Dr Sylvia. Christakos - Jared Ward

A Rutgers study has discovered that vitamin D regulates calcium in a section of the intestine that previously was thought not to have played a key role. The findings have important implications on how bowel disease, including ulcerative colitis and Crohn's disease, may disrupt calcium regulation. PLUS This may be the greatest, most convenient tool to aid in recovery and injury management ever to be invented.Learn more and save 15% off the Myostorm Meteor at https://shrnetwork.biz/meteor and code shr15 .

The syudy discussed on today's show
https://www.sciencedaily.com/releases/2020/12/201201171732.htm

[3:47] why study vitamin D regulation in the intestine?

• It was previously thought that only the proximal intestine played a role.

[5:10] Study design.

• Mouse model: genetically engineered to have no vitamin D receptors anywhere except in the colon.
• Those receptors alone reversed Rickett’s vs. complete VDR knockout mice.

[7:53] does this concern just oral vitamin D or also photo-generated vitamin D?

[11:18] Are subclinical bowel issue sufferers at risk of vitamin D malabsorption?

[15:25] How long did it take vitamin D to reverse the effects?

• The measurements were taken at 8 weeks of age (adult).

[17:00] Any surprising findings?

• Active calcium transport genes in the duodenum were the same as in the distal intestine.
• Manganese afflux transporter was heavily stimulated.

[20:18] What was tested in the rodents?

[21:08] What about bile flow to absorb calcium?

[22:50] Implications for gastric bypass patients.

[30:30] Hypothesis: the importance of blood glucose: insulin ratio is similar to vit.D: parathyroid levels.

• Supplement with vit. D until parathyroid levels start to catch up.

[33:50] do obese people require more vitamin D?

[38:27] Does K2 help prevent calcification from higher levels of vitamin D?

[40:28] Take away for clinicians.

• They need to take calcium absorption into consideration.

[46:58] Vitamin D and viral infections.

• Inhibits inflammatory cytokines in mouse models.
• The position is a controversial one.
• There is correlative evidence but no mechanistic evidence.

[50:30] vitamin D as a precursor to LL-37.

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