[00:00:00] Carl Lanore: [00:00:00] Hey, Hey, welcome back to another episode of super human radio. Today's January 25th, 2021. And we're going to talk about what you can do to age better in just a couple moments with Aaron Cerone. Uh, before we do that, a couple of things I want to make announcements, don't forget next Friday, or this Friday it's upon us.

[00:00:17] Casual Friday comes back on the air. Uh, it's been gone for four years. Uh, the lovely and talented Elisa Profumo will be joining me, uh, for those of you who miss casual Friday, it's coming back. So don't forget to tune in for that. Of course we have to thank our title sponsor, legendary foods, the makers of the most amazing tasty pastry.

[00:00:39] Uh, 20 grams of high quality high leucine protein, zero sugar in the new birthday cake style. It's delicious. I guarantee you'll fall in love with this. Your kids will love it. They don't have to know that it's good for them right now. If you go to SHR network.biz/legendary and use the code SHR 10, you'll save 10% off.

[00:00:58] I haven't heard that they're out of [00:01:00] stock yet, but. There are so many people on the streets buying these now because they're a great replacement for a protein bar, especially since they have a lot less fiber, a lot of people learning, wow. Fiber doesn't work well with me. This is the answer. Check it out.

[00:01:15] Of course you can win. A box of tasty pastries. Listen for the secret word, the secret word happens during the commercial breaks. Listen hard. You'll hear a word, email that word to me at, on This email address is being protected from spambots. You need JavaScript enabled to view it.. You're entered for that day. We're giving a box away a day. So your chances of winning are really, really good.

[00:01:37] If you act quickly, um, Again, listen for the secret word during the commercial breaks, and then email it to me at, on Eric Superman, radio.net, and you are entered to win a box of tasty pastries. Uh, without further delay, let's bring my guests on. We need to add someone that balances my mug and that's Aaron Cerrone.

[00:01:59] How you doing? [00:02:00] I'm great. How are you? Good, good, good, good to have you back. Um, so I want to say something, uh, I I'm not one to pander. So I want to be clear about something I wrote in too. Today's, uh, show write-up. Um, I said that, uh, this is a secret pill that we're going to talk about today, but I say that from the standpoint of, uh, it's the most efficient way to get a variety of compounds that have been shown in science, uh, to help people age better.

[00:02:34] We're going to talk about the science today. We're going to focus on the science, but. My audience knows that I'm not a hyper, but this one, I, I am somebody who pays attention to intelligent design, let's say, and I feel like this is an Intel intelligently designed supplement. And I take it every day and I take it every day because.

[00:02:54] I want to age better. These compounds will help me age better. They're all in one product. It just [00:03:00] makes a lot of sense. So I'm excited about this supplement, understand why with that being said, um, you, you, you kind of drove this products development, correct?

[00:03:12] Erin Sharoni: [00:03:12] Yeah. Um, to sell cell has been in development for a couple of years.

[00:03:16] And so it was really excited to join in and help that

[00:03:19] Carl Lanore: [00:03:19] keep going, talk about what the objective of development was originally.

[00:03:26] Erin Sharoni: [00:03:26] So, um, I joined Viva cell after the initial formulation was, was complete. Um, so of course we're always still working as any good scientist would, you know, to question the mechanisms ensure that.

[00:03:39] We're getting, um, you know, the proper dosage and the proper timing and, and all that stuff. So we have a study going, which we'll talk about later. Um, but you know, w what's what's really important here is how can we help support longevity? This is, this is an adjunct to an already healthy lifestyle for people who are already aware of how to [00:04:00] support their health span and lifespan.

[00:04:02] Um, and so the thinking behind it really was while there has been this, like, Massive, um, onslaught of research in the last 10 years into human health and longevity. And on the longevity side, there's been a couple of compounds, um, that I know you've talked about at length with different people on the show about, um, but it has been shown to support life span and or health span.

[00:04:25] And so our thinking was, well, you know, how can, how can we take all of those and amplify the effect?

[00:04:34] Instead of yeah, 10 different bottles and yourself. And if you're like me, you know, you probably have a whole bunch of different supplements and entire cabinet maybe dedicated to it. So, right. So Judah cell, um, aims to only include those ingredients, which obviously may change as research, you know, comes to light over time.

[00:04:51] But to date the ingredients that, um, are most heavily studied. Are known to be safe and efficacious in terms of, um, supporting [00:05:00] lifespan

[00:05:00] Carl Lanore: [00:05:00] and health span. So when we talk about, um, supporting both lifespan and health span, we have to talk about the, uh, observations and introduction of senescent cells. We've had Dr.

[00:05:14] Miquel black Colonia on the show that a lot of people on the show talking about what senescent cells are and. How to rid the body of them. And as you point out proper sleep critical, uh, uh, diet appropriate for you. Cause that th that varies, I'm not, not a, not a one diet fits all person. We know that microbiome is unique, different diets work for people.

[00:05:45] You have to look at. Biofeedback. Like, if you feel good after you eat a certain food, it's probably better for you than if you feel horrible. Um, but with that being said, the appropriate diet, proper sleep hygiene activity, uh, [00:06:00] these three hallmarks. Have lifestyle play a role. And as you point out a supplement can only enhance that.

[00:06:09] So, and I know that you, you want to make sure that we tell people that, Hey, you can't, you can't live a horrible lifestyle, eat the wrong foods, stay up all night and take a pill. And it's going to correct your bad decisions. But if you aren't already doing these things, these compounds will help address senescent cells.

[00:06:26] Right. Is that what we're talking about here?

[00:06:29] Erin Sharoni: [00:06:29] Some of them. Yeah. So we can get into, you know, which I'd love to discuss these nine hallmarks of aging and, um, the information theory of aging and, and all of these, these neat things that we can cover over the next hour. But with regard to senescent cells, one thing that I will say that, um, I'm sure your prior guests have talked about, but just in case anyone listening, isn't quite aware of exactly.

[00:06:48] What's an essence cells are what their roles are. Um, you know, the, the evolutionary mechanism and the fact that. Ridding your body of cellular senescence completely is actually not a good idea. [00:07:00] So just as with anything, right. Um, it's it's you don't want to completely eliminate a process that hasn't been evolutionarily conserved because there's a purpose now.

[00:07:11] It's interesting because essence for anyone listening to me, isn't mature, um, it's irreversible, um, cell cycle, cell growth, the rest, right? So, so essentially it's like a break mechanism that the body goes. I'm detecting DNA damage or, you know, telomere absence or shortening or some other disruption. And then the body is able to smartly say, well, I don't want these cells to proliferate, right?

[00:07:35] Because these are damaged cells. Why would I want them to divide and proliferate and turn into something that is potentially cancerous or there's going to cause other diseases. Right? So this mechanism of cellular senescence says halt, and that's a good thing. Consider, um, you know, stopping the proliferation.

[00:07:53] Of damaged cells, but there's this concept in biology called antagonistic pleiotropy. And so. Very [00:08:00] crudely. Um, the idea is that there's like an expiration date, right? And, and, and, and things that are beneficial to the organism in youth or in reproductive years may not be so beneficial as time goes on. And so what happens with these senescent cells is that as you accumulate more and more, let's say double stranded DNA, right?

[00:08:20] And more and more mitochondrial dysfunction and shortening telomeres and all of these things that happen naturally over time with age and exposure to various extrinsic stressors and intrinsic stressors. Um, you, you would have naturally more cellulose. So in essence, if the body is working correctly, it's going to say, hold on, I got to stop all this damage.

[00:08:37] Now what happens is that the senescent cells, as I'm sure some of your audience knows, tend to just sit there. And they kind of wallow, right? So some people call them zombie cells. Um, but again, very crudely, they, they stop proliferating, but as they sit there, they secrete the sass and the senescence associated senescence associated secretory phenotype.

[00:08:59] I think I'm saying that [00:09:00] correctly. Um, but it's capital S a S P SAS. And so essentially, you know, it's sending out signals. Cytokines, inflammatory signals, all sorts of stuff that can cause other cells around it. Yes. Now, in some sense, we might say, well, that's good because if this one sells dysfunctional here, there might be cells around it that are also misbehaving.

[00:09:18] Right. But there also might not be, there might be healthy cells. And so what happens then is you have this. You know, this accumulation of these inflammatory markers and that's not great. And that happens over time. And so that's why something that might benefit the organism younger CSUs to be benefit, you know, maybe yeah.

[00:09:35] As you age. And so this idea emerged of, Oh, well, let's create these, um, you know, Cento therapeutics, meaning how can we clear the body of these pesky senescent cells that are just sitting there? So clearing the body of a senescent cell is, is one thing. And you really have to take something quite regularly for that task, because you're always accumulating these senescent cells and to date, you know, uh, we don't have something that you can just take and we'll always written, you have these senescent [00:10:00] cells, and again, sometimes it's serving a purpose sending signals appropriately and sometimes not.

[00:10:04] Um, and then there's the idea of. You know, how do we stop Sydney? Some people say, well, how do we stop senescence completely? Which obviously is not a good idea because you don't ever want to completely stop that process. So, um, back to, you know, something like, like Gibby cell, which does contain. Um, at least one potential cent alytic ingredient, which is five to 10, which we can talk about a bit later or now, um, you know, that w w w what a Senate analytic ingredient would be doing, ideally is ridding the body of those senescent cells, um, and doing it and doing it effectively.

[00:10:38] But, but interestingly, natural compounds that do have some analytic properties. Um, actually also have lots of other great properties, right. As you can imagine, they're, you know, anti-inflammatory antioxidant anti-Trump Magenic, um, antidiabetic in some cases, so they have all of these other mediating properties that are helping, um, the body maintain [00:11:00] homeostasis, uh, and be in a state of health and then may or may not also assist in the clearance.

[00:11:06] And the senescent cells. It's

[00:11:08] Carl Lanore: [00:11:08] interesting that you talk about antidiabetic because while everybody's all wrapped up in suppressing M tour, which is not a good thing we've learned on this show, that memory formation requires M tour. That muscle repair requires M tour. That bone repair requires M tour and everybody's driven like, Oh, we just need to shut off M tour and we'll age better.

[00:11:30] And it's kind of like the same thing that you just said, like, you don't want to just. Eradicate all senescent cells, they serve a purpose and you don't want to just suppress all mTOR because it has, it serves other purposes. But the funny thing that you just hit on that we need to revisit for a second. I did a show, uh, probably in 2006 or 2007, uh, with a scientist from the, uh, Albert Einstein school of medicine.

[00:11:58] I can't remember his name now, [00:12:00] but the, the show was titled. Glucose signaling is what speeds senescent cells. And so everybody's so focused on mTOR and amp K, but what they failed to realize is that the thing that actually turns us acquiescent cell into a senescent cell is improper blood sugar management, constantly raging blood sugar.

[00:12:26] And you just talked about. Antidiabetic so let's talk about the anti-diabetic compounds, uh, in, in Juba cell for a second.

[00:12:35] Erin Sharoni: [00:12:35] Well, just really quick, I would say it's, it's not, um, you know, with regard to something like, like ameture you're right. You don't want to completely suppress something that again has been an evolutionarily conserved mechanism and does serve a purpose.

[00:12:49] I think the idea behind that and, and rightly so why people focus on it now is because. The lifestyle or at least the Western lifestyle that people lead. Um, you know, [00:13:00] you're, you're really upregulating inventory way, way too much. And that may be a whole other conversation.

[00:13:05] Carl Lanore: [00:13:05] It fits, it fits nicely into this discussion actually, because what we're really talking about is people who eat around the clock and especially people eat late at night.

[00:13:14] They are constantly turning M tore on all day long, as well as raising blood sugar. So those two things kind of go hand in hand.

[00:13:23] Erin Sharoni: [00:13:23] Yeah, and I, and I would also add protein. Um, so there's a lot of, a lot of great research, um, that, you know, has been around for a long time and, and also some, some more recent, um, studies, a really interesting epidemiological study, um, that was, uh, Partly, I think Harvard and partly from Tiran university, if I'm getting that right.

[00:13:42] But, um, I can cite the study. I have it somewhere in my notes, but it's interesting because it actually does show that, you know, reduction of protein, specifically animal protein, um, is correlated with a better outcome. Um, you know, in regulation, um, of [00:14:00] mTOR. And so again, enter is not totally bad. Eating protein is not totally bad, but eating excessive amounts and depending on when you're eating it and where is it coming from and what is the quality?

[00:14:12] Um, all of these things in addition to enter individual variation really matters. So, so again, like I'm always stressing that, especially even with, you know, a supplement that I really strongly believe in like juvenile, which I think is, you know, is, is, is, um, I'm really proud of to be working on, but again, uh, there is no, uh, Hey, take this or do this and it will make up for all other poor choices.

[00:14:37] Right. You know? Um, Th th there's a lot of lifestyle choices that people just sort of default to maybe not realizing that it's not the greatest thing for their, for their health and longevity and that's for a variety of reasons. Sometimes it's because of marketing sometimes it's because of, you know, um, cultural assumptions.

[00:14:54] Um, but the nice thing is that we can read studies and we can learn and, and, you know, we, we, we can adjust. Um, [00:15:00] so again, it sort of comes back to that point that you, you. Nicely brought up in the beginning, which is that, you know, we see something like June cell or any of the ingredients in it to be sort of Agilent therapy.

[00:15:10] Right. To, to, to a healthy lifestyle and diet and sleep. And all those things are incredibly

[00:15:15] Carl Lanore: [00:15:15] important. What compounds in Juba cell actually helped, uh, stabilize blood sugar. I know which one it is. In fact, it was compared to Metformin in a study once and showed that it worked better at regulating blood sugar than Metformin.

[00:15:28] And Metformin is the, is the gold standard for, for diabetes medication, which is resveratrol. Um, so there's resveratrol in juvenile, right? Yes,

[00:15:38] Erin Sharoni: [00:15:38] there's resveratrol and there's terrorist still being, and again, I know your audience is very, very well-educated, which is awesome. Um, so we probably don't have to

[00:15:46] Carl Lanore: [00:15:46] no, no dive in any way.

[00:15:47] We have new listeners. Yeah. We have new listeners all the time dive into it.

[00:15:51] Erin Sharoni: [00:15:51] Yeah. So, so I think probably most folks have heard about resveratrol. Right. Um, and it turns still being as nice because. Um, unlike was Veritone three [00:16:00] hydroxyl groups. Um, Tara Sylvia has one, and that means that, uh, the model is essentially around, longer in the body.

[00:16:07] So one problem with resveratrol and with a lot of polyphenols is bioavailability. Right? How long does it last? It's getting broken down in the liver really, really quickly. Um, the jury is still out on whether or not it's the reservoir trial. Or still be, or their metabolites, the byproducts after the breakdown that are responsible for the beneficial effects, but regardless of how fast it was virtual, it is broken down.

[00:16:31] Um, there are still plenty of studies showing evidence, um, that there's positive effects in vivo. So exactly. What is driving that, you know, maybe it's still a little bit TBD because again, it's this debate between the metabolites or the actual compound or whatever, which is not necessarily that important for the context of this conversation.

[00:16:51] But yes, it was spiritual enter still very closely related. And when you combine them, You have, um, an even more [00:17:00] powerful effect that's also been shown. And so that is why we put both of those ingredients in Juba cell. Um, and so, you know, you brought up Metformin, um, foreman is an interesting one. Also there's a little bit of controversy around that, right?

[00:17:12] Um, yes, it has beneficial effects. Um, there's also, you know, somebody said evidence that it has really not. So,

[00:17:21] Carl Lanore: [00:17:21] so, so, so, so I have been anti Metformin since its inception. And use as a, of lytic. And it's because of the research that I've read about it. Well, it's interesting because both Dr. McKell blaggers Colone and both Dr.

[00:17:36] Peter Attia have now come out and actually agreed with something I've been saying for, I don't know, eight years now. Uh, and that is that Metformin only works with people who are already metabolically deranged. If you, if you are, if you are metabolically flexible, And you have a healthy level of insulin sensitivity, Metformin contributes, nothing good, and actually may cause [00:18:00] other problems by blunting, uh, the important M tour MTRC, which is what helps you recover from workout to workout.

[00:18:09] And so you won't get the muscle, the new muscle gains, the new muscle creation, or even the maintenance of muscle, um, and Metformin, not only sensitizes, uh, Uh, well, let's say Metformin increases insulin's effect on all tissue, including fat. And if you look at people who believe that Metformin is the way to go and they eat even a moderately standard American diet, they just get fatter and fatter and fatter.

[00:18:38] So I I've never been a Metformin fan. In fact, I've always said resveratrol is a better choice to Metformin because it doesn't do the things that Metformin does not to mention it alters. The gut microbiome and not necessarily in a favorable way, depending on your diet, Matt, I've never been met with Metformin.

[00:18:54] People used to jump on me about Metformin and now all of a sudden geniuses like Peter Tia and Dr.  [00:19:00] gone. Yeah. You shouldn't be taking Metformin unless you're really sick already.

[00:19:04] Erin Sharoni: [00:19:04] Yeah. I always thought the Metformin hype was, uh, interesting. I won't say good or bad. Um, But anecdotally my own experience. And again, this is an anecdote.

[00:19:13] This is not, you know, anything that was derived from a study. My own personal experience was, um, very poor with Metformin. Now I didn't take it for anti-aging purposes. I took it to address a particular health problem that we thought I had had, uh, seven or eight years ago. Um, and you know, I researched it and Metformin is supposedly very safe and highly efficacious.

[00:19:35] And so I thought, okay, I'll try it. And I had. The worst experience with the strike. And I remember going to my physician, um, who, you know, was very well-intentioned individual, but clearly wasn't that educated. PR particular, um, drug and said, uh, you know, listen, I, I I'm getting the opposite effect. My blood sugar is spiking.

[00:19:56] And by the way, I never had blood sugar issues. I was taking this for, um, [00:20:00] polycystic ovary.

[00:20:00] Carl Lanore: [00:20:00] I knew it. I wasn't going to ask you if it was cos I know it.

[00:20:03] Erin Sharoni: [00:20:03] Yeah. I didn't even have it. And by the way, I was able to mediate those symptoms with appropriate dietary changes. That's another conversation. But, uh, regardless, you know, I, I.

[00:20:12] I, I was like, this is a really bad experience. And so I started looking into it and I realized, well, one problem is that Metformin may affect females differently. Now there's a huge issue. When you talk about, um, you know, how clinical trials have been conducted generally

[00:20:28] Carl Lanore: [00:20:28] zero zero, zero, zero female, female rodents, zero female patients because of that course of that pesky estrogen hormone,

[00:20:38] Erin Sharoni: [00:20:38] confounding variable.

[00:20:41] It might be confounding, but it's circulating in an all female. Right? Right. I mean, that's, I shouldn't say all because there's instances in which you might not have much estrogen, but, um, you know, generally speaking women are dealing with yes. Different hormonal profiles. And what I learned very quickly, uh, was, [00:21:00] wow, this is really sad state of research.

[00:21:02] And, you know, there are scientists who speak up about it. I really hope that it's going to change soon because. Um, obviously it's something I care a whole lot about as a, as a female, but also as like a student of science. Right. But how are we, how are we recommending things and saying that they're safe and efficacious if we're only testing and if 50% of the

[00:21:19] Carl Lanore: [00:21:19] population, and you know, it's funny about big pharma, we've actually done shows about this.

[00:21:24] Cause there's one of the first studies to come out with probably about six or seven years ago that showed that they don't use female rodents in rodent studies because of the pesky hormone estrogen. And they get, they get. Undesirable outcomes. Well, wait a minute. Maybe it's undesirable for the scientists, but maybe means something for women.

[00:21:42] Um, but big pharma recognizes that the microbiome diversity. Also alters drug effects. When they make a drug, they tested in India. First, they texted in the United States. They realize, Oh, it doesn't work in that marketplace because the people have different [00:22:00] microbiome. Well, if they can do that, why don't they include women in research?

[00:22:04] It's just, it's just to me, it's asinine. I gotta be honest with you.

[00:22:08] Erin Sharoni: [00:22:08] That's the word I would use with my friend, Carla. I am completely, I know that's not what this particular episode is about, but it's a big pet peeve of mine and it should be a pet peeve of anyone you're an intelligent, you know, that cares about, uh, the cares about health and wellbeing.

[00:22:22] Um, so yeah, anyway, so, so I digress. But I, I like you, I was always a bit skeptical of net form. It looks, and it works. In some instances it works for some people. Um, but again, it was, it was developed for individuals who already had existing issues and who are ill. Um, and I. I don't think that it's, uh, outlandish should meet to suggest that for some of those individuals who have, for instance, acquired type two diabetes, then you don't need Metformin because there's many studies showing that when you adjust your lifestyle and diet appropriately, um, Type two

[00:22:56] Carl Lanore: [00:22:56] insulin resistance, insulin resistance, reverses, and [00:23:00] you become insulin sensitive again, but that's too hard for people to do.

[00:23:03] Um, but, but I I'm being facetious, but the reality is that the things like per se and, uh, and, and, and resveratrol work on the, uh, anti-aging, uh, longevity, uh, health span, uh, continuum in a completely different pathway. Uh, then say , which brings me back to my original statement. When you look at a product that's well thought out, it doesn't just go, Oh, this is the only thing.

[00:23:33] That's an insult to the complexity of the human body to say, this is all you need. There are several things that need to be stacked that work from different directions that end the end result is the same thing, which is better aging. And. The idea that Juva cell has taken a completely different approach and said, you know what?

[00:23:54] We don't want to just be the one thing we want to be the all things. These are the things that [00:24:00] supplementally would be great adjuncts to a healthy lifestyle, good sleep. Th th the appropriate diet. This is going to help you. I want to, I want to put up this banner, uh, real quick. Also, if you go to SHR network.biz/live better.

[00:24:17] And use the code SHR you'll save 20% off your first bottle of Juva cell. And this is not something you're going to feel. Folks. Um, I take Juva cell every day now, and I don't feel anything. This is something that you take every day and trust in the science and understand that your outcome will be better than if you didn't take it.

[00:24:43] I take rapid myosin, six milligrams a week, uh, one day a week. And I do that and I don't feel anything. I don't expect to feel anything, but the outcome is something that will unfold over time. So this isn't a supplement you're going to take. [00:25:00] I mean, they could have added a little caffeine and you would have went.

[00:25:02] I think it's working. I feel something, but it's not that kind of supplement. Uh, we're going to take a quick commercial break. When we come back, we're going to talk about more of the science behind Juva cell, but again, go to SHR network.biz/live better. Use the code SHR and save 20% off your bottle of Juva cell.

[00:25:20] We'll be right back with more stations.

[00:25:25] Welcome back. So, you know, I went gray for COVID those of you watch show now, and I'm really debating about coloring my hair again, because when I was at Aaron cinnamon's house for new year's Eve, um, there were a bunch of young boys there and, uh, one of them came down in the morning and asked if I was the grandpa.

[00:25:44] And I said, no, I'm not the grandpa. And they said, well, he said, well, you have gray hair in an old face. And I can't do anything about the face, but I could do something about the hair. So what should I do? Should I start coloring my hair again? Email me at, on This email address is being protected from spambots. You need JavaScript enabled to view it.. And tell me what [00:26:00] you think also, did you hear the secret word?

[00:26:03] It was in the last spot, the last commercial break, but it will be up again. So keep listening, send a secret word to on This email address is being protected from spambots. You need JavaScript enabled to view it. and you are entered to win a box of. Tasty pastry, the birthday cake, tasty pastry from legendary foods. We've given away a box a day. So your odds are good. We're here with Aaron Cerrone from Juva cell.

[00:26:23] We're talking about juvenile, which I take daily because I'm hedging. My bet. I want to age better. And I'm doing a lot of the things, right. I go to sleep every night at nine o'clock. I train five days a week. I do cardio first thing in the morning. Um, I, I pay attention to my diet. I'm wearing a continuous glucose monitor because I've been experimenting with my diet for the past two weeks.

[00:26:45] And I'm looking at what foods keep me stable, what foods knock me off. And this is worthwhile by the way, anybody out there, if you really want to, most of us eat nine to 11 foods a week, the same ones. [00:27:00] You can learn real quick, which foods are working for, which are, and if you just put a continuous glucose monitor on for two weeks, but I'm taking this and so's Alisa, I'm also taking, um, um, uh, rap myosin once a week.

[00:27:13] Why? Because I want to hedge my bet. I want to age better. Let's talk. But some of the other things that are in Juba cell, so we can discuss this stacking and this different way of helping us age better.

[00:27:27] Erin Sharoni: [00:27:27] Yeah, sure. Well, first of all, I'm very glad that you, uh, that you like our product and that you're taking it every day.

[00:27:32] So, uh, we, we appreciate that endorsement. Um, and the honesty of course, because you know, people often do ask, um, I'll get messages on Instagram or something saying, Oh, what should I expect to feel when I take you to? So, and, and in all honesty, it looks, some people might feel something, you know, it's anecdotal and it varies from person to person and it might depend on.

[00:27:51] You know, how sleep deprived you were or what your particular state of health was or what your body needed more help with. Now, you are someone who has already taken a lot [00:28:00] of, uh, supplements that, that benefit all of these different pathways. Right? And so I'm presuming that you're doing a lot of these things right already, but, but some people might not be in.

[00:28:08] So, um, you know, it's really, it's, there's really inter individual differences. Um, anecdotally, you know, the first time I actually took the supplement myself, um, I felt a very slight. Uh, a very slight increase in mental sharpness in cognition, obviously like for me in my line of work, it's really important.

[00:28:26] And it's something that I noticed, right. It was like, huh, like a little bit of that brain fog has gotten now. I would not make the claim that  makes you smarter because that's, I don't think any supplement should ever say such a thing. Um, but you know, you might feel something, um, that you're able to articulate.

[00:28:42] So, and, and for my sister, um, you know, for her, it was noticeably more and more energy and a couple, a couple of other things that had to do with, um, interactions, um, benefiting another condition that she had, which again, it's. Private, so I won't discuss it, but, um, it's something worth probing. And so it's something I, I kind of broke down and said, well, let me [00:29:00] look into this.

[00:29:00] The point of payment, like different people will have different experiences, but everyone should recognize that these supplements do work at the cellular level. You know, if you just took resveratrol, uh, by itself off the counter, would it be beneficial? Yes, probably depending on the quality of that resveratrol.

[00:29:15] You took it with some fat because it's like, well, Felix, we need fat, uh, to, you know, to get the most out of it. But, but you probably wouldn't feel anything different. Now over time you might notice something, but you also, it might, it might just be an absence of an aging phenotype. Therefore you might not say, Oh, you know, my wrinkles have disappeared.

[00:29:33] Well, they're probably not going to disappear. They're there already, but they might not get words. And more importantly than how you look. Is how you feel. Right. And, and, and how, you know, how has your strength over time, you know, do you become less frail with age? Um, you know, how has your nutrient sensing and actually that's something that I'd love to touch on.

[00:29:52] Um, Carl, I don't know if any of your prior guests have really gone into those, um, hallmarks of aging. But I think it's [00:30:00] a really important thing, um, to understand like foundationally, when we, when we think about aging and we talk about, um, the ingredients in, in, in juvenile and other supplements that are addressing these things, because really, um, there are these nine main hallmarks of aging and they were originally described in a paper in 2013.

[00:30:18] I'm forgetting the surname of the, of the, um, lead author. But, um, if you, if you Google it, you put into pub med night. And hallmarks of agent 2013, you'll find it. Um, and this was just the, the paper that first described it cohesively, not the first people to ever think of any of these things. Um, and so what they, they listed that there as, um, Genomic instability.

[00:30:40] So that's due to DNA damage, right? Uh, telomere attrition. So the shortening of your end caps, uh, epigenetic changes, uh, loss of proteostasis. So that means, um, the protein machinery in the cell is. It's you know, failing and you're accumulating a lot of these misfolded proteins. So that's a root cause of a lot of age-related diseases.

[00:30:59] Things like [00:31:00] Alzheimer's that people want to avoid, um, deregulated, nutrient sensing. So that's something that we sort of just touched on. So insulin sensitivity as you age, right? Um, mitochondrial dysfunction, STEM cell exhaustion. So this idea there's a finite amount of these STEM cells, um, uh, intracellular communication.

[00:31:19] Being changed. Um, and then of course, cellular senescence, which we talked about. And so the two things that, you know, I think are important to talk about here, when we talk about some of these ingredients that most folks could probably wrap their, their, their heads around also quite easily is cellular senescence, which we spoke about where the commercial break and this idea of, uh, genomic instability.

[00:31:39] So you're constantly accruing these double stranded DNA breaks, right? So you can't avoid, uh, having. Having damaged DNA. That's just something that happens in, and we've evolved with cellular machinery to be able to repair those breaks. Even these double-stranded breaks, which are damaging. Right. Um, the problem is that [00:32:00] as you accrue more and more of that damage over time and or with increased exposure to intrinsic or extrinsic, Environmental stressors.

[00:32:09] So extrinsic might be things like, you know, chemicals, uh, poor dietary intake, intrinsic might be, um, you know, uh, high levels of stress, um, poor, poor, poor sleep causing cortisol, dysregulation, and disruption of the circadian rhythms. So as you have, have all of these disruptors coming in, you can imagine that you will then be accruing more and more of these.

[00:32:30] These mutations and this DNA damage. And so like anything like any machine, uh, somehow some at some point that machinery is going to say, okay, I'm too busy repairing all of these, these DNA rules, right. This is Davidson Claire's, uh, uh, information, third aging crudely. We can discuss that as well, but essentially saying, okay, you've gotten these, uh, you know, sirtuin right.

[00:32:51] They're responsible for helping to repair all of this DNA damage, but they also have other jobs. And when they're distracted doing all of this, they can't go back and [00:33:00] do the rest of their job. And then, you know, you, you, you accumulate these sort of, um, all this aging phenotype manifests and we see aging, we see frailty, we see wrinkles.

[00:33:10] We see, you know, um, uh, all these, all these other things would be associated with aging. And so, um, when we talk about, for instance, DNA damage repair. Uh, two tunes obviously are really important. So again, if you have an educated audience, I'm assuming most folks know what that is, but in case, in case they're not familiar with it, uh, they're a family of proteins that are really important in regulating cellular health.

[00:33:32] So they have a really important role in all of these different processes that maintain. You're your body's homeostasis at a cellular level. So, um, you know, your metabolism on neuronal function, stress resistance, circadian rhythm, all of these things are, are inflammatory balance, right? Uh, cell growth, all of these things, um, are, are in part, um, Uh, regulator supported by sirtuins and so polyphenols, which is what is in Juba cell.

[00:33:59] So things like [00:34:00] resveratrol and, uh, green tea extract and her still being and curcumin, and FYSA 10. Um, these are polyphenols that we find naturally implants, um, and they activate sirtuins. Um, and so that's really important for aging because it's involved in DNA damage repair. Right. Um, so, so I think. You know, when we start talking about ingredients like resveratrol and Tara still being, which we said prior to the commercial break, that in combination, um, are really important because they alter the epigenetic expression of some of those DNA damage response genes, um, specifically in one case

[00:34:41] Carl Lanore: [00:34:41] And the instinct thing about that is soda's time restricted feeding. Exactly. You know, something because I would love for you to opine in what I'm about to say, but I think that intimate and fasting, uh, is being done wrong today. Um, your first [00:35:00] meal is part of the trigger for circadian rhythm, just like sunlight is so you get out in the day, the morning you greet the sun or the sky is changing colors, but eating that first meal.

[00:35:12] Is another one of the cues to tell your body it's daytime, wake up. It's going to be busy. I think that the right way to do time restricted feeding is start eating earlier and stop eating earlier. So your body is completely done with digestion. By the time you get to bed and you actually have better sleep, I would love for people to flip the script on, on intermittent fasting and not.

[00:35:37] For go breakfast and lunch and Jessie dinner, because that isn't going to support energy production because you're missing the cues of eating in the morning. So start eating earlier, but stop eating earlier, stop eating at five o'clock and, and have the rest of the night. And he thoughts on that.

[00:35:58] Erin Sharoni: [00:35:58] Yeah, so I believe, [00:36:00] um, and I won't be able to recall the study, but I know there's at least one study done looking at exactly that.

[00:36:05] And if I recall correctly, they didn't really find a statistically significant difference between intermittent fasting, where you, you know, eliminate breakfast and start eating at, let's say noon, um, and intimate and fascinating where you do what you're suggesting, which is, you know, you eat earlier in, you.

[00:36:21] You stopped eating earlier. Um, even though intuitively it makes sense, actually, when we talk about circadian rhythm at the cellular level, um, the, the, the strongest driver is actually light. Right. Um, and so, so actually the best thing you can do is to get up and go outside and not put sunglasses on Matthew Walker talks about that.

[00:36:41] Right. Um, that's why folks who work, do shift work and people who work at night, you know, have a lot of, have a lot of problems and, and, and, and, you know, um, have. Poor morbidity mortality outcomes. So, so yeah, I know that that, that intuitively makes sense, but actually I think that the science is not yet or did that again.

[00:37:00] [00:36:59] I can be wrong, but if I recall correctly, because that was sort of what I thought is flown, then I thought, Oh, that's inconvenient for me just because it just, because the way my schedule is, and there's something, you know, that you said actually earlier, I think in the introduction to the show, which is being in tune with the body.

[00:37:15] And I think that if you wake up. And you're starving. And now we're talking about someone, who's got a healthy diet and lifestyle, not someone who eats egg muffins for breakfast, right? It's lots of sugar, that's, that's a different situation, but all things equal. If you have a relatively healthy diet and lifestyle and you wake up in the morning and you're really, really hungry, you know, and then yes, restrict your feeding so that you stop eating, uh, earlier in the evening.

[00:37:41] Um, but if you wake up and you're not hungry, Which, which I, for instance, often I am not. Um, I think then, and then don't force yourself. Um, it's, it's you're right. That it's bad to eat very late. That is true. That's been, that's been shown, right? You don't want to eat right before, um,

[00:37:57] Carl Lanore: [00:37:57] before bed, three [00:38:00] hours, according to a doctor, um, uh, Dale Bredesen, who's been on the show a couple of times that, you know, you you're promoting the development of metabolic debris in the brain.

[00:38:13] So

[00:38:13] Erin Sharoni: [00:38:13] three hours. Yeah, that's the, that's the ideal, but you know, you all, we also have to take into account that like people's lifestyles are cumbered by various things, you know, you might be taking care of an elderly parent. You might have a rowdy kids. You might, you know, have to work late. I mean, look now with COVID and people working from home and kids being out of school, that's a whole other issue that we're going to see the fallout of that for many, many years to come because it is changing.

[00:38:38] People's circadian. You know, uh, schedules with Rebecca. Yes, exactly. So, so, so I think there's a couple of things there, and I do think that overall, what the science does. The evidence does support is restricting your feeding and eating less frequently will benefit you. So if you can do that in the morning, great.

[00:38:58] If you can do the new evening, [00:39:00] great, but just do it one way or the other, you know, compelling evidence saying otherwise that I'm kind of okay with saying we'll do it either way and make sure you're not eating right before bed, because we know that that. That's not great. Um, so that's my opine on that call.

[00:39:15] Carl Lanore: [00:39:15] It's great. I'm experimenting with it now. So I'm eating first thing in the morning and, um, I've always stopped eating at six. Now I'm stopping around five and as a result, I do wake up hungry in the morning. I think that you got to prime the pump in order to have hunger in the morning. If you, if I, if I'm already fasted by 6:00 AM in the morning, I'm already fast at 14 hours, then chances are I'm going to be hungry as opposed to if I have my last meal kind of late, and it's a big meal, and then I may not be hungry first thing in the morning.

[00:39:45] So it's something that people need to experiment with and see how they feel about it. I'm experimenting with it right now, but I still. Uh, observed time, restricted feeding. I mean, I, I wake up every single, so I used to check my, uh, ketone levels when everybody was all, you know, [00:40:00] into ketones. And after 12 to 14 hours of fasting through my sleep, I'm at 1.2, 1.4 millimoles.

[00:40:08] So I'm highly metabolically flexible. My body will start producing ketones very, very quickly because I have done time-restricted fast, a feeding for so many years now. Uh, but it's something that people have to play with. They have to experiment with it.

[00:40:22] Erin Sharoni: [00:40:22] Yeah. You know, I think monitoring your blood glucose is, is, you know, can be a great idea.

[00:40:27] Whether you have a continuous monitor, like, like you and you can do some really in-depth experiments or. You know, I remember years ago, I just bought one of those from CVS, you know, just a regular glucose. Yeah. Monitoring kit, where you prick your finger. It's kind of uncomfortable. But, you know, I actually had done some experiments where I said, okay, let me, let me play with these time restricted feeding windows.

[00:40:46] And what I noticed was that my morning glucose. And I actually tend to have, I'm very lucky genetically, we don't have any diabetes in the family and we have really well controlled blood sugar that that's just partly luck of the draw. And also the fact that, you know, I live a healthy [00:41:00] lifestyle, but, um, but I noticed that my normal, my normal fasted morning glucose reading.

[00:41:07] You know, it was about 70, between between 70 and 78 depending. Right. I tend to be a little bit on the, on the lower side. Um, genetically that's just runs in my family. Um, but when I would restrict my, my feeding and I would fast, I think I forget the exact number, but it was something like 15 hours or more.

[00:41:26] My glucose would go through the roof and I was waking up with 115 fasting glucose. And I was like, Whoa, Whoa,

[00:41:31] Carl Lanore: [00:41:31] Whoa, this is not right. Right. And that, and that's what the body does. The body. One of the things that I've noticed is there's several events in life. Like, uh, if I train fasted, my blood sugar goes up during exercise and rightfully so because my blood sugar has to meet the challenges and the demands that I'm putting on it.

[00:41:51] There were other events that make your blood sugar go, um, right. So it's not, it's not all bad, old. Good. That that's the bottom line [00:42:00] here. Right.

[00:42:00] Erin Sharoni: [00:42:00] And also again, we must take into account sex differences. So for women who are not menopausal, you know, you have a monthly fluctuations in your hormone levels and that can affect hunger and satiety that can affect, uh, energy that can affect cortisol.

[00:42:16] Um, and so just like we talked about with the unfortunate, uh, you know, foreman, political trial results from it, foreman, not, you know, not being trialed. Initially, at least in women as much. Um, I think that's important to take into account as well. Um, you know, if, if you're, if you're female pay attention to where you are in your cycle, when you're doing time restricted feeding and, you know, see how that makes you feel, see how your body responds, because like you, I also do believe, um, that to some extent it is, you know, we are intuitive.

[00:42:47] Yes, you need to test and you need to see doctors, so you can't just run blindly. Um, but if you really strongly feel that something is not making you feel good and pay attention to that, so different than someone saying, well, kale doesn't make me feel good because I like eating [00:43:00] McDonald's right. I'm not talking about that.

[00:43:01] Carl Lanore: [00:43:01] So we have to take a break. I'm going to plug the product again, but I have to read a message. I got on Facebook from a guy named Kirkland. Who said that lady you have on basically sells Juva cell. She looked like she's in her twenties. So are you in your twenties, Aaron?

[00:43:18] Erin Sharoni: [00:43:18] No, I'm not, but my biological age,

[00:43:21] Carl Lanore: [00:43:21] there you go.

[00:43:22] That's that's, that's what he said. So he knows that he's talking about, let me just

[00:43:26] Erin Sharoni: [00:43:26] thank you for that user

[00:43:28] Carl Lanore: [00:43:28] branding backup here. So everybody knows, uh, the product is called Juva cell. We're talking about it today. SHR network.biz/live better. Use the code SHR for 20% off it, you know, you're never too young.

[00:43:41] To start aging better because it's easier to maintain than it is to reverse. And this product should be viewed as an essential for anyone in their thirties or older, uh, because you will just age better. You won't need, maybe you won't need that facelift at 50. Uh, [00:44:00] maybe you'll maintain the way you look right now into your sixties.

[00:44:04] Again, SHR network.biz/live better. Save 20% off using code SHR. We'll be right back with more superhuman radio.

[00:44:16] Welcome back to super Yuma radio. We're talking with Erin Cerrone from Juba cell. It's a product that I love a product that I take and I take it because I'm going to take it for a long time. Because that's how this stuff works. This is not caffeine. You're going to feel it five seconds later, it's gonna help you blast through your workout.

[00:44:34] Um, so there's one player in Juba cell that had I not done a show about the research just a couple months ago. I would say, why is glucosamine in there? Talk about the research on glucosamine because that's one that people are like, what, wait a minute, what does this have to do with anti-aging and longevity?

[00:44:55] I'm

[00:44:55] Erin Sharoni: [00:44:55] curious, what show, who did you have on

[00:44:58] Carl Lanore: [00:44:58] your show? I had the, the author, [00:45:00] I had an, Oh, I'll send you the link. I had the author of the study that showed that, um, when they looked at epidemiological research on the presence of Glucosomine, uh, and those people lived longer and they were healthier and it was like, it was like 60,000 or 120,000.

[00:45:20] People in that study. So it was the statistically significant. And you know, I tried to push him, like, why do you think it works? I have my own theories, quite frankly, to have to do it soft tissue. I think we, we think soft tissue is just. Oh, it's just there to hold everything together. It's actually a communication network.

[00:45:40] It's it's like your nerve soft tissue is the same way. And so I think that anything that increases soft tissue, uh, repair and maintenance, uh, is much more important than just, Oh, my knees don't hurt anymore. But with that being said, he couldn't, he couldn't put a finger on it. So he was on the show not too long ago.

[00:45:58] Erin Sharoni: [00:45:58] Yeah. I'll have to check that out. [00:46:00] Um, I, I'm not, uh, I would say I'm probably not up to date on like the most recent glucosamine research. And so I'd like, I'd like to see what he's saying. Um, you know, but glucosamine has been shown as you cited in quite a few epidemiological studies, um, to be associated with better longevity outcomes.

[00:46:18] Um, there's anti-inflammatory effects there's and, and again, like you said, you know, uh, it's not just about reducing inflammation in a joint, right? This idea of. Yeah, sort of a reductionist approach to it. So medicine has gotten us into trouble over time. It can be helpful. Um, but if something is affecting one particular area of the body, we have to look at what else it's doing.

[00:46:41] Elsewhere. Um, and so if it's beneficial for, you know, uh, joint inflammation and, and, um, as you mentioned, um, soft tissue, which I'd actually like to hear your theory, um, then, you know, we have to understand what's the cellular drive. What's the mechanistic driver there. Um, [00:47:00] so yeah, it's, it's one, I think that.

[00:47:02] You know, people might raise their eyebrows a little bit, and it's certainly not the sexiest ingredient of all of the ones that are in there. Right? Like everyone's talking now about fights addendums, very trawl and, um, you know, even something like green tea, for instance, which I think if you asked the average person who's eaten, you know, non-educated at all on topic of longevity, um, they would tell you that, well, green tea is really good for you.

[00:47:24] Could they tell you why? Maybe not, you know? Um, but a recent study actually showed that. Uh, green tea, um, lowers. Um, I want to say it lowers lymphocytic DNA damage and increases the activity of a specific enzyme that's involved in. Um, Uh, basic Cision repair, um, in, in DNA and lymphocytes. So, you know, someone might not be able to necessarily articulate that, but the more that we look at, all of these compounds, the more reward we look at there, you know, there's the evidence for how they work at the cellular level.

[00:48:00] [00:48:00] We realize, wow, there's myriad effects. Here, you know, um, it's not just for cognition or it's not just for inflammation. Um, but the reason that it's beneficial to all of those outcomes is because it has property X. Um, and again, most of the, the, the, um, compounds in Juba cell are polyphenols. And as we know, those are produced in plants under stress, so that were Masis effect.

[00:48:25] Right. Um, and, and that, that is really important. And that's why, of course it's important to eat lots and lots of plants in your diet. That is unequivocally true. Um, so not eating enough plants in your diet and then taking a supplement, not going to change it. Yeah.

[00:48:39] Carl Lanore: [00:48:39] Not going to change things. So I have some theories about, uh, uh, green tea and why it's beneficial.

[00:48:47] Um, I believe that. Research shows that iron is very harmful when it accumulates in the body. Uh, we see research [00:49:00] from, uh, Paul's all women who stopped menstruating and a lot of the disease States typically associated with men, uh, catch up to them, including, uh, dementia and, um, uh, um, PD Parkinson's disease and so on.

[00:49:17] We have research from women who use birth control and they don't menstruate, but four times a year, uh, we see there's research in their iron accumulations. Um, so iron is rust in the body and it damages everything. And, and, and there's those of us who. Want to continue to eat meat. I D I donate blood. One of the things I do to, to continue to lower my TIBC and ferritin levels, and it works for me.

[00:49:52] Um, but another thing that works is green tea. If you have green tea in your gut, when you eat a steak, you absorb far less iron from [00:50:00] that steak than if you didn't. I think that one of the things that green tea does is exactly that it blocks the uptake. Have too much iron number two, there's uh, something in green tea called epi gala Galactica, chin or something like that.

[00:50:17] I'm not, you know, well, that's been shown in research in humans to be highly anabolic when taken in the large doses. So think about that green tea can actually help you build muscle if you use enough of it. Or you can buy the isolated epi galactic gala K action from tailor made health, which is a pharmacy that advertises on the show.

[00:50:40] But yeah, green tea, green tea is magic and there's a lot of really good research on its effect on the microbiome. So yeah, it is it's magic. It really is.

[00:50:49] Erin Sharoni: [00:50:49] Yeah. Anti-inflammatory anti, you know, anti-proliferative, um, there's a, there's all those anti-D antioxidant. Um, and again, you know, like with anything, I think if you [00:51:00] look at the, um, Societies that consume green tea and large amounts.

[00:51:04] Uh, are they long lived and healthier and have less cancer only because of the green tea? No, there's probably many other factors involved, but that may certainly be one of the factors it's mediating their microbiome. Um, it's mediating specific pathways. Um, and if you are keeping inflammation down, keeping oxidation under control, um, you know, keeping insulin.

[00:51:25] Um, um, there. Yeah, exactly. Um, then, you know, you're going to have better outcomes. Overall health span lifespan will improve because one thing we don't want to do is live longer and not live healthier. Right. Which is what we're doing today is prolonging people's lives and they live in these diseases.

[00:51:45] States. And I don't know anyone that wants, that wants to live like

[00:51:47] Carl Lanore: [00:51:47] that. There was a study where they went into a nursing home. We talked about it on casual Friday, probably about six or seven years ago. And they asked the residents of, uh, of nursing homes. Would you like to live longer? And they were [00:52:00] like, why?

[00:52:00] Like I'm, I'm sitting in a diaper waiting for someone to change me. I don't want to do this for an extra 10 years. And that's really sad. That's really sad to think that death is a, a suitable solution to your agony.

[00:52:16] Erin Sharoni: [00:52:16] Yeah, well, that's the unfortunate outcome. When you have a healthcare model, that's, that's based on reactivity, right?

[00:52:23] Waiting until something breaks and until people are sick and then putting a bandaid on it, instead of saying, how can I support the foundation of health internally? As early on as possible. Not that it's ever too late for interventions. I was tell people that as well. Look, there's a great study. Um, looking at the effect of, uh, meditation and neurogenesis and the microbiome.

[00:52:46] Um, and they showed that just a three month. Meditation retreat. And yes, you can argue that there are, or some confounding variables, like you were on a retreat and you weren't working everyday, thereby your stress levels were lowered. But the idea is that, you know, people who [00:53:00] participated in, you know, regular meditation twice a day for X number of minutes, um, you know, they saw all of these physiological benefits and, and these were not people who were 20 or 30 years old.

[00:53:12] Um, so it's never too late to, to, you know, increase, um, Uh, neurogenesis decrease inflammation. Um, it is possible. We're finding that out more and more. And the nice thing is that a lot of these interventions, as I always say are free. Okay.

[00:53:26] Carl Lanore: [00:53:26] Well, well, don't donating, donating blood has been associated with a greater health and greater longevity.

[00:53:32] Uh, I'm actually trying to get the offer of this very old study on, but we're having a hard time finding her because she's left the university that she was at, but. There's something else that donating blood, does it causes bone marrow to release new mesenchymal STEM cells? So you said earlier, like part of the aging process is like the STEM cells just aren't there anymore.

[00:53:52] Well, if you donate blood, you have a flood of new STEM cells that hit the blood, uh, from the bone marrow that can then be used to repair [00:54:00] stuff.

[00:54:01] Erin Sharoni: [00:54:01] Incidentally, uh, the same thing with, um, with, with fasting as well. So a lot of Valter Longo, his work has shown, right? That you see this, um, um, STEM cell intestinal STEM cell proliferation at a certain point in fasting.

[00:54:15] Um, and if you look at some of the, it might be a bit more controversial, but some of the longer term water fasts, um, they certainly talk about that all the time and, and, and you know, that. Has it been shown empirically to be true now, you know, there might be some controversy over how long you want to do something like that for, but does it induce, uh, you know, proliferation of intestinal STEM cells?

[00:54:35] Yes. That, that seems to be the answer. And so to your point, yeah, there are very simple interventions that can cause the body to react again. I think we always have to, as we talked about balanced in the beginning, ask. How much of a good thing is too much of a good thing. And so, yeah, completely dampening I'm tour and completely eliminating, you know, the senescent response is not good.

[00:54:57] And then, you know, donating too much blood and fasting [00:55:00] for too long. Of course also isn't good. So, right. So everything in moderation, um, but uh, also taking into account, as we said earlier, you know, inter individual differences. Um, different people are at different stages of their health journey. They're at different States.

[00:55:15] We also have different genetic predispositions. So something that occurred to me as you were talking about the fasting is a better evening, the early window, the late window. Um, you know, we have different, um, chronic types as well. So some people are night owls. Some people are early risers that's, you know, um, in part driven by genetics also by culture and preference, but genetics are a component of it.

[00:55:35] And so, um, You know, I don't know if there are any studies looking at an association between time-restricted feeding and chronotypes, it's something I would be interested in if that doesn't exist yet. Um, but that would be certainly interesting, you know, does your predisposition for, uh, uh, going to bed earlier or later align with, um, time-restricted feeding, I'm assuming that it would.

[00:55:57] Um, and maybe that could tell people something about when they, [00:56:00] when they should restrict their, their feeding. Um, so yeah, there are lots of ways that, you know, we can, we can test these things out on ourselves as long as they're safe. Well,

[00:56:09] Carl Lanore: [00:56:09] one of the, one of those ways that's within reach of everyone in my audience is to try Juva cell.

[00:56:15] SHR network got biz slash how you see how I segwayed with that. That was pretty good. SHR network.biz/live better. Save 20% off. Use the code SHR. And you know, there's another reason to try Juba sell because you're supporting the show. We never charged for the information I've had. I have people every day.

[00:56:34] Messaging me and emailing me about how some show impacted them, change their life. Uh, kept them from having their breasts removed because we've done shows about Brocka and how it's not a death sentence. And everyone is different than twin studies. I just got one from a woman, uh, just yesterday about that.

[00:56:53] Um, the show is free, but it's really not free. The sponsors make the [00:57:00] show possible. The sponsors allow me to come and do fascinating interviews with the authors of studies instead of hiring someone to interpret their work, which is a pet peeve of Dr. Brad Schoenfeld. Uh, we don't go for the low-hanging fruit.

[00:57:14] We have the authors on, they tell us really what is important and the research and. That takes time and takes effort, takes a team of people and who pays for that? Well, people like Juba cell essay dot SHR network.biz/live better. 20% off. Use the code SHR, show them some love. They support the show. So we need to support them as well.

[00:57:36] Uh, Aaron, I want to thank you. It's always fascinating to have you on the show.

[00:57:40] Erin Sharoni: [00:57:40] Oh, likewise. Thank you so much. I really appreciate it. And thanks for your support of Juba cell and anyone listening. If you do. Uh, try us, which I hope that you will. Um, you can always follow us on Instagram at, to cell and please get in touch with us and let us know.

[00:57:53] Um, what do you like, is there anything you don't like, what do you want to see? How do you feel? Um, ask us any questions. We really thrive on [00:58:00] that customer feedback. So that's, that's one thing that I would, I would, uh, I would ask from anyone who does end up trying it, trying our

[00:58:07] Carl Lanore: [00:58:07] product. Thanks for being here today.

[00:58:08] We'll see you again soon. Okay. Thanks so much take care. Uh, we're going to take a quick commercial break. And when we come back, I want to tell you about some other shows. Did you know that lane Norton's going to be on that? The show? Um, a lot of people don't know this, but. Super human radio is the first podcast Layne Norton ever did before he even got his doctorate.

[00:58:27] Uh, when he was up at the university of Illinois, working at, uh, Dr. Don, uh, layman's lab on, uh, the different types of protein and protein, synthetic response to training. And he's coming back on the show, he's looking forward to it. We're going to talk about. Sensible dieting. You know, this is the time of year where people try these extreme diets, uh, and they fail because they can't stick with them.

[00:58:49] You know, Laine walks the walk. He's an amazing bodybuilder. He's a super strong, I mean, I think he just dead lifted 727 or [00:59:00] 747 pounds. At a bodyweight of like 230 pounds. And he's recovering from multiple spine problems that happened to him a while ago and people counted him out and he came back and the guy is very sensible when it comes to talking about diet.

[00:59:18] So he's on this week, but stay tuned. I want to tell you about all the shows that are going on this week. We'll be right back. Oh, and here's a tip. The secret word is in the next break. So listen. Oh, yeah. Oh yeah. Oh yeah.

[00:59:40] what'd you think I was doing? I'm playing with my media on this thing is great. I take it with me. I use it on the back of my neck. I use it in my lumbar spine and, uh, we're giving one away. Why not? How you can enter it to win-win. There you go. Go to SHR network.biz/free media and enter to win. [01:00:00] This thing is great.

[01:00:01] It really is. I take it to the office now, just because. I find that from sitting for a few hours a day, if I drop it right down here and my lumbar back lumbar spine right there, and then I kinda really sent to it. I feel it through my whole spine, I feel to my whole back. And it has a heat, uh, setting too.

[01:00:21] So you can make it warm and it's got like three different speeds. That's one that's two. Oh yeah. That'll bring you home. That's three. So check it out, go to SHR network.biz/free media and enter to win your free media or today. So tomorrow is a Tuesday, which means that we have the blueprint power hour, but the second hour of tomorrow show is fascinating.

[01:00:49] If you or anyone, you know, has ever had brain cancer, you want to listen to the second half of tomorrow show because there's new research that shows that. Brain [01:01:00] cancer may have been started by a brain injury. And if you remember the show we did last week with the Jerry and the grotto about nothing hidden, um, his daughter, Bella, who ended up committing suicide.

[01:01:14] Um, she had three different brain injuries. Uh, one of them was caused at birth. So paying attention to bumping your head is really important. Because that bump than the damage, the, uh, of the trauma to the brain. And especially everybody's got TBI today, football players, your son played hockey. He got banged around a few times when he was young.

[01:01:40] This may be a precursor for the onset of tumors in the brain. So about that during the second hour, I've got lots of questions for the scientists. And then of course, Wednesday, we're joined by Layne Norton. Uh, that's going to be a great show. Hopefully you'll make that one. And of course, if you can't make it live, we'd love to fit people that make it live.

[01:02:00] [01:02:00] Cause then you can participate. You can ask questions if you want to. I don't open questions up every show, but I'll definitely open questions up for Dr. Lane Norton show because I know so many people are crazy about him. He has such a huge following, but this is a, these are going to be some good interviews tomorrow and Wednesday.

[01:02:17] We're still working on a show, uh, for Friday, I think I'm going to be off on Thursday. I've got lots of other work to, to get done with. Um, but if you can't tune in live, please. Uh, listen to the podcast or watch the video on YouTube. And of course always share the shows, help me out and share the shows whenever possible.

[01:02:39] I that's it for today. Uh, hope you enjoyed today's show. We'll see you tomorrow with more superhuman radio. [01:03:00] .