[00:00:00] [00:00:00] Carl Lanore: [00:00:00] Hey, Hey, welcome back to another episode of super Yuma radio. Today is an episode of the pep talk. Some of you have been missing these. We're going to start doing more of them again. Uh, it's May 8th, 2020. We are 51 days into the covert 19 compression, uh, home. I want to say home incarceration program. I'm in my room all by myself, so I don't have to worry about it.

[00:00:25] I'm always social distancing, and in fact, I am such a boring person that I just realized I've been social distance thing my whole life, so I'm all prepared for this. We have a great show today we're going to be talking about a unique peptide called H K CU that she used stands for copper. All of its benefits, uh, with dr Elizabeth yurts.

[00:00:46] We're gonna start in that, uh, on that topic in just a minute, but I just have to remind you that our title sponsor is legendary foods and they have a super deal, uh, for my off audience. Uh, you can save [00:01:00] 10% off This email address is being protected from spambots. You need JavaScript enabled to view it. by using the code SHR 10. They're tasty pastry is ridiculously amazing.

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[00:01:58] The people and the stuff they [00:02:00] have at eat, legendary.com 10% off. Check it out and tell them that Carl sent you. So now we're going to bring my guest on who is a returning guest and many of you appreciate and love her. And that is dr Elizabeth year. Oh, wait a minute. What happened? I did something wrong.

[00:02:18] Just give me one second. Here we go. Hide that I that. There we go. Eh, she is. Oh, one more thing to hide. I'm my own producer here. At the, uh, the studio. How are you doing DACA?

[00:02:31] Dr. Elizabeth Yurth, MD: [00:02:31] I'm good. Thanks.

[00:02:32] Carl Lanore: [00:02:32] It's been a while. So we have a lot of catching up to do. So we're going to talk about a peptide that is very, very popular right now.

[00:02:39] A lot of people are paying attention to it. I've got lots of questions about it. The one thing I didn't list here, um, and I should have, and I just remembered it, is hair growth. So we're going to work that into the discussion as well. Uh, but just for people who aren't aware, what is G H K C U.

[00:02:56] Dr. Elizabeth Yurth, MD: [00:02:56] So, so GFK is really a naturally [00:03:00] occurring peptide in our body.

[00:03:01] It's really just three amino acids and, and unlike some of the synthetic peptides, this is a peptide that we make and like a lot of the important peptides that our body makes. We make a lot more of a more young, so when we're 20 or younger, when we're growing, we have tons of G, H, K we've like, you know, 200 Nana animals per mill.

[00:03:20] And then it starts to actually decline. So 2021 actually starts to drop off. And by the time you're our age, Carl, you know, you have about a quarter of that or less. And so whenever we see these peptides that are very high, when we're youthful and everything's healing well and great, and then they drop with age, we know that they're probably an important component to the whole aging process.

[00:03:39] So, you know, those naturally Korean peptides, they're high. When we're at our best and low and we're at our worst, you'll by the time you're 80 is peptides almost nonexistent and become very, very important. And that's where we sort of have established this stuff that got discovered in 1970s you know, so it's, you know, um, Petra Paccar discovered this.

[00:03:57] He was, now, I think he's 91 if any of you guys ever seen him, he [00:04:00] was still amazing at 91. He's still. Doing research is so insane. Yeah. I

[00:04:03] Carl Lanore: [00:04:03] mean, you must use it himself.

[00:04:05] Dr. Elizabeth Yurth, MD: [00:04:05] I'm sure he uses it. Yeah. And he, and he, you know, he's still out there lecturing. He's still doing research, so at 91 or 92 years old. So it's certainly a testimony to his own stuff.

[00:04:15] But he discovered this back in the seventies and, and we now learn a whole lot more because we, we've sort of found all these amazing things. It does. You sort of listed them at the beginning. But now, and it was all as was maybe pathetic, I think maybe had a little discounted because it was too good to be true.

[00:04:31] Carl Lanore: [00:04:31] Yeah, there's a lot, there are a lot of those. And, and you know, I want to say something. I need to say something you, you made me think of something. So I receive emails from time to time from people who've watched versions of the pep talk and they'll say to me, peptides don't work. Uh, because I took this peptide or I took that peptide and it didn't change anything.

[00:04:54] I didn't notice anything. And I want to just make sure that people understand something that, you know, [00:05:00] peptides are very valuable and they are very effective, but you need to make sure your, your expectations are a little realistic. You know, any, nothing is going to change your condition overnight.

[00:05:15] Nothing. It took you decades to develop your symptoms and it's going to take a while for them to go away. And so I just want to say that because when we talk about these peptides, we talk about them, and especially if I'm the one that doing the talking glowingly, all these things are amazing. But that doesn't mean that taking it from week a month or sometimes even six months is going to miraculously reverse your they all working.

[00:05:37] There are clinical ways to evaluate how they're working by looking at the markers of your disease and how they're changing, but you may not notice anything initially because you didn't notice anything to five and a half, 10 years that you were developing this problem until the symptoms showed up. So I just want to put that out there.

[00:05:54] Yeah,

[00:05:55] Dr. Elizabeth Yurth, MD: [00:05:55] I'm glad you said that because you know, I think we battle this a lot in clinical practice where people, I [00:06:00] think they've gotten adjusted to some medication that gives you the sort of rapid effect, right? You put cortisone in somebody and they have a pretty rapid effect from it. And remember, peptides are very homeostatic or balancing and most things that are homeostatic, meaning they sort of balance things are going to have a much more slow effect to get you where you want to go.

[00:06:16] And so we battle this. People come in and they, you know, these pays money and four weeks later they go, I'm not better. And we, so we really encourage it, but you've got to stick with this stuff. And we make everybody actually at least enrolled in a 12 week program so that we can actually at least show them they're starting to make some results, because at four weeks, I'm probably not going to.

[00:06:32] So it's really important to know anything that's more of a balancing or homeostatic effect. It's not gonna all of a sudden, you know, push you over the edge and have, you have all these dramatic. Healings, but neither will it be dangerous and neither will have all the bad effects that a lot of drugs do.

[00:06:48] So Maddie did mention that, cause I think we fight that a lot.

[00:06:51] Carl Lanore: [00:06:51] Well, and let's, let's also expand on that just for a second longer, cause it's worth saying this. So pharmaceutical drugs are designed to [00:07:00] mask symptoms. peptides are fixing the problem. It takes Walnut to fix the problem than it does to just cover it up with some other problem.

[00:07:08] You know, I received a message today. From a person battling crones disease asking about peptides and, and when I listed some peptides that can be effective. I also said, but you first must remove the insult. Like if you are still eating corn and grains and foods that we know exacerbate Crohn's disease, you could take all the peptide you want.

[00:07:32] It's not going to change. So you know. peptides are great, they're wonderful. There are amazing and exciting, but they're not going to cover up the things that have taken you a decade to carve.

[00:07:47] Dr. Elizabeth Yurth, MD: [00:07:47] Right?

[00:07:48] Carl Lanore: [00:07:48] So let's talk about skin first, because this is an exciting one, especially because. This peptide is about 380 Dalton, which puts it well under the four to 500 [00:08:00] Dalton range for topical and transdermal delivery.

[00:08:03] What are the effects on skin that we say? So

[00:08:07] Dr. Elizabeth Yurth, MD: [00:08:07] I think that's probably where it's, where it's most used, maybe somewhat, unfortunately most used in that realm. Because that is, you know, it's where it's, it's, uh, I think it got his start and I think it's still where we sort of pull it out. And even in my own practice, I, as I was looking at all this, all, all this information on JFK, I was like, wow, we should be using this in a whole lot more diseases than we actually do.

[00:08:29] But we think about it for skin because it has a very dramatic effect on, on helping collagen integrity. So it actually doesn't just sort of hide wrinkles, but it actually is restoring the integrity of the college and it actually at the STEM cell level. So when you look at its effect, it actually is changing the, uh, production of the STEM cells in the skin.

[00:08:48] So you're actually restoring more regenerate or more youthful skin. It also has a really nice effect to protect the skin against oxidative stress. So, you know, sun damage, those types of things. So you're not only [00:09:00] tightening the collagen, I'm actually activating this. This piece, 63 this, this, uh, STEM cells, skin STEM cell, but also protecting against the damage that we're exposed to every day from environmental things like sun or the chemicals that are in the air.

[00:09:15] So there's not really anything else that does that. If you, if you look at that most. Cosmeceuticals. So things that we're putting on our skin, they're not really healing things where our body does. So it's actually, if you look to the differences between young and old skin, that the sexual sort of take time back and it's, you know, it's pretty amazing.

[00:09:35] You have to be diligent with it. You have to use it all the time. There's formulations, there's different strengths of it. Um, and, and. Yeah. But if you're consistent with it over time, people will see, you know, the skin integrity improved as well as they'll see like dark spots go away. So it's been pretty remarkable.

[00:09:51] You can get it. Sometimes we, we are working, it tailor made, used to, but they don't have any more formulation that had it mixed with our, [00:10:00] um, with. Um, our Julian and Faisal, which actually act like Botox. And though you put those two things together and you actually have an almost an instant effect, we're hoping to get that formula back from another, another place soon.

[00:10:11] So there's some really cool things you can do with this. And it's funny, I used to JFK my skin for a long time and started back on it, and, and even my eyelashes actually grew longer, I think just from getting to my, around my eyes.

[00:10:24] Carl Lanore: [00:10:24] Well, we're going to get it. We're going to get into that too. We're going to get into.

[00:10:27] So that's pretty amazing to hair in a second. What is the G H K stand for? I know the CU stands for copper.

[00:10:34] Dr. Elizabeth Yurth, MD: [00:10:34] So it's the, you know, it's the three, um, the glycine, the, the, um, helped me,

[00:10:40] Carl Lanore: [00:10:40] Oh, I know. It's the three amino acids declined, hits the Dean and something else.

[00:10:46] Dr. Elizabeth Yurth, MD: [00:10:46] So it's the three amino acids that make it up.

[00:10:47] Okay.

[00:10:48] Carl Lanore: [00:10:48] Basically. So let's go right to the one. So I first learned about G H K CU. When reading a French study, it was translated into English by a [00:11:00] scientist who claimed he regrew hair. User and he injected it directly into the scalp, which led me to advise people who wanted to regrow hair to buy GH Casey, you reconstitute it.

[00:11:16] Get one of those little microneedling rollers that women can buy in cosmetic stores, squirt it on your scalp, and then kind of do like you're seeding your scalp, and now no one's ever contacted me back and said they've done it. Or that it's worked, but what? What are the effects on, on skin, I mean on on hair.

[00:11:34] So we

[00:11:34] Dr. Elizabeth Yurth, MD: [00:11:34] do do that. So we, we actually, um, you know, have people do a dermal roller on their head. It's a little uncomfortable, I guess, but they dermal their head and then they apply at JFK, you know, copper foam that it's made into sort of a foam or a, you know,

[00:11:51] and you put it over that. Um, and again. Just like it's, it's working for skin. It actually will actually re simulate hair [00:12:00] follicles activity. Again, and this is interesting because a lot of the ways GFK works. Is is more from genetic expression. And that may be how it's helping with Harris is, um, you know, again, restoring some of the STEM cell activity, but it actually is, it's changing some of the genetics so that you actually will, you know, change the genes responsible.

[00:12:20] You know, we know that there's a genetic responsibility for hair loss as well as hormonal and environmental, but that you actually will modify some of the genetics. Involved in hair loss. So that's one of the cool things about this peptide is it's actually changing things at a genetic level, not just, you know, not just kind of, um, you know, maybe stimulating a process.

[00:12:38] It's actually changing the genetics. So it's really super interesting. It actually, it works quite well. You can use it in combination with some other things, like, we'll use it with zinc, find Mulan. Which also helps with the hair growth. So if you use those two together, you can get some pretty marked improvement in hair growth.

[00:12:55] Carl Lanore: [00:12:55] Do you see any changes in hair pigment? Do you see any, like I've heard [00:13:00] people say, Oh yeah, my hair started getting darker and it may make sense because of the copper component.

[00:13:05] Dr. Elizabeth Yurth, MD: [00:13:05] Yeah. I guess that blue tin shit, cause it does have a blue tinge to it because copper is blue. It doesn't have a blue tinge too.

[00:13:10] I could see it potentially particularly a gray hair. You might start to see some darkening of the hair. Uh, I had actually heard that from patients who have gray hair as well, and that may again be more. Stimulating some of the STEM cell activity so that some of the, some of the actually natural picnic comes back in your hair.

[00:13:25] I haven't noticed that dramatically. Uh, but a lot of my guys who are using it are pretty, they do have a lot, a fair amount of hair loss and, and so, you know, they're doing a lot more on

[00:13:34] Carl Lanore: [00:13:34] the, they did notice that you noticed sprouting of new hair, huh? Very

[00:13:38] Dr. Elizabeth Yurth, MD: [00:13:38] much so. Yeah. If you're one of those guys, like, you know, the little patch back here, you can very nicely just then, you know, we'll write over that patch.

[00:13:46] Um. My husband, I just, my husband thinks I'm abusing him. If I had Derma roll his head.

[00:13:52] Carl Lanore: [00:13:52] You know what's funny that, uh, that balding in the back of the head as opposed to the temple [00:14:00] that correlates with heart disease.

[00:14:03] Dr. Elizabeth Yurth, MD: [00:14:03] Yeah. There is some interesting correlation there. Um, you know, because this is more, you know, the androgenic alopecia is more kind of here.

[00:14:11] And this is a little bit more probably, and again, you're actually dating things back a little bit to some of the genetics. There are some, there's some genetics you can look at that correlate with the genetic heart disease. You'll see that. So that, that's interesting that maybe where this GHQ copper, because we know it actually has cardiovascular benefits too, partly by lowering fibrinogen levels.

[00:14:30] So that, that may be one of the correlates that we're seeing is it's actually changing the genetics.

[00:14:34] Carl Lanore: [00:14:34] And interesting. So, um, could you take this. Systemically, if you inject it and have a lot of the benefits we're going to talk about today, even the ones that seem to reach out to the skin and the hair.

[00:14:47] Dr. Elizabeth Yurth, MD: [00:14:47] Yeah. In fact, so, you know, um, this question's been put out a lot, um, because it is well, well observed, absorbed transdermally right. But you would think you get more bang for your buck by injecting it. And so, so you [00:15:00] definitely can inject it. My opinion is you probably will get more systemic effects.

[00:15:04] Injecting it, at least not having to use as much of the volume. We know that transdermal application of anything, more modems, anything, you're going to get some good absorption, but you have to use more than if I subcutaneous injectable. Right? So, so you, you can subcutaneously inject it and then there's some question with, if you subcutaneous inject it, you actually need it down to the copper.

[00:15:23] Because you know, GSK is basically a, um, most of our, our, our copper is bound to albumin. So we have 700 times more albumin than we have VAK. So most of our copper is bound to albumin. And then, so if you just inject chk, there's a lot of excess copper that can be utilized. It combined the copper that's already readily available in serum and go to the site.

[00:15:44] And the upsides of that, we're probably gonna. Reduce the likelihood of any kind of copper toxicity, which I think is very rare. You need a lot of copper for copper toxicity, but it doesn't hurt as much for the injections. Because one of the downsides of the GSK copper is it burns a lot when you inject it.

[00:15:58] If you take the copper out, it doesn't burn [00:16:00] as much. So, so the question is, do you actually need the copper bound to it or not? Or can you just use GFK, have eliminate the bird, it gets the copper it needs from the, from the albumin, and then it know what admin does is acts as a transporter of copper and uhk actually acts at the level to modify the genetics.

[00:16:20] To actually have the effect. So you need both. You need albumin to carry the copper. You need GHQ the effects of the copper. And, um. It's why when we remember we talked about that whole, looking at, at those 10 lab variables that predict age. One of the top ones I remember was Alvin. Yeah, right. Interesting.

[00:16:38] So how does that correlate? Well, we know that as I've been levels dropped, so do you get this changes, modifications, and copper levels, and we now know that copper is low. Copper lows are predictive of neurodegeneration. Kidney DJ's, Liberty generation. So there may be some, some correlation here between, you know, the GSK and the albumin, [00:17:00] both being low as we age, correlating to that copper transport.

[00:17:03] So if we

[00:17:04] Carl Lanore: [00:17:04] suppose it possible, you get just G, H K as a pep,

[00:17:07] Dr. Elizabeth Yurth, MD: [00:17:07] which Cape without the copper. Yes. So you can, so, so the question is who needs the GSK with copper and who needs just the GH K right. And that's where I think we don't really have a clear, a real clear understanding. Cause I think there's some definite benefits.

[00:17:20] And um, uh, just doing the GH K

[00:17:24] Carl Lanore: [00:17:24] I think it sounds to me like I'd rather have just G H K. Because I get plenty of copper in my diet. I eat meat, vegetables, you know, I've got

[00:17:32] Dr. Elizabeth Yurth, MD: [00:17:32] plenty. And you probably find albumin levels cause your whole overall health. I think maybe he has some of these really sickly people who have very low albumin levels and have poor diets that may be doing the GHQ copper together.

[00:17:43] It might be important. And I think in most people who are sort of the people we work with a lot, um, maybe you can get away with just doing the GSK. Yeah. So transdermally you want the copper because the skin doesn't have the copper. So do you want the copper? But, but internally it should be [00:18:00] able to bind the copper it needs and then still have the genetic effects to have all these modifications.

[00:18:04] And so, yeah. And then the dose, I heard dr Picard talk about this and use it. Well, it does anywhere from one to 20 milligrams, which doesn't help so much. I think that the dose is probably somewhere around two milligrams, although. When you look at people's responses, there are people who say when they hit the optimal dose, they had a really dramatic, almost instantaneous effect on like mood.

[00:18:27] Um, cause it has definite effects on anti anxiety said pain for pain. And so there were a lot of people said when they got doubled at like four milligrams sub Q, they almost instantaneously felt better. Their pain went away. So I think there's, there's a still little question about what the right dose is.

[00:18:43] I think a one to two milligram a day dose is probably where most of us would start. Uh, again, you're a little limited by cost and this peptides, it's not cheap. Yeah,

[00:18:52] Carl Lanore: [00:18:52] no, I know. Um, what about cognition? What, what research is out there that shows that this peptide AIDS in cognition,

[00:18:59] Dr. Elizabeth Yurth, MD: [00:18:59] huge for [00:19:00] both cognition.

[00:19:00] And you know, you and I talked some time ago about, uh, era 90 and, and airside bentonite. And so genocide and this drug may have very. Comparable type of facts on neuro regeneration. So both peripherally and centrally. They did a great study out of India, I think it was about two years ago. I'm a  out of India, did a study where they just took nerve fibers, and just by adding the GHQ copper to the nerve fibers, it has significant sprouting.

[00:19:27] Carl Lanore: [00:19:27] Wow.

[00:19:28] Dr. Elizabeth Yurth, MD: [00:19:28] There's been some really interesting studies on Alzheimer's too, where the portions of the brain that were most effected by pet scanning were at, you know, at death. Those patients, when you biopsy that part of the brain had the lowest levels of copper. You know, so, so we know there may be a pretty significant link between dementias and low copper levels.

[00:19:48] Now is that because GHQ levels drop? Right? So  so questions, well, is there not enough copper or can you not get it to the cells because your albumin's low so you don't have [00:20:00] carriers. And you also don't have the ability to, um, have the, the effect of the copper cause has to be bound to JFK to have the effects.

[00:20:08] So if my JFK levels, so if I'm 70 and my GHQ levels are a 10th of what they need to be, then the copper doesn't do me any good. So we know that, that it's not just the copper in the diet. There's been a lot of studies showing it almost an in young people with low copper, right? That there's almost an ms like effect.

[00:20:27] But I had a patient who actually was diagnosed with ms a and she came to me and you know, her brain scan looked like ms, but we got intracellular copper levels on her. They were super, super low. When we placed the copper, her brain scan normalized. It didn't have a little white regions that were suggestive of ms.

[00:20:44] Her symptoms all went away and she was great. So we know that this actually has a very similar effect on nerves, even to things like ms. So low copper is, is a piece. But if I give somebody copper and they just can't do anything with the copper, it's not doing them any good.

[00:20:58] Carl Lanore: [00:20:58] I was gonna ask you, is there, just like, [00:21:00] we know there are people who are hyper absorb iron and, and.

[00:21:05] Yeah. Are there, malabsorbed is, is there a polymorphism for a malabsorption of copper

[00:21:09] Dr. Elizabeth Yurth, MD: [00:21:09] is, I don't know the genetics, but the big group that you'll see are people who have had bariatric surgery. So people have had very atric surgery, don't absorb copper. And I don't think most of the bariatric surgeons tell their patients that.

[00:21:23] And that's why there's this link between very quick surgery and progressive dementia.

[00:21:26] Carl Lanore: [00:21:26] This is amazing. I have a very, very close friend who underwent bariatric surgery about a decade ago. And he is developed socks and gloves, neuropathy, but he also has problems. You know, like he has good days and bad days.

[00:21:41] He'll say, and his, he attributed it to a car accident he had that. His brain was shocking, but I have to bring this to his attention now, cause he may be a melted of copper. Like

[00:21:51] Dr. Elizabeth Yurth, MD: [00:21:51] honestly, you have to bring that to attention. I don't ever see the doctors tell them this, tell them to take B12. They can actually this very special multivitamin, but it [00:22:00] doesn't have enough copper.

[00:22:00] It. This group also, inherently, lots of times has lower levels of gak. Maybe that linked to their obesity. We don't know, but they have lower levels of THK as well. So I think there's a peptide where you give them GFK. In this case, I would give a word the copper, right. JFK with copper subcutaneously, inject it to replace that and hopefully you'll prevent a lot of that.

[00:22:18] And maybe help

[00:22:18] us

[00:22:19] Carl Lanore: [00:22:19] perform. Isn't, isn't too much copper, only a problem in the face of too low of zinc, or am I right?

[00:22:25] Dr. Elizabeth Yurth, MD: [00:22:25] It's that ratio that you need, right? So you need a five to one ratio of zinc to copper. So if your sink levels get too low than that, then the copper levels become toxic. Um. Now you can start and finish.

[00:22:36] The thing about copper toxicity is you'll notice changes well before you have any kind of bad systemic things. Like in those, you know, the, the Luna of your nail, a little nail bed starts treating, you know, getting, getting a little blue. Uh, so you start noticing kind of this bluish tinge to your fingernails sometimes as the Iris.

[00:22:52] So, you know, so those are things that kind of suggest, and probably your, your overall copper levels are getting too high. So it's one of those, you know, [00:23:00] yes. Too much copper bad. Yes. It is. Particularly in the face of too low zinc. But it's pretty hard to get that.

[00:23:05] Carl Lanore: [00:23:05] Well, it sounds to me like if you think you have to too high of copper, the answer isn't to try to cease any copper intake, but to raise zinc intake.

[00:23:14] Dr. Elizabeth Yurth, MD: [00:23:14] Yeah. I wouldn't tell people to go take massive doses of copper. And part of that is the, you know, the Unbound copper is that stuff that's not bound to your, your, your JFK is probably the riskier piece. Right. And so if you have low albumin levels and you have low GHQ levels, and then you're taking massive amounts of copper and what it's not doing any good, number two, that's where you may start to have some issues with it.

[00:23:32] So I think that that. That's one of the keys when we fall. Albumin levels, people who are unhealthy have horrible albumin levels. People who are old have horrible outcomes. So you've got to work on all of those pieces. Um, you know, so that's where this, this, it's not so simply take more copper, but, but, but you are right.

[00:23:49] If you take adequate masses, zinc, it takes a lot of copper to, to ever become toxic.

[00:23:54] Carl Lanore: [00:23:54] And, you know, you know what group of the population have excessively high copper in the face of excessively low [00:24:00] zinc, and that's vegans to district vegans. Um. I've done several shows where vegans have come on my show who stopped being vegans and they talked about like when they got their blood work done that their CAPA was ridiculously high and that affects the brain.

[00:24:14] You start to feel euphoric and woozy and you kinda like, just don't have your balance and stuff. And then they said, once I started eating red meat again, that just went away. Like in a day. So they run the risk of very high copper levels that were out

[00:24:28] Dr. Elizabeth Yurth, MD: [00:24:28] to the low albumin levels. Right? They, most vegans have, have low albumin levels.

[00:24:33] Um, and so, you know, so there's that, that all kind of links together. So we're gonna fight it. And then. Again, the whole thing. Now it that this whole nervous system, destruction, all of this stuff, when you go through all this stuff, okay. Oh wow. It's fixes my skin, you know, regenerate those STEM cells in my skin and wow.

[00:24:52] It regenerates the follicles in my hair. Wow. It, you know, it, it has all this. Kidneys nervous system. That's where I think this PEPs, I got a little bit of [00:25:00] this sort of wrap up of, wow, no Pepsi can do everyday coil.

[00:25:04] Carl Lanore: [00:25:04] Yeah. As soon as you see a pet powder, I could do a lot of things right. But what we do notice, the irony of that is that what we do notice is that these die and try peptides, these really small ones, they seem to have.

[00:25:17] Pleiotropic effects where some other peptides just have a narrow scope of effects. It's almost like the larger and longer the peptide is. The more specific. It's, it's target, but these smaller peptides, they seem to, they kind of like their common denominator for a lot of things.

[00:25:34] Dr. Elizabeth Yurth, MD: [00:25:34] Yeah. I think maybe that's so you can, some of those very small peptides you can probably take back to, you know, from a,

[00:25:40] Carl Lanore: [00:25:40] uh, evolutionary standpoint.

[00:25:41] Dr. Elizabeth Yurth, MD: [00:25:41] It's that point. Yeah. That they were, they were there and they've been maintained from a very small organisms to us, and those are the most important things for us right. Like, like , like the antimicrobial peptide and I L 37 that's been preserved for across every species for, you know, I'm billion years. So why [00:26:00] is that?

[00:26:00] Those are the very important things to our body and this, and this will go along with it. Um, and again, it's, it's gonna come down to, we can talk more about the whole genetic modifications, the number of genes that's changing.

[00:26:10] Carl Lanore: [00:26:10] We're going to take a quick commercial break. If you want to reach out to dr Yukon by going to Boulder, longevity.com there's a.

[00:26:19] A way to message and, and dr earth is licensed to do telemedicine in a multitude of States in the United States. So if you're listening to her and you're thinking, Oh my God, I wish I had her as my doctor, but I live in Florida, I live in some other state. Don't be discouraged. Reach out to her because a lot, what percentage of your practice now has become outside your own state.

[00:26:46] Dr. Elizabeth Yurth, MD: [00:26:46] Boy, it's probably 50% of our patients are from out of state now.

[00:26:52] Carl Lanore: [00:26:52] So reach out, go to Boulder, longevity.com and send a message. Let make sure you let them know that. You [00:27:00] heard about her here on super yum radio. We're going to take a quick commercial break. We'll be right back with more of this fascinating peptide statement.

[00:27:13] Welcome back. We're talking with dr Elizabeth yards, but talking about the peptide  CU, the CU state stands for copper. Um, it's a fascinating peptide and really it really. Which has never truly been popular, popular like it should be. It kind of reminds me of beta alanine, you know, beta alanine was what the Korean speed skaters used when they won eight gold medals.

[00:27:44] Uh, one, one, uh, Olympic season. But it was overshadowed because Mark McGuire was using Andrew  and that was sexy. That was like, Oh, that makes testosterone and no one paid attention to beta alanine. This peptide is like one of those, it's been [00:28:00] around. No one's ever really gone. This is a great peptide, because every time you turned around, there was a growth hormone secreted peptide or this peptide, and it just never really got the, uh, the coverage that it really deserved.

[00:28:13] So it's worth talking about it a few times if we need to. Um, so there's a lot of things that it does, but I also saw some studies that show that it's very, very protective for people undergoing chemotherapy for cancer. You talk about that a little bit.

[00:28:29] Dr. Elizabeth Yurth, MD: [00:28:29] Sure. I think that, again, this is because of, it's it, it has such cellular protection across the board.

[00:28:37] Right. So when, so when you look at, at. Damage from chemotherapy. One of the big things is the sort of free radicals that are formed that that then cause all the oxygen stresses and cause cellular aging and cellular death and all these bad things to occur. So one of the big things that GFK copper does is it acts as a very, very potent antioxidant.

[00:28:57] Again, kind of at a genetic level. So it's actually [00:29:00] upregulating the genes that will, will help to promote. Ways to get rid of these free radicals that are formed. Part of the way it's doing that too is actually its interaction with iron. Um, so one of the things that GFK copper does is it reduces free iron, mostly the iron.

[00:29:19] This bound to ferritin is reduced by about 80% so the free iron released by the ferritin is reduced by about 87% simply by adding GHQ copper on. So we know that when you have high C your my iron levels right, then all of these free radicals are much more dangerous

[00:29:32] Carl Lanore: [00:29:32] to us. That's me. High iron levels may not to be taken this stuff.

[00:29:37] Yeah.

[00:29:38] Dr. Elizabeth Yurth, MD: [00:29:38] You shouldn't be taking this stuff. This really protects against high iron, really does. It really keeps that modulating so that even if your fare tells a well how you're not gonna have the free iron circulating around, this causes cellular damage because it's of that interaction between the free radicals.

[00:29:50] Remember, it's that that free iron. Combines the free radicals to form all these bad toxic elements that if you can, if you don't have that, you won't, you won't have as much problem. So [00:30:00] it's probably one of the big ways it's working. This is helping in this antioxidant properties to, you know, uh, to, to sort of get rid of all the toxins that are formed so you don't get the cellular damage.

[00:30:09] And it also, again, because it actually promotes it, has a very, we used to be a little bit afraid of this drug from a perspective of cancer. Because it's very angiogenic, right? It forms a lot of new blood vessels. That's how it healed neurons. That's how it helps the brain and helps a wound healing. So it forms a lot of new blood vessels and we tend in medicine to shy away from anything that forms a new blood vessels and cancer because that's what you last.

[00:30:36] Carl Lanore: [00:30:36] This is the crazy part about treating cancer. If we did, if we treated other diseases the way we treat cancer, then like for instance, if we treated, um. A disease. We said, well, you know what? Uh, everything that feeds cancer also feeds the good cells too. But we're gonna make the cancer killing the cancer priority, so we're going to kill some good cells [00:31:00] too.

[00:31:00] It's just crazy. You know, we have to focus on killing the cancer and leaving. The rest of the body and tax so it can fight against the disease. Instead, we kill the cat. Like I said, years ago, I said, chemotherapy, treating cancer with chemotherapy is tantamount to burning down the entire house because you have a stain on your carpet

[00:31:23] Dr. Elizabeth Yurth, MD: [00:31:23] right.

[00:31:24] Yeah, you're exactly right. And that's so, so now we actually know, now there's several studies out showing its benefit in metastatic cancer, particularly colon cancer, pancreatic cancer, melanoma. There's been significant studies to show that GHQ copper actually. Slowed or halted the progression of the cancer cells.

[00:31:44] And that's because medical, back to that genetic regulation, that's a genetic modifier. And so we saw that upregulated P 53 and some of the other really important genes for getting our body back into a state of more normal apoptosis of cancer cells. So we want those cancer cells to die. They [00:32:00] shouldn't be alive.

[00:32:00] They, you know, there's something gone awry. Making them continue to reproduce. So what this does is at a genetic level, it puts back the genes that that will help to now kill off the cancer cells the way they're supposed to go. So, and that's why it can do these all these amazing things. It's, it's such a genetic modifier.

[00:32:20] So. Um, are you familiar Carl, with the, um, the MIT Harvard, uh, connectivity map at all? So they developed, like

[00:32:29] Carl Lanore: [00:32:29] we talked about on the show with you at one time.

[00:32:31] Dr. Elizabeth Yurth, MD: [00:32:31] So I don't think so. So MIT and Harvard in Twain STEM put together all this artificial intelligence that looked at all these different substances and their effects on, um, on transcription of, of our DNA.

[00:32:45] Right. And the computers could take all these different substances and look at how they affected. The entire genome almost. And then it would come up with what substances had the most marked effect positively on our genetics, and then they could pick it out and to say, what [00:33:00] were those effects? So there's, there's thousands and thousands of substances that have now been analyzed.

[00:33:04] And JFK, copper is, one of them would run through this connectivity map and it had such marked effects and it was over 500 genes were Mo or positively modified. By GH K copper. So it was one on the top of this, of this kind of connectivity map. It was one of the top substances for positively modified our genetics.

[00:33:24] If we can get our genetics perfect, right? If we have them all positive, everything's being know we were born with bad or good genetics. But as you, you know, you've talked to Tom from Cornell mix, dr C's with, you're talking about the granola mix. Well, it's not our genetics, right? It's how they're expressed.

[00:33:39] So what chk copper does is it goes back at the genetic level and it makes your genes express in a good way. So that's how it's so beneficial, even though it's cutting edge Genesis on stopping cancer, because we get those bad genes to go get the direction right.

[00:33:54] Carl Lanore: [00:33:54] Right? We have a question from, uh, from Natalie Needleman.

[00:33:59] I hope I'm pronouncing [00:34:00] that right, Natalie. Um, could it possibly help people that have hemochromatosis. Yeah, sorry. Yeah,

[00:34:07] Dr. Elizabeth Yurth, MD: [00:34:07] so that's an interesting question. Um, now I think that because in theory you would think it should, right? Because you have this height and the only thing we really know right now to treating hemochromatosis is to have people go blood love, really go donate a lot of blood, but probably they're still buying a lot of that time with high iron levels.

[00:34:22] I do think, and I, and I've never seen any research on it, and I certainly would, would love to sort of. Do some studies on that because I really think it would modify because it would, it would really downregulate that circulating iron that's causing so much tissue damage and liver damage. So I think it would have actually a very beneficial effect.

[00:34:39] But to my knowledge, there's not any research using it.

[00:34:43] Carl Lanore: [00:34:43] So this is, this is just like my mind working. There's no, there's nothing behind what I'm about to say. But if there were ever people who were genetically, uh. Engineered by evolution to be vegans. If the [00:35:00] people who suffer from hemochromatosis, because think about it.

[00:35:03] They, from an evolutionary standpoint, if we could say that this is a, that this is a mistake, we can say that this is a genetic mistake. It's an anomaly, right? But what if it's not an anomaly? What if it's these people had less red meat, animal protein? And they had to survive. So they were selected for people that could extract iron.

[00:35:25] Where we like, I don't extract iron from easily from, from plant sources and most of us don't. But these people were so efficient at extracting iron that when you put them into a modern society where they can eat meat all the time, they end up with too much iron and too much hermatocrit as a result. So it would almost seem like this is an individual who should consider a high plant based diet because they're not going to accumulate as much iron gut.

[00:35:52] Now what do you think of that? Crazy.

[00:35:54] Dr. Elizabeth Yurth, MD: [00:35:54] You know, I think it's interesting is even when you put people with hemochromatosis, and it [00:36:00] kind of depends on the type and the extent. Even when you put them on a super, super low or no red meat diet, you'll still see high iron levels in them. So I think probably they, they certainly probably thrive better than, than.

[00:36:14] That way, but I think there's still, it's a genetic mutation, so I think not, it's probably still a genetic mistake in a sense. Um, you know, it'd be interesting to, to even go back and look at that genetics. And look at what GH copper can may be doing even at that transcription level for those genetics.

[00:36:32] Again, those are kind of cool things. I think this peptide has been overlooked from a lot of medicinal purposes like that. So, you know, we could probably go back to that, that connectivity database and say, okay, what are the genes. That are causing them. There's a multitude of them for hemochromatosis. Are they secondarily modified?

[00:36:50] You can deal with Grenelle mix too, right? So there's this company out of London that now is looking at how your genes are being transcribed. Well, you have these bad genes. If we put you on JFK copper, would they actually [00:37:00] be transcribed differently?

[00:37:01] Carl Lanore: [00:37:01] What's your, we're going to find out, because I just got my chronometer test, um, a couple of days ago and I'm going to be doing it this weekend and I, and you can bet I'm going to start using.

[00:37:12] Uh, JFK, uh, copper. In fact, after I get off the show, I'm going to order some, um, and, and, and I'm going to start using it because I'm really excited. I, you know, it's funny, I wasn't that excited about this peptide before we started talking about it, but now I'm thinking to myself, damn, this, I need this peptide.

[00:37:30] Actually.

[00:37:31] Dr. Elizabeth Yurth, MD: [00:37:31] Yeah, I was the same way, you know, call because I used to supply a ton of my patients, but primarily for skin stuff. We do use it. We do. I think we probably use it more than a lot of doctors do for some, for other purposes, cause we do know it's benefit. But as I, as I kind of was going through and looking at just how incredibly beneficial is peptide, it was, I was like, Jesus, I should really, it's one of the peptides, like, like my girlfriend was agreed to go because I really should probably have everybody on.

[00:37:54] I mean. It's something that is high

[00:37:57] Carl Lanore: [00:37:57] foundation. Yeah. It's a foundational [00:38:00] peptide. It has fat. So my

[00:38:01] Dr. Elizabeth Yurth, MD: [00:38:01] friend, you have to have, you have to have it for wound healing. You have to have it for tissue repair. You have to have it for adequate expression of your genome, which gets, remember as we age, our genetics change.

[00:38:11] Right. And that's, and that's the epigenetics. So it's damage to our DNA now. It makes it express differently. So we can repair that damage and get with this peptide. Could we prevent a lot of aging?

[00:38:24] Carl Lanore: [00:38:24] And we're going to talk about, we're going to talk about the, uh, you've already given me a snapshot into the dosing, but I'd like to hear your opinion a little bit, a little bit later in the show.

[00:38:33] We'll probably wrap when we wrap the show up. How long does it take to start seeing the effects or, or noticing the effects? So my friend bill is listening live on the live audio stream, and he said, what about the heart? You know, does that because he's dealing with some issues right now, and he's a very, very fit guy, but he just got a surprise.

[00:38:50] Is there any benefit to taking GFK copper for the heart? Definitely.

[00:38:55] Dr. Elizabeth Yurth, MD: [00:38:55] So, so it has really significant cardiac benefits, [00:39:00] partly by its effect on fibrinogen, Loris fibrinogen, and we know that that's, that's helpful. Even in people, but a lot of the craic dysfunction is, is oxidative dysfunction, right? And so it's in the fuel and oxygen dysfunction.

[00:39:14] And this is very repetitive to that. Really interesting studies with this peptide and people who have higher LDLs. So we know that people have high LDLs. But they have very low fibrinogen levels. Actually don't end up very LDL. Don't end up very proud mat problematic. They don't end up with with heart attacks and strokes, but people who have higher fibrinogen levels and high LDLs do not do well.

[00:39:36] So yeah. We try and keep fibrinogen levels low in those people, but that's hard to do. How do you keep fibrinogen levels low? One six GSK copper does is it lowers fibrinogen. So you know, so that even in the face of higher LDLs, higher oxygen stress, you don't have the problems. So I think it has benefits for both your patients who have.

[00:39:54] You have, um, you know, Kodak plaque who has, you know, vessel disease and, and [00:40:00] probably some effects from cardiomyopathy. And that's

[00:40:02] Carl Lanore: [00:40:02] why it's, and I'll tell you, I'll tell you where the cardiomyopathy angle comes from. So I read a study many years ago that showed that they took rodents and they did the aortic clamp on them to create the pressure, and they gave them.

[00:40:17] A cardiomyopathy, but the, but the rodents that did not develop cardiomyopathy from the aortic clamp was supplemented with the equivalent of about two milligrams of copper and human room a day. Yeah. And the copper seems to protect the heart from undergoing. Those changes that lead to cardiomyopathy. And so I've always said to bodybuilders that are using anabolics and also training hard, make sure you get enough copper and most of them do in their meat and stuff like that.

[00:40:49] But then again, we come back to this, this kind of curve ball you threw earlier that maybe not everybody absorbs copper very well. Well, here's a great way to get your copper

[00:40:57] Dr. Elizabeth Yurth, MD: [00:40:57] right. And I might [00:41:00] argue that, and not, maybe again, it's not as much. The copper, right as it is that decline in G H K and not. And so even if the copper levels become marginal, right, and you can't get it, it can't have an effect.

[00:41:12] Cause you have to absolutely have to have the  for the copper to stake as effect. Even if you have high, I'll be mineral good albumin levels. So even if you, you're great with your albumin, that's a carrier. You still need the JFK and nobody on their own. Nobody, unless I guess you're some kind of superhuman.

[00:41:28] Um, that has nice. Great. GHQ levels. When they're our age, you just don't. It's one of those unfortunate things, like your hormones and everything else. Everything declines. So again, it's kind of look at EG and we'll put back all the stuff. You know, you'll sit that at peptides are great. We can do a lot with them, but in my mind, the peptides that were there in our body when we were at our best, like 18 1920.

[00:41:51] Well, those are probably the ones that are there. Are we want back in our body

[00:41:55] Carl Lanore: [00:41:55] most important. Absolutely.

[00:41:57] Dr. Elizabeth Yurth, MD: [00:41:57] More so than thinking about the copper. That's [00:42:00] because that is going to be thinking about getting, getting the GH on there so it can have its

[00:42:06] Carl Lanore: [00:42:06] benefits. Yeah. This is, this is really an important peptide.

[00:42:09] It's been overlooked. I mean, I've talked about it before and shows with you and, but we've never really done this kind of a deep dive on it, and this is why it's so important to do. One show about one peptide as opposed to trying to do one show about thousand peptides in jam everyday people's ears. This, you don't get this deep dive.

[00:42:27] We're going to tackle it. I'm sorry.

[00:42:29] Dr. Elizabeth Yurth, MD: [00:42:29] So it's so much more valuable that just go into one peptide and learn all about it because we can't all take 10 peptides and you listen to these shows and I'm like, Oh, I guess I need that and that and that. And. You can be broken

[00:42:40] Carl Lanore: [00:42:40] and you can't have the little nuances where we kind of go off the path and then come back.

[00:42:44] This is the way to do it. We're going to take a quick commercial break and when we come back, we've got more. Stay tuned. I'm just trying to get things lined up here. Here we go. This is the superhuman channel where brawn and brains finally meet.

[00:43:03] [00:43:00] Welcome. We're talking with dr Elizabeth yard, a practices at Boulder, longevity.com you can reach out to her. She is available to help you. What States don't you work with them.

[00:43:16] Dr. Elizabeth Yurth, MD: [00:43:16] Um, right now I have Texas, Texas, a little more for your licensing, but they sort of emergently right now with the whole Cobra thing.

[00:43:23] Um, so there's about, there's about 35 States that we're working with, um, in Texas right now. Included in that. Uh, not in New York.

[00:43:34] Carl Lanore: [00:43:34] No one is New York. Literally Outlaws telemedicine, which I can't believe they do that. Especially in, in,

[00:43:40] Dr. Elizabeth Yurth, MD: [00:43:40] yeah, yeah, yeah, yeah. It's easier. It's probably just to check out, check out our site.

[00:43:47] We can have, we'll give you that.

[00:43:49] Carl Lanore: [00:43:49] So, um. Couple of questions that I just thought of that I want to work in here before we move on. Any value to intra-nasal G H K

[00:43:59] Dr. Elizabeth Yurth, MD: [00:43:59] so [00:44:00] it's interesting. This module actually appears that you've, you put into life was on the form. It might be even well absorbed orally. I've seen some evidence of an and intranasally, but I don't know that anybody who makes the compound.

[00:44:11] Um,

[00:44:12] Carl Lanore: [00:44:12] let me, I did a DIY on how to make your own intra-nasal. I, by the way, I've been experimenting with intra-nasal mulatto tend to, and I love it. I'm going to tell you why I take a hundred micrograms in each nostril first thing in the morning. I don't need coffee. It wakes me up. I literally feel it. It has a nootropic effect.

[00:44:35] Um. By 10 is one natural. My lips don't turn purple. When I inject it, my lips literally turned blue because of the melanin in my skin. And, uh, my tan is much more natural. Even Alisa says it's much more natural. Zero nausea, zero in wonky feeling at all. It's great.

[00:44:55] Dr. Elizabeth Yurth, MD: [00:44:55] It's, yeah, we, you know, we started using Malana Chan as an intra-nasal.

[00:44:59] Um. [00:45:00] It was called nasal tan. We used to get it from London like 10 years ago. We used to use it and we just used before vacation to get a base tan and it works great. So it's interesting that like everybody does as a, as a case injection, it works great as an intranasal. And I agree with you. I thought it worked a little bit better.

[00:45:14] Um, so yeah, I liked, I liked your little, your little demonstration of how to do that. Uh, I know there are some peptides that don't work well intranasally but this one does like one that should be pretty easily used. So it kind of surprises me. We'd have to ask some of the pharmacists why, you know, why they're not making it that way.

[00:45:29] Um, and again, even in a liposomal form, it looks like it might actually be able to be absorbed through, you know, as an oil form. And I've seen some, some patents that are kind of, you know, back looking at it for, for purposes for that. So I think. I think, I think it's  we said to keep working with it.

[00:45:48] Carl Lanore: [00:45:48] Well, dr seeds talks about how it's a powerful and wonderful anti-inflammatory.

[00:45:54] I mean, it works so well, and if you want to avoid brain inflammation, I think, well, why not just deliver it through the nose? [00:46:00] That was my original thinking, the mood, the libido, everything is there except any of the negatives that I hated about it. I don't get dark moles. My lips don't turn blue. I don't get nauseous.

[00:46:10] Dr. Elizabeth Yurth, MD: [00:46:10] Right. And still get some of the new benefits. I, you know, I agree. I think that that's a great way and surprises me that, and I think like, I know you can still buy it, like through United Kingdom, places like that, you can still get it as a neutral forum. So I'm not, I'm kind of surprised we don't do more, more of it here.

[00:46:24] And again, so, so yeah, you're kind of just brought this up. If I was going to talk about the intra-nasal there too, is, you know, from a brain perspective, not only pain, but just sort of a anxiety too. So, so GSK, copper. I, this is one of its really cool uses that we could do. So one of the things we know is say that they just have study, I can't remember the study came out where they, they took healthy young men and they made them copper deficient.

[00:46:50] They took copper, the other diet, and then they measured opioid receptors. So we make our own opioid peptides basically, right? We have our own natural opioids and they dropped 85% if [00:47:00] I called him, was like 80 85% of their opiod receptors or opioid peptides, internal or endogenous opioids. Hi, it's dropped from that by being fed a low copper diet.

[00:47:10] Uh, so they became super, super pain sensitive. Everything they did hurt her, such as skin, and then they fed them back copper and the reserve reverse. So we know that copper has a very, very important effect for our, uh, for pain perception because it has some, uh, some regulation to our own opioid peptides.

[00:47:27] But beyond that. We now know that there's about nine different genes positively regulated that make that the effect pain tolerance by by JFK copper. So again, we're going back to its genetics, genetic effects. We know, I mean that there's that. There's people who are much more sensitive than pain than others, right?

[00:47:44] You can take some people and you could cut their leg off and they hardly wins in principle, they're always in their Winston, your medicine. That's, that's huge. You, you know, and you don't really. Yes. We always go, Oh, those people are wimpy now. They're just genetically, they're more prone to pain. So this may be that sort of bring it back [00:48:00] to, well, optimize the genetics.

[00:48:01] So nine different different genes where we're possibly regulated to make people less pain sensitive by JFK copper. So that's cool. You're actually changing people's genetics so they're more able to tolerate pain. So take these people who have chronic pain, who, what are our options, right? We use all these horrible drugs, um, which now, you know, opioids are.

[00:48:21] Or killing people, right? And so this may be a really safe, healthy option. And it may actually have, if you even did it for a little while, a change in the genetics enough that their pain goes away cause they're just less pain sensitive, but also has a really good anti-anxiety effect. When they did the JFK copper with mice and they put them into these really stressful mazes, the mice, the normal mouse got really fed up and, and, and just shrunk into a corner.

[00:48:49] And the GHQ compromise actually just kept trying, just kept trying. So they had much less anxiety production. They much more motivation using the, so, so, you know, again, win-win, right? Here's the peptide that seems to do [00:49:00] nothing bad. In fact, you look at the negatives to this peptide. Aside from copper toxicity, which we talked about, exceedingly rare.

[00:49:08] That doesn't appear to be downsized. This peptide.

[00:49:10] Carl Lanore: [00:49:10] Uh, we have to answer a question here. Nick Rose says, TaylorMade said intra-nasal melatonin, mulatto tan causes BP spikes. Yeah, it's transient. When you first take the blast, you dopamine. Immediately goes up, live within seconds, and you kind of get a head rush, but then it goes away.

[00:49:27] So it doesn't, it's not, it's not like it raises your blood pressure the entire time that you're under its influence. It raises it for moments after you use it. They found the same thing with intranet nasal PT one 41 it's a transient response to the introduction of this to your brain, and then it just levels out and goes back to normal.

[00:49:49] Right? It's,

[00:49:49] Dr. Elizabeth Yurth, MD: [00:49:49] yeah, it's, it's very, it's very transit. So, and that's an interesting, so one of the things GHQ copper can do is drop blood pressure. And so if you do a whopping sub Q dose, one of the things they [00:50:00] have seen is people rapidly dropped out their blood pressure. He does have a more sustained effect on blood pressure.

[00:50:04] So if you have high blood pressure, that might be another benefit. But if you're very low blood pressure, that may be an issue in dosing it up. And that may be an issue if you did the intra-nasal because again, with engineers, you get a very rapid absorption. And so you may drop out blood pressure a bit.

[00:50:16] It'd be something that has the opposite effects that drops blood pressure. So you, you'd have to watch hypotension with this. Most people, that's not a big issue. I haven't seen anybody. You have to discontinue it because of that. But again, if you, if you're dosing a high subcute was something to watch for.

[00:50:30] Carl Lanore: [00:50:30] Yeah. I mean, even sub Q. Uh, Mo, uh, PT one 41 can raise blood pressure and hypertension and so and so can, it's okay to injected a mulatto tan to a lot of people have, but it's transient. When it's used in a, uh, intra nasal delivery, it rises, it doesn't rise even hours. It rises for minutes after you apply it, and then it drops.

[00:50:53] Now, if there are people out there who have problems. Where they're very sensitive to a rise in blood [00:51:00] pressure. Maybe they've got some thrombosis that they're taking blood thinners for. Maybe they've got some other issues. Then yeah, giving it to them probably isn't a good idea because chances are if you, if you scare them, it's not a good idea.

[00:51:15] They're going to have an event from, from that, but we're not talking. We're talking about healthy people who have normal blood pressure response. It rises for a couple of minutes and then it just goes away.

[00:51:25] Dr. Elizabeth Yurth, MD: [00:51:25] Right, right, Nikki? I think. Yeah, what Carl was saying, so if you had somebody who has uncontrolled hypertension and they're always running with a blood pressure 190 over 110 and now we spiked it up a few degrees, can we have the, we have a stroke?

[00:51:37] Yes. But that's a contraindication. You know, Sacra with people. But there's a contraindication to taking, you know, I'm Sudafed as well, right? So, you know, there's a lot of drugs out there that are going to, if you're right, if you have an uncontrolled situation, are going to make you worse and that there's going be caveats with everything like that that.

[00:51:54] He has a disease process that's really bad. You probably need to be cautious.

[00:51:58] Carl Lanore: [00:51:58] So, um, [00:52:00] you mentioned the word bolus and one of my questions was, so I'm the kind of person who likes to see if things are really working. And the way I do that is the first time I use it, I'll take a really large dose and see if I feel anything positive or negative.

[00:52:15] Doesn't matter to me because I feel something that I know it's doing something right. So one to two milligrams a day. Injected of GH. Okay. You feel like it's kind of like the, the place, the starting point to start to evaluate. What do you consider a bolus? Can I take 10 milligrams and just see how if I notice pain changes or anything like that?

[00:52:40] Dr. Elizabeth Yurth, MD: [00:52:40] So dr picker said, said 20 milligrams, probably you could go anywhere from one to 20 milligrams. So I guess you could bolus 20 milligrams. I mean at night, sit down. And he had rapid drop in your blood pressure, right? So you might want to lay on the couch while you did it. What, you know, what I tend to with my patients is started low and then kind of work our way up until they feel things.

[00:52:57] The things I, I've heard, and I [00:53:00] haven't done this peptide in a big massive dose. Uh, I've only used a very, very short period and most more for kind of a healing of pet facts. But the things I've heard is that when people do hit that sweet spot, they just feel really, like if they had any pain, it goes away.

[00:53:14] They feel very peaceful, no anxiety. Uh, they just feel good. They feel happy, they feel less anxiety, they feel less pain. And that was a very rapid effect. I mean, they noticed that rapidly. So it may have, we can't, we can't measure the genetics effects, right? That's going to take time. Um, and you know, ways to measure it, but you can measure that you feel a little happier and you feel more peaceful pretty rapidly.

[00:53:37] So I think you could very safely, you know, stick 10 milligrams or 20 milligrams in yourself and see what happened. With the caveat being probably that drop in blood pressure, you need to be cautious with. Yeah.

[00:53:46] Carl Lanore: [00:53:46] What is what is rapidly minutes, hours, days. I think it was fast.

[00:53:50] Dr. Elizabeth Yurth, MD: [00:53:50] It was with, Oh, you mean you mean

[00:53:52] Carl Lanore: [00:53:52] how fast, how fast?

[00:53:53] You noticed

[00:53:54] Dr. Elizabeth Yurth, MD: [00:53:54] that it wasn't hours. They felt better. You know, that they had this anti-anxiety [00:54:00] effect that was very

[00:54:00] Carl Lanore: [00:54:00] rapid. So we've discussed pretty much throughout the show, we've peppered that this has epigenetic effects. And as you pointed out, uh, when Harvard and MIT did that research, this was like a top line item that had the most profound effect on the, the largest number of healthy genes.

[00:54:19] Um. So how long for the genetic changes do you think you have to, is this something that, could I take one milligram a day for a long period of time, let's say years? And would it take time for me to see some of these more structural changes?

[00:54:34] Dr. Elizabeth Yurth, MD: [00:54:34] Yeah, I think it probably depends on which genes, right? So certain genes aren't even modify more easily than others.

[00:54:40] It's going to. Um, so I think that that, when you ask that question. That probably depends on what genes you're following. I think that typically when we, when we, I don't know that we have the answer to that cause we don't have anybody who's measuring the epigenome every month to see if I did this one to change it.

[00:54:57] It's expensive as he used to do that. [00:55:00] Uh, you know, SomaLogic who is a proteomic company. Remember R R R. Do you know, in terms of their Epic, you know, in terms of our proteins can modify because proteins are going to change first. But those are, you know, you're gonna see this expression, and this would be the easiest thing to measure rapidly.

[00:55:14] But I don't know that anybody, anybody's done enough ongoing every month, every two weeks, whatever it is to see when that change occurs. I think we just sort of all go on, well, six months. Um, I suspect there's some, some changes that occur much more rapidly than that because you can put people. In situations, you know, the opposite extreme into a stressful situation for as much as a week and actually see changes in their proteomics.

[00:55:35] So I suspect that the same thing can happen with the good positive changes. So I do think, and that's, again, it's too bad you can't do economics test every week when you make a change. Right. So, you know,

[00:55:47] Carl Lanore: [00:55:47] to get an IRB and some funding, that's all.

[00:55:51] Dr. Elizabeth Yurth, MD: [00:55:51] That's the hard thing is these tests are, you know, they take a long time.

[00:55:54] You know, they're, they're expensive. We need quicker and easier measurements. I do think, you know, measuring

[00:56:00] [00:56:00] Carl Lanore: [00:56:00] by idea. Yes. I liked the idea of proteomics because I never thought about it, but you're right. Because we're seeing, we're seeing the downline effects of the genetic changes then, right. Exact measure, those quickly

[00:56:09] Dr. Elizabeth Yurth, MD: [00:56:09] and as quickly right there, they're more, they're more easily measured than, than the Epogen genome.

[00:56:14] So, um, but I do suspect we can, we'll test people again at six months. That's not in being much more useful to be able to get the data more rapidly. So I suspect that probably you would start seeing some epigenetic changes pretty rapidly. I mean, maybe weeks, but I don't know the answer to that.

[00:56:30] Carl Lanore: [00:56:30] So let's wrap this up by talking about the dosing again so that I know the dose can be anywhere from one to 20 milligrams, but we're talking about taking on a daily basis.

[00:56:40] So the dosing should be wide on a daily basis. A starting point.

[00:56:45] Dr. Elizabeth Yurth, MD: [00:56:45] Well, I think probably, I mean that the recommendation is usually one milligram. I think probably two milligram, probably for most people is a better dose. It's become very expensive. You know, I mean, you'd be talking about 300 plus dollars a month to do two milligrams a day.

[00:56:59] So we usually [00:57:00] prescribe it at one milligram a day. Uh, but I think that probably, if you look at this peptide a little higher is probably going to be a better dosing. And maybe even looking at like four milligrams a day, it's just, it becomes. It's too expensive for most of us to continue at that level. So I think he said, okay, realistically what can we do that people might be able to say for, for a longer period of time, you're probably going to be looking at one milligram.

[00:57:22] Um, and that's one, two milligram dose. But do I think the ideal dose might be higher than that? Yeah, I do.

[00:57:28] Carl Lanore: [00:57:28] So from, from the research on idiopathic short stature, we know that giving a child. Uh, when you're trying to correct a short stature, the same dose of growth hormone day in and day out is not as effective as taking that same exact dose on a weekly basis and splitting it up in more irregular.

[00:57:51] Uh, uh, injection. So instead of giving them, let's say, let's say 25, uh, I use a a week as the goal, you know, let's do 20, cause that's easy for me to do [00:58:00] numbers, but instead of giving them, you know, X X, I'll use a day consistently, seven days a week. You know, you go Monday, Wednesday, Saturday, and you're still getting the same amount total, uh, I use per week, but the growth is greater.

[00:58:15] Could it be that. A lot of peptides are like that since growth hormone, technically as a peptide, and maybe their magic would be like, instead of taking, uh, uh, two, two milligrams a day, maybe take four milligrams every other day or something like that. Any, any ideas on that?

[00:58:31] Dr. Elizabeth Yurth, MD: [00:58:31] Yeah, I don't know. You're right.

[00:58:33] The very many pamphlets I think are better off either cycling on and off and changing things up or, you know, going on and off them on a daily basis. I don't know. Because if you're looking at this from a more. That this pipeline seems to exert its, uh, is most marked benefits by its genetic effects. We used to sort of blame it all on copper.

[00:58:53] You know, everything was good at dead with copper. We kind of don't think that anymore. And so if we're kind of looking more at the [00:59:00] epigenetic. I don't know that maybe a more regular dose all the time would, wouldn't, wouldn't be better. Cause we're not looking for such such a, you know, receptor. It does this, it's more, it's very constant regulation of the copper levels that's changing our genetics and change our genetic expression.

[00:59:17] But I don't know the answer to that. They don't know that. Don't we have the research done with these such injections in this way and what is the best dose for this? We just don't have it.

[00:59:26] Carl Lanore: [00:59:26] Right. This is fascinating. You know, I, like I said, I've known about gak forever. I've ignored it forever. I've talked about it before, but I literally, I'm going to see about getting myself some, because this sounds like a peptide.

[00:59:41] I definitely need, you know what I mean? I'm going to be 62 next month. And, uh, I, and I'm not gonna lie and say, Oh yeah, I feel like I'm 35 I don't, and I want to do things that I know will improve how I feel and how I function. And this sounds like I'm going to be using it for a while and see what happens.

[00:59:59] Dr. Elizabeth Yurth, MD: [00:59:59] Yeah. [01:00:00] Yeah. I think Nietzschean adds my basic peptides.

[01:00:03] Carl Lanore: [01:00:03] I know this is, this is one of those, this is the vitamin C of peptides. This is like a foundational thing. You don't think about it. You're just taking it all the time. That's it.

[01:00:10] Dr. Elizabeth Yurth, MD: [01:00:10] Funds, we can get it. Uh,

[01:00:12] Carl Lanore: [01:00:12] Boulder. longevity.com is the place to go. If you want to work with a physician who is forward-leaning, understands medicine, but also is looking to be on the bleeding edge of helping people and, and everyone that.

[01:00:24] Works with doctor earth, uh, sees the benefits that they're searching for. I'm just starting a 20 day run at a pretty high dose. Natalie, can you post what your dose is? Please? Just curious. And even if it's, can't wait to see what happens, just post the dose. I'd like to know what I've pretty high doses. I just like to know.

[01:00:44] But anyway, you can go to a Boulder longevity. Uh, dot com reach out to dr earth, uh, and, and see results and not results that you get from pharmaceutical drug that you, you know, you shouldn't be taking costs. They're hurting you. Thanks for being here today. Really.

[01:01:00] [01:01:00] Dr. Elizabeth Yurth, MD: [01:01:00] Hey guys. Want to, I'd love to teach to educate people.

[01:01:03] I think you guys have heard the. You know what Carl does, and, and you guys go in spreading the word because it's so important. We have a whole arm for building longevity. That's all just education. It's called human optimization Academy. You can go there and listen to some talks. Um, you know, so that you learn this stuff.

[01:01:18] Uh, you know, we, I do a lot of webinars, you know, through Facebook watch for those, because I think, you know, this is, uh, a place where we have to build from, from you guys, from Carl bringing this stuff to you. You guys spread it to your friends because this is going to be how we sort of changed the world.

[01:01:33] So thanks.

[01:01:34] Carl Lanore: [01:01:34] Thank you very much for being here today and we'll have you back soon. I think the next talk we're going to, we already picked out, we're going to, we talked about it off the air and this is going to be one about something. So ironically, this one will attract more listeners because it's about fat loss.

[01:01:50] We're so vain, right? I don't remember. I remember Billy Billy crystal when he used to imitate, uh, Carlos, uh, Ricardo. Mattapan, you look [01:02:00] marvelous and we all know it's better to look marvelous than to feel marvelous. That's what we are. I take care of, have a great weekend and we're going to take a quick commercial break and when we come back, I'm going to wrap up the week.

[01:02:11] For those of you who've been here. And touch. Stay tuned. Evolution just got kicked up a notch.

[01:02:29] so couple of things I want to cover real quick and let everybody go. Have a good weekend, Natalie. Thanks for sharing that. Uh, those of you who are sticking with us through the break, Natalie is using five milligrams a day. I just ordered something. And I will be probably starting out at four to five milligrams a day as well.

[01:02:46] I'll be glad to compare notes with you, Natalie. Um, I want to talk about this peptide for a second. Um, because it's, it's not that they're not [01:03:00] all created equal, uh, the gak peptide, I just found out it's, uh, I get my peptides at peptide sciences. Most of you know that. And there is a coupon code that you can use SHR for 10% off your order.

[01:03:17] And they don't pay me anything. I pay money for my peptides and I just, I just know that they're reliable. They put mass spec assays of every peptide up on their website. People always say to you, how do you know you could trust them? Well, they actually have third party testing done and they actually sell to universities and labs.

[01:03:33] Um. They make their  peptide to the exact specs that dr Lauren Piccart Picard. He's the leading expert on gak. Uh, he, he dedicated his entire career to studying it and they actually worked with his lab to perfect the production of this, this peptide. So it's important to understand [01:04:00] this because this may be why some peptides work and some don't.

[01:04:04] There is some nuances to making these peptides. Uh, so if you go to peptide sciences.com use the code SHR and you'll save 10% off your order. Also, I'm so excited. So I've been, I've been depressed. Yeah. I didn't, haven't trained at all this week. And I feel different. I don't feel good. I feel old. I gotta be honest with you.

[01:04:24] I don't feel old when I'm training every day. And it's no wonder that there are people out there who are depressed about this pandemic. It's not just the, for me, it's not the staying in, cause I'm not in, I, I've been doing the same things every day forever. I, you normally I leave the house, go to the gym and train, leave the gym, come to the studio and work, leave the studio, go home and eat a meal with Alisa, get back to work.

[01:04:50] I watched one hour of television five days a week. That's it.

[01:04:57] I don't have the time. The only thing that's been [01:05:00] missing is going to the gym for me, and I thought I was going to crush it. I thought, Oh, I'm just going to, I bought an Airdyne a D six so I can do high intensity interval training. I already have power blocks, kettlebells, bands. I have a lot of stuff at home to train.

[01:05:14] It's just not the same. I love going into the gym. I love. It's for over 20 years. It's been my morning regimen and it's just been stolen from me. And so I don't feel really great right now. And I know June 1st our governor, he thinks he's well-meaning, but he's not. He's making more people sick and he's harming while people, because more people kill themselves by being broke right now.

[01:05:41] But. He said June 1st is when Jim's will start to open up again. And for those of you who missed this week shows you ask any virologist if we sh if we locked down in place, if everybody stayed in their own house, if they, the government gave them all the money they needed, they didn't have to worry about losing their houses and their jobs and the government gave [01:06:00] the companies all the money they needed that they didn't have to go out of business.

[01:06:03] If we stayed in that house for six months, hell, a year when we came back out. Would the virus be dead? They'll tell you, Oh no, it'll start spreading again. See, viruses don't die. When you contract the virus and you build up an antibody, chances are you still have the virus. You just don't feel affected from it anymore.

[01:06:26] So when you come in contact with other people, they get the virus. So you can't wait this virus out. You can't hunker down and say, well, we'll get a kill it. It doesn't die. It will start to spread again. This is why as soon as we open up the country, the idiots are going to start to see people dying. And yes, death is an unfortunate part of life, but if you look at who's dying.

[01:06:55] All of them are either fall into a couple of different classes, very, very ill people. You have [01:07:00] heart problems already. You couldn't run six blocks if you had to do it to save your life, you're going to die from this virus. But the other people that are dying, as we know now that it's coming out in nursing homes, are elderly people 80 years and above, and they would die from the flu.

[01:07:16] That's why they are the largest part that go out and get the vaccine, but they still get the flu those years that they get the vaccine. Um, the, the reality is that the reality is that we cannot wait this virus out. And the longer we take this approach, the longer it's going to be with us because once we get out and about, and the virus goes through our population, and sadly it's going to kill some people.

[01:07:39] Yes. Hey, maybe it'll kill me. My, my daughter called me this morning because my son wants to come and visit and she's telling me, Oh, dad. What are you crazy? You know, you're in that age group. I know I'm in that age group, but I'm not going to die from this virus because I have a strong heart, strong lungs.

[01:07:57] I'm fit. This isn't going to kill [01:08:00] me, and so, and I'm confident of that. I know that. Plus, I know that Zipcar, myosin will knock it out of you. I'd get two Z packs from my doctor. I'd take him 10 days in a row. It would be gone, but. And how do I know that? Listen to my shows. I've done shows on it, but anyway, we can't wait this virus out.

[01:08:19] The only way we're going to end this plague, if you will, is to get back to life, and sadly, some people are going to die now. If you're one of those people that's high risk, you're unhealthy, you're unfit, you have comorbidities, then you have to take special precautions. You should stay home, you should wear masks, you should do all those things, but the rest of us don't have to.

[01:08:40] We don't have to. So it's very, very misguided. Our governor is doing the same thing. And, uh, he's not gonna open the gyms til June 1st and it's just stupid. He, you know, we have politicians who don't understand science. Has he ever interviewed a virologist and asked him, will this go away if we stay in doors long enough?

[01:08:58] The viral has said, Oh no, it's not going to [01:09:00] go away. It's going to, as soon as we start moving around again, it's going to come back. So I've been pretty sad and I've been a little depressed that I gotta be honest with you. And so I did something to, to help with my depression. And it's arriving today.

[01:09:12] It'll be here at five 30 that's my, my new motorcycle right there. Yes, sir. I haven't had a motorcycle since I was in my early twenties. And before that, that's all I had. I didn't have a car. I used to borrow my father's call when I had to use a car, but other than that, I had a motorcycle. And motorcycle has been my first choice of transportation for the early years of my adult life, and I'm not going to use it.

[01:09:39] To commute back and forth to the office. I mean, maybe I will once in a while if it's a beautiful day, but what I'm really looking forward to is me and Elisa getting on it and going out into the country. We have such beautiful countryside here in Kentucky. It's ridiculous. So, uh, we bought this motorcycle so that we can go do things and have fun and be adventurous, but it will be here today at three, [01:10:00] three 20.

[01:10:00] Now. It should be here between five 30 and six. Uh, and I'll be, unfortunately, it's raining today. Um, but it may have stopped raining since I've been in here, but I have, uh, miraculously I feel excited. Again, I don't feel depressed about, about the, uh, about the covert virus and the, and the shutdown. So I'm excited about that.

[01:10:19] Ben Turner Dixon has a comment. Let's read it here.

[01:10:25] I appreciate you sharing, as always called just wrapping up around of two milligrams daily for 50 days of GH KC, you feel great and skin has dramatically improved. Thank you for sharing this, Ben. Um, hard to say if the gak directly or is it directly as I've been on some other compounds as well. He's like me.

[01:10:49] That's why I can never tell what's working. Um, I feel. In order again, and, um, I'm trying to read this here. He can't attribute it to the [01:11:00] JFK for being the way he feels because he's on other things, but he's going to order it again after a few months and go for a higher daily dosage. I'd love to hear back from you, Ben, after you try that.

[01:11:11] I just placed my order during one of the commercial breaks, um, from peptide sciences and I am excited to get it and I'm probably going to start out. Uh, at about two milligrams a day, just to see for the first week, but then I'm going to go up pretty fast. I think I'm going to be where Natalie is. I'm going to be at five milligrams a day and.

[01:11:31] If it makes me feel great, I'll keep buying it and taking it at that dose. What the hell? I mean, there's lots of other things I can waste my money on. I don't waste my money on booze. I don't waste my money on lots of other frivolous things. I definitely don't waste my money on clothes. Any of you who've been watching me for any amount of time know that I just wear the same clothes over and over again.

[01:11:50] I am never going to be accused of being a clothes horse. That's for sure. Those things aren't important to me. Knowledge is important to me, and family [01:12:00] and life. Those are the things that are important to me in that order. I look, um, it's been a fun week. If you haven't listened to some of the shows this week, they've been great.

[01:12:09] Go back and listen to them. We have a great week planned for next week. Of course, Elisa Profumo is booking all of my guests now, and that's why we have so many great interviews. Keep in touch, share the show, change some lives. You could be responsible for helping people and changing lives by sharing the show, uh, of course.

[01:12:28] And, uh, and uh, visit the website, superhuman radio.net to find out what's going on. Sign on to our newsletter. We don't. Barrage people with information we send out only when we have something good to talk about, like an existing show and that's it for this week. Have fun, stay safe, and uh, don't be afraid of covert 19 live life.

[01:12:51] That's the first step. Live life [01:13:00] .