[00:00:00] Carl Lanore: [00:00:00] Welcome back to another episode of superhuman radio. Today is April 5th, Cinco de Mayo, and we are 48 days into the lockdown, uh, due to covert 19. Pandemic. We have a really great show today, especially in light of the fact that the liquor stores seem to be essential and they remain open during this pandemic.

[00:00:21] But tell you what's not essential, and that's hangovers, and maybe we don't have to have them. Uh, if we imbibe who are going to get into that in a little bit with my guests, Dr. Donald Davis and Joshua Silva and just the moment, but first we have to acknowledge and pay homage to our title sponsor legendary foods.

[00:00:42] Legendary foods is the title sponsor of this show. And I'm proud of that because they make great products. And the reason they're so great is because they have no added sugar, and some have no sugar at all. Uh, they're seasoned nuts, obviously don't have any sugar added, and their nut butters tastes [00:01:00] sweet and decadent like blueberry cinnamon bun.

[00:01:04] Uh, but they have no added sugar at all, and they're fantastic. Good for the kids. Good for you. Great snacks, uh, healthy choices. And let's not forget their tasty pastry, which is a pop tart upgraded. It basically is a toaster pastry, like a pop tart looks like a pop tart, uh, tastes better than a pop tart has nine grams of high quality high leucine protein, less than one gram of sugar.

[00:01:31] These products are great. If you go to eat legendary.com and use code , you'll save 10% off all of your purchases. Uh, check them out and show them some love. And for those of you tuning in, start a watch party right below our screen on Facebook. You will see a, uh. You'll see an image or a button that says, watch party.

[00:01:55] Just click that and have friends of yours joined the show [00:02:00] to learn more. I'm being joined by my guests now, and that is, uh, dr Daryl Davies, uh, and Joshua silver. How are you guys doing?

[00:02:10] Dr. Daryl Davies, PhD: [00:02:10] Well, I was doing pretty good. You made me hungry. It was that little invite from legendary foods.

[00:02:16] Carl Lanore: [00:02:16] Dr Davies. These are good products to eat if you're concerned about consuming too much sugar.

[00:02:20] This company is amazing. The I, the founders of this company are the original founders of quest nutrition. Quest nutrition was sold last year to the company that owns Atkins. Uh, and uh, and now they've started this company and they continue with this mission. Of making a healthy snacks for people.

[00:02:40] Fantastic. You'll love them if you check them out.

[00:02:44] Dr. Daryl Davies, PhD: [00:02:44] They sound really good. I mean, I instantly got hungry for it. I liked that pop tart idea that sounded great for myself and

[00:02:49] Carl Lanore: [00:02:49] my kids, so I take their pop tart. I take two pop tarts and I smear one of their nut butters on it, and then I make a sandwich out of it.

[00:02:56] I've even seen people put ice cream, uh, like, uh, [00:03:00] these, uh, zero sugar ice creams that are out there now and make ice cream sandwich sandwiches out of the, uh, out of the tasty patients. It's out of this world. It's really, and you know, you can't believe, you don't feel like your cheat. You know, you feel like you're cheating, but you're really not because these are actually good for you.

[00:03:15] Dr. Daryl Davies, PhD: [00:03:15] Well, you got me. So I'm going to give him a try.

[00:03:17] Carl Lanore: [00:03:17] Okay, so now let's talk about something a bit more important. I and my audience knows that once in a while I like to empty a few. Negroni's being Italian. I like to drink. I, my grandparents gave me wine with my Postina before I started in school. So, you know, I've been drinking for a long time and it's not something I'm going to give up.

[00:03:35] I, you know, I know the risks of consuming alcohol. I accept those risks. I don't do it frequently, but I don't. I don't lie to myself and say, Oh, alcohol is good for you. Like a lot of people want to convince you, but you guys have actually maybe found a way where it is. It is actually less damaging. Let's talk about the impact of alcohol.

[00:03:54] First of all, uh, w want to start with this doctor Davies, the toll in the [00:04:00] United States from alcohol.

[00:04:02] Dr. Daryl Davies, PhD: [00:04:02] Sure. So, so I'm really glad to have this opportunity call first off, because normally these types of interviews I have are like five minutes, 10 minutes, and we really don't get to talk much about this.

[00:04:12] But you know, we've been hearing so much about Kobe and, and it, it is taking a dire consequence on our, on our economy and our lives and the company. But just look at this first little bullet that you guys showing every year. Alcoholism. Alcohol abuse in this country alone takes about 88,000 lives. Um, it's, it's the third leading cause of preventable deaths in the United States.

[00:04:36] So you can think of the others smoking. Right. And we've actually made some inroads on smoking until unfortunately vaping came along about 10 years ago when the tobacco industry instantly started buying up the, um, vaping apparatus cause they figured out, well this is a good way to, to redo this, but. The same has happened, and we'll talk more about this later on.

[00:04:57] The distillers of America also [00:05:00] in the of the world because they, they make products. They have to sell the products. I enjoy alcohol,

[00:05:04] Carl Lanore: [00:05:04] big money, big money.

[00:05:06] Dr. Daryl Davies, PhD: [00:05:06] I was born and raised in San Pedro, California, which is a good slab in Italian town. There's still lots of good Italian, good Italian friends. We drink lots of, uh, Lamesa wine, for example.

[00:05:17] Um, and, and. That's good. But what happens when you do it an excess? And that's when it starts to cause lots of problems. And we're going to talk more about hangover today that people don't even think of hangovers of disease. And interestingly, I don't want to get hemmed myself, but Germany and the German courts, Supreme court, Germany just recently ruled against the case that, um, accompany selling.

[00:05:42] Um, hangover products, they, they recently ruled that hangover is now considered, they ruled it as a disease in Germany, which is going to make it harder to sell natural products as, um, uh, for treated handle were because cause now you're saying you're treating a disease

[00:06:00] [00:06:00] Carl Lanore: [00:06:00] now, now you're an orphan drug now.

[00:06:02] Um, so, and, and that's a, that's an important distinction because globally. Uh, alcohol consumption contributes to 3 million deaths each year since we're also sensitive to, uh, mortality right now and comorbidities, and we're hearing all of them, people will finally go, wow, you know, we lose 60,000 people a year to the seasonal flu.

[00:06:21] Well, we lose 3 million people a year globally due to alcohol related deaths. That's, that's bizarre.

[00:06:28] Dr. Daryl Davies, PhD: [00:06:28] No, I mean, you know, I sometimes when I preface some like conversations for example, cause another area I'm interested in forces, I do neurodegenerative diseases and that includes Alzheimer's. And so actually we're working on DHL with my colleague, Dr.

[00:06:41] Jane Lang at USC to develop DHL for Alzheimer's. And that's actually our, our, one of our really. Great interest because we've shown really promising outcome. Um, but I preface it right away when we talk about the cost of, to, uh, human life and societal costs. Um, when I go out to [00:07:00] these Alzheimer's talks and I stand up and say, you know, that's really terrible the way that's going to cost us.

[00:07:05] In 20 years, 10 years from now, it's going to cost the country. But let me tell you, I'll call it some cost that right now, and no one's talking about it, or very few. I mean, when I go to an alcohol meeting, we all talk about it, but it's one of the smaller institutes was smallest funded, uh, NIH institutes.

[00:07:21] It's everyone enjoys drinking. Um, but because of the stigma attached to alcoholism, we just keep ignoring. The side effects and the consequences we have not faced up to to the fact that this is a serious disease and it has to be conserved as such.

[00:07:39] Carl Lanore: [00:07:39] So Joshua, the CDC estimates that of costs. Taxpayers in this country, $249 billion a year because of excessive drinking.

[00:07:49] And it's basically considered, you know, it's, it's, it's a social thing. It's like, it's not looked down upon. In fact, people who refrain from drinking are looked at pawn like as though, you know, what are you up [00:08:00] to? I don't, I remember that saying, never trust a man who doesn't drink. Yep.

[00:08:05] Joshua Silva: [00:08:05] Yeah. So, yeah, in the United States, there's a huge cultural acceptance of alcohol consumption.

[00:08:11] It's very much the associated with socializing. So yeah, there is a stigma for individuals where at a party they aren't consuming alcohol. The rest of the group, and still, you know, it seems to be, have a different effect. Um, but yeah, when it comes to the disease relation, there's also that kind of stigma of trying to relate it towards those aspects of alcohol use disorder, alcohol, liver disease.

[00:08:29] Um, but yeah, you're correct. It's, it's definitely something that we're, the accepted for social aspects.

[00:08:34] Carl Lanore: [00:08:34] So this molecule that you studied, talk about the research, first of all, what preceded this that made you get on this trail. The first place. And either one of you, whoever wants to answer that, can do this.

[00:08:45] Dr. Daryl Davies, PhD: [00:08:45] So let me, let me preface this, that I've, I've been at NIH and I, AAA national Institute of alcohol abuse and alcoholism, a funded researcher for the past 15, 20 years, I guess. Um, and I was trained as [00:09:00] a graduate student, uh, as a second career. Um, so for some of your audience, realize that I did 17 years in the retail industry, grocery industry, which is a really hard industry to make a profit in.

[00:09:11] I mean, it's. I mean, as, as a worker, it's, it's a, you learn a lot about business when you're in the retail. And so I, I brought that business background with me into the, um, my training as a graduate student. And then I, I got interested in alcohol research and, but the majority of my focus for the last 20 years was developing first, uh, developing our understanding targets for alcohol action, how, what are the targets in the brain?

[00:09:40] And then the last 10 years. Trying to repurpose or develop pharmaceuticals to help treat alcoholism. Um, but that's a long, long path to develop a new molecule from discovery to market. 10, 15 years, they had dollars or more in some cases. And big pharma is not interested, uh, has not shown a lot of [00:10:00] interest for alcoholism.

[00:10:01] About. Eight, nine years ago, one of my colleagues at UCLA, Dr. Richard Olson and a colleague of one of his coworkers called scientists, his lab, dr Jane Wang and I met at an RSA, a how fall meeting, and we started talking about she, she did her training, original training in China. She's been in the United States for about 20 years.

[00:10:23] Um, she did her, um. Her MD training in China. Her PhD training in Japan has a very keen instinct on natural products, these Chinese traditional medicines. And we started looking at the, and she'd been working on these for maybe 15 years, and I got really interested because these are natural products, and you read the Chinese literature and this product is at this part of this app, blah, blah, blah.

[00:10:46] All these great things. But. It's a lot of focus, focus. It's a lot of original Chinese literature. You actually want your village and your village person that would mix these, these spices together.

[00:11:00] [00:11:00] Carl Lanore: [00:11:00] There was no standardization. You know, that they identified these, uh. Different categories of plant sources by, by the way, they look, they had no idea what the active ingredients were, but they thought that they worked and there was some effect.

[00:11:13] And sometimes it could be placebo or no CBO. That's, that's actually doing it right. But it's

[00:11:19] Dr. Daryl Davies, PhD: [00:11:19] a lot, lots of different explanations, and so I put my science hat on. I'm a scientist and scientists by nature, those of us that are in the discovery side are just naturally inquisitive. We asked, well, why does it work?

[00:11:33] Why? Why is this literature 500 years of literature? Is this all BS? It's, it's hard to believe that you'd have 500 years. Of this literature, and there'd be no, no nothing to it. And there's an, it talks about liver protective effects. We'll get, we'll talk about morning recovery later in the show, but, um.

[00:11:53] There was, there was all this indication of this dihydro mycelium, which is a flat, annoyed, um, and having this [00:12:00] beneficial effect to reduce alcohol intake. That's how I first got involved with it. And more for the CNS, talking about the brain, it reduces urge. It reduces, uh, alcohol intake, um, but it had other properties, and one of those properties was liver.

[00:12:13] It was. Reported to have some liver protective effects, and I was saying to myself, you know this, how does this.  there's lots of flavonoids out there and lots of people have looked at flat much. How could it be that this drug, that this molecule does this, it does that. It's just, you know, what's going on.

[00:12:32] And so I, so I put my scientist hat on and then, uh, Josh came to join my lab as a PhD student. He's a very, very bright, hardworking, uh, PhD student, and he had an interest in liver. I wasn't a liberal person. I must see an S person. Um, and he had this interest in liver and we got together with my colleague, uh, Dr.

[00:12:55] Lang at USC school of pharmacy that'll plug my school. That's where I work. I get paid to [00:13:00] work here, um, or I did before Cola. Now we're doing well, let's get back soon,

[00:13:07] Carl Lanore: [00:13:07] but Hey, we can still drink and test this stuff. You know what I mean?

[00:13:13] Dr. Daryl Davies, PhD: [00:13:13] Well, I started to get interested in liver and I said, okay, we know we, we partnered with this company, this more labs that developed this morning recovery using the original formulation actually came from Jane, uh, was James' formulation. And I think they've modified it since then, but I said, you know what, they can sell it as a, as a hangover remedy.

[00:13:33] And there's lots of other, these, the hydro mycelium products on the market for hangover. I want to know, get their work. Why they work, you know what, you know, what are, what are they doing to relieve hangover? And that's what brought us to today's conversation. As we started looking at the mechanisms of how the primary active ingredient, the hydro Mycetoma, how does it work and why does it alleviate hangover?

[00:13:59] And we had [00:14:00] some really exciting and initial data that was, wow, this is, this is acting on a lot of interesting targets. That would explain. Not only its potential as the anti-alcohol or liberal protective, but also how it might be working for Alzheimer's and some of these other areas that we've now associated DHM with.

[00:14:21] Um, as we started looking closer and closer. Proteins that affected the different organelles that it affected the mitochondrial, how it's acting on to increase mitochondrial bioenergetics. Some of your listeners I'm sure are quite familiar with mitochondrial bioenergetics yourself as a power lifter, you would have seen a lot of that activity with some of your power drinks originally, and so that really got us.

[00:14:45] And so now we've put our science hat on and we thought we want to share the good news and we, but we want to. Get to better understand the molecule to make it a more effective molecule and to try to promote its use, uh, were [00:15:00] necessary.

[00:15:00] Carl Lanore: [00:15:00] Well, and I want to, I want to expand on its use for a second, right? So we now understand from well done research, if there's a large portion of our population that have yeast and fungal infections in their gut, and when they eat sugar based foods and starchy based foods, they actually manufacture alcohol.

[00:15:19] Uh, a recent recent, um, article and, uh, an a newspaper talked about a woman who got pulled over breathalyzed arrested for alcohol. She has, she doesn't drink alcohol. She never drank alcohol and went to the doctor. And the doctor said, I can't believe it. Your body's producing alcohol. And she says, well, every morning I wake up with brain fog, I feel horrible.

[00:15:39] And when they, when they gave her antifungals and reduce the fungal load and the yeast load in her gut. Her blood alcohol levels and breathalyze alcohol levels went away. So, you know, there's a lot of people that don't drink but don't realize that their body is producing alcohols that could benefit from longterm exposure [00:16:00] to those alcohols, even in small doses by taking a supplement like this.

[00:16:03] The other one is more of a question to you. Sure. What about NAFL D we know that diabetics develop infiltration of fat in the liver. We know that this molecule, uh, may not only, uh, reduce, uh, the accumulation of fat in the liver from alcohol. What does it have an effect on people who aren't drinking alcohol but have their livers being infiltrated with fat?

[00:16:27] Dr. Daryl Davies, PhD: [00:16:27] The Josh, I'll let you take that

[00:16:28] Carl Lanore: [00:16:28] cause cause you're the liver guy.

[00:16:31] Dr. Daryl Davies, PhD: [00:16:31] It's touching on his dissertation project and we've gotten some really exciting data that that's promoting some of this understanding right now.

[00:16:39] Joshua Silva: [00:16:39] Exactly. So, uh, yeah. DHM uh, it's being looked at, investigated by other labs as well as we found some aspects from our studies that for nonalcoholic fatty liver disease, um, it does seem to benefit some of that glucose metabolism.

[00:16:50] Some of the limits. Regardless of if alcohol is present or not. And so, yeah, in some of those cases, some of those papers of studies, um, uh, initial, uh, studies in [00:17:00] humans just looking at DHM in terms of, uh, fatty liver markers or any kind of stress markers in individuals that might have nonalcoholic fatty liver disease.

[00:17:07] And so you had the DHM showing benefit there even from our studies. We're seeing some markers in the liver. That even though it's related to alcohol consumption, we're also seeing some benefit that might benefit the associated glucose tablets and have that strong benefit for

[00:17:21] Carl Lanore: [00:17:21] not. Okay. So Josh, they with me for a second with this.

[00:17:23] So there's recent research coming out on phosphodiesterase five inhibitors, Viagra, Cialis, and so on. They seem to also have the ability to reduce. Um, not only reduce fat deposition in the liver, but liberate fat from the liver, which are now saying, if you combine that with exercise, you get that sub straight back out into the bloodstream and you oxidize it through exercise, it can actually be used as an adjunct to a fat loss program.

[00:17:53] Do you think this molecule could do the same thing. So,

[00:17:57] Joshua Silva: [00:17:57] yeah, interestingly, what we're also seeing with this is [00:18:00] a lot of the markers that we're finding in the liver are in fact benefiting a fat breakdown in the liver, but also some of that transport to the mitochondria for energy usage. And so that's where a lot of our ideas are coming out for.

[00:18:11] Um, DHM benefiting the mitochondria in the liver. And then of course, other potential tissues like the heart or your lungs or any other kinds of muscles issue that might require a heavy mitochondrial use.

[00:18:21] Carl Lanore: [00:18:21] This is fascinating to me. So, you know, this is what happened, right? Um, I did a show recently about the benefits of taking nicotinamide, uh, to reduce fibrotic diseases.

[00:18:33] And when we came away from the interview, we realized that nicotinamide reduces. Fibrotic buildup in all tissue in the body. So w, you know, we always, these studies always have this domain, right? We're looking for these end points in this particular condition, but then we find out that they, that it has pleiotropic effects and multi tissue effects.

[00:18:51] So it stands to reason that it should be taken for more than just the original research. And this is one of those things, I have a funny [00:19:00] feeling. It's going to find its way into a lot of other things because of its potential. Um, you know, we call it stacking, but, uh, uh, what's the word I'm looking synergistic effects with some other supplements and not necessarily related to hangover.

[00:19:11] Very fascinating. Very fascinating. So, Dr. David, you want to, uh, um, remark about this?

[00:19:19] Dr. Daryl Davies, PhD: [00:19:19] So, yeah. So, Carl, Richard, what you've mentioned there is something that we're. You know, your audience probably already recognize as we're starting to recognize, we as a society, when we've tried to develop new drugs to treat diseases, we've always been one target, one disease.

[00:19:38] You know, we're only, we're going to treat diabetes by going after, you know, the, at the, at a particular target of the pancreas, for example. Or we're going to go for the Bluetooth Bluetooth transporter, but we're now starting, we're understanding. The biology. We're a huge, we're a machine, we're a massive machine, and that those drugs don't just affect a target.

[00:20:00] [00:19:59] We're a comp complex organism that's taken thousands and hundreds of thousands of years to evolve. And that evolution, um, I think part of what's happening, why this is happening is because, you know, nature's pretty smart. It says, you know what? We found something to work. Let's use that. Let's use that machinery.

[00:20:19] So most of the body. And when your body's healthy. All those loot, all those different applications were fine, but it's when you get a disease state and something goes out of whack that we, that we start seeing a breakdown, but we can't just treat a single target. We're learning that a drug doesn't have just a single effect.

[00:20:38] It will start getting multiple organs having different positive effects. Negative effects. That's where we have these answers, adverse events, et cetera, for drugs. Uh, you mentioned Viagra, right? Uh, when it was first being developed, it was being developed for

[00:20:53] Carl Lanore: [00:20:53] hypertension, blood pressure,

[00:20:55] Dr. Daryl Davies, PhD: [00:20:55] right? Blood pressure.

[00:20:56] And what happened?

[00:20:57] Carl Lanore: [00:20:57] Everybody got bonus. [00:21:00] It's just the truth, right? Josh? You

[00:21:04] Dr. Daryl Davies, PhD: [00:21:04] have 10 males, 10 young, healthy. Phase one. Phase one, clinical trials are normally young, healthy adults, males. We had the, you had these 10 males, um, being closely monitored, cause this was the first time this molecule was being tested in humans.

[00:21:19] And after about a half hour hour, so it'd be, you know, this story's been told so many times. The nurses noticed like six out of the 10 of these subjects when they were observing them in, in their, in their hospital gowns. Um, um, started rolling over on the Belize. And the nurse was, went in and asked, well, what's going on?

[00:21:38] And they all said, well, you know, I got this erection. I'm embarrassed. And luckily there was someone smart enough in that room and said, you know what? This isn't going to be very good for blood pressure, but this is, we just as we might maybe just hit a gold mine and then that then came Sunday, NFL or Viagra and then sales right behind it.

[00:21:59] So, right. [00:22:00] Well, recognizing that. We can study in vitro and I can draw beautiful pictures of targets and protein targets, and I can show you how the molecule interacts with that in a molecular model. But then you put it into the human body and this is why so many drugs fail. So, but on the other side, this is why instant benefit is, is what got me really digging into this as why is DHM doing so many good things?

[00:22:25] And then what are the shortcomings? What, what do we have to improve? Because we can talk later. But unfortunately, flavonoids, one of their problems, the reason why they haven't been really successful is that they have very poor pharmacokinetics, right? They're, they're

[00:22:39] Carl Lanore: [00:22:39] Porter short, very short, half lives in the body.

[00:22:44] Dr. Daryl Davies, PhD: [00:22:44] And so you have to improve the bioavailability. The reason we've been so successful with our studies so far right now is because to do preliminary data in mice, we're doing injections, IP, uh, injections. And so that bypasses the, the, um, the bioavailability. [00:23:00] We're not giving this orally. We're injected into the gut to interpret, fail

[00:23:04] Carl Lanore: [00:23:04] him.

[00:23:04] Dr. Daryl Davies, PhD: [00:23:04] Yeah. Yeah, and that's not going to be a, you're not going to do this for humans. People are not going to want to get an injection in the gut for the benefits of DHM, but it allows us to really understand the molecule and working with a colleague in rough Rutgers right now. On developing, um, looking at the strengths of the molecules and, and one of the things area's working on is developing novel molecules using the basic structure of the flab.

[00:23:29] Annoyed, but improving its pharmacokinetics.

[00:23:32] Carl Lanore: [00:23:32] You know, that that was actually done just recently with a honokiol. Which is a form of Magnolia that imparts an anxie lytic effect, but its half-life is like 15 minutes to an hour depending on how efficient your liver is. And a good friend of mine, uh, Justin Kirkland.

[00:23:49] Uh, who is a brilliant, uh, scientist turned, he modified it to be dihydro Hinoki oil and now it lasts four to six hours, and it's actually effective as an anxiety [00:24:00] lytic. And we have people on this show. In fact, you'll hear a commercial on today's show, uh, about a guy who had been using a benzodiazepine since he was eight years old.

[00:24:11] And he's off benzodiazepines because they've modified this, this flavonoid and made it stick around in the bloodstream longer and it's effective. Which leads me to my question and thank you, Ben Turner. Dixon said he ordered some last week. He can't wait to use it. Also, great to see the USC family hard at work.

[00:24:27] Fight on, obviously he's an ally. Uh, so, so you, you, you call this a drug doc. And I thought that was interesting because most people want to call it. Something other than a drug, but you refer to it as a drug in your paper. Why?

[00:24:43] Dr. Daryl Davies, PhD: [00:24:43] Right. So DHM is not a drug. It's a natural product. As you said, if it was a drug, we would have to go through an entirely different review process for safety and toxicity, et cetera, to the FDA.

[00:24:56] Um. So I go back and forth. As I said, my lab works on pharmaceutics [00:25:00] and natural products. And so I sometimes inter interlace, but at the end of the day, it has drugs like effects. It has drug like effects and, and we're using it to, to. Really investigate various targets to improve human health. You mentioned the beds that I asked you.

[00:25:18] One of its targets of DHM is the GABA receptor. And actually one of our projects that I'm, that dr gene Lang is, um, the fact that Josh is a coauthor on this paper, it's under review right now. Uh, we've been working for several years on his end, so lytic it, it looks like it's had these flavonoids have great angiolithic properties, but the non addictive.

[00:25:40] And, and, and you don't get tolerance like you would with a benzodiazepine.

[00:25:44] Carl Lanore: [00:25:44] I

[00:25:45] Dr. Daryl Davies, PhD: [00:25:45] mean, don't get me wrong. These are. Beautiful.

[00:25:49] Carl Lanore: [00:25:49] Yeah. But they, but they have, they have some horrible side effects. I mean, they, they, it, REM sleep disorder when used for sleep longterm, they actually have been linked to seizures when used longterm.

[00:26:00] [00:26:00] Uh, they are linked to memory loss, which can go away once you stop them. But stopping them is very, very difficult because the more you use them when, so, so when, when you use benzodiazepines longer and longer, when they wear off, the anxiety comes back. Stronger and stronger than it originally was. So  you know, I understand they have a great value.

[00:26:23] And there are some people that they've got to take them, but they're not. I'd much rather go with a natural product like, like this, if it has that same calming effect than a benzo.

[00:26:34] Dr. Daryl Davies, PhD: [00:26:34] Sure. Well, and last call, if you and I could get together, develop a benzo that Roche has never been able to, Roche has been looking at this for, this is what made Roche what it is in Switzerland, right.

[00:26:46] This is a one largest pharmaceutical company. If you could take all of the beneficial effects of that, of a benzodiazepine. Get rid of all the side effects. This would be a billion dollar drug, right? Because it has great, great potential, and it has [00:27:00] lots of, but it's the side effects, the tolerance, the addiction, the rebound.

[00:27:04] As you said, your body gets accustomed to drugs like this, and so the receptors of the proteins, they start to change and then you take the drug away and it's, it's a nightmare. Uh, diazepam, uh, was at one time, looked at as the, the, the new anti-alcohol drug. It was going to be the greatest anti-alcohol drug ever discovered because it's perfect to reduce alcohol intake.

[00:27:28] And Jill, about two or three weeks later when you become addicted to the benzodiazepine,

[00:27:33] Carl Lanore: [00:27:33] my father was given, my father was given value. To stop drinking, stop drinking alcohol. And then he took Valium for a very long period of time. And when he tried to get off of it, he developed anxiety. And then he had a wean off of those two was horrible.

[00:27:48] But he did it. And also, I'm sad to say this, but it's true, and my audience has heard me say it a thousand times, but when my mother was pregnant with me, she took, uh, she took Librium, which was [00:28:00] one of the early benzodiazepines. And I'm sure that I'm pretty messed up for some, you know, there's something going on in me that probably a result of her taking Librium and smoking cigarettes while she was pregnant, pregnant with me.

[00:28:11] Imagine what I would have been had she not done that. I scary thought we have to take a break. When we come back, we're going to talk about what actually happens during hangover. And what this product does to, uh, assuage the effects of hangovers. Stay tuned. We'll be right back with more soup. This is the superhuman channel where brawn and brains finally meet.

[00:28:40] Welcome back. We're talking about a magnificent little molecule that'll help you go out and party hard. But not feel like you got hit by a bus the next morning and play. By the way, we have lots of questions. I will get to all of them. I promise you we'll have time to get to all of them. So, uh, who wants to take this next [00:29:00] question?

[00:29:00] How does this molecule work?

[00:29:06] Dr. Daryl Davies, PhD: [00:29:06] Go ahead and Joshua, this is your dissertation.

[00:29:12] We've lost Josh,

[00:29:13] Carl Lanore: [00:29:13] have we, Josh? I know you are. Yeah. You don't, you guys don't have to, you guys don't have to mute anything cause I mute everything on my end. I should have said that.

[00:29:21] Joshua Silva: [00:29:21] Okay. Yeah, I'll go and take that question. Um, so as I mentioned earlier, there's some aspects that we're finding in terms of that fat metabolism.

[00:29:28] Um, more importantly, and I think you mentioned nicotine and might've been earlier. Uh, one of the key parts that we're really trying to, uh, expand upon with DHM is that the changes in energy levels in the liver, um, and this is also most likely true in other tissues. That's something that we're going to need to evaluate further on.

[00:29:43] Um, and we have found some aspects in the brain tissue. Um, but what DHM seems to be doing is, is increasing those energy pools of NAD. Um, and in doing so, those are key molecules necessary for alcohol, metabolism and clearance. And so essentially what it's doing is by increasing those pools, which is something [00:30:00] that we're working on, to better understand, it seems to be increasing the alcohol clearance, meanwhile, also providing a lot of that antioxidant benefits that might, uh, reduce that, uh, negative effects with the seed aldehyde, uh, which we maybe know is a very toxic with alcohol consumption.

[00:30:14] So as those concentrations increase, DHMC seems to be reducing those levels. By increasing antioxidant enzyme expression, they're going to be responsible for taking care of those, eliminating them, and eliminating a lot of the stress associated with that. But more importantly, some of those energetic effects.

[00:30:29] Um, that again, we're trying to see that relates to the mitochondria. Um, it's something that we're also looking into in terms of its angio lytic effects, but particularly in the liver, it seems to have a benefit increasing the alcohol metabolizing enzyme activity and therefore reduce those concentrations even faster.

[00:30:44] Carl Lanore: [00:30:44] But you realize, you just said it's an antiaging product too, because anything that increases NAD plus and reduces the, uh.  and I'm trying to think what the enzyme is called that breaks it down that they're saying that that will help us live longer and age [00:31:00] better. So you just said, and see it all come a long time ago.

[00:31:03] I said, isn't it funny that the name liver has the word live in it? And we know from the origins of names and words. That's not an accident. They must've figured out a long time ago that people who had healthy livers, it helped you live longer or live better. And so what you're saying here is that this increases that 80 plus and now, now, now you're saying it's an anti aging product.

[00:31:30] This is fascinating.

[00:31:32] Joshua Silva: [00:31:32] So that is definitely something we need to look further into. But yes, we are seeing the increase NAD plus levels. And of course with that, a lot of the benefits that if you look into studies on different flavonoids, including DHM, they often try to propose that it increases the aging levels specifically in like C elegans worm species.

[00:31:49] And this is because it's increasing those nav pools. And so yeah, there's, as you can see, there's a lot of benefit that we can really expand upon at this point. But in regards to that alcohol metabolism, this is what seems to also be influencing that [00:32:00] activity and clearance of alcohol from the liver as well.

[00:32:03] Carl Lanore: [00:32:03] So, uh, dr Davies, let me bring you in here to talk more specifically about the actual intrinsic, uh, heavy lifters here in this, and that is the alcohol dehydrogenase and a seal, a CDOT aldehyde dehydrogenase, these two enzymes specifically, I would imagine that part of the, the cytochrome people are 50 cascade.

[00:32:25] Correct. So,

[00:32:27] Dr. Daryl Davies, PhD: [00:32:27] so these are, uh, these are enzymes that are in, on the, in the liver, which is, as you know, as the main organ of metabolism for, for our bodies. She said, when I was a kid, my mom, once a week or twice a week, twice a month, we'd have to have liver and onions. You've probably

[00:32:43] Carl Lanore: [00:32:43] had that too. I still eat liver.

[00:32:46] A lot of it. Yeah.

[00:32:48] Dr. Daryl Davies, PhD: [00:32:48] Well, I mentioned it was such a good idea because now we know that what is delivers real job is. So to filter out all the toxins, right? So you can all just concentrate a toxin. But yeah, so the, so the, the men [00:33:00] main of metabolizing enzymes in the liver for alcohol, um, is this alcohol dehydrogenase.

[00:33:06] And if, if DIA high DHM only increased the. Uh, rate of metabolism of ADH, that would not necessarily be good because then we would just get greater amounts of acid aldehyde and acid aldehyde is related to what? Formaldehyde, these are highly toxic, highly, highly poisonous substances. And so, um. When we were looking at this originally, the cascade, we said, well, if it's, if it's clearing alcohol, what, what?

[00:33:36] What's happening to us now? The, and so we measured the levels of acid aldehyde and sure enough, it's a two step process that is, is, is, is increasing rate of, of alcohol metabolism, but also increasing the rate of acid aldehyde. Clearance. So we've, it converts it to acetate, which is water soluble, and then then the kidneys can clerk, uh, no harm, no foul.

[00:33:57] Um, so that's the really exciting [00:34:00] news about this is, is, is it's it, we now have this molecule. And we think about alcohol portion, people that are rushed to the hospital, for example, with alcohol poison, we don't have any really good tools to help increase the rate of alcohol metabolism. It's a, it takes about one glass of wine.

[00:34:19] Um. A can of beer or a shot of whiskey. It's about it. It's about one ounce of alcohol, 80 proof, um, alcohol to fully saturate. Um, this enzyme is ADH. And so every drink beyond that, um, you've, you, you've. Incapacitated, the body to metabolize. This is why it takes so long to clear the body of alcohol and why we can measure BCS whatever, ethanol concentrations or BAC, blood alcohol concentrations, for example, the breathalyzer.

[00:34:52] And then we can backtrack very easily how much alcohol you, you've, you've consumed. Um, but interestingly, uh, keep in mind that [00:35:00] women. Metabolize alcohol at a much lower rate than men. So the old water that, you know, men can drink a woman under the table. Um, and with the disorders, trying to take advantage of that and really promoting drinking in women.

[00:35:14] Now, um, um, this is really leading to some, some. Significant problems because now we're seeing the rates of of alcohol, liver disease, and the rates of alcohol, substance abuse, and other organ damage, um, increasing, much more significant in women than men. Men are kind of plateaued. They're already up to really high levels.

[00:35:35] Well, unfortunately, women are trying to catch up. And this is the worst area to catch up with is by drinking more alcohol.

[00:35:41] Carl Lanore: [00:35:41] So while it upregulates the biosynthesis of ADH and ALD H, it also increases the efficiency of how it clears. So this is really interesting because it, it, it makes the existing, uh, acetol, uh, aldehyde and, uh, alcohol [00:36:00] dehydrogenase.

[00:36:01] More efficient, even if it doesn't upregulate the production, but it does both of these, is that, is that correct? Josh?

[00:36:08] Joshua Silva: [00:36:08] That is correct. Yeah. So, uh, with long term administration of DHM, whereas we're continuously giving these mice DHM we're seeing it's increasing those instruction levels, but yet, at the same time, uh, with, with cell culture or even just quick, uh, assays with mice livers, we're finding that it's also increasing the activity of those enzymes, which, uh, short term responses or short term, uh, administration of DHS

[00:36:27] Carl Lanore: [00:36:27] as well.

[00:36:28] So, so talk about the study for a second. You gave these rodents, 34% of their daily caloric intake was ethanol, right? Correct?

[00:36:38] Joshua Silva: [00:36:38] Uh, yeah, so they were consuming about 30%, uh, alcohol volume by volume, uh, for about an extension of eight weeks, which is allowing them to consume. It was almost about 40 to 50 grams per kilogram of ethanol per body weight.

[00:36:52] So this is extremely high levels. These are going to cause him to be intoxicated, but not only that, with the continued consumption of this every day, this is for [00:37:00] sure going to induce and as you saw, it's going to induce a lot of that damage to deliver and most likely other tissues.

[00:37:05] Carl Lanore: [00:37:05] Now where these just male rodents or were they commingled with female rodents?

[00:37:09] Just curious. These

[00:37:10] Joshua Silva: [00:37:10] were male note. I wrote ins right now for our initial studies,

[00:37:13] Carl Lanore: [00:37:13] it would be interesting to see the effects of that much alcohol on lower doses. And and meeting because I wonder if they would be more prone or less prone to copulate given that they were pretty drunk. Yeah.

[00:37:27] Joshua Silva: [00:37:27] Yeah. So there's some differences there, and there's a lot of other studies that we could expand on.

[00:37:30] And you touched on some good points in terms of looking at other effects that this might not only benefit, but also looking at that alcohol, extremely bad, high of alcohol consumption on those effects and behaviors as well.

[00:37:41] Carl Lanore: [00:37:41] I, you know, I don't speak rodent, but I can guarantee you that this phrase was being used often in the cages.

[00:37:47] I love you, man. I love you too, because that's what guys do when they get drunk. They stopped professing their love for anybody that's close to them. At least the guys I hang out with anyway. Um, so it reduced fat [00:38:00] accumulation, lipid accumulation. So we've addressed that already because that was part of the, uh, potential, uh, in treating fatty liver disease.

[00:38:05] But it also seemed to reduce some very, very bad inflammatory markers like cytokines, right? Doc, you want to take that.

[00:38:14] Dr. Daryl Davies, PhD: [00:38:14] As well, so I'm, I'll let Josh chime in. Also, guys, I said this is dissertation, but when we started looking into this, once we, once we found the initial data and then we're starting to see liver restorative effects, then the next question for a scientist is, okay, let's start looking at the molecular look at the signaling pathways, and we know, and this is what part of what we think is, is causing the hangover.

[00:38:39] Is when your body has a reaction, a immune response, a part of that immune response to Iowan ILA and others. Um, it was, it was a, this inflammation we've been hearing all about inflammation with Colvin, right? Because that's what, that's an immune response. The body trying to fight this off. And so you have these cytokines, and when you have these, when [00:39:00] you have these cytokines circulating, they're there to try to protect the body that sends those foreign invaders or whatnot.

[00:39:06] But when they get out of control. They start having bad consequences. And so part of that bad quad consequences with a hangover, headache, nauseous, you know, you're tired the next day, you know you're foggy. And so we asked the question, can we look at some of the common markers, some of the cytokine markers that are easy to measure and did DHM we do so.

[00:39:32] You were predicted that that should based on the reduction of acid aldehyde and sure enough, that's what we found.

[00:39:40] Carl Lanore: [00:39:40] So, um, another really good question. Alyssa just texted me with this one and she said, is this dose dependent? So in other words, if I, and Josh, you're a young guy, I gotta believe you go out with your friends, at least when there's no pandemic going on.

[00:39:53] Have you experimented with this compound? And do you have to take more if you're going to drink more or what's the deal.

[00:40:01] [00:40:00] Joshua Silva: [00:40:01] So,

[00:40:01] Dr. Daryl Davies, PhD: [00:40:01] uh, for

[00:40:02] Joshua Silva: [00:40:02] products such as the morning recovery product is one that has DHM. And that's something that I think many are familiar with. Uh, they're very good with their marketing, so it's, it's out there.

[00:40:11] It's public. Um, so I've taken this before and, uh, the dose of it, or essentially the way it comes, is this a little mini bottle? I think about, uh, the a hundred milliliters

[00:40:19] Dr. Daryl Davies, PhD: [00:40:19] or something I could show that I can show,

[00:40:21] Carl Lanore: [00:40:21] hold it back, turn it around for the front of it. Yeah. There it goes. Okay. Okay. It's like a shot.

[00:40:25] It's like a shooter, like, like an energy shot, like an energy shot. Correct.

[00:40:29] Joshua Silva: [00:40:29] So depending on like your body weight, you might want to take half of it if you're going to consume it. If you're a little bit more on the lighter end, um, if you're a bigger guy, you're going to want to consume the whole thing while you're doing your drinking session, or I believe at least an hour after the effect or after the fact.

[00:40:44] And in doing so, that's going to help prevent a lot of the hangover symptoms. And interestingly, what other people will also report is that they don't feel as

[00:40:51] Carl Lanore: [00:40:51] intoxicated. Exactly. So, so the, I got a brilliant idea guys. We have to do this. Okay? [00:41:00] So we have to get bars to start selling. You remember, remember the a, when they started mixing red bull with vodka, okay, we need to mix this with a, with an alcohol.

[00:41:09] So you just never get drunk. You ended up burning up a thousand dollars a night at the bar. You just keep throwing them down and you're like, I'm not drunk yet. Give me another one. I'm not drunk yet.

[00:41:20] Dr. Daryl Davies, PhD: [00:41:20] One of the jokes,

[00:41:23] Carl Lanore: [00:41:23] and

[00:41:23] Dr. Daryl Davies, PhD: [00:41:23] one of the jokes that we have is, you know, you're taking DHM and you're drinking a a 25 year old McClellan's or something.

[00:41:30] You're wasting your

[00:41:30] Carl Lanore: [00:41:30] money. Yeah, right. Exactly.

[00:41:32] Dr. Daryl Davies, PhD: [00:41:32] We have this burden through the alcohol, but I do want to bring to your audience is, and this is the criticism that we've gotten in the past when we were trying to develop these hangover remedies, for example, we're not trying to promote. Bad drinking. What we're, we're scientists that we realize that people have.

[00:41:51] There are 17, 18 million people in this country alone that are abusing alcohol or beer that's not going away. So let's see if we can find ways to [00:42:00] reduce that risky drinking or reduce the consequences of the risk breaking until they can change their drinking patterns. Um, and when we talk about hangover, um.

[00:42:12] You know people, and we've talked about this and I think our article a little bit, but you think about these side effects, the next day you're foggy. You're kind of slow. Now think about yourself being in a crane operator. That's 16 stories up, operating a heavy crane, and you. And you're

[00:42:31] Carl Lanore: [00:42:31] saying you're hung over from the night before.

[00:42:32] Listen, we had, we had the commercial pilots who were using the oxygen before they would get in the cockpit to fly, to try to sober up from the night before. This would be a great thing for them. They could use this and, and you'd be safer on that plane. So, so real quick before we take our last break and then we're going to start answering questions.

[00:42:49] So if I was going to go out drinking. Should I pre-treat with half a bottle and then after I've gone out drinking, drink the other half of bottle so that I, I've prepared my [00:43:00] liver. I won't get as drunk cause I may have to drive later. On top of that, I'm going and I know neither one of you will propose supporting the idea of drinking and driving.

[00:43:09] That's not my point. But is it worth pre-treating and post treating as opposed to just waiting till I'm done at the end of the night and then taking it.

[00:43:16] Dr. Daryl Davies, PhD: [00:43:16] So what I would suggest is, is these little three ounce or two ounce, three ounce bottles, they're not that expensive. Um, we've done, we've done toxicology on these where we've poured this stuff down.

[00:43:29] The rats, I mean, unbelievable concentrate. This stuff burns out so quick. I would take a bottle before you drinking and I would take an extra bottle after the fact. Uh, the more labs, when they were first starting to market this, I don't know if they're still doing it, but they had it in like the Uber's and whatnot.

[00:43:45] They did have their bars. They, they were trying to get it out, marked it in different places. What I would tell the, as I told you when we were talking privately ahead of time, I wasn't using it for alcohol, but I was using it because of my inflammation. When I was having that deep, deep bronchitis. [00:44:00] I just chug a bottle.

[00:44:01] It tastes good. It's sugar-free, no calories. You know, it's, it's like take advantage of it because it's been formulated to somewhat. Be absorbed into the bloodstream are much better than some of the other products are out there. Right,

[00:44:14] Carl Lanore: [00:44:14] and you guys are not receiving any, you already told me this. You guys received no remuneration for the promotion of this.

[00:44:20] This is, you're all about the science. There's no, there's no, you're not promoting this product to any other particular product because you got any kind of vested interest.

[00:44:28] Dr. Daryl Davies, PhD: [00:44:28] No, we, we, we, I don't have stocks. In fact, when I first started partnering with this company, we had an eye on the stock option that I declined because I'd wanted, uh, they did donate some money to the lab,

[00:44:39] Carl Lanore: [00:44:39] pure science,

[00:44:40] Dr. Daryl Davies, PhD: [00:44:40] unrestricted funds.

[00:44:42] In fact, I think we had a bit of a falling out because I said, look it, I'm doing the science. A donation means that we do the science. Um, but it's a great product. It works. And we're trying to promote it to get it out there. Uh, because it, it does what they claim it [00:45:00] reduces handle, but also has those liver protective effects.

[00:45:02] And yes, we get no, we get no money for this. No stock, no, no kudos. Nothing from the company.

[00:45:08] Carl Lanore: [00:45:08] So I want to take our last commercial break for this segment and bring on some of the questions we have lining up here. Then later in the show, people love, bye. Uh, my critical thinking as it relates to this pandemic and my rants, I'm getting more and more emails.

[00:45:24] So at the end of the show, after my guests. Uh, gone because trust me, they don't want to be on the air with me when I do this stuff. They want to say they don't even know this guy. We don't even know. We never met. I've never met him before the show, but I have a good rant for you today as it relates to the pandemic.

[00:45:37] So we're going to take one quick commercial break. Stay tuned. We'll be right back. You are listening to the superhuman channel. We're ripped and we're ready.

[00:45:50] We're going to have Joe and Ben from Piedmontese beef on. I believe it's the 20th of this month. You need to tune in because there is no other beef in the world. First of [00:46:00] all, real quick, the Piedmontese breed from Italy is a mile Staton no cow and bowls, which means that they have unrestricted muscle muscle growth.

[00:46:12] But here's the interesting phenomenon about myostatin no, because we've been talking about myostatin on the show since I had Sasha and Lee talk about it when he discovered it and thought he was going to solve a lot of neurodegenerative diseases. The muscle produced in myostatin. No animals have impaired collagen production and collagen is what makes muscle meat tough.

[00:46:35] These are the most tender cuts of beef, even if it comes from the shoulder, I mean, their shoulders are typically, Oh, that's, that's, you know, cube steak. No, it's like filet, every piece of meat from these cows is like filet and it's rich and it's delicious. And. They are raising them here in the United States.

[00:46:52] I got an email from somebody saying, Hey Carl, what are you doing? They're running out of beef. I'm not running out of beef. Ben and Joe from piedmontese.com [00:47:00] deliver it right to my door, and if you use the code SHR, you'll get two free 10 ounce New York strips with an order for as little as $50 it's insane.

[00:47:11] You got to check them out. Okay, now let's work some questions in. So we're going to re work right from the top down and the order that they came. So John peaks is a good friend of mine. He's an over the road truck driver. He's asking me if you think the quality of alcohol plays any role in its ability to create a hangover.

[00:47:29] Who? Who wants to jump on that

[00:47:31] Dr. Daryl Davies, PhD: [00:47:31] one? Josh. Oh yeah. Uh,

[00:47:33] Joshua Silva: [00:47:33] so yeah, depending on that quality of alcohol, um, the way the fermentation process exists, uh, even if you look at, you know, Brown liquors versus clear liquors, uh, there's this difference in this production of conjures that are going to be produced in that process.

[00:47:46] And these are one of the multiple ways that might contribute to a hangover. But yeah, depending on that quality of alcohol that's being consumed, of course the amounts of it that's going to increase that likelihood of the hangover. And so, uh, this is mostly seen with darker liquors. [00:48:00] Uh, so scotch whiskey, uh, especially at quarter quality scotch and whiskey, you're going to have higher accumulation of those conjures with the, uh, the fermentation process or that, uh, alcohol production process.

[00:48:10] And so when that, there's also increased likelihood of hangover. So definitely the type of alcohol that's being consumed and have a, you know, a higher influence on whether you get a

[00:48:18] Carl Lanore: [00:48:18] hangover or not. So we know sugar impairs liver function. We know that from type two diabetics. You think sugary alcohol drinks or a double whammy.

[00:48:27] Joshua Silva: [00:48:27] Yeah. Uh, so yeah, one of the common complaints is, you know, higher sugary beverages with alcohol are going to increase the likelihood of the hangover, and that's due to the fact that I'm in factors associated with that glucose metabolism, uh, on top of the absorption process of alcohol. That's going to also increase those kinds of concentrations and increase that likelihood as well.

[00:48:46] Dr. Daryl Davies, PhD: [00:48:46] Okay. And also keep in mind that you know, a lot of these things that we're talking about are, are in a generic person, right? So we have individuality between us and Josh might metabolize alcohol differently than I [00:49:00] do differently than Carl does. And so some of this, but we can tell you in general why sugary drinks or why the cheaper alcohols, when I said the air force.

[00:49:10] 30 some years ago, George tickle, uh, down in Texas was a common one, a bourbon that we used to drink all the time. But, um, it really is, it's part of it is the individual identity of, of the person and the way that, the way that the drink is presented to them.

[00:49:29] Carl Lanore: [00:49:29] But DHM should help. In all those cases. Bottom

[00:49:32] Dr. Daryl Davies, PhD: [00:49:32] line, you know, we, we, in fact, one of the areas that we really want to look at is like what you call the Asian flush, uh, people that are deficient in one, um, to see if it actually might even help, uh, might improve those individuals that have really suffered.

[00:49:47] So

[00:49:47] Carl Lanore: [00:49:47] wait a minute, really? Eight, it's called the Asian flush, right? If they actually get flushed from drinking alcohol,

[00:49:55] Dr. Daryl Davies, PhD: [00:49:55] right? So the, so the agent flush, uh, Carl, uh, is, it's. [00:50:00] It was started originally. Um, a diff, a deficiency in ALD H one, um, is, which is ALD. It's one or two. Josh. I always get these two mixed up now.

[00:50:14] And then, yeah. So yeah, cause one is mitochondria and one of the ones, the other one, so this is 500,000 years ago, started up in upper China and that has worked its way through the world. So it's not just Asians now, but depending on the severity of the, the ALD H to the deficiency, some Asians just get mine, Marley flushed.

[00:50:35] Um, some get deadly set. And th, and this is the same principle with , which was the first anti-alcohol drug developed in the fifties was that it blocked the conversion of acid aldehyde to acetate. And so when you block that ALD H two and the person gets a build up of acid aldehyde, they get deadly sick, they start to vomit, barf, et cetera.

[00:50:56] And the idea was they quit drinking alcohol,

[00:50:58] Carl Lanore: [00:50:58] but I have a [00:51:00] good friend and we thought it was just white wine, red wine. And maybe it is, but she gets very flush after having wine and she's never had this problem before. It again is are these enzymes part of the people 50 cytochrome cascade? Josh.

[00:51:17] Joshua Silva: [00:51:17] So they're a separate set of enzymes.

[00:51:20] But, uh, on that note, there is one, the sip, uh, Tuohy one is going to be one that's involved, but that's more so in cases where the individual is constantly consuming alcohol and what's going to end up happening.

[00:51:32] Carl Lanore: [00:51:32] Exactly. But could you, as you age, lose the ability to create the end, the, uh, the a L D H two, and now all of a sudden develop Asian flush.

[00:51:44] Joshua Silva: [00:51:44] So on that note, if, uh, one of the common factors of aging is this depletion of NAD pools. Uh, and this is, you know, highly contributed to a lot of the neurodegenerative diseases that are being studied at this point. So in that case, if that is applicable in the liver, I guide up to see if that is also being [00:52:00] confirmed as well.

[00:52:00] But if NAD levels are also being depleted in the liver, not only just from alcohol consumption but aging, then it's possible that the efficacy of the enzymes might change as well. So that is potentially something, but it might need to be further evaluated before confirms.

[00:52:13] Carl Lanore: [00:52:13] So Josh Hartnett says, back when I did drink parenthetically a lot, I tried DHM and I do know it works.

[00:52:21] Um, I chose not to drink anymore. I put a 40 year limit on myself. Ha ha. That is funny. But anything that helps with the breakdown and filtering and liver function, especially a natural product. Well, that's just good news. And I agree with him about this because we know that, uh, liver function is very, very closely tied to, uh, better aging.

[00:52:46] So I would agree with them there. The next one is a question I think. Let's see here. He said, uh, Carl, uh, could you stack this with activated charcoal and or Thorne? I don't know what thorn is. I always take [00:53:00] activated charcoal and ed Foran. I always thought thorn was a brand, not a product, but maybe I'm wrong.

[00:53:05] I always take activated charcoal and add thorn to it. If you guys could talk about that. Do you know what he's talking about? Foreign.

[00:53:14] Dr. Daryl Davies, PhD: [00:53:14] No. But we used activated charcoal, and for example, when the patient comes into the emergency room, we will use activated charcoal to try to help filter out the alcohol. Um, so, so you can use it in, in that regard.

[00:53:29] But the thought is probably some natural products.

[00:53:31] Carl Lanore: [00:53:31] Yeah, I think so too.

[00:53:32] Dr. Daryl Davies, PhD: [00:53:32] I apologize. I guess this is, David asked the question. I just don't know the answer on that.

[00:53:37] Joshua Silva: [00:53:37] Well, just looking at it real quick, it looks like the Warren is a product used for electrolyte balance, so I mean it in cases where hangovers, you know, involved.

[00:53:46] Uh, one of the reasons is the electrolyte imbalance. So it restore some of those little Australia balances. If you're using a sports drink beverage, try to recover some of those electrolytes that has been reported to have a lot of effects, but it's not very well confirmed at this point. [00:54:00] But a lot of people have been finding benefits with that as well.

[00:54:02] Carl Lanore: [00:54:02] So Scott Lala, who listens to the show quite often and has been a big supporter of the show, he and I share something in common. We're fascinated with peptides. I've been doing shows about peptide since 2006 not just growth hormone, but all of these novel peptides that are coming out. And one he's asking a question about specifically is one that I use daily as a prophylactic value.

[00:54:25] And he said he wonders if you know any theories of regarding BPC one 57 do either of you know what that is? No,

[00:54:34] Joshua Silva: [00:54:34] I did a quick search and I see that it's a peptide used for a lot of anti-inflammation. It looks like it seems to benefit acute intoxication. Uh, so there's several properties associated with, but I'm not heavily, you know, uh, comfortable with that understanding.

[00:54:50] Dr. Daryl Davies, PhD: [00:54:50] Others have looked at peptides and there are, there are, there's some Gail woods and some of these others that are be looked at. A lot of the challenges with the peptides is getting an image. The brains. You know, get to get [00:55:00] them into the brain if you're going after the target in the brain itself. Yeah.

[00:55:05] Carl Lanore: [00:55:05] Inhalation. No, no. I, so I'm going to tell you a fascinating thing. So I'm, I'm dark. I'm Southern Italian. I'm actually 14% Northern African, and so I'm dark to begin with, but I've been experimenting with, so I'm sure you've all heard of mulatto 10 to university of Arizona, created it to help fair-skinned people.

[00:55:24] Uh, uh. Pretreat their skin before going on vacation. It's basically a melanocortin stimulating hormone, but a thousand times stronger. You take very, very small doses daily, like 25 to 50 micrograms. You develop a tan before you actually go to the beach. The problem with it is nausea. The more melanin you have in your skin, you develop nausea, uh, you, you, you.

[00:55:45] Get flush, uh, you can't sleep because mulatto Courtin, uh, the melanocortin does a hormone cascades. They have amazing benefits, but also they're very, very neuroactive. You know, when you lay out in the [00:56:00] sun, it gives you energy and so on and so forth. So what I did was I took a Mulana court, took mulatto 10, two.

[00:56:08] And I mixed it with a sodium chloride solution with a tiny, tiny, tiny little bit of benzyl alcohol, and I put it in a metered nasal. Spray bottle and I take a 50 micrograms intranasally every morning. It wakes me up. First of all, it has profound, uh, uh, anti inflammatory effects on the brain, and it's making me tan again.

[00:56:30] I'm getting 10 without the purple lips. When I used to inject it, my lips would even turn purple. So I would think that BPC one 57 intra-nasal uh, Scott, if you go back to some of my videos on YouTube on how to make your own. Uh, do DIY intra-nasal peptides. You may want to make some BPC one 57 and take it for a ride one night after going out drinking and see what happens.

[00:56:50] There you go. It goes right to the brain, right to the brain. There you go. Hey doc, I should come to your class and I could learn pharmacology,

[00:57:00] [00:57:00] Dr. Daryl Davies, PhD: [00:57:00] pharmacology courses.

[00:57:02] Carl Lanore: [00:57:02] Yeah. He said, okay. Uh, it's millennium millennium. Gleiss glycinate is what thorn is. Yeah.

[00:57:14] Dr. Daryl Davies, PhD: [00:57:14] There's a lot of these products that are out there and, and what we're trying to do is bring the science we're trying to understand, in our case, DHL, but we're also looking at other products, other, other, uh, other natural products.

[00:57:28] There's just bring the science, the science that w the way we're trained to try to have a better understanding. To find out what are the, what are the key signaling proteins, the key signaling enzymes, et cetera, things that we can manipulate to have the best outcome for the general public. Um, but there are a lot of products out there, and what we're trying to do is filter through the noise and give, rather than poo-pooing natural products.

[00:57:54] To identify why they work, explain why they work, and so then the, then the individual could make the [00:58:00] decision to buy it product or not, but at least we have some science behind this.

[00:58:05] Carl Lanore: [00:58:05] This is fascinating stuff. I love it. I'm going to, I'm one, I'm going to get some of the stuff that you showed in the bottle.

[00:58:09] I'm going to give it a run because I can no longer drink alcohol unless I am. I'm willing to accept the fact that for the two days after, I'm going to feel horrible. And so I'm going to give this stuff a run. I know that Elisa hates drinking alone now because we'll go out to dinner and I'll pour a glass of wine and I won't drink it, but I don't want to be antisocial.

[00:58:29] But the reality is I've always loved, I've always loved drinking. I feel like it lubricates the soul and makes you more interesting, or at least you think you're more interesting. I don't know which one it is, but I'm going to give this stuff a try. I really appreciate you guys coming on the show and talking about this compound.

[00:58:44] Dr. Daryl Davies, PhD: [00:58:44] Well, thanks so much. Cool.

[00:58:45] Carl Lanore: [00:58:45] Hope you enjoyed it. And, uh, and please, I know you're working on something else. I don't want to let the cat out of the bag, but when you guys start working on the, uh, anti caffeine stuff, I'd like to know more about that.

[00:58:57] Dr. Daryl Davies, PhD: [00:58:57] Sure. Okay. And be sure to tell your audience, [00:59:00] I'm always receptive to emails.

[00:59:03] It's D This email address is being protected from spambots. You need JavaScript enabled to view it.. Uh, I'm happy to answer questions. Um, I. I will give you a straight answer that I know. Um, so if any of your audience would like to follow up or want more information about what these products are, why do we think it works? I, we'll continue this line of investigation. Um, so I'm happy to, to address those

[00:59:24] Carl Lanore: [00:59:24] questions.

[00:59:25] Thanks so much and thanks for being here today and stay, stay covered. Free guys. Okay.

[00:59:30] Dr. Daryl Davies, PhD: [00:59:30] Over three and I'm going to get some of that, I guess as

[00:59:33] Carl Lanore: [00:59:33] legends. Is it? Oh, legend. Eat legendary.com legendary foods and also tried the Piedmontese beef. I promise you, you'll never eat any other kind of beef.

[00:59:41] Dr. Daryl Davies, PhD: [00:59:41] I listen to your show and I'm already getting sold.

[00:59:43] Thanks.

[00:59:44] Carl Lanore: [00:59:44] Oh, you know what, I, you know what else? We have a device that is basically a $10,000. Brain assessment device that looks like a mouse that sits on you and you can actually measure plasticity, your learning capacity, everything right on your table. You'll never [01:00:00] hear the products that are on my show because I have the most intelligent audience in the world.

[01:00:04] They're all interested in being stronger and living longer. All right guys. We'll talk again soon. I promise. We're going to take one quick commercial break and when we come back, I'm going to give you a rant on some of the things I want answers for as it relates to covert 19 stay tuned. You've heard about blood.

[01:00:19] Oh, that's not right. Hold on a second. Here we go. Here we go. This is the superhuman channel.

[01:00:33] Welcome back. So I'm just like you and I really mean that when I say that, I know that I have a lot of the same thoughts you're having about this pandemic. Case in point is. Since I've been wrapping up pretty much every show the past couple of weeks with a little rant or a little opinion or a question, you know, I'm getting emails from people and they're going, dude, I mean, even some of them are [01:01:00] posting live while I'm making the comments.

[01:01:01] They go, I know exactly what you're going to say, and it's because we're all critical thinkers. We don't just take what someone tells us and go, Oh, okay, well that's it. And we definitely don't agree when somebody tells us to shut up and obey because that is antithetical to what we are all about in this audience.

[01:01:22] Hell, you don't even take everything I say. People challenge me on the things I say, and I love that. I love that I'm not one of these people who thinks I'm a guru. And if you tell me I'm wrong about something, I want to fight you over it. I'll look at your opinion. Maybe I'm wrong. I've been wrong a lot.

[01:01:36] Trust me. Just look at the path of my life. I've made a lot of stupid decisions. So here's what I want to know. We hear that, uh. And we've all heard this so many times. The CDC owns the patents on X number of vaccines. I've lost track 28 30 32 I hear different numbers all the time. [01:02:00] I want to see the budgetary line item in the federal budget that shows what money, if any, maybe it's nothing.

[01:02:08] Maybe they own these patents and they don't. They just want to own control of it for security purposes, like, Oh, we can't let other people on these patents. They'll take advantage of the American people. It could be that it really could, right? Or it could be that the government actually makes money, right?

[01:02:22] They take these patents, they licensed them out. They pay these pharmaceutical companies to create. These vaccines, they own the patent. W w we own the patent, right? The American people, we own the patent, right? CDC runs on tax dollars. So every one of you takes a penny, maybe out of every dollar you pay in taxes and pays their, their payrolls, right?

[01:02:45] So, theoretically or truthfully, we own the patents, the American people. Um, and as such. We should know how much are we making on those patents we own. We don't want the money. Not like we're saying, [01:03:00] Oh, you owe us money, but shouldn't we at least know? Don't the board of directors, aren't we like the board of directors?

[01:03:06] The government works for us. We pay their salaries. Shouldn't we know if those patents are making money or not? Is the government getting money licensing? Because don't forget. We indemnify the pharmaceutical companies that make vaccines. They don't get sued when there's a problem, regardless of, I'm not an anti-vaxxer.

[01:03:29] I actually think vaccines have a place. Uh, we know that hormesis is real. We know that being exposed to something builds up, uh, your ability to resist it. We know this, you know, I'm not an anti-vaxxer, but all I want to know is what does it mean. For the CDC and that their goal, therefore we American people.

[01:03:54] What does it mean that we own the patents on these, these vaccines? [01:04:00] Why do we own them? Is it just because we want to control them so that other people can't and then take advantage of the American population? It could be that. Or do we, do we own them through the CDC because the government makes money on the companies that sell the vaccine.

[01:04:16] Oh yeah. We own the patent. So every time you give a vaccine, we get 10 cents. And what does that number mean to the government? We should know that. And here's why. Just like at the beginning of the show, in the middle of the show that I just did with these two gentlemen early on. I asked him, are you guys working for this company?

[01:04:33] No, we don't. In fact, there's lots of companies that use this compound, a D H M and an anti hangover product. It's not patented. Anybody can make a supplement with it and they just happened to use this one because for themselves. I want to know that I want it. If you guys are making money on this, then we're not going to talk.

[01:04:56] We're not going to mention the product. I'm not plugging somebody's product so [01:05:00] you can make money. I want to talk about the science and that same fashion. The government is in the position to both select advise and in some cases even mandate like they're trying to do, they're trying to force people to get vaccines.

[01:05:17] Now. Do they have a vested interest to do that? Are they looking at it like foul cheat meal? I don't think Fowchee is making money in his pocket, but is he, if he was the, if he's one of the company and his compensation plan is based on the profitability of the company, then indirectly he is making money for the success of the company.

[01:05:44] And if the owner, the CDC owning, uh, whatever number of vaccine patents that they own while he was in charge, then. And is he with the CDC or the [01:06:00] national institutes of health? I forget, but my point still stands. I may have, I know that people are gonna say, Oh, call, you know what you're talking about, because he's not the head of the CDC.

[01:06:08] And it may be, I really don't pay a lot attention to politics, to be honest with you. But my point is, if the American government through the CDC, which means the American people own these patents, shouldn't we know how much money they make for us? And if they are making money for the government. Then shouldn't they be excluded from being in a position to require them or suggest them?

[01:06:33] Because isn't that then a vested interest for profit? This is a legitimate question and you should be asking yourself this too. I don't care what side of the fence you're on. Don't you want to know if the government is doing the right thing by investing in these patents? By owning these patents, are they protecting us from losing control of them?

[01:06:55] Uh, you know, are they international patents with other countries? Can't make them and just rip them [01:07:00] off. And if so, do they have to pay a licensing fee to use these patents? And if they pay a licensing fee, how much money do does this the CDC and other government agencies make from that? And who's overseeing that?

[01:07:15] And is anybody seeing this from a standpoint of. Forcing people or recommending people get vaccines so they can make money. Cause think about it, you know, all day long we hear about the seasonal flu, get your vaccine and get your vaccine. Well, the value of that advice may be good, but it somehow becomes tainted.

[01:07:37] If the person telling you to get the vaccine is actually making money from you and getting the vaccine.

[01:07:45] No, I'm just asking this question should a logical question, just a logical question. Who is benefiting? Who is profiting? How much are they profiting and, and w and why do they own these patents in the first place? You know, is it because of a [01:08:00] control is because of profit and we, we need to find this out. I wish I had an investigative reporting team.

[01:08:06] That I can send after this and find it, because I looked for these numbers for a while the other day, and I got bleary-eyed looking at federal budgets. Uh, I couldn't find anything. I could find individual line items for the NIH and the CDC and the FDA. I could find those budgets. But somewhere hidden in those numbers is the vaccine patent related information.

[01:08:31] So if anybody's listening to the show. And you can find that information for me. I'll put you on the air and we'll do an investigative reporting piece. And it doesn't have to, and I'm not saying, Oh, we're going to go anti-government. It may be that the government, cause I suspect this, I think the reason they want to patent these really important things is because they wouldn't want to China to hold a patent and then have control over the vaccine, potentially saving lives here in the audit state.

[01:08:58] That makes perfect sense to me. [01:09:00] But is that really yet. Is that really it? So anybody out there who wants to take this upon themselves, email This email address is being protected from spambots. You need JavaScript enabled to view it.. If you start digging around, you find information, uh, you'll come on the show with me and I'll ask you those questions, those same questions, and then you answer me.

[01:09:18] No, Carl, they don't make any money, uh, but they do patent them because they want to control them so that they don't fall into wrong hands. That's the altruistic government that I want to believe in. That's what I want to hear. So prove me wrong. All right. That's it for today. We have great shows the rest of the week, or it's already Tuesday.

[01:09:36] Uh, I can't remember. Oh, this Friday we have a pep talk. Dr Elizabeth YDS has got to come on. We're going to talk about  and other  peptides. Uh, their ability to, um, regrow hair and other, other benefits that they have. So that's going to be good. Yeah. Look, Christine, who I know. [01:10:00] So they'd love to have an independent investigation team.

[01:10:03] I would, if you think you can do it, anybody, I don't care who you are, email me and I'll give you the tasks and you do the reporting and literally become a journalist right now on this show. I would love it. Please help me cause I want to get these answers for the audience. I just don't have the time to do it myself.

[01:10:21] I'm dancing as fast as I can. Christine, maybe it's you. Maybe you're the person that can do this for me. I would love nothing more. I look, we'll see everyone tomorrow with more superhuman radio. Please share the show. Especially this one, save people the aggravation and the ill effects of a hangover. And like I said, it doesn't have to be the product they talked about.

[01:10:43] There's lots of DHM products out there. I have found that lots and lots of them, Elisa is looking through them, uh, for me. In fact, I see tomorrow share the show. Thanks a lot. [01:11:00]