Professor Argel Aguilar-Valles, PhD – Alex Leaf MS, CISSN

A group of proteins called 4E-BPs, involved in memory formation, is the key to unlocking the antidepressant effect of ketamine in the brain, according to researchers from three Canadian universities. The discovery could lead to better and safer treatments for certain patients suffering from major depression. PLUS If a young woman gets a virus like COVID and gets better her immune system develops antibodies that will be passed down to her offspring. This is one component of herd immunity. But what if a young woman gets the COVID vaccine and never gets COVID, but then has a baby? Is the immunity from the vaccine passed on to her baby? More importantly, this new mRNA vaccine is thought to have unknown effects on the mothers immune system that many scientist warn against. Is there the possibility of transgenerational epigenetic effects to be concerned about? PLUS Get the Dara Smart Scale from Fit Track and save 50% OFF. Go to http://GetFitTrack.com/shr today.

[3:25] What is Ketamine? Are there potential downsides?

[4:20] It has been tested in PTSD patients.

• It is not administered immediately after the trauma.
• It is only used for treatment resistant trauma.
• There is potential of abuse.

[7:05]  The “K-hole”

• A catatonic state from ketamine use.

[10:42] Unwanted effects from ketamine.

• Abuse potential.
• Can interfere with memory formation.

[12:00] what was the goal of this study?

• To understand how ketamine works.

[13:45] Study design.

• Mouse model.
• Used passive response to stimuli as a proxy for depression.
• 4-ADP gene was knocked out, one group had knockout from birth, others were knocked out in specific neurons.

[24:08] Suppression of mTOR can affect memory formation.

[34:39] Is there a way to make the treatment last longer without developing a tolerance?

[34:37] will rapamycin block the effect of ketamine in humans?

• It doesn’t seem to have those effects acutely in humans.

[41:30] What is the half-life of ketamine?

• ~30 minutes.
• Some of the metabolites have anti-depressant effects in mice.

[42:35] What about methylating ketamine?

[45:00] What about intra-nasal delivery?

[50:00] What role does the gut play?

[55:08] what should clinicians take away from this research?

[1:05:00] Invoking a vaccine on a pregnant woman.

• There is no data concerning pregnant women.

[1:12:47] What will it do to the child?

[1:15:16] mRNA drugs.

• There are decades of data on them.
• Why haven’t they been used in humans before now?

[1:21:06] The new “healthy” cover for Cosmopolitan.

• Obese people being proclaimed as healthy is only reflective of that particular snapshot in time. They are, at the very least, on their way to an unhealthy state.