Ronnie Milo
In light of new guidelines suggested by the American College of Physicians released on Monday, older men should not be prescribed testosterone except to remedy sexual dysfunction. Are they completely wrong? A recent study in the Journal of Cardiovascular Translational Research looked at Testosterone levels and the association with the main risks for CVD, namely metabolic syndrome, type 2 diabetes mellitus, obesity, atherosclerosis, dyslipidaemia and hypertension. Is the new guidelines putting more men at risk?
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Show Notes:
[3:06] Vascular pathways of testosterone.
- 2019 study.
- There was a correlation between low T and cardiovascular disease.
- CVD does not occur in and of itself. It is a down-the-road symptom of metabolic disorder.
- Total test of the low test group: 8-48 ng/dl.
- TRT 100mg/week showed improved markers of CVD and mitigated CVD via vasodilation and vasorelaxation.
- The heart actually has to work in order to relax the blood vessels.
[14:25] Nitric oxide boosters.
- Testosterone seems to have one of the most appropriate N.O. boosting properties.
[22:08] Older men should only be given TRT to treat sexual disfunction?
- S.
- Test cannot be the only culprit. This is evident in all pubescent males that do not have prostate cancer.
[32:56] There are psychological effects from androgens.
- This can be good or bad in the case of underlying disorders.
[40:21] Stroke is a 2 component occurrence.
- Red blood cell count is a measure of viscosity, not necessarily stroke risk.
- MCH and MCHC is a better marker for blood clotting.
- These are also liver damage markers.
[43:16] Cancer.
- 2008 show: Test was not correlated with prostate cancer.
- SHBG was.
