[00:00:00] Carl Lanore: [00:00:00] Welcome back to another episode of super human radio. Really great show today. You know, uh, we're going to be talking about biological age testing some more, uh, because, uh, there's a lot of people interested in biological age testing, but what do you do after you find out that you're a biological age is a lot worse than you.

[00:00:22] I thought it was, that's the real information. It's like, Hey, we found out how to discover cancer. Great. But if you can't cure it, what good is discovering that you have cancer? So we're going to get into that here in a little bit. I just want to say that, uh, our show is, uh, underwritten by legendary foods.

[00:00:43] Legendary foods has a special deal for those of us who are still sequestered by a Corona virus. Uh, this is day 32 here in Louisville, Kentucky, where everything has been shut down. It feels like forever. Most people are going pretty star crazy. I stopped shaving. What's [00:01:00] the use? Um, eat legendary.com the code relief one five relief, 15 for 15% off all orders, $100 a more.

[00:01:09] This does not include the tasty pastry, which they cannot keep in stock and rightfully so. So check that out. Today, like I said, is day 32 of our local  and it's cold here in Louisville today. For some reason, it's, I guess for those of you in the world of Celsius, it's around nine and a half degrees Celsius, 49 degrees.

[00:01:31] The weather is very, very crazy. Maybe it's crazy where you are as well. I don't know. But anyway. Let's get on with the show. I'm going to introduce my guests today and they are returning to talk about this discussion and that is Dr. William seeds and of course Dr. Daniel Elias, Martine, herons. How are you guys doing?

[00:01:55] Dr. Daniel Elías Martín Herranz: [00:01:55] All right, well thank you for having us called again in this show. It's great to be back.

[00:01:59] Carl Lanore: [00:01:59] Hi bill. [00:02:00] How are you? I'm afraid bill. Can't hear me. This is scary. Yes, something's wrong. Bill. Uh, let me see if I can, um, write a note. Hold on a second. I'm going to, I'm going to text him and tell him what to do. We're gonna, we're gonna take him out of the picture just for a second, and I'm going to have him disconnect and reconnect.

[00:02:25] Hold on one second.

[00:02:28] Dr. Daniel Elías Martín Herranz: [00:02:28] At one their self technology.

[00:02:29] Carl Lanore: [00:02:29] Yes. Yes. Bill, just disconnect and reconnect. We lost your microphone, but

[00:02:36] Dr. Daniel Elías Martín Herranz: [00:02:36] see if he gets that text

[00:02:37] Carl Lanore: [00:02:37] message. Uh, anyway, so we're going to be talking about connect

[00:02:43] Dr. William Seeds, MD: [00:02:43] and reconnect. What do I do that

[00:02:46] Carl Lanore: [00:02:46] the same? Um,

[00:02:52] I have to mute him. He just has to. Yeah. John Joslin is helping him. She'll, she'll get them [00:03:00] squared away. And, uh, so I'm sorry for the, uh, the confusion here. Everybody, uh, dr seeds is disconnecting him. He's going to reconnect here in just a second. So we do know that there are ways to test, uh, people's genetics and even some ways to predict some predispositions, uh, that we're learning about.

[00:03:20] Here we go. Let me get him back on here. Let me get him back on. He's actually fixing his camera.

[00:03:29] Bill. Can you hear me? What happened, girl? Oh, you just dropped out. Your microphone dropped out, but it's all good. You're back. Okay, you're back. So anyway, I'm back on track. So we know that we now have a way to test people's biological age, but it's really meaningless unless you have a way to target changes.

[00:03:50] That will correct the things they've been doing wrong. Daniel, why don't you speak to that a little bit?

[00:03:57] Dr. Daniel Elías Martín Herranz: [00:03:57] Yeah, absolutely. Um, so [00:04:00] obviously, you know, the first, the start to know if something is working is to be able to, to measure, to measure it. Right? And you know, the problem that we have now in preventative healthcare in the wellness space is the fuck died.

[00:04:15] You know, we're lacking accurate measurements of health. Ah, so accurate measurements of, you know, where we are right now, even before we develop DCS. And you know what, this deeper interventions are doing 12, we're bodies. So what we do at for makes, uh, with our Epic genetic tests, this died by being able to measure these epigenetic information.

[00:04:36] We can actually capture how your health, he said, woven over time as a function of this different interventions. And I'm sure we'll go now into much more detail into what this means. Um, but the key thing is that we are developing ways to test very accurately at the molecular level, whether all these interventions are working for you in a data driven way.

[00:04:58] Carl Lanore: [00:04:58] And it's important. I want to, I [00:05:00] want to drill down on this cause there's certain nuances here that people take for granted nowadays. So we have people who. Say, um, red wine is good to drink three ounces a day. It's good for you. It protects you against this or protects you against that. And over the past decade, if we've learned anything about nutrition, we know that you cannot apply these types of broad stroke ideas to our population.

[00:05:27] Uh, because we are each unique and the way we respond to the things that we put in our body. Uh, maybe red wine is good for some people. Maybe red wine is not good for some people. And just taking this advice and running with it because someone said it could be a big mistake, but how do you know? How do you know you lost three years of your life?

[00:05:45] You don't have a twin living comparing, well, I did this. They did that. They lived longer. And by the time you figure it out, you're dying or you're dead. So the nice thing about this testing is it allows you to. To, [00:06:00] to critically assess where you are today. Take what knowledge we have about rudimentary changes that seem to help people with certain things.

[00:06:11] Apply them, test again, and see if it's really working. Instead of anecdotally going, you know, I think I feel better. I, I must be working. What do you think dr seeds is that a, a dumb man's, uh, approach to understanding this.

[00:06:28] Dr. William Seeds, MD: [00:06:28] Carl, I couldn't have said it any better. You're teacher, you're, you're right on target.

[00:06:32] You're, we're assessing. We're able to assess methylation changes that are specific to what you're doing to adjust your nutrition or adjust your exercise or whatever. We're adjusting to look at the effects and you have something, you have a baseline to go from. Uh, and to follow through there that there's nothing.

[00:06:59] This is the, [00:07:00] this is the Holy grail for the future of medicine. And this is exactly what we need to make assessments, not based on anecdotal stories, not based on a couple of lab values changing positive or negative, but a true epigenetic changes. Methylation changes that we know alter phenotype of a cell.

[00:07:27] Dr. Daniel Elías Martín Herranz: [00:07:27] That's it.

[00:07:30] Carl Lanore: [00:07:30] Danny, you want to contribute anything to that?

[00:07:33] Dr. Daniel Elías Martín Herranz: [00:07:33] Yeah, absolutely. I mean, I fully agree with dr seats. I think it's incredibly exciting times that, you know, we can measure oldest, different epigenetic markers at the same time. Um, so we measure more than 20 million markers in your DNA. So that's obviously you're not a lot of information.

[00:07:51] If you think about when you do a blood test and you met your, let's say a few. You know, hundred metabolites in your blood, things I, you know, your cigar, your cholesterol, this sort of thing. So we are [00:08:00] measuring 20 million markers, sr DNA. I need one of these markers will react in a specific ways to certain interventions, right?

[00:08:07] With all that data in hand, the first thing that we can do is to quantify the main risk factors for disease. Um, so you know, many years of, for example, something like cancer, according to, you know, the latest studies kind of start even decades. Before he gets diagnosed, right? And many of this molecular processes that are happening ourselves, uh, such as those that happen during age and, um, you know, can be measured.

[00:08:32] Um, they leave a specific, uh, footprint in, in our epi Tinetti quadrants. You know, our DNA methylation patterns. So if we can pick these things up many years before we get those diseases and then try before an intervention specific interventions and see if they work for us. That's a way to, you know, you know, no objectives upon scientific validated way.

[00:08:53] See whether those things are working or not to prevent disease. I spoke, the receipt says that's really the Holy [00:09:00] grail, all of the future of healthcare.

[00:09:03] Carl Lanore: [00:09:03] And what about autoimmunity? Autoimmunity is this nebulous, uh, disease state that encompasses a large number of symptoms from, you know, rheumatoid arthritis and bulging knuckles to destruction of.

[00:09:18] Uh, of the pancreas, uh, or other tissue in the body, the thyroid, the lining of the gut, the lining of the intestines. Are there specific markers that we can see in, in the chronometer testing that would tell us, because it literally takes decades for the gut to start to show symptoms, but it's getting worse and worse every day of your life that you're doing certain things.

[00:09:47] Are there ways to use that early warning and see markers that would point to the development of autoimmunity? Dr seeds?

[00:09:58] Well, 

[00:10:00] [00:09:59] Dr. William Seeds, MD: [00:09:59] the capability is there. Absolutely. It's building. It's the continued building of the, of the population base, uh, to, to be able to correlate that with a certain subset group of rheumatoid arthritis or. A certain subset of lupus or a certain subset of type one insulin, diabetics, the information is there.

[00:10:24] It's just correlating all that and looking more specific at those epigenetic markers, and that's exactly where all of this is going. That's what, that's what's so exciting about this is that we will just, as Danny said, we are . If you can say that about what Danny said about cancer, and we can say that about everything.

[00:10:44] It's about when the cell starts losing its ability to be efficient and flexible, and that's when these methylation changes occur. And so we'll be able to look specifically as we isolate different [00:11:00] population subsets, we'll be able to isolate that. Early on and take significant measures in, in helping people look at how they can change that, that process in that.

[00:11:12] Right, Danny? I mean, you can't get any more. It's all about the devil in the detail, and when you've got 20 million different sites you're looking at and you can sequence the genome, the whole genome, so you can go back. The great thing about this data. It's there. Once you have your footprint, it's there and you can, all as new information comes out and these new markers that we can identify with specific diseases and auto immunities and cancers, you could go back and look at that same original test you did years ago because it has everything.

[00:11:49] There's no test like that.

[00:11:52] Dr. Daniel Elías Martín Herranz: [00:11:52] Yeah, that's absolutely right. And I think you make God great Plains dr seats around these IDL have taken on constructing your, your digital [00:12:00] twin, uh, that I think we've discussed before. Uh, so the fuck to what you're doing is you're taking a picture, the most decorative picture you can take off your epi genome, right?

[00:12:08] And you can imagine died. Epigenetics is maybe now where genetics was five years ago. I'm doing the last five years. There's been a massive development. Uh, in what we could tell, uh, from, let's say, genetic data to what we can do today. Uh, basically, we've, we've gone, you know, from the thousands of people to the millions of people, uh, that we understand their data.

[00:12:29] So that's the revolution that is now undergoing in epigenetics, right? So today we can tell already many things by, because you're taking a picture of your genome right now and you're going to be able to see, you know, hold up changes over time. You're also now have a much more accurate way then. In the future, uh, to see all this new things that we're going to discover.

[00:12:50] Um, so you're, if Facteau, you know, futu future proving yourself in the sense that, you know, you're, you're taking a snapshot show if your health, uh, that will [00:13:00] allow you to, to predict your health much more accurately in the future as well.

[00:13:04] Dr. William Seeds, MD: [00:13:04] I don't think, Carl, I don't think you can emphasize enough with Danny said about, and you've got to give Dan credit with this term digital twin.

[00:13:13] Yeah, that's, that's a real statement.

[00:13:15] Dr. Daniel Elías Martín Herranz: [00:13:15] I know they create their, I must say, but, uh, yeah, I quite like it.

[00:13:20] Dr. William Seeds, MD: [00:13:20] Um, I'm giving you credit, Danny. You got to just say, Hey. Yeah, I agree. That's good.

[00:13:26] Carl Lanore: [00:13:26] So there are lots of people coming forth today with epigenetic tests without talking about them directly and what they have or don't have.

[00:13:39] What makes the chronometer test. Leaps and bounds better than these other tests out

[00:13:45] Dr. Daniel Elías Martín Herranz: [00:13:45] there. Yeah. So I think one of the main things to solve is really the technology that is happening behind the scenes, right? Um, so we use something known as next generation sequencing, which is their latest technology available to [00:14:00] measure DNA.

[00:14:01] Uh, what this means is diet. We're way beyond in terms of both the quantity of data that we can retrieve. So the many markers in your epi genome that we're able to assess. Uh, but also in terms of the quality of that data, and, you know, with that immense data said, uh, then we can go much more, uh, beyond biological age, which I guess is also the topic of, you know, all of this podcast, which is like, you know, obviously biological age is something fundamental.

[00:14:30] Is something super interesting to, to know about your health. Uh, it tells you, you know, how fast. If AIDS until today. And it gives you a measure on overall measurement of your aging process. But there are many other risk factors that contribute to our health and you know, not measuring those would also, uh, you know, be a waste of resources and knowledge that we have out there.

[00:14:51] And, you know, by quantifying Bissau their sources of risk, things I have to do with your metabolism. Whether you smoke or not, or your exposure to the [00:15:00] toxins in the air. Uh, you know, the alcohol that you can see them on, how your body's responding to it, how diet and sleep exercises different things like contributing to your health.

[00:15:09] Uh, you know, we can do a lot more than just spiral to put H both in terms of, you know, capturing, uh, vicinal sources of this risk factors, uh, but also in terms of making this, um, recommendations, much more personalized and targeted to a specific phenotypes. And, you know, that's really the vision behind . We are the only company out there that is really pushing the limits.

[00:15:31] Of what is possible, uh, with epigenetics. And, you know, we're really, really proud to be driving forwards there. The research on these other biomarkers,

[00:15:40] Carl Lanore: [00:15:40] there's another, there's another big deal about this, right? So we just learned this because of the pandemic, right? We've had all these different . A covert 19 tests, nasal swabs, you know, all that.

[00:15:52] But now the big news is Rutgers came out with a saliva test. Oh, that's great. Because this is simpler. People spit in the [00:16:00] tube, they send it in, they get measured. It's, it's, it's a noninvasive, completely noninvasive. It's convenient. It's simple. Everybody can spit. So it's like an, isn't the chronometer product?

[00:16:12] A saliva test.

[00:16:15] Dr. Daniel Elías Martín Herranz: [00:16:15] That's right. Yeah. So why not? The other innovations behind what we do is the fact that we do everything from a saliva sample. Um, and you know, we could go into the science if you're interested on why, you know, a saliva sample. But I think from their consumer side of things, uh, it makes the process so much easier.

[00:16:33] All you need to do is to take this, this tube that arrived, so your home, uh, you know, yes. The speed there for a couple of minutes. And that's about it. And you know, it's Ciro pain. Uh, it's, they used to think that you do, you just do it when you wake up in the morning. Uh, and that's, that's all you need to do.

[00:16:49] Um, so, you know, the process is so much easier on the user experience as you know, so simple, uh, at the beginning, I'm, then you get so much out of that [00:17:00] process. So, um, you know, we are not big funds of a finger pricking, uh, to get your blood or, you know, directly doing it from, from the vein. Um, so, you know, from the beginning we said, look, um, even if we're the first ones doing this hour, we're going to demonstrate that this is possible, uh, and we're going to make it happen from saliva.

[00:17:19] And we had the very first accurate biomarker, uh, that work, uh, that works in aim, uh, to predict biological age from saliva.

[00:17:27] Carl Lanore: [00:17:27] Well, bill, uh, dr C, is it a true that, go ahead. I'm sorry. Go ahead.

[00:17:32] Dr. William Seeds, MD: [00:17:32] I think another point to bring up is. You know, there are, the arguments are, well, you know, number one, we need two blood tests.

[00:17:39] You're not looking at the red blood cells, you're looking at other cells, the white cells that, and, and with the saliva test, what people don't understand is you have a lot of white cells in your saliva, right? So, so you're not only testing the epithelial cells of the saliva, but you're also [00:18:00] looking at the.

[00:18:01] At the white cells too. So you are getting a very comprehensive review that you, you can't refute that. Am I right, Danny about

[00:18:10] Dr. Daniel Elías Martín Herranz: [00:18:10] that? Yeah, that's absolutely right. Most of the people, you know when you talk about sly Bobby, but are not aware that actually most of it is immune cells, a white cells, as you said.

[00:18:21] Um, so, you know, I S I said tissue is not that different from, from black. Um, so, and then he also has the. Um, the benefit that it also captures the Sepi feel, your Google cells, for example. And these are cells that are directly exposed to things I, you know, talk since, uh, that you may breathe, uh, et cetera, et cetera.

[00:18:41] So, you know, that gives an additional, you know, complimentary data type that allows us to also pick up this more direct exposure. So it has, you know, good things about both worlds.

[00:18:53] Dr. William Seeds, MD: [00:18:53] And that part about the toxin thing is very important because you're not going to get that direct effect by taking blood

[00:19:00] [00:18:59] Dr. Daniel Elías Martín Herranz: [00:18:59] samples.

[00:19:01] That's right. Or human need to be very exposed already to be able to detect it because it would have to be a systemic effect already. Correct.

[00:19:10] Dr. William Seeds, MD: [00:19:10] Correct.

[00:19:11] Carl Lanore: [00:19:11] Doctor dr David's Alva came on my show in 2006 and explained that saliva is a natural filled trait of blood. You'll find hormones in it. You'll find the immune cells in it, you'll find cancer cells in it.

[00:19:24] You'll find everything that's found in blood, short of red blood cells in your saliva. And so another reason why oral health is, uh, both critical for help, but also indicative of what's going on inside your body. With that being said, if somebody is suffering from ginger Vitus gum disease, does that skew the potential results that we'll see from this test?

[00:19:50] Dr. Daniel Elías Martín Herranz: [00:19:50] That's a great question. Yeah. So we obviously correct for all these things. Uh, our biomarkers are robust, uh, to buy reagents that made you to other the courses that are not the [00:20:00] thing that we are, uh, picking up. Um, so while we're biomarkers correct for all of these things, but the interesting thing is that, you know, if you opt into byte is, uh, that's be something quite interesting to also from us.

[00:20:12] See how that evolves over time, right. In itself. Um, because at the moment, the way that we think about gen Z Vidas it's actually like a binary thing. Right? But, you know, it's, it's a thing that also develops over time and it doesn't happen suddenly. Yeah. Um, so that's also an area of interest, uh, for us, because that's, that seems feeding that into teach you that we are actually sampling,

[00:20:34] Carl Lanore: [00:20:34] um, if someone is thinking of getting 23 in me because they want to know what their heritage is, uh, that's obviously a novelty and of interest to people.

[00:20:44] Uh, but obviously having a blueprint of your, your, your digital twin, as you like to say, is much more valuable to the out out, uh, the, the turnout of your life. But if someone was going to go get 23 and me, and they thought, gee, I can get [00:21:00] 23 in me where I can afford to get this, can they do this instead of 23?

[00:21:05] And me? Do you offer any type of, uh, uh, uh, ancestral information in this research?

[00:21:13] Dr. Daniel Elías Martín Herranz: [00:21:13] So we offered, the main thing that we offer on what makes us unique, uh, in the world is our epigenetic tests, um, that we send worldwide. We decided to, you know, I started, uh, on IPI genetic testing company is because it allows you to, first of all, see how these things change over time.

[00:21:30] So genetic information is fixed as soon as you're born. While it be genetic, information will change the function of your lifestyle. So, you know, that obviously captures many things that I, genetic test. It's missing on. The other thing is because he changes over time, it also is much more actionable. Um, so the fact that I tell you, you know, from bearer the alpha 20% risk of developing a type of cancer, you know, some people might want to know that.

[00:21:56] Um, but in some cases there is not much that you can do with that [00:22:00] information. Right. Um, well, I think the case of epigenetic data, you know, by knowing your values of all these different risk factors, you can action them through a specific interventions and then see if they work or not. Uh, now having said that, which is what separates apart from, you know, uh, genetic testing companies and the reason why we started with Colonel mix and we were excited about this and, and the positive message behind epigenetics, um, we also, for whole genome testing.

[00:22:25] Uh, for those people that are interested so we can provide a sequencing of, of the entire genome, uh, as well as the complimentary, um, surveys by, you know, what really differentiates us from the rest. I'm, you know, what we want to really get people excited about if the epigenetic tests,

[00:22:43] Carl Lanore: [00:22:43] uh, we have a question from Larry over at unique medical.

[00:22:45] He says, can we leverage this data to treat our patients and provide precise treatment? There's a second part to this question. Uh. Specifically with the use of peptides. So can this, can this data that [00:23:00] is obtained help a physician who is using peptides to treat their patients, know which peptides this patient is a candidate to use?

[00:23:10] Dr. William Seeds, MD: [00:23:10] So, so this goes, so that, that the answer to that question is, is hello Larry, by the way, is that this doesn't just cover peptides. This covers any intervention. That's, that's what's so amazing and important to understand. Any intervention, supplement, exercise, diet. I mean, you can dial it in. So absolutely.

[00:23:35] That's, that's the future of this process. It's being able to validate and, and persition oriented treatment protocols for patients based on their epigenetics. Markers and what we can do to change them. And that's it. So it's not just peptides, it's

[00:23:58] Carl Lanore: [00:23:58] everything, but, but it is [00:24:00] peptides. It would give a doctor a better target to use if they're prescribing peptides for a patient who has this and he has that, this patient's data in their hands.

[00:24:10] Well,

[00:24:10] Dr. William Seeds, MD: [00:24:10] absolutely, because peptides are direct signaling agents. As we, as we profess. We think it's the most accurate and most precision, like way to go about in changing aspects of a transcription and phenotype change, so, so, absolutely.

[00:24:28] Carl Lanore: [00:24:28] Okay. Okay. Uh, Danny, do you have any, I know you're, you're not really in the peptide side, right?

[00:24:34] Or are you,

[00:24:35] Dr. Daniel Elías Martín Herranz: [00:24:35] uh, I'm quite a new way to, to this peptide side. I hope dr seats teaches me much more. I'm certainly very interested to learn more about, about this field. Um, I think I would just follow up with why you said say, and you know exactly the same died. We have created a framework that allows people to benchmark on body dating to Vinsons and you know, whether that's a peptide or you know, a [00:25:00] different type of drug or a knife to study intervention or a program that includes, showed up those.

[00:25:05] The good thing about what we do is that it gives you an objective way to ask the question of, did this minus two reduce the biological age of someone? The HSC did risk if this mine to improve them at temple. Listen, if someone it this mine, it's to, uh, um, you know, reduce the impact that certain exposure South when my buddy and you know, I think with that information is, hun, that's really what we need.

[00:25:29] Did Dan go, I'm, you know, percentage wise, these treatments for, for our patients. And that's why we're excited, excited about, about all this.

[00:25:37] Carl Lanore: [00:25:37] Uh, we're going to take a quick, quick commercial break before we go. I want to put the offer up. So we, we told there was 500 people that were eligible from this show.

[00:25:45] I don't know how many have taken advantage of it yet, and I'm sure it's not 500. I'm sure there's more left. Um, if you go to seeds.md/epigenetic hyphen test, epi, G, E, N, E T, I C [00:26:00] dash test, you'll get this for 70, more than 70% off the normal price that people are paying for this vast amount of information.

[00:26:10] Uh, it's $264 U S plus shipping. And so that comes out to just around $314. There was some confusion last show, because we said two 99 and in actuality it was less than two 99, but when you added the shipping in, and then some banks are charging people a fee because mix is in a different country, they're in the UK.

[00:26:32] So there's this, uh, probably this currency transfer rate. A slight of hand that banks do. And so you may end up seeing a $6 charge called a fee or a $10 charge call called a fee. There is nothing that  can do about that. They, they looked into it, they thought there was something that they can do. So in reality, what we ended up doing was lowering the price.

[00:26:54] So it's two 64 plus shipping right now. And, uh, and, and so [00:27:00] everybody should be happy with that price. This is normally $1,040 with shipping. Okay. Just so you understand what you're getting here, this is an opportunity for you to give yourself, your children, the people you care about, a gift, a digital twin of themselves that they can then navigate the rest of their lives.

[00:27:21] Hopefully they are young enough where they have long lives and they can avoid diseases if they're older and they're already suffering from some. The disease States. This could be the difference between them suffering for the rest of their lives or helping them navigate and help their doctor navigate a true remedy to help them.

[00:27:40] This is not slight of hand. This is real medicine and there is nothing better than granola mix out there. There are other epigenetic testing systems out there, a variety of them. Just look at. Blood markers all the way up to, uh, some of them that, uh, that, uh, supposedly, uh, measure 80,000 to [00:28:00] a few hundred thousand points on the DNA.

[00:28:02] This is 20 million, right? 20 million individual data points from your DNA be it's going to be decades before anybody catches up to chronometer and you can take advantage of this. Now I'm telling you something, I'm 61, he's 62 this year. And I'm suffering from some, some things that I probably could have avoided had I had this 10 years ago and now I'm having to do elimination diets.

[00:28:30] Eliminate everything from my diet, eat two or three different foods, see how I feel. Add something back in, and this is, this is like, this is like trying to draw a map by walking blind through the forest and feeling the trees. That's what I'm doing. When when this, this test would give me the map, don't sit and wait for this offer to go and then you'll have to pay $1,000 for it.

[00:28:58] This is not, this is not a buy [00:29:00] a bait and switch. I negotiated this with dr seeds for the audience and this is the deal. So take advantage of it. We're gonna take a quick commercial break. We'll be right back with more. And please post your questions here. If you're watching on Facebook, we'll get them answered.

[00:29:15] Stay tuned.

[00:29:17] Dr. Daniel Elías Martín Herranz: [00:29:17] This

[00:29:17] Carl Lanore: [00:29:17] is the superhuman channel evolution. Just got kicked up a nudge.

[00:29:26] Welcome back. I'm only talking about epigenetic testing, but we're talking about an epigenetic test that will allow you to assess what needs to be done. To change your biological age, because let's be honest, if I am 62 and I'm going to be doing the tests very shortly and I will reveal, I predict I'm a lot, my biological age is a lot older than my chronological age right now, but the data that I [00:30:00] get will set me free because I will understand what needs to be addressed so I can be as strong a youthful as dr seeds.

[00:30:09] So there you go. That's my goal. I look at it. This is exciting to me. This is exciting science. So what do you say, Daniel? There are people out there who are regularly say, I'm trying to choose a diet based on your genetics is in its infancy stages. It's not something that should be trusted yet.

[00:30:34] Dr. Daniel Elías Martín Herranz: [00:30:34] Yeah, so obviously, you know, we can do some things with genetic information.

[00:30:40] Um, and that has been already shown in several studies that allow us to stratify, stratify certain people. Um, by it, obviously it's, you know, we're still in early

[00:30:53] Carl Lanore: [00:30:53] phase. Bill can hear us again. Oh, hold on a second, Danny. Bill.

[00:30:58] Dr. Daniel Elías Martín Herranz: [00:30:58] Okay.

[00:30:59] Dr. William Seeds, MD: [00:30:59] I don't [00:31:00] see, I don't see Danny up there though.

[00:31:01] Carl Lanore: [00:31:01] Oh, well he's there. Don't worry about it.

[00:31:02] He's there. Everybody sees it.

[00:31:06] Dr. Daniel Elías Martín Herranz: [00:31:06] Kind of cured. Dr saves. Go ahead. Um, cool. So, yeah, I was saying that, you know, with genetic information, there's some things to kind of start to be done, um, to stratify people and say, you know, this people are more likely to react to this type of diet. Uh, but the problem is we don't have a way T after the people do the intervention assess.

[00:31:27] If that really worked to reduce this different risk factors, and that's where it be. Genetics is different, right? So we can use that information to make a guess about what's going to work. I'm very informed guests. Uh, but the key thing is that after people have done the intervention or it started with it, we can test again on see if it's working or not.

[00:31:45] And that's really the value of this because, you know, we can try to predict as much as we can and we're getting better and better at it. But in reality, every person is completely different. Um, so first of all, you're going to need, you know, different time points from the same person [00:32:00] to have a proper baseline and a proper controls to see what's working.

[00:32:03] So people are starting to change. And, you know, the way that we have done clinical trials and the way that we have thought about this problem in the past, uh, has been, uh, spoke their receipts before the population level. Right? And that's a problem. And, and we are starting to think about this, uh, what people call N equals one experiments, which means that the experiment is you over time.

[00:32:22] It's not, you know, we're not doing this in groups of people. We're going to start with you and we're going to follow you over time. Measure whether these different things are working or not, and direct you in the right health path. And that's a complete different way to think about the problem that now we can do with, with epigenetic information.

[00:32:39] Carl Lanore: [00:32:39] So, uh, dr seeds is unable to hear or see you, Danny, because we're having some problems. We've been told that we were going to have these problems because of a. The congestion on the internet right now because everybody's home quarantined and just surfing the net. We'll try to fix that after the next commercial break, which I'll take earlier to [00:33:00] have him remedy that.

[00:33:01] Uh, but in the meantime, dr seeds, uh, Danny gave his, uh, his position, uh, on why  is the type of alternative that you can use. To, uh, assay your diet and direct your diet because you can make changes to your diet and go back and test and see what those changes have done. Would you like to, to upon also on these people who say, you know, genetic testing, it's not, it's not far enough along for us to be able to tell, uh, anything about our diet, or maybe they're just talking about 23 and me type genetic testing.

[00:33:34] Dr. William Seeds, MD: [00:33:34] What do you think? Yeah, I think that's just the understanding is that that's a static test. The 23 and a me is just looking at your genome and we're talking about the epigenome, which is where these factors influence what your genome, what it will produce as far as proteins and [00:34:00] enzymes and hormones and ligands and receptors and protease is all the things that your genome does.

[00:34:09] Is affected by the environment, what you eat, stress, um, bacteria, viruses, et cetera. So the genome is set, but we have a things that will influence what, how the genome reacts. And that's the epigenome. So, so absolutely. All of these things can be correlated. And that's the beauty. You can't change the genome.

[00:34:38] But you can change your epigenome. And that's, that's, that's what this is all about. Uh, and, and seeing, being able to see how those, uh, effectively change how a cell functions, that that's the key to what we're trying to put together. And it's, it's like, I like to just put it in a [00:35:00] way of saying, instead of looking at one instrument, you're looking at the whole orchestra.

[00:35:05] Of how things happen and how that, how that beautiful sound comes out or how it doesn't it, and it's not based on one little individual instrument. It's based on the whole orchestra and the conductor and the conductor is basically the epigenome and it's, it's taking all of the, if you look at all those people, they're in the orchestra.

[00:35:29] There are parts of the genome. That are influenced by the way they play their instrument, how well they're feeling that day. You know, all those things influenced that music and the conductor trying to help them through the music. So it really is that type of process. And, and uh, that's what makes us so exciting because it can be changed.

[00:35:51] Carl Lanore: [00:35:51] Dr seeds. Um, could you have your producer disconnect and reconnect you? I think the problem is coming on your end, cause Danny can hear you. [00:36:00] And see you, but you can. So would you, would you try that one more time to disconnect and reconnect and, uh, is your, is your producer there?

[00:36:10] Dr. William Seeds, MD: [00:36:10] Yeah. Yep. One sec.

[00:36:11] Carl Lanore: [00:36:11] Okay.

[00:36:14] I think he's connecting on his, from his phone. We have a couple really great questions and I want to make sure that he can see and hear your responses, uh, because I'm Casey Morrow. Has a son, young, young son who has ADHD. And we know that ADHD has a strong diet, uh, components. We know that, we know that it does.

[00:36:42] And so when we thought looking at diet and this test, obviously this test has the ability to, uh, show how diet influences certain conditions. Uh, dr seeds, can you see Danny now?

[00:36:58] Dr. William Seeds, MD: [00:36:58] I can.

[00:36:58] Dr. Daniel Elías Martín Herranz: [00:36:58] Hey Danny, can you hear [00:37:00] me? It up their seats. I gotcha. Okay. Excellent. All right.

[00:37:03] Carl Lanore: [00:37:03] We have some really great questions and I got to say that I love doing Facebook live because I have the most intelligent audience.

[00:37:11] And have any podcast out there. My, my audience, they're critical thinkers. They don't take anything I say like a gospel where I could tell them, Oh, go out and buy this. And they'll do it. They're so other podcasts who brag about that. But my, my audience, they're, they're intelligent. So Casey Morrow wants to know, would this help figure out how to manage a possible ADHD symptom?

[00:37:32] Cause, uh, because he has a young boy, uh, that he loves. And, and he and Alicia are struggling to find a way to help this child. Wouldn't this test help determine what is wrong with this child's diet right now that could be contributing to these symptoms? Danny, I'll start with you.

[00:37:54] Dr. Daniel Elías Martín Herranz: [00:37:54] Yup. So obviously the first thing that we're going to be able to see is, you know, if this has [00:38:00] somehow affected any of the risk factors that we assess.

[00:38:03] Um, biological age that the metabolic status or the metabolic risk. Uh, how your metabolism is working in general. Um, and then, you know, all the things, for example, that we're developing now also, uh, relate to, to mental health, the, uh, you know, different aspects of diet. Um, so that's, that's a step one, right?

[00:38:24] It's like saying, okay, uh, in this particular case, uh, you know, my, a ADHD, , uh, some of the suspects, and then the next step, you still cause me to go on and try different interventions and see if they work. In that particular case. Um, now I think, you know, there is, uh, more and more evidence as you said, that, you know, their ADHD,  genetic signatures.

[00:38:48] So things to specifically that happen, I'd be able to medic level, um, in, in children or, or people with ADHD. Um, so obviously that's, you know, an area of research that we are also, you know, very [00:39:00] actively looking at and anything that we find. Uh, even if it's, you know, tomorrow, uh, that's one thing that I think makes us different, that we are in constant contact with our users and our clients.

[00:39:13] So if there is anything new that pops up, we send them an email and just tell them, Hey, look, this is what we've seen. You know, I'm, you don't have to wait. Uh, three or four years until, you know, the thing is published and uh, you know, I, you know, there's a lot of people that are fast for this, et cetera.

[00:39:31] You're in continuous contact, very close contact with, with all our scientists. I'm, you know, we're, we will definitely do Casey everything that we can, uh, in that sense.

[00:39:41] Carl Lanore: [00:39:41] Yeah. Cause I think, I'm pretty sure he bought the test for his entire family, him, his wife, and his son. So hopefully this will help them triangulate some possible approaches.

[00:39:52] A Jeff Clifton has the same question in a different way. He says, uh, can this help this test help guide people in regard to mental health? [00:40:00] I want to say something here. There is evidence that a large amount of mental health issues either can have a therapeutic effect from certain diets, uh, or. Can actually be reversed by certain diets.

[00:40:19] Um, so I don't want to go too far here and say, yeah, you know, but the reality is that nutrition plays a large role in how the brain functions. There's plenty of good studies that show that. And so if you do an epigenetic test and it shows you that these things just don't jive with you and your body, then I would imagine that even in some, uh, mental.

[00:40:43] Health cases there, there, there could be some value here. What do you think dr feeds?

[00:40:49] Dr. William Seeds, MD: [00:40:49] Yeah, I think it just relates exactly what to Dan, what Danny just said about the ADHD. A question. It's the same. It's the same issue. Uh, and [00:41:00] um, in particular there's specifically with mental health issues. Uh, a lot of it can be absolutely related to.

[00:41:10] The gut and the immune system and how they work together, uh, but also, uh, secondary to just increasing senescence, um, in the brain, uh, there. So there's lots of issues that can be correlated. And this is where this epigenetic testing is going, because we will get very specific. With being able to look at more and more markers specific to these dates and specific even to age groups in disease States.

[00:41:42] I mean, that, that's how specific it's going to get. Uh, so, so the, the beginning in what we're doing right now to address these issues, uh, are that we can look at epigenetic markers based on nutrition. [00:42:00] Based on age, but also we can look at stress too. That's, that's the next big marker that we're looking at right now in how stress is, how the epigenetic markers are affected with stress.

[00:42:13] So we're getting more, you know, we're getting more finite in, in how we can delineate that. Uh. But that's a, that there's enough information there. Absolutely. For me as a physician to start helping people in all diseases, not just mental health, not just, um, uh, and people that are healthy, that think they're healthy in, in taking them forward and improving their neurocognition and, um, and, and those things.

[00:42:42] So, so it can be really specific, I think, to, to anything.

[00:42:49] Dr. Daniel Elías Martín Herranz: [00:42:49] Yeah, absolutely. I fully agree. I think obviously mental health, you know, it's an area of incredible interest for us. Um, it's something that is incredibly under [00:43:00] studied, uh, for the importance that it plays in our health. Uh, we're currently lacking accurate biomarkers in the context of mental health.

[00:43:08] Um, I cross, you know, many different conditions. Uh, Tony sofas. Studies have shown how, you know, old is different aspects of our life. Lifestyle environment can affect our mental health. Uh, as we mentioned before, and you know, it just like  provides the perfect molecular crossroad to, to study this, right? I took, you said, data today is gonna really allow us to, to build this biomarkers.

[00:43:33] Um, I'm, you know, provide people with accurate measurements. Uh, to see, for example, if, you know, a specific yoga program is working or not, or, you know, a specific, um, meditation program, et cetera, et cetera. So we've been doing these things for each of us and we, you know, we have kind of like different lines of evidence study kind of works by, with this biomarkers.

[00:43:56] Now we can really see if it's working for [00:44:00] you. Right now. That's what makes this so exciting for us.

[00:44:03] Carl Lanore: [00:44:03] Now, this next question may have a, you sharing your screen with us if we, if we can get that to happen, but Patrick Rogers is asking if the results of this Tufts test is simple enough to read, or do you need to have a clinician do it?

[00:44:19] Uh, this test is pretty easy to understand, right? I mean, the results that the. The, the end user gets back. You don't have to go to a doctor and say, what does this say? Right? That's

[00:44:33] Dr. Daniel Elías Martín Herranz: [00:44:33] right. Yeah. We've done a lot of, uh, work on making this understandable by everyone. Uh, so I will try not to then teach you, go and share the screen, uh, and see, we might have to make this work and I'm happy.

[00:44:44] G, uh, Patrick give you a quick view on my actual results. Um, so you can get a taste of my day, what the product looks like on the platform. Uh, the report looks like from insight. Um, so just give me a second. I'll try to [00:45:00] see if this works.

[00:45:00] Carl Lanore: [00:45:00] And if it doesn't,

[00:45:01] Dr. Daniel Elías Martín Herranz: [00:45:01] well, you can tell me and you see my

[00:45:05] Carl Lanore: [00:45:05] know. Here it comes.

[00:45:05] Here comes here, comes. So I'm going to show this right field here. Hold on. And, uh, we're going to go to this type of a view. Perfect. Oh wait, wait. That's even better, right?

[00:45:15] Dr. Daniel Elías Martín Herranz: [00:45:15] Perfect. There you go.

[00:45:16] Carl Lanore: [00:45:16] That's even better. Let me just get rid of this question for a second. So we are actually looking at your screen now.

[00:45:22] Okay. Okay.

[00:45:24] Dr. Daniel Elías Martín Herranz: [00:45:24] So one fantastic. Yeah. So this, these are my results. So this is what they're, what the person, or like what, what you would get Patrick, and, um, you know, I'm happy to give you up week old review, uh, on it. Um, so obviously one of the things that, uh, we look at is at biological age. So this is one of the risk factors that we assess.

[00:45:45] Um, I, and you know, obviously the first thing died. Uh, you will notice this, that very clearly is telling you what your biological age is, right? So this number actually comes from, uh, my DNA sample. Uh, so this is actually what my cells and tissues are telling [00:46:00] me. How old, you know, I'm, I really am. How old are you?

[00:46:03] And next thing that you can view. So

[00:46:05] Carl Lanore: [00:46:05] how old are you?

[00:46:06] Dr. Daniel Elías Martín Herranz: [00:46:06] How old are? So that's time I, uh, chronologically or biologic chronologically. So what. Chronologically, I was 28, uh, when I took this test as well. Okay. So actually my bio took eight much this my chronological age. That's good. Which might be kind of a boring results, but for me, after seeing, you know, oldest threads that I've been going through, uh, I, you know, old active lifestyles that we have tried to, to make this happen, I was sexually, you know, posted differently, sort of priced.

[00:46:37] So for me, this is an accomplishment. Um, but obviously we have people that will have different values right? So we will have people that are younger than expected, that have a biological age, which is lower than their chronological age, and that's socially associated with, you know, a younger profile and vice versa.

[00:46:54] We can also have people that are slightly older than expected. Um, those are the ones that really need to take action [00:47:00] in order to improve this, right? Because they are at a higher risk, uh, from Asians that they should be. Um, you know, there are all the many of things like you can obviously truck your biological age over time.

[00:47:11] What this means is that, you know, as we were mentioning before, this is not only about doing one test, it's about, you know, testing over time and seeing if we might choose, slow down your aging process, uh, as a function of their lifestyle interventions that you're taking. And then there is a lot of information, as we were saying before, to explain this to people, right?

[00:47:30] So we'd like to do it. In a concise manner, but at the same time, uh, you know, giving the key points that people need to get. So, one very important thing on, we, we touched on this before, is that fuck died. You know, if we only do a genetic test. So if we only were looking at the genetic layer of information, uh, which is what many companies do other, uh, in the case of Fijian, you only capture 15% of the entire picture.

[00:47:55] Right? So you were missing up to 85% of variation that comes from [00:48:00] lifestyle, environmental factors. So when we want to find where would be genetics, we'd pick up the anti thing, and that's why, you know, you would never be able to. Two are currently determine their biological, biological age of someone just using genetic data.

[00:48:13] You need to look at the epigenetic layer of information. And this is the case for all the main risk factors off of common diseases, right? So that's why, you know, epigenetics becomes so important because it captures this missing bit that previous tests were not able to, to assess. Um, and we were discussing before as well, the canonical example of epigenetics in humans, which is obviously identical twins.

[00:48:36] So people that have started life with the same genetic material, and yet they can go on, develop complete different diseases and, you know, die a complete different rates on the refugee gnomes change over time as well. Um, so there are also explanations about the technology behind what we do. So all this 20 million epigenetic marks that we assess, uh, using next generation sequencing, you have information about, you know, how your [00:49:00] results compared with the rest of the people from your age.

[00:49:03] And this is very important because the most meaningful comparison, so no one, you know, the Delta. So what are you are at? Uh, it's useful, but it's even more useful to know, Hey, this is better or worse than X percent of the people, because that's going to map you in chief. You know, where you really sit. Um, uh, when compared with, you know, in context for you.

[00:49:23] Um, I know that the thing that we can compare with, for example, is where with the best case scenario, which in the case of human agent. It's actually super centenarian. So people that leave, at least they are 110 years old. And this people not only live really long, but they also live very healthy. They live free of disease, uh, during most of their lives.

[00:49:43] So, you know, we really, you know, you want to look like at the molecular level, like a supercentenarian, um, because that means that you're not only going to spend your life span, but also your health is fun. So you can compare your eight and trajectory right now. I've to measure, you've seen your, your [00:50:00] DNA methylation, your epigenetic profile.

[00:50:01] We've got typical trajectory that someone that will go on and become a supercentenarian will typically have. Um, so that's again, you know, it gives you a taste of how far away you are from the best cases scenario in the case of human agent. Uh, and you know, what you need to do. Uh, it's obviously the next step, right?

[00:50:20] So where are we excited about this? As we were saying before, uh, what we can do is die. The facto, what we can build is, uh, those response curves for lifestyle factors. And let me go and explain this in more details. So what this means is died. You know, in the same way that we can, you can go to a doctor and he will tell you, Hey, take a hundred milligrams.

[00:50:41] So far, I said to Mo, and this will have this effect in your body. Um, now we can do the same with a specific lifestyle and pharmacological interventions and the impact that that will have on your epigenetics, uh, on more specifically in this case, on your bottle to bleach. And we can do this against [00:51:00] all the data that we have from you.

[00:51:01] So what this means is diet in a data driven and personalized way, we PR we can prioritize for you. Why are the main things that you need to do right now? This things will be obviously in categories of things that we know are important. It will be related to exercise, it would be related to diet, it would be related to certain supplements to asleep.

[00:51:22] But the key thing, and you know what we can do and no one else can do, is the fact that because we also have your epigenetic information on your biological age, we can objectively prioritize this for you and tell you if you're only going to do one. This is the one that you want to focus on, uh, because this is the one that's most likely to work for you.

[00:51:41] And this is the amount by which you need to change it. Right? And that's what that'd be. Genetics cannot that previously, uh, we didn't have, so in my case, um, you know, the main recommendation that I get, and I did take action on this because when I saw this, I was like, wow, you know, there's so much opportunity here, there's a [00:52:00] win.

[00:52:00] Um. It's actually like increasing vigorous exercise, which, uh, for those of you that are familiar with this, it's actually, you know, doing, uh, certain types of fixes, size that increase your heart rates are both 75% of this maximum. And ideally, uh, with, uh, this what is known as high interval training. So, you know, you do, you do, for example, I sprint during one minute where you raise your high rates, uh, beyond the 75%, and then you recover for a bed and then you do it again.

[00:52:30] If you do that. In my case, that's the biggest thing that I can have one of my bottle chickadees right

[00:52:35] Carl Lanore: [00:52:35] now. This is so exciting.

[00:52:38] Dr. Daniel Elías Martín Herranz: [00:52:38] I'm so obviously, you know, there are other

[00:52:39] Carl Lanore: [00:52:39] aspects. And you could see that this is very easy. Uh, getting back to Patrick Rogers question, this is very easy to, to read it. It gives you specific paragraphs, directives.

[00:52:52] It explains itself. You don't have to go to a doctor to interpret this. Now, Jeff Clifton asked an interesting question, and that [00:53:00] is what if you did take this to a functional medicine doctor. Uh, are there any chances that they would know what to prescribe or how to use this data to give you better results with your life?

[00:53:13] What do you think doctor dr seeds?

[00:53:17] Dr. William Seeds, MD: [00:53:17] Absolutely they would love this information. This, this is information that will only make that relationship even better. So, so this is what this is, what's beautiful about this is this can be directly consumer driven. And, but it's also, from my standpoint, with my patients, I'm utilizing this with my patients.

[00:53:36] So, so we're, we're in two different areas. Working to gather to accomplish the same thing. Can it help me more to help you? I think so. I think I can do a lot more, but there, but your audience, you've got a lot of very smart people. You've got a lot of people that like to, you know, that are, that are very adapt to understanding.

[00:53:58] How the literature's [00:54:00] changing with, uh, with exercise and nutrition and supplements and so, so they can vary this themselves also. But this is, this is the beauty of this approach. It helps everybody.

[00:54:13] Carl Lanore: [00:54:13] Well, but the other, the other side of that, the other side of that is the, sorry, I didn't mean to talk over you.

[00:54:19] The other side of that is if this was something that was only sold through doctor's offices, then you'd have this additional layer. Uh, of, of profit that has to be built in because doctors don't do things for free. The idea that you can go direct to the company and buy this, uh, because that type of a business model direct to the consumer is, is really the ideal way for a company to drive sales.

[00:54:47] That ended up being more cost effective for the end user. Because if this was a two step where you sold it to the doctor and then the doctor sold it to the patient, just by virtue of the fact that we know that that relationship [00:55:00] exists, we know that there has to be an extra layer of money in there, whether it's a dollar or $100, you're paying extra for it and you avoid paying extra for it.

[00:55:10] When you go right to the company and buy it isn't, I mean that, that's logical, isn't it? Danny.

[00:55:19] Dr. Daniel Elías Martín Herranz: [00:55:19] Oh yeah, yeah, absolutely. I mean, obviously, you know, I'm not probably the right person to speak about when it comes to like pricing, uh, business models, et cetera. Uh, my role is more around, around the science, on the products, um, by, I will be happy to, you know, find more information about that if, if that were useful.

[00:55:39] But obviously. Uh, you know, at the end of the day, what we want to do, uh, I'd, Cornell makes is to make this available to everyone. Like our goal is that every single human being in the world can benefit from this independently of. Any other variable, right? So we want to, you [00:56:00] know, engage everyone and improve the health of every single human being on, on a stand.

[00:56:05] Health is fun radio, planetary scale. So that's the ambition behind corn Omex and you know, we're not going to allow anything to, to stop by seeing that endeavor.

[00:56:15] Carl Lanore: [00:56:15] How frequently would someone want to test? Once a year? How long does it take to start to see the early signs of the. Uh, therapeutic approaches that you're, you're an  listing to actually take effect, Danny.

[00:56:33] Dr. Daniel Elías Martín Herranz: [00:56:33] Yeah. So obviously. It depends on the specific thing that we're looking at. So the good thing about it, but genetics has studied, captures a temporal dynamics. I've many different layers, right? So there are certain epigenetic marks that will change, even necessarily Kadian monitor. So, you know, even the not, you know, 24 hour cycle depending on how your body is reacting to different times of the day, but [00:57:00] they are things that are important for our medium and long term risk of disease, uh, saints more in the order of, um, more towards years.

[00:57:09] Right. So if you're interested in something like biological age, um, typically. Glee. I mean, obviously there are, you know, um, exceptions to this and every person would be different. But if we use a rule of thumb, um, the typical, like really a strong, meaningful changes, we see them between six months to one year.

[00:57:29] Uh, but in the case of, for example, metabolic status, which is what I have right in front of me, which is really assessing, uh, your metabolic risk. So the risk of having a . I'd be regulated metabolism that can affect things like your risk of tattoo, diabetes, mentally, what it seems from a cardiovascular disease, et cetera.

[00:57:47] Uh, this obviously changed this cluster. Uh, so we see changes. See if any of, you know, I'm, I'm very strong, meaningful changes seen in three months, two to six months, right. I'm, I'm, we have. Uh, for example, we're working with [00:58:00] clinics that have, you know, super strong weight loss programs, uh, that might extreme proof this, uh, in that period of time.

[00:58:06] So it really depends on what we're talking about, um, that the biomarker or, or the risk that we're looking at, um, how BBA to the person is from, from the best case scenario. So what's the potential to gain? Um, I know, so on how that individual person that sticks to the intervention on, on response to it. Uh, but as a rule of thumb, uh, where we commend that people test, um, every three months if they are looking at metabolic status on every six months to one year, if they are lifting at biological

[00:58:36] Carl Lanore: [00:58:36] age DACA seed, you want to contribute something to that?

[00:58:39] And then we'll answer Natalie Fisher's question.

[00:58:44] Dr. William Seeds, MD: [00:58:44] Yeah. I, I, I agree 100% with, uh, with the metabolic aspect, it's, it's every three months is kind of a intervals that w that we would. We would expect to see some change in, in the therapies of either nutrition or exercise or, or [00:59:00] supplements or, uh, or anything like that.

[00:59:03] Um, also with just with exercise changes, you're gonna see, like with Danny's talking about high intensity type of changes, you're going to definitely see that in three months. Um, so those are kind of nice guidelines. A three month guideline is really nice for those type of aspects. Uh, if you're looking at, uh, looking at toxins and things like that, which is another aspect of their testing that might be more like a six month type of interval, and then, you know, the aging can be once a year or every six months.

[00:59:34] Again, it's really, it's a real, the, the beauty of this is, um, it is. Uh, it's a choice that you can make depending on really what you're trying to change. And I think, again, that's, that's the real critical point of this is that it's a constantly changing dynamic, uh, based on what you're looking at and how you're trying to treat it.

[01:00:00] [01:00:00] Carl Lanore: [01:00:00] So, uh, Natalie, we actually talked about autoimmunity early on. That was something that was of interest to me. And yes, this test can help pinpoint. Uh, some of the things that may be contributing to or causing, uh, your autoimmunity. And I think the last discussion about frequency of testing, I would believe, and I'll, and I'll defer to the scientists here, but autoimmunity would fall into, I think, biological, uh, metabolic, uh, framework.

[01:00:29] And I would say that you probably would see signs that your, uh, autoimmunity is getting better. Uh, test wise, within three months. Would you guys concur? Would you agree with that?

[01:00:44] Dr. Daniel Elías Martín Herranz: [01:00:44] Yeah. So every, obviously one person would be completely different. Um, so it's always risky to make predictions without seeing that data. Uh, um, we have seen, you know, for example, something like chronic inflammation, uh, kinda affects the biological age [01:01:00] indicator. So one of the things that is really exciting about, you know, vital escalation is that it's speaking up, um, effects from how our immune system becomes the regulated.

[01:01:10] As we age, right on. One aspect of feds is that it is not as effective in fighting infections anymore. And we see this now clearly with, with Colby 19, uh, with seeing how, you know, how different the risk is for someone that is sold there, when compared with someone that is younger. But then the other aspect that maybe not so many people are familiar with is something known as inflammation, which is the fact that we've developed much more inflammation and chronic inflammation.

[01:01:38] That has been, you know, described us one of the courses behind several of the CSUs old Zelas, we H. um, so, you know, obviously you will depend on a person to person basis. It's difficult to guess without seeing the data. Um, but I think, you know, something like biological age could be useful in that particular

[01:01:56] Carl Lanore: [01:01:56] case.

[01:01:58] And I just want to put this up for people who are [01:02:00] showing up late to this discussion. You can go back and listen to the entire interview, uh, after the show was over. If you go to seeds, that MD slash epigenetic hyphen test, you'll get this thousand dollar test. This is what they sell it for all over Europe.

[01:02:16] For $264 us has only 500 of these available at this price for my audience only. You will not find this test anywhere else in America, but here at superhuman radio, if you go to their website blind, you'll see that they charge $1,000 for this test. And so this is an outstanding opportunity for people to literally create their digital twin as a doctor.

[01:02:41] Her Ron's likes to call it. I love that. So that you can see. Not only how you are aging now, but what you need to do. To correct the things that are not working well for you, because the test is very easy to read and gives you specific directives. Uh, you know, you can stop [01:03:00] guessing, you know, uh, in the case of a, a Natalie, I have an autoimmune disease.

[01:03:05] I, I've said it, you know, I've talked about it on the show. Uh, it's a very, very scary one. My sister died from it because they mistreated her as having Parkinson's disease, but I see the direct results. Of dietary interventions with it getting worse and getting better. But it's like I said earlier, it's like I'm going through the forest trying to create a map with my eyes closed, feeling the trees.

[01:03:30] I can't do that. I'll take too many missteps. This will give me the map. This will show me what I need to get rid of to reduce the, uh, inappropriate inflammatory response that's causing the nerves in my hands and legs and face. To deteriorate. And so I am so excited about this and I'm excited for everybody in the audience too.

[01:03:54] This is not a sales pitch, folks. You know, if we were selling it for a thousand it would be a [01:04:00] sales pitch. This is an opportunity for you and your loved ones to create that digital twin and take it through your life and see what you're doing, how it's affecting you, and how to change it. This is very exciting to me.

[01:04:15] 20 million data points of your genome are evaluated in this study and in this lab lab, nobody does that. The most I've heard out there is 800,000. Nobody does that. This is next generation sequencing. It's not available anywhere else. This is a fantastic opportunity to take advantage of it. Uh, we're going to answer a couple more quite well, let, let me do this.

[01:04:38] Let me take all last commercial break and we have like one or two more questions that we'll get to. Uh, you're listening to super human radio. Share the show with your friends. It's a gift. Share this show. You're giving them a gift. We'll be right back.

[01:04:53] Dr. Daniel Elías Martín Herranz: [01:04:53] Superhuman channel

[01:04:54] Carl Lanore: [01:04:54] where we use oxygen for the power of good.

[01:05:00] [01:04:59] Hopefully dr seeds could still see and hear Danny. Oh yeah. He's disconnecting and reconnecting. Every time we, uh, we go to commercial break, I think he loses his audio. That's okay. We'll plug the, the a website again. Seeds, MD. Slash epigenetic hyphen test, and we'll get dr seeds back in here. Hold on a second.

[01:05:24] There we go. There we go. Okay. And voila. Voila. Okay, so let's get rid of that. We got a couple more questions and then we'll wrap it up. Um. So Jeff Clifton wants to know, and this is really a good question, and I'll tell you why. Cause I'm a, I'm getting ready to do some groundbreaking shows on the effects of EMF and RF on tissue.

[01:05:49] Because with the onset of, uh, or the, the, the introduction of 5g, which true, right now they are introducing low 5g, which is six gigs. But when they introduce true 5g [01:06:00] here in the United States, which is 24 to 60 gigahertz, we're going to see a host of new problems. Uh, manifest in our population, I'm sure of it because we already have good research from Scandinavia, from, from Egypt, from Iran, from China, from all over the country, uh, over the world except the United States showing that even the current 4g disrupts the microbiota, can caused a rhythm, changes in the heart, may be linked to, uh, uh, idiopathic mitral valve prolapse, which is rampant in our population today.

[01:06:32] And the list goes on and on. What about EMF? Is there any way, could we talk about toxins and and, and, and things like that? Is there any way to assess the effects of EMF and RF on the genome? Who wants to take that? Dr seeds is shaking.

[01:06:50] Dr. Daniel Elías Martín Herranz: [01:06:50] I can,

[01:06:53] Carl Lanore: [01:06:53] what do you think? What do you think.

[01:06:57] Dr. William Seeds, MD: [01:06:57] Absolutely. Because those are stressors.

[01:06:59] Those [01:07:00] are stressors to the, to the, to the genome. And, uh, there, there are absolutely going to be methylation changes that are specific to what's happening, um, from that, from, from that type of a stressor to the cell. So there's no doubt that there are going to be changes that can be mapped out specific to that, Danny.

[01:07:21] Correct.

[01:07:23] Dr. Daniel Elías Martín Herranz: [01:07:23] Yeah. So obviously the good thing about, about this is diet, as you said, different stressors can, you know, cost. Uh, it'd be 10 exchanges. Um, I must admit, I'm not particularly familiar with, with the effects of EMF on, on epigenetics yet, but it's a great question. So I will look it up, uh, from now on.

[01:07:43] Um, so obviously very something that would reflect on. On the biomarkers, right? So we will pick it up. Um, and that's really the video fit, that it's, it's agnostic to a certain extent to this stressor where it comes from, right? So different, different [01:08:00] sources of a stressor as kind of collapsed in the same pathway so many times that, you know, could be, for example, with, uh, with the way that DNA dynamics can be repaired, uh, to an example.

[01:08:10] Um, so you know, if there was sin, if you've been exposed. And there's  on effects on your health, uh, we will likely to get out. Um, so that's, that's the beauty about epigenetic things as well. I'm, I'm obviously, you know, as we, as we gather more and more information and, uh, you know, we, uh, as we collect data from, from exposures, from, you know, different stressors, uh, we will be able to assess over time more and more precisely.

[01:08:37] You know, which one is likely the one, uh, costing it. Uh, but I think at the time being that the key thing is that. You know, it has an effect on your bottles. We'll dig it out.

[01:08:47] Carl Lanore: [01:08:47] So Casey Marlow has a good question too. For those of us who want to test a few times a year, maybe a couple times a year, do we, do we pay the same fee for that test or is that included in [01:09:00] our first year subscription?

[01:09:02] Dr. Daniel Elías Martín Herranz: [01:09:02] Yeah. So again, probably note that the best person to ask this question. Um, but from what I can, uh, tell right now, um, obviously you'd be Benz Casey on, on the, you know, the, if you bought it through here, I'm assuming that it's, you know, it was for one test, um, say if you would like to retest. Uh, you would need to buy a new one.

[01:09:23] Uh, but I think it's probably better if you just write to us. Um, you know, in, in, you're gonna get a right to me. I've done the entrepreneur mix, good column where I didn't quite what I'm used to calling. And we will be able to, to help you out, uh, with, with this question more precisely.

[01:09:39] Carl Lanore: [01:09:39] And then the last question from a Jeff Clifton, and this is a good, good question that we've over w kinda overshot it.

[01:09:46] He said, who are the people and what are their backgrounds that are doing the calculation and these results, the who's behind granola mix that we should be impressed with that say, Oh, you know what? These people really [01:10:00] know what they're talking about.

[01:10:06] Dr. Daniel Elías Martín Herranz: [01:10:06] Well, one of them is me, but obviously there are many more people. I'm, uh, you know, I think one of the things that we can be really hoppy about, it's this super team that we have, like proteomics. Uh, both from, you know, a scientific side of things. And also, you know, from my commercial side of things and from my educational, uh, side of things, um, so scientifically, uh, our origins go back to the university of Cambridge in the UK.

[01:10:30] Um, so three now where PhDs. Uh, both myself, I'm on. Dr. Thomas stops, who's the CEO on, on co-founder economics. Uh, we were doing PhD's on VOP genetics of agent. Uh, so we've spent for more than four years. So far. We're lives is dedicated to this field and, you know, really understanding, uh, how we can use epigenetics, genetics to quantify aging very accurately, humans.

[01:10:54] And also, you know, the recipes. Um, and then, you know, other members of the team, [01:11:00] um, also have, you know, like dr Toby Cole, uh, who has also a fantastic, uh, scientific background in biotechnology as well. Also in Cambridge. Uh, we also have, um, you know, Taos school who, you know. Uh, and, and you probably go through since you know him.

[01:11:17] So he sent all the rope they fall, and there's, and you know, he's, first of all, a contested human being, but also, uh, you know, I've great, great commercial machine. Uh, I'm, you know, our CTO Rob Thompson, now we have on Jordan. I mean, I will need to keep going on, but, uh, you know, we have a fantastic team both at the scientific level.

[01:11:38] Um, and, uh, you know, the commercial I'm support and technology. Uh, level. Um, but yeah, I think the key thing is that the science, you know, that that drives 

[01:11:52] Carl Lanore: [01:11:52] genetics

[01:11:53] Dr. Daniel Elías Martín Herranz: [01:11:53] and you only need to do get as well. Oh, our scientific advisory board on C, you know, [01:12:00] who's behind us. Um, I'm, I think you can seek that out in the website.

[01:12:04] I'm on, you know, weed about those people. Uh, but yeah, I think that's hooked that, hopefully that helps.

[01:12:11] Carl Lanore: [01:12:11] I think it does.

[01:12:14] Dr. William Seeds, MD: [01:12:14] Well, and I'll, I'll just add to it. I mean, I've been actively researching this for the last two years since we knew, since the beginning of where, uh, we knew this, uh, or bath paper was coming out on biological aging.

[01:12:31] And I've been in search of looking for who has the best platform and algorithms and information. And. Scientific backing behind them to validate what they've done. And I mean, I've looked at everything, so this is why I'm here. Um, this is what I'm utilizing for my patients. So I think that says a lot right there

[01:12:57] Carl Lanore: [01:12:57] on that.

[01:12:57] On that note, dr seeds, tell, tell us, [01:13:00] give us some, some, tell us a story about some of your patients and how, uh, this testing has helped you triangulate the outcome. Because, you know, we now know that osteoarthritis. Is, uh, an autoimmune disorder. Uh, not, you know, previously it was thought to be, uh, the wearing and tearing of mechanical loading.

[01:13:20] But we know that obese people have degeneration in their cervical spine, and it's not because their heads are too heavy. And so we know it's an inflammatory in nature. We know that it seems to be, uh, somewhat, uh, autoimmune in nature. Have you been able to successfully use this test. To help specific patients without giving us their names.

[01:13:40] Kind of give us some stories. Uh,

[01:13:44] Dr. William Seeds, MD: [01:13:44] no. So I have not, so two, two points there. The auto immune part is so, so your, your, your statement about autoimmune disease and osteoarthritis is, [01:14:00] is interesting because. Actually, we're finding that auto, the immune system has everything to do with about every disease process, right?

[01:14:08] And you bring up, are you really, you, you bring up a really great point because of how the intricacies of the immune system really are validated in every disease we know, including cancer and aging. So, so that, that aspect is becoming even more prevalent in, uh, and understanding that. How more important this epigenetic testing can be.

[01:14:35] Um, so I'm in the, I'm in the beginning right now of just utilizing this type of information. And it actually, I'm on the science level, like Danny, of where I'm working with, with  and where we're looking and validating therapeutic processes of using certain supplements of using certain peptides of use, utilizing nutrition.

[01:14:56] I mean. We've got this vast array of studies that we want to do, and [01:15:00] it's just picking the book where, you know, w w starting with the smaller ones to validate and validate and validate. So I'm really big on the research part of this. Um, and as far as starting off with utilizing this information for patients, I haven't gotten to the second stage of where I can show that there are changes because I'm not that far along, but I'm, I'm, they're initiating that process.

[01:15:24] Um, and. Well, you know, I, I want to be able to validate this to the world that this is exactly why every one of us should be involved in this. And that's, that's my job in moving forward is the, uh, on the science and clinical side, the translational side of this, of bringing this to the forefront too, to provide that platform that valid the dates without a doubt.

[01:15:51] Everything that we know scientifically. That it translates into, uh, into treating people medically. Yeah.

[01:15:58] Carl Lanore: [01:15:58] I, I would call this [01:16:00] optimistic medicine.

[01:16:00] Dr. Daniel Elías Martín Herranz: [01:16:00] Absolutely. And you know, we're really excited to, to, to work on

[01:16:04] Carl Lanore: [01:16:04] this. No, go ahead. I'm sorry.

[01:16:07] Dr. Daniel Elías Martín Herranz: [01:16:07] Yeah, I was saying that we're super excited at Chromebooks as well. Dr seat's D yeah.

[01:16:12] To, to do this, this things with you. Um, you know, it's incredible times that we're living through, um. And we are, you know, for the first time in history, leading, maximizing and utilizing this type of data, uh, to help people. Um, and, you know, hopefully we discussed already, you're in the podcast, epigenetic data size, you know, you're not preview, let's place to do this.

[01:16:34] Uh, and for the first time be able to robust antibody. They have many, many of this interfaces. So we really look forward to, to work on this with you.

[01:16:44] Carl Lanore: [01:16:44] I think this is a. Optimistic medicine. And what I mean by that is today medicine is pessimistic, right? You go to the doctor once you're sick, and then the doctor gives you your prognosis, and very, very rarely does the doctor say, [01:17:00] Oh, I can fix this.

[01:17:01] No, the doctor says, well, you'll have to take this drug and probably for the rest of your life to make up for what broken in you. And that's pessimistic medicine that reminds us we're getting older.  excuse me. It reminds us that. We're breaking down. To me, this is optimistic medicine, and I say that because I'm thinking about the hopefulness I have right now to get tested so that I can see what I'm doing wrong and what areas I need to improve upon and take that directive.

[01:17:36] And that instills me with hope and optimism is hope. Energized, and so this is, I love this. This is this. I'm so excited about this. I mean, it could actually make me meal emotional because I think of all the people that are suffering with diseases, who would do anything, anything to change it, they would stop [01:18:00] eating their favorite foods.

[01:18:01] They would stop doing , but they don't know what to change. And this gives them hope. This is so exciting. This is exciting. I want to thank you guys for being on today. I want

[01:18:14] Dr. Daniel Elías Martín Herranz: [01:18:14] to back them. Completely agree.

[01:18:16] Carl Lanore: [01:18:16] Thank you for the generous offer to my audience. This is not a sales pitch, folks. This product is $1,000 if you don't believe me, go to the chronometer website.

[01:18:27] See for yourself. They sell them all day long for that price, no problem. Because executives and high level people who could drop $1,000, they want to know this because they want to have a lifespan and health span that goes hand in hand. Those of us who can afford to just drop $1,000 here and there, this is our opportunity to take advantage of his science.

[01:18:51] That was previously out of reach for most of us. Seeds.md/epigenetic [01:19:00] epi, G, E, N, E, T, I C hyphen test. You'll pay $264 U S plus shipping. There may be some nonsensical charge for $6 or $8 by your bank because of this is UK. You're doing business with. So they always try to, you know, this is an arbitrage where, you know, the value of one currency against the other currency.

[01:19:25] Don't be upset. This is not from chronometer. They tried to figure out where it was coming from and it varies by your bank. Some banks aren't charging it at all. Just for the record, I think if your credit card you use has no international fees when you travel, you probably won't get charged that, that fee.

[01:19:42] But, um. The this. This is a test that everybody should have. And if you have young children, give them a gift. Now long after you're gone, they're going to go back and think, mom and dad was so frigging smart to get this for me because [01:20:00] I have navigated so many illnesses that I would've walked right into had I not had this information.

[01:20:06] This is a time capsule. It's a time capsule. It's your digital twin. And you can, you can look at what you're doing and look at your digital twin and go, Oh, I'm not doing the right thing, so don't waste any more time. You're smiling, bill. Why? Why are you smiling?

[01:20:24] Dr. William Seeds, MD: [01:20:24] Because Danny and I have talked about this many times.

[01:20:26] I keep telling Danny, go, Danny, you're going to be famous for digital twin, right? He's not taking, he's not biting on that.

[01:20:33] Carl Lanore: [01:20:33] You know? No, I like it.

[01:20:36] Dr. Daniel Elías Martín Herranz: [01:20:36] It's been works and people locally are terrible. I'm, yeah, I'm happy to go with it.

[01:20:42] Carl Lanore: [01:20:42] Peanut PANORG is a friend through the show. They're all free. All my listeners are friends of mine that I feel that way.

[01:20:49] He came late. He'll have to listen later. Uh, yes. It's a great show. You've got to listen. Of course. Uh, uh, Natalie Fisher said, thank you so much. Uh, Casey, Alicia, uh, Casey Morrow said, thank you guys, uh, [01:21:00] really passed this around to people you love. Pass this show around to people that you care about. You care about their outcome because, and they can do this themselves.

[01:21:11] They don't have to go to a doctor and do it. They don't have to be involved with a physician. They can order it themselves and, and take care of it. Hi, Sarah Bowers. How are you? Nice to see you. She helped me sell my mom's house when my mom passed away. Uh, and you need to listen to John needs to listen to this show.

[01:21:30] Sarah. John needs to listen to this show. I just thought of it. Please have him listen to this show. You guys need to take advantage of this. All right. That's it. I could go on and on. A pleading for those of you to take steps to care for yourself. Uh, but you have to do that yourself. Thanks guys. Thanks for being here, Danny.

[01:21:48] Thanks for being here, dr seeds.

[01:21:51] Dr. William Seeds, MD: [01:21:51] My pleasure.

[01:21:53] Dr. Daniel Elías Martín Herranz: [01:21:53] Thanks for having me.

[01:21:54] Carl Lanore: [01:21:54] Take care of. We're gonna say goodbye. We've got plenty of good shows this week. Tune in. We'll see you then. [01:22:00] .