Show Notes:

[2:59] Joel’s book covers topics that are just emerging.

• Most books do not take into account how things happen in the body.
• There is a what, when, and how to everything.

[4:41} Metformin: Joel’s position.

• It is a matter of how it works.
• It increases core protein density in the mitochondria.
• It works by increasing the pourocity of the mitochondria.
• This can allow more substrate to flwo through the mitochondria.
• This could actually be a bad thing.
• We do not 100% understand how the mitochondria works.
• Metformin/ berberine can be wonder substances, but they should not be used all of the time.

[9:01} Biological duality.

• Anything can be good or bad depending on context.
• We have to get out of the black and white viewpoints of health.

[11:47] How to use metformin/ berberine.

• Everything it affects occurs during sleep and are enhnaced during sleep.
• Sleep needs to be restored first.
• Periodic stimulation with metofrmin should always be coupled with periods of growth.
• This type of approach could possibly be used during a famine phase of training in order to enhance anabolism during a feast phase.

[17:07] Napping after fasted training.

• Energy intake cannot be separated from growth.
• Activation of starvation cells prime muscle growth.

[19:33] Can meditation replace napping?

• No, but it does have its own benefits.

[20:25} GLP-1 vs metformin.

• Splitting hairs at some point.
• There are different mechanisms provided from both.
• Incretin sensitization: Joel recommends food.

[22:15] veepnutrition.com/book

[28:10] The problem of how humans really eat.

• Shrinking of fat cells is a survival mechanism.
• We were meant to get though prases of starvation first.
• Survival will make you eat.

[31:55] The fed state (5-7 meals per day).

• Do these small meals have can advantage?
• Different days of the week require different nutrition.
• There are unique protein the make you leaner that circulate the blood after feasts.

[32:23] Anyway to predict the nutritional timing requirements?

• There is a best day of the week for sodium, regardless of intake.
• Heart attacks occur most on mondays and thursdays.

[39:37] The “Hulk” effect.

• Longer Ampk activation amplifies a susequent MAPK and MToR activation.

[42:17] time restricted feeding.

• Much of the research was done in the obese and in mice.

[46:55] TRT for SIBO?

• SIBO affects the mouth to the rectum.
• Issues in the gumline can cause trouble in the gut.

[59:47] Neurological disasters and the gut.

• Inflammation, not telomerase aging, is the primary driver of aging.
• There are limits to what you can do by fixing the gut.

[1:03:00] young fat vs. Old fat.

• Once macrophage signals infiltrate fat cells, they can take an immunological configuration.
• The fat system can take on multiple configurations.
• Old fat: M@ macrophages downloads its inflammatory state throughout the body.
• It does not burn as well and stores as visceral fat.

[1:08:38] Felling worse even though you are getting better on paper.

• With Sibo, it is almost like a local injury.
• Xifaxin can help fix it.

[1:12:32] Fiber overload.

• Fiber is essential for butyrate production, but too much can injure the gut.
• When there is gut injury, the lining must be restored before it can convert fiber to butyrate.
• Bathing the gut in ascorbic acid and fasting can help clean up injury.

[1:16:17] the gut and thyroid.

• It is a matter of the gut going first.