[00:00:00] Carl Lanore: [00:00:00] Welcome back to another episode of super human radio. Today is March 25th, 2020 for those of you listening to this show a hundred years from now and realize we really knew what we were doing here in this audience. Want to thank my title sponsor legendary foods, the remarkable tasty pastry, which is basically a pop tart with nine grams of protein, less than one gram of sugar.

[00:00:25] So healthy, give them to your kids. They won't know they're healthy, a great dessert. And of course, they're amazing nut butters, which are too vast to name all of them. Uh, but I can tell you that every one of them is delicious. I eat them out of the jar. Uh, again, zero sugar in their nut butters. Uh, go to eat legendary.com.

[00:00:45] Show them some love. Uh, they make this show possible. So. We've been talking about genetics and epigenetics now for pretty much the entire time I've been doing this show in one way or another, and we know [00:01:00] that you are not a hostage of your genetics. In fact, many of the twin studies that we've talked about on this show over the years have shown that.

[00:01:10] Two twins come out of the same womb, uh, grow up in the same household and then go off in different directions in life. And you know, one developed breast cancer, the other doesn't. They both have the Brocket gene. So this has been a big eyeopener because for a long time we thought genetics was everything.

[00:01:28] It was basically you live or die by your genetics. The analogy I like to use about genetics is like this. You know, I spent a lot of time with race horses. Your genes are like a race horse. They have potential. They may have some problems, you know, sore shins. The jockey you put on the racehorse determines whether or not that race horse is going to win a race or break down during a race.

[00:01:56] Epigenetics is like that jockey. And [00:02:00] the things that you encounter in your life, those determine your outcome way, way more so than your genetics. We have two fantastic guests on the show today. Yeah. Uh, we have, of course, returning the Dr. Williams seeds. How are you doing dr seeds?

[00:02:18] Dr. William Seeds, MD: [00:02:18] Doing great, Carl. Good.

[00:02:19] Good.

[00:02:19] Carl Lanore: [00:02:19] And then we are joined by Dr. Daniel Elias. Martine, herons. Did I pronounce that right? Yeah,

[00:02:27] Dr. Daniel Elías Martín Herranz PhD: [00:02:27] that's fantastic. Help.

[00:02:28] Carl Lanore: [00:02:28] Okay. But I'm just going to call you Danny to make it easier for me. That's

[00:02:32] Dr. Daniel Elías Martín Herranz PhD: [00:02:32] all good. That's all good.

[00:02:33] Carl Lanore: [00:02:33] All the way from the K and, and ultimately what you're going to learn today is why it's important to pay attention to epigenetics and now you actually can, and this audience is going to get an offer that has never been available in this world ever before.

[00:02:53] So just keep that in mind. So, dr seeds, since you kind of hooked all this up, um, [00:03:00] bring us along with this. What, why, why is it even important that we pay attention to our epigenetics?

[00:03:08] Dr. William Seeds, MD: [00:03:08] Well, call this, this is a great question and a great lead into, I think, what is going to be the way in the future that we look at health and we look at how the environment.

[00:03:22] And the world affects our health. And this has been something, you know, I, I, uh, lead the international peptide society. We're involved in significant research and the use of peptides. And we've done, I think, tremendous things in, in changing how we're able to improve cell efficiency. And. Change the scope of how we look at cardiac disease, diabetes, immune disease, and cancer.

[00:03:52] And we've made significant strides with this, just like we do with exercise, just like we do with nutrition. [00:04:00] You know, the two top players that you can actually see changes in the body. You can look at body composition, you can look at things like body logic and look at muscle mass and. Bone density and all of those things that can change, and those are things we can look at.

[00:04:17] Lab testing is a little different and individual, and it, it, it's, it's controversial as far as, you know, what real improvements are we making in somebody's life? And I've been fascinated with the genetic code and understanding. The potentials of if we could really harness what the genetic code is supposed to do and if we could monitor it and follow it, that would be the ultimate way to look at how all of these things affect the body and the cell efficiency basically.

[00:04:58] So. So this [00:05:00] is this kind of, let me, let us down the pathway of this, of looking at epigenetics, which is basically, it is the environmental forces, the, the, uh, metabolic forces, nutrition, exercise, all of these things together and how they play a role in commanding what your genetic code will produce. And this is.

[00:05:27] What, what really the focus of the, the next steps that we've seen over the last few years, we've seen this big push with what's called the biological clock, and we've seen presentations and papers now that where epigenetics can actually tell us now with great accuracy what. Potentially can be our biological age.

[00:05:56] So when we started seeing that, and, and looking at this [00:06:00] from a, the, the, uh, peptide side of it, we're like, Oh my gosh, this is something we really need to focus on, to, to really push forward all our research in moving down this pathway of using the epigenome to validate all the things that we're doing.

[00:06:17] And. So that led me down this quest of looking for, okay, well, what's out there right now and what's important? Well, important aspects of looking at the epigenome. We want accuracy, we want reproducibility, we want, we want everything to represent what we're doing. And, and lo and behold, in the world, that led me, that led me right to a growing Omix.

[00:06:44] And I think, uh. I think it speaks for itself is this, Danny will will express, and I, I've just been very fortunate to meet some very brilliant people that were, we're all in the same line of thinking and it's there on the [00:07:00] science side. These guys were brilliant and I'm going to let Danny take that forward, but they are on top of the game where they've given us the ability now to make those steps and I can't tell you how excited I am and how we are excited here.

[00:07:16] To look at everything across the board in how we can start changing lives. And, and I just want to bring this point up real quick so I don't forget it. When I first met Danny and we started talking about all of this science and stuff, we hit it off really well. And, uh, I, I, and, and I'll never forget this recently, what Danny told me, dr seeds, we look at this as.

[00:07:42] You are creating your digital twin and your digital twin is going to always be there for you to follow. And I'm like, Oh my God, that makes so much

[00:07:54] Carl Lanore: [00:07:54] sass. Let's see what the, especially with my introduction with the twin model where you know, you have this twin [00:08:00] who doesn't suffer diseases and you have this twin that does, and now you can look to that twin and say, what did that twin do differently?

[00:08:07] What can I change about what I'm doing? That's actually brilliant. That's a brilliant, uh, perspective. Uh, Danny, tell me about yourself a little bit. First of all, you studied at Cambridge, you actually did your thesis on epigenetics. Did you not?

[00:08:22] Dr. Daniel Elías Martín Herranz PhD: [00:08:22] Yeah, that's right. Uh, thanks so much guys for the intro. That's, that's a really great information, I really good way to, so we could start this discussion.

[00:08:30] So I'm really excited to you to be here today. Uh, just be with you guys. Um, so yeah, maybe it's useful to give a bit bit of a background where, where I come from and then also maybe where Cornell mix come from. Um, so my journey actually a scientific journey started back in Spain. Uh, so I did an undergrad in biotechnology.

[00:08:48] Um, back then is when I got really interested in all this new technologies that were appearing to, to measure DNA. You know, very high throughput, minor, right on this, stoke their seats booted. Um, you know, we live in [00:09:00] credible times in terms of what kind of I'll be done with, with this type of data. And you know, how accessible is becoming very, very fast.

[00:09:07] Right? So I got fascinated by that and then I decided to go to Cambridge university here in the UK, uh, to do my masters. Uh, basically focus on, uh, you know, analyzing large amounts of, of this type of data. Uh, I'm black. Then I was a steel, you know, pretty much coming from that genetic field, actually. So, you know, I was interested in, in the genetics of cancer, uh, and this sort of things.

[00:09:31] Uh, but, you know, and that was at the time where, uh, genetic tests were really starting to, to flourish and, you know, become trendy. Um, people were starting to realize that this could be used by consumers. Um, and, you know, I, I got also captivated by that. But the problem that I saw with that was that. You know, we were missing a great part of the story, which is, you know, all this lifestyle, environmental factors that, as you guys mentioned before, how far profound effect in, in the [00:10:00] risk of developing a noncommunicable diseases.

[00:10:03] So that's why, you know, uh, I decided to, to get involved with, with a type of data on a framework that allowed me to, to also quantify those sorts of things. And that led me. Obviously two to epigenetics, and I decided to start my, my PhD, uh, at the European bioinformatics Institute, uh, which is one of the hubs of biological data in the world.

[00:10:25] Uh, on there, I was lucky enough to you to be working with professor Dame, Janet Thorton, uh, who's an expert in this field, and also in connection with, with agents. So, you know, I got connected both, uh, to the, you know, computational, big data side of things. Uh, the epigenetic side of things through professor who world fried as well.

[00:10:44] Um, and then, uh, finally to, to, you know, the biology of agents. So that was. You know, uh, at the time where the main thing that was being discussed about this was, uh, there'd be Trinity clock, uh, so horrible hot publish sheets, you [00:11:00] know, landmark paper. Uh, you know, it was a very, very hot topic. Um, and you know, I got captivated by this because, uh, you know, for me, the fact that we could measure agents.

[00:11:12] So I currently on finally being able to quantify all this lifestyle environmental factors, uh, you know, that really had a big impact in, in the way that I was thinking about, about this problem as well. So then I decided to go and spend four years of my life trying to understand, you know, what the hell is going on in our cell?

[00:11:30] Some tissues for there, for the horror of us below to be so accurate. Um, so yeah, since any my PhD was, was around what's around that, trying to understand the mechanisms of the epigenetic clock in humans. Uh, I knew it was, it was back then when, when I met, uh, also, uh, Konami's co founder and CEO, Dr. Thomas stops.

[00:11:51] Um, so he was working on kind of the same problem, but from a different angle. Um, so he was looking at the mouse, uh, [00:12:00] and developing essentially what it is, the first, uh, multi tissue, uh, biomarker for aging, uh, in the mouse, which is the equivalent to, to the Horvath, uh, epigenetic clock, uh, five for a model organism.

[00:12:14] And this was obviously, you know, also very exciting because for the first time we could, we could measure this in model organisms and, you know, start to. As the question of, you know, if we, if we give this a specific drug to the mouse, or if we, uh, you know, change a bit, this is specific genes, can we affect the aging process?

[00:12:31] And hopefully one day, you know, I play this to humans, so obviously we got along very well both scientifically, and I'm personally. And you know, that let us do, to try to bring this, this type of data, genetic data, uh, you know, to, to the world, uh, to your free, to their people, uh, in the context of preventative healthcare.

[00:12:52] I know. So as I'm sure we will discuss a bit later, uh, go beyond, you know, biological age and also try to measure all the main risk [00:13:00] factors for, for noncommunicable diseases.

[00:13:02] Carl Lanore: [00:13:02] So that's a great segue into this question. So. The reality is the real magic and understanding and measuring epigenetics isn't just being able to say, Oh, I'm, I'm 60 I'm going to be 62 this year.

[00:13:18] Oh, you're, you're, you're going to be 62 but you have the body of a 45 year old. The real magic is that epigenetics influences our DNA so that we can, once we, so, so knowing that number is no big deal. To me, knowing how to alter that number. Is the big deal. So with, with chronometer, you can also assess what I'm doing in my life that's influencing the genetic outcome so that I can reverse the clock.

[00:13:50] Is that, is that a fair assessment?

[00:13:54] Dr. Daniel Elías Martín Herranz PhD: [00:13:54] Yeah, that's right. So obviously, you know, we've been trying to soul aging. [00:14:00] Uh, since you know, he money T aware of death. Um, and the main problem that we had with this was that we didn't have an accurate way to quantify agent because agent is a very broad term, right? So we're all familiar with the fact that we have a higher risk of, of Dianne, um, over time as time passes by and also of developing, uh, Benny diseases.

[00:14:22] Um, by, you know, until very recently, we didn't really. Understand, first of all, what's going on in our tissues. Uh, and secondly, how to measure this. And if you want to change something first, you need to be able to measure it. Um, so if you want to develop, you know, a drug to slow down an aging person, you know, you need to be able to tell whether something is working or not.

[00:14:45] Right? And that's why, you know, with the appearance of this new biomarkers of, of the aging process in humans, this has been a massive revolution. Um, I now for the first time, we're gonna start to ask the question of, is this drug slowing down aging in [00:15:00] humans? Is this diet slowing down? Aging in humans is this type of exercise and slowing down aging in humans.

[00:15:05] And you know, just thinking about that, it's, it's really incredibly exciting.

[00:15:09] Carl Lanore: [00:15:09] This is so exciting, dr seeds. But you know what? I'm thinking, this is going to piss a lot of people off, have been doing things and thinking that it's working for them or selling products or selling ideas that they think is going to hold back aging and they've been wrong all along.

[00:15:25] Dr. William Seeds, MD: [00:15:25] Well, you know it at least a, at least we're all, we've all been trying, but yes, I mean, this is what science is. This is the juice, is the beauty of science and, and week. Now, I mean, I, this is why anytime I get to talk to Danny and Tom and the group, I mean, this is, I can't tell you how exciting it is now that we are looking, I mean, we could talk all week.

[00:15:49] I'm sure we'll have many shows to keep going here, but. We've already got projects in line and are already proceeding with how we're going to look at everything. I mean, we're going to lead, [00:16:00] we're going to lead the world in this. We're going to lead the world and showing how we change the epigenome.

[00:16:06] Because the beauty of this is you can not change the genetic code. You can't change what your genes are, but you sure as heck can change the epigenome and that's what we're going to do. And I'm, I could just keep going.

[00:16:21] Carl Lanore: [00:16:21] Yeah. Excited. I am too. I got to tell you the truth. You know, um, I don't think I'm aging as well as I think I am.

[00:16:28] Just for the record. Um, I have some, uh, what I can only call autoimmune issues that my father had that my sister had that my aunt Kay had. So clearly there are certain things in my environment. There are certain. Foods I eat. You know, I always say this to people, you know, people go, Oh, well, you know, you get your genetics from your parents, but you also get a lot of other things from your parents, like the fact that you like pasta or something like that.

[00:16:52] So it's not, it's not just about your genetics. I'm very excited about this as well. Um, Danny, [00:17:00] how invasive is this? Like, so if I wanted to undergo this process with the quinoa mix, and we have a special offer, I'm going to just tease everybody, stick around. Because a never before and I, this is not sales puffery, 70% off.

[00:17:16] This used to be only available to executives and wealthy people, 70% off. We are going to put this in the reach of anybody who wants to do it, but just the first 500 people, because literally this is a, this is not even a break even even deal, but stick around. So what do I do? Do I have to, and what kind of tests?

[00:17:35] What do I do? Blood, blood work. How does this all work?

[00:17:39] Dr. Daniel Elías Martín Herranz PhD: [00:17:39] Yup. So one of the things that we wanted to do from the beginning of  was to make this very accessible to everyone on really, you know, uh, democratize and, you know, make it very accessible, uh, to people to, to take this type of tests. And, uh, you know, the way to do this obviously is.

[00:17:55] You know, one thing is, is the cost, but the other thing is about how you [00:18:00] collect, uh, you know, that, that data, right? I'm, you know, from the very beginning, we made the system that we wanted to do this from saliva, which is, you know, a tissue that is very easy to, to access, very easy to collect. Very easy to transport and, you know, all you really need to do is to take, you know, basically our tube guide that we will deliver to you.

[00:18:19] And then, yes, spit on it for, you know, a couple of, couple of minutes for a minutes. And then that's, that's about it. So, you know, the good thing is dieting. Now we're saliva. We have, uh, you know, a lot of cells that come from our immune system. Um, so, you know, when people talk about saliva, they don't really know that there are a lot of cells that are actually similar to the ones that you find.

[00:18:40] Uh, in blood. Uh, so this allows us, so part of the IEP that we have to develop on the RMV that that has happened at porno mix as being, to actually make this biomarkers, uh, among the biological age, very accurate to work from an Oni basic tissues. That's his, such a saliva. So people can, you know, [00:19:00] easily sample themselves and, you know, do this without, without any, any pain or effort.

[00:19:06] Now

[00:19:06] Carl Lanore: [00:19:06] this had to be reversed engineered. I'm just thinking about it. Right? So you had to have large populations of data, data from large populations to make your assumptions and then overlay them on the data and go, yeah, we will write about that. Is that how this all evolved? Uh, Danny.

[00:19:22] Dr. Daniel Elías Martín Herranz PhD: [00:19:22] Yeah, that's, that's part of what happened, obviously.

[00:19:25] Um, so we have validated, uh, you know, that our, our biomarkers work, uh, in large populations, uh, and we have poster validated that they, you know, they work very accurately in saliva. And that's, you know, that's really exciting with think because I brings this technology, you know, to, to a type of test that is very, very easy to use, uh, by two people.

[00:19:47] Carl Lanore: [00:19:47] One list. Of course, dr food's good going.

[00:19:50] Dr. William Seeds, MD: [00:19:50] Sorry. I think what really needs what, what I could add to this, Danny, if you don't mind, is I think what's real important to understand what this technology and [00:20:00] how they've brought this forward is this is next generation genome sequencing. They're doing something different than what is being done out there right now and what's called a re sequencing, um, for the most part.

[00:20:13] And they're doing it. With great accuracy because they're looking at, so with genome sequencing, next generation genome sequencing, you can look at every base pair in the genetic code. You can look at 3 billion pairs. The technology is there now. It's just the expense of looking at all that. Well, they've taken it to the next step where most people out there now are looking at.

[00:20:37] You know, 100,000 sites are markers, maybe up to 400,000 if they can. These guys are looking at 20 million different markers. That's enough said right

[00:20:53] Carl Lanore: [00:20:53] there. Who developed this process? Danny.

[00:20:58] Dr. Daniel Elías Martín Herranz PhD: [00:20:58] Yeah, I'm so obviously, you [00:21:00] know, I for no makes, we are very excited to, to bring the latest technology as well. Uh, so from the very beginning and the same way that we committed, uh, to, to bring it in a noninvasive way using saliva, we also committed to use the latest technology available.

[00:21:14] Right. Um, when we started with this, is this. This was a bit risky, right? Because obviously everyone else was using that different thing. But you know, we wanted to move the field forward. We wanted to start to collect the  genomes with that quality and quantity that was unprecedented before I population scale.

[00:21:30] Uh, and that's, you know, that's really what's, what's behind the . So dr sits correctly, Manson, what we use is next generation sequencing. So there are two main types of technologies to measure the DNA. One of them would be next generation sequencing and the other would be a race based technology. So I raised space technologies.

[00:21:48] Uh, they were used, you know, by, by the, at the beginning when people were doing genetic testing. I know. So they are used by other. Uh, you know, be genetic testing companies, but we decided to move to next [00:22:00] generation sequencing for different reasons. First of the full, you know, dialysis to quantify many more sites, uh, in the epi genome.

[00:22:06] So at the moment, we quantify 20 million. Uh, persistence in the DNA. That's a lot of information. Wow. That's a lot of G gas off information to, to be processed. And, you know, it gives you a really, really good view of the human epi genome. Uh, and we look at, you know, parts of the epi genome that no one else has seen before.

[00:22:24] And that's, you know, that obviously powers a lot of discoveries that otherwise. You know, would not be possible with, with previous technologies. Uh, obviously there are also technical considerations about, you know, how I create on, you know, the potential, uh, box effects that are derived from, from my Ray based technologies.

[00:22:42] Uh, but without going too much into, you know, details seem to that, uh, basically we, we had work in the past, uh, when we were researching on, on array, and we decided to kind of step up and I'm bringing next generation sequencing to epigenetics genetics. As the platform  technology of choice. [00:23:00] Um, and obviously what this means is that this also lowers a lot the cost, uh, when you consider how expensive it is to measure, it's one of these positions, right?

[00:23:10] So we, if you actually conceived there, that the amount of data we're generating, uh, we have the lowest cost as well. Um, so, you know, all of his things are. Uh, you know, really exciting, uh, to, to be, uh, bringing this forward. And, you know, what this means at the end for the consumer is that, uh, we can go much more beyond Biodel Tupelo age.

[00:23:31] Uh, and because we collecting and, you know, archiving your epi genome, over time, I, I'd unprecedented resolution. We can go and build biomarkers for many other things, right? So this story doesn't end in biological age. Biological age is. You know, why not? Oh, people are being  by , which driving forward this, uh, this interest in epigenetics.

[00:23:54] And that's fantastic. And we're really excited to also be providing that. But there is much more beyond [00:24:00] biological age.

[00:24:01] Carl Lanore: [00:24:01] I, I have very little interest in knowing what my biological, biological ages, because I have a face, like an old shoe. So knowing that my insides at 25 doesn't mean something, but what means something to me is that I can stay.

[00:24:16] Active and engage in life until the last heartbeat. That's more important to me. And that means eliminating insults as I go through this journey. But I can't navigate around those insults if I don't know what they are in the first place. So this, this is, this is so exciting. So what about transgenerational?

[00:24:38] So what I know about my epigenetics today. Will it reward my children in some way? Let's say a, can I say to them, we don't do good with this and this is better for

[00:24:49] Dr. Daniel Elías Martín Herranz PhD: [00:24:49] us? Well, that is a very interesting and also complicated question to, to answer so that, let me, let me take a step back and let's, let's rethink [00:25:00] about, you know, how inheritance essentially happens.

[00:25:03] So, you know, obviously. We pass down our, our genes, our core genetic information, uh, and everyone is familiar with that. And now the question is, can we pass it on? Also, these epigenetic marks, uh, the data attached to, to our DNA on the regulate power DNA is being read. And that can also be out there by lifestyle environmental factors.

[00:25:25] So what happens to in development? So when this pheromone, the yang come together on form OSI goads uh, you know, what happens. From that sale until we become a multicellular organism is that, uh, you know, the something known as separate, tended reprogramming, uh, go sown. And what that means is that erases, uh, previous memories, uh, you know, from, from those cells.

[00:25:49] So either racist, previous epigenetic information. So you kind of started life fresh, right? So having said that, um, you know, there are many things that can happen while you are in the womb of [00:26:00] your mother. Right? So if your mother is smoking while you're in the womb, if your mother is having a specific type of diet when you're in the womb, uh, those, those type of conditions can also affect the epigenetic profile of, of the baby that that is, you know, being, being developed at that time.

[00:26:17] I'm, you know, those epigenetic marks in that sense. Uh, if they're not being inherited, but they are, you know, being. Pass it down in an indirect way to achieve the next generation

[00:26:28] Carl Lanore: [00:26:28] course because they're shaping the environment that the, that the, the baby is growing in. That's brilliant. So that means that mothers who are planning on getting pregnant should know

[00:26:39] Dr. Daniel Elías Martín Herranz PhD: [00:26:39] their

[00:26:40] Carl Lanore: [00:26:40] epi genome so that they have a better influence when they build that human inside them.

[00:26:47] Dr. Daniel Elías Martín Herranz PhD: [00:26:47] Well, it's always better, yeah. To, to be out there, you know, the peak of your health, uh, when, you know, when you're trying to have children. Uh, and you know, ideally you want to do that. I think it's important to mention for the people that, you know, this [00:27:00] is when people talk about, for example, transgenerational epigenetic inheritance, uh, for that to actually be true.

[00:27:07] Those hippy genetic marks will need to be passed down beyond two generations. So even beyond your grandchildren, uh, there are, you know, different reasons why that's the case, uh, by basically, you know, it needs to be proven that it goes, you know, way beyond many generations. Somebody used to stable epigenetic Mark.

[00:27:24] So in humans to this date, there is no strong evidence yet then when straight in that, uh, but we do have some evidence in model organisms, right? So it is not unthinkable. That this could be happening in humans. A buddy used to steal the early days to be, you know, to know if that is the case and you know, why do you stay in Fox four for our health?

[00:27:47] But certainly, you know, they're in development. There can be AB genetic effects that, uh, you know, can affect your health later on.

[00:27:55] Dr. William Seeds, MD: [00:27:55] And, and that's in Carl wa, what Danny is saying is so important [00:28:00] because clinically. We see this issue right now. If we just take diabetes as a problem type two diabetes, you know, we can correct it through glucose control and think that we've got  right, and glucose.

[00:28:14] Right? But the Progenity of those people actually have an they, they do pass on some clinical aspects of also dealing with diabetes where the genetic code may have not. Pushed it that way, but these epigenetic changes, these methylation changes actually have done something to influence the Progenity moving forward.

[00:28:38] And that's where, this is so fascinating.

[00:28:40] Carl Lanore: [00:28:40] Um, no, I know in the clinic, and we, we've actually done, we did a show, uh, which basically the summary of it was don't, the mother and father shouldn't be deep into ketosis when they produce a baby, because that baby will be built under an assumption. That the environment it's coming [00:29:00] into is, is, is different.

[00:29:02] That, I mean, w I understand what you're saying. It's really amazing. It's, it's, that's why I was curious about epigenetic transference and it makes sense that the mother should know at least what's good for her body because the child will be built under that blueprint, so to speak. Uh, so dr seeds. Does the epigenome act on the gut?

[00:29:24] Does the gut influence the epigenome? You know, there's this, there's these two cosmos right now, right? There's the genetic, and then there's the microbiome. That's so fascinating. Some people think the microbiome is simply a remnant of your diet. Others think it actually drives things as opposed to being a passenger.

[00:29:44] How does that, how does the gut play into this whole epigenetic testing.

[00:29:51] Dr. William Seeds, MD: [00:29:51] Well. Absolutely. So just to make it simple, the , and I hope I do this correctly, the [00:30:00] anything that, uh, in the GI track, um, and if we're going to use the GI tract, the gut and the microbiome absolutely influence cell metabolism. They influence cell efficiency.

[00:30:13] They, it influences the immune system. All of those aspects work together. To make a sell efficient. Well, sell efficiency, all has to do with utilization really coming down to utilizing oxygen the best it can and making ATP and NAD, and if we're, if the cell loses that ability of metabolic flexibility, you start to get this signature change in how the cell may be working against.

[00:30:48] The, the changes in the gut, let's say that that may be affecting DNA repair, um, things that are necessary to keep the cell [00:31:00] cycle going. Okay. And, and if that, if all that isn't working, then we can get a backup in the Krebs cycle and we can get things that start affecting. Methylation and demethylation.

[00:31:14] And that is very important because that signaling is what controls how a gene transcribes a message to produce proteins to produce the changes the cell requires. So just nutritional changes, like alteration of the microbiome can start that epigenetic signature. And can change the phenotype of the cell to where methylation changes or demethylation as I like to look at it, um, of, of his stones.

[00:31:53] Uh, and, um, DNA. Um, the DNA is chemical alterations and the [00:32:00] histones are more post-translational changes. But what happens is you get a change in the epigenome and. And that's what we're talking about. So absolutely. That's why this is so fascinating. And this is why it's just, I mean, we could, Danny and I could probably start talking now until next week, and we were barely talking because we're coming up with ideas and things that we have to do to change the world because this is what's going to happen.

[00:32:27] This is what's going to happen, Carl, with this information.

[00:32:29] Carl Lanore: [00:32:29] So exciting. So if you are listening to this and watching this on Facebook, and you're as excited as I am. Uh, listeners of this show have an unprecedented offer. You could save 70% off. If you go to , C, H, R, O,N , O, M, I, C, s.com/dr hyphen, S, E, E, D.

[00:32:53] S. for those of you on Facebook, you can see the link and you can actually get this [00:33:00] normally $1,040. You can actually get it right now for $299 to the first 500 people, because we really had to work hard to get this deal and thank dr seeds for it to your, for your, for this audience, this is a, this is an unprecedented opportunity for you to learn what your epi genome is.

[00:33:23] Uh, we, you know, so many books. So many TV shows and documentaries. So many people have written about what the perfect human diet is. Well, I stopped believing in these, these silos of diets years ago. Now when people say to me, this is the perfect human diet, I run away because we all have different epigenetic influences throughout our life.

[00:33:47] You could be born in the same house with your brothers and sisters. And came from the same womb with the same parents, but because of your individual journeys outside of that house, maybe you expose to something at a [00:34:00] neighbor's house, your brothers and sisters were, your epigenome is different than theirs, so what's perfect diet for you is going to be different than what's perfect for everybody else on the planet because it's unique to you and your journey.

[00:34:16] It's like that jockey on that race horse. He can go the opposite way of all the other horses if he wants to. That's his choice. That is epigenetics. You can finally unlock your epigenome that with the proper management of what you learned will influence your ability to live a disease free and prosperous life for limited time.

[00:34:38] 500 people, two 99 go to chronometer. Dot com slash dr hyphen, S. E. E. D. S don't wait too long. I know a lot of people probably could have do this as soon as they see the show. This is as cheap as getting your, your DNA tested through one of these, uh, you know, ancestry groups or something like that. [00:35:00] So much more valuable, so much more valuable.

[00:35:02] We're going to take one quick commercial break. We'll be right back with more. Stay tuned. Lots of good questions. I'm going to ask the hard questions. Is anybody looking at. What Metformin and rapid myosin are doing when we come back. Evolution just got kicked up a nudge.

[00:35:23] welcome back to superhuman radio. We're talking about something very exciting. Oh look, I'm on the other side now.

[00:35:36] Talking with Dr. William seeds and Dr. Daniel Elias, Martine heroines, and, uh, I'm a, I'm a big, I always try to pronounce people's names right. Poor Alisa, her name is so easy, but few people get it right. It's, I feel bad. So I always try to pronounce the names right. So. What about, uh, some of these, uh, [00:36:00] supposedly  dr seeds, you and I are fascinated by them more so I don't know that Danny follows a lot of them.

[00:36:06] Are we seeing anything? Uh, Oh, well Danny would know. Are we seeing anything from any type of epigenetic testing that these drugs actually, especially Metformin. That's the one that bugs the hell out of me. Are we seeing that this is really working for people?

[00:36:21] Dr. Daniel Elías Martín Herranz PhD: [00:36:21] Yeah. No, it's, I think it's a, it's a really, it's a really interesting question.

[00:36:25] Uh, maybe I can, I can get started doctor seats and then you can jump in if we just don't get any time. Um, so obviously I'm not a medical doctor. Um, so for that purpose, dr seats will be able to give you better advice than myself. I can talk from where, you know, the science say side in terms of, you know, while we know about this analytics, the biology of aging, et cetera.

[00:36:46] So, um. You know, obviously over the, over the last years, uh, people have defined this different, what they call whole marks of agent, which are things that are happening at them or that career level, uh, that we observe, you know, happening during [00:37:00] age and in, in many different, you know, species on one of those things is that our tissues accumulates the nets and cells.

[00:37:07] So these are kind of some B cells. That, you know, get, they're kind of stuck, we felt divided in and they start to produce a lot of like inflammation and inflammatory marks. And that obviously, you know, the increases, uh, the ability of our tissues to, you know, regenerate, uh, onto a sensitive, performed the function to stay healthy.

[00:37:27] So there are people developing drugs known as scintillate six that target this, this senescent cells. Um, I know, obviously the, the key question is. You know, the, we see anything on the level of biological age, uh, after the, after this drugs are applied. I am. You know, the reality is that it is very early days.

[00:37:45] Um, so there are, you know, very, very few clinical studies, uh, that have been like performing this. And to my knowledge, uh, steel that has him being like an assessment of the impact of that, uh, in biological age class [00:38:00] measure using epigenetics. Uh, but obviously it's something that we are very much interested in.

[00:38:04] I know, obviously, you know, Beyonce analytics, there are other things like, you know, my foreman, uh, rapamycin, et cetera, uh, which are very promising. A anti aging truck candidates, uh, that, you know, people are starting to study now and, and tried to apply to, I mean, the context of agent

[00:38:20] Carl Lanore: [00:38:20] dr sees, has anybody taken a person who's been on rapid myosin, which you and I are fans are because it's not continuous or even like longterm Metformin use in healthy individuals, not in

[00:38:33] In diabetic individuals and just done a, you know, a, a plug biopsy on them to see if a before and after there are less, uh, cinematic cells in their, in their tissue.

[00:38:45] Dr. William Seeds, MD: [00:38:45] Uh, so, so the not specifically like that, um, it's been looked at from the oncology side of looking at, uh, at, at how it can stop. Because, [00:39:00] because it, it works a different way, uh, in a tumor cell.

[00:39:03] But, um, let's just say for general purposes, no. And let's go back to what Danny said, that this is what, so, so this is what we believe. Um, this is the basis of. Of everything we're doing now. This is what we believe. This is what aging is. We believe this is what disease is, is this buildup of senescent cells.

[00:39:28] And this is why this is so incredible with the research, the research that we're moving forward with now because, and I, I'm, I hope you don't let me steal your thunder here, Danny. But the other work that, uh. That has recently been done where where you guys were, we're looking at single cell at STEM cell, right?

[00:39:51] It's STEM cell. Epigenetic changes is where the key is, and because the STEM cell is so important in reviving the process of [00:40:00] senescence, and the more information we have on single cell changes, that's where it's going. And this is what's so beautiful about chronometer. These guys, I mean, we're all about looking into the future of where, what are the next steps and where we go and, and senescence is everything.

[00:40:19] And to being able to tell how we can stop or slow down, either by modulating senescence or eliminating senescence to some degree, um, through the immune system and through, you know, through what your body can do. This is where it's all gonna come together. And. And I, I, I mean, I, I've got 50,000 studies in my brain right now with, with where, where we're going with everything here.

[00:40:44] It's just a matter of Danny and these guys know they got to keep up with me because we've got a lot to do. We've got a lot to change in the world and, and, but, but these guys are brilliant. And this, this, uh, STEM cell stuff is, is beyond. Um, but let me go [00:41:00] one more step here. I think we need to make something very clear and I'm going to let Danny take it from here.

[00:41:06] I think the most important, one of the most important things when we look at this and we look at the responsibility of what are we doing with looking at our epigenetics and this data is I would like Danny to explain the measures they've taken. To protect this data for the individual because to me, that was one of the most important things I looked at

[00:41:29] Carl Lanore: [00:41:29] and I,

[00:41:31] Dr. William Seeds, MD: [00:41:31] I, I think we should, we need to talk about that.

[00:41:34] Carl Lanore: [00:41:34] You mean privacy? Likely, like, like everybody's worried that did 23andme that then when they were sold to some pharmaceutical company and all that data was going to go and be used somewhere. You got, you're talking about right, doctor fees.

[00:41:45] Dr. William Seeds, MD: [00:41:45] Yes.

[00:41:45] Carl Lanore: [00:41:45] So Danny, speak to that.

[00:41:47] Dr. Daniel Elías Martín Herranz PhD: [00:41:47] Yeah, absolutely. So obviously I'd coroner makes, you know, part of our core values is really that they're the end user.

[00:41:54] So, you know, you own your own data and you are in absolute control of it. So that's what we [00:42:00] believe. Uh, and for that, you know, we have, uh, basically the stuff put in place. So to ensure maximum data privacy on, on security. And it's not only that we say it is souls that, that, that is the legal framework.

[00:42:14] Under which we operate. So we are a European company. Uh, and in Europe we have their most comprehensive on protective law in the world for data protection and data privacy for the end user is known as GDPR. Um, so what this means is that on the whole purpose of this, as I said, a stupid. The end consumer in absolute control of the data.

[00:42:36] So you own your data. We have stored it for you. We give access to it for you by you own it, and you decide what is going to be done with, with your data. So, in that sense, you know, the way that it works with Ranomics is that, uh, you know, when you use our services, uh, you have a very, very. Uh, you know, concise consent that we are giving us for how we can use, uh, that data.

[00:42:58] So we can only use that data [00:43:00] for giving you product and services, um, to doing internal research, always with the data completely. I know any mice, uh, in order to keep improving our products on, give you, you know, newest stuff on new biomarkers. So if at any point, for example, let's say that Pranav mix wanted to do, I studied with a university where we wanted to use part of that and only my stator, then everyone of our users, uh, will need to give explicit opt-in consent for that to happen.

[00:43:27] So what that means is. You know, like it's completely, it's completely control. You're an absolute charge of it. And if at any time you want to contribute, for example, for research, then you can opt team for that, for that purpose if you wish. Uh, so this would be really  option to control by how your daytime, when you use, uh, I know.

[00:43:49] So, uh, you know, I'll wait to ensure that that is secure. Uh, I'm, that you can not succeed whenever, whenever you want.

[00:43:56] Carl Lanore: [00:43:56] How does that compare to HIPAA? Doctor feeds.

[00:44:00] [00:44:00] Dr. William Seeds, MD: [00:44:00] This is a step above HIPAA. Okay. This is, this is more ads. Actually, Europe has more stringent rules than we have here in the U S with HIPAA.

[00:44:11] That's a very, that's a very significant point. Bring up and, and that's something that's, you know, the American companies here. That's the problem we're plagued with here in the United States, is that the American companies have made deals with giving your data out to people. I mean, that's part of why, that's why you, that's what happens in the U S and, and, and that was something very important to me to understand with this, the core concepts of how this company was founded and what they believed in.

[00:44:40] And I, I mean, I, I think that says a lot right there.

[00:44:44] Carl Lanore: [00:44:44] Dr seeds. Recently, you and I were talking about a study that looked at CT scans of the brain in a low carb environment, and it showed that the, uh, the aging of the brain can actually be reversed by a, by a low carbohydrate diet. Do you think [00:45:00] that, uh, when we start to dig deeper into epigenetics, we're going to find, I mean, so much, so much good research.

[00:45:06] Let me back up. I did my first show about, um, glucose signaling and cell senescence. In 2007, uh, with a scientist from Rutgers university. Um, everything seems to trickle back to managing blood sugar levels when we talk about senescent cells, and that's what a lot of these Metformin and these types of drugs seem to have an influence on.

[00:45:32] Um, do you think that we'll get to learn more or are we going to just validate that a low carbohydrate. A diet seems to produce better outcomes for humans?

[00:45:45] Dr. William Seeds, MD: [00:45:45] Well, I think we're just going to have more data to make decisions about. Again, it all comes down to the cells ability to have the flexibility of choosing its substrate, whether it's fatty acid, glucose or protein and it, and we [00:46:00] are, we are not at that level yet.

[00:46:02] Understanding how intelligent that cell is. Depending on its environment and how it utilizes the substrate at the time to take care of the needs of the cell. But, you know, grossly we know that improved use of, of the mitochondrial respiration with fatty acids and, um, and some glucose, uh, through the, um, going through the mitochondria.

[00:46:31] Is the most efficient means of producing ATP and NADH or NAD with the least amount of free radicals in those things that, you know, as a, as it becomes efficient. So all that, that's what that's all about in the brain, in the brain, it's, you know, it's, we've learned that, well, maybe there is re we've learned a couple of things that the brain does utilize glucose.

[00:46:58] That the brain [00:47:00] has this potential of become insulin resistant. Outside of the body, and this is where all of this process has gone with ketone esters. Why ketone esters? It becomes so brilliant for brain disease, brain trauma, issues like that because we can, we can bypass, right? The utilization of glucose initially while we start improving the efficiency of the cell.

[00:47:25] So the epigenetics, if we think about it, the epigenome has changed because of that. Cell senescence is present because of that. So we have now some real ways to validate. So many things we could not follow before that are, are overwhelming. And let me just add this. Um, you know, so this is interesting cause you, you know, Betsy, uh, uh, your zero well, okay.

[00:47:52] That is one of my esteemed colleagues and Betsy and I always have incredible discussions about where are we going in the future. [00:48:00] And, and this is, this is what's, I think everybody should look at it. And, and Betsey's headed down a brilliant pathway also. She's looking at the proteomics side, right? What, what's the downstream part of the, uh, of the data?

[00:48:16] We're looking at the upstream part. They're both, we're, we're both right. They're both the right patterns, but, right. But this is kind of the hierarchy. This is the area where we're starting, but. Well, the principle thing I wanted to make here was that we're all looking for the same thing. And the cool thing is we're going to have so much data coming at us that it's going to change the way we look at health, nutrition, medicine, um, at life.

[00:48:47] And I, I, there's just not enough time in the day to talk about all the things we can that we're going to move forward with. Uh, but, uh. You know, especially if Danny and I are allowed to keep talking. It's a bad [00:49:00] thing. We just,

[00:49:03] Carl Lanore: [00:49:03] okay. I want to ask one more question. We're going to take a break and when we come back from the break, we're going to talk about how to assess your risk of coven 19 because that's available on the website too.

[00:49:13] So there are people out there claiming to have epigenetic testing. Daniel, how is this different? This, this is very different than anything else that's been available before. Right.

[00:49:26] Dr. Daniel Elías Martín Herranz PhD: [00:49:26] Yeah, absolutely. I'm happy to give you some examples of what makes us different and what we think it is, you know, the most comprehensive epigenetic testing the world.

[00:49:36] Um, so I think we discussed before a bit about the technology. Uh, so we're the only company out there that, you know, it's assessing both the quantity and the quality of the data with, with next generation sequencing. Uh, so your de facto creation, you know, the most accurate. It'd be genetic picture if you wish of yourself, uh, available to date.

[00:49:57] Um, there are also aspects about, [00:50:00] you know, this becoming because of the data that we're generating, uh, you know, the most cost efficient way to actually measure your epi genome. Uh, and this goes all around, this idea of, of digital digital twins, right? Creates in, you know, our version of yourself where you start to collect more and more data.

[00:50:17] So if the receipt says I'm being able to offer a really accurate version of this, um. And the next thing is about while we actually give to people. So you know, the rest of the other epigenetic tests out there, they're only offering biology equal age. Um, so we obviously offer a biological age as well, but our vision is to go much beyond that.

[00:50:36] So we want to measure, as I said before, older main risk factors for the development of things such as different types of cancer that you, diabetes, you know, narrative, narrative. They sees cardiovascular disease. So these are all things that have common risk factors to them. And if you really want to do true preventative healthcare, you need to be able to measure this risk factors and act with specific interventions to reduce [00:51:00] them on that half of the way to truck, if that work or not.

[00:51:02] So we measure health and wellness, uh, through, you know, what we call other epigenetic indicators. So for example, we measure, uh, your, uh, metabolic risk, uh, which obviously, you know, we, we discussed this a second ago, how important metabolism is in the context of, you know, epigenetics, but also your health. Uh, so we can detect, I'd be epigenetic level.

[00:51:22] What is your metabolic risk? Uh, and that is obviously very associated with things that's, as you know, metabolic syndrome, type two diabetes, et cetera. Uh, we can also quantify exposures to a specific factors so we can quantify how your body's reacting to your alcohol consumption. We can quantify how your body has been exposed to the chemicals found in, in tobacco and air pollution.

[00:51:43] Uh, and these are all things that, you know, really measuring yourself  grow level. So, you know,  all these things are different types of four different sources of risks that eventually, uh, can lead to two different types of, of diseases. So like, once you find this, I'm going to be [00:52:00] yawned. Uh, you know, H S associated risk, which is what their biological age, uh, you know, biomarker is doing.

[00:52:05] Uh, we can get a very comprehensive view of our health. Uh, I have no solid way to quantify the specific interventions that will work. For each one of those things. And yes, to say, obviously we keep doing an auto far and D, a lot of scientific research. Uh, we're really excited about bringing forward, you know, the fields.

[00:52:23] And that's the reason why, you know, with this data said, we keep expanding in the biomarkers that we offer. So we're the only company out there that is really trying to push the limits of what is possible, uh, with epigenetic data in terms of biomarkers. Uh, and yes, so you guys know where we need, for example, interested in mental health.

[00:52:40] Uh, you know, and obviously in specifics about about diet and exercise and sleep, et cetera, et cetera. So there is much more, uh, coming out. And the good news is that because you collected these very accurate, you know, picture of your epi genome, you can also retrospectively go back and look at this things as more and [00:53:00] more things are being discovered.

[00:53:01] So

[00:53:02] Dr. William Seeds, MD: [00:53:02] that retrospective thing is huge. Carl,

[00:53:05] Carl Lanore: [00:53:05] I know, being able to go back and say, Oh, we learned this now let's go look at your situation. Uh, I'm hoping it's Casey cause he has Casey and Alicia Moro. But I think Casey is the one who listens to the show. He says, uh, basically, uh, are these, uh, reports self interpretable or do I have to bring it to a doctor and pay a doctor to tell me what the report says?

[00:53:28] Dr. Daniel Elías Martín Herranz PhD: [00:53:28] Yep. So we've done a lot of work, obviously to bring this to you, to the people, and you know, the platform that we have for, for consumers for the year series. So you basically just log in, register, and then you will be able to access all your results online. And you know, it's self, it's self explanatory. So we've made a lot of effort to explain.

[00:53:47] You know what this means, what this is. Uh, I'm, you know, to make sure that people get all the value out of, uh, out of these insights. Uh, and there is also the possibility to, to share this, for example, with your doctor, [00:54:00] uh, or your coach, uh, if you want to, you know, either additional insights into it. And we also provide a training to a lot of this.

[00:54:07] A. Uh, you know, coaches and doctors, et cetera, et cetera. So, you know, both options are possible, but essentially, uh, you know, you can, you can just go and undo it and see your results by yourself.

[00:54:18] Carl Lanore: [00:54:18] See, and that's important. I would rather be able to go to my doctor and say, you need to know this about me than handing it to him and say, tell me what this says.

[00:54:28] So I like that because you can influence how your doctor treats you, but you don't need your doctor to interpret it.

[00:54:36] Dr. Daniel Elías Martín Herranz PhD: [00:54:36] That's the bottom line, right? That's right. Yeah. I mean, obviously, you know, it's always better. I think if you have someone that that guides you through it, it's always going to be better to offer a second opinion in the way that you interpret it.

[00:54:50] And that's why, you know, we work a lot through through clinics and, you know, different doctors, et cetera. But you can access the, you know, the report. I'm just understand, uh, you [00:55:00] know, the key things on the main sites as by yourself.

[00:55:02] Carl Lanore: [00:55:02] Yeah,

[00:55:04] Dr. William Seeds, MD: [00:55:04] that's absolutely what we're going to do through our site, through the seeds MD, is we're going to be there to help everybody with this.

[00:55:12] We're going to make this simple. This is, this is a relationship that's gonna continue and move forward in many different ways. So. We're ready.

[00:55:21] Carl Lanore: [00:55:21] So, and Casey says a yes. That's what he was hoping to hear, so that's wonderful. Yeah, that's what I'm hoping to hear too, but that's nice to know that we're going to have support.

[00:55:29] So I want to put a couple things up here. We're going to take a break. When we come back, we're going to talk about how the site can help you determine your own risk for coven 19 so two things I'm going to show you. You can get 70% off of the normal price for this lab work. Uh, by going to , C, H, R, O,N , O, M, I, C S.

[00:55:50] dot com slash dr hyphen seeds for dr seeds, uh, that it represents 70% off, brings you down to [00:56:00] $299. It's only available to the first 500 people that take advantage. Now keep in mind this show, once it hits the podcast network, it stays out there for years. So don't give up because there may be people who didn't.

[00:56:14] Decide to take advantage of it. And then maybe a few more slots, but first 500 people, only $299. And then also, uh, as we go into a talk about, uh, Cobra 19, I'm going to share a blog post, uh, from dr seeds, his website, a I, different way of looking at protecting yourself against, uh, this, uh, this virus. We're going to take a quick commercial break.

[00:56:37] Stay tuned. We shall be right back.

[00:56:45] Complex today. This is the superhuman channel where we use oxygen for the power of good

[00:56:55] welcome, man. So a couple things. [00:57:00] First of all, if you go to the URL for

[00:57:05] Dr. Daniel Elías Martín Herranz PhD: [00:57:05] the product

[00:57:07] Carl Lanore: [00:57:07] for the testing. Which is a chronometer.com forward slash dr C, dr hyphen seeds, DRL hyphen seeds. You can actually test by answering some questions, evaluate your own risk to contract Cobra 19 Daniel explained this, uh, how does it work?

[00:57:28] What does it, what does it based on?

[00:57:30] Dr. Daniel Elías Martín Herranz PhD: [00:57:30] Okay. Yeah. So obviously, you know, it's, it's early days in how we understand this disease and, and this infection. Um, but we know that they're, you know, certain risk factors that predispose you to, you know, either get more infected or, you know, if you're getting infected, recover successfully from, died from died, uh, infection.

[00:57:50] And, you know, some of these factors are things like, you know, your age, your sex, uh, preexisting conditions such as cardiovascular disease, hypertension, diabetes, et cetera. [00:58:00] Uh, so while you can do with this questioner, uh, very quickly, is to determine, you know, in which category of risks. You are, I know. Also learn more about, you know, why you can do what you can do about it and understand that bit better.

[00:58:12] You know, the type of measures that you can do to, to avoid a Colby 19. Uh, so it's, it's about, you know, making people understand if they are in a risk, uh, you know, you know, you know, risk or taggery and also, uh, you know, what they can do to, uh, to try to, to avoid it. And

[00:58:30] Carl Lanore: [00:58:30] then dr. Seed, you just wrote an interesting article.

[00:58:32] Then we've got another question from Casey moral. I want to bring it up here because it's gotta be, it's, it's, it's one I didn't think of, and we're probably going to see more like this. You have a This email address is being protected from spambots. You need JavaScript enabled to view it. forward slash blog that talks about a very simple ingredient that most of us have in our cupboard that actually has the potential to help protect against the replication of this virus.

[00:58:52] Right.

[00:58:55] Dr. William Seeds, MD: [00:58:55] Yeah. It's just a very simple, quick introduction for people that don't [00:59:00] understand or don't have the knowledge of a acid based metabolism of the cell and understanding redox of a cell and just some of the very simple things that in your cabinet you have the potential of utilizing sodium bicarbonate.

[00:59:16] To help maybe give you a leg up on, on potentially stopping what happens in the cell with viral replication. And you know, what most people don't realize is that this American diet, the things that we do here in the U S is you're kind of already set up to be in a low grade metabolic acidosis. And, and we've, we've proven that, we've known that since the late seventies and, and this is a way that you can actually.

[00:59:46] Do something to help, again, that cell efficiency that you so desperately need when this process starts. Uh, you know, taking hold and, and what's amazing about this, Carl, is I've, um, so I, [01:00:00] I've released this through the IPS through our thousands of docs, and I'm getting so many messages right now, especially some are people in New York city that are, they're just.

[01:00:10] Doing what they can to use bicarbon. We're turning people around with fevers, cough, chest pain that, you know, can't get tested. But within 24 to 72 hours, we're helping people. And, and you know, what are the more sophisticated ways. Absolutely. But you know what, in times of need and something specific like this, it's happening in the world.

[01:00:34] Carl Lanore: [01:00:34] My gosh, not everybody has access to Thomason alpha one, you know.

[01:00:39] Dr. William Seeds, MD: [01:00:39] Well, yeah, the peptides is a whole nother deal, but this is something everybody can take advantage of because as you know, we know in the sports world by carb is a very powerful, uh, uh, it's a very powerful ergogenic. Um, ergogenic. Yeah, absolutely.

[01:00:57] We know it. We've proven it and we've made [01:01:00] all the mistakes with it and, and the literature is vast in that, but. You know, it's, there's just not enough time to talk about it. But I go through some things to help people maybe tentatively understand what they can do.

[01:01:14] Carl Lanore: [01:01:14] So Casey, um, wants to get it for three people in his family.

[01:01:18] He said, even at the 70% off, that's $1,000. Is there a way to contact them about payment options? He claims that he's already reached out to the site. I don't know that anybody you're going to reach Casey knows about this special deal. Uh, they may even be confused about it. And I know Daniel. Is a scientist and he's not the business guy, but, um, is there anything we can do for people who want to have their entire family tested?

[01:01:44] I mean, I know we're already down in the dirt with this, um, payment options or anything like that. Maybe Daniel, you can pose that question, uh, to the administration people and, and, and get an answer and I'll promote it on the show. [01:02:00] And the next day or so, cause I have a feeling, you know, we all love our family, right?

[01:02:04] I'm not going to do this by myself without doing it for Elisa. I'm like, no, no, I'm going to do this. You can go get your own. So we're going to end up having people who have to, they want to have their entire family tested because this is a ridiculously cheap price for this. This is like stupid cheap. And like I said, it's 500 and it's over.

[01:02:22] Um, so maybe we could get some answers for people who want to buy multiple units.

[01:02:28] Dr. Daniel Elías Martín Herranz PhD: [01:02:28] Yeah, absolutely. I mean, obviously I'm not in Apple system at the moment. T T you know, uh, say that for sure. And as you said, I'm the science guy, so I'm guessing interested in, you know, giving this test to as many people as we can and then, you know, improving health span.

[01:02:41] That's, that's my goal. Um, but I think in that sense it's probably easier, yeah. To contact us actually through our, through our sites, uh, on there, we will have people that will be able to, to help you with, uh, with your question. Very,

[01:02:55] Carl Lanore: [01:02:55] very exciting stuff. I am really excited. You know, I, I gotta [01:03:00] tell you something.

[01:03:00] I was talking to Ron Penner the other day, and he, you know, he, he's always amazed by the fact that this show just keeps producing more and more great content. And he said, I know what it is. He says, it's your, you're so, you're still inquisitive, but I'm inquisitive for very selfish reasons. I have my demons that I want to fix.

[01:03:22] And I believe I can fix them. And today's show has given me new optimism because right now the way I'm trying to fix thing is, you know, I'll try this and see what happens. I'll try that and see what happens. I'll try this and see what happens. And maybe the thing I really need to be trying isn't even on my radar.

[01:03:41] So I've, I this, I really find that this is a discussion of, of hope. And change because maybe we'll actually be able to get some answers. Look at this. Michelle Canela Melton said [01:04:00] she just ordered one. Thanks. So there you go. It's going to, I'm telling you. My nipples are hard. I'm so excited. I'm sorry. I'm sorry.

[01:04:09] Bill is Bill's like, Oh my God, why did I come on this guy's show today? He's covering his face. Hey look, you get me. You get all of me. That's the way it is. All right, so look, this is exciting. Take advantage of it while it lasts. Go to , C, H, R, O, N O, M, I C s.com/dr hyphen seeds. And that is the place to get your testing done at $299 for a small while.

[01:04:41] That's it. You'll see the test is normally a thousand thousand $48. I mean, this is a, this is a real offer and, uh, I'm excited about it. Guys, thank you so much for being here today and talking about this.

[01:04:54] Dr. Daniel Elías Martín Herranz PhD: [01:04:54] Thank you for having us. Yes.

[01:04:56] Carl Lanore: [01:04:56] And we'll, we'll see you again. Okay. Thank you. And, uh, we'll see you around [01:05:00] tomorrow.

[01:05:00] We, you have, uh, renew life RX tomorrow, so don't miss that. Uh, and we'll see you, I think we have a pep talk this Friday. I'm trying to set it up right now. Lots of great shows. Share, share, share the shows, and let's change the world. Really. See tomorrow. [01:06:00]