[00:00:00] [00:00:00] Carl Lanore: [00:00:00] welcome back to another episode of superhuman radio. This is fast becoming the most popular show. We do on the network. It's the pep talk it's where we explore new and exciting peptides peptides are basically emerging science that only the doctors on the bleeding edge of medicine today are actually paying attention to your not going to walk into a GPS office and say hey I heard about this peptide.

[00:00:24] He's gonna look at you like you have three heads and rightfully so because he hasn't been trained in these things and they don't even know where to get trained. So I'm going to do two things at the top of today's show. First of all, I have to say Today's Show is dedicated to a good friend of mine named Curtis Dunn  .

[00:00:39] We've been training at the same gym for a long time and he suffered a stroke not too long ago and he's been having a hard time coming back from it and I can see it in his eyes that he wants to come back and he's been seeing doctors. They offer nothing they offered nothing new and exciting. They offer nothing to him other than you know, just to go on with your life and none of us want to hear that right?

[00:01:39] [00:01:00] We want to be fixed now, right we want we want to know at least maybe not fix now, but we want to know that there's hope like oh actually may be able to get back to 99% of my past capabilities. And so this show is dedicated to to Curtis. Number one number two, if you're a physician and you've been told.

[00:01:20] Listen to Today's Show by a patient or a colleague and you want to be trained you want to know how to take advantage of these new and exciting therapies. They are legal for you to prescribe. But where do you learn about peptides to I'll tell you where you go to the international peptide societies webpage and you join.

[00:01:42] And you get trained by some of the most brilliant physicians in the space about how these peptides can be used to help you do the what you went to medical school to do and that's help people help people not medical coding and all [00:02:39] that other nonsense that you're caught up and but actually give people the kind of results that they're looking for.

[00:02:04] So today's show is dedicated to talking about peptides that will help. Resolved and recover from stroke and traumatic brain injury and and see a CTE chronic Encephalitis, which causes the degradation of brain tissue over time. And obviously once you lose that real estate, it's hard to ever get it back.

[00:02:25] And so today we are re joined by dr. Elizabeth yearn. How you doing?

[00:02:34] Dr. Elizabeth Yurth, MD: [00:02:34] Dr. Yurth and

[00:02:35] Carl Lanore: [00:02:35] you also have a colleague with you today, and that's Brian Graham. How you doing, Brian?

[00:02:40] Brian Graham: [00:02:40] Yes, I'm doing very well. Thank you for having me and Brian actually was instrumental in this discussion because he's actually working at your clinic specifically on peptides that help people with brain injuries, but also help prevent them from happening in the first place if you are in a contact type sport, so you're going to want to really pay attention [00:03:39] because let's face it prevention is absolutely a better approach than having to fix something after.

[00:03:07] Conrad

[00:03:07] Dr. Elizabeth Yurth, MD: [00:03:07] they're playing catch-up is never easy. So that's what we're trying to mitigate with these programs were developing here.

[00:03:12] Carl Lanore: [00:03:12] So, dr. Yours I want to start with you because I want to talk about the areas of opportunity when we talk about the brain the things that we want to influence in order to affect recovery and resolution from a brain injury, whether it's an ischemic injury or a blunt force trauma type injury.

[00:03:33] Dr. Elizabeth Yurth, MD: [00:03:33] So that's that's really what it is. I think have a novel approach that we really have no ability to do with any other medications right now. There's not your friend. I'm sorry to hear about him. There's really not anything to offer these people from the traditional realm and and the same thing is true for post-concussion.

[00:03:51] We sort of say okay rest your brain, but really not anything to offer us when we look at what happens with these brain injuries Strokes. Traumatic brain injury that's sort of a host [00:04:39] of events. And it one of the big things is that there is a big down the blood-brain barrier and you get an influx of things that shouldn't really be in the brain and that are damaging to the brain.

[00:04:10] And so that's one of the things that you want to sort of hold early. So you need to improve the metabolic changes that are occurring at the brain very acutely to the injury and the more acute that you can treat those patients. So they're closer to the time of the injury the better off you're going to be.

[00:04:27] Guillermo's me to look at is how do you get more blood flow back to the brain Whenever there has been a stroke typically at least an ischemic stroke not so much Strokes can be bleeds or they can be ischemic but there's compromise to the vascular flow and we all know if you stop the blood flow to your pinky finger.

[00:04:44] It's going to die and fall off and the same thing is true of your brain. He dropped blood flow eventually that portion of the brain is going to die. And and obviously unless we could revascularize it acutely. There's going to be long-term consequences associated with that even [00:05:39] small concussions. We can see on MRI scans for down the road people who have had concussions and you'll see these little spots in the brain these little white spots in the brain that are areas where the brain has lost blood flow.

[00:05:14] In general we say oh, well, they're small. They didn't do anything, but they do and the more those occur the more problems you're going to have and so we really have to get Neil that we call neovascularization. We need new blood flow. Other thing you have to do is to really restrict the excited Tessa T.

[00:05:35] So when there's been damage to the brain. There's this excited toxic responses and you get changes in good file and peroxidase superoxide dismutase all these pieces that increase oxidative stress to the brain. So we want to be able to reduce oxidative stress to the brain and help the brain heal and there's certain peptides that we can use that will help do that in our [00:06:39] own day-to-day existence every day.

[00:06:02] There's octaves dresses that are occurring to our brain. And the way we typically recover from those is deep sleep we sleep and the more time you spend in deep Sleep. That's what we kind of we consider the cleanup period of the brain the more time you can spend in deep Sleep the more likelihood that you're going to reduce those oxidative stresses during deep sleep.

[00:06:24] There's actually a better interchange of getting the Trashy stuff out of your brain. So if. Sleeping poorly waking up a lot. For some reason then you're going to have more likelihood of damage the brain. We all a lot of people in our world use these oil rings, and those will tell you how much time you spend in different stages of sleep and if you're not spending adequate.

[00:06:48] In deep Sleep, your brain never goes in those cleanup phases so we can actually use some peptides that will help to sort of induce those phases as well. So we can see that that changes the oxidative phosphorylation [00:07:39] neovascularization. And then really, how do we now get new brain cells to form we used to think that you couldn't do that.

[00:07:08] I used to think that damage the brain is damaged the brain and you can't regain gain it but we now actually know that you can. You can get sprouting a brain cells you can get new brain cells so we can actually repair damaged brain. So where the old Paradigm was. Oh, well, once there's brain damage.

[00:07:25] There's brain damage. That doesn't it can be fixed it can and we can use peptides that really help that though. There's peptides that will improve things like brain derived neurotrophic Factor. We called bdnf that will potentially help to repair. Brain tissue that's already been damaged. So it's not a lost cause once you've had these injuries or you started out of half already of early Alzheimer's or early cognitive impairments.

[00:07:51] Carl Lanore: [00:07:51] So the three areas of opportunity if I could summarize our improved blood flow [00:08:39] or what we really want to do is we want to actually stimulate. New Blood Pathways into the brain because whether it's blunt force trauma or ischemia, what ends up happening is blood stops getting into their oxygen stops being delivered blood sugar stop being delivered.

[00:08:19] So basically you're shutting the Machinery down number one which in and of itself can cause death never mind that the actual event. The other thing is. Metabolic debris or metabolic waste removal, right? You have an ischemic event. You've got all of this necrotic tissue and it just I mean just just think about it, right, you know you if you have dead skin on your arm, it's you got to get rid of it in order for the healing process to start in the first place.

[00:08:45] And then and then the last opportunity is what I'd like to call new neuronal sprouting new nerves. Kind of growing around where you know nerves are funny there just if anybody who likes gardening which I hate [00:09:39] gardening but Eliza has taught me to like it. You know, when you when you take a rosebush and you prune it right beneath the prune spot you have new growth that come out and grow around it and neurons do exactly the same thing.

[00:09:13] We know that neuroplasticity. Which we did an entire show about yesterday a quite frankly neuroplasticity exists. Even in the Aged brain when certain things are done when you improve blood flow when you reduce metabolic waste and we're going to call oxidative stress part of the metabolic waste process and you then can do things that stimulate new neuronal sprouting.

[00:09:39] The brain will actually re collateralize around the damaged area. And fix itself. So this idea that I've had a stroke and and I've lost these faculties and that's it for me. That's not true. Am I being too simplistic about [00:10:39] this?

[00:10:01] Dr. Elizabeth Yurth, MD: [00:10:01] No, I think that's a nice simple, but correct summary of it. Let's add one more thing because we're becoming more and more aware of inflammation as as a culprit in all of these injuries as well both in cognitive impairments as well as in these post traumatic injuries.

[00:10:17] And so I think the other thing we really need to look at are things that reduce inflammation in the brain and and that is that ties a little bit into all of that, but it may be as we're finding with everything Cancers and. Inflammation is super important address that's difficult to address in the brain.

[00:10:34] We actually have you and I talked a little bit about a new peptide. That's just come to Market that may have a very anti-inflammatory effect on the brain. So that maybe one more so the fourth thing that we really need to look at is how do we reduce inflammation?

[00:10:45] Carl Lanore: [00:10:45] So I want to add to that for a second because I think that by and large many people don't understand the role of inflammation versus what happens when chronic inflammation occurs.

[00:11:39] [00:10:59] So inflammation is a signal to the body to pay attention to this tissue and repair it. But what happens in an environment where we are chronically inflamed and we're talk about we talk about over activation of the immune system. So when we talk about inflammation, we're talking about the army of the immune system the immune system is tasked with going and cleaning up metabolic debris, but here's the problem.

[00:11:26] If you have fire departments all over your city and they're all sitting there waiting for a fire to break out in the big fire breaks out downtown and three of them can dispatch their Crews and their trucks that one fire and put it out and everybody goes home. This is great. This is a perfect example of inflammation something sticks.

[00:11:42] Its head up the body goes. Let's get it. We resolve it. We fix it we go back to the Firehouse. Everybody goes to sleep. But if you have a city that's burning down. The fire department can't respond. They just can't and and they don't even know what to respond to because is this fire more of a [00:12:39] threat than that fire.

[00:12:01] This is what happens in the chronically inflamed person. This is why chronic inflammation actually stalls the healing process quite frankly. It also affects mood. Memory and so many other things when we talk about the brain, but but inflammation is important but chronic inflammation is the pox on fixing anything in the brain.

[00:12:25] What do you think about those?

[00:12:27] Dr. Elizabeth Yurth, MD: [00:12:27] That's exactly right. It's a really good point. There is a difference between acute inflammation, which is necessary for healing in Orthopedics. We've started using for instance platelet cells stem cells for the same purpose. We have a chronic injury or body is its it has a disrupted immune function to that area if we can recreate an acute inflammatory response.

[00:12:48] Sometimes we can encourage healing. So that's great acutely long-term. It does damage and so is a very distant acute inflammation and chronic inflammation. You're right what we're speaking to here. Is that chronic [00:13:39] inflammatory changes? Bring dimensions. For instance. We now are thinking of almost like a type for diabetic, you know, because we know that the chronic inflammation occurs from high blood sugar to the brain is very damaging to the brain.

[00:13:13] And so you're right. We make a big distinction between chronic and acute inflammation

[00:13:18] Carl Lanore: [00:13:18] lot of my bear. I'm not ignoring your question, but I can't answer it this early on in this interview. But if you stick around I promise that question will be answered about your wife. Pre perimenopausal and migraines will talk about that at the end of the show.

[00:13:32] I just don't want to derail the discussion about stroke and an ischemic events. So let's go to Brian for a second. So Brian is your specialty is. Not necessarily working with people who have had an ischemic event or the Damage Done, but you're working on some projects with individuals like football players and so on who have contact Sports who are prone to ending up with multiple events and protecting their [00:14:39] brain in advance talked about that before we start talking about stroke and CTE and all out of this.

[00:14:05] Correct. So again, what we're talking about is

[00:14:08] Dr. Elizabeth Yurth, MD: [00:14:08] nipping it early. We are addressing these issues early on so they can't have this Cascade of events that has a

[00:14:15] Carl Lanore: [00:14:15] host of

[00:14:15] Dr. Elizabeth Yurth, MD: [00:14:15] issues

[00:14:16] Carl Lanore: [00:14:16] that

[00:14:17] Dr. Elizabeth Yurth, MD: [00:14:17] we're trying to play catch-up

[00:14:18] Carl Lanore: [00:14:18] with

[00:14:19] Dr. Elizabeth Yurth, MD: [00:14:19] so specifically the touch on kind of re capture what you guys were discussing discussing is working of the neuroprotective side and the neuro restoratives guide.

[00:14:28] This is modulated through blood flow. Through inflammation through improving metabolism, you know things of that

[00:14:36] Carl Lanore: [00:14:36] nature

[00:14:36] Dr. Elizabeth Yurth, MD: [00:14:36] when

[00:14:37] Carl Lanore: [00:14:37] our system is

[00:14:37] Dr. Elizabeth Yurth, MD: [00:14:37] primed. It is better suited to handle an event

[00:14:41] Carl Lanore: [00:14:41] of

[00:14:42] Dr. Elizabeth Yurth, MD: [00:14:42] trauma, for example, and one thing I'd like to add with that inflammation, especially with the brain the brain tends to set up a perimeter

[00:14:52] Carl Lanore: [00:14:52] around that injury around that in Seoul

[00:14:54] Dr. Elizabeth Yurth, MD: [00:14:54] so that inflammation spreads or beyond

[00:14:57] Carl Lanore: [00:14:57] that injury or.

[00:14:59] So when we [00:15:39] can

[00:15:00] Dr. Elizabeth Yurth, MD: [00:15:00] turn off that inflammatory Cascade early on we are essentially mitigating that collateral damage. So yeah again just a touch on we are pre treating people. We are setting them up with protocols or regimens that basically optimizes their system to better deal with a stress and Insulin to turn off that inflammatory Cascade early on

[00:15:22] Carl Lanore: [00:15:22] then

[00:15:23] Dr. Elizabeth Yurth, MD: [00:15:23] modulate blood flow immediately.

[00:15:25] Turn

[00:15:25] Carl Lanore: [00:15:25] on

[00:15:26] Dr. Elizabeth Yurth, MD: [00:15:26] the metabolism. Up regulate those things that we need to that side of trauma.

[00:15:32] Carl Lanore: [00:15:32] What happened type. What peptides are you using? Let's say a stack that you're using to help pretreat someone before the actual event.

[00:15:42] Dr. Elizabeth Yurth, MD: [00:15:42] So the ultimate regular with thought about his VPC 157 that were so familiar with I mean, it's capacity and modulate blood flow and inflammation is key.

[00:15:51] Actually doctor if you don't mind touching on that compelling Mouse study, I know there's a mouse model but it is it's incredible just to talk [00:16:39] about in the first of all the safety tolerability behind me. You see I mean is is incredible itself,

[00:16:06] Carl Lanore: [00:16:06] which I

[00:16:07] Dr. Elizabeth Yurth, MD: [00:16:07] have no hesitation with

[00:16:09] Carl Lanore: [00:16:09] administering

[00:16:10] Dr. Elizabeth Yurth, MD: [00:16:10] or recommending this to patients as far as its safety profile really coming down even very young people, right?

[00:16:15] You audiences. We know very familiar very um, very bright audience is familiar with a lot of these things btc-e talked about before but we we love PPC and there's a great study that came out about a year ago where they actually took my sin they dropped a weight on the Mouse's head. And importantly could you imagine could

[00:16:35] Carl Lanore: [00:16:35] you imagine the mice when they all get together?

[00:16:37] What's your study about? They're gonna give me testosterone and I'm going to copulate all day long. What about you? I'm gonna drop a weight on my head. Yeah one

[00:16:45] Dr. Elizabeth Yurth, MD: [00:16:45] group and actually pretreated them would be PC and actually not a not a super-high dose of those would be very reasonable to use in humans.

[00:16:53] It wasn't this massive dose and that group when they drop the way in their head actually came out of it being [00:17:39] able to function like a normal Mouse the. Group went on and had the same load had severe traumatic brain injury to the point where they could not function. They couldn't see they couldn't walk.

[00:17:11] So it's really incredible how neuroprotective it is. So one of the things Brian has been trying to do is sort of get that word out to our athletes. Especially our young football players. We you know boxers those people who are going to suffer. Brain trauma can we protect against that you know, we are all too familiar.

[00:17:32] Now with the ongoing worry of format product traumatic encephalopathy. I have five kids. I wouldn't let any of them play football and and yet I patients who were football players and you know, if you're a football person you're going to let your kid play football if that's the case. I think these kids should be protected.

[00:17:49] And so one of the things we're doing is trying to get to the training rooms Bryan trying to get out there and talks of people realize there is things that we might be able to do. Yeah,

[00:17:57] Carl Lanore: [00:17:57] just doesn't let me let me ask [00:18:39] you a question. So we just we just did this whole dissertation about the importance of understanding and inflammatory response and bpc is being used.

[00:18:09] I use half a milligram injection post-workout I use a half a milligram on days off because it helps you recover. Well the fact that it helps you recover does it not say that it's a most probably one of the most powerful resolving agents for inflammation. 

[00:18:31] Dr. Elizabeth Yurth, MD: [00:18:31] And remember that you're right. We do want some acute inflammatory changes, but you don't want in the brain particularly.

[00:18:39] You don't want a massive inflammatory. That massive inflammatory response actually has some very negative effects in the brain. It's what we call secondary trauma that occurs with influx of things that actually cause. Damage it so the brain is a little unique in that you don't want a big huge inflammatory response [00:19:39] like you might if you have a wound that needs to heal so really the brain is a little unique in that realm and so probably the way VPC is working a bit protectively is set is avoiding the secondary influences of the metabolic changes that occur we call heat shock proteins that occur that start a whole Cascade of damaging events.

[00:19:22] After the initial trauma, so you avoid that secondary trauma, which we actually think is may be worse than the first trauma to the brain

[00:19:28] Carl Lanore: [00:19:28] interesting.

[00:19:29] Dr. Elizabeth Yurth, MD: [00:19:29] It's for a question

[00:19:31] and

[00:19:31] Carl Lanore: [00:19:31] then that makes perfect sense from an ischemic point of view. A lot of people get worse the weeks after a stroke then immediately after stroke because what's happening is in an attempt for the brain to go and fix things and you end up with all these workers and all this concrete splashed everywhere and everything around.

[00:19:51] The area that was damaged now becomes hyper inflamed and it's thought to become damaged as well. So that's an interesting interesting observation going to Brian. I didn't mean to cut you off

[00:20:39] [00:20:00] Dr. Elizabeth Yurth, MD: [00:20:00] now just to say I like to look at it more as a modulatory are fighting the sense that when it's needed the troops

[00:20:06] Carl Lanore: [00:20:06] are

[00:20:06] Dr. Elizabeth Yurth, MD: [00:20:06] upregulated to that side of trauma or to that side of need and then when it's not needed things are quiet and disappears not this up regulation or this.

[00:20:15] Anti-inflammatory constant effect, it has an ability to

[00:20:21] Carl Lanore: [00:20:21] up

[00:20:21] Dr. Elizabeth Yurth, MD: [00:20:21] regulate inflammation down regulate inflammation and again assists ultimately. It's an ultimate module ettore peptide,

[00:20:28] which

[00:20:28] Carl Lanore: [00:20:28] is why

[00:20:28] Dr. Elizabeth Yurth, MD: [00:20:28] it's so exciting to be so effective. And so well tolerated.

[00:20:32] Carl Lanore: [00:20:32] Okay. Yeah,

[00:20:32] Dr. Elizabeth Yurth, MD: [00:20:32] that's a good point. We always tease be called PPC the own knowing peptide because it kind of pick it up bring it down regulate its why it's so safe.

[00:20:41] It doesn't really ever over do anything. And so it sort of has this very nice balancing effect. And you know, first time we ever heard about the PC years ago. We're like, okay surely those not something that really is that all knowing but PPC really does seem to kind of come into play when it's needed and not be in play when [00:21:39] it's not and so I

[00:21:00] Carl Lanore: [00:21:00] like I can't I can't help thinking about adaptogenic compounds when I think about your discussion because like PPC is that it is an adapted genic peptide.

[00:21:08] Yes.

[00:21:08] Dr. Elizabeth Yurth, MD: [00:21:08] You're right. That's a good way to put it.

[00:21:10] Carl Lanore: [00:21:10] Yeah. Yeah interesting. So let's go on and start talking about I'm going to throw some peptides out and speak about them and how they affect the three different or four different areas of opportunity that we discussed. I remember early on some of the early research on thymosin beta for showed that small amounts 1 to 2 milligrams within six hours of an ischemic event, whether it was brain or cardiac by the way six months out.

[00:21:40] There was no collateral damage necrotic tissue was reduced. It was almost like the person didn't have the stroke people have argued with me and said that's in rodents. Not in humans. What do you think about thymosin beta for having it as a rescue? Like I having it in your freezer never using it but kind of like breaking the glass and pulling the alarm [00:22:39] using it post post ischemic event.

[00:22:01] What do you think about.

[00:22:04] Dr. Elizabeth Yurth, MD: [00:22:04] All right, that's key again that you hit the nail on the head when you said they use it as a rescue power of that and the fact that it is so angiogenic isn't to be taken lightly. So I think its effects and its benefits are very powerful and need to be utilized correctly. If you want to improve right it has a huge engine guy that can you write what we want to get more blood flow to that area to heal tissue.

[00:22:30] It's a it's an incredibly powerful and we use it a lot for people post injuries any of our post-surgical patients things like that will put them on since time is in beta for they'll heal much more rapidly and I agree we do the same thing with happy will keep 5 has an alpha 1 around in case they get viral illnesses because it will stabilize the immune system, but that isn't made for as a very very Pro angiogenic effect.

[00:22:51] That's. You post that ischemic stroke. That's exactly what you need. You don't want to do that forever and ever right? Because we know that same Pro [00:23:39] angiogenic effect could have downsized. We don't want to just keep having more and more and more cell growth that's cancer, right so so but unlike BBC, which is very.

[00:23:10] Gary regulatory to itself I'm Savannah not quite so much and we love Stuyvesant beta but it is one that we say, you know use with a doctor or somebody was a certified peptide specialist who understands. How do you use it how long you use it will kind of doses to you use it for what purpose I think it's hugely powerful.

[00:23:27] It's hugely beneficial. It's one of those big guns that you got to know how to use correctly.

[00:23:31] Carl Lanore: [00:23:31] Okay with that being the case is there. Is there a window of opportunity with diamonds and be informed that closes if someone has a stroke in January there listening to this show today? They're going. Wow.

[00:23:42] I wonder if tv4 would help me. Is it too late for tea before to help?

[00:23:48] Dr. Elizabeth Yurth, MD: [00:23:48] I don't think so because that's a bit of for is going to have your we can use a post chronic injuries as well to help heal tissue. So I do think if you put it in with a host of a few other things that [00:24:39] that for making me if we increase princes bdnf brain-derived neurotrophic factor, and we're trying to increase neuronal sprout.

[00:24:07] All that also needs more blood flow. So I actually think that I'm some better for can be pulled in in a chronic event is well used for a brief period of time maybe a 12-week period for instance to really help encourage increased blood flow to the area. So we will use it down the road as well. I mean we are hopeful that my body is going that direction and re-establishing that blood flow to that area is just such a glacial process and the

[00:24:32] Carl Lanore: [00:24:32] power behind

[00:24:33] Dr. Elizabeth Yurth, MD: [00:24:33] peptides is that we can really kick that into overdrive.

[00:24:36] Really get those results that we're looking for a lot quicker. So that's the idea behind

[00:24:41] Carl Lanore: [00:24:41] that. Yeah. I want it. I want to inject something here early on no pun intended because what we're really talking about here is is leveraging neuroplasticity, which is a phenomenon that we all possess when all switches are turned on but but from all of my experimentation with things like LSD [00:25:39] and micro dosed LSD and other bdnf Regulators.

[00:25:04] It's the magic doesn't happen. When you're using these agents. The magic happens actually when you stop using them and the next couple weeks because what happens is when you turn bdnf on and you turn blood flow on and you turn neuronal sprouting and you turn vascular endothelial growth factors and other growth factors on.

[00:25:25] What you make your brain do in the next two weeks determined the trajectory of what it's going to fix in your brain. So if you use these things and you just sit in your chair for two weeks don't expect a lot to happen, but if you use these things. And you go out and you do the things you used to be able to do all be it.

[00:25:44] You're not gonna be able to do them. Well, but if you do that what you're telling your brain is, these are the things I want you to fix. So these none of these agents will work if you just take them and sit home and watch TV all day long. You must go back out just like you did as an [00:26:39] infant and learn to walk again and start doing these tasks so that the so the Machinery you've turned on.

[00:26:06] Goes, oh, we're going to be doing this every day. We better start fixing this area of the brain. Is that an overstatement doctor your Earth?

[00:26:15] Dr. Elizabeth Yurth, MD: [00:26:15] Yeah. That's great. We're actually one of my other professionals and I were doing a podcast and he actually brought up that point even in people like you and I who if we want to trust maybe try and improve memory or something.

[00:26:28] Use the peptide at the same time go start taking guitar lessons go start learning new language. You actually want to create that neuronal sprouting in the way to do that is to exercise the brain in a behavior. It's not used to it similar to you know, if I want to go the muscle I can't just take growth hormones pretty gods and sit in my chair.

[00:26:47] I need to go to work the muscles that I'm trying to grow. And so we do we really, you know, Brian when he's talking to these patients says, okay. And again again even in you and I use these peptides [00:27:39] and then go out and actually try something new learn something new do something. In the person whose post traumatic brain injury, you know, they often times are pretty limited, but that's a window of time when you get them and you really start start having them learning these skills or we learn these skills that's incredibly important for tonight and I'm glad about that even recommending visualization techniques proposed

[00:27:24] Carl Lanore: [00:27:24] as

[00:27:25] Dr. Elizabeth Yurth, MD: [00:27:25] a limit screen time.

[00:27:27] It limits the mental stress to an extent where again it is at their own capacity.

[00:27:33] Carl Lanore: [00:27:33] But when they

[00:27:34] Dr. Elizabeth Yurth, MD: [00:27:34] have those techniques on board, would you see a greater more profound? On their ability to

[00:27:40] Carl Lanore: [00:27:40] another one. I'd like to throw out is that we know is also a nootropic but it does increase be bdnf but more importantly it really has a profound effect on blood flow and anything has a profound effect on blood flow is going to also answer that second requirement of being able to reduce metabolic debris because when the blood [00:28:39] gets in it takes stuff out with it and that is die.

[00:28:03] Hexa now. This is a transdermal that I rub on my neck a few times a week. And when I take six to eight clicks, I feel it. I literally feel like it's not a stimulant but I just feel like all of a sudden I'm wide awake would die. Hexa work for someone in a post ischemic or a TBI type of an environment.

[00:28:27] Dr. Elizabeth Yurth, MD: [00:28:27] Definitely because they have cellino has a snap to genic effect. It's actually creating new synapses between those neurons. So we actually want your brain one message to get from here to here to here and I have some seems to have a very important role there. So they had to actually maybe meet me play a little or no.

[00:28:46] These other peptides do in this Improvement and synaptogenesis. It also appears to have a. So it was called a pass like growth factor and it also [00:29:39] probably has a big role in sort of clearing out the bad stuff. But some pretty novel the work. They don't Parkinson's patients and die. Hexa they've actually reveal not just prevent worsening of the disorder but really completely in some places normalizing motor function and these patients and that's probably it's synaptogenesis effect is improving the messaging between the neurons.

[00:29:23] Carl Lanore: [00:29:23] Very interesting Brian

[00:29:25] Dr. Elizabeth Yurth, MD: [00:29:25] you were in here. He has clients out of patience to talk a lot.

[00:29:29] Carl Lanore: [00:29:29] You know, what will get it. We're going to take a break anyway, and we're going to come back. I want to talk about dsrip a little bit because even though it's considered a slow asleep peptide. It seems to be in the Wheelhouse of this discussion Brian.

[00:29:40] Thanks for being here today with us.

[00:29:42] Dr. Elizabeth Yurth, MD: [00:29:42] We thank you very much where

[00:29:43] Carl Lanore: [00:29:43] we're going to take a quick commercial break. We'll be right back with more of dr. Yurt States. Welcome back returned with dr. Betsy. Ryan had to leave we have a little background noise again. Do you hear that? It's a little bit just a tiny bit.

[00:29:59] I [00:30:39] don't know if it's an open door or something like that. But anyway, it's not it's not terrible. Don't worry about it. Anyway, so let's talk about DS IP. I use the SI P because it's called deep sleep inducing peptide, but it did not do anything to improve my sleep. In fact, I didn't notice anything at all about it, but then I read in recent study.

[00:30:20] That shows that dsrip seems to improve blood flow to the brain dramatically. What about DS IP as a player in resolving a stroke and or TBI Uncle

[00:30:34] Dr. Elizabeth Yurth, MD: [00:30:34] so I read it we have excited about the SI P for all our people who can't sleep. Yeah, I seen a where people come back and go. Oh that was the answer for me.

[00:30:47] There are few people who do seem to respond really well to it from that role. But for the most part I agree with you, but it does potentially play a huge role in a whole lot of other processes and brain repair may be one of them. It does [00:31:39] appear and when you look at people who use the or ring we can measure.

[00:31:03] Deep sleep the even though people don't seem to have their they still had more trouble falling asleep is so maybe wake up their deep sleep time definitely does improve so even sometimes though. They don't they don't feel like they were sleeping as well. They probably got more efficient sleep and as we mentioned before that period of time is a very very important time for the brain to heal itself.

[00:31:24] And so if you if you don't get enough deep sleep you're going to have some issues. So we can induce a higher period of time in deep Sleep post these injuries. That's a really nice time for that clean up that I remember you talked about all that cellular debris that occurred that that period kinds of we can get deep sleep up to over an hour in the post traumatic brain injury people or in the stroke people.

[00:31:47] So we want to look at that their deep sleep. I like to actually measure that in our in our in anybody who have caught those cognitive impairment and try and get them up to a higher percentage 30% of their time in deep sleep. We'll get more repair mechanisms these IP as a very [00:32:39] interesting response also in that.

[00:32:02] Through mood regulating so it called deep sleep inducing peptide which makes it sound like you're going into a coma but it actually does not make you feel groggy. So if you took it even during the day, so people there hasn't been a fits on atth so stress relieving you can use it for instance people who have addictions you can use it to help them with addictions because of its effect on ACTH.

[00:32:28] So it's really nice if you know anybody who is withdrawing from. Or wants to get off of opioids or alcohol. It's really as a nice effect there because of some of the stabilization of on the adrenal gland. The other thing interesting about the sap in this may have again to do with some of its deep sleep inducing effects is that it affects luteinizing hormone and has subsequently testosterone so you can actually lose the SI P used appropriately at night.

[00:32:51] You can see boost in testosterone by about a hundred points and we talked about testosterone and subsequently some of its romanization to estrogen and how beneficial that [00:33:39] maybe. To bring hewing as well. Yeah, that may be another place where DS IP may be having some some interesting benefits. So I agree with you.

[00:33:09] I think it's name is a little deceptive deep sleep inducing peptide because all of us. Just think of it's going to put us into a coma but think more about that deep sleep period if we can even really increase that significantly and people who are trying to recover from a stroke that you're going to see a period of brain healing that they they're they don't typically get lives to do more of its job.

[00:33:30] It probably is working a lot on oxidative stress is during that period of time so it's probably the main effects.

[00:33:35] Carl Lanore: [00:33:35] So one of the peptides I want to talk about and. A lot of people are going to think wait a minute Carl why this peptide for this discussion and and I want to talk about it now because you said, you know anything that seems to cause a rise in luteinizing hormone seems to improve the quality of Street sleep architecture.

[00:34:00] [00:34:39] When I first started using HCG at a hundred I use a night before bed. I doubled my deep sleep and it continues to be there as long as I keep using HCG. The reason I want to talk about HCG now because it is a peptide and I don't want to get off on to sex steroids and their role in inflammation and and recovery for the brain, but you did kind of mention estradiol.

[00:34:28] After dollars a powerful anti-inflammatory at it actually activates the inflammatory process that this suppression of information by docking in a receptor called the faf fibroblast activation factor receptor, which every cell has it actually could shut down inflammation in a chronic situation. And so instead of talking about hormones testosterone and their role.

[00:34:49] I want to talk about HCG. Hey, you know we talked about how women are much more complex than men because they actually can manufacture another [00:35:39] human being and as a result of that women possess a variety of systems that are designed to bio. Hijack the body to allow it. To have and build a human being even if the environment is hostile, right?

[00:35:17] One of those things is HCG because 8cg seems to be. And adaptogenic peptide in causing the hormones to all be where they need to be for the next nine months. And then after that we can all fall apart. And so what about HCG in the recovery of stroke because of its Improvement and sleep architecture, but also its ability to modulate and attenuate sex steroids.

[00:35:45] Dr. Elizabeth Yurth, MD: [00:35:45] I haven't seen and it's probably out there. I haven't seen any research on I think it's a great idea. I agree with you HCG has a dramatic effect on inducing deep sleep and you'll see you will see significant Improvement in deep sleep. So we've already talked about its benefit there. If you can [00:36:39] improve deep sleep you can improve recovery.

[00:36:02] I think it's Downstream effect on improving testosterone and and be acting as as again adaptogenic effect on our hormones is going to be huge as well. You're right has a. Very protective effect which is why you can be starving in the middle of Africa and and still have a baby who's born healthy.

[00:36:20] Right? Right. It's so if you think about its ability to act in a repair repair process, it's probably huge. It'd be interesting to see also go back and talk to kind of look at the studies on that and sort of see

[00:36:35] Carl Lanore: [00:36:35] it raises raises pregnant alone and raises progesterone. I mean, it's almost like. A super peptide.

[00:36:42] It's like anything that it's almost like snake oil. It's like anything that ails you because if you're if you're building a human being the body dedicates all its resources to that it'll steal minerals from your bones to give to the baby. All of that is is a result of the the [00:37:39] reproductive Fitness process that the body literally hijacks a woman's body and says, you know, I don't care if you're gonna die after this you're going to give birth to this, baby.

[00:37:09] Dr. Elizabeth Yurth, MD: [00:37:09] Right. Yeah and every type of PPC these adaptogenic peptides are so nice because there's that whole lot of downsides to them, you know, if you put somebody on HCG post-stroke post traumatic brain injury. Are you really going to have any downsides either female or male? No, you're really not going to see any huge risk to them.

[00:37:31] And so those things that you can use they have adaptogenic if that's anything that's adaptogenic remember it balances. It keeps things so you're not shooting well. You're lowering something else and so by doing that you have these great protective effect. So I think that that that would be interesting to go back and look at the studies.

[00:37:47] Are you aware of any studies on HCG? No,

[00:37:50] Carl Lanore: [00:37:50] I just make this stuff up. Dr. George. I really do. I'm not kidding. It comes it comes to me and I'm like, you know, it makes sense to me and my crazy but okay we'll go

[00:37:59] Dr. Elizabeth Yurth, MD: [00:37:59] back and [00:38:39] yeah, we'll go back and look and see what's out there. Yeah, and then we can do our own little experiment.

[00:38:04] Carl Lanore: [00:38:04] So let's talk about a couple other peptides that are kind of popular talk about C-Max see link. And also what's the one I take at night now isn't that funny? I just forgot it. But anyway, what about C-Max and ceiling? Yes

[00:38:17] Dr. Elizabeth Yurth, MD: [00:38:17] feel like C-Max and and definitely cerebra license because we love to rely some good sex as well.

[00:38:22] See I see that I can see Max are great because they're intranasal which is nice you don't have to inject them. And so something that can can get straight to the brain anything. You do intranasal can have a very nice neural effect because you can actually get to The Bravery easily right through the nose and that you can do surgery through the nose and get to the brain.

[00:38:42] So see that can see Max are. He first got to start in Russia and they're really nice peptides 44 anti-anxiety. So we you see like a lot as intranasal peptide and in it really [00:39:39] reduces and it really reduces anxiety. It's the balances neurotransmitters. It may it's a really nice actually interestingly.

[00:39:10] Breen performance-enhancing peptide. It was interesting. I was just doing a lecture put together a lecture on sort of sports performance. And in a lot of for instance a lot of Russia faces look no places that use more peptides and we do they put all their athletes on it because it actually helps you to not get stressed.

[00:39:29] If you're a football player and you have

[00:39:30] Carl Lanore: [00:39:30] a you they use it they use it with the astronauts that they sent up into space for longer the time of the space station. They give them it they give it.

[00:39:38] Dr. Elizabeth Yurth, MD: [00:39:38] Right exactly. And so if you can keep your brain sort of in a very nice mellow State the great military be another great place for this right you need to keep the brain really stable and mellow but still be able to perform to a tee.

[00:39:51] And so what it allows you to do is focus. At a very low so you so in a stressful situation keep your stress low and still be able to focus.

[00:39:59] Carl Lanore: [00:39:59] Do [00:40:39] you think do you think it's having an effect on one of the categories? You think it's increasing blood flow? Because the that's indicative of these the acute effects of being able to focus better.

[00:40:11] Dr. Elizabeth Yurth, MD: [00:40:11] I think it's it has less than engine Jack effect at the has. It's more its effect more on neurotransmitters is eyes angiogenic effect, you know, which is. It does have an antigenic effect. Always I love them. I think they're great, but they have a little bit more for risk right when we're increasing angiogenesis.

[00:40:30] If there is able cancer cells forming more blood flow to cancer cells is not a good thing. So I do think it puts into a little safer realm. It's been a really good peptide for us for some of our people with more attention deficit disorders things like that to help them with. But I've just started experimenting a lot with more are sort of precision athletes for us as people who are doing shooting competitions things like that.

[00:40:54] It's been really effective there. You can it's

[00:40:57] Carl Lanore: [00:40:57] cerebro licen you mentioned. So we were lice in is [00:41:39] also considered a nootropic peptide. How does it figure in what role does it play? Let's say in the resolution of stroke or TBI

[00:41:08] Dr. Elizabeth Yurth, MD: [00:41:08] surmise is really important for strobe resolution. And in fact in Europe, they do as an IV infusion.

[00:41:16] Add post stroke and as approval for that there it probably works best and in a pretty high dose Post drug. So if you could get somebody either IV infusion or willing to get themselves a fair amount injections post-stroke. It really does work better and a high volume when you're trying to improve post injury.

[00:41:37] Through life and really is a neural repairs and nootropic that has effect on Market improving brain derived neurotrophic Factor. So it's a really a no repair peptide. It may be for instance your friend who just had Struck. It may be one of the most important pieces in that healing recovery that can be.

[00:41:55] But again, we do think it may be need to be done at a very high level [00:42:39] the same thing true with your custom ative impairment patients or any kind of really more severe brain injury. You have to get a lot in and so IV infusions or a lot of. But again, it is also been used actually interestingly enough in ocular migraines.

[00:42:16] He had someone who talked about migraines that may be more hormonal migraine. He was describing but but ocular migraines, it improves synaptic function, it proves bdnf. We use it a lot protectively. I do a lot of genetic analysis our patients one of the genes we look at our people who don't produce enough bdnf.

[00:42:38] And working with coming down that actually your border called soma Logics that's actually measuring proteomics. So we actually can look at proteins and see oh, you're not making enough this protein. Can we improve it? So you can use a preventively in that in that realm. So I get myself I have a gene that I'm a mother with dementia.

[00:42:56] I have a gene that I have less bdnf. So I use [00:43:39] herbalife's and every day just to raise

[00:43:01] Carl Lanore: [00:43:01] how much should I use 250 milligrams a day. Is that what you use? Yeah, okay. Okay. That's

[00:43:08] Dr. Elizabeth Yurth, MD: [00:43:08] right. I mean yeah, and you know and some people have a hard time probably post injury you need to get a double that right you need to use very high doses of and that's difficult and expensive.

[00:43:19] The

[00:43:19] Carl Lanore: [00:43:19] other peptide I want to talk about is actually possibly from the research one of the most important. peptides in the role of resolution of a stroke or TBI and actually perhaps not just arresting but reversing encephalopathy and that is the FGL parentally L2. Can you talk about that? This is a relatively new peptide.

[00:43:45] It's a synthesized peptide. It's not something we make naturally, is that correct? Right.

[00:43:49] Dr. Elizabeth Yurth, MD: [00:43:49] It's 64 FG Loop peptide and it's I think it looks almost called a cell adhesion natural cell adhesion pregnant wrong [00:44:39] Natural Health cell adhesion molecule and it it probably works in two ways one is that it actually is this is expressed on glial cells.

[00:44:11] So there's ncam. This FTL is expressed on glial cells and you can directly create this fibroblast growth factor. So again, it's improving fibroblast

[00:44:24] Carl Lanore: [00:44:24] growth and that's and that's a problem has growth factors improve neuronal sprouting. It's like putting Miracle-Gro on your rose bush. That's what a fibroblast growth factors.

[00:44:35] Do they make nerves grow,

[00:44:38] Dr. Elizabeth Yurth, MD: [00:44:38] right? It appears that it's working very specifically. On these on these brain neurons, right? So it's it actually has an effect on like the glial cells. And so it may be one of the few things that we can do that really is a very very direct effect on the cells that we really want to treat and as I really just came out of it which is published like three weeks ago showing that it has a [00:45:39] mark benefit for hippocampal inflammation at this is where your memories are stored.

[00:45:05] And so when you look at at any Strokes that affected a lot of micro ischemic. And so people are hybrids chronic hypertension and develop dementia has a lot of those are micro ischemic Strokes. So we'll T Strokes at the hippocampus and So eventually they they lose any bility to remember anything.

[00:45:23] And so it may have a really nice effect on hippocampal repair and also reducing inflammation the hippocampus which may be key to some of the Alzheimer's. Patience. So I think it's just starting and some studies in could it really be a very novel way to treat treat Alzheimer's related dementia because of its effect on hippocampal damage and hippocampal repair hippocampal inflammation.

[00:45:46] So it's pretty cool. It's very new and I think we're just kind of getting into into using it more the I don't have any clients yet. And so we sort of have to play with it a little bit more

[00:45:56] Carl Lanore: [00:45:56] so this. Is designed to be a [00:46:39] primer and if all I want to achieve with today's discussion was to let people know that there exists these therapies for people who have had Strokes or traumatic brain injuries chronic traumatic brain injuries, and now it told that they're suffering from encephalopathy.

[00:46:15] Their brain is literally starting to shrink. It isn't what you think it is. There are things that can be done. But you need to find a doctor you can't this information is to tell you that there's hope. But you need to find the doctor. If you are out on the west coast, please plug you're going to take a break and come back and answer Mike Bears question, but plug your.

[00:46:39] Dr. Elizabeth Yurth, MD: [00:46:39] So we're in Boulder in the foothills of beautiful Boulder, Colorado. My company is borderline Longevity Institute, and we actually have one of the few medically managed peptide programs we go through a very comprehensive program with our clients and and love forget to give us a call and talk to us more we will do some phone consultations and we can work in about eight different [00:47:39] states my license or you can fly here and see if it's a good vacation spot.

[00:47:05] I did what I always show the slide what I'm talking about about brain injuries and peptides always Show a slide of like a shaved head with a tattoo that says if you can see this, please call peptide specialist

[00:47:16] Carl Lanore: [00:47:16] that's good.

[00:47:18] Dr. Elizabeth Yurth, MD: [00:47:18] You know you and I get in a horrible injury. We want somebody there right away right has it was injecting stuff into us because we want that repair to start right away and unfortunately, There's not very many doctors were Savvy to that.

[00:47:31] So we really want REO our spouses to be equipped with a little packet that they have.

[00:47:35] Carl Lanore: [00:47:35] Yes. Yes. Yes. I have a freezer full of things that I only will use the day that something happened to me Boulder longevity.com is the website. If you are a physician or you want your physician to be able to do this sort of stuff.

[00:47:47] Tell them to look for the international peptide Society get trained and they can have prescriptions filled at tailor-made compounding in Nicholasville, Kentucky. We're gonna take a quick commercial break. We're going to deviate a little [00:48:39] bit slightly from the discussion and come back and talk a little bit about migraines.

[00:48:03] We're going to answer Mike Bears question. Stay tuned. You know, what dr. Your I forgot to ask you a critical question. A lot of these therapies were talking about obviously work best if the intervention occurs soon after the ischemic event or the traumatic event, but what if somebody is had a stroke like my friend Curtis done, I think he had the stroke of the beginning of the year maybe.

[00:48:26] Maybe it was the end of last year. Is there still hope for him to leverage some of these therapies to help regain more of his faculties?

[00:48:35] Dr. Elizabeth Yurth, MD: [00:48:35] I'm definitely we've seen with yes. We were licensed. I hexa that you can have a very reparative effect. So where is the early stage of treatment is often times designed to?

[00:48:48] To prevent the damage right to prevent the damage that's great. Once damage has occurred. We still are going to get benefit by increasing blood flow increase in neurogenesis. So I think that the combination of [00:49:39] using Daihatsu perhaps, you know, this new this new peptide FGL the the FG Loop peptide and super weisen bpc still have marked benefit and we've seen that we actually have had some patients who were pretty.

[00:49:15] Pretty more traumatic brain injury probably seeing don't more traumatic brain injury in this clinic, but had pretty severe damage. We had a woman who was a lawyer who got a bad cards and really. Yo, because very dysfunctional she couldn't and she was three years post and by using a combination of three glycin actually see lank helped her with kind of anxiety piece of that.

[00:49:38] We used to rely sun' and it'll die. Hexa and be PC and she was able to. Improve significant is three years of doing everything traditional medicine had that offer her and she still needed help with basic tasks around the house. She got back to actually working part-time. And so we're seeing that was three years post.

[00:49:56] So I think there's significant benefit that you can get from the [00:50:39] peptides even pretty far down the road. Let me the hexa study with the Parkinson's patients should repair motor neurons. These are patients who have who have been years and years and years ago,

[00:50:11] Carl Lanore: [00:50:11] The peptide I couldn't think of before which I've been using just the five milligrams proof before bed is at Battalion that's been shown to increase melatonin production penal on production and some of the other pineal gland.

[00:50:25] Would that be beneficial just from a street sleep architecture or use any extrinsic value to every towel on when we talk about stroke?

[00:50:33] Dr. Elizabeth Yurth, MD: [00:50:33] Well, I'm an episode of the Huey peptide right improves from race activate activity. So it's sort of what we consider longevity peptide no sense. So from that, well, maybe I'm not sure it has a very direct effect.

[00:50:43] Probably it's indirect effects in terms of improving improving. Oh, well hello is rightly so but I'm not sure we have as much

[00:50:54] Carl Lanore: [00:50:54] on, correct? Okay, let's ask let's oh Mike Bear ask the question and [00:51:39] I've seen this so many times now. It's just crazy. His wife is going through the change of life. She's going through menopause and she suffers from violent monthly especially the migraines what can help so I have an opinion.

[00:51:13] I'm sure you have a very educated opinion. What could Mike's wife do other than get on HRT? Yeah,

[00:51:21] Dr. Elizabeth Yurth, MD: [00:51:21] big thing that happens and this is sort of and young girls when they're first starting to get their period but then women perimenopausal is it you sent it to be very estrogen dominance phase and so you have a lot higher estrogen levels than progesterone levels.

[00:51:33] That's probably the main cause remember right before women get their period their progesterone levels drop and so that now they become very estrogen dominant and it's explains not only the headaches but why women get through mean and bitchy and a key and everything else is this flop and. Runs a lot of women really respond to mad with simply to Progesterone.

[00:51:54] We also now now and kind of bring it to the peptide realm you might have heard. It was called the council Tony related [00:52:39] peptide. These are actually drugs that have been recently introduced that actually inhibit a peptide because we know that one of the things that that estrogen dominant may play a role in it and why my grades are more common in women is.

[00:52:13] Upregulation of something called calcitonin G related peptide which causes significant meningioma. And that may be a bad thing. That's why long term migraines. You can actually look at an MRI scan somebody who has repented migraines and see changes that look similar to little vascular insults. So if I look at a patient when they're 70 and see these little changes I can predict that they had migraines for years and years and that maybe the fact this calcitonin jira that peptide Cosmic man angel.

[00:52:41] So if progesterone is not enough you can sometimes throw in something to inhibit. There's two companies now that they've medications that you inhibit calcitonin junior-level a peptide. So we're talking about all the great benefits of peptides. Well, there's some peptides that when they get to high great problem.

[00:52:59] Cal [00:53:39] Stones emulate peptide RC G RP being one of them and we know that those that peptide becomes particularly problematic to women right about the time when their estrogen levels are must significantly higher than their progesterone. So you have to achieve that balance between estrogen progesterone progesterone.

[00:53:15] So so so helpful for women in migraines. It's amazing. I always and depression and anxiety. I always say that very few women come to me with Prozac deficiencies a lot more come to me with progesterone deficiency. But they've been treated with Prozac to treat it. So I think that that may be really a simple solution and if you don't just want to go to a doctor and do it, you can even go over the counter and buy even topical progesterone at a health food store.

[00:53:43] You have to use a lot of it, but that sometimes even that can help so I encourage you to look into that as well as if that doesn't help the sea grp Inhibitors have been. Pretty significantly beneficial their objections. You give yourself once a month. It's a little injection. You give yourself once a month.

[00:53:59] [00:54:39] It blocks the high-velocity grp, which tend to fluctuate and become higher or it may be that women become more sensitive to it right around the time of their periods want

[00:54:08] Carl Lanore: [00:54:08] to see grp stand for

[00:54:10] Dr. Elizabeth Yurth, MD: [00:54:10] calcitonin G related. Okay.

[00:54:12] Carl Lanore: [00:54:12] So so one of the things that affects calcitonin is vitamin D, so a vitamin D levels.

[00:54:18] Get very low your parathyroid has to produce more calcitonin because it has to do the work for mineral absorption that the vitamin D would have done so would would be wise for her to a go and have her vitamin D levels tested.

[00:54:35] Dr. Elizabeth Yurth, MD: [00:54:35] Definitely I check my bindiya all we do it everybody because there's so many so such far-reaching effects, but you definitely want her vitamin D levels to be above 60 that seems to be the level where we start if it falls below that the migraines become more significant as well.

[00:54:50] Don't trust that you said your doctor said, oh her vitamin D levels are normal because Normal on a blood test is anywhere from Thirty to a hundred if your levels are before

[00:54:59] [00:55:39] Carl Lanore: [00:54:59] during the 30s. You're sick. Yeah,

[00:55:02] Dr. Elizabeth Yurth, MD: [00:55:02] exactly

[00:55:03] Carl Lanore: [00:55:03] and you see how dark I am. Dr. Betsy. I don't know if you could tell in this light.

[00:55:06] But Eliza Eliza said that I'm too dark now. I need to stop laying in the Sun but I'm a sun worshiper because I I believe in evolutionary medicine and I think that the best way to get my vitamin D is to get out there in the Sun and lay in the Sun and let my body do what it does best. So another thing Mike is that she could get out in the sun more assuming she's not fair skin start slow, but there's another thing that I want to bring into the discussion.

[00:55:31] And the early 1920s before migraines were called migraine. They were called hypoglycemic headaches. They were called hypoglycemic headaches because they saw that when women especially when into deep bouts of hypoglycemia. They ended up with tunnel vision severe pain sensory changes and they called them hypoglycemic headache somewhere along the line the name changed to migraines and they knew that.

[00:55:58] They were [00:56:39] preceded by a sensation. We most people who have migraines they'll tell you. Oh my God, I'm going to have a migraine something happens. They get a tingling in the back of their neck their Vision twinkles. They see an aura something changed. No, I'm going to have a migraine and usually the migraine comes on within minutes.

[00:56:18] To you know, a couple dozen minutes from that from that initial sensory situation. So the two things that we've done shows on was the use of exoticness ketones number one if you take an exogenous ketone dose of. Nine or more grams of beta-hydroxybutyrate when you get that sensation, the migraine either doesn't come on or last a couple minutes and goes away number one.

[00:56:44] And why is that because if in fact it is truly a hypoglycemic event giving the brain a different substrate to power itself saves it from feeling like it's starving and causing these events. Number one number two. Dr. Betsy just said something that's critical.  [00:57:39] What progesterone is low? And a sturgeon is high women have a really hard time managing blood sugar.

[00:57:07] This is why they get hot flashes. They get subjective Tremor they get anxiety. These are from hypoglycemia. So they're on this rollercoaster of high and low blood sugar levels and by her. Going online and buying an over-the-counter 2% or even 5% progesterone cream and starting to use it a couple times a day and low doses of pump here pump there.

[00:57:31] She may find out that all of these events go away completely right completely, but the reality is the real thing and so Mike put up there that. Let me put up some of his posts. So the doctor wants to put her on birth control. I've never heard of anything. So stupid in my life cause she's not gonna have babies anymore.

[00:57:50] She doesn't need birth control. She needs bioidentical HRT. Then he put on we just started her on magnesium 400 and vitamin D magnesium is good. That's actually very very [00:58:39] good because magnesium helps to change both glute for and insulin sensitivity. So yes, she will see less probably of these events.

[00:58:09] Dr. Elizabeth Yurth, MD: [00:58:09] Although 400 milligrams is probably too low, but I'm

[00:58:11] Carl Lanore: [00:58:11] just going to

[00:58:13] Dr. Elizabeth Yurth, MD: [00:58:13] say yeah underdose her vitamin D as well. She needs probably at least 5,000 IU's of vitamin D at least 500. I would say a thousand milligrams. Magnesium to really get a significant, you know, riboflavin magnesium vitamin D butterbur all helpful.

[00:58:27] But ultimately quite frankly. These are probably progesterone induce headaches. Yes.

[00:58:34] Carl Lanore: [00:58:34] Yes, I agree. I agree and and he said that I named her symptoms. So I'm going to tell a funny story and I'm going to end the show.  in 2000 and in 2002. I got very sick. I was using a lot of performance-enhancing drugs and I was using aromatase Inhibitors and I actually gave myself menopause.

[00:58:58] In fact, I know that I gave [00:59:39] myself menopause because I was using drugs that didn't aromatize like Trend ballon and I was using an aromatase inhibitor. And I started to develop insomnia subjective Tremor. I felt like somebody stuck a vibrator up my but I but no one could if I said feel my hand, I don't feel anything God I'm shaking like a leaf.

[00:59:17] I don't know if I started getting hot flashes sweating. I anxiety I was drove myself to the hospital one night because I didn't know what was wrong with it. And then I went on a website called power surge. I put my symptoms in and all of a sudden I was surrounded by all these women and I thought wow.

[00:59:35] If guys went through this they would have found an answer to menopause years ago, but I gave myself menopause. That's why I know these symptoms might because I lived with them for about a year until I figured out what was wrong with me and I got my testosterone levels back up and blah blah blah, but the reality is that she would really do well going to see someone here in Louisville.

[00:59:54] I go see somebody like dr. Carl page. He can get her straightened out. He could put her on [01:00:39] bioidentical HRT. He's even a member of the international peptides aside and he can work with peptides with her because what she really needs to do is get on HRT. She needs to see her testosterone and progesterone or estrogen all those levels are and get them straight.

[01:00:14] What do you think? Dr. Betsy and

[01:00:16] Dr. Elizabeth Yurth, MD: [01:00:16] the birth control pill is going to actually have the opposite effect. It's going to it's a high-dose estrogen. So now we're. Going to be higher. It actually does not have progesterone and it has progestins which are not the same thing. So actually any progesterone she has gets further suppress.

[01:00:32] Her headaches will get worse and she loved all the other bad consequences of having high-dose estrogen. Suggestions which were probably more carcinogenic and this is a really simple fix with a good dose of progesterone balancing the hormones. It's so important and remember the my guys are just underlying symptom of inflammation.

[01:00:51] And and so. The low progesterone screen information other places as well. It's why we see women that age also start to get more joint pain those receptors for [01:01:39] progesterone on our joints. So the joints will get stiffer and a cure and so progesterone it at such a cure-all for women. They sleep. It's amazing.

[01:01:08] Carl Lanore: [01:01:08] Did we miss anything on the landscape of the peptides for stroke and traumatic brain injury recovery?

[01:01:16] Dr. Elizabeth Yurth, MD: [01:01:16] I just want to say a little bit about using things that raise igf. So because when you can get igf up that also is really important for for posted particularly immediately post injury. In fact, we've seen that very high levels of igf-1 immediately post-injury have a very very nice effect on not getting that second those secondary excited toxic effects of the brain trauma.

[01:01:38] It's not

[01:01:39] Carl Lanore: [01:01:39] great.

[01:01:40] Dr. Elizabeth Yurth, MD: [01:01:40] So I don't forget our civil ones that we sort of think of more forms our overall health muscle building that things like CJC and if Merlin or even sometimes stronger things can be really helpful for like your friend you definitely want those types of things.

[01:01:53] Carl Lanore: [01:01:53] Where are you? So I for many years I used igf-1 long are three.

[01:01:58] Fairly high doses [01:02:39] I've used up to a milligram a day and I tried to make it site-specific. So I would inject it directly into the muscles that I had trained. Are you a fan of igf-1 long are three do you think it's a mistake to just up regulate and and use something so long acting

[01:02:14] Dr. Elizabeth Yurth, MD: [01:02:14] I think sometimes it has really nice benefits.

[01:02:18] For instance if I had a traumatic brain injury or stroke I would want igf because you really want a very potent. Idea simulator that's by far the most poems that there is. I don't use it much in any other realm because I do think it's difficult and that you it probably has a it's a quite a little too strong and does it's hard to regulate enough but I definitely acutely Post-it brain injury think I've if it was me I put myself on a high dose igf stimulate repair time.

[01:02:49] Carl Lanore: [01:02:49] Hi, so I think that your your last Point here is great because it's kind of like saying okay, we're going to plant this Garden. Let's start with really good dirt, and the [01:03:39] foundation of your garden is the dirt you start with and in this case here growth hormone and all of its Downstream metabolites must be in place for things like, you know famous in beta for leverages growth hormone and growth factors without the growth of a growth factors.

[01:03:14] It doesn't do its job bpc 157 leverages growth hormone and growth. There's without the presence of those growth factors. It can't do its job. So you ending the show on that point is critical without good soil. You're not going to grow to good tomatoes. That's all there is no doctor your thanks so much for making time.

[01:03:33] I know you're very very busy. Thanks for being on the show today.

[01:03:36] Dr. Elizabeth Yurth, MD: [01:03:36] Thank you, Carly. I was little I love talking to you.

[01:03:38] Carl Lanore: [01:03:38] Okay. Take care. We'll talk to you soon. And that's it for today. Please feel free to share this show around this show can really help a lot of people. There's a lot of people out there who are going to suffer from stroke have suffered from stroke or traumatic brain injury, and this show may actually change the outcome of their lives.

[01:03:55] Thank you for listening today. We'll see you next week [01:04:39] .