[00:00:00] Carl Lanore: [00:00:00] welcome back to another episode of super Yuma radio. Today is August 31st, the last day of August in the year 2020. And we have a very powerful show for you today. Um, but before we get started with that, I have to thank my title sponsor, a company that has a great role in making this show possible. And that's legendary foods.

[00:00:23] If you go to the website, eat legendary.com and use the code, the coupon code. S H R 10, you'll save 10% off your entire order. And if you're a high protein, low carb keto type person, you're going to love the products that they make there that allow you to feel like you're cheating on your diet, but you're not.

[00:00:44] So check them out. Uh, they are a wonderful company and of course, feel free if you're watching live to post questions. And we'll try to work your questions into the discussion today, uh, as we can. So please do that. Uh, today I'm being joined [00:01:00] by dr. McKell black scrawny that I'm honored. I think this is the only podcast you do.

[00:01:05] Am I correct about that?

[00:01:09] Dr. Mikhail Blagosklonny, MD PhD: [00:01:09] Uh, we'll do that one again. And

[00:01:12] Carl Lanore: [00:01:12] do you, who, what are the podcast shows do you do besides mine? Uh,

[00:01:19] Dr. Mikhail Blagosklonny, MD PhD: [00:01:19] it was another cost maybe three months ago by mom and gun. Okay. Yeah.

[00:01:27] Carl Lanore: [00:01:27] Okay. I'm very proud that you come on this show because you understand that this audience is intelligent and they can gather information and make critical decisions on their own.

[00:01:38] So I'm very proud that you come on the show. Can I get you? Wouldn't be the timing of today's interview. Was actually in the works weeks ago, but we couldn't have planned it better because just this week, the CDC announced that only 6% of all COVID-19 deaths were actually because of the [00:02:00] virus and 94% will be because of co-morbidity.

[00:02:06] And this. Message from the CDC fits nicely into the discussion today. But before we get into the discussion, as a couple of things I have to do to pay homage to you, um, I had never heard of senescent cells before you. I had never heard of the use of a cancer drug and a anti rejection drug called rap myosin.

[00:02:32] Before you started talking about it today. Everybody out there is the rapid myosin expert. Everybody out there is the one that sees themselves as the thought leader. Tell, tell my audience the story that you told me off the air a minute ago, when you published your first paper and it was rejected. Don't tell the audience that story.

[00:02:51] How long ago was that?

[00:02:53] Dr. Mikhail Blagosklonny, MD PhD: [00:02:53] Uh, so it's like 15 years ago. Um, I was [00:03:00] working on a, so sell a cell senescence and we've found that, uh, senescence is a critic, continuous growth. It doesn't require any images. You just want sales stop. Uh, you're widen, but continue to be stimulated to grow and it cannot grow in size and definitely, uh, it's become center sent instead of, so send us on suppose like, um, abnormal growth.

[00:03:40] And because growth is driven, bye  my son and about my son oppressed these protests. So, so, but then, um, it turned out that this is applicable to organism age, [00:04:00] and not only to send us civil, as famous people said,  grow. Also, um, continuously has the age and the age related diseases. The same doctor for my son was supposed to for the look or the gun user agent.

[00:04:20] So yeah, the beginning, I thought that it will make us see more cool. So my first paper was called teaching unto mortality. So it did time. It was. Korea for us in our lab that buy some book sales centers, but it was not knowing that it will extend lifespan like . So, um, I was trying to get grants for them.

[00:04:52] It was impossible. I was rejected everywhere and, um, Well, I know where you put [00:05:00] it was rejected the night. Uh, I might the predictions inclusion that my son will extend like in mice and so on and so on. And my last prediction was that five years from now. Uh, Peanut idea will become mainstream and it will be one we'll use it without say thief and or my word.

[00:05:29] So basically it's not completely correct prediction because the world, some people cite my work. Yeah. Yes. Hadn't second. It's an open plate and not tough to fight, but they would say after 10 years, 10 years, yeah. Yes. So yeah, doing two or  my son extend [00:06:00] lifespan in mice. We will support people next year in between Tim and then it was like three.

[00:06:12] It does. Well, probably an extent couldn't like split on mine. Julian, all diseases increase in calls, not coming in mice because all animals wow. In a cold war that are go fuel.

[00:06:37] Yeah. Like most year, last year it was my son extend slaves play in heat. It's a, I even don't know how to play. Yes, it's what's supposed to be

[00:07:01] [00:07:00] Carl Lanore: [00:07:01] Okay.

[00:07:03] Dr. Mikhail Blagosklonny, MD PhD: [00:07:03] Yeah. Uh, H Y E R a. So yes, it was to become a union. So, so just

[00:07:30] And it was approved clinical use in 1999. So it's by millions of  John's mostly transplant patients and then it was used

[00:07:53] Okay. Knows these ducks.

[00:07:56] Carl Lanore: [00:07:56] Well, yeah, they're very, they're very, they're very safe when used [00:08:00] appropriately. Uh, there, there are some people out there who, you know, always take everything too far. There are, you know, I know that there was some studies out in California where they were giving dogs, myosin daily at high doses, and the dogs didn't do well.

[00:08:17] Um, so the, the, uh, there are some people that I've met. They all, well, the science behind that is dangerous. No, it's not dangerous. The protocols that are being used and suggested for people are very low, much lower than the tolerable doses, given to people as a kidney, anti rejection drugs. So it, you know, it's, it's, it's, it's, it's deemed a safe drug to use.

[00:08:44] Dr. Mikhail Blagosklonny, MD PhD: [00:08:44] Yeah, but I know old publications, but they don't know any publications that report. My son is dangerous. Right.

[00:08:55] Carl Lanore: [00:08:55] There's no LD 50 on rapamycin, right? There's no LD. Okay.

[00:09:00] [00:09:00] Dr. Mikhail Blagosklonny, MD PhD: [00:09:00] Yeah. Interesting description. Um, plea, suicide attempts, uh, for example, one young. Fun. It took more than 100 tablets for my son and no symptoms up to them.

[00:09:20] So yes, the only symptom was, yeah, the PG Mia increase in blood. It's uh, It's the last, like placebo two weeks up to that, but that's it? Uh, yes, but, um, it's difficult to talk about saying the flex or for my son, because, uh, it will take several days talk about,

[00:09:53] Carl Lanore: [00:09:53] right. So let's do this. Let's let's jump into your paper.

[00:09:58] So you

[00:09:58] Dr. Mikhail Blagosklonny, MD PhD: [00:09:58] might just want [00:10:00] to say that almost everything is Legion. For example, it was publicly, uh, 15 years ago, a suitcase, you know, rapamycin use with diabetes in transplant, patients really weak, but it was so. One publicly, but then other researchers analyzed this paper and they felt that it's incorrect because it was curly.

[00:10:29] And between, um,  billion Queens, Julian with your sock rapamycin. And this could you leave? They plant that they also take . Yeah. And my son increased their concentrate. And so it was completely out of the rack, but people continue to say this paper. So yeah. What I like to say [00:11:00] now that I'm. About my son, you save, but then ice cream ice leads to type two diabetes.

[00:11:15] No.

[00:11:17] Carl Lanore: [00:11:17] So let's talk about your most recent paper and the paper is called from cause of aging. You know, let me put it up here. Oh, it's up there from cause of aging to death from COVID-19. Why did you feel compelled to write this paper? First of all, I want to bring one, one topic up. As we walk into this, we know that during, uh, the outbreak of this pandemic, there was one phenomenon that was spoken about that many people.

[00:11:47] It went right over their head, but on the diamond princess, there was a couple, the husband had had kidney transplant. And he was taking daily doses of [00:12:00] rap myosin. The wife did not have rapid myosin. They both contracted COVID-19, but his symptoms went away in a day and she was hospitalized and couldn't leave the boat for a month.

[00:12:17] He went home without her because they said to him, you're fine. You, you can't be here, but we have to keep her here. And. Everybody missed it. When the news said he's a kidney transplant patient, I looked at Alyssa and I said, he's gotta be on serum Lemisol or rap myosin. I said, that's what they give you the kidney transplant.

[00:12:35] But for anti rejection, that's why he didn't get severely sick from COVID-19. Do you remember that?

[00:12:42] Dr. Mikhail Blagosklonny, MD PhD: [00:12:42] Yes, of course. To make any conclusion on one case. Yes, but, but it tasted feeds.

[00:12:54] Carl Lanore: [00:12:54] Yeah. Yeah. So go talk about your paper, this paper. So

[00:13:00] [00:13:00] Dr. Mikhail Blagosklonny, MD PhD: [00:13:00] even

[00:13:03] back in March, uh, main 80 searches and mainly, uh, readers noticed something, uh, simultaneous. Yeah. They not just that, um, Death from mortality rate from COVID-19 was age dependent,

[00:13:28] Carl Lanore: [00:13:28] right? Stratified by age. Right? Exactly. The older you were, the more likely you were to die, right?

[00:13:35] Dr. Mikhail Blagosklonny, MD PhD: [00:13:35] Yeah. So this is a clear, uh, that.

[00:13:43] Natural for, uh, from my age, but, uh, dots show there from  and they go together except childhood because he childhood COVID is not dead yet, but [00:14:00] Nicola is Skype in inference. Right. But it's a ghost the same. Right. So it was perfect. Could you leave an exponent fell and it was stallion. So when you people approached me and they said, I might degrade discovered it, I just discovered it too, that we could use and teach and drugs, then it could help.

[00:14:30] And I also just kind of that, but, but, but let's just cover that by. I think fell ovens because it was easier. So I just to write in the paper, but then the realized just that, uh, other people are already doing it, doing this public forum. And I decided that instead just talk or something like [00:15:00] that to go to mayor can use them to explain why agent make a difference.

[00:15:07] Well, I'm a rebel. So, um,

[00:15:13] basically a virus

[00:15:24] agent is Mississippi too. So it was another calculate from, um, that 99% off. Uh, but on school day, could they hit H two diseases? Yes. It's hypertension, diabetes, cardiovascular disease. I'd be sitting here, uh, alum and so on.

[00:15:58] It was like, [00:16:00] uh, Mortality depends on age, but at the same time, it's dependence on diseases, but they just no contract. You can have this because agent is when you place it by diseases. Aging is the sum of all age related diseases. No one dies from age in itself,

[00:16:21] Carl Lanore: [00:16:21] right? Yeah. You don't, you don't die because of the number you don't die because you have the number you die because the older you get, the more diseases you.

[00:16:30] Dr. Mikhail Blagosklonny, MD PhD: [00:16:30] Accumulate, right, right. Yes. But if you're cumulate, please diseases means that your biological each is low. Uh, and if more higher. So this is why a mortality rate from COVID-19 deployments on biological age, not, not on a chronological. So. Age [00:17:00] related diseases. So markers and also some COVID-19 was twice more  than women, but the, see them natural dip be able a year, twice more in my way or no.

[00:17:22] For today, each class. So people get that. So basically COVID-19 vulnerability champ.

[00:17:32] Carl Lanore: [00:17:32] Yeah. Yeah. There you go. You're right in the center. Perfect. Diabetes, COPD, P D dementia, obesity.

[00:17:38] Dr. Mikhail Blagosklonny, MD PhD: [00:17:38] It's each related Kanji. So it could like other diseases. So of course all of them could relate. Once again, vulnerability is.

[00:17:50] When your some get impacted gets infected, that this person will die [00:18:00] because in that village, it doesn't depend from age, but outcome survival.

[00:18:06] Carl Lanore: [00:18:06] Survival depends. Yeah.

[00:18:08] Dr. Mikhail Blagosklonny, MD PhD: [00:18:08] Yes. So it's typical each elated disease, so you can help be. COVID-19 vulnerable in the absence of virus, but when you get by then it will be little so, and it could be explained by, um,

[00:18:37] each of the lead to diseases.

[00:18:40] Carl Lanore: [00:18:40] But, but, but in, in its simplest terms, we could say. Comorbidities is another way of saying the accumulation of age related diseases in its simplest way. Right? We can say so when they talk about comorbidity, because let's speak honestly here, who dies from the flu old [00:19:00] people, why do old people die from the flu?

[00:19:03] Because they already have heart disease, diabetes, asthma, um, all these other problems that make it difficult for their body to Mount. A fight to survive a severe illness.

[00:19:20] Dr. Mikhail Blagosklonny, MD PhD: [00:19:20] Yes. This is one way to look at this one. It's not, they're not mutually exclusive that these diseases are markers or markers or some other processes, for example, um,

[00:19:37] Carl Lanore: [00:19:37] that cytokines I see. Okay.

[00:19:41] Dr. Mikhail Blagosklonny, MD PhD: [00:19:41] Bye. Bye. Yeah, totally. Um, storm hyper the fund for no, uh, where it is thrown in native mode, serious point that really kills the play, not virus itself, [00:20:00] but, uh, uh, the venues Mo is sports.

[00:20:04] So it's not that immunity is weak.  too strong,

[00:20:10] Carl Lanore: [00:20:10] right? Overreacts it sets, it sets the whole body on fire,

[00:20:15] Dr. Mikhail Blagosklonny, MD PhD: [00:20:15] right? Yes.

[00:20:16] Carl Lanore: [00:20:16] Yes.

[00:20:17] Dr. Mikhail Blagosklonny, MD PhD: [00:20:17] And by the way, this is why the children, children, they care infants, they care so-called, Wikimania chair vulnerable to influence for example. But in contrast, they don't die from COVID because, um, They don't, they don't give this hyper.

[00:20:42] It is poems so they can store.

[00:20:46] Carl Lanore: [00:20:46] So what do you think it is about senescent cells that seem to lead to this hyper responsiveness of. Is it, is it the senescent cell itself that's causing the hyper [00:21:00] responsiveness. And so the more you have the greater the response or are they triggering something in the immune system that is causing this hyper response?

[00:21:13] Dr. Mikhail Blagosklonny, MD PhD: [00:21:13] Mmm.

[00:21:18] In cell culture. Um, so cell set hyperfunctional for example, a hyper secretory phenotype in this production of say the cans and so on, depending on function of the cell, uh, but in their Kenya, some, uh, Only if your sales classically CMS, but it doesn't mean that those that don't look seen as something they are not, they are, they feel okay of not more smart  [00:22:00] but the, the activity slightly at a higher than necessary.

[00:22:05] Yeah. If they are hyperfunctional any way inclusion in the immune system storm in immune system, some bottles like  just points to strongly other parts in contrast, don't respond too strongly because it's really a complex system. Elements that are hyperactive radioactive. They can look, are they linens? So, um, what rapamycin can do, please even function in immune system.

[00:22:51] Some of some elements like production of antibodies, but to me, France, because it's [00:23:00] inhibits, uh, Stamps at sales or sales that in Germany know, keep it, um, uh, probably not production of pointy by just too close to home. For example, in humans that look tonight, um, with that rapamycin improve vaccinate from, uh, against flu virus.

[00:23:30] Yeah, entry crease. Yes. And decrease, um, uh, non both cases of employee on site floor.

[00:23:44] Carl Lanore: [00:23:44] That means we could think of rapamycin as an adaptogens. It lowers what needs to be lowered and it raises what needs to be raised.

[00:23:54] Dr. Mikhail Blagosklonny, MD PhD: [00:23:54] Yeah, it's

[00:23:59] I will not [00:24:00] feel good.  it's a, uh, innate immunity make him like, uh, In the pump, like in your chair. So, uh, it would make sense because it, and, uh, but of course it's always simply SIM

[00:24:20] Carl Lanore: [00:24:20] now. Yeah.

[00:24:22] Dr. Mikhail Blagosklonny, MD PhD: [00:24:22] Yeah. Uh, so what about my son can feel effect, um, on you put on steps or purchase points, if you just, um, In peanut here, if your son takes it for my knee, uh, biological, each is lower.

[00:24:48] So, uh, the person is young, you know, simple words. So we'll deal with coronavirus. [00:25:00] But of course we don't know about it because it takes awhile. That clinical trials that were started? Uh, yes, uh, the rest of them. Um, you can use them or put up on my son, for example, one clinical trial in CV, uh, orbit 19, uh, Pneumonia.

[00:25:32] So in order to prevent site, they can store, right? So we will cover itself of this clinical trial, where they top here for, for, uh, other was, um, given, uh,

[00:25:57] Good for you from [00:26:00] possible. Um, it will require huge clinical trail, of course, in order to improve for your new chair.

[00:26:11] Carl Lanore: [00:26:11] So you're saying as a pro, as a prophylactics, a prophylaxis to take it before you actually get sick.

[00:26:18] Dr. Mikhail Blagosklonny, MD PhD: [00:26:18] Right. So there are several clinical trials. This is all important because when can March, uh, my new doctors who could be prescribed by my son to their patients that didn't know what to do to continue, please keep phenol or to stop.

[00:26:40] Carl Lanore: [00:26:40] Right. Because they, they, they will, they don't want to kill the person if they get COVID-19 and they're taking rapamycin, right. Right. Right.

[00:26:48] Dr. Mikhail Blagosklonny, MD PhD: [00:26:48] And, um, it was safe for her to stop and to basically when your doctor stopped, but I know [00:27:00] that they continue to take her for my son themselves. Some fans. Well, you can put your still

[00:27:08] Carl Lanore: [00:27:08] yes.

[00:27:09] Not your patient,

[00:27:10] Dr. Mikhail Blagosklonny, MD PhD: [00:27:10] but yeah. But, but as I understand. Then this fear or put up on my son went away. Like now I'm not. Like before COVID-19, but mighty beta, it probably COVID-19 promoted your soccer. My son is perfectly given these clinical trials that started at least the thought that it's not dangerous. We don't know yet.

[00:27:45] Is it useful, but not dangerous. So this is why I. The title of my talk at a per my center post COVID-19 era, [00:28:00] because  the spongy mic, uh, attracted more into the story, my son, and, uh, put more to it. It's yours. I am receiving the mails from many doctors or applying and to start treating patients, it's unrelated to code with names and because, well, Jamie Cuco and, uh, Might be  um, ways to clear what is going right now.

[00:28:39] It's a still fewest wave. It was just, uh, right. Yeah. It's not second way. Probably it will be no second way, because since such place like New York where I'm. [00:29:00] Uh, probably everyone who could be infected

[00:29:04] Carl Lanore: [00:29:04] has been infected.

[00:29:08] Dr. Mikhail Blagosklonny, MD PhD: [00:29:08] It's certainly related to my talk, but I believe that not everyone can be infected so much less number of people.

[00:29:18] Carl Lanore: [00:29:18] We actually, we actually did a show a couple of weeks ago where a scientist from Israel showed that. Uh, the people with the highest 25 hydroxy D levels seem to have protection against even getting infected in the first place. So I thought that was fascinating. So there's a lot, as you point out, there's some people out there who just they'll come in contact with it and they won't get infected, but we see that across the board on lots of disease States, uh, in science, we see, um, outliers.

[00:29:53] Who, for some reason they could be exposed. Those are the things and they just don't, they don't catch it. So it makes sense that they [00:30:00] would, that would be the case with, with COVID-19. Also, I have to take a break. I have to take a break. I'm going to ask you to hold your thought. Just for a second. I want to take a break.

[00:30:09] When we come back, I want to start talking more about rap myosin in a post COVID environment, because I really think that what a lot, one of your work is pointing to today. Is that it's not, it's not just COVID-19 that we will be protected against mortality when we address senescent cells. You know, my biggest frustration is when I first started doing this show 14 years ago, a lot of people thought when we talk about anti-aging.

[00:30:43] We're talking about living forever. We're talking about dating younger women. We're talking about looking, looking like a 20 year old again, and I've always been talking about the. Suppression of age related diseases. And I really [00:31:00] think that what your work points to is a much grander picture than just COVID-19.

[00:31:07] It's all older people die from everything easier. Why? Because the accumulation senescent cells taxes their systems and such a great degree that they are not capable of mounting a response, a healthy response to anything. And it kills them. So I really think that I want to come back and talk about the fact that I think that what your work is really providing us with is a blueprint going forward to change the way allopathic, medicine treats people only when they're sick and starts treating them before they get sick entirely.

[00:31:41] Okay. Can we talk about that? When we come back?

[00:31:43] Dr. Mikhail Blagosklonny, MD PhD: [00:31:43] Yes.

[00:31:44] Carl Lanore: [00:31:44] Okay. I stay tuned. We'll be right back with more of dr. Miquel blackest cloning. You were listening to the superhuman channel. Don't hate us because we feel good.

[00:31:57] Welcome back. We're talking with dr. McKell [00:32:00] bloggers is cloning. We were talking about Rappa. Maya said we're going to change the discussion slightly. We were going to talk more about this study, but I want to open the discussion up because really, I think from the 30,000 foot view, When we look at how rapid a myosin can provide help, prevent, help protect against dying from SARS Cove too.

[00:32:25] We, we, we can't ignore the fact that the reason people are dying from Sardis Cove too, is because of the accumulation. Of diseases associated with aging and those disease States can be tracked right back to the hyper accumulation of senescent cells. The more you have the sicker you are. So why aren't we talking about this research as evidence that the way forward to treat patients should include a specific systematic.

[00:32:56] Um, uh, what's the word I'm looking for? [00:33:00] Intermittent, uh, addition of rapid myosin to everybody to reduce the, the, the buildup senescent cells so that I don't die from my D I don't die from my, my heart problem because the body actually can mountain attack and repair these things.

[00:33:22] Dr. Mikhail Blagosklonny, MD PhD: [00:33:22] Yes.

[00:33:26] When I just started working on that 15 years ago more, um, our idea was that we can delay all age related diseases by treating each

[00:33:44] by a foot to Egypt. And, um, yeah, target took her by my son was involved in. All, no one really to diseases, [00:34:00] inclusion, uh, counts, uh, zero is just at sky GCs, obesity and so on. So, and all of them can be delayed by one treatment because it's a quick. Not specific disease, but they're common cause aging. So you have

[00:34:26] Carl Lanore: [00:34:26] these,

[00:34:27] Dr. Mikhail Blagosklonny, MD PhD: [00:34:27] that is rapamycin.

[00:34:30] Um, personally, because on coaches, I am most fascinated with them. It's a

[00:34:41] And what does interest in. There was water in cancer research, uh, completely unrelated to aging research to geoscience on [00:35:00] pretty well can or can't Sam. Bye. What about my son? You know, my, uh, my privilege work was published in . It was 90% reduction of lung cancer in mice, mice that were given to, to smoke.

[00:35:24] Yes. Yeah. The authors actually suggested that maybe it. Well, small percent former smokers take her up on my son. Uh, I don't know why

[00:35:42] was not, um, then senior much, uh, what is also interesting that, um, when would read my. We're there by my SIM to extend plates plan a [00:36:00] simultaneous sort of by my son Julie's cancer.

[00:36:06] Carl Lanore: [00:36:06] Okay. It's

[00:36:07] Dr. Mikhail Blagosklonny, MD PhD: [00:36:07] perfectly, it's all in cancer prone, mice. So, um, this, this is where the logical count sees each related disease. So, um, It's one of GCs is delayed by rapamycin, but my son, I called one of my papers.

[00:36:32] Um, but he, you know, have cancer by steam. Yeah. So yes, am, uh, what empty in them? Great contrast to this, um, clinical trails with antioxidants. We were terminated 20 years ago. It was many clinical trials that [00:37:00] antioxidants, um, would be lung cancer in smokers, but instead the increased

[00:37:09] Carl Lanore: [00:37:09] yeah, of course, reactive oxygen species actually suppresses.

[00:37:14] Tumor cells from growing. And so if you suppress ROS continuously, you you're creating fertilizer for the, for the, for the cancer cells. Okay. So I want you to connect some dots for me. I just had a thought, um, dr. Thomas C fried, who authored the book, uh, cancer as a metabolic disease or disorder, uh, did several really well done studies showing.

[00:37:43] Pretty clearly that it's, it's the mitochondria that switches to anaerobic respiration before uncle gene start flipping on and doing and turning cells into tumors. And so my question to you is what is the [00:38:00] relationship between am tour rapid myosin and possibly my top muggy. Well mitochondrial function.

[00:38:11] Dr. Mikhail Blagosklonny, MD PhD: [00:38:11] Yes. So, um, my son stimulates my topic. Uh,

[00:38:20] Carl Lanore: [00:38:20] so

[00:38:23] Dr. Mikhail Blagosklonny, MD PhD: [00:38:23] Andrea, they put two can be all tough wage then replaced by, but, uh, um, and, um, Okay, but I just want to say that, um, rapamycin, although it was approved to treat cancer, to go with it, it's on Alex and Alex, like a most, they are not extremely important. Anticancer drugs.

[00:38:59] God, [00:39:00] this, uh, Korea was predictable. They affect aging and that's delete counts.

[00:39:07] Carl Lanore: [00:39:07] Yeah. Indirectly affect cancer. They indirectly affect cancer.

[00:39:12] Dr. Mikhail Blagosklonny, MD PhD: [00:39:12] Yeah. But we're consolidating them, um, arise. They cannot kill cancer cells. So they are not cytotoxic. This is the beauty of these straps. This is why they are not toxic to few months.

[00:39:30] They don't kill cells. So I'll go home a B teeth cancer, but it's not they're yours. We can securable right. This is what I want. Yeah. So it's mostly prevalent from, by the way, this prevention was observed in renal transplant patients. Right? Because [00:40:00] they feel a lot of scheme comes this really predicatively stick, but when, uh, they were switched on , uh, Incidents of skin cancer that are multicolored decreased.

[00:40:20] So, uh, it's absorbed by chance and suppose many public with it. Uh, but the same with them all other age related diseases and, um, Now there's great enthusiasm in to yours. My son for Alzheimer's disease and Parkinson's disease. It was a term to use four. Okay. Um,

[00:40:55] but local, uh, interestingly. Yeah.

[00:41:03] [00:41:00] You're now focused mated group assists in skin color. And some doctors prescribe a put my skin cream. It's not cannot fill available yet, but it could be done.

[00:41:23] Carl Lanore: [00:41:23] What's a, but some of that is being delivered systemically because we know anything that gets in to test the stratum corneum gets picked up by blood vessels and delivered systemically as well.

[00:41:32] Right?

[00:41:34] Dr. Mikhail Blagosklonny, MD PhD: [00:41:34] Yeah. So

[00:41:40] is increasing, um,

[00:41:42] Carl Lanore: [00:41:42] like

[00:41:43] Dr. Mikhail Blagosklonny, MD PhD: [00:41:43] report it

[00:41:48] so it's. It's not like on

[00:41:57] it's to prolong life so we could [00:42:00] help  diseases and typical stocks of this broken approximately six years ago, dr. Holland green put all my work. Yeah, he creates now more

[00:42:19] Carl Lanore: [00:42:19] patients. I know, I know one of his patients and I hoping he's listening today. I'm not going to mess. You mentioned his name. Cause I don't want to, I don't want to be caught in a HIPAA lawsuit, but I know one of his patients and he is doing amazingly.

[00:42:33] Uh, he's around my age and he's in fantastic shape. He feels better than he's ever felt before. He's feistier than he's ever been before. He's from Brooklyn like me. So he's a real chop breaker, but, um, I know, I know one of his patients and have very, very happy and, and I, I wanna, I want to do something.

[00:42:51] There's a question that I want to get answered for someone in the audience. But then I want to talk about, we have to take one more break. When we come back, I want to talk about the [00:43:00] fact that you want to start opening clinics around the country so that you can bring this science, uh, usable science to other people in the United States.

[00:43:10] So let's just do this, let's answer this question first. Samurai Jack is watching on YouTube. He says, ask dr.  if he's heard of the dog aging project, uh, giving dogs rapid myosin to extend life. I kind of inferred to that a second ago, but have you heard of them?

[00:43:29] Dr. Mikhail Blagosklonny, MD PhD: [00:43:29] Yes, my  is the Iranian study for money.

[00:43:38] I'm not involved in any way and unfortunately, It was almost not in public. He had told me that. Um, is that okay? A lot of stories, but, um, it's not a gift. Yes.

[00:43:55] Carl Lanore: [00:43:55] I've I've heard that that's where they were having problems with the unwanted [00:44:00] effects because they were giving the dogs daily doses very, very high daily.

[00:44:05] So, so let me, let me tell you why. Let me tell you why I have not been a more diligent fan of rapid myosin. I just take six milligrams every other week, twice a month. And the reason I don't take it more frequently. Is because I'm afraid that I want that I'm going to suppress mTOR too much because I want to keep my muscle.

[00:44:30] I want to stay strong. I want to stay muscular. So tell me why that I'm incorrect about that.

[00:44:37] Dr. Mikhail Blagosklonny, MD PhD: [00:44:37] Yes. Uh, first of all, it's true. Like we snow too much or for good stuff. It is in mice. They're higher doors. The longer life span. It was never maximum spin was never reached. It was never study that increase. Or [00:45:00] my son go there.

[00:45:01] Do you, could you explain, explain it's the oldest goes up second about, um, muscles, uh, that are when you start just the, my son threes. But he will sell clipping you

[00:45:18] Carl Lanore: [00:45:18] really?

[00:45:19] Dr. Mikhail Blagosklonny, MD PhD: [00:45:19] Yes. I put information on my website.  dot com. I didn't publish this review, but yes. And, uh, I am taking it upon my son. Uh, I, I put ETO on a Twitter, how I do this and.

[00:45:43] I exercise now a lot. I, I can do pull ups increasingly. Now I can do four or five pull-ups just five years ago. I could do stealer.

[00:46:01] [00:46:00] Carl Lanore: [00:46:01] So I, and so here's the, here's the second part of that question. I actually texted this to you a long time ago, but it fits nicely into this discussion. So. Rapid myosin, suppresses mTOR consuming, large amounts of high quality animal protein high in leucine turns M Tor on.

[00:46:24] Now we've talked about it on this show for years. A wave of mTOR and autophagy is what gets the most muscle built. If M is turned on all the time. Then by the muscle synthesis, protein synthesis is shut down. If mTOR is always off, protein synthesis is on. So we know that the body likes phases, M Tor autophagy, M Tor autophagy.

[00:46:49] So my question to you is this. If I take a large dose of rap myosin, Let's say I take 20 milligrams in one day. That [00:47:00] should last, I think they have five, three days. Theoretically, if I ate 400 grams, high leucine protein a day, would that blunt the effect of rapamycin? Would it contribute to MTR turning on for a little while?

[00:47:16] Has it, yeah. Anyone looked at the effects of rapid. Yes. And in the face of high protein intake.

[00:47:26] Dr. Mikhail Blagosklonny, MD PhD: [00:47:26] Yeah, there's some missing. And part of my friend here, it's important that my son doesn't inhibit all activities. So from, for

[00:47:42] and many other rapamycin, if they continues. So, um, Yeah. I mean, they activate all activities, so different activities. [00:48:00] So it's not that they're completely onto the game. Okay.

[00:48:06] Carl Lanore: [00:48:06] Okay.

[00:48:08] Dr. Mikhail Blagosklonny, MD PhD: [00:48:08] So I do have a lap in until 20 strictly, but so for my son, Does some decreased muscle size. It's now proven in when you started it, doesn't decrease.

[00:48:22] Uh, why does it decrease it? So now, if you're of course doing this particular.

[00:48:29] Carl Lanore: [00:48:29] So we're going to take our last commercial break. And when we come back, we're going to talk about the fact that you are endeavoring to open clinics throughout the United States. And I want to allow people from this audience to be able to reach out to you, uh, and talk about what the future looks like for the, what I consider the next phase of optimistic medicine.

[00:48:50] Optimistic medicine. We're going to talk about that. When we come back, stay tuned. We'll be right back. Spit that out right now. This is the superhuman channel.

[00:49:03] [00:49:00] we're very fortunate to have dr. McKell black, a Sloan here today with us. He is a thought leader in the area of longevity and, um, it's, uh, it's it's it's. No accident that much of his early work is now being followed by physicians and scientists to the same end point that he discovered 15 plus years ago.

[00:49:29] And that is that by. Modifying the landscape of M tour and reducing the accumulation of senescent cells. People can. And you know what? This, this may not really extend your life per se. And I want to qualify that when I say that I want to, I don't want people to get mad at me, but if you are, you're starting to see the ALIS static load of accumulation of diseases and you're slowing down and you can't do the things you can do.

[00:49:55] You can't sleep well. You're going to die sooner than you need [00:50:00] to. Um, by eradicating those diseases, you will end up living longer than had you had those diseases. What I want to be careful about when we talk about anti-aging is getting painted with the zealot paintbrush that we're going to. There are people out there talking about living to be, Oh, 280 years, uh, is possible.

[00:50:22] You know, nobody knows that for sure. I mean, that's his guesswork, I mean, you know, we're like flash Gordon. Yeah. We can live to be a thousand. If we could replace all of our parts and we'll have nanobots by immuno that's that's Saifai stuff. But. Eliminating disease States. Now the accumulation of these disease States, the life energy that they Rob from you day in and day out will absolutely make you live longer than if you keep them in place.

[00:50:48] And so that's really what we're talking about here. We're talking about not just lifespan. But perhaps even more importantly health span, because I don't want to spend the last 30 years of my life in a [00:51:00] diaper, in an institution waiting for someone to roll me into the kitchen to get something to eat. So I just wanted to kind of preface it.

[00:51:08] So you have been. Wanting for at least the past seven or eight years, you started talking to me about it. You've been wanting to start opening clinics throughout the United States to bring this science to the masses, correct?

[00:51:25] Dr. Mikhail Blagosklonny, MD PhD: [00:51:25] Yes. Because a lot of potential payphones could not find, but then feel that it was fun.

[00:51:33] One clinic. By dr. Alan Green for money. Yes. And she said that even placements from New Zealand, Australia will comment here. So, uh, it was mainly people who wanted to live long game help here, but, uh, it was not. [00:52:00] Such clinics and doctors, but now Stephan changed the change Mexico Julian one year. And, uh, I am not going to  they foot tight open clinic anymore because they are opening up the sales.

[00:52:21] Yes. Yeah. For example, a great clinic by dr. Randy Smith in 90 each, in Atlanta. Yeah. He will, um, pretty nickel trails open up on my son. So, um,

[00:52:45] Pretty well into age related diseases. I know H R X a clinic in Chicago. Yeah. All, they will appear it online. So it will make everything much [00:53:00] more easier in all States. Uh, something like that could put your name in Europe too, so

[00:53:10] Carl Lanore: [00:53:10] well, and I want, I want to, I want it so. About a year and a half ago, I started saying to you, this is do this online because why dot the landscape with clinics?

[00:53:19] I think that one of the beautiful things that happened from COVID-19 was. The general acceptance of telemedicine, it became, it was overnight. It went from telemedicine is dangerous. And doctors who were performing telemedicine will look that is possible, uh, crossing boundaries that they shouldn't to, uh, Fowchee buddy up there going no, you know, telemedicine, you don't, you can't go see your doctor.

[00:53:43] So by Skype, I see him by zoom. So the general acceptance of telemedicine has actually opened up door for something that I've hoped for, for a long time. Like, like dr. Green. Is he accepting telemedicine patients yet? I

[00:54:00] [00:54:00] Dr. Mikhail Blagosklonny, MD PhD: [00:54:00] don't know.

[00:54:00] Carl Lanore: [00:54:00] I'm going to email him later and ask him, I wouldn't email,

[00:54:04] Dr. Mikhail Blagosklonny, MD PhD: [00:54:04] not in touch with Hema, but, but other doctors, they accept

[00:54:11] This is,

[00:54:12] Carl Lanore: [00:54:12] this is so exciting because if you're listening to this show or you're watching the show right now, that means that, where do you want people to first of all, where there's a lot of physicians that listen to my show. So first of all, if there's a physician out there who wants to be trained so that he or she can offer this as a therapy, where do they go

[00:54:35] to your website?

[00:54:38] Dr. Mikhail Blagosklonny, MD PhD: [00:54:38] I don't. Well, I would be happy if they will email me, uh,

[00:54:48] dot com. 

[00:54:51] Carl Lanore: [00:54:51] at Rappa logs.com.

[00:54:54] Dr. Mikhail Blagosklonny, MD PhD: [00:54:54] Okay. For example, I will put it on the website, but, um, [00:55:00] I am interested too. Kelp financial. Yeah. Maybe donate some money. Well, this I am not working for profit. I don't sell anything. I don't make money on this. I don't keep this in contrast. I am starting to spend my mind. Yeah, I will.

[00:55:24] I'm open. You're now a supplement foundation.

[00:55:29] that will donate money for the florist, not for the first time for clinical trial, for my son, the clinics. So, uh, and I don't know why I want to do this.

[00:55:48] Carl Lanore: [00:55:48] I know you said that to me. You said I don't need to be doing this stuff anymore. Carl you're like, and I said, well, you know, I feel like it's important because.

[00:55:55] You're you're the OJI in this space of medicine. And I feel like [00:56:00] it's important that you stay involved, but I know you're very happy, uh, living your life now, you don't really need this anymore,

[00:56:08] Dr. Mikhail Blagosklonny, MD PhD: [00:56:08] right? Because I have all these teach interacts. I mean, couldn't be named not by my son. So if you're Somalia, I am fine.

[00:56:21] But, um, But I won't look out for like sense of new fund, some pursuit of immortality, something big. So, um, yeah, so my phone different will help. Um, yeah.

[00:56:48] Yup. Everything is changed him. Julian. The last year it's become accepted just one year ago. It was only to dr. Alan Green.

[00:57:00] [00:57:00] Carl Lanore: [00:57:00] I know it's amazing. Um, after I let you go here shortly as the interview comes to an end, I'm actually going to come back and talk about my theory on why men are affected by COVID more.

[00:57:16] And why men die younger. And it's a very simple thought I'm going to, I'm going to give it to you now. And then I'm going to go on the other side. And I don't, I don't want you to be tied to my theory because people say, Hey, that guy's a quack, but I have this feeling that, uh, iron accumulation. Increases the, uh, ability for cells to become senescent and testosterone increases iron absorption.

[00:57:41] That's a very ultra simplistic statement, but that's, my mind is not as sophisticated as yours. Mine is quite simple. What do you think about that statement?

[00:57:55] Dr. Mikhail Blagosklonny, MD PhD: [00:57:55] Uh, I think that it might make [00:58:00] sense. But, uh, I just, Nope, first of all, I couldn't no everything in detail, right?

[00:58:11] Carl Lanore: [00:58:11] Yes. Okay.

[00:58:13] Dr. Mikhail Blagosklonny, MD PhD: [00:58:13] But, but about Ireland, it makes sense. And, but. You can take a view on something from very different perspective. You can take your from IRM, you can take your from something else. Yeah.

[00:58:33] It will be not complete picture. I am taking a view from Tor, right. For simple. It is then because we cover

[00:58:42] Carl Lanore: [00:58:42] the dark. Right. And you ha and you can affect that, right? Right.

[00:58:47] Dr. Mikhail Blagosklonny, MD PhD: [00:58:47] Yes. Because if it will be a sum in this network and be connected and be connected with the Island, everything is connected, [00:59:00] but I chose, I call it total point of view just because these drug took tests.

[00:59:11] Carl Lanore: [00:59:11] Alright,

[00:59:12] Dr. Mikhail Blagosklonny, MD PhD: [00:59:12] so and so use clinic. Yeah.

[00:59:15] Carl Lanore: [00:59:15] So the website  dot com. M I K H a I L B L a G O S K L O N N y.com. Correct.

[00:59:25] Dr. Mikhail Blagosklonny, MD PhD: [00:59:25] Kind of now I understand that they will, uh, work on this website because it wasn't very active, but after our talk, now I must to do it, but that they cannot follow me on Twitter. Vulgar, just bogus coordinate on Twitter

[00:59:45] Carl Lanore: [00:59:45] and they can email you at  at Rappa logs are a P a L O G s.com.

[00:59:53] Dr. Mikhail Blagosklonny, MD PhD: [00:59:53] Yes, it looks.

[00:59:54] Carl Lanore: [00:59:54] Logs log. Yes. At  dot com. And I hope that doctors [01:00:00] email you and say, Hey, we want to start offering this therapy, help us. That's the first I already know I'm texting with the doctor right now, who couldn't watch live, but I know that she's gonna reach out to you. And I know another doctor is going to reach out to you too.

[01:00:15] This is a dream come true. It really is. I look, thank you so much for making time, uh, uh, to be here today, to talk about this.

[01:00:24] Dr. Mikhail Blagosklonny, MD PhD: [01:00:24] My pleasure.

[01:00:25] Carl Lanore: [01:00:25] Okay. We'll talk soon. Okay. Take care.

[01:00:26] Dr. Mikhail Blagosklonny, MD PhD: [01:00:26] Yes. Yes. Thank you.

[01:00:28] Carl Lanore: [01:00:28] All right. We're going to take one quick commercial break. And when we come back, I'm going to take my feeble attempt at, um, at science, but I'm going to try to connect some dots.

[01:00:37] I think I have some dots to connect that also include M tour in the testosterone equation. Stay tuned. We'll be right back. I suddenly realized, well, hold on. Sorry about that.

[01:01:03] [01:01:00] let me just change this.

[01:01:07] Excuse me, and get this down. Okay. So. Men die at a higher rate than women faster, sooner, earlier in life, I'm having a cough attack. Let me get some water. And they die from COVID more frequently,

[01:01:32] which means they probably accumulate more senescent cells than women, men don't age, as well as women do. I've thought a lot about this. I'm sorry. Sorry. I'm doing this to you. My nose just got stuffed

[01:01:55] having some sort of allergy attack. Anyway, what [01:02:00] we know is this men probably end up with more senescent cells than women and. Why is that? I think I know many eat a lot more red meat than women. That's a fact iron. So senescent cells have five times more iron than quiescent cells or healthy cells, but could just the eating more red meat be the answer for the development of iron in men?

[01:02:34] No. Testosterone testosterone increases the uptake of iron. We know this twice when men are on testosterone therapy, a lot of times they have to donate blood. They get too much red blood cells developing the more red blood cells you have, the more iron you have cause red blood cells need iron. But [01:03:00] the missing piece was just given to me by dr.

[01:03:02] Black is cloning. Guess what else? Testosterone levels affect M tour. Several studies show. I just found them. Yeah, I'll read this one real quick. Testosterone regulation of AKT. M tour Fox. Oh Oh three, a signaling in skeletal muscle and the Baker. The takeaway right from the beginning is men with low testosterone have low muscle.

[01:03:30] Because they have low M Tor. So that means men with high testosterone have more muscle because they have more mTOR activity. So there's the answer. The reason that I'm sorry, I'm doing this to you, doc men. Die younger than women age worse than women die from COVID-19 more than women and most likely have greater degree of senescent cells than women is testosterone and red meat.

[01:04:01] [01:04:00] I'm sorry. I love testosterone. I've been on testosterone therapy since 2007. I'm not stopping and I love red meat. So what is the answer for men? Something I've talked about on the show for a long, long time. Donate blood. I told my own son donate blood at least twice a year, starting now when you're 30, because this is where men can actually save their own lives.

[01:04:31] Donating blood is critical. So women and here's, here's the iron link. Again for women, women start to bioaccumulate iron after they go through menopause because they stop having periods. They stopped bleeding. So Ron Penna, who's also fascinated by iron. Like I am checked. He said, well, that would mean that women who take birth control at a very young age should have some sort of iron [01:05:00] accumulation and it may be mortality and disease rates related to that are in accumulation.

[01:05:07] And he did in fact, find a study that looked at women who don't take birth control. And women who take birth control pills that just make them menstruate less often. And women who take birth control methods that keep them from menstruating at all. And the death rate was in line. Those who weren't taking birth control had a much lower death rate from a variety of diseases that they looked at, those who were taking birth control pills, where they bled maybe every one, every 90 days.

[01:05:43] Slightly higher. And those who were taking birth control pills that kept them from bleeding at all, had the highest mortality rates related to certain diseases. I don't remember what they were. They were diseases that were tied back to the theory that we have about our in accumulation. [01:06:00] I can't say it enough.

[01:06:02] Donate blood. If you're a woman and you've gone through menopause, donate blood a couple times a year, you're going to offload a lot of metabolic waste when you donate blood. But more importantly, you're gonna offload iron. We bioaccumulate iron. As soon as we start eating and we have iron in us, that's probably been there since we were kids.

[01:06:27] We don't have a system to manage iron or get rid of it unless you are a long distance runner or a vegan, which will slowly start to go through the iron. So the answer to this question, why do men die younger? Why do they die more frequently from COVID-19 probably have higher level of senescent cells.

[01:06:56] Why do men have a higher level of senescent cells than women? Because [01:07:00] they eat more red meat and they have testosterone those two things right there. That's it short and sweet post the links to these studies too, that I just mentioned in today's show. If you're a physician, please reach out to dr. McKell black.

[01:07:16] His crony at  at Rappa logs are APA, L O G s.com. And get trained and I've been, I haven't used my  myosin in a couple of weeks actually. Well, almost a month. I was taking it every other week. I'm going to start taking it again because I was afraid I don't want it to cause muscle wasting, but there you go.

[01:07:38] Hi, only Monday. We have a lot of great shows this week planned. I hope you can make it. Please share the show. Help somebody we'll see you tomorrow. Thank you. [01:08:00] .