Everyone Is Pre-diabetic + The Rattlesnake Wrangler

[5:33] Everyone is pre-diabetic?

• The reasoning is because of AGE production accelerates as we age, meaning diabetes would eventually happen to everyone, provided that they live long enough.

[7:53] What about the people that stay in ketosis?

• They are less glycated, for sure.
• But they probably didn’t start that life style until at least the age of 15 or so.

[8:50] Can glycation be reversed?

• It requires sugar, protein, and oxidation.
• 7 step non-enzymatic process to create AGE.
• There are many ways to slow down or block glycation.

[10:41] Decreasing sugar consumption.

[11:11] what role does iron play?

• It is a chelator and is positively correlated with AGE levels.

[12:00] The varieties of AGE’s

• The reality is that it is just more important to block AGE formation in general rather than focusing on the individual types.

[15:14] Will Age’s decompose in the body?

• You can urinate some of them that are in the bloodstream, but they are pretty sticky to tissues in the body.
• Carnosine ( or beta-alanine), vitamin B6, and metformin can all break up the process.
• Statins increase the production of soluble RAGE’s that bond to the AGE’s and are then excreted.

[18:25] Oxidation and inflammation.

• Free radical scavengers can reduce the production of AGE’s.

[20:37] Does berberine serve as a substitute for metformin in this case?

• They are probably moderately interchangeable.

[21:43] Do ketones have any beneficial effect on slowing down AGE production?

• It makes sense on paper, but Dr. Kauffman hasn’t looked into the long term effects.
• She speculates that it would be more beneficial to use this approach intermittently.

[28:15] Intermittent fasting.

• It can help with cleanup of intracellular AGE’s, which occur less than extracellular ones.

[32:00] Meal frequency.

• Higher frequency triggers mtor more frequently.
• The effect of this largely depends on if AGE’s are more influence by total glucose under the curve, the amount of times that blood glucose spikes above a certain baseline, or the amplitude of the actual spike in blood sugar.

[36:15] Does movement or exercise have a beneficial effect on blocking AGE’s?

[37:24] AGE’s in prehistoric people?

[45:20] Does nicotine play a role in glycation?

[45:50] what about gravity?

[47:10] Prednisone and corticosteroids lower insulin sensitivity.

[47:38] Hydralazine dosing.

• Lasts for about an hour in the body.

[49:30] GDA’s can block the formation of AGE’s

• Silymarin can as well.

[50:20] Glucosamine.

 [55:00] Alcohol.

[56:11] Sulfur containing compounds.

[57:11] NAC

[1:02:15] How Jerome ended up becoming a snake wrangler.

[1:07:06] Surprising aspects of working with dogs in the field of snake wrangling.

• The actual drive that the dogs have.
• Using voice and body language to establish dominance over the dog and be the pack leader.

[1:10:50] How did Jerome approach working in a 60 acre desert with dogs?

[1:14:50] How does Jerome actually gather the snakes?

[1:19:05] If a snake is caught, how likely is another snake to take its place?

[1:25:53] How people can contact Jerome.

[1:27:13] Does Jerome eat snake. What about recipes?

[1:31:10] How long would Jerome have to apply anti-venom if he were to be bitten?

• ~9 minutes.