any. Uh, treatment for this disease, you probably have three to four months, uh, to, to live. Um, the basic type of treatment is surgery and radiation and, um, you know, that.

[00:58:43] Extensor the average life span of the patient to about 12 months, about a year. And there's one drug that is used in all these patients, uh, it's called temozolomide and it's, uh, you know, damages, DNA and tries to, you know, destroy the [00:59:00] cancer cells. Um, and that extends the, the average life span of three weeks, four months.

[00:59:05] So on the whole, you know, Wildridge, you know, the average, uh, Lifespan of somebody whose diagnosis is about 15 months. Um,

[00:59:14] Carl Lanore: [00:59:14] which in fact, in fact, isn't it true that in some cases, radiation, either in most cases, radiation has very little effect and in some cases may actually, uh, agitate, uh, the tumors growth.

[00:59:29] So that's a,

[00:59:30] Dr. Gary Bader: [00:59:30] that's a great question. I think that's the kind of thing that we're hoping to understand. Um, you know, a lot of, a lot of, uh, cancer treatment destroys the tries to destroy this tissue. Right? If you have cancer, you want to kill it. You want to get out of your body. So when we turn to surgery and radiation is a good way of killing cells, and if it's focused on the cancer cells can really work and actually.

[00:59:53] Um, you know, frequently that's, that's makes a big difference, but we don't know the effects of those [01:00:00] treatments and it would be better if we could find drugs that more carefully target the tumor cells and just kill them specifically because as you know, surgery, radiation causes injury to other cells and it can make, can make it worse.

[01:00:14] Um, it's well known that radiation causes mutations and it could cause the two, uh, Various types of cancer to come back, even worse. Um, so ideally we would work towards better understanding of these tumors so that we can identify drugs that are more specific and just kill the cancer cells or stop it before it starts.

[01:00:35] And then we don't have to. Yes, radiation and surgery, which are damaging.

[01:00:39] Carl Lanore: [01:00:39] You mentioned earlier that, uh, Andrew Scarborough is a personal friend of mine. He's also a friend of the show and he actually appeared on my show a few years ago when he beat his brain cancer. And he, and, and actually, uh, I stand corrected.

[01:00:51] He's watching the show live. He's gone on to, to go to university. I think he's at the college of London, uh, training as a physician to, to, to work in, in [01:01:00] brain cancer. But he posted this to me and I just want to put this up, um, It's two different things. He said, he said, uh, uh, he, he, that he read your research.

[01:01:11] He said his cancer may have risen from a cavernous. Hey meningioma. I don't know what that is, which underwent malignant transformation over time. So he's keen to listen. He said, uh, when he was discharged, uh, from brain surgery, it actually said a cavernous hemangioma, AKA cavernous angioma. Uh, but the histo histo pathology came back as high grade glioma with a high K score.

[01:01:37] It's very rare for a cavernoma to become malignant, but it does happen. And when it happens, Uh, he, he wrote in another, uh, that I'm paraphrasing now when it happens, the, uh, the prognosis is very bad because you have all of this amazing blood flow, uh, to feed the cancer. How did you guys come out? How did you, what pointed you at this?

[01:01:58] Did you do, uh, a [01:02:00] review of, of a variety of cases where there was documented head injury and documented cancer? How did you discover this?

[01:02:08] Dr. Gary Bader: [01:02:08] So that, that's a very question. We, we discovered this by really trying to understand the fundamentals of this tumor. And when we looked at the data with new technologies that we have access to, uh, we discovered that there the strongest signal and this data was a lunar response signal, and that was not really known for people.

[01:02:29] Suspected this a little bit. And it started to be, uh, seen in other cancers. Um, but we, we think that we stumble across some fundamental biology that is telling us how these tumors create our, our, our, our custom. Now it's not, it's important to, um, just for me to be clear about, it's not just that you're not going to get a tumor from getting a brain injury.

[01:02:54] There's. Millions of people who have traumatic brain injury a year. I think, you know, at [01:03:00] least almost 3 million people a year have some kind of brain injury or concussion. And we don't see 3 million, we see 20,000 or something like

[01:03:09] Carl Lanore: [01:03:09] that question is what is, what is different? That's the question. So what's actually happening to them versus the other 2,999,000 whatever.

[01:03:19] Yeah, exactly.

[01:03:20] Dr. Gary Bader: [01:03:20] So we think that it's a combination of two things. One is that you have some mutations that predispose you it's basically, he, you know, I, I, I wrote the last phrase of the thing that you just, the quote that you just put up. I was very unlucky and I think that sums it up. There's random mutations that affect of rate that, that affect us over aging in our cells and our tissue.

[01:03:45] So as we age, we build up mutations and we don't know a lot about how these mutations work, but increasingly in recent years, we've we know we're starting to uncover more and more of them. And I think that's going to be. That knowledge that we're getting about, [01:04:00] how the mutations arise in our body over time is going to be, uh, give us a lot more insight into aging processes.

[01:04:07] And you can think of cancer in adults as an aging related process. You know, young people that, you know, cancer there's pediatric cancers, but most. Uh, adult cancers are associated with older age. Um, and it's, it's the combination of these mutations building up over age, um, as our body's functioning of our lives and additional things that we think might be happening.

[01:04:31] So in our case, there might be a mutation rarely, and the, just the light part of the brain and the right type of cell, and then an injury causes it to. Become cancerous. So the way we're thinking about this is that, you know, if, if you want to, if for, for cancer to grow, you need to have cells that grow and cells grow.

[01:04:51] They can grow in size, but they can also the main way that that cancer grows through cell division. Right? So, um, you know, when we're, [01:05:00] when we're growing as a AB uh, our cells are dividing and building up our bodies and eventually we get become adults and then ourselves. Mostly don't divide, um, except for certain, certain parts of our body like blood.

[01:05:15] And, um, for the most part, a lot of our cells are fairly stable. And, um, you know, if, if we get wounded though, we had our skin and those cells have to grow again to repair that wound. Then the cells, the cell division process turns on again. And, um, normally what happens if you're wounded? Is once you're finished.

[01:05:39] Once the wound is finished being repaired, the cell stop dividing. There's a signal that they know that they can see in, in, in, in the tissue that they know. Okay, now's the time to stop. And what we think is happening here is that the mutations that might build up over time. Prevent that stuff mechanism prevent [01:06:00] those breaks from turning on at the right time.

[01:06:02] So instead of the wounds response, turning on to repair the damage and then turning off, it just keeps on trying to repair the damage. And that generates more and more tissue. Imagine if your, if your skin is repairing itself and it just never stopped and it just kept on growing basically. So that's what we think is happening.

[01:06:22] And that's a different way of thinking about cancer than people have.

[01:06:27] Carl Lanore: [01:06:27] So, so, um, do you, do you even have an idea of what this mutation is at this point in time? And it does another question I want to ask you, but I'm just curious if you have like, any idea what this mutation is yet.

[01:06:37] Dr. Gary Bader: [01:06:37] Yeah, so fortunately, uh, over the past 10 years, um, you know, since the human genome project people have.

[01:06:44] Sequence the DNA of lots of thousands and thousands of cancers. And what's come out of that. Work is big global efforts is to understand the mutations that are, that are common in cancer and in many different cancers, these mutations have been mapped [01:07:00] and we know quite a lot about them. Uh, we can look at these mutations and we can say, okay, this is the most common form of cancer that this pattern of mutations we see over and over again, the most common forms of cancer.

[01:07:10] And here's another mutation that's. Rare, but maybe it's a slightly different type of cancer, different type of glioblastoma. And so that, you know, we've started figuring out a lot more precise types of cancer. And, um, each one's probably at some. Biological story. But, um, that, that, part's pretty clear.

[01:07:30] That's correct. That, uh, the advance that we have now with new technologies is that we can go and look at these mutations in individual cells. We couldn't do that before 10 years ago. It was not really easy to look at these mutations in individual cells or look at their approximate individual cells. And yeah.

[01:07:48] You know, just in the past five years that are brand new texture scientific technologies that allow us to do that

[01:07:53] Carl Lanore: [01:07:53] from the first time. So the reason I asked this is, you know, we we've learned a lot from twin studies, like Brocka twin [01:08:00] studies, one gets breast cancer, one that does it, which makes the epigenome much more fascinating today.

[01:08:06] So I'm, I'm, I'm willing to bet there's, there's a large number of people out there, uh, that have, have the mutation and have suffered brain injuries. But never developed brain cancer, which would then make you say, well, something is triggering something is, is playing a role and maybe it's more controllable than the mutation, right?

[01:08:26] We can't change your mutated genes. But maybe from the epigenetic side, we can keep you from developing brain cancer. So my next question would be, do we know anything about the metabolic status of people who seem to have the mutation and then develop brain cancer after an injury? Are they by and large the average, you know, type two diabetic or, or, you know, do they have other comorbidities that kind of go, Oh, wait a minute.

[01:08:51] There's something else working here.

[01:08:54] Dr. Gary Bader: [01:08:54] So those are interesting questions. Unfortunately, we don't know the answer to those questions. The, and the reason is because this is too [01:09:00] new. Uh, those are questions that come out of our work and totalism is very important. Uh, epigenetics is, is definitely important in cancer.

[01:09:08] Um, comorbidities with other types of diseases is something that, um, is. Seeing them on, in the aging and aging research where people have a lot of information because, you know, everybody ages, we have millions of patients coming through the healthcare system. We can collect a lot of information about co-morbidities, but for cancer, it's harder to collect all that information.

[01:09:33] Right. Um, and also it's, it's, it's a new, these are new questions, right? So, um, We don't have the answers yet, but I think the, uh, thinking about the, these fundamental biological systems, like the system of wound healing now wound healing has got to be one of the most fundamental carts of our body. Right. Um, you could imagine, you know, every animal on the planet has to have wound healing, otherwise they wouldn't survive.

[01:09:59] Right? Yeah. So it's, [01:10:00] it's an important thing, but we don't know a lot about it actually, how it works. Um, and. Uh, we're, we're starting to learn more about it and to have it connected, to have regeneration or wound healing connected with cancer. Sort of highlights the importance of understanding that fundamental biological system.

[01:10:17] And then we can say, well, epigenetics, be tablets on these other things are important in wound healing and you know, how can that go wrong? Um, and maybe cause cancer. Now, we're also not saying that this is what, the only way of causing cancer, right? We've seen this, we think that this is happening and the major subtype of glioblastoma possible that it doesn't happen to some other subtypes where it's possible that there's.

[01:10:41] There are other ways of, of the same thing happening in the end. And we now have to look at more patients to figure out right. Um,

[01:10:49] Carl Lanore: [01:10:49] general Alyssa is kind of connect the dots. I keep coming back. I've had a Dr. Thomas C fried on the show a couple of times. I don't know if you're familiar with who he is, but he's [01:11:00] written a fascinating book called the cancer as a metabolic disease.

[01:11:03] Are you familiar with him? So, you know, he's, uh, he's, uh, he's, the mitochondria goes bad first and that's what causes the, the gene, uh, uncle genes to switch on. And, um, and, and his, his, his, uh, approach to this as a, the inflammatory response on a cellular level. So since part of the healing process is inflammation, but the inflammation is supposed to resolve.

[01:11:29] Uh, inflammation is doing a lot of work at, you know, telling growth factors and all these things to come over here and work on this. Let's get it put back to normal. And as you point out, then at some point it stops. And that is considered the resolution of inflammation and the healing process. Is it possible that pro-inflammatory mediators are actually at work that, uh, keeping these cells dividing and saying, no, you're not done yet.

[01:11:55] You know, we still have more work to do. And because there's a lot of, lot of [01:12:00] things that cause inflammation in the brain and in the body, uh, excessive iron, uh, Dr. Dale Bredesen talks about wet and dry, uh, Alzheimer's disease. We know. Uh, the gut plays a role. What about the inflammatory process and its role in this, in, in these types of cancers?

[01:12:16] Dr. Gary Bader: [01:12:16] So great question. Inflammation is a key part of this. Um, the, in the, as you said, the wound response pathway is inflammation. And usually what that means, that's called the immune system by calling nine one one come over here, uh, you know, fixed, you know, attack the bacteria that might be in there causing inflammation, or if it's, uh, a tissue damage clean up the clean up the damaged cells, right.

[01:12:40] Eat them up and recycle them. Um, on the other hand, you have to have some new cells. Just being generated to make the new tissue. Right? So it's wound healing is the combination of those two things, inflammation and new tissue generation. Um, so inflammation is critical. And the first time, you know, [01:13:00] we, we, uh, as the first time we looked at our data and we discovered inflammation, it looks like it's a key part of this, this, uh, uh, process.

[01:13:09] The first thing I thought about it was maybe. Surgery is actually harming, causing this to get worse, or maybe during surgery, we should put anti-inflammatory drugs in there. Um, and so th those are the exact experiments that we're following up on.

[01:13:24] Carl Lanore: [01:13:24] Can you, can you assess the, uh, load of senescent cells in the brain at this point in time?

[01:13:30] I keep thinking about Dr. McKell blackest Kloni. Who's also been a frequent guest on the show and, you know, senescent cells. Are they, they make inflammatory cytokines, like, like it's going out of business and, and, and we know that cancer is a disease of aging. Uh, and the more senescent cells you have, the more inflammation you have inflammation.

[01:13:52] What about if we look at the brain and go, wow. Uh, there's a high load of senescent cells. There's lots of things [01:14:00] we can do to really reduce senescence cells now. I mean, there's a couple, uh, antibiotics, um, Zithromycin has been shown, it's been approved by the FDA to re reduce 70% of the senescent spells cells in the body in fi in five days.

[01:14:15] How about senescent cell load and it as a component of the pro-inflammatory process.

[01:14:22] Dr. Gary Bader: [01:14:22] So senescence that was clearly important as well. Uh, the influence inflammation signals, the growth factors. The ones that we see are exactly the ones that are associated with this senescent cell response that you talk about.

[01:14:34] Those senescence associated secondary phenotype for SAS, we might've heard of it is these senescent cells are regenerating as inflammation. We don't know a lot about how that works. There's another, uh, senescent cells are. Don't they don't divide. Um, we don't know why they're generating these inflammation signals.

[01:14:52] It's something to do with aging. Um, and, uh, you know, we don't know what the balance is of whether, you know, what's normal and what's abnormal. [01:15:00] There's other types of cells that are quiet. Uh, they're called quiescent might be, might look the same. Uh, so we're studying those. So my colleague, Peter Dirks, um, who's a neurosurgeon in Toronto who, who, uh, Is the leader in this area that we've been working with a charter Pew who did a lot of the technology development on this project.

[01:15:20] Um, that's one of the next projects we're studying is this quiescence because it it's, um, uh, th the difference, you know, if the cells are quiescent or senescent, they're not growing. Um, but if they're somehow switching to a growth mode, or if they're telling other cells to switch into growth mode, it could be the, it could be an important part of the trigger.

[01:15:41] Carl Lanore: [01:15:41] Yeah, well, that, that, that, that's what I'm, uh, uh, that was my supposition. It's not the, they're not the senescent cell that is becoming, uh, the tumor, but we know that senescent cells make the cells around them sick by pro-inflammatory cytokines. And they may be [01:16:00] the ones that were injured and they're the ones that start dividing and dividing and dividing.

[01:16:06] So. It's not the senescent cells becoming the tumor, but the senescent cells stimulating that type of tissue to become tumorigenic

[01:16:15] Dr. Gary Bader: [01:16:15] right. And, you know, versus really getting to the core of our study. I haven't mentioned it before, but the, um, not every cell in a tumor is the same, um, there's multiple different types of cells.

[01:16:27] And in particular, Peter Dirks, Dr. Peter jerks, who I mentioned, discovered about 15 years ago. Brain tumor STEM cells and these brain tumor STEM cells are really the root of the tumor. If you take tumor cells that are not STEM cells and you put them into a mouse, they won't grow. But if you take a few of these.

[01:16:47] STEM cells, these tumor STEM cells, you put them to a mouse, it creates a new tumor. So those are the root of the tumor. And that's normally, um, you know, we think of these things as quiescent or even [01:17:00] senescent and they're they're related to the STEM cell nature of them. But what we found is that the STEM cells are actually in expressing inflammation, inflammatory pathways, which has found as a big new, new straps because we inflammatory pathways.

[01:17:16] Being turned on by Sonesta. Are there types of styles, the immune cells that come in, um, but the STEM cells themselves are calling the new system, turning on the new system. And, uh, that's that new piece of evidence kind of, um, tells us that this. You know, all of the cells that are competing with each other, this ecosystem of cells, as I like to call it, it's more complicated than we suspected.

[01:17:42] But now that we know that the STEM cells themselves are kind of turning on the immune system leaving and they would find cherry process, we can really start thinking about how to target those and understand the relationships of that to the

[01:17:55] Carl Lanore: [01:17:55] muscle cells. Are these actually. Tumor STEM cells or these STEM [01:18:00] cells that have kind of gone rogue and become a part of the process of growing a tumor.

[01:18:07] Dr. Gary Bader: [01:18:07] Yeah, there, we call them STEM like girls. Uh, we know that they have STEM cell properties, which is they can defied and become other cells and they can also self brigade. So they regenerate themselves. Those are the hallmarks of STEM for most. When we hear STEM cells, we think about, uh, development, like in a, in a, you know, Developing body and STEM cells are, are growing.

[01:18:30] We also can think about regeneration because there are STEM cells active in our adult body that, uh, people think might be important for turning on, uh, regenerative processes. Um, but actually what we think is happening in the, in the brain and people are starting to discover is that. Some cells that we never thought of, of STEM cell thought of as STEM cells for STEM, like cells in the wound response setting actually turn into STEM cells.

[01:18:57] So there are adult cells like astrocytes and they [01:19:00] differentiate that go backwards and become more primitive STEM cells. And then they, then they turn on, uh, pathways that start regenerating other cells. So you actually, um, can get w you know, Historically, or traditionally people have thought that the STEM cells give rise to everything, but now we can see that actually there certain adult cells that can turn into STEM cells, um, and that's really new and interesting information and it makes it a lot more complicated for us to think about.

[01:19:31] So, um, you know, we, we know that they have stone light properties, but whether they're STEM cells, the same as the STEM cells. Crater the tissue in the first place, or there are other cells that are, uh, you know, can do surprising things that we just didn't know about because we never thought to look at them in the context of fluid response.

[01:19:49] Um, I think it's the ladder. This, the evidence is coming out. That sort of seems like it's much more, much more, uh, interesting than we previously suspect.

[01:19:59] Carl Lanore: [01:19:59] This is [01:20:00] fascinating. I mean, so many things are going through my head. Most of them probably are. Uh, not really, uh, a part of the discussion, but we've learned so much about, um, a certain fraction of what may get three fatty acids that are pro resolving mediators.

[01:20:14] And they're being used to treat rheumatoid arthritis and other disorders that are inflammatory in nature. Uh, we also know that I just did a show about different disease States. And the levels of, of uh omega-threes and, and the body. And I think Omega three, I correct me if I'm wrong, but I think make it threes play a large role in brain tissue.

[01:20:37] Is, is that, is that, is that true?

[01:20:39] Dr. Gary Bader: [01:20:39] As far as I understand, but I've never studied

[01:20:41] Carl Lanore: [01:20:41] it, so I'm not an expert. I'm just wondering, like, I'm thinking, I wonder if these people are deficient in Omega threes and say they don't have that because the pro resolving mediators make inflammation, do its job and then stop.

[01:20:53] They resolve it, just fascinating stuff. This is really, really amazing. Um, I commend you on this [01:21:00] work and I can't wait to see what comes out next. I mean, I, a lot of the questions we've talked about are things that you and your team will be working on. Uh, so it's going to be really, really fascinating to see what you learn over the next few years.

[01:21:13] Thank you very much.

[01:21:14] Dr. Gary Bader: [01:21:14] Our big, our big goal is to try and find

[01:21:16] Carl Lanore: [01:21:16] therapies. Yeah. Fascinating. Listen, thank you so much for being here today. Dr. Bader.

[01:21:21] Dr. Gary Bader: [01:21:21] Thanks for having me on the shirts.

[01:21:23] Carl Lanore: [01:21:23] Take care. Okay. That's it. For today? Uh, lane Norton is joining us tomorrow. That's going to be a fascinating interview. Lane is very opinionated, uh, and, uh, has a huge following.

[01:21:34] And so that should be, uh, an interesting interview. Uh, don't forget, two different commercial breaks today. The secret word played. And if you heard it. Uh, you just have to write it down in an email and send it to on This email address is being protected from spambots. You need JavaScript enabled to view it. to be entered, to win a box of the new, uh, birthday cake style, tasty pastries from legendary foods.

[01:21:57] Uh, we're giving away a box of J your odds are good. [01:22:00] So take a moment. If you. Happened to be ignoring the commercials. Uh, uh, we had two different breaks that the secret word appeared in. Uh, check that out. Yeah, that's it for today. Oh, also don't forget Friday. The return after, I don't know. I think it was four or five years that we haven't done casual Friday.

[01:22:16] Um, the return of casual Friday, this Friday. If you want to send us, uh, topics or questions or comments, please send them to casual This email address is being protected from spambots. You need JavaScript enabled to view it., hel uh, wish Alyssa, a a, a great return. She hasn't been on the air with me for quite a long time. Uh, and we will be doing one casual Friday a month.

[01:22:36] That'll be the last Friday of every month. Uh, so those of you who have been bugging me and saying, we miss casual Friday, bring it back. It is back. And, uh, that's it for today. We'll see you tomorrow with more superhuman radio. Don't forget. Share the show, help somebody out, share the show. We'll see you tomorrow. [01:23:00] .