[00:00:00] Carl Lanore: [00:00:00] hey, welcome back to another episode of superhuman radio. Today is October 9th, 2019. For those of you listening to the show a hundred years from now realizing that everybody in this audience was a lot smarter than the general population. Just want to mention one thing before we start the ReNew Life RX show with Ronnie Milo and just a.

[00:00:20] I'm on vacation next week, but I've dug down deep and where we running some shows that show that this podcast is way ahead of the curve the original interview I did with dr. Michelle blackest Colonia 2010 nine years ago. About rapamycin as an anti-aging drug the whole discussion about mtor and ampk way ahead of the Curve.

[00:00:50] The original show about raw food eating that flipped everybody on their ear because they told her about raw vegan time that we talked about raw [00:01:00] chicken raw fish raw meat Randy Roach and Joshua Trenton. Joshua Trenton came on and said eating raw meats is as productive as anabolic steroids when training the original show that we did with dr.

[00:01:18] Mal di Pasquale. Where everybody flipped out when he said no post-workout carbohydrates to improve and increase the length of time that you remain anabolic that show I think was from. Two thousand and seven or eight originally rerunning the original show on blood donations eliminate cancers and heart disease in humans, man.

[00:01:53] I got some great shows this week. This coming weekend for those of you who've heard them in the past. [00:02:00] I mean, these shows are all 10 years old and older for those of you who heard them in the past. It's worth listening to the began to kind of re invest in these Concepts that still survive today and then of course.

[00:02:15] There's a lot of new listeners who haven't had the chance to listen to those shows. So they will be airing all week long and Eliza and I are taking our vacation actually for her birthday, and I'm looking forward to being away from. Little while and without further delay. Let's get Ronnie and his handsome mug the first step to changing your life starts with the ReNew Life Show with Adam Lamb.

[00:02:41] Ronnie Milo: [00:02:41] I'm

[00:02:41] Carl Lanore: [00:02:41] going to change that eventually. I'm going to have Ronnie Milo once once Adam says he's not doing the show anymore.  How you.

[00:02:52] Ronnie Milo: [00:02:52] Good good, how you doing? It's funny that you mentioned that show about raw evening is actually back in the day. I listen to that and we email you questions and I [00:03:00] emailed you a question the answer down there remember that

[00:03:02] Carl Lanore: [00:03:02] so so interesting, you know, that's the show where Randy Roach admitted Randy's blind.

[00:03:09] He's a raw food eater. And that's the show. I got the most emails people sending me emails and saying did he say he left the chicken breast out on the counter overnight and then ate it the next day. Yeah.

[00:03:22] Ronnie Milo: [00:03:22] Remember that

[00:03:22] Carl Lanore: [00:03:22] didn't get sick.

[00:03:24] Ronnie Milo: [00:03:24] Yeah. Yeah. Those are great shows on the great shows

[00:03:26] Carl Lanore: [00:03:26] groundbreaking shows.

[00:03:27] I mean these shows were so way ahead of the curve and the whole discussion with dr. Depasquale where he's actually talking about ketosis. And and Ketone levels extending the anabolic window don't have carbs post-workout extend the anabolic window literally for hours and hours your glycogen restores.

[00:03:48] Anyway overnight. No.

[00:03:50] Ronnie Milo: [00:03:50] Yeah, sometimes I go back and listen to the old yells.

[00:03:53] Carl Lanore: [00:03:53] Yeah, a Peta people will like insane about well you you know, you've got to have 80 grams of dextrose with your protein [00:04:00] powder and not you really know.

[00:04:01] Ronnie Milo: [00:04:01] Yo Bro Science.

[00:04:03] Carl Lanore: [00:04:03] Yeah, that stuff is also this is some really really great shows coming up next week.

[00:04:08] I hope people enjoy listening to them again. So the this is really a really interesting discussion. I want to preface it by saying that I had dr. Scott Stephenson on the show, either beginning of this year or end of last year where he came on and talked about the kind of dispel this whole free Androgen theory.

[00:04:27] He said, you know, The medical office oxy only pays attention to the Unbound sex hormones testosterone DHT and so on even estrogens that if once it's bound up by sex hormone-binding Goblin globulin the medical office oxy kind of acts like that's just not does it it doesn't count because it it's.

[00:04:51] It's not biologically active. That's the word they like right? So they only pay attention the free testosterone and Scott came on and said there's more going on [00:05:00] here. I think it's a mistake to ignore total testosterone just because it's bound up doesn't mean that the body is and using it. He talked about some evidence that pointed to his.

[00:05:12] That that that is actually being facility used in tissue lo and behold Adam Lamb sent us both a study yesterday that not only shows that this is true, but actually identifies the protein responsible for making sex steroids that are bound to sex hormone-binding globulin active in tissue. Fantastic talk.

[00:05:36] Ronnie Milo: [00:05:36] Yeah, so I mean so I renew life we try to really, you know, push the threshold on educating ourselves to educate a customer on optimization of hormones and there's you know to your point there's a lot of different mechanisms action that goes on in hormone production. Right? So the one thing that Adam sent over was a study which was really intuitive was the study on Megalodon [00:06:00] megillah.

[00:06:00] And mega Lynn is an endo cytokine receptor for cellular uptake of sexual steroids shbg complexes. So what that is, is it responsible for testosterone combined with shbg to bind to Megalodon to get into the cell to create endocytosis to start transcription activation of the testosterone or any sexual hormone binding globulin also to advise to 17 beta estradiol.

[00:06:28] To as they Fiji for the same mechanism of action. Now what happens is if there's high shbg or high testosterone and the Megalodon is not active. It can't get into the into the cell area for for transcription Activation. So

[00:06:42] Carl Lanore: [00:06:42] I didn't in fact knock out Knock Out rodents that have both both pairs knocked out of the the genetic.

[00:06:56] Producers of LR p21 [00:07:00] Megalodon the females have blocked what's called blockade of the vagina the vagina never opens up completely, right and the males are called cryptorchidism, which is failure for testicles to drop now cryptorchidism has been tied to DHT.

[00:07:22] as has. Vaginal blocking so DHT is responsible for turning the genitalia into male genitalia. And so what's happening and I'm sorry an estrogen for female. And and so what's happening is the lack of production the complete lack of production of megillah Noel rp2. Deactivates tissues ability to use DHT even in the presence of DHT in the bloodstream.

[00:07:55] It doesn't become activated and keep in mind [00:08:00] lrp to only works on bound sex steroids. It's not it's not working on the free stuff. It's only working on the bound sex steroids, which totally totally. Obliterates this notion that the medical Orthodoxy has that. Oh well bound testosterone and bound estrogen.

[00:08:19] They they're just of no consequence because they're not by like logically I they are biologically active this proves

[00:08:26] Ronnie Milo: [00:08:26] it right? So that's another piece of the puzzle to complete the process, right? You can use it an endogenous Mount or exogenous Mount of testosterone and if it's not creating into that Mega limb, that's not getting into the cell area.

[00:08:39] It's not able to start with during transcription Activation. So therefore it's being bound up somewhere or it's not being utilized correctly. So you can be taken, you know, 200 milligrams of testosterone or whatever. You may be taking over-the-counter if it's not transcripting into the megillah.

[00:08:55] Then it's not active at all

[00:08:58] Carl Lanore: [00:08:58] and interestingly enough double [00:09:00] knockout rodents that don't produce any megalith usually die very quickly number one, but the ones that do live show dramatic examples of rickets, and that's because Mega Lynn also affects other fat-soluble we call them vitamins, but they're actually hormones 25 hydroxy and retinol.

[00:09:24] Now talk about that. That's a that's a reciprocal relationship. Right? So if you don't have enough vitamin D, you'll actually produce less Magdalene, right?

[00:09:33] Ronnie Milo: [00:09:33] Yeah, so we see a lot if you have vitamin D deficiency, you'll see that decrease of megillah. And so what happens is there's not able to complete the process again, and I've seen probably the last four or five years about 95% people are vitamin D deficient.

[00:09:51] Also vitamin A deficient as well a deficiency will down-regulate Mega

[00:09:55] Carl Lanore: [00:09:55] one as well, you know and people don't realize this but vitamin [00:10:00] A is also known as the retinoid X receptor modulator and the retinoid X receptor has been associated with hypertrophy of protein synthesis as well as stem cell differentiation.

[00:10:16] If you don't have enough vitamin real vitamin A Eliza just had her DNA done not too long ago. She does not convert carotenoids to vitamin A. There's a large percentage of the population that don't they really need real vitamin A sources, but if you're not producing if you're not getting enough real vitamin A in your diet, you won't build as much muscle as you potentially could absolutely.

[00:10:43] Ronnie Milo: [00:10:43] And then also too we spoke earlier about it is the down-regulation of Magdalene is is present when they're statins aboard because Megan is a LDL the lightbulb lightbulb density protein and that's responsible for the for the facilitation of that. But if you're on a Statin and you're limiting cholesterol mainly [00:11:00] ldls, then megwin is non-existent.

[00:11:02] Megan doesn't get into the transcription to bind to testosterone shbg. Then you start to see a lot of different effects like hypogonadism and different issues like that.

[00:11:13] Carl Lanore: [00:11:13] Well, that's so let's talk about for a second Megan is responsible for the biological effects of a variety of fat soluble and cholesterol soluble hormones and I'm lumping vitamin d and vitamin A into that because they are hormones, right?

[00:11:35] So. There's evidence that a reduction in Medellin could actually cause kidney damage and we all know that statins are well known to lead to kidney damage

[00:11:47] Ronnie Milo: [00:11:47] and liver damage as

[00:11:47] Carl Lanore: [00:11:47] well. And that's another one liver down. So when we're talking about Mega land because we're only interested in the effects of testosterone and DHT and also stuff, but the reality is that Megalodon is [00:12:00] unlocks the potential of a lot of.

[00:12:06] Cholesterol based and and fat based hormones, which have plea atrophic effects on the entire body the brain the kidneys the spleen. It's not just about you know testosterone here, right?

[00:12:20] Ronnie Milo: [00:12:20] And that's the thing too is love people understand that you're all your hormones are derived from from cholesterol, right?

[00:12:26] And then the regular medical agenda is to eliminate cholesterol because cholesterol will kill you but it's not the cholesterol that kills you is the oxidation of cholesterol. And what I really recommend is oxidation means when you put a banana on the counter turns brown that happens intercellular to their cholesterol, right?

[00:12:42] If you have an oxidation, it's could consume free radicals. It can bind to each other stick to the arterial walls cause cardiovascular disease hardening of the arteries. So the main thing is not to eliminate the cholesterol. It's eliminate the oxidation, you know, in high doses of Vitamin C. Does that antioxidant vitamin [00:13:00] E vitamin D is a very important role in that as well.

[00:13:03] There's a bunch of different things

[00:13:04] Carl Lanore: [00:13:04] glucose hyper oxidizes cholesterol, right as it does saturated fat. So when you have high blood sugar levels, you have hyper oxidation of both fats and cholesterol. This is why people go to the doctor the doctor says, why are you know, Your cholesterol is really getting up there.

[00:13:28] I don't want to have to put you on a cholesterol drug. So we're going to I want you to stop eating red meat stop eating animal fats, you know, just stay away from all that. So what is the guy eat or the gal eat instead of right? They eat a lot more carbohydrates a more pasta. They were bred because they they got to lower their cholesterol by eliminating animal fats.

[00:13:46] Well what people fail to realize. Is a triglyceride is three molecules of glycerol, and one fat and glycerol is an offshoot of glucose. So while they're [00:14:00] lowering their fat intake they're increasing their carbohydrate intake and what are they doing? They're raising. Their LDL cholesterol and they're hyper oxidizing it at the same time.

[00:14:12] This is a double whammy it's the easiest way to raise your cholesterol and damage your body at the same time doctors. Don't get it. They owe animal fat is the, you know, ancel Keys animal fat cholesterol. Stop eating eggs. No with those people should do is go to an ultra low carbohydrate diet stick to green vegetables eat more healthy meats and eggs and fish and their cholesterol will go down right

[00:14:40] Ronnie Milo: [00:14:40] also too high blood sugar will crystallize around flesh bone red blood cell count and make it very want to say sharp and incur sticking and all scraped arterial.

[00:14:50] Wall, right little Act. And that's where you see neuropathy is because in the capillary space it has to kind of Stack Up on each other to get through into the capillary space. But since they're so [00:15:00] jaded and sharpen nature that's not able to get into the capillary space because of the crowding of it then do start to see neuropathy and diabetic

[00:15:09] Carl Lanore: [00:15:09] and that is also part of the advanced glycation end product phenomenon when we talk about Advanced glycation end-products what we're talking about is.

[00:15:20] Things become crystallized with excess glucose kind of like rock candy right when you think about it and those AG he's are manufactured by your body when you have very very high blood sugar levels and okay. So a GES you can see them on the skin if you see somebody who has a ever-increasing number of liver spots and there's a name for liver spots.

[00:15:48] It's like flucos something. I'll look it up because Ron pain. I just taught me the name. We were taught we have this exact conversation. If you see those on your skin, you've got them on your organs to know if that's a fact [00:16:00] those are Advanced glycation end products and they once they accumulate they're very difficult to get rid of now.

[00:16:07] Why would you want to get rid of them? Well, let's look at the heart for a second. If you have one of those liver spots that happens to be on the the node of the heart where the heartbeat originates just like dropping a drop of solder on a PC board and bridging a bunch of runs you short stuff out those could be causing problems with kidney.

[00:16:31] Liver function heart function brain function there lesions we talked about lesions or oh, you've got lesions on your brain. They're lesions lesions are not good. But guess what potentially could reduce their accumulation. You're never going to believe it. You probably know

[00:16:48] Ronnie Milo: [00:16:48] elimination of Thunder.

[00:16:50] Carl Lanore: [00:16:50] Yo, yo, you'll stop it. You'll stop manufacturing them, but what can actually get them to recede? Low doses of [00:17:00] beta alanine.  low dose that you don't have to take the work out doses. You have take the one point four grams three times just take 800 milligrams of beta alanine a day, but do what you got to do it for years because it takes years for those things to accumulate they will start to actually go away beta alanine will reduce Advanced glycation end products that already exists in your body.

[00:17:26] No, no II take a little beta-alanine just for that reason because I I really am not looking for the buffering effect of it, but I'm absolutely interested in not accumulating more and getting rid of whatever I can when it comes to a GED because they are horrible. They're very very horrible, right?

[00:17:45] So let's talk a little bit about Mega land for a second and high cholesterol. So if statin drugs reduce. LR p 2 or Megalodon then it stands to reason to having [00:18:00] a fairly. I don't mean excessively High. I don't mean your blood is like sludge but you know higher than what we strive to have today.

[00:18:08] Probably increases Megalodon availability.

[00:18:11] Ronnie Milo: [00:18:11] Absolutely. Absolutely. It gives it more fuel to transcript it to make the mega lend to help with utilize here. I mean, so

[00:18:19] Carl Lanore: [00:18:19] are you familiar with the Hawaii studies the two studies done by the University of Hawaii about. Twelve years ago and left. So there are two studies done by the University of Hawaii on on Aging populations.

[00:18:32] Everybody in the population was 60 years old older. It was a longitudinal study.  They got two separate batches of data which produced two separate studies and the takeaway from the study was the people who had the highest cholesterol levels at the beginning of the study. These are all the people sick.

[00:18:53] Starting at 60 they check them every 10 years for 20 years. No one talks about these studies [00:19:00] especially doctors the people who had the highest cholesterol at the beginning of the study and maintain high cholesterol levels throughout the study was still alive at the end of the study. The people had the lowest cholesterol levels at the beginning of the study and or whose cholesterol level started to drop during this study will all dead by the end of the study, right?

[00:19:23] So it take away from the study was as you age maintaining higher cholesterol levels is actually protective.

[00:19:34] Ronnie Milo: [00:19:34] Absolutely. I agree with that a hundred sign

[00:19:36] Carl Lanore: [00:19:36] and megillah and maybe one of the reasons for all we know.

[00:19:39] Ronnie Milo: [00:19:39] Right. Like I said cholesterol won't kill you. It's the oxidation of the cholesterol that will so

[00:19:44] Carl Lanore: [00:19:44] yeah, I want to take our first commercial break when we come back.

[00:19:47] We're going to talk more, of course. I'm sure that they'll be running Megalodon tests at ReNew Life RX very shortly. Right if Ronnie has anything to do with it. And of course you can go to renew life are [00:20:00] x.com to get started reach out ask questions. They can help people all different states. They have a network of doctors all over the United States that they work with.

[00:20:09] I have so many people email me and say I just got an email a couple days ago. My doctor won't put me on testosterone. This guy is hypo gonadal. He's like in the low fours, but you know, they moved they moved the bottom of the assay down now to like to something so technically if you're a guy and you have testosterone in the 200s, that's the high end for women.

[00:20:36] So you're not a guy anymore. Right? And so I said, you know call ReNew Life RX man. They'll straighten out the run the test for you either get because his doctor said no you're okay. Because you're still within the range. Meanwhile, he's got horrible symptoms. He exhausted all the time. He's miserable.

[00:20:52] He's depressed.  He's probably

[00:20:54] Ronnie Milo: [00:20:54] young fella to

[00:20:55] Carl Lanore: [00:20:55] he is actually he's very young. He's only in his late 30s early 40s, I [00:21:00] believe.

[00:21:00] Ronnie Milo: [00:21:00] Yeah, so I'm definitely candidate

[00:21:02] Carl Lanore: [00:21:02] ReNew Life are x.com. Check it out. We'll be right back with more of Ronnie Milo stay tuned.  Wolf Anton is watching live and said this is a top shelf top shelf info it.

[00:21:15] Where can you get this kind of information just off the top of people's heads, you know, I mean, there's so many gurus out there today.  But again, superhuman radio will be years ahead of the curve for years to come as long as we continue to do the show and you know why that is because I'm not an expert.

[00:21:40] I am just looking to learn. The audience just comes along. I want to know about this stuff too. I mean, I want to I want to read this closing line from the article. It's really it's really interesting.  So.  one of the authors says.  that he [00:22:00] concludes that Megalodon plays a role in the cellular uptake of carrier bound sex steroids.

[00:22:06] That's that's. That is critical to proper development of steroid responsive tissue. This is the first time that not only has someone said that sex hormone-binding globulin bound sex hormones may actually be biologically active but shows that they not only are they in fact. But without Megalodon we have all of these problems as you pointed out, they actually gave rodents injections of testosterone, but these were rodents that are genetically predisposed not to produce Magdalene.

[00:22:46] The testosterone had no effect on them at all. So theoretically even the biologically active free testosterone didn't stimulate it testosterone response and tissue, which means that. Which means that [00:23:00] for decades we have been wrong, we've been wrong. Everybody looks at free testosterone and free testosterone probably means it's not active

[00:23:11] Ronnie Milo: [00:23:11] right?

[00:23:12] It's all about the activations all about to get intercellular to get the transcription process going to get the tissue to receive it for to be utilized, right. Also, you know going back to shbg is you still don't want it too high and you still don't want to little because it still has to bind with the testosterone a mega lend to get into intercellular.

[00:23:29] Right? And we always look at it shbg levels and I think shbg still important to a role, but obviously, you know, Mega one's more important, but I always always recommend or always kind of position shbg as. As the ninth batter in the lineup, right? He's a lot of sports analogies because I'm a coach.

[00:23:50] So the ninth batter people dismiss it all the time, right? It's a nice batter but I thought is very important rights to turn over the lineup you want to person that's going to be able to [00:24:00] draw walk or get get the person

[00:24:01] Carl Lanore: [00:24:01] overruns in right? Yeah,

[00:24:03] Ronnie Milo: [00:24:03] right. So or the punter in football, right everybody dismisses the punter but he score some points or the kicker score some points, you know, I mean, it could be a tight game.

[00:24:12] So we definitely want to look at shbg, right? We don't want it too low. We don't want it too high. We want to you know in a good optimal range so it could bind with the testosterone and then bind to the nebula, right?  I'm

[00:24:24] Carl Lanore: [00:24:24] just going to look at something. I'm looking at Megan production sun exposure.

[00:24:30] Everything always comes back to sun exposure. I'm telling you. I'm not. Hey vitamin, D production. Mechanism. Let's see the sun exposure now. I'll have to look this up real hard. This is going to take more than Megan an overview.  Yeah,

[00:24:47] yeah. Yeah, it looks like sun exposure through the ah, the Milano court and system may have a role in the production of megwin. Oh, yeah.

[00:25:00] [00:24:59] Ronnie Milo: [00:24:59] So peptide I don't an opt 141

[00:25:02] Carl Lanore: [00:25:02] they have the magic they have real melanotan to I mean, I haven't used it since the summer time, but I'm going to start using it again.

[00:25:08] I mean that's been shown to actually reverse arterial plaque accumulation. Think about that without going on a vegan diet or any of these other stupid ideas. The I have a blog post. I have to reshare it that Milano tend to given to write rodents that were genetically predisposed to develop atherosclerosis the body actually reabsorbed the plaque and that's because melanotan to shuts down inflammation as well.

[00:25:43] Right, so it's really magic. A lot of people think it's just about tanning. It's not about tanning at all. No, um, you know

[00:25:50] Ronnie Milo: [00:25:50] friends that too.

[00:25:51] Carl Lanore: [00:25:51] Hey, look at this. Dr. John Chrystal rest in peace said for years that chasing lower shbg was feudal. And in fact that what's more [00:26:00] important is the testosterone to shbg ratio.

[00:26:02] We're finding out isn't that true?

[00:26:05] Ronnie Milo: [00:26:05] Yes, absolutely.

[00:26:06] Carl Lanore: [00:26:06] So what is this? So what is The Sweet Spot to you got have you guys developed a an intelligent ratio assessment like we want you to be here and there.

[00:26:16] Ronnie Milo: [00:26:16] Yeah, so optimal levels or 2255 write anything under 20 is low and anything or 55 is high. So the optimal range that we know we consider is 20 to 25.

[00:26:26] Carl Lanore: [00:26:26] And is that measured in nanograms a dekaliter? Yeah,

[00:26:29] Ronnie Milo: [00:26:29] nanograms desolated. Okay. Yeah. Okay. Yeah in your same as testosterone,

[00:26:33] Carl Lanore: [00:26:33] so if you have a so, so theoretically if you have a 900 testosterone and a 50 shbg, that's roughly. Well, let me think about this. So that's 10 20. That's about a 20 to 1 ratio, right 20-20-20 testosterone to one shbg,

[00:26:57] Ronnie Milo: [00:26:57] right?

[00:26:58] So kind of [00:27:00] we we want to monitor that yeah. I'm not I'm not a mathematician so

[00:27:03] Carl Lanore: [00:27:03] I know I know I took me a second to think about that. Trust me. I was like I had to do it in time to do it in 10. Let's see 10 5500. Yeah, but God you want to monitor that you said?

[00:27:16] Ronnie Milo: [00:27:16] Well, I'm honored because we put John, you know HRT or G OT Artie Artie where we want to call it this week.

[00:27:21] We want to monitor because it could go up right it could go up and then we got to add a couple different things in to get it back down to Optimal range. And if it's low then we'll add some other therapies in there like HCG testosterone stuff like that, but we would want them honor. That's why we do blood work 3 6 and 12 months that modern these things because if it gets out of control.

[00:27:39] Now we're not seeing the success with the

[00:27:41] Carl Lanore: [00:27:41] program's interesting. So, theoretically if I'm on super physiological doses of testosterone, then I would want to observe the ratio more than the top end right

[00:27:53] Ronnie Milo: [00:27:53] and that's what we take account for. Right we take those two numbers together and kind of look at that and see what needs to be changed [00:28:00] and then also to symptom-based right, you know, somebody's on sooner milligrams of testosterone a week and they're not getting any relief and symptoms.

[00:28:07] We got to look at other things. Like I like I said BG gotta look at us dial estrogens DHEA all the other ones. It's not just one thing that helps its multiple things to help. It's a puzzle, right? We got to put the right pieces in the right. The great to end picture

[00:28:22] Carl Lanore: [00:28:22] so we know how we can raise Megalodon right just higher cholesterol levels and I'm not saying ridiculously high.

[00:28:29] I'm not saying go out there and destroy your your cardiovascular system because you want huh, but I mean higher on the normal end of high cholesterol levels of vitamin D production probably sunlight is best. But if you wanted to raise shbg, there seems to be a couple ways. Yeah,

[00:28:49] Ronnie Milo: [00:28:49] absolutely. Yeah, we use.

[00:28:51] I mean, you know, you'll see an increase as hbg if it's low with Androgen replacement right anytime testosterone,

[00:28:58] Carl Lanore: [00:28:58] but it's got to be it's got to be an aromatase [00:29:00] izing engine absolute because estradiol will raise shbg interestingly enough.

[00:29:07] Ronnie Milo: [00:29:07] Yeah, absolutely.

[00:29:08] Carl Lanore: [00:29:08] So if you take Master on that will actually lower shbg and that's because it doesn't Roma ties the.

[00:29:16] A lot of body builders would use Master on as opposed to using an AI because it lowers estrogen conversion to estradiol. But it also they'll use it to lower shbg as well. Right? I mean a lot of body builders do that. Yeah. Absolutely.

[00:29:31] Ronnie Milo: [00:29:31] Absolutely. But sometimes they'll use it without knowing what the shbg is to begin with right?

[00:29:36] So they're just shooting in the dark.

[00:29:39] Carl Lanore: [00:29:39] And then the other way that you can raise shbg and I'm not a big proponent. I'm not a proponent of daily metformin. I'm not a proponent of daily berberine and I'm not a proponent of daily Resveratrol because and dr. Mikhail blackish glowny who you're going to hear his first interview from 2010 next.

[00:29:58] Came on my show and [00:30:00] I remember what was that interview at the most recent one, but we talked about when we talk about rapid myosin, which rapamycin you take once every two weeks to once a week depending on how sickly you are and it has a it has a 36-hour effective life in the body. So you take it on a Monday.

[00:30:20] It's still working Tuesday and Wednesday. So keep this in mind for a second, but then you're off for two weeks. He came on my show and said it's a horrible idea to suppress mtor daily.  He and this is a guy who's done all the work on the role of mtor and ampk in anti-aging keep in mind that almost 30 years ago.

[00:30:44] He was talking about this in his colleagues and you'll hear it in the interview that I'm going to play said you can't use that in humans. Like that's it. That's a research chemical. You can't use that in humans and he said no we can. So.  He came on my [00:31:00] show and send it to terrible idea to suppress mtor on a day-to-day basis on a daily, you know, which is what daily metformin daily Resveratrol daily berberine do so, I'm not espousing that but if you do want to raise shbg, you can take Resveratrol.

[00:31:20] I would just take it maybe twice a week, you know, take a fairly nice dose twice a week and that's it but essay but but Resveratrol raises shbg interestingly, absolutely

[00:31:32] Ronnie Milo: [00:31:32] and there's a couple of things to try to identify to is. Why does somebody have low shbg, right. That's a lot of questions. Like what?

[00:31:39] How's your lifestyle? Right sometimes the sleep apnea contribute to low shbg because what's happening is they're not sleeping. And the body is not able to rejuvenate and circulate testosterone. So you'll see a low shbg right also insulin resistance

[00:31:55] Carl Lanore: [00:31:55] lowers

[00:31:56] Ronnie Milo: [00:31:56] shbg has diabetes. So there's a group maglia, [00:32:00] right and and and people that are you know,

[00:32:02] Carl Lanore: [00:32:02] giantism.

[00:32:03] Yeah, right?

[00:32:04] Ronnie Milo: [00:32:04] Yeah. Yeah. Yeah both. I roid another one that lowers sap, really? Yeah, yeah, so that's that's a one question. I asked when the blood work comes back and like why why do you have low shbg and I check I got after I questions. Like how does your lifestyle you know that we've done we look at other two factors, right?

[00:32:20] Is there blood glucose level elevated triglycerides elevated are the insulin resistance? What are they eating how the sleeping stuff like that because that contribute to Louis HPV.

[00:32:30] Carl Lanore: [00:32:30] So we have a question from Jeff Clint Clifton. Jeff Clifton says I have low testosterone but High DHEA s. Is there a correlation?

[00:32:38] What's your what's your the first thing I would say is what is your estradiol level? Because remember DHE DHEA is an aromatase thing Androgen. If a lot of its being siphoned off to estrogen it's not going to turn into te testosterone. What do you think

[00:32:52] Ronnie Milo: [00:32:52] right? I would I would also look at what's his luteinizing fshd.

[00:32:57] Right to contributing to the low testosterone right then [00:33:00] also lifestyle assessment. How is your stress? Right? Are you sleeping? Are you under a lot of stress? There's cortisol can lower the lower your test, but keep your DHEA levels as high as well. So there's a couple different questions a couple different modalities to look at.

[00:33:14] So to answer your question, as you know, we have to do blood work and look at other different factors to Carl's Point estrogen as well and see how you're performing. So I just can't make a determination. You know how one things working in one's not working.

[00:33:28] Carl Lanore: [00:33:28] Well, I remember reading a study probably almost twenty years ago that showed a correlation between High insulin and high DHEA.

[00:33:34] So that might be another thing you could have a high DHEA as a result of having high insulin level. So I would also say as estradiol levels should be checked. Luteinizing a follicle stimulating hormones as you point out should be checked, but all I would prolactin yes, but also.  Picograms of Miller 7.

[00:33:56] He's very very low estrogen that Devon [00:34:00] that's horribly low just for the ride. Oh if that's point seven or seven picograms a milliliter.

[00:34:07] Ronnie Milo: [00:34:07] Right

[00:34:07] Carl Lanore: [00:34:07] dangerously left. So so keep in mind that guys with excessively low estradiol tend to develop Parkinson's disease at like a tenfold higher rate. Estradiol is not something that should be crushed in Men In fact.

[00:34:24] In fact women catch up to us in the development of Parkinson's disease after they go through menopause and they stop producing high levels of estradiol and estradiol has been shown in studies. To protect the brain against a drug called mptp, which causes spontaneous parkinsonism in rodents. They took two groups of rodents.

[00:34:45] Actually three one got saline one got nothing and and and one got estradiol. They all were given mptp and only the group that was getting infused estradiol into the Carotid artery [00:35:00] directly into the brain. Resisted developing Parkinson's symptoms. You ready for this for six weeks all the other the other two Rats the controls and the ones that were just getting saline they develop symptoms in like that day.

[00:35:16] So estradiol protects the brain and men don't usually have enough of it. So you don't want your estradiol very very low 7.7. That's horrible. Wait a minute point seven picograms would be 70 nanogram. Yeah, now that's not so bad. That's not so bad. That's not 7900 grabs is a little high that's good.

[00:35:37] But I don't mean a little high like oh you got to work. Yeah, that that's actually good because most guys are in the 40s. So that's good. But yeah. I would absolutely also look at your blood sugar and you're either c-peptide or direct insulin production because insulin will raise DHEA, but it'll actually [00:36:00] suppress the production of testosterone

[00:36:02] Ronnie Milo: [00:36:02] right and and to your point about estrogen or estrogen dial.

[00:36:06] So starting to feel a lot of these clinics in fuse or. Compound and that wall inside the testosterone right? And to me that's that's really a bad thing because you can't control that right there getting one milligram of an ashes all compound and then and to 200 milligrams of sipping a you can't control that and what we do is we look at the total numbers.

[00:36:31] And then we'll recommend, you know in ashes all but we'll hold off of it. And so you start to get side effects. If you start to get side effects you call me or email me or text me and be like, hey, I'm starting to see some side effects of aromatization. Then we'll add them back in slowly and then we'll do another Blood valuation 3 months to see where it's at.

[00:36:46] Right because estrogen is very responsible for sexual health brain function like you said joint function bunch of different factors, and if you crash your estrogen you will feel like. Like a 90 year old woman

[00:36:58] Carl Lanore: [00:36:58] who remember when a [00:37:00] TD was all the rage back in the day when we're all in the forum's the bodybuilding forums.

[00:37:04] Oh, yeah, so guys so you took it. So then you could I never took it but so you could speak to this. So back in the day a TD was an aromatase inhibitor and it crushed it made and astra's all look like I don't know like like an amateur. Yeah. It's a suicide inhibitor has a high Affinity to estradiol and it stays around in the bloodstream for long period of time guys would take a TD and by their third day their libidos would crash they couldn't even get erections you remember that.

[00:37:36] Ronnie Milo: [00:37:36] Did that to you can't get out of bed in the morning, you have hot flashes and then the bottom of your feet feel like you're walking on glass. Yeah, it's weird like think you walk on glass and you're like, there's got to be glass in my feet, but they're not because it's so dry. It dries your joints out to that.

[00:37:51] It feels like you're walking on glass and people call me all the time. Like how do you know about that symptom? Like I've had it before and I let's look at your estradiol and [00:38:00] it's seven. I'm like, okay, let's stop in after. All right, stop it all together right now. And then with incomplete they call me back man.

[00:38:06] I feel so much better. You know, I'm more motivation. You know, I want to have sex with my partner. You know, I'm like, okay good. Well, we got that under

[00:38:12] Carl Lanore: [00:38:12] control. I want to go ahead and answer Stephen Hollins Bennett's question. And then we're going to take a less commercial break. So he says why no daily berberine or Japanese knotweed Resveratrol.

[00:38:25] So first first I have to preface it by saying this.  If you are not insulin. And you don't have excessively high blood sugar levels. Maybe you're a fan of intermittent fasting or you have a low carbohydrate lifestyle or your keto you should not be taking.  berberine Resveratrol or for that matter metformin.

[00:38:50] If you are sick and I use that word specifically because if you have very high insulin levels, if you have very high glucose levels, I mean, they're in the high 80s into the [00:39:00] 90s you're creeping up into the hundreds pretty soon. You're sick, then you can take those as a rescue mechanism to minimize the damage to your body from.

[00:39:13] The excessively high blood sugar levels and we've talked about one of them already advanced glycation end-products. Ronnie talked about neuropathies the okay, but if you're not sick, if you're a healthy person and you're using those and you are shutting off mtor around the clock the mammalian Target of rapamycin is thought to be this parlor trick that increases muscle mass and protein synthesis, and it does do those things.

[00:39:41] But mtor also has profound effects on the immune system mtor also has profound effects on bone mineral uptake in bone density Emptor has profound effect on brain function. So this idea that I'm a healthy guy and I'm going to just start taking berberine every single day because [00:40:00] some guy wrote an article about how great it is.

[00:40:03] It's a it's a really a bad idea. So pressing M tour around the clock is not a good idea. But turning em tore off the periods of the day like fasting and turning ampk on that's a good thing. That's the way your body was designed to work. It wasn't designed to be this way only or this way only and the one other thing I want to mention.

[00:40:27] So much that we think we're being told today is healthy and anti-aging. Is juxtaposed the backdrop of a very very sick population and I'm going to give you an easy example, you're going to think to yourself, but wait call. I thought you said fuk. I thought I was told fiber is good. So if we look at things from an evolutionary perspective wood fiber have been good for our ancestors fifty sixty seventy thousand years ago a half a million years ago.

[00:40:55] Let's think about what fiber does it slows gastric emptying so you eat in your [00:41:00] phone. And your blood sugar doesn't rise too fast because the food in your stomach is moving slowly motility shuts down food moves slowly, but you need to gather and eat 5,000 calories today, but right after a high-fiber thousand calorie meal you don't feel like you could eat for five hours.

[00:41:20] Would that have served us? Well from an evolutionary standpoint know we would have died. Yep, right. We wanted highly dense food that we digested easily that went through US easily and made room for more food because now we're going to walk to another area and find something else to eat. So who does high fiber dive diets benefit those who suffer from a disease has of modernity today who they're so sick already that the only way that we can control their blood sugar is too slow down the emptying of their.

[00:41:52] Digestive motility is a gift being able to digest food quickly and efficiently and get it out of you is a gift [00:42:00] but if you're a sick person then fiber is important to you because you have to artificially slow that process down, right? So a lot of things today that we're being told are good for anti-aging.

[00:42:11] Yeah, they're good for anti-aging for people who already aging really crapola. They're like really really sick and they're like, you know, they're going to be in wheelchairs by the time they're 70, they'll probably live to 90 but in an institution, yeah that's anti-aging for them for those of us who intimate and fast.

[00:42:28] We keep our blood sugar levels down. We monitor this stuff. We don't need fiber. We want the food to be digested and go through so we can have more food in two or three hours. Guys are ready

[00:42:40] Ronnie Milo: [00:42:40] to rescue tools. If you're sick, then that's what you need. But if you're a healthy individual healthy lifestyle, like you said intermittent fasting or any kind of diet that you're doing and you train you don't need these things.

[00:42:52] Carl Lanore: [00:42:52] No. No, you don't think you don't bodybuilders who use a lot of fiber. They have a hard time consuming all the food that they need to eat and [00:43:00] then and then and then fiber is just mass building. So here's another misunderstanding. People will shift to the carnivore diet. They'll eat nothing but chicken breast and salmon and meat eggs and and and turkey and and they go.

[00:43:14] Oh, I'm constipated. Why are you constipated? I haven't pooped for two days. No, you're not constipated. You're on what's known as a low residue diet. A low residue diet means that 90% of what you're eating is actually being metabolized and used by your body and the waste product made from it is very very little so after you poop that third day you'll start pooping every day again, but smaller amount now a high residue diet is 40 grams of fiber a day people think oh, I got to get 40 grams of fiber today and they poop like Carvel they got to go to the bathroom three or four times a day and.

[00:43:54] And it's disgusting and it takes them a half-hour to wipe and clean up. That's not that's not good. [00:44:00] That's not a good thing. No.  We've got it all confused because we're using sick people to dictate. What is considered healthy today. That's right. And on that note. We're going to take a break stay tuned right back.

[00:44:14] Welcome back you like my hat.  I do it says hunt with a Henry.

[00:44:20] Ronnie Milo: [00:44:20] Yeah,

[00:44:21] Carl Lanore: [00:44:21] you know, you know Henry rifle is. So we're going to have a banner ad very shortly up on superhuman radio to get an amazingly beautiful like like coffee table quality catalog for Henry Rifles. Nice when I was a kid. I always wanted a Henry 4570 and I got myself one this year for my 61st birthday took a little while.

[00:44:46] But you know, it's not a terribly expensive rifle either. It's not like some of these other minute I think it was. Six or seven hundred dollars, which a lot of people may think is expensive but not when you see this rifle Henry [00:45:00] Tyler Henry.  Invented the repeating rifle the lever action repeating rifle prior to that.

[00:45:09] We had trapdoor rifles and rolling Block rifles that you basically cocked and you pull the shell the spent shell out you put the new one in and you close it and you shot. So basically they all single. He was the first guy who made a rifle with a feeding tube on it and a spring in it that basically pushed the next Shell back.

[00:45:29] So you when you cock the dejected one and pull the next one up that revolutionized the West that revolutionized the army that revolutionize everything because prior to that everything was pretty much single shot, right but Winchester is erroneously attributed. With this because everybody thinks when you have a lever action rifle, it's a Winchester because Winchester came out and copied his design.

[00:45:55] And they basically came out with the lever action rifle. So so [00:46:00] so Henry Rifles is probably one of the oldest. Firearms manufacturers in America today, they're still made here in the United States and they're owned by an Italian guy who's originally from Brooklyn. So, you know, I got to love them, right?

[00:46:14] Ronnie Milo: [00:46:14] Yeah. I love

[00:46:14] Carl Lanore: [00:46:14] already Anthony Anthony imperato and I love Henry Rifles because it's about the history and the heritage of the Henry rifle and everything that they do. Is like they have the best actions leave her actions in the world. Marlin makes a nice one, but it's nothing compared to the Henry.

[00:46:37] So I'm convinced that my audience would appreciate knowing about Henry rifle. So I'm actually going to put a banner ad up on my website that you can click and absolutely for free get a copy of the Henry Rifle catalog. Sent to you II got to tell you I'm warning you. Now, if you're a gun enthusiast this catalog is going to make you want to [00:47:00] Henry because they are when you look at them you like.

[00:47:02] Oh my God, I remember seeing that rifle in pictures of the Civil War or the Buffalo Hunters. Yeah. That's it. These are the rifles that literally. Made the wild west step into line and so I'm proud to have one and I'm going to hunt this year with my Henry and everything. So there you go

[00:47:20] Ronnie Milo: [00:47:20] it Chuck Connors from The Rifleman use that one.

[00:47:22] Carl Lanore: [00:47:22] So he used a rifle that Henry makes and it's actually called a Mare's Leg because it looks like a little horses leg. It's a shorter version and it's got the big loop. Yeah, the thing that you know, you can you can swing it and cock it and all that says yes. Yes now, I don't know that they use the Henry rifle in the TV show with Chuck Connors, which was called The Rifleman.

[00:47:47] I don't know that that was a Henry but yes, they they still make that. That weapon they still call the mayor's leg and it has a saddle ring so you can put it in your saddle and tie it so it won't come out while your horses [00:48:00] galloping their everything everything. They make is authentic to the way it was back in the day, except, you know, they take advantage of better calibers now better technology.

[00:48:08] But yeah, they have it. It's called the mayor's leg Yeah

[00:48:11] Ronnie Milo: [00:48:11] Yeah, my father used to make me watch that when I was a kid

[00:48:14] Carl Lanore: [00:48:14] and Marshall remember the kid mark. Yeah, son Mark. Yeah. Well, I used to love nobody. I used to watch that when I come home from school. The right-hand man

[00:48:23] Ronnie Milo: [00:48:23] Chuck my dad so much is that you watch it on the wood that the old-time

[00:48:26] Carl Lanore: [00:48:26] Network?

[00:48:27] So his first I can't think of his first name. It was McCain Lucas McCain Lucas McCain. Yeah, The Rifleman and whenever and whatever he got in trouble somebody referred to him as a Sod-Buster. Which I guess is somebody who like digs group breaks the ground, you know, like a farmer is probably a Sod-Buster.

[00:48:47] Yeah, he would take that right flat. He would spin it once and Pop-Pop. And so yeah to to make that happen on the lever action. You have to put a little a little [00:49:00] tab of metal that you flip up. So that every time you cock it as you close the chamber that tab of metal hits the trigger and fire is it and basically turns it into a semi-automatic.

[00:49:10] Yeah, it's pretty cool. Yeah, I wouldn't want to do that with my 4570 cuz it just kicks way too hard. Oh, yeah, but back then they had 44 s those were 44 is most often 44 caliber 4045 special in those rifles, so they didn't kick nearly as hard as some of these bigger caliber. But anyway, okay, I digress.

[00:49:31] So there you go hunt with the Henry there you guys I got a new hat. What else do we need to cover everything else? I

[00:49:36] Ronnie Milo: [00:49:36] mean that's about it. I mean if they want to contact me, you know, they can hit me at my email address. My low am ILO at ReNew Life are x.com or you go to a website ReNew Life RX.com and then fill out a schedule call and then myself or animal will give a call back.

[00:49:54] Carl Lanore: [00:49:54] Excellent. And Adam is in La this week. I hear he's he's getting ready to become a movie star.

[00:50:00] [00:49:59] Ronnie Milo: [00:49:59] Yeah. Yeah, he's still out there this week you met with a bunch of clients out there had a bunch of business meeting couple podcasting recorded. So he's doing big things.

[00:50:07] Carl Lanore: [00:50:07] Yeah, he pot. He recorded a podcast for Entrepreneur magazine their website entrepreneur.com.

[00:50:13] Ronnie Milo: [00:50:13] Yeah. Yeah, he's going to be doing a lot of podcasts like in the next couple months.

[00:50:17] Carl Lanore: [00:50:17] Oh just to get the word out in other words.

[00:50:20] Ronnie Milo: [00:50:20] Yeah, yeah, just to get the word out but it more of a you know for his entrepreneurship and book. So

[00:50:26] Carl Lanore: [00:50:26] yeah, very good. Excellent. Great guy. He deserves great success as do you Ronnie?

[00:50:31] Thanks for being here today, brother. Thank you, man. And then I'll see everybody. So don't forget to tune in to these shows next week. I promise you they will reawaken things that you forgot and get you back in line. They're all fantastic chosen those of you who have not. I've been listening to supremum radio for the past ten plus years.

[00:50:50] We are 14 years old this November. Yeah, we are the oldest longest-running Health Fitness and anti-aging podcast in the world in the [00:51:00] world. Think about that. So check

[00:51:02] Ronnie Milo: [00:51:02] it when you land some old

[00:51:04] Carl Lanore: [00:51:04] off topic. I actually found all of them the other day you have every single one of we on that hard drive.

[00:51:09] I had to go back. You know, I have all these removable hard drives and then the original shows are on CD that I had a put on the hard drives and I was like, oh my God, here's all the off-topic shows every single one of them.

[00:51:23] Ronnie Milo: [00:51:23] Those are those are girls are good shows. I remember listening back in the day.

[00:51:26] That's when I became a fan.

[00:51:27] Carl Lanore: [00:51:27] Yeah, I got to be careful about that. That's a side of me that I don't know that I want people to know about ha ha ha anybody go there you go. Keep the secret for me. I Ronnie thanks for being here brother. I will see everybody next week. I got it. I'll be off tomorrow and Friday and all of next week returning the following week.

[00:51:45] So there you go. Ride

[00:51:47] Ronnie Milo: [00:51:47] safe travels man. Have fun.

[00:51:48] Carl Lanore: [00:51:48] Take care see everybody later. Thanks for

[00:52:11] [00:52:00] listening.