[00:00:00] Carl Lanore: [00:00:00] welcome back to another episode of super human radio. Today is August 12th, 2020. Uh, we're going to be talking about two important topics today. First, we're going to be talking about how kind of a dial can be used, uh, to help people suffer, left less damage, um, from contracting COVID-19 well, SARS Cove, too, whatever you want to call it.

[00:00:24] You know, we talked about 25 hydroxy LL three seven, the effects of sun exposure, and even vitamin D supplementation all the way back in March on this show, before anybody talked about it. And once again, we're going to be bringing you some really exciting and breaking information, um, about how to deal with some of the worst symptoms of this virus.

[00:00:54] Later in the show, we're going to expose some BS, science, you know, science is for [00:01:00] sale today. Um, it's very sad. It used to be, uh, there was a point in time where scientists had cordial discourse and discussed things without digging their heels into the sand and defending their positions, uh, beyond the scope of the science that they had available.

[00:01:21] And I'm there is, has been an assault. On red meat for many, many years. Now, we're finding out that it's really not bad if you're not eating processed foods, but a study was just commissioned by a company that makes fake meat, um, to show that fake meat is better for you. And we're going to look at the science and we're going to discuss what really it shows and what it doesn't.

[00:01:51] We first have to thank our title sponsor legendary foods. The website is legendary.com. The code is SHR 10, [00:02:00] for 10% off everything there. If you're a low carb person, if I'm managing how much protein you get and reducing the amount of sugar in your diet is important to you, but you still want to snack.

[00:02:13] You still want to feel like you're cheating, but you're not. The website is eat legendary.com. The code is actually chart that's HR 10. They have a, uh, uh, something called a tasty pastry, which looks like a pop tart tastes better than a pop tart, but in fact has less than one gram of sugar. Uh, three, nine grams of high quality high leucine protein.

[00:02:37] And between three and four impact carbohydrates, you should get them for yourself and your kids, especially if your kids are getting ready to go back to school. Without further delay. I have my guests join me and that is dr. Babak.  how you doing? 

[00:02:55] Dr. Jack Yu: [00:02:55] I'm ready. Thank you so much.

[00:02:57] Carl Lanore: [00:02:57] And no one can see your mouth move.

[00:02:58] So raise your hand, dr. [00:03:00] Bavon is in the back. Thank you. And dr. Jack, you is in the front, you know, we have to get used to not being able to see people's mouths when they talk and, uh, And it's a it's, it's something that I, a little nuances where I, when people talk on the show and they're wearing a mask, I have to say, Hey, you know, no one knows that you you'll have to, uh, you'll have to raise your hand and let us know.

[00:03:21] So anyway, this is a interesting study. The, um, research looked at the effects of CBD or cannabidiol. On, uh, inflammatory process process experienced during, uh, SARS Cove to why? Why, why, why did you two look at this? Why did you, uh, look at this? What, what, what was, uh, uh, any previous research that made you go cheek?

[00:03:48] Hm, this might be interesting. Let's check it out, check it out.

[00:03:52] Dr. Jack Yu: [00:03:52] Uh, sure. Uh, first, uh, thank you again for having us, uh, Um, since 2014, uh, [00:04:00] we, I hope I'm clear my voice

[00:04:02] Carl Lanore: [00:04:02] perfectly.

[00:04:03] Dr. Jack Yu: [00:04:03] So since 2014, uh, we have been, uh, working on the, uh, beneficial and potential of the, uh, CBD cannot be dial and medicinal cannot use in general in, uh, several, uh, disease model, uh, and mainly inflammatory diseases, including.

[00:04:23] Uh, tumor, uh, ischemic kidney, and also chronic wound. Uh, so we had, uh, enough data and supporting evidence that CBD has potentially, uh, is a very good anti-inflammatory agent. And, uh, since, uh, uh, the COVID-19. Uh, the main problem is the, uh, uh, basically hyper inflammation and kind of inflammatory diseases.

[00:04:53] So it was very plausible for us to, uh, knowing the potential of CBD. We [00:05:00] related it to the. Um, inflammatory responses in the COVID-19 and we thought it would be a very good idea to test it, to see if we can see any, uh, beneficial.

[00:05:13] Carl Lanore: [00:05:13] Now, the really nice thing about this discussion, this discussion is that CBD is available without prescription and just about every state in the United States today, which means that if it does have.

[00:05:25] Protective effects. Uh, it's not going to be controversial. You'll be able to go and buy it. You don't have to explain why you're buying it so that that's, that's a really important distinction between the things that are being talked about in the mainstream media and this right. So, uh, maybe, um, like to answer this question, what's the pathway that CBD seems to suppress inflammation.

[00:05:49] Is it the traditional cycle? Oxygenase. Uh, Cox one Cox two suppression, or is there something else at work here that maybe looks more like Omega threes, which have [00:06:00] a, a genetic switch, uh, to shut down inflammation

[00:06:06] Dr. Jack Yu: [00:06:06] I'll get us started, but, uh, again, thank you. But the answer to that question is that we don't really know.

[00:06:13] Um, there are many, many potential steps, uh, including the. Barking of the iron panels, the interference of the signaling detecting the virus all the way to the activation of a releasing of these inflammatory mediators. Uh, we know at least a half a dozen potential steps, but I like to, uh, just, uh, clarify one point.

[00:06:48] We did not use SaaS cup to the active virus itself. We do. I have a biosafety level three, a BSL three or four. [00:07:00] So what we did is we bypass the, uh, uh, the bowel infection that say, this is the virus. Once it gets into the cell, if we its genetic material during the duplication, it forms this double stroke.

[00:07:16] How strong the body, the text, the double strand RNA. So we use a synthetic double strand, RNA, deuce, lung inflammation, and lung damage. Then we rescue it with CBD and we did document the, uh, the beneficial effect. I also want to emphasize that, uh, the initial phase of the viral entry. Is associated with massive suppression of body surveillance and defense, because we probably give this kind of a, a microbial invasions all the time.

[00:07:55] So the vouchers evolved a very elaborate set of mechanisms to [00:08:00] suppress our defense. So even though CBD is commercially available. It will be a very, very bad idea to give an anti inflammatory at the time when the virus is already suppressing the body's response. It is during the second phase, when all of a sudden you go from not able to respond to too much, uh, responses.

[00:08:30] So even though CBD is commercially available. The timing of its administration is critically important.

[00:08:38] Carl Lanore: [00:08:38] Okay. So let's address that. So is it safe to say in the initial stages where, um, we already have a suppression of inflammation, you're probably asymptomatic at that time, but then you start to develop symptoms and the symptoms could be difficulty breathing, uh, you know, the, uh, traditional [00:09:00] pneumonia type.

[00:09:01] Symptoms, would that be the time to introduce, uh, the CBD? We

[00:09:07] Dr. Jack Yu: [00:09:07] believe so we're currently using the real virus, uh, in collaboration with a UGA. And your point is an excellent one. We'll we'll probably be looking at, at the beginning of the symptoms. That's when the symptoms such as fever, difficulty breathing.

[00:09:26] Those are the signs that the body is kicking in the inflammatory reaction. And we will probably want to administer CBD to induce anti-inflammatory effect at that time. But the actual timing is critically important. So

[00:09:44] Carl Lanore: [00:09:44] lots of things have been shown since, since the whole discussion of cytokine storm, which is a word that we've used on the show for over a decade, because it is apparent in several conditions.

[00:09:58] We now [00:10:00] realize there are lots of things that can modulate cytokine and inflammatory responses, everything from melatonin to glutathione, uh, in some cases, high dose. Liposomal vitamin C and intravenous vitamin C, and the list goes on and on and on. So my question to you is, do you see CBD becoming part of a stack that's administered to people to combat the tissue damaging effects of over-responsive the immune system?

[00:10:33] Or do you see it as a standalone? It can do the whole job by itself.

[00:10:39] Dr. Jack Yu: [00:10:39] Well, uh, that's a excellent question, actually. Uh, no, I don't think it can do it by itself. I mean, based on our, uh, uh, finding, however, uh, CBD is a excellent immune regulator. So, but it has an [00:11:00] innate advantages, uh, of it take advantage of so many things in all, but one of them is.

[00:11:06] Uh, already built in endocannabinoid system, which basically the CBD indirectly affects it and it is widely spread in our body. So, uh, it is natural. It, uh, basically, uh, it's a good, uh, immune regulator, but no, it needs a, um, uh, in harmony and it needs a synergistic function. Really cool. B. It's not by itself because, uh, uh, able to do what we need really different, but in conjunction and in, uh, association with other, uh, agents.

[00:11:45] Yes. I think it is a very powerful, and I did, I'd like to mention funding. We. Have to differentiate between immune suppression and immune regulation. So CBD is [00:12:00] an immune regulator. That's the good thing about it. It doesn't completely switch off. It basically brings it down to a, uh, adequate level of what,

[00:12:11] Carl Lanore: [00:12:11] so it can still re can still respond.

[00:12:13] It's just not over responding.

[00:12:15] Dr. Jack Yu: [00:12:15] Exactly.

[00:12:16] Carl Lanore: [00:12:16] Okay. How was your study design? Did you do this in a Petri dish? Did you do it in rodents? What did you do? Uh,

[00:12:24] Dr. Jack Yu: [00:12:24] no. Uh, we use animals. We use, uh, mice. Uh, the specific time is black six. So we give the double stranded, the synthetic RNA on day zero to induce this body's response to the, um, The the, we call the pant PANP pathogen associated molecular path.

[00:12:48] And that's a signal that the body look for. So if you have that, you know, that there's, uh, an infection going on. So after day two, that the, after the second [00:13:00] dose, we start with the CBD, the animal receive a total of three doses of the challenge. The poly, I see a acid, which is a synthetic, uh, uh, RNA. And then we give them, uh, the CBD by day three without the, uh, the challenge.

[00:13:18] And then they go on for several days. Uh, after about a week, we, uh, checked for that clinical signs because when people have a acute respiratory distress syndrome or Hey RDS, they cannot get enough oxygen into them. Um, uh, the blood streams, and you can detect that by using a POC, SOC similar. So in our model, the oxygen saturation goes down by 10 percentage points, which for a human will be down to about 80, 90%.

[00:13:51] Um, in this, uh, mice, they are, they're almost two 80. And, uh, the CDC cautions, if you are a voter saturation goes below [00:14:00] 94% and then they also have increase in cytokines. Uh, They have a lot of white cells and actually date in the lungs. And, uh, if you can imagine, you need to have a very thin membrane to allow the gas, to exchange these, uh, fluids build up in their air SACS.

[00:14:21] We call the Abiola and the air exchange become problematic. That's basically, uh, pulmonary failure.

[00:14:30] Carl Lanore: [00:14:30] How did the rodents receive their therapeutic doses of CBD and what they daily were they multiple times a day, once a

[00:14:39] Dr. Jack Yu: [00:14:39] day at about two hours after the, uh, the, the, the double stranded RNA, we give them in their belly called  injection.

[00:14:50] We're giving them a five milligrams per kilogram weight.

[00:14:55] Carl Lanore: [00:14:55] So, so when you do intraperitoneal, you're, you're, you're bypassing the, [00:15:00] the, um, the action of eating, right. And because you want a precise dose delivered, but it's still going into the stomach and being digested, just like something that would have been eaten.

[00:15:12] Correct.

[00:15:14] Dr. Jack Yu: [00:15:14] Uh, it's not in a stomach in the stomach. You go through the, I just try and then everything is picked up and it has to be filtered by the liver. First. There's a first pass effect, right? Just like you take Tylenol. It has to go through the liver. And that is a little different than if you give Tylenol by intravenous route.

[00:15:36] So we give IP, so it doesn't have to go through that. Liver is picked up. And it is, uh, it's more of a, a systemic dose rather than a oral dose.

[00:15:49] Carl Lanore: [00:15:49] So is it similar to intravenous? And when you go intraperitoneal, you're bypassing digestion and that's and thus bypassing the liver, but you're still putting it [00:16:00] into, um, the intestines, correct?

[00:16:03] No. Oh, okay. I misunderstood

[00:16:06] Dr. Jack Yu: [00:16:06] inside this cavity called the courage annual abdominal cavity. And we put that medicine into the space. That's between the bowel and the abdominal wall, and then by the peritoneal membrane through the liver. But the majority, this is almost equivalent to a, uh, intravenous, but, uh, injecting into the Tel required very, very tiny gauge needle.

[00:16:35] And there's a much more challenging. And given IP is a much simpler, more straightforward method.

[00:16:42] Carl Lanore: [00:16:42] Was the, um, what was the, the, uh, drug used an isolated CBD? Was it full spectrum? What, what exactly was it? We

[00:16:54] Dr. Jack Yu: [00:16:54] use their isolated CBD. Uh, it was isolated. Uh, three, [00:17:00] we have a study going on. We are trying to get broader spectrum and full spectrum CBD also, but the data we have on what's published, uh, we thought with resolve with it is.

[00:17:12] Uh, isolate.

[00:17:14] Carl Lanore: [00:17:14] So it was free of the turpines and all of the other active ingredients found in full spectrum. It was just the various CBD portions of, uh, of the hemp. Right.

[00:17:25] Dr. Jack Yu: [00:17:25] Absolutely. Okay.

[00:17:26] Carl Lanore: [00:17:26] Yeah. And that that's important because there's a lot of discussion out there today, as I'm sure you well know, you know, full spectrum is better, uh, you know, uh, isolates don't work.

[00:17:37] And so clearly this is interesting because you used an isolate and it's doing its job. That's very, very promising. Um, a listener, a viewer says that his frustration is that there's no standardization out there. Um, And on the consumer level, uh, does from the same manufacturer seem to vary, uh, with the, uh, uh, with, with the amount of [00:18:00] CBD in them.

[00:18:01] Um, so that, that's another thing that people need to consider if you're listening to this and you're thinking, Oh great. You know, my grandmother just got it. I'm going to go down to the store and buy this CBD product. That's sitting on the shelf. We, you really have no way of quantifying the potency of that.

[00:18:20] Uh, as compared to what was done in this laboratory, correct?

[00:18:24] Dr. Jack Yu: [00:18:24] Absolutely. This is one of the, uh, frustration that we share. Um, the, the Connecticut dial research or the cannabis research in general has this problem because it's not, unless you get it from a very reputable or, or, uh, uh, uh, from that. That manufacturers and sells a very high grade, almost pharmaceutical grade.

[00:18:54] Uh, can that be die or you have no idea. And there's [00:19:00] several reasons. One is the legal issues. Uh, two is the questionable source that you cannot verify. And as a result that the, uh, the supply, uh, is often limited. And the purity, uh, is often questionable. So hopefully one day we will elevate this whole field.

[00:19:23] Just like if you go buy a, a tablet of Tylenol, right? No, you're a sentimental thing. And, uh, the way we use this is, uh, as a pharmaceutical, so we know the purity and we can, uh, have, uh, The repeatable, uh, quality from fax to batch. Otherwise you cannot, uh, you cannot depend on what

[00:19:49] Carl Lanore: [00:19:49] you're getting. So with that being the disclaimer, what was the dose given to the rodents?

[00:20:00] [00:19:59] Dr. Jack Yu: [00:19:59] It's five milligrams per kg,

[00:20:02] Carl Lanore: [00:20:02] five milligrams per kilogram. Yes. And I know there's a, a human equivalent formula, but do you know what the human equivalent formula would be? A milligrams per kilogram?

[00:20:16] Dr. Jack Yu: [00:20:16] It'd be about the same since it's per kilogram. So you will have a a hundred kilogram person that will be 500 milligrams or 0.5 grand.

[00:20:26] It's a pretty hefty,

[00:20:27] Carl Lanore: [00:20:27] yeah, that's a big dose because most of the commercial CBD products, the entire bottle maybe only has 2,500 milligrams of CBD. So that's a, that's an expensive bottle and, and. D D this application would acquire that bottle to be good for five doses. And that's it. So, yeah, that's a pretty big dose.

[00:20:49] So one

[00:20:50] Dr. Jack Yu: [00:20:50] of the 10 right now is through to do the pharmacokinetics to see what is the optimal dose and what is the, of course, when we [00:21:00] give it to people, we're not going to stick it in their Hertz, any old cavity. So we're looking at, uh, The most likely a waste of administering. This is probably through any Hiller, a puff like you do with prevental.

[00:21:16] Carl Lanore: [00:21:16] Well, and that, and that, and that would, uh, offer an opportunity because we know that the, these cytokines, well, this virus, this virus prefers the, the lung tissue. We know that. And so by doing that, yeah. Thank you. Are you shutting that off? Um, we know that, that this virus prefers to reside in the lungs. And so that would cause a great opportunity to deliver this drug right to the lungs where the greatest concentration is.

[00:21:46] So that would be great. We are,

[00:21:49] Dr. Jack Yu: [00:21:49] we are working, we are working with, uh, uh, one or two groups, uh, hopefully. And when we start working with UGA, uh, university of [00:22:00] your job, uh, that's been plan basically to do it through the inhaler.

[00:22:05] Carl Lanore: [00:22:05] That's brilliant. So, um, When the dose was given, how soon after did you see the changes occur that the increase in blood ox, uh, the, the changes in inflammatory response in the lungs, was it immediate or did it take days?

[00:22:26] Dr. Jack Yu: [00:22:26] It took days. It did. Yeah. Yeah,

[00:22:32] Carl Lanore: [00:22:32] no, no. Please take your time.

[00:22:35] Dr. Jack Yu: [00:22:35] Okay, but we first start in if that's the day for so day

[00:22:40] Carl Lanore: [00:22:40] four. So after administering it continuously for four days, that's when you started to see it.

[00:22:45] Dr. Jack Yu: [00:22:45] So it gives for two doses of the CBD because we gave three doses in total every other day. So.

[00:22:55] Day forward. Wouldn't be

[00:22:58] Carl Lanore: [00:22:58] okay.

[00:22:59] Dr. Jack Yu: [00:22:59] And what is [00:23:00] the four, which is off the second doors? Obviously we need, we saw a significant effect.

[00:23:06] Carl Lanore: [00:23:06] Now, now CBD is thought to have an effect on the central and peripheral nervous system. Uh, did you, did you observe anything else in the road since that. Um, like why were they less likely to, uh, move?

[00:23:21] Did you, did you challenge them with amaze? Did you, uh, put males and females in the same cage? Did they do anything else that would identify that the CBD was also working in other ways?

[00:23:35] Dr. Jack Yu: [00:23:35] There's the question of rodent behavior is a lot challenging one. We have built, uh, offering conditioning cages. So that we can observe, uh, the behavior.

[00:23:46] Uh, one of our project was looking at using Canary dial for postoperative pain with me, but to manage your pain is not that easy. And we use only male mice. [00:24:00] So we could then tell, uh, other behaviors, but just actively I think, uh, the full spectrum, my seem to be happier in other experiment compared to the, uh, The more pure preparation of a CBD.

[00:24:17] There are many, many compounds, the turpines and even just a can maybe dial family. Uh, and it'd be Chrome there at least a thousand of these. Um, but we don't have to, to really do that. We need an infrared cage to track how much they move. They're they stay, whether they stay in the center or the corner of periphery of the case will be, this will probably be part of the, uh, the next study design.

[00:24:48] Carl Lanore: [00:24:48] Did it change eating habits? Did these rodents have ad libitum a chow available? They ate when they wanted to. And did they change, did it change their, their consumption?

[00:24:58] Dr. Jack Yu: [00:24:58] Well, After [00:25:00] the, uh, infection when we infected them. Yes, very briefly. But after the administration of the CBB, uh, they went back to normal very quickly and they were eating and drinking.

[00:25:13] Carl Lanore: [00:25:13] Well. We're going to take a quick commercial break. When we come back, I've got lots of more questions we're talking with dr. Babak Gabon and dr. Jack, you from, uh, your, your, your, with the university of Georgia, correct? I'm sorry. I think I'm at a university, right? Okay. Thank you. And, uh, and, and we're going to cover, so I've got more questions.

[00:25:31] I know the audience is very interested in this, you know, um, the, these types of discussions are very promising because there's a lot of people out there who are looking for ways to. Not get damage from this virus, this virus permanently damages the lungs, especially when a ventilator is used because the inflammation causes the lung tissue to be less pliable, less expansive.

[00:25:58] And then the, and the [00:26:00] ventilator forces the lungs to expand and contract. And a lot of people who were ventilators were used, they will have lifelong problems. Now that even though the virus has gone, they'll have lifelong problems. Uh, with breathing. So this is, this is very, very interesting to me. I'm going to take one quick commercial break.

[00:26:14] We'll be right back with more super human radio station. You were listening to the superhuman channel. Don't hate us because we feel good.

[00:26:26] Welcome back. And we have a question from a live viewer. Uh, Tony PKS is accent asking. What about THC? Uh, I recall skimming over an article about sativa and some anti COVID benefits. Is there any evidence that THC may provide any of these benefits we see in CBD?

[00:26:49] Dr. Jack Yu: [00:26:49] We didn't use a THC. So we, we are in no position to, uh, to answer that question.

[00:26:56] Carl Lanore: [00:26:56] And plus, you know, THC is a lightening rod today. I mean, some States [00:27:00] have some legalities, others, it's still illegal doing research on something that's illegal. And, you know, 60% of the country is probably a feudal, uh, because even if it does help. Most people aren't going to be able to get it anyway. So it doesn't matter.

[00:27:16] So what about reversal? Um, as I said, going into the break, we know that some of the, uh, damage done to the lungs appears to be permanent. Um, the lungs just can't recover. And as a result of that, uh, people who survive COVID, uh, some not all, but some who survived COVID they end up with lifelong. A problem.

[00:27:40] Lung problem. Did you see a reversal of the damage, uh, in the presence of the, of the CBD

[00:27:49] Dr. Jack Yu: [00:27:49] before a full, a shortcut experiment? The answer is yes, but, uh, the, uh, ARDSM or the acute respiratory distress syndrome has, [00:28:00] uh, by textbook three phases. From extra dative to proliferative to five Brodick. As you mentioned earlier, that you do have that, uh, fibrosis.

[00:28:11] So I, I think you never get back to the way you were in surgery. We have a one truism, a scar once made is made forever. We don't regenerate. We repair, we, we make scars and the scars in the lungs just like scars on the back of your hand is not as pliable is not the normal, uh, scheme. So I think it's a matter of how hard you look.

[00:28:43] You will always find a residual. If fact, depending on the degree, some have a much worse others, not as much, but, but the damage is, uh, very likely to be, uh, going on for a [00:29:00] substantial amount of time.

[00:29:02] Carl Lanore: [00:29:02] So when we look at COVID, uh, or SARS Cove too, we know that earlier the treatment, the better the outcome. So perhaps in the future research, do.

[00:29:15] We can look at, um, intervention, introduction windows and see if in fact, the sooner you start, the less lasting damage there is, would you think that that would be a possibility?

[00:29:33] Dr. Jack Yu: [00:29:33] Yes. Yeah. Um, it is. We want to fight the virus. We want the body's innate and adaptive immune. Um, to, to, to, to stand up and get rid of the virus, but want to do so with the minimal amount of collateral damage, which is not a easy thing, because the matter of which army wins, the battle, the battle field is

[00:29:58] Carl Lanore: [00:29:58] destroyed.

[00:30:00] [00:29:59] Interesting. I like that.

[00:30:00] Dr. Jack Yu: [00:30:00] Yeah, but the, uh, the, uh, I think the best time is to, to intervene before the massive release of, uh, say. This thing called  beta, which is a very, very inflammatory mediator. Um, B okay. The suppression of, uh, or the, the, the reestablishment of the regulation. This is a very planning to the complex, uh, system.

[00:30:30] And I think a as not the Babin said earlier, it's going to require a lot of, uh, adjustment, not, I don't think, as you said, one single medication is going to do that. It will require physician teams of physicians to, to really help the patient, uh, recover and, uh, return to, to a state of, uh, it could Librium.

[00:30:57] Carl Lanore: [00:30:57] So God, I'm sorry, dr. Bowman.

[00:31:00] [00:31:00] Dr. Jack Yu: [00:31:00] Exactly. Um, the, uh, you raise a very good point. The timing, just to add to what dr. You said in timing is extremely important because immune system has three jobs in our body is it has to detect attack unclear. So we have to let the immune system to detect. At tad. And then for the clearance that when these intervention with an agent like CBD can be very helpful to make these clearance meaningful and green down that tone of the attack and pans down and go back to the homeostatic balance.

[00:31:42] Basically immune balance. Yes.

[00:31:44] Carl Lanore: [00:31:44] So the, the, the, the fact that we have an endocannabinoid system and the fact that we actually have cannabidiol or cannabinoid receptors, um, indicates to me that throughout evolution, we were exposed, uh, to these [00:32:00] plants. Perhaps we consume them the way we consume lettuce and broccoli today.

[00:32:05] At one time we consume them just the way the mitochondria, um, Became a co-conspirator of ours. You know, we, we know that the things that are make up our tissue they've had part of they've come into our journey throughout evolution. So do you, do you think that the fact that CBD works in the first place is because we have an endocannabinoid system, number one?

[00:32:33] And part two of that question is, are we ignoring the cannabidiol cannabinoid receptor and its importance in our daily life by not consuming plants that have CBD in the morning?

[00:32:49] Dr. Jack Yu: [00:32:49] Uh, let me clarify. Um, we, if you look at a worm, do you see elegance? They [00:33:00] have the, a receptor as well, and they ever consume, uh, okay.

[00:33:05] That'd be dial. So I think a more, uh, appropriate way to look at it is, um, you have a key that will open a lock and that regular key, that indogenous signal the assistant is the endocannabinoid signaling system that the body ordinarily uses and is a very, very ubiquitous. It just so happened that this plant, the cannabis plant who do some compound that can fake happened to open the same lock.

[00:33:42] But I don't think, uh, we are sitting here just waiting to eat this plant. The plant compound is sort of like a counter fit, a us dollar bill. You think that all a bill, you go to the store. Yeah. You can fool them for some time, but it's [00:34:00] not the real thing, right? It does. It does, uh, do the mimicry. Good enough.

[00:34:07] You look at the, uh, the structure, the real thing looks like it, but I don't think, uh, we, we, we were designed to eat the stuff because if you do the genetic, uh, tracing. This, this material has been, that the endocannabinoid signaling system has been around for a long time. Okay. Probably predates, wait, wait, wait, creates the appearance of a cannabis sativa.

[00:34:36] Carl Lanore: [00:34:36] So, and, and so what you're basically saying is it's very similar to phyto estrogens in plant that we have estrogen receptors and there happens to be something in the plant world that also mimics that, but it didn't contribute to the fact that we have estrogen. Okay. Yeah, I get it. That's good. Absolutely.

[00:34:57] So, um, [00:35:00] Do we know which there are two, uh, CBD receptors, correct. Uh, kind of a dial one and two is that

[00:35:07] Dr. Jack Yu: [00:35:07] and Sydney too.

[00:35:09] Carl Lanore: [00:35:09] Do we know which receptor is responsible for the beneficial effects and, and dealing with the, uh, exacerbated inflammatory response from ?

[00:35:21] Dr. Jack Yu: [00:35:21] So the CB one and CB two are. The part of the endocannabinoid and the cannot be system, but they are not the direct receptor for CBD.

[00:35:34] So CB one. Yes, it is, uh, a react with the THC. However, CBD does not react with either one. I'll ever get all other receptors like shape one, like GPR 55. Those are, uh, there are several receptors which are, uh, uh, reacting to the CBD, but [00:36:00] when CBD activates those receptors, dose evasion indirectly affects the CB too, and CB to get activated on the, uh, immune system, basically.

[00:36:15] So indirectly it affects indoor cannabis system, but neither CB one knows TB do is the receptor for CBT.

[00:36:26] Carl Lanore: [00:36:26] That's very fascinating. I would have never guessed that. So w w where, where in our body is cannabidiol made as part of the endocannabinoid system? Is it made in cells? Is it made in the liver? Is it made in random tissue?

[00:36:41] Do we know where, where, where these, these molecules are made?

[00:36:45] Dr. Jack Yu: [00:36:45] The molecules that the body makes, it's not a can maybe dial it is called a anatomize, which is a long chain fatty acid, very similar to the prostate gland in the dormitory mediator. [00:37:00] Peter's um, uh, we don't make, cannot be dial. The, the compound we make is called, uh,  ethanol and mind, which is similar.

[00:37:14] That's what the, uh, the fake dollar come same. We don't make CBD. We make the real thing. And the CBD looks like the real thing. There are several of these, we call them endo cannabinoid and that amine is the big one. Uh, and also to ag is the other one.

[00:37:36] Carl Lanore: [00:37:36] So fatty acids, you're saying, is that what you said?

[00:37:39] They're fatty acids.

[00:37:41] Dr. Jack Yu: [00:37:41] It will launch in fatty acid at a modified. And, uh, the interesting thing is that a lot of them have, uh, two, uh, though. So they are dials and they have a tail that has five, uh, uh, carbon chains called the Pentonville

[00:37:56] Carl Lanore: [00:37:56] pale. Okay. [00:38:00] So, uh, I don't want to veer too far off of this, but since this may be in your wheelhouse of study.

[00:38:06] So if we in fact, make these molecules, and in fact, these molecules have a variety of beneficial effects and in regulating immune response, uh, affecting pain, affecting mood, um, does dietary fat intake play a role in. Purdue and supplying the donors, substrates that become these fatty and these long chain fatty acids that have this wonderful effect.

[00:38:41] Dr. Jack Yu: [00:38:41] The answer is, uh, a qualified. Yes. Um, if you chronically suppressed that intake, you are going to get into trouble after several months. Um, That is a very important component. Uh, but the, [00:39:00] the cell membrane, it's all made of, of a fatty acid with a polar head. And, uh, so when you have a normal store of a fatty acid, you will use that.

[00:39:13] But if you use all of them, Then you will be in trouble because you will break down your own cells in the muscle, in the heart, in the liver to provide the necessary essential fatty acids. So absolutely you need to have some fat if you continuously don't have a fat, if somebody is on the pure protein diet.

[00:39:34] Month after month, the you get into pro protein poisoning and you will start to break down the own body to produce the necessary, uh, essential launching fatty acid. So yes, you do need to have some fat intake. Absolutely.

[00:39:51] Carl Lanore: [00:39:51] I think Stefan proved that in his, uh, after he lived with the Inuits and then he tried to re reproduce the diet, but he [00:40:00] ate only lean.

[00:40:01] I think he was at Bellevue hospital for that, uh, for that research and, uh, He broke down. He, he became, uh, uh, emotionally unstable. He felt sick. He felt weak. He started to lose muscle and they couldn't figure it out. And then it was only when he started to incorporate fat back into his diet that he feel good again.

[00:40:21] And then he realized, Oh, the Inuits, they eat a lot of fat along with, you know, they don't eat any vegetables, they just eat meat and fat. So I, I see what you're saying. That's an interesting, very, very interesting. Um, we're going to take our last commercial break. And when we come back, I want you to tell us what is the next step in your research?

[00:40:41] Because I think this is very, very fascinating. Stay tuned. We'll be right back with more superhuman radio.

[00:40:49] Is the superhuman channel evolution just got kicked up a notch.

[00:40:57] welcome back. We're talking with [00:41:00] dr. Ababa Bavon and dr. Jack, you, they are from the medical college of Georgia at Augusta. We're talking about recent paper that they published looking at the effects of CBD on the inflammatory response. Oh, suffered by the lungs during SARS Cove to COVID-19 clearly there is some value to understanding what this molecule can do.

[00:41:24] Um, yes. Fascinating interview really is, and I'll tell you what else is even more fascinating. So, you know, I'm not sure super intelligent, but about fats and fatty acids and stuff like that. But in fact, stearic acid and palmitic acid, uh, both precursors to the. A fatty acid that you spoke of that have this, um, marvelous effect on the endocannabinoid system.

[00:41:49] And obviously those are two fats that are highly discouraged because they're saturated fats that people are told, well, no, don't eat saturated fat. When in fact there may be some value [00:42:00] to saturated fat consumption. You never know that that debate is still going on. We're not going to get into that. So.

[00:42:07] What does future research look like to you to help get a better understanding of the value of, uh, CBD? Uh, not just in this particular incident, uh, of inflammatory lung, but other diseases, even, maybe even CLPD. I see this maybe being something valuable and, uh, and cop D what do you think.

[00:42:35] Dr. Jack Yu: [00:42:35] Uh, in the two, uh, pathways, one is, uh, more clinical. Uh, we won, uh, through, uh, IRB, uh, using a randomized control trial to confirm that the observed effect in mice will happen in human as well. And that is a more prolonged, uh, more involved process, [00:43:00] obviously. Um, but we are actively pursuing that. And then the other side is to try to understand more the mechanism.

[00:43:09] So this is a component that's looking for, the scientific underpinning of this, and the other one is more like engineer. You just want to make sure it works. Um, how we work is not as important as the fact that it works because the literally thousands of people, uh, dying every day. Um, so. We want to hurry that process up, uh, with appropriate, uh, precaution.

[00:43:39] And then, uh, from the, the biology perspective, this is a fascinating process. So the first thing we need to do is to use the real virus since the real virus does not engage the mouse, uh, Viola, numerous sites. So. Oh, [00:44:00] collaborator is using a transgenic especial, genetically engineered, uh, uh, um, mouse strain that has a human, uh, angiotensin converting enzyme type.

[00:44:13] So we've got to fact the, the, the transgenic, uh, East to West the, uh, the virus, they were going to go try it to add the initial phase after the infant watch and try to wake up the immune system. And using the immune potentiator and then once the, uh, the, the hyper inflammatory, uh, stay, start to look like it's going to happen before the cytokine storm, or even after the cytokine, during the cytokine school to rescue it with a CBD.

[00:44:47] And there are other, uh, applications, as you mentioned. Uh, one, one would be to, uh, we, we have started that work even before the, the pandemic is to [00:45:00] use, uh, CBD as a postoperative, uh, pain relief medicine, as you know, that there's a massive, uh, uh, A narcotic, uh, overdose crisis. And, uh, just about every seven minutes somebody dies of, uh, uh, opiate overdose.

[00:45:19] So CBD is almost ideal. It relieves pain. It makes you want to move more quickly is important because after surgery, if you don't move, you tend to have more complications. It increase your appetite is an orexin. Uh, it has a ability to surprise nausea and vomiting. So that's one of the things that actually got us started looking at a wound healing and, uh, in fact have a CBD.

[00:45:50] Um, so we were very excited and, uh, there are a lot, a lot of work to be done and, uh, give it to doc and, uh, [00:46:00] exactly. Just to add a few words there. As you mentioned and that doctor, you mentioned, uh, it is not only, I mean, yes, this is very important in the higher urgency for the COVID-19. However, the, uh, impact is not only of that.

[00:46:18] That's really the other inflammatory diseases. We have looked at the ischemic kidney. Uh, we have, we have used on the ischemia. We have used on the tumor models and we are actively doing it. And so, uh, those are the venues. Really. We want to extend our research and continue our research like that.

[00:46:42] Carl Lanore: [00:46:42] So Tyler Cypress says, but why not use full spectrum, which is often better as it contains turpines and other parts of the plant that can also be helpful to the human body yet.

[00:46:54] Why, why aren't you using a full spectrum product? Why are you just focusing on a CBD isolate?

[00:47:00] [00:47:00] Dr. Jack Yu: [00:47:00] We, uh, we, we are using the, uh, studies, uh, ongoing study. We are using the whole spectrum and draw the spring. We are comparing them. We started with the isolate because, uh, when you do the research and thinking for the mechanism, As you have less variables, it's easier for the basically on

[00:47:22] Carl Lanore: [00:47:22] to assigned, to assign assigned to this particular molecule of this effect.

[00:47:27] Yeah.

[00:47:28] Dr. Jack Yu: [00:47:28] So when we have the proof of concept, then yes, then we will extend it to the fullest spectrum. And then we have people in full spectrum. We have also to come. Compare do and compare with, uh, each of those valuable thought important. So, uh, it's a very good point. We are doing it. We are comparing different, uh, form of the CBD and, uh, uh, uh, if you to just stop.

[00:47:57] Carl Lanore: [00:47:57] What about boswellic acid, Andrew Scarborough, [00:48:00] who was watching the show from the UK. He says, I like to use boswellic acid, similar effects and less expensive to get quality product. The swell like acid have similar effects as CBD.

[00:48:13] Dr. Jack Yu: [00:48:13] I don't know. I'm not aware of that compound at all.

[00:48:19] Carl Lanore: [00:48:19] Interesting. Okay. Alright. Well, look, I want to, I want to thank you for your research. I want to thank you for coming on the show and talking about it. I it's valuable to get this information out into the public. So people understand, uh, that there are other things out there that could help. Um, uh, you know, there's this, um, this viruses has hurt a lot of elderly people, especially they are the least likely to recover from it.

[00:48:46] So the sooner we can give them access to something that can. All sways that the dam damage from being done in the first place, the better it is. And again, I mean, I'm not [00:49:00] suggesting, and you're not suggesting that people go out and buy CBD and treat people who have covered with it at the same time. It that's a personal decision.

[00:49:08] If somebody wants to do that, then God bless them. Let them do it. If it, if it benefits them. Great, one thing is for sure, CBD is generally regarded as safe now. Uh, large doses don't seem to hurt people. Uh, so it's, uh, it's, it's one of those things that, uh, is available for people to consider, I think, and, and physicians, two physicians could, uh, direct their patients to, to, to try this.

[00:49:31] They could. Yeah. Thank you very much for being here today. Both of you, dr. Dr. Thank you. Take care. Take care of

[00:49:40] Dr. Jack Yu: [00:49:40] people. Thank you.

[00:49:41] Carl Lanore: [00:49:41] All right, so we're going to take one quick commercial break. When we come back, we're going to talk about a study. That claims that the beyond meat burger is better for you than beef.

[00:49:56] The study was done and [00:50:00] published by Stanford medicine. And interestingly enough, guess who funded the study beyond meat? So we're going to dig into this in a second. Stay tuned. We'll be right back with more super human radio.

[00:50:23] welcome back. We've talked on the show quite a bit over the years about how science is for sale today. And it really is. You can find science and scientists who would come up with research to back your personal opinion. No matter what it is, a science has become more like religion than science. So it's no surprise to me that I saw this study.

[00:50:51] Alyssa sent this to me. So this is from Stanford medicine.

[00:50:58] Plant-based meats [00:51:00] improve some cardiovascular risk factors compared to red meat. Let's talk about the study, first of all, um, The study used a group of individuals. I think it was 30 altogether who ate one way for eight weeks and then ate another way for eight weeks. And they looked at blood markers and stuff like that to assess the effects.

[00:51:20] Now they talk about chop meat, ground beef in the beginning of the article, but then throughout the article, they just refer to the subjects, ate two meals a day. With a red meat or the beyond meat burgers. And they did that for eight weeks and then they switched and did the other thing. So if they were the group that ate beyond meat twice a day for eight weeks, then they switched and they became the red meat eaters.

[00:51:55] They never said the type of red meat they were eating. Never. It's [00:52:00] interesting to me. If, if you're claiming that beyond meat is better than chop meat or ground beef, then shouldn't, they all be eating ground beef. Uh, some of them ate chicken. They did note that, but other than that, they just lumped everything in together as raw red meat.

[00:52:18] Now, this is a problem for me. This has been a problem for a long time. Whenever we talk about meat studies always say, red meat is bad for you. But then you find out that they consider bologna hotdogs, you know, processed meats, red meat, and they're not red meat. They're not, if anything, they're gray actually.

[00:52:42] And red meat to me is steak. Um, chopped meat, you know, uh, what else? Different cuts of steak and chop meat. That's red meat. I mean, even pork is considered the other white meat. They try to [00:53:00] differentiate themselves from red meat for a reason. So what they discovered were two things and whether or not the research proves anything at all, as far as cardiovascular risk.

[00:53:17] Okay. Beyond meat is loaded with lots of garbage. Right. Beef is beef. That's it? That's it. That's just beef. Ground beef is beef. That's it? You know, beyond beef meat has a coconut oil in it. As the fat has a variety of plant based products added sodium, you know, it has fillers to add texture, blah, blah, blah.

[00:53:45] And while they are trying to focus on sodium. That the only thing that's really questionable about beyond beef? Well, beyond meat is that it, that it is, um, has a [00:54:00] lot of sodium in it where beef doesn't, that's really not the real problem, not to be honest. So they made sure to point out that beyond meat had no say so in the research they gave the grant.

[00:54:15] And they didn't take part in designing the study and that would make you feel good until you read this one part

[00:54:24] senior author whose last name is Gardner is a long time vegetarian and a staunch proponent of eating whole foods with particular emphasis on vegetables. So the senior author is basically an anti meat person. Of course, he's going to, he doesn't need any oversight by the company to say, Hey, we want the outcome to be this way.

[00:54:50] He's already in their camp. It's probably why they authorized him to do it. Let's be honest. No one is going to give money to a group without [00:55:00] having a sense of whether or not the research is going to come out in favor for them. Because most legitimate groups who do research will say. You're giving us money to do this.

[00:55:11] Now we're going to publish this paper, whether it comes out good for you or not. And if you're a company who stock is going through the roof, would you take a chance like that to have them go well, you know, there was no difference on or get it wasn't any better than red meat. You're not come on. We're not fools.

[00:55:31] Right. Follow the money. So. Red meat was what they were looking at. They didn't determine whether or not these were whole cuts of red meat, how the meat was processed. Was it grass fed? Was it naturally raised? There's only two things that they looked at in this study. And the first one is a complete loser, in my opinion, it's [00:56:00] TMAO.

[00:56:02] Yeah. They said that TMAO was lower in the group that was eating. The beyond meat product twice a day for eight weeks. We know now that TMAO is not causative of heart disease. It seems to correlate. And there were two good studies a couple of years ago that showed that depending on your mic, biome, eating meat may produce too AMA or not.

[00:56:30] So TMAO is more an indicator that your gut is messed up. Then meat is causing problems. And so it's quite plausible that your messed up gut is what causes the heart disease over time. Or it could be that your messed up gut correlates with the crap food you eat day in and day out, which has nothing to do with meat.

[00:56:53] So TMAO is a very, very weak. Weak, uh, correlate. And [00:57:00] every one, they even put it in the study. At this point, we cannot be sure the TMAO is a causal risk factor or just an association. They had to say that cause that's what science says, but yet they put all their eggs in that car. Oh, it reduced TMAO. So that was the one thing that they said.

[00:57:19] Was a proof that it was better for your heart. The other thing they said was there was a slight, a significantly significant, but slight drop in LDL cholesterol in the group eating. Okay. The beyond me twice a day, as opposed to the quote unquote, whatever red meat they were considering, red meat. Again, LDL is not, is not.

[00:57:43] We know now that cholesterol is not directly indicative of heart disease. Inflammation is we also know that carbohydrates promote inflammation to a greater degree than fats or proteins. [00:58:00] And there's only, there are no animal carbohydrates. There are no animals out there that are high in carbs. It's all plant based stuff.

[00:58:07] That's high in carbs. There was one thing that surprised them. There was a modest drop in body weight in the eight weeks that the guys and gals who ate the beyond meat versus the quote unquote red meat. But that doesn't mean anything you and I know that people have cancer, they lose massive amounts of weight.

[00:58:33] You think they want to lose that weight? No, most of it is w is muscle weight. So it's very plausible that the group for the eight weeks that didn't get any meat, they lost muscle. If they would have done a DEXA scan, some sort of qualitative body composition analysis and said, and it was all body fat, then I'd say, wow, this is really interesting.

[00:58:57] That's interesting. But just losing two [00:59:00] pounds over the course of the eight weeks. It doesn't tell me anything. It could have been two pounds of valuable muscle, but see this group doesn't put any value on muscle. They like the mainstream. So be prepared, be prepared for this study to start being discussed.

[00:59:18] Oh, Elisa said it was grass fed. Are you saying that the meat was all grass fed and was it all whole cuts of beef, Alyssa? Please put that up there. But I come back to my point, TMAO is not indicative of heart disease and all scientists agree that it's a weak correlate at this point in time. And we really don't know what it means.

[00:59:40] There is research out there that shows that your gut produces higher levels of TMAO, not just the consumption of meat. So if your gut is jacked up, that's where the TMS email was coming from. The other thing is. Losing two pounds of muscle. Isn't a good thing. And they needed to quantify that in this [01:00:00] study.

[01:00:01] But lastly, always follow the money. The guy heading up the study, he's a vegetarian slash vegan. He's completely anti meat. So GRA uh, um, beyond meat is saying, well, we had no impetus. We didn't know how this was going to take. You knew how it was going to turn out. You would not have funded this study if there was even.

[01:00:21] A 1% chance that it was going to come back and say your product stunk, you know that and anybody with a brain knows that. So I'm calling this science BS. I'd like to see a nonpartisan, a group that has no vested interest in it. Head up by meat eaters, too. Do this research and find the same outcomes.

[01:00:46] That's what I'd like to see. But we won't see that because beyond meat won't fund that study, I guarantee it. So be prepared. You're going to start seeing this in the media very shortly beyond meat reduces the risk of heart attack. [01:01:00] It's not true. It's not true. It's not true. That's it for today. And thank you for watching.

[01:01:06] Share the show. Please share the show. Always share the show. Help people learn more. And not become a fools and preyed upon by what the mainstream messages. I will see you tomorrow with more superhuman radio. Thank you for watching today. [01:02:00]