with Guest: Dr. Elizabeth Yurth, MD
GLP-1 has been a mainstay in treating Type 2 Diabetes. As the name suggests its a glucagon mimetic peptide. We are learning more and more about glucagon and how it's an important player in regulating the insulinogenic response and also tamping down the negative effects of high insulin and glucose. Glucose signaling is what makes cells senescent. Could GLP-1 deliver on all the failed promises of metformin? You can get GLP-1 as a peptide at https://shrnetwork.biz/GLP-1 and use cod SHR for 10% OFF.
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Show Notes:
The Pep Talk: GLP1 For Weight Loss And Anti-Aging
[6:00] What is a GLP?
- Glucagon like peptide.
- Controls insulin release, insulin sensitivity, and satiety.
[8:00] How is glucagon important?
- It balances post-prandial insulin release.
[10:00] Can GLP-1 deliver on the failed anti-aging promises of metformin?
- The fat loss effects are not due entirely to how glp-1 affects insulins sensitivity.
[16:45] GLP-1 as an anti-inflammatory.
- Decreases or modulates several TNF’s, interleukins, NOS-2, cylco-oxygenase, crap, VCAM-1 and several other inflammatory pathways.
[19:00] Could it be beneficial for those with diabetic neuropathy
[27:50] Long and short-acting versions of the peptide.
- Broken down rapidly by dipeptidyl peptidase 4.
- Exenotide is broken down in 3-4 hours.
- Semaglutide- 1/week dosage. Showed more significant weight loss effects than short acting GLP-1.
- Semaglutide- improves satiety.
[40:00] Doctors prescribe but insurance usually wont cover it.
- ~$800/ month.
[41:30] How fast do people see results?
- They usually see results on a weekly basis.
[55:21] Sildenafil.
- It is being used in conjunction with tesomorelin to beige fat cells.
- Can aid in reversing NAFLD.
