with Guest: Dr. Dominic D'Agostino, Ph.D.
The number 1 killer of Americans is Type 2 Diabetes. Heart disease, cancer, kidney disease, high blood pressure, dementia and many more are just the results of Type 2 Diabetes. Insulin resistance is the cause of Type 2 Diabetes. When you love with elevated insulin for a long period of time you develop Type 2 Diabetes. Low to moderate levels of ketones seem to have the ability to suppress insulin response. Would exogenous ketone supplements have the ability to rescue someone from developing full-on Type 2 Diabetes? Can they also be used to help reverse Type 2 Diabetes? And if so, how should they be used?
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Show Notes:
Exogenous Ketones and Insulin Resistance
[5:20] Different rates of insulin desensitization in various tissues of the body.
[9:30] What direct effects to ketones have on insulin?
- Higher doses of ketones are not necessarily better than lower doses.
- They allow the body to utilize insulin more efficiently.
[19:20] IV infusion of BHB showed an increase in skeletal muscle protein synthesis in humans.
[21:45] Building muscle on a ketogenic diet.
[24:45] Caloric content of ketone bodies?
[34:09] Acute vs. chronic effect of ketones.
[41:53] How long do the effects of ketones last after administration?
- Electrolytes delay gastric absorption.
- Na- BHB on an empty stomach could be around 1.5 hours.
- A balanced salt profile may be longer.
[49:26] Consume with or before a meal if the goal is a healthy insulin response.
[56:26] Are the ester forms worth looking into if your goals are body composition related?
[1:02:00] Are testosterone levels affected by a ketogenic diet?
[1:05:17] Are ketone esters only effective when eating a keto diet?
- you can administrate them with a meal to decrease the glycemic response of a meal.
[1:07:10] Dom’s view on the carnivore diet.
[1:09:40] How do ketones lower gluconeogenesis?
[1:13:06] Elevated fasting glucose: could exogenous ketones make the situation worse?
[1:18:07] Ketones before bed for sleep.
[1:22:15] Ketones + goat yogurt for increased seizure threshold.
