[00:00:00] Carl Lanore: [00:00:00] welcome back to another episode of super human radio. Today is, uh, February seven, 2020. And this is a, an episode of probably one of the most popular shows I do every month. And that is the pep talk. We're going to be joined by dr Elizabeth w U earth in just a moment. Uh, but before we do that, a couple of things I have to do.

[00:00:21] First, of course, I have to thank our title sponsor legendary foods for being such a bunch of great people and supporting this show. If you love the information that this show puts out there, and we put out more information, any other podcasts out there? I do four shows a week on average when most guys are doing one a week.

[00:00:40] And I've been doing it for 14 plus years now. Uh, this is the oldest and longest running health fitness, anti-aging podcast in the world. And it's here because of you right now, whose ears I'm lending to speak to. And legendary foods is our title sponsor. So you [00:01:00] need to show them love because they make this show possible with a huge grant that keeps me in business, even if I lose other sponsors.

[00:01:06] And . They currently have a a pop tart, like a snack called the tasty pastry, and if you haven't tried it, you have to because it tastes like a pop tart upgraded and it is upgraded because it's got nine grams of protein, less than one gram of sugar, a three to four grams of impact carbs. It is just the healthier way to feel like you're cheating.

[00:01:33] And of course they also have fantastic myriad of other fantastic products, different nut butters. I've shown you the empty jars that I go through eating them here with the spoon at my desk. I'm seasoned and flavored almonds. Go to eat legendary.com and uh, and tell them that Carl sent you. And without further delay, I am going to bring my guest on the brilliant [00:02:00] dr Betsy earth.

[00:02:01] How are you doing Betsy? I'm Greg

[00:02:03] Dr. Elizabeth Yurth, MD: [00:02:03] Carl. Thanks.

[00:02:04] Carl Lanore: [00:02:04] Yeah. And so people, everybody's just sitting around. You've already like been working since what 6:00 AM this morning? You've seen how many patients did you do any surgeries today too? You're like, wonder woman,

[00:02:14] Dr. Elizabeth Yurth, MD: [00:02:14] you're one clinic today. So DHA injections and some knees and uh,

[00:02:21] Carl Lanore: [00:02:21] yeah.

[00:02:22] Yeah, very cool stuff, right? Very, very cool stuff. I had somebody say to me this morning, wouldn't it be cool if if dr  was your physician? I said, she can be. I said, reach out to the clinic. I said, my friend Shawn 

[00:02:34] Dr. Elizabeth Yurth, MD: [00:02:34] from 25 different States.

[00:02:36] Carl Lanore: [00:02:36] That's awesome. That really is awesome. And by the way, I every week get contacted by somebody who has understood.

[00:02:45] The benefits of peptides and says to me, do they have a peptide for depression? And I've always said, no, not really. But they do, don't they?

[00:02:55] Dr. Elizabeth Yurth, MD: [00:02:55] Yeah. It's pretty new. And this is, this is, this is pretty new lesson. And so [00:03:00] we, we are actually really excited when just start using it in the practice. Um, you know, in the past we really have not had a whole lot of options for people.

[00:03:08] And so it's really nice to have some options to treat people now with depression. But as you and I get into talking about this. It's going to have actually a whole lot more value. I keep ready to start seeing if maybe for cardiac conditions, for other, other neurologic disorders like, uh, specific evidence for epilepsy and stuff.

[00:03:25] So

[00:03:28] Carl Lanore: [00:03:28] let's address the problem first. Further. Every day someone is being put on SSRI SSRI is ruin your life. They literally so, so. I used to joke with people and say if, if your hand was killing ya and I stomped on the instep of the foot, you wouldn't think about your hand anymore cause there's new paint is now distracted.

[00:03:46] You and SSRS distract people. They don't mitigate. They don't make depression go away. They just make you feel so out of sorts that you don't even complain about your depression anymore. You just don't have anything anymore for life.

[00:04:02] [00:04:00] Dr. Elizabeth Yurth, MD: [00:04:02] I think it's one of the big complaints about SSRI is, I'm not going to doubt, I think there's people who need them and I think that they have saved lives.

[00:04:08] I think the problem is that the right antidepressant for the right person is very difficult to figure out. They all have side effects and people do say, you know, okay, I maybe don't feel like killing myself anymore, but I actually feel like I don't feel anything. I'm not feeling particularly joy. I'm not.

[00:04:27] I mean, I don't feel like I have the same compassion for people. So we get that complaint a lot with antidepressants that people just no longer feel like themselves. And that's a huge issue. So, so I'm, I'm not gonna say that they're not unnecessary drug, and I do think they've saved lives, but it's a difficult, that's a difficult road to hoe.

[00:04:47] And the reason that we don't, that we keep looking for some other options, and I think most recently try and ketamine infusions, things like that, is because we haven't found successful options.

[00:04:56] Carl Lanore: [00:04:56] Well, I mean, as that's all rise also re are [00:05:00] reported by patients that not working. About 30% of patients claim that they don't do anything at all for them.

[00:05:05] The other 70% they're doing something, but we're just not sure why. Right 

[00:05:12] Dr. Elizabeth Yurth, MD: [00:05:12] with now that found that genetically there's people who there that none of the SSRS are going to work, that they just don't carry the genetically, the effect of that there are going to have any value. So I think that the studies show that the first and the present you're put on, you have a 30% chance of it working and then if you fail that one, actually, your re your likelihood of getting better for the second one you put on is even lower.

[00:05:35] And the third one even lower than that. So it ends up, if you don't respond to the first and depressant that you're put on. The likelihood of you actually ever getting better. For me, those drugs is probably pretty small. It's very sad to say, we failed in this system. We need to find something else. And so far the first of all, industry hasn't come up with that,

[00:05:52] Carl Lanore: [00:05:52] don't have an answer or no will.

[00:05:54] In fact, uh, less than, um, one third of patients get [00:06:00] relief from depression, from any of the treatments that are currently considered the standards of care for depression. And this is really sad, um, because. Depression is a disease that, I mean, you could be big and strong and healthy and, but you just don't, you don't have, you don't have anything for your life anymore.

[00:06:19] I mean, it's got  we've all been depressed. You know, when, when I had my mother, father, and sister all pass away in a short number of years, I became depressed for a good year. But I knew I'd get out of it. I just knew my body had to adjust it to, to this trauma, and I would come out of it and I did. But there were a lot of people who just, waking up in the morning is not an exciting thing, and that's a way, way sad way to get through life because we see people out there with one leg and one arm and half a face and they're killing life.

[00:06:47] They're enjoying life. They're like, I'm not letting this stop me. And there's a, here's a healthy person, just doesn't even want to engage in life anymore. It's very sad.

[00:06:55] Dr. Elizabeth Yurth, MD: [00:06:55] And it's a silent problem, you know, especially among men, right? Women maybe are a little [00:07:00] more trained to reach out men not. So it's a, it's, it's not like that, but it's something that, that people aren't being treated for.

[00:07:07] It's not working. And a lot of people don't even want to talk about it or complain about it. Uh, I was really, before the podcast, I have two very close friends who, who've, uh, committed suicide. Both physicians, both males, both seemingly fine making good incomes. Have you had good families? We're married and, and you know, very close to me.

[00:07:26] So this is a, you know, a huge issue. And I think they actually both were on antidepressants and, and, you know, and, and so not helping them.

[00:07:37] Carl Lanore: [00:07:37] I mean, I mean, let's, let's not forget Robin Williams, who was diagnosed with Parkinson's disease, but didn't decide to kill himself until he went to the doctor, said, you know, I'm depressed.

[00:07:46] The right thing to say to Robert is, look, man, I know you're depressed. In fact, I knew I was dying. I was going to be trapped in my own body. I be depressed too. So they figured, well, let's help them out. We'll give them an SSRI. And then he hangs himself like, what, two weeks later, three weeks [00:08:00] later. So, and, and, and also.

[00:08:03] Um, let's not forget all of the young children who will put on antidepressants very early on whether or not they commit suicide, their brain chemistry is jacked for the rest of their lives. I mean, that is scary to me. We don't know yet. These, this new batch of, of, of, of kids we have today that are just turning 20 and so on now who've been on antidepressants since they were like 14 years old.

[00:08:31] We have no idea what they're going to be like when they get to be 40 and 50. Right?

[00:08:35] Dr. Elizabeth Yurth, MD: [00:08:35] Yeah. It's a, it's an experiment, you know, society. Uh, and this random, I would tell you the number of people I see in an orthopedic clinic. Who are in a depressant and, uh, is probably 50% I mean, so this is not a small problem.

[00:08:49] And a lot of them have issues even orthopedically that we can kind of track back to some of the things that are going on with some medications, maybe the depression itself, but also medications.

[00:08:58] Carl Lanore: [00:08:58] So we

[00:09:00] [00:08:59] Dr. Elizabeth Yurth, MD: [00:08:59] have, so we have a lot to address here, and I hope that we maybe have, it has something that's going to

[00:09:06] Carl Lanore: [00:09:06] help us.

[00:09:06] So let's talk about this. So let's talk about Spaten. Is it proud spaded a Spotify. Standing straight. And so what exactly is speeding?

[00:09:15] Dr. Elizabeth Yurth, MD: [00:09:15] So sustain as is endogenous peptide. We actually, people make spades and it basically blocks what's called the Trek one receptor. So this is the receptor, the Trek receptors, which stands for twits related pro potassium channel receptor.

[00:09:31] There's a bunch of them, but there's Twix. One receptor is very much itself. It's an electric excitable receptor. Dictated by potassium influx, and it's very related to depression. Um, it's related to memory loss. Dementia is, it's related to epilepsy. It's related to anxiety. So it, when that receptor is activated or excited, it accelerates.

[00:10:00] [00:10:00] Dysfunction. So loss of neurons in the hippocampus, which is our memory center. It accelerates depressive symptoms, anxiety symptoms, and it very upregulated epilepsy, because you think of that, that is a neuro excitable entity. So if we can block that receptor, then we can potentially halt or slow down those diseases.

[00:10:23] So we have this natural way of doing that. But if that is not, you don't have enough state in or for some reason your receptor is upregulated or there's other things going on genetically, environmentally, chemically. Well, then we have to intervene. And the SSRI, some of the antidepressants do work on this receptor.

[00:10:41] The problem is they work on a whole lot of other pieces as well. Hence their side effect profile.

[00:10:45] Carl Lanore: [00:10:45] Right? So there's this, this peptide works exclusively on that receptor. Let me ask you about this. You know, we say, Oh, it's, it's a potassium channel and we move on off. So, um, we know that people are severely depleted in [00:11:00] appropriately.

[00:11:00] Electrolytes in the body because of highly restrictive diets. You know the number one problem with the kedo diet, a high fat, moderate protein, no carb diet is both magnesium potassium levels go wonky. And so the lot of these people end up with keto flu. We now know that if they supplement with minerals, the kettle flu never happens.

[00:11:21] What happens. If you're severely depleted in potassium, does that, does that play a role in some people maybe not producing enough of this peptide? Uh, endogenously?

[00:11:35] Dr. Elizabeth Yurth, MD: [00:11:35] Cause I don't really know the answer to that. I'm not sure we have, you know, all the information about that, you know, is this receptor changed by potassium dysregulation?

[00:11:44] Yes. So, so it speeded itself change? I'm not sure about that. I don't know the answer to that. Um. The problem was fading is because our body is in this very kind of always modulating state is it's very, very short lived. It appears. And when five seven minutes, it's [00:12:00] gone so that you can turn on and off these receptors rapidly.

[00:12:04] So the problem with trying to treat somebody with spade in is I can get five minutes of making you, you know, blocking the receptor and then it's got. Uh, and so, yes, use his spin directly is not in a very effective, you know, and that's why it kind of had gotten looked at by the pharmaceutical industry years ago.

[00:12:21] And they said, listen, it's going to work. We can't treat somebody for five minutes. Right.

[00:12:25] Carl Lanore: [00:12:25] So, so now, so that, that brings up the actual peptide. I just want to get this up there real quick to, uh, there are some studies that show that Trek one is also implicated in anxiety. And I have some anecdotal information from a friend of the show.

[00:12:40] Uh, Victor, uh, a misfit. And he is using, he's on his third day of a P E 2228 which is the actual. Analog of spading, which appears to work, bred at better. I'm gonna let you explain that, but he says he's only been on it three days and they say it takes about four days to work. Think about [00:13:00] that. When you talk about SSRS will take four to six weeks to work the, this works at about four days if it's going to work for you.

[00:13:06] And he said, what he does notice is some nootropic effects is his mind feel after he takes his nasal spray. He said he feels like the lights go on in his brain. He feels like he can think clearer thoughts. A memory comes back about things. There may be a new Tropic value to this half.

[00:13:23] Dr. Elizabeth Yurth, MD: [00:13:23] The definitely is.

[00:13:24] So when you talk about the anxiety aspect, definitely. So we know that this receptor is linked, as I said, not just to depression, to anxiety. So upregulation of this, this neuro excitable receptor, you're going to see more anxiety again in extreme States. So stimulate the brain that you get his epileptic tax, but anxiety, depression.

[00:13:40] So, so we know it's related to anxiety, but we also know that it's, again, really up-regulates. Brain drive neurotrophic factor and also improves HIPAA Campbell. Again, that's your sort of memory center. Neurogenesis. We actually are seeing within. Days. [00:14:00] Again, there's very few things that we'll do this. The days you're seeing an improvement in memory in people and improvement in anxiety and improvement in depressive symptoms, so within like, like like pictures at three days.

[00:14:12] There's no drug really that we can put somebody on almost that you can, you can see that affect me. peptides are  and we know that's one of the cool things about them, but to save somebody who's really depressed and I give them. An antidepressant medication like Prozac, and I go, okay, in about three weeks, let's see.

[00:14:30] If you feel better, you're massively depressed. So I need them in three weeks. Let's see if you feel better. Because it takes that long. It takes three weeks for an antidepressant, really on effect, it's not gonna make them feel particularly good. And in that three week time. Who knows what happens,

[00:14:46] Carl Lanore: [00:14:46] right? So blah, blah, blah.

[00:14:47] I don't want to gloss over this three week period because there's two, two problems with this three week period. Number one, the onset of effectiveness. If you are testing one of the drugs with, let's face it, you're basically testing it cause it doesn't [00:15:00] work for everybody. The three week period that you have to wait in order to test it.

[00:15:05] So let's say you do this and it makes you feel worse. Well, guess what? It's going to take two or three weeks for your brain chemistry to come back to normal. They could probably go want to titrate the dose down half for the next two weeks, half for the next two weeks until you're not audit. Cause they always tell you don't ever just stop an SSRI.

[00:15:23] Yeah. You know what that's like? It's like jacking your car up, taking the tire off, and then kicking the Jack out before you put the tire back on. Your brain goes. What the hell just happened? You jacked me around for the past three weeks has sent me down this road. Now you took my confidence away and you told me find my way home.

[00:15:39] Your brain doesn't like that.

[00:15:42] Dr. Elizabeth Yurth, MD: [00:15:42] Yeah, and so now you've got through all that and now you have to try another drug and go through the exact same event again. I'll try this one and let's wait three weeks and if that last times, if during that three week trial they are having all these other symptoms. Well, what the traditional doctor says to them is you just need [00:16:00] to wait it out because it can take a while to get through the side effects and then see if it's having an effect.

[00:16:05] So not only are you going to three weeks of feeling worse with your depression, but you're having these horrible side effects. Somebody has told you to just wait out. It's hard if you've been ever, you know, and I'd never been in a massively depressed state like that. I've had some situations of oppressions, but to be in that state and have somebody tell you that.

[00:16:20] I, I don't think it's going to go well. Um, and so, so and then, and then we say, okay, well that one didn't work because now the traditional thing is go to your second line defense and we have no tricks. You know, I just told you the fact that he did not respond to the first drug, what time you responded to the next line of drugs is even less.

[00:16:39] So now you're like, this is even less. But we go to the same game of three weeks trial with more side effects. We need not that one trying another one. So now, maybe nine weeks into this show, you failed three, three trials, and now people are like, well, we could try electroshock. You know, let's look at Bolsa therapy.

[00:16:55] Carl Lanore: [00:16:55] My mother went through that and my sister went through it, and it's, it's, it's gut wrenching. Yeah, and [00:17:00] it's, it's horrible. It's, I, I still can't, it's so barbaric that if I just don't understand why modern medicine is still using electroshock there. And they say it works for people with Parkinson's disease, they seem to see some benefits.

[00:17:12] I mean, well, I guess if you get hit by a car, something good could come out of it too. But, you know, why do it.

[00:17:20] Dr. Elizabeth Yurth, MD: [00:17:20] Well, if you're massively depressed and nothing has worked and nobody has anything else to offer you, and again, I think it's another 30% of people who will respond to EZT, but we tell them, you tell them you also are going to lose a lot of your memory.

[00:17:33] You're also going to lose a lot of cognitive function. So you're doing it at an expense. It's a last ditch effort to try and save someone's life who is massively depressed with a lot of side effects along with it. So not a great option. We, you know. People won't try. And ketamine therapy, Ken is interesting because it actually does have some similar effects to, to the, uh, PE 20, 28.

[00:17:54] So there's some similarities to the way they work, but ketamine has a lot more risks as well. Uh, it's hard [00:18:00] to titrate, very expensive. And it, it also, you know, it's, um, it's, it's working on the mTOR pathway, so we're screwed up a lot of different other pathways with it as well. So its side effect profile is considerably higher, so, so we've exhausted everything.

[00:18:15] So you're a depressed person and you and you are not one of the lucky 30% who actually responded to your first SSRI pretty much. Now, people just kind of go

[00:18:24] Carl Lanore: [00:18:24] get used to it. Now you know that old saying you could get used to hang in if you're hanging long enough. Well, okay, but now I want to stay with this just for one more second, because you and I had a little off the air discussion.

[00:18:36] You know. As I said, when I lost my mother, father, and sister, in a short period of time, I became very depressed. And it caused me a lot of grief for about a year. But I knew I would get past it and, uh, and, and once I kinda got used to it, but taking an SSRI. Was it an option? Because I know it takes four, six 46 [00:19:00] weeks for it to actually start to work and it doesn't work for most people, and if it doesn't work, then it's going to take me four to six weeks to feel normal again and what's normal by then.

[00:19:08] And I thought, Oh, I wouldn't now look at this, look, look at PE 2228 so you, let's say you lost your job, you're really depressed, you're sad, but you know you're going to feel better. You just don't want to be, feel this way for the next couple of months until you snap out of it. Here's something that. Kicks in fast and you can just stop when you're done and you're

[00:19:29] That's, this would be a much better rescue method. Treatment for people who are suffering from major depression where we know they're going to get over it. They just went through a divorce, they lost a child, a childbirth. We know you're going to get a, and what about for mothers with postpartum depression?

[00:19:44] Here's the drug, here's what you give them.

[00:19:46] Dr. Elizabeth Yurth, MD: [00:19:46] Nights might be a really nice option for that. Your low side effect profile. We don't know. I can't say this for certain, but probably not gonna affect breast milk much.

[00:19:54] Carl Lanore: [00:19:54] Uh, that's huge right there. That's what I was thinking. It's a dodginess. It's not gonna affect breast.

[00:19:58] Right,

[00:20:00] [00:19:59] Dr. Elizabeth Yurth, MD: [00:19:59] right. So I think you're exactly right. There's a lot of just situational depressions, and we're not going to downplay those because even situation depressions can be devastating to somebody's life. It can ruin marriages, it can ruin families. People still kill themselves. Even if something. If they're depressed for four weeks, sometimes that is such an overwhelming depression.

[00:20:18] So even situational depressions are really detrimental. And our traditional treatments are not designed for situational depressions because it does. It takes too long for them to work. If you, if you just, you know, had some horrible events, you lost a spouse and somebody says, okay, well, three weeks, this will kick in and you'll be better.

[00:20:35] It's not going to do any good. I think this is a really nice option that we can say three, three to four days, you should start feeling better. I have a lot more hope now, right? Cause I can get this out for three days and this is going to work. Right now, the success rate of this drug looks phenomenal as well, and we don't have like a lot of these drugs, we don't have the longterm human trials yet.

[00:20:54] We don't know. But in our experience, it's looking really good. It's looking like most people [00:21:00] are responding very, very well to it without side effects. So worst case, it doesn't work, but you know that when the three or four days you'll have to move on to something else and try something else. And we haven't created a host of side effects, you know, where now those sex drive and, uh, you are, you gained weight as a lot of the drugs do,

[00:21:19] Carl Lanore: [00:21:19] uh, or wait a minute.

[00:21:21] So let me tell you a little short story. People don't know about this. SSRI is, have now been linked to a mitral valve prolapse. Because the, because of the, they, you know, we always think, Oh, well, um, a proton pump inhibitors only affect the stomach. Well, we found that there's proton pumps in the heart and in the brain.

[00:21:39] And now we know people who take these, uh, proton pump inhibitors longterm. They develop, uh, idiopathic, uh, now we know why, but it used to be idiopathic, uh, heart failure and they develop dementia. And so. So here we are again. We're like, well, as SRIs, you know, they only affect the serotonin levels in the brain.

[00:21:56] No, they affect the serotonin levels also in other [00:22:00] things like soft tissue, you, I can always pick a woman out. That's on anti-depression cause right below the navel her belly just pops out like a little light bulb and that's because they've, they've this, there's a study out there that shows us that it destroys the, uh, the, the soft tissue that Coles, the intestines, that like the shock absorber of the intestines.

[00:22:20] They just stretch out and everything just kind of falls pump down upon your diaphragm. Then they end up with urinary tract problems. Right? They can't hold their urine yet because all this stuff is now laying on their bladder. So SSL rise, don't you screw your brain up? They screw a lot of other things up that we're just learning about.

[00:22:38] Now.

[00:22:41] Dr. Elizabeth Yurth, MD: [00:22:41] We know that the sexual dysfunction, both for men and women is huge with SSRS. It's one of the biggest reasons people go off of them. Uh, so you know, and then, so that's creating a whole nother host of disorders for people. Uh, so I think that that, you know, we really don't, we're not looking at the SSRS [00:23:00] or handed out like candy immediate.

[00:23:02] And I, again, I, I, I'm not going to say that they're not. There's people who do very well, and there's people who I know will be writing to you and saying, listen, Prozac saved my life. And I know there's people like that. I have friends who was telling me that it was like, you know, Prozac was huge for me. It stopped my anxiety.

[00:23:16] Something like depression saved my marriage and you know, and so I can't say

[00:23:23] Carl Lanore: [00:23:23] no. I, and I agree. I, I tend to, I'm not, I'm not being a zealot and saying abandon them, but if this may be a better first step before you go, okay, I'll try SSRI first

[00:23:33] Dr. Elizabeth Yurth, MD: [00:23:33] step and let's add to it. This Trek one receptor has a few other things.

[00:23:38] And one of the things we notice that it's connected to is F intro fibrillation. So, so one of the things that's me is also being looked at for is maybe some cardiovascular benefits to it. So that same electric excitability potentially is one of the a fib triggers. And so now they're looking at it as a, a potential remedy for people with a fib.

[00:23:58] So this is going to, [00:24:00] this kind of is going to development some other other realms as well. I think that that. There's not anything you can say about the other drugs that we're using. Here are the other SSRS and things that we can say, Oh, they have all these other benefits. We're not looking at a drug that has potentially better efficacy.

[00:24:17] It definitely works faster. It definitely has a lower side effect profile. It has significant other benefits, including, you know, increasing memory by increasing hippocampal neurogenesis. Increasing potential for cardiac. It with me is to be avoided. So. Sure why not.

[00:24:36] Carl Lanore: [00:24:36] Yeah, no, I agree. So let's get a couple of quotes.

[00:24:38] We're going to get a couple of questions answered here. So, uh, Dawn as sounds like, uh, one for my daughter does, can labs carry it? I have no idea. You have to check on their website. Jeff Clifton wants to know, uh, I, I can tell you that tailor made compounding is making it. Uh, and I, and I got, I got a little conversation I had with dr seeds and I'll mention that when we come [00:25:00] out of the first break.

[00:25:01] Uh, do you have an opinion on transcranial stimulation? I've found the Fisher Wallace device to help. Do you know anything about that? I do.

[00:25:08] Dr. Elizabeth Yurth, MD: [00:25:08] And I do think transcranial stimulation can be quite helpful for people. I do. And it has a low side effect profile as well. It's crazy. It's hard to find a place to do it.

[00:25:16] So there's not a lot of really good centers for it. We do have one here in Boulder that I, and I know they had some good outcomes with it. My success rate, I've referred a lot of people for transcranial stimulation. My success rate has been maybe 50, 50, so it hasn't, but it's been good. Side effect profile is low, I think in general.

[00:25:33] And I picked it for a young person I prefer or an SSRI.

[00:25:37] Carl Lanore: [00:25:37] Right, right. Absolutely. Uh, same, same, uh. Uh, a person in the audience wants to see. She said, no side effects. Sounds good. Are there any, like what if you took a bolus dose? I know if you take it intranasally and I think it's like 200 micrograms, a spray or something, somewhere around that could, could you take too much of this and feel anything bad?

[00:26:00] [00:26:00] Dr. Elizabeth Yurth, MD: [00:26:00] I don't really know that. I mean, they, they, from the rap studies, they have been bred in rats who don't have this receptor, so they're completely devoid of the receptor at all. And they actually did very well. They had no young, they, they, they were, they thrive better than the normal rats. They ate better.

[00:26:16] They better appetites. And with the same thing be true in humans. If we block this receptor completely by taking a massive dose of this and, you know, and so it was completely blocked and that no activity or anything bad happened. Um, I don't know. I don't know the answer.

[00:26:30] Carl Lanore: [00:26:30] Okay, so here's a, a rattling. I'm gonna rattle.

[00:26:33] I'm just going to read this off the text message between bill and I this morning. He said, uh, P E 2228 is a game changer. Fast acting four to five days. Here's what people should know about it. Higher doses, like 800 micrograms, uh, can cause some lethargy. In some people, not everybody. Uh, it's a very interesting peptide, great for depression, but also cognitive enhancer, which Victor  had said that, you know, he has a nootropic effect [00:27:00] and, and bill has some, uh, numbers here, um, at higher, but at higher doses, you can, you can sacrifice some lethargy, very few or aware of this.

[00:27:11] I have been very successful with 400 micrograms a day. Just one spray. So it's 400 micrograms. In one spray from tailor-made. This means a lot more to this peptide since I brought it out and had it synthesize, have also had great success with just 400 micrograms improving cognition and no lethargy. If you stay under 600 micrograms.

[00:27:34] What about injecting it? Do you have to use it at your days? I mean, obviously it's a faster pathway to the brain if you use it intranasally right

[00:27:40] Dr. Elizabeth Yurth, MD: [00:27:40] there. Intranasally the research has shown is it works better intranasally than injected. I do think you get affected that you need a higher dose. Um, I, another tailor may recommend the dosing being being twice what dr  says.

[00:27:52] 400 twice or 400. Or two sprays, so 400 in each spray. Um, but I, I, I certainly trust [00:28:00] his, his experience with it since it's relatively new.

[00:28:02] Carl Lanore: [00:28:02] There's a lot and everybody has different tolerances to this, right? Somebody, somebody may take 400 and feel lethargy. So what, what does that mean? I think you've got to experiment with it

[00:28:10] Dr. Elizabeth Yurth, MD: [00:28:10] and experiment with it and you see, but I think you're not going to hurt yourself.

[00:28:13] I beat a little, it's hard to go. Okay, next time this has about a 23 hour window that's working. And so, which is great. It's a full day. You get a fat from. Uh, but, but it's going to be off in a day. Whatever symptoms you had are going to be gone. So again, I like your SSRI jumping off of it. It's out of your system in 23 hours, uh, you know, and it's perfect for dosing every day.

[00:28:35] Carl Lanore: [00:28:35] Yeah. And she also said that her husband's on Prozac and she didn't know anything about the side effects

[00:28:40] Dr. Elizabeth Yurth, MD: [00:28:40] on Prozac

[00:28:41] Carl Lanore: [00:28:41] and, and, and every, you know what. When it comes to pharmaceutical drugs, you know, this is true of just about everything except peptides. I gotta be honest with you. And that's because peptides are there.

[00:28:52] They're common to the body. The body recognizes them, knows what to do with them, and they know what to do once they're inside of you. Um, [00:29:00] so with that level of intelligence, w when we have protein peptides, we're dealing with, it's a big game changer because most pharmaceuticals, if not all, pharmaceuticals, have some unwanted effects.

[00:29:11] Uh, and, and they sell them anyway. And you know, anytime you listen to a commercial for a pharma drug, the first, you know, 41st 15 seconds, or about the drug and the last 45 seconds, or about all the harm that the drug could do to you. Right? I mean, when you think about that for a second, that's actually really scary.

[00:29:29] Like that's the standard. That's okay. If it hurts you.

[00:29:33] Dr. Elizabeth Yurth, MD: [00:29:33] Right? It's just safe. Except it's accepted that that's, you know, that drugs have these bad sides too. And that's what, so that is what's so cool about peptides, right? They're very unique acting. They work in very specific places and they're fast acting.

[00:29:45] So you don't have these long lingering downstream effects that these drugs have. I mean, these drugs get metabolized. Everybody metabolizes them differently. So you put somebody on, that's why these SSRI is potentially have very different effects in one person than another is because of how you're metabolizing them.

[00:30:00] [00:30:00] Carl Lanore: [00:30:00] So, so, uh, she has a daughter that's also on Zoloft. So if someone was going to, if someone came to you and said, I've been on Zoloft for. Five years now and I want to get off Zoloft and I want to try this. Would you introduce this first? Would you send them to titrate their dose down to nothing and start with a tabula rasa?

[00:30:20] How would, how would you do it?

[00:30:22] Dr. Elizabeth Yurth, MD: [00:30:22] I wouldn't really hit nationally, so really this is, this is our, I do work on, this. Receptors aren't working on this truck receptor, and so whether it's you have to wean off of them is because of this by bite. Go ahead. Initiating. The P 2028 you can probably actually wean very rapidly off of the Zoloft, and so you don't have to wait two weeks

[00:30:41] Carl Lanore: [00:30:41] off.

[00:30:42] No,

[00:30:43] Dr. Elizabeth Yurth, MD: [00:30:43] I would initiate it right at the same time and I would, I would pretty rapidly wean off of the antidepressants. Depressant. I mean, because we really are working on some of the same receptor, we really shouldn't have as many issues.

[00:30:54] Carl Lanore: [00:30:54] Right? I want to take a quick commercial break. When we come back, I want to talk about the rodent model [00:31:00] study.

[00:31:00] Uh, that was in a PLO S one. Uh, I have some slides. I want to talk about diet. We have a lot more to talk about this. And so if you're listening to Su-Preme radio for the very first time, if you came because of this show. Please visit the website, superhuman radio.net. Uh, we have an audio podcast of every show just to where we have a Facebook live, a episode of every show.

[00:31:22] Share the show around, uh, because really the goal of this show is to help people empower themselves to get themselves off of drugs, make themselves healthy and live a strong and longer life. Uh, we're going to take a quick commercial break, pay some bills. We'll be right back. This is the superhuman channel evolution just got kicked up a notch.

[00:31:47] Welcome back. And before we get back into the show, I have to ask my audience to pay attention to what I'm about to say. I didn't, Fran, I didn't plan this out. I just learned about it this morning and I'm going to be talking about it all week. So we love [00:32:00] peptides, right? And we love the freedom that peptides give us to get off of the pharmaceutical bandwagon.

[00:32:07] Uh, but of course, the pharmaceutical industry doesn't like peptides. Uh, and why should they? Because literally people are getting fixed instead of taking things that just mask symptoms. So, uh, there was, uh, a bill passed in 2009, uh, that speaks to biologics and biosimilars. And, uh, recently it was amended, uh, end of last year.

[00:32:32] And this is supposed to go into, into into place in March. So if you know how to reach your Congressman Monday, I'll have a better job. I'll have a link. People can click send that email. I promise you we'll get this done. But right now, the FDA wants to enforce it starting in March, that any peptide that's already being made by a pharmaceutical company, you cannot buy.

[00:32:59] The [00:33:00] generic from a compounding pharmacist any longer. This is going to take a lot of money. So here's what the pharmaceutical needs doing. They don't like peptide, but they thinking, okay, great. We'll leverage all of your efforts out there. All the people that are talking about them, all the people that are using them, and we're going to just go to put ourselves in the middle.

[00:33:15] We're going to make money. So, so things like, um. Uh, uh, ARA  also known as submit a tide, submit a tide was first synthesized by a private company, a pharmaceutical company. So of course they want you to buy it from them. They don't want you to buy it from tailor made or any other, any other synthesizer on the planet, because basically they're not getting their money for it.

[00:33:39] So basically the FDA has a place where you can go if you, if you search biosimilars questions and answers regarding implementation of biologic price competition and innovation act of 2009 so what they're basically doing is. Anything that you can buy from a pharmaceutical company when it comes to a [00:34:00] peptide, this is insulin.

[00:34:01] This is HCG. This is your CJC 1295 all that stuff, if it's being made right now by a pharmaceutical company, if it's been invested in, is synthesize first and they stuck their flag in at first, even though it naturally occurs in many cases in your own body. They're going to want you to pay the higher price for it.

[00:34:21] And this is really BS. This is what they do. This is exactly what Congress and everybody is supposed to be working on, you know, lowering the prices of pharmaceutical drugs. And meanwhile, here you go. Pharmaceutical industry, trying to just intervene in an industry that they have no place in and get in the way of people accessing these things and more importantly, getting in deeper into your pocket.

[00:34:42] So you need to. Pay attention to this all week. I'm going to be talking about it. We need to start contacting our Congress people and we need to say, look, I currently use peptides prescribed by my doctor and a co compounding pharmacist makes it for me. And what you're going to do is you're going to drive the price price up.

[00:34:58] You're going to drive the [00:35:00] access to this stuff down. You better not vote for it. You better, you better get this thing taken out cause they, they closed the deal on this like at midnight, December 25th and some budget deal Christmas Eve or Christmas night. So this is what the government is famous for doing.

[00:35:16] They see an opportunity they want, they want to get in the middle of it and make money on it. So that'll leave people alone. All right.

[00:35:23] Dr. Elizabeth Yurth, MD: [00:35:23] After that. And I really encourage your listeners to get involved here because this isn't the end for me. It's devastating. Have personally, I have a lot of these, these that I use myself I want to access to, but I, my patients, for instance, I literally Tyler, besides a peptide to really help you are borderline diabetic.

[00:35:37] It helps with immune function. It's amazingly beneficial. Uh, and I have a lot of patients have had a huge benefit from it. If once that goes off the Mark, we can't get it anymore. Starting in March. To get the pharmaceutical, which will not be paid for by their insurance because they don't meet the criteria would cost them $1,000 a month.

[00:35:56] Um, you know, and so it's going to be cost prohibited and I'll have to take [00:36:00] all of them off of it, and their blood sugars will go through the roof again, and their immune function will go awry again. Uh, and it's just the farm school industry trying to make more money.

[00:36:08] Carl Lanore: [00:36:08] This is so horrible. This is so typical.

[00:36:11] It's so . They like parasites. They see somebody doing good over there and they want to go and get, you know, get well, let me get some of their hard work and make money on it. That's exactly what this is. That's exactly what this is. Um, so now I gotta answer this question to Dawn. Dawn, this is a drug. Uh, you can't order it like a, you can vitamin C and trust me, if vitamin C was being released today, the FDA would tell you the same thing.

[00:36:35] Oh, you can't buy it. Um. So what you have to do is you have to go to international peptide society, which is peptide society.org find a doctor in your area, contact them and they can prescribe it for you. And then TaylorMade pharmacy. And uh, right here in my home state, Hodgkin's, uh, Hodgkin's mill, that's what Abraham Lincoln was born in.

[00:36:55] Nicholasville, Kentucky can synthesize it and fill your [00:37:00] prescription. So that's how you do this. If this is interesting to you, and if your doctor doesn't know anything about this, there's two things you can do. You can reach out to dr earth on her website, uh, Volvo longevity.com, and she can treat you, uh, or you, eh, which is why I was saying, go find a new doctor or help your doctor become educated about peptides and tell them to go to peptide society.org and sign up to be trained to prescribe, uh, these peptides.

[00:37:26] It's very, very simple, but you can't just buy it online. This is, this is, this is not vitamin C

[00:37:31] Dr. Elizabeth Yurth, MD: [00:37:31] where we're trying to educate doctors. I fortunate, unfortunately, unfortunately. Carl's out there educating all of you. And that's, you know, you guys are usually a lot more open than physicians are to learning.

[00:37:41] And so like, you know, kudos to Carl because you have to, you guys have to go and be the, you know, the force here because you know. If enough people get out there, the force, your doctor has to start listening or we hope so. We, I mean, I'm, I'm on faculty for national baptized society. We're trying to train physicians, but the traditional physician doesn't know much about peptides [00:38:00] and they're pretty, uh, they're might have a closed mind.

[00:38:03] So, yeah, I encourage you, you're more than welcome to come to our website. We have patients all over the country, even out of the country. Um, and we can, not in every state, not every state, but a lot of States we can help out.

[00:38:14] Carl Lanore: [00:38:14] She's in Colorado. She's, I'm in Colorado, I'll go to her psych. There you go. You can actually go see you in person and you're a lucky person.

[00:38:22] Yeah. So, uh, and I mentioned this guy earlier. Uh, Victor. He said, my first day on PE 2228 with one spray definitely had a nootropic effect. Uplifted my mood two to three days in. I have used two sprays so far. Uh, so far it's lifted me up out of my depression feeling normal. Uh, and good today. No impending sense of doom.

[00:38:46] What she told me, he's like, I wake up with this feeling. He says, I take my nasal spray and I can feel it like literally going away. Um, tomorrow is day four, I can, uh, post, uh, I can, I can people post it. He'll keep people putting people posting. I'm sorry, I can't [00:39:00] read a, I also noticed an improvement in my sleep.

[00:39:03] You say improve sleep to anybody in the United States. They're like, where can I get it? I mean, really, I'm, I'm there. I'm there.

[00:39:11] Dr. Elizabeth Yurth, MD: [00:39:11] Thanks for giving us the info Victor info, Victor. Cause it's really nice to hear somebody who has, who has some first hand experience with it. Since we don't have that many people, you know, we have, we certainly have a few people that had similar effects.

[00:39:21] I'm anxious to actually try it on some of my people who have some early memory stuff. Uh, you know, some mild cognitive impairment, early memory stuff and see if they get some improvement. So I'm happy to hear you felt that improvement. You said that nootropic effects right away. Maybe we can replace all the kids taking Adderall.

[00:39:39] Carl Lanore: [00:39:39] Yeah. And, and, uh, Dawn, last thing I'm going to mention, she just said for me to post your website, it's right there under her name, right below dr Elizabeth , MD. You see Boulder longevity.com so you can, you can reach out to her through the website and you can talk to her. So let's get back on task here. So this slide that I've been using, uh, I'm going to put it up and you and I are going to [00:40:00] disappear for a second.

[00:40:01] This is a very interesting slide that came from a. A rodent study where they actually created depression resistant rodents. Talk about this using using a a, were they using spade or were they using a PE 2228.

[00:40:13] Dr. Elizabeth Yurth, MD: [00:40:13] Well, let's say it was what stayed in, um, you know, and, and again, his Baden spin works well. It's just too short acting.

[00:40:19] So, so on the, on the left there a physiologic conditions. This is actually a mouse that was bred without the Trek one receptor. And they did choose these two kind of brutal techniques to see if mice were depressed. Uh, but they, these nice, it didn't have the Trek one receptor. They, they were not depressed.

[00:40:38] They could starve them for days and they would still anxiously, you know,

[00:40:42] Carl Lanore: [00:40:42] vote for food. Hey, I'm starving. This is so cool.

[00:40:46] Dr. Elizabeth Yurth, MD: [00:40:46] Just, or if there's, there was all these kind of, they put them in this VAT of water and, and how long they could try. Why, if you, if you're depressed young, if any of us are drowning, we eventually get depressed and these mice would just keep

[00:41:00] [00:40:59] Tried and away, they just, you know, they, they thought, Oh, this is okay. I'll just keep going. Whereas normal mice kind of just burn out and say, screw it, and they, they would, you know, sort of try and maybe stay afloat for awhile, but eventually drown I'm be, is with, with a normal mouse who has fade in. Right, right.

[00:41:18] But they also upregulated. It's been by injecting spading in, and you can see they actually created a similar phenomena of depression resistant mouse. But also they, they, um, they increased the mouses, the mice, his ability to learn as well. So they increased their, again, this sort of memory, the cognition.

[00:41:39] So we sort of have very similar effects that we, you know, when we, that we could create. And Sergeant by injecting spade Nin. So we're going to see the same effect with this peptide except it's going to be longer acting.

[00:41:50] Carl Lanore: [00:41:50] So do you think that, uh, there are some people out there who maybe produce more Spaten than others and that's why they tend to be much more optimistic about [00:42:00] life?

[00:42:00] I wonder

[00:42:01] Dr. Elizabeth Yurth, MD: [00:42:01] if it's probably genetic difference in the receptors. I wonder if it's more spading or difference in the receptors. Cause we do know now we've identified I think four different snips, single nucleotide polymorphisms. Of people who have abnormal receptors that are much more depressed and much more recalcitrant to treatment.

[00:42:19] So we know that there's a genetic identifiable group of people who have abnormal Trek receptors and have significant depression and significant depression that does not respond to traditional treatment. So that group, we hope will be treated by this. Is there a group that is unusually happy? Uh. I wonder if they maybe have, if it's less the speed and production, but it might be, I don't know.

[00:42:43] more of a difference in just receptor number. Maybe they have fewer Trek one receptors.

[00:42:49] Carl Lanore: [00:42:49] I do

[00:42:49] Dr. Elizabeth Yurth, MD: [00:42:49] wonder if you know, there's this whole familial trends. One of the things I'll look at with genetics and I look at people is this trend towards atrial fibrillation. I know a whole families where everybody [00:43:00] has had atrial fibrillation.

[00:43:03] I'm from ventral fibrillation is also linked. This receptor. Be interesting to go back and look at that. Family also had more instances of depression and things like

[00:43:08] Carl Lanore: [00:43:08] that as well. Interesting. And you know, I developed a AFib when I was depressed. It's funny you should say this because I had to go. That's when I, that's when I had to go for my tricep surgery and I had to go get cleared for surgery.

[00:43:19] And the doctor said, uh, the girl said, Oh, you get, you're going up to your cardiologist. I said, why? She said, well, you've got a AFib. I just, I do. And she said yes. And I went, and they, you know, they did the echo and they did all this other stuff. He be like, no, your heart's fine. But, but he said, but you do have a AFib.

[00:43:33] And the girls tried to convince me to take warfarin. You know what? It's like trying to convince me to take warfarin. She even tried, you know, if you and my brother, I wouldn't let you leave here without a prescription for warfarin. I said, Oh, that's sweet. I said, but I'm not your brother. And I left warfarin.

[00:43:50] Um, so Jeff Clifton wants to know if this is also used for bipolar depression. Is there such a thing as bipolar depression? I mean, I thought it was bipolar disorder, [00:44:00] uh, which is a combination of depression and mania, right?

[00:44:04] Dr. Elizabeth Yurth, MD: [00:44:04] Well, and so there are bipolar people who tend more to depression. And those people do vary.

[00:44:10] They don't do so well with and depresses typically. So when you put somebody with more of a bipolar depressive episode. They need. You always have to add mood stabilizing drugs in as well, because you just put them antidepressant. They tend to get very anxious. Uh, and um, so this actually should, because it's working on the piece, whereas the antidepressants.

[00:44:31] Don't help the anxiety piece, and that's what happens to those people. This should actually help that. So it should work without having to put people on the, the Lamictal or other mood stabilizing drugs along with it. I think that we don't, I, I'm not going to say that with certainty because I haven't treated the bipolar people with this yet, but I know a lot of people, probably young people who are in that, as you described, have more of a, of a, of a bipolar depression, and when you put them on antidepressants, they very well do very poorly unless you add Lamictal or lithium or something like that.

[00:44:59] I. [00:45:00] I do think there's a place for maybe in people like that adding something like CVBs because we know conditioned noise can be really helpful to that group, but people too. So you might consider doing something with CBDs along with this peptide that might be really helpful

[00:45:13] Carl Lanore: [00:45:13] or just smoke weed. Um, but anyway, I know you're a doctor.

[00:45:17] You didn't say that Iceland, but you live in a state where it's okay. So I don't have to cover for you. I don't have to cover for you. So, so, um. There is a, uh, about, uh, 17 or 20% of men who suffer from erectile dysfunction who don't get any, uh, benefits from a PDE five inhibitors tend to have, um, performance anxiety.

[00:45:42] And they do better, like when they've had a few drinks or if they take a a volume or something like that. I got to believe that this could work for them as well as as a monotherapy. If they don't need PD fives, if they can get erection, but the problem is they get nervous about sex, this might actually benefit them.

[00:45:59] Dr. Elizabeth Yurth, MD: [00:45:59] I think that'd be [00:46:00] interesting to look at too. I mean, it's certainly, I think it might be really, because it definitely has that kind of rapid effect on anxiety and introvert, maybe in that group, you know, and maybe two of those people who get very, very nervous with presentations or exam nervous

[00:46:13] Carl Lanore: [00:46:13] instead of taking beta blockers.

[00:46:14] Yeah.

[00:46:18] Dr. Elizabeth Yurth, MD: [00:46:18] So you think about that same thing. Why did they book beta blockers? We talked about this whole neural excitability and why this is related to cardiac functions. So beta blockers, which slow down your heart, but they also help with your anxiety. Nikki feel you'll be able to perform a little bit better.

[00:46:31] So this might be a very interesting,

[00:46:32] Carl Lanore: [00:46:32] but beta blockers actually lead to depression. If you take them longterm, these people become, because your body needs that a adrenergic boost, right?

[00:46:42] Dr. Elizabeth Yurth, MD: [00:46:42] Right. Yeah. Beta blockers also make people feel, certainly nothing you'd want to do long term. They make you feel crappy.

[00:46:46] They, they'd give it exercise performance.

[00:46:48] Carl Lanore: [00:46:48] So I look at my face, I go, that's ugly. That doesn't taste good. Uh. Yeah. So let's, let's, let's  a couple of things that we're going to talk about now. One of them, um, [00:47:00] I originally wasn't prepared to talk about, but since we've talked about erectile dysfunction and earlier stuff, I'm gonna mention something towards the end of the show.

[00:47:08] Uh, but let's talk about diet and stop for a second. I'm going to put this slide up here. This was from your recent presentation on this peptide, and you show that vegetarians suffer from a greater incidence of depressive disorders and omnivores, huh?

[00:47:23] Dr. Elizabeth Yurth, MD: [00:47:23] So this was an interesting study. Um, and the people are gonna say, Oh, that's because they were lacking be 12 and so be 12.

[00:47:32] But they actually accounted for that. They looked at B12 levels, they looked at nutrient levels, so it was independent of nutrient levels like currency and B12. So they actually, they sort of took all that off the table. Cause my first this, I was like, well that's stupid because the veterinarians oftentimes have deficiencies and so they, they.

[00:47:51] They took that off the table and there still was a big difference in terms of depression in people who had, who were vegetarians versus non vegetarians. Um, [00:48:00] and as you can see, actually the, you know, the, the group that did the best was the more carnivore people. I don't know exactly what I sound

[00:48:08] Carl Lanore: [00:48:08] like. I would, I would call them an omnivore.

[00:48:11] Right? You're not avoiding wheat, you're not avoiding vegetables. You kind of eating every that, that to me, I mean, I eat meat and vegetables. Yeah. Yeah. Right. So are you, are you applying it? Could that be a link between diet and the production of this pep talk? Do you think?

[00:48:28] Dr. Elizabeth Yurth, MD: [00:48:28] Excuse me, don't really know the answer to why are those people, so why is there a difference?

[00:48:32] You know, is it, it might be a difference in fat intake. So you know, this, this, this, uh, receptor is very dependent on having a normal phospholipid membrane to, to act appropriately. If you're very low in fats. As sometimes the vegetarians are eating and what they're eating, they're not eating the same amount of fats as somebody who's eating more meat.

[00:48:52] So, could there be something with that? I don't think I know the answer.

[00:48:55] Carl Lanore: [00:48:55] Well, so, so, so, so, uh, if we just try to look at, at [00:49:00] tangential, uh, maybe coincidences, but maybe not, you know, uh, vegans tent longterm vegans tend to have very, very high brain levels of copper and very, very low levels of zinc. And a lot of people, um.

[00:49:15] Who have been vegans, who will also, uh, dieticians that I've spoken to on the show, uh, have told me that when you first go vegan after like the first two or three weeks of being straight vegan, you kind of get this euphoria. And this euphoria is, makes you feel like, wow man, this vegan diet is really what I needed.

[00:49:38] Cause I just feel so good. And, and, and, and they tell me that this is because as copper levels rise and zinc levels drop brings on the onset of this euphoria, but as it goes longer and longer and longer, it leads to feeling sad all the time. And. In 2013, uh, a psychology today [00:50:00] magazine in December, actually, uh, did an article called, why do vegans suffer from a greater degree of depression than omnivores?

[00:50:10] And so everybody knows this about the vegan diet. Everybody knows that it leads to depression. Or mania in some people, but we really don't know why that is. This, this plausibly could be maybe, maybe there's a link. You know, I tried to look for links cause I understand that potassium role in this. And I tried to look for links, you know, to see what were the precursors, what, what, what turns this on.

[00:50:33] And there was that one thing. Um. Is it's battle in a spotlight or something like that. This is a, Oh, here. It's right here. Yeah. S sorta lit. Right? Spading is a sorrel and derived peptide. What is sorta

[00:50:46] Dr. Elizabeth Yurth, MD: [00:50:46] Lynne

[00:50:49] is, I think the precursor to Spain.

[00:50:53] Carl Lanore: [00:50:53] Right? Okay. But do we know where  comes from? That's part of that whole potassium channel activity. The in the, in this study I read, [00:51:00] I keep coming back to potassium levels. I really, really do. I'm wondering if potassium plays a role. In the development or the production of, uh, let's say  and then the downstream of spades.

[00:51:12] Dr. Elizabeth Yurth, MD: [00:51:12] You'll probably get bill sees in his pathway knowledge. He,

[00:51:16] Carl Lanore: [00:51:16] yeah. So

[00:51:18] Dr. Elizabeth Yurth, MD: [00:51:18] this photographic pathway much. Yeah. I know. I would have to sit and research for a few hours on how those, all those pathways are connecting.

[00:51:25] Carl Lanore: [00:51:25] So, so last slide I want to put up here again from, from your presentation was looking at the Mediterranean diet and how it actually appears to, uh, decrease the risk of depression, right?

[00:51:38] Dr. Elizabeth Yurth, MD: [00:51:38] Yeah. Markedly actually. So these were, they basically put these people on on these, these different diets, and this was 10,000 adults who were not were screening, had no depression, and then they put them on these sort of different types of diets with the. A very low type Metreon dye, so very low intake of fruits and nuts and fats, healthy fats, [00:52:00] and then a very significant increase in depression over over.

[00:52:03] They followed for four years, so I don't know how well controlled they can keep till I die for that, but versus the group who had a very high high intake of those, he seems they got to the highest seem

[00:52:14] Carl Lanore: [00:52:14] to bump up a curve to bump up a little bit. Yeah.

[00:52:17] Dr. Elizabeth Yurth, MD: [00:52:17] Which is interesting. You know, kind of say, well, why, you know, why is that?

[00:52:20] What is the difference there? So, but, but definitely we know that. And again, this is going to come down to, you know, getting good fats in your diet is super, super important. And we know that Mediterranean diet is very healthy and get fast. And I think that, that, that good fat Pease is a big player and maybe this receptor, um, and a lot of sort of our brain chemistry in general.

[00:52:39] So I think that that's something that gets really the collective when we start getting into these, these diets that are sort of eliminating so many of those things.

[00:52:45] Carl Lanore: [00:52:45] I want to take a last commercial break. When we come back, I want to talk about something that I discovered. And I think it's either going to be taken as me being a jerk or being funny, but it's not funny.

[00:52:56] It's real. There's two studies that I just read that, uh, [00:53:00] implicate the presence of not only this peptide, but a kisspeptin in an interesting place. Well, stay tuned. We'll be right back with more superhuman radio. This is the superhuman channel where we use oxygen for the power of good.

[00:53:17] Welcome back. We're going to wrap up the show.  I saved this for the end of the show cause I didn't want to ruin the show by saying anything like this before, but it's true. And I, I texted bill seeds, dr seeds and I, I said, I can't make this stuff up. So, so I got to show you how my ADHD brain works for a second.

[00:53:37] So I did a show not too long ago, last year with Joel green, where we looked at the transgenerational epigenetic effects of things, and we looked at, uh, micro RNA and germ lines in both semen and OVN ovum. And how they, how what you do now influences. Your body's perception of your environment. And so it builds a human prepared to live in that [00:54:00] environment.

[00:54:00] And why it's a bad idea to conceive if you're like deep into Quito cause you, you, your baby's going to be made like with all the thrifty genes. Cause you can't believe that it's coming into a world where this is all you can eat. Uh, so we were talking about all that. And so I was, I had to read a study and preparation, um, and it was called, uh.

[00:54:23] Peptide proteins in a seminal plasma plasma is positively associated with semen quality. The results from the March study and, uh, Chung King China. So that, so I was thinking about that, right, because one of the peptides that's in semen. Is kisspeptin, which we know kisspeptin is being used right now to stop the progression of cancers.

[00:54:47] If there's a lot of stuff going on. Kisspeptin kisspeptin people using kisspeptin to save themselves if he seems to turn off metastasis, blah, blah, blah. So just out of a hunch, I thought, because don't forget, when I [00:55:00] first did this show, the first year I did the show, I talked about a study that was done in 2002 by my old Amata state, university of New York.

[00:55:09] Where they looked at, um, they looked at a D, it was from the department of psychology. They looked at depression, uh, and it was, does semen have antidepressant properties? And they looked at college women college age women who were sexually active, who were using condoms and not using condoms. And they did all this work with them and they scored them.

[00:55:29] And they said women who were coming directly in contact with semen, no matter how they obtained it. What, what the, like the risk and the development of, of, of, uh, of depression was so stuffy, statistically significant that they, they said, you know, something about semen is, and they, and so of course they said the testosterone cause that, you know, were, man, everything's about testosterone.

[00:55:53] So I went back and looked at that other study. Well, not just kisspeptin isn't semen. But so is Spaten. [00:56:00] So there may

[00:56:01] Dr. Elizabeth Yurth, MD: [00:56:01] be places you find lots of statins. The prostate gland is tons of in the prostate, but I think brain, heart, kidney, and prostate are like the highest amount of spades

[00:56:12] Carl Lanore: [00:56:12] and anything I can do to get people to have more sex.

[00:56:15] I want to be, when I die, I want the Pope to make me the patron Saint of sexual activity. Because sex saves lives, the more sex you have, the longer you live, the healthy your B. So naturally I text this to Alisa right away and then I texted and I said. I will, I can take your HSA credit card. I said, if you want, she didn't respond then she's not gonna respond cause she's going to say she's going to tell me it's a BS, but okay.

[00:56:40] Dr. Elizabeth Yurth, MD: [00:56:40] Cheaper and then dying

[00:56:42] Carl Lanore: [00:56:42] and it's more fun to me. It's more fun to make two. I mean, you make it at home. It's good. It's all natural. You make it at home. So there you go, guys tell you why. Oh, your girlfriend.

[00:56:54] Dr. Elizabeth Yurth, MD: [00:56:54] She says

[00:56:55] Carl Lanore: [00:56:55] if she says she's depressed, they look, you know, I, I don't mind doing it. I don't mind doing [00:57:00] it for you.

[00:57:00] I'll, I'll do it. I'll take a bullet. I can help you get rid of that depression and it's scientifically proven, so there you go. That's it. That's all I got for today. I'm sorry to do that with you on the air. I'm sorry, but it's true. It's true. I can't make this stuff up. I told bill like, you can't make this stuff up.

[00:57:17] I said, no. There you go. What else did we miss? Anything on this discussion, dr earth?

[00:57:22] Dr. Elizabeth Yurth, MD: [00:57:22] And I think we got, I just, I want to kind of close with that. Kudos to you, Carl, for educating all you guys. Thank you for listening to him because unfortunately you guys are going to be the force that starts changing medicine.

[00:57:34] It's not going to be the physicians. You can't rely on the, you have to on smart people like Carl. To kind of come in and bring people who will, who will give you this new stuff. Um, this is going to be a, another cool kind of landmark thing that we can use and, and hopefully cure a lot of people and help a lot of people without doing a lot of damage.

[00:57:51] So if we are going to you, one of the things we've decided is much like what you're doing, Carlos, we want people to. Do you go and get your own labs and your look at your own labs [00:58:00] and interpret your own labs? And once we realize that people need to learn how to do that themselves, we're actually within border longevity Institute, starting a human optimization Academy kind.

[00:58:08] Of course, there's gonna be just a one day seminar you can come to, you can fly here where we actually teach you how to look at your complete blood count, your sat, your chemistry panel, all the little hidden things that your doctors even tell you. In there that will help you and what you can do this or change some of those factors for health, you know, sort of health span.

[00:58:24] Cause we were, we're realizing that you guys are kind of going to be the change in the face of medicine. It's not going to be the physicians. If we rate for the physicians to do it, it's going to be a who knows when. So I encourage you guys to keep learning, um, and, and keep doing this. And because I, I, I, I've lost faith in the doctors to do it.

[00:58:41] Carl Lanore: [00:58:41] Bought everything gets checked, everything gets changed in the free market by demand. Right? And, and we, and we, the public, we are the ones that set, set the demand. So yes, you're right. And I, by the way, that is so cool. So people can come to your facility for, what is it? What does this clinic cost to get called?

[00:58:59] Again,

[00:58:59] Dr. Elizabeth Yurth, MD: [00:58:59] we're going [00:59:00] to be starting a course called human optimization Academy. And the first one, we're going to go, well, this is online eventually, but we're right now, we're having people come, we're going to spend an entire day. It's going to be basically you'll get, you'll go get your blood drawn wherever you are, and then you'll come here.

[00:59:13] It's been entire day from, from. Seven in the morning till five and we, we kind of teach you, how do you look at a CBC? What does a good white count versus an Evelyn, what does that differential mean? Look at your complete metabolic panel so you understand what the kidney functions are. The liver functions are, cause your doctor only looks for those little reds.

[00:59:29] Oh, this is off. You need to know how to look at those for optimal values. And if they're not optimal, how you can change them. In fact, we can even sort of teach people how to look at those numbers and put it together into a kind of a, a little algorithm that will tell you how long you have to live and then how can you change that?

[00:59:44] I mean like the size of your cells is really important. People don't know that. Your doctor doesn't tell you that. So simple little things like that's where I kind of teach you how to be in one sense. And we want to teach patients to be the drivers of their healthcare instead of relying on their doctors to do it.

[00:59:58] Not going to say, right, your doctor [01:00:00] Addis situation, but you'll go with them and communicate and say, listen. This value isn't where I want it to be. And you know, and then we're going to give you tools to change that. So we're gonna start with just going through and basic

[01:00:10] Carl Lanore: [01:00:10] metabolic panel that is so big.

[01:00:13] And I, so it's funny because it also comes in handy when you understand the metrics and why these levels are where they are. Because there's a. There are pathological changes in their physiological changes, and sometimes they look exactly the same in bloodwork. And case in point, I recently had blood work done and my pro BNP was 490 now, for those of you who don't know what that is, it's actually a brain, a Nutro, a nutrient, what is it called?

[01:00:44] NUTRIC peptide. But. It's produced by the left ventricle of the heart when the left ventricle is working really hard. Well, in the average slothful person who's sitting on their ass all day long, when their probian P goes up, it means heart failure is coming. [01:01:00] But on a guy like me who lives heavyweight and does this stuff I do, I went and had my blood work done.

[01:01:05] And, and my guy called me and says, dude, he goes, you've got heart failure. I said, I don't have heart failure. I could sprint. I said, what are you talking about? And then when I knew, I said, let me take a couple of days off from the gym. And sure enough, my probian P was down again. So when you understand this stuff, you actually can give input to your doctor and go, no, no, I don't think you're right about that.

[01:01:24] Dr. Elizabeth Yurth, MD: [01:01:24] That's right. That's why you go get your own blood work done and look at it. And we will all the time come to us with these last Nagel. My doctor said this was normal. And you know, and what does that mean? And it means nothing. So you need to know how to interpret those values, what it means, how to make changes in them.

[01:01:40] And we'll show you how each of those little values, but up or down a little bit, will make a huge change in kind of your health span and your longevity of being a healthy person. It's very cool stuff. It's all these hidden little things that are in your blood that nobody talks to you about

[01:01:54] Carl Lanore: [01:01:54] educating.

[01:01:55] Yeah, the best consumers and educated consumer. If you get educated

[01:02:00] [01:01:59] Dr. Elizabeth Yurth, MD: [01:01:59] longevity.com site and then click over to the human optimization Academy, the first course is going to be 20 peoples. We expect to kind of fill up. That's the, hopefully we'll start getting the, we just want you guys to be able to dictate your care a little bit better.

[01:02:11] Carl Lanore: [01:02:11] Yeah. Very, very cool. That's awesome. All right, well, it's been always a pleasure to spend time with you. I hope you have a wonderful weekend. Great. I would imagine people are going to start reaching out to you that have depression and want to know how to get this peptide, so be prepared. 

[01:02:25] Dr. Elizabeth Yurth, MD: [01:02:25] really appreciate it.

[01:02:26] Carl Lanore: [01:02:26] I'll talk to you soon and we'll see everybody Monday. Uh, we have a great open season on men. Monday we're going to be talking about, and this is actually for women who are breadwinners too. We're going to be talking about alimony. There are some real problems with alimony and the way divorce occurs today and family courts, and we're going to address that, uh, uniquely from a man's perspective.

[01:02:45] But there are a lot of women out there who are breadwinners need to hear this

[01:02:48] Dr. Elizabeth Yurth, MD: [01:02:48] show. It shows I'm not listening to that show.

[01:02:52] Carl Lanore: [01:02:52] Do you know. Real quick cause I know you, you have things to do. But I was going to launch that show, uh, nine years ago [01:03:00] because I had gone through a horrible divorce and I wa I wanted to be like Charlie sheen.

[01:03:04] You don't pay women, you pay women to leave. You don't pay them to show up. And I thought, you know what? I will never ever be in a relationship again. This is BS, blah, blah, blah. And open season on men was going to launch as a standalone show almost nine and a half years ago. And then I fell in love with Elisa.

[01:03:22] And I couldn't be angry anymore. I was like, well, now it's not about me being angry. I'm more interested in empowering men. Women have done a wonderful job. We need to tear a page out of their books. Women have done a wonderful job of empowering themselves, mobilizing opinions, getting things done, and guys sit back and we just bitch, Oh yeah, this, this.

[01:03:43] It's time for guys to start wising up a little bit. So that's the whole goal of that show. That's all it is. Okay. And that's it. Thanks for watching today. Thanks for listening. We'll see everybody next week. Have a good safe weekend. Some music here. [01:04:00]