Joel Greene

Gabriel Shaw sent a question as a result of Joel's last interview. Joel said the three distinct points in which the body ages is early 30’s, early 60’s, late 70’s. Why is that? And what can we do to avoid these unwanted changes? PLUS What I'm Digging.. recent blood work scared the crap out of me.. here's why.

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SHR # 2461 :: Proteins In The Blood & Aging PLUS What I'm Digging..

Show Notes:

[6:55] New study: Plasma proteome was analyzed

• The data suggested 3 distinct aging periods.
• 34, 60, and 78.
• 34- matrix melanoprotease 12.
• Deals with how well the body can snap back from changes in fat mass.

[13:24] Remodeling the extra cellular matrix is energy intensive.

• Repeated remodeling can form cancer adjacent adipocytes (substrate for cancer cells).
• Cancer cells and fat cells are the only tissues that can expand their size indefinitely.

[16:35] The cumulative variables that drive this phenomenon.

• Collagen 6 plays a role in stiffening old fat.
• Every time that you lose fat and gain it back, you are aging.

[25:40] ADP ribosylation reaction.

• Involved in energy production and requires NAD+
• Inflammation and senescence should be spun down and taken care of before using NAD+ supplementation in your 30’s.
• Over abundance of NAD+ serves as a substrate for inflammatory macrophages.

[41:30] The endoplasmic reticulum.

• It is the “3D printer” of the cell.

[46:00] The immune system’s role in aging.

• Measures of serum glycans are better indicators of aging than telomer length.

[51:20] Accumulation of metabolic waste.

[55:05] Secratory senescence.

• Drop in HCG levels in your 60’s.

[1:00:20] Resistance training reduces senescent cells.

• As muscle ages, it accrues intra muscular lipid drops that cause a feedback loop in muscle.

[1:04:48] Methylation and aging.

• A valid point of view, but serum glycans are, perhaps, a better model of aging.
• Remaining active and preserving muscle is still ideal in your 60’s.

[1:18:00] How do low protein diets influence the early onset of aging.

• Methionine restriction can extend life, but it also reduces the qulatiy of life.
• Vegan diets lower brain function in the long-term.

[1:23:26] Mechanistic differences in animal and plant fats.

• Animal fats can be shuttled into the brain more efficiently.
• Mtor helps the brain to repair itself.

[1:24:25] What to do in your 70’s.

• GDF-15 mediates inflammatory signals. It is increased as we age.
• Centinarians have inflammaging in a way that hormetically benefits them.
• Macrophages can be steered to inflammatory or anti-inflammatory states.
• There is an order of operation when it comes to addressing the macrophage of each tissue.

[1:37:33] Carl’s bloodwork.

• Pro-BNP and micro albumin were increased.
• These numbers can be elevated due to training.
• The athletic phenotype should be considered by the medical orthodoxy.

Show Transcript SHR # 2461 :: Proteins In The Blood & Aging PLUS What I'm Digging..