Dr. Carl Paige, MD

A two-week regimen once a year with this one of these three peptides have been claimed to reverse observable and biological aging in rodents and humans by a Russian scientist. Do they work?

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Download Episode SHR # 2329

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Show Notes:

[2:35] Dr. Paige’s initial thoughts on pinealon.

• The penial gland is like the tiny control center that steers the ship.

[4:57] Melatonin for anti-aging.

• It can repair a damaged blood-brain barrier.
• Potent antioxidant.

[6:03] Epitalon

• Normalization of circadian rhythms and adrenal fatigue.

[6:50~7:00] “ You can take all of the fancy peptides you want, but if you aren’t getting enough sleep…”

• You will not notice much from these peptides.

[9:45] Anisimov et al. study.

• 12% of the longest lived rodents lived longer than what would be considered a long life.
• Epitalon seemed to lengthen their telomeres.
• Cancer and damaged DNA markers seemed to be suppressed.
• This is remarkable due to the fact that longer life is usually correlated with higher rates of cancer and DNA damage.

[12:35] Epitalon dosing.

• Most people use 10 units nightly on an ongoing basis. This results in increased delta- wave sleep (1-3 hz)
• Doesn’t necessarily sedate you.

[16:48] Could it be taken intra-nasally?

• It should be able to from a size perspective.

[18:00] Blood marker expectations

• Glucose metabolism should improve.
• Testosterone levels could improve.

[23:16] DSIP

• Deep sleep inducing peptide.
• It is a nanopeptide.
• Used for withdrawals and circadian rhythms.
• Augments LH production.
• Chronic pain patients tend to benefit the most from this peptide.
• It is a better alternative to benzos.
• Works on the GABA receptor

[26:15] When to take?

• When you are home from work.
• Dosage is adjustable ~ 100mcg.
• Should work synergistically with melatonin, but, ideally, we should increase our natural production of melatonin with this peptide.

[32:26] BPC 157 and TB4 update from listener.

• Don’t ignore tendonitis. It could become tendonosis.

[38:17] Pinealon

• Has a big following from the nootropic crowd.
• Has shown positive results in chronic morbidity brain syndrome patients.
• Protected the offspring of rats with MTHFR syndrome.

[40:12] “There’s almost some pompousity…… - [40:36]

[41:34] Pinealon dosing.

• Dr. Paige doesn’t prescribe it much.
• Potential use in those with major depression disorder that is caused by inflammation of the brain.
• Probably not the strongest nootropic, but it is better for brain inflammation, TBI, brain hypoxia, and methylation defects.

[44:40] Side effects?

• No known LD-50 yet.
• No known drug interactions yet.
• The body can break down excess of these peptides more easily than a drug.
• Taylormade pharmacy synthesizes these peptides in a clean environment.
• No need for black market purchases anymore.
• peptidesociety.org
• Physicians can prescribe now.

[48:00] BPC/ TB4 and surgery.

• BPC 300-500mcg 2x/day.
• TB4 2 mg every 3^rdday.
• Could also dose 2-3 days ahead of surgery while loading up on collagen.
• Carl used 2 IU’s of GH with his foot surgery along with BPC 157.
• BPC and TB4 can be drawn into the same syringe.

[52:08] peptides for genetically high cholesterol?

• Modify your diet.
• Ipamorelin, CJC, GHRP-6
• Carl: No such thing as genetically high cholesterol. It is a lifestyle/ environment thing.
• Cut out the carbs for 2-3 months.
• Cholesterol will initially go up, but then it will go back down.
• Possibly linked to inflammation in the body?

[55:35] Gastric bypass surgery fallacies.

• Why not try the things that are required for its long term success first?

[56:30]Is there anything like Benzo’s for anxiety?

• Selank
• Theanine, Glycine.
• Proper sleep hygiene.

[57:46} sources for collagen support before surgery

-Great lakes brand.

- Dr. Seeds

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Show Transcript

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[00:00:00] Welcome back to another episode of superhuman radio Today's Show is becoming a quick favorite of the audience. And that is the pep talk with. Dr. Carl page and will be joining me in just a moment. We're going to talk about a couple peptides that have been touted as having the ability to reverse observable and biological aging and.

[00:00:54] Because the research comes from Russia and from one specific group, it is right [00:01:00] not being taken seriously. In fact, dr. Russell Rider that let me bring dr. Page on. Let me do this whole I'm sorry. I'm being so selfish. How you dug the page? I'm doing fun. So as I was saying a better guy, I've had dr.

[00:01:14] Russell Rider on my show probably six or seven times in the past 13 years and I don't know if you're familiar with him, but he is known as The Godfather of the pineal gland. He has authored over 800 papers. He has authored and co-authored about three dozen books many of them University books and he has studied the pineal gland Glendon its primary hormone melatonin, but when I told.

[00:01:38] About the research out of Russia. He scoffed at it. He said it's never been reproduced. It's nonsense and I've written a rebuttal paper about that Bubba and it's almost like I got this sense from him that there was an emotional tide of foot with that research because we know that there was there was a study.

[00:01:59] And then you're probably [00:02:00] familiar with where they actually peen elect demised rodents and they took the penal pineal gland of the old rats and put it in the new rats and vice versa and the old rat started to take on all the attributes of the young rats and the young rats started acting like they were really old.

[00:02:16] You remember that research you remember that? Yeah Cordia work from but I do recognize it. And so, you know, I wanted to believe that penal on an epic towel on could actually have this kind of age-reversing effect and no but no one here in the United States wanted to believe the Russians. So first of all, when did you first learn about these two peptides and what were your initial thoughts when you when you learned about.

[00:02:39] Well initial thoughts were that it's the pineal gland was just sort of this mystery gland forever. It just made you know, melatonin was always thought that it did and it clearly has other functions in the body. It also just from a structural standpoint a location standpoint being at the epiphysis.

[00:02:56] She notices Latin name. That's the [00:03:00] point of when you look at the Primitive brain. It's there right at the top. There's a single structure that you know normally is a very important structure. You got one heart, you know, it doesn't have two sides. It's the got blood supply on the level of the the kidneys, you know, so very vascular blood supply so doesn't have really the same blood brain barrier that the rest of the brain has so it's intimately designed to be in communication with the rest of the body and then provide information and feedback to the brain.

[00:03:31] So this one you just look at it from Indiana. Structure it's quite unique and and the way it's plumbed essentially means it must be pretty important. Well, and when you if you compare it to a couple of the structures that we have familiarity with kind of analogous to when you look at the blimp, it's this huge balloon of a device, but at the very very bottom there's this little.

[00:03:54] You know appendix hanging at the bottom of it that is actually doing all the thinking and driving [00:04:00] and the same is true if you look at this. Ship Enterprise, you know, it's this thing all the way out over there by itself that's driving this massive ship and when you look at the pineal gland dangling there like berries, you know hidden in the end the copy of a tree you think to yourself.

[00:04:16] Wow, that's like the control center that's driving the brain. It's the brains brain is what it is. Yeah regulatory was in actually RI lies, you know, it's got autonomic nervous system evasion parasympathetic and sympathetic. It's a highly vascular. Um, you know in the world of the body and it's a single organ is preserved across species through many Millennia, you know that are you know, anime anime alien species will have the pineal gland so like mitochondria, you know, we've all got mitochondria.

[00:04:47] They've been hanging around for a long time. So I got that about it that just from its Essence standpoint make you think that it must be more important than we figured out yet. Right. So we all know about melatonin and melatonin at [00:05:00] every day researchers published. That shows more evidence that melatonin maybe possibly the least expensive antiaging product.

[00:05:14] You could use in your life. I mean, it's just every every time you turn around you look at the research coming forth about melatonin. It's now a recent study showed that it can actually repair damaged blood brain barrier. Barrier. Yeah, like that's that to me. That's like okay I okay. You know, this is a really smart molecule this molecule is really important.

[00:05:34] And when you look at the average American they impair their own melatonin production with poor sleep hygiene and staying up at night and eating too late and so on and so forth. So it makes a lot of sense that there's a lot of these problems going on, but why exposures and suppressing it? It's also one of the instant very very potent antioxidant effect.

[00:05:52] Yeah. That's yeah. This is one of the best actually. Yes. So now let's move forward and I even have a little [00:06:00] title set up. So first we're going to talk about if you tell Lon Epi Talon people have heard about every Talent it's available on a lot of the peptide research websites and stuff like that.

[00:06:11] I but I don't really think I think people think they know what it's supposed to do. Because of like the telephone well, I think it does this and by the time it gets over there, it also cures cancer, you know, but I don't think people really know what it's designed to do. So from a therapeutic and practitioners standpoint.

[00:06:30] What would you use at be Talent? The biggest thing would be normalization of sleep, you know getting patients. You maybe have this concept you might be fair with of adrenal fatigue, you know, normalizing that getting their circadian rhythms back into where they have deep sleep and get recovery time.

[00:06:51] So a lot of the if you sleep deeper which it will cause you know, melatonin, Then you're going to recover faster. If you're may do a [00:07:00] lot of other fancy nutritional exercise and peptide things. But if you're not getting that deep restorative sleep which Delta Sleep can be augmented by a potato on the you won't get full recovery.

[00:07:11] So on a level it it's going to help with that and you know, so that's a common problem we deal with in the office is chronic fatigue, you know, the adrenal exhaustion concept, which it's probably over played from a dream. Standpoint but prices during right, right. They do get chronically fatigued and that's just the way to have that so how so how is not the original research that came out of Russia indicated a fairly high dose.

[00:07:42] Now, I'm going from memory. It was like something like 10 milligrams a day for for 10 days or no, no for twenty to ten days five or no 20 milligrams a day for 10 days 10. They for 20 days once a year. Am I [00:08:00] close that that was the original look exposed finger, very large dose is really above and beyond what the average person's going to be able to afford, you know on a just a home use type basis.

[00:08:10] I'm not sure that you need that much but you know, they must have had access to a lot of it to achieve that you know, dr. Comments and comments on I believe his shoes researcher referring to and go course, you know, the what you mentioned earlier a lot of the Russian research at least kind of gets.

[00:08:26] Downplayed by some of the American scientists, but we read the data. It actually looks very elegant. They did, you know, they did their research correctly and you know, they maybe it's not been reproduced but I'm not sure who's trying to reproduce. So that's the other thing who is really looking for gerontological breakthroughs not big Pharma big Pharma doesn't want people to live healthier longer lives.

[00:08:51] They want them to be dependent on these pharmaceutical drugs to get them to assure. Wife so really no no one is researching it. No one's researching it [00:09:00] right with any with any sincerity. Right? And Age Management is really I got a nice thing from our local Society the other day medical ID on the Age Management and it basically was you know, managing the decline or if you've been dumped, you know persons in this situation, obviously, they need as much assistance as they can but it's really managing the person who's already essentially failed from a biophysical standpoint.

[00:09:24] That's just concept. Management's not really. What can we do to prolong a function, you know cheap quality of life. Those are not things that are at least high on the research and like you said the big Pharma doesn't necessarily want these to get better because then you'd have to stop taking the standard prescription medicines that I we don't work for it.

[00:09:43] So one study that I read that was Addison move a tile. He did a study with two groups of 50 rodents. One got saline what one got a paper towel on but they got them for the duration of their lives. [00:10:00] And and and what they noticed was that the 12% of the rodents that lived the longest were on the no 12% of the longest-lived rodents live beyond what was considered an average life span for a rodent.

[00:10:20] So not only did they all the. Sonnet live longer but some of them lived longer than had been predicted for their you know for their little group of patients. Yeah, and so the unique things well, the other thing that I thought was really interesting was that it had a direct effect on DNA and telomerase it actually lengthen telomeres and and you know, so everybody is out there taking bushwhack wheat and all this other stuff to try to lengthen telomeres today.

[00:10:49] And it looks like Epi towel on does it really successfully. And they and the study they talked about how the the length of telomeres was more than just preserved. It was [00:11:00] increased from the start of the event study. Well, and you know in the in the longevity studies particularly with the in the animal models not only did the animals live longer.

[00:11:11] They. Like a lot of things as you live longer, you're more likely to develop cancer with its functional DNA transcription. So the cancer actually decreased in the at the arms. Yeah, and so did and so did evidence of damage DNA. I'm looking for some other there was another line that I tried to keep out to read.

[00:11:35] But it also it also protected chromosomes and and DNA and and actually suppress the development of tumor cells in the bone and the bone marrow and the bone marrow, right? That's why I was looking for a reason. So you're talking about something that happens to increase lifespan, but also doesn't increase the likelihood of developing cancers, which is [00:12:00] associated.

[00:12:00] Did with increased lifespan, correct? Correct, which says what are your unique combination of attributes? It has is to prolong life span, but not for long your or not promote the development of cancer. So driving an old car and never fixing anything it actually by helping those telomeres cap off and and function properly with the upregulation of with its Allure erase the protects the chromosomes so they can maintain their integrity and divide the way they're.

[00:12:29] Soon transfer information Downstream appropriately what so what kind of dosing are people using of Epi towel on the ones that are using this peptide to try to help improve outcomes as they age, you know, the dose is the large doses that you saw in the conductor common signs research is really not practical for most people to use at home 10 10 units on a nightly basis.

[00:12:57] Ongoing certainly promotes deep [00:13:00] sleep, you know people that use their watches and monitor whether they had deeper not you were right right Rings or rings. You'll notice an improvement in deep Sleep with the induction of our introduction of Epi towel on it night and it's not a sleep that is drugged at all.

[00:13:18] It's just taking you down to Natural deep sleep you'll dream and then get into Delta wave sleep, which is your recovery phase and that. Be used on going, you know, it's in as far as the human trials really the big human trials really worthy not big. But for they use it in the cardiac patients in Russia, you know, they had a group of cardiovascular patients.

[00:13:38] Really. I'm yeah, they were considered the basically the way I read this study was that these were patients who are already in pretty bad shape. It was found to be Gerald protective when they. It's clear, you know decrease the incidence of cancer. They noticed Improvement in cardiovascular function in [00:14:00] these 30 had known significant cardiovascular disease over time preserved kidney function over time with the use of debit a Lon so the functional life span of these patients was.

[00:14:14] Compared to the cohort who did not receive that the towel on so there is some human studies done and it's not been take outside the Eastern Bloc yet and it's kind of when I'm reading through these Russian studies. I'm a little jealous their anti-aging Community appears. Yeah from a point where robust and what we have in this country, but you know, they don't have a pharmaceutical agenda.

[00:14:35] Right, right that plays a big role in that. I mean, I really don't know what you're you know, they're obscure they've got State funding but they're basically allowing The Sciences to work in the areas where they have an interest in and develop science truly. Not just you know, what's the next, you know, you know purple pill or whatever that you think of so the bottom line is 10 units before bed like right at bedtime because I know we're [00:15:00] going to talk about dsrip later dsrip.

[00:15:01] You have to take like an hour before bed. Is this why you need to get rid of them from you know, I wouldn't you you're not going to stay. I mean I use a talent at night. I don't sometimes I'll take it early and ended up staying up watching a movie a little longer than I would like to do and it doesn't make me feel sedated.

[00:15:19] But when I juice I go to deeper sleep it really? Okay. I've not noticed personally that it's been a sedative per se. Oh can it certainly the unfortunate once or twice have been exposed to ambient in the hospital? It's nothing like that at all. For medicine. Yeah, I don't want that. So so ten units anytime within an hour before bed you're fine and that's going to improve the it's going to improve sleep architecture, but it's also doing some other magical things that magical things as mechanism of action, you know is that's what's not been elucidated to any great detail that I really think ought to be, you know, this thing tetrapeptide, you know, it's very small if you know [00:16:00] clearly crosses the blood-brain barrier work through whatever.

[00:16:03] Kazuma does to have the habits affect in the data on it at least in animal studies in the small amounts of human studies that we have are very encouraging and guess when you look at it being a an extract of a larger pool of a patalamon peptides, you know, so that's not the it's a it's Church create the effect of what you would get with that patalamon or the large pool of similar peptides.

[00:16:29] They made a Potala on is the single tetrapeptide, but it. Those have that sort of preserved sequence. You see in a lot of very bio potent amino acids, you know, so as you structure, yes, so since it's such a small peptide its idea, it could be delivered intranasally, is that how people should be using it if they'll taking it for sleep or should they do an injection?

[00:16:54] It's gotta be weird country, it's got to be under under 500 Dalton if it's [00:17:00] detected a small for the size to you but you know from a science standpoint, it's should be able to be delivered that way it'll just come down to stability in solution and things like that. You know, how long can you keep that bottle spray and still maintain potency of your time right now that makes a good point wouldn't take much to break it down either.

[00:17:19] And and what about I'm a I've been threatening for. Years now of trying the 10 the 10 to the 10 milligrams a day 10 units a day 10 units a day. I'm sorry 10 units a day for 20 days. I've actually thought about I actually could get the Epi towel on I know it's real and I'm just thinking to myself I would have to have some sort of Baseline blood work done or something that looks at some sort of Hallmarks of aging and then look at them after doing.

[00:17:53] 20-day round of it and see what changes sure, you know biomarkers at least [00:18:00] in the studies. He did long-term you notice to improve glucose metabolism, you know, so that's the Melatonin levels obviously would respond significantly to that and being so simple things you can monitor. As you get deeper sleep, you would expect you know improved LH release improved just naturally if you're you know Soul cycling on your own to produce natural T levels.

[00:18:21] So a lot of your Downstream hormones that are triggered during the night will respond to the that as well. Yeah. No, absolutely. So look we're going to do we're going to take a quick commercial break when we come back. Let's talk. You want to talk about pain alone or vsip first you tell me. You pick all those.

[00:18:41] Okay, I'll surprise you audience on the other side if you want to work with. Dr. Carl page, you can look on the internet for the medical Transformation Center. That's the website medical medical transformation center.com. We already have people in the audience saying that they're reaching out to dr.

[00:18:56] Page and they love the guy. He's hard not to [00:19:00] love. I'll tell you that right now. So let's do this. Let's take one quick commercial break and we'll be right back. Welcome back. I gotta give a shout out to oh Tom segond. Is in Calcutta and helping me grow the reach of super human radio. I hope I pronounced your name, right?

[00:19:19] I'm sorry. If I didn't knew Tommy can you can tell me later anyway, so now we're going to talk about another peptide. And again, these are injectable peptides, but I have a funny feeling because that they're three and four peptide amino acid sequences that they're probably small enough to deliver in alternative methods.

[00:19:38] The next one we're going to talk about is. Type e this is one that I've used and I can't say that I can't say that I really noticed a lot from it. But some people claim that they notice a lot from it. So what is DS IP stand for dr. Page? Um, you know from a practical standpoint deep sleep [00:20:00] inducing peptide, you know, it's got a fancier.

[00:20:01] That was it. I mean the guys in the guise of the lab will like let's just make this one easy on everybody. Yeah when his burger and I can remember that so, you know, what's a nano peptide so not not as little bigger than the you know, the Epitaph Lon, okay. You know used a lot really in the peptide world for drug withdrawal alcohol withdrawal re-establishing circadian rhythm sleep abnormalities.

[00:20:26] Henna is found to have an effect at all levels of the HPA axis to to help re-establish normal function can be used primarily for from a hypogonadism standpoint to augment LH production, which may be a fact as well as just you know in. You can see deeper sleep to allow release of LAX. So that testosterone will recover the patients.

[00:20:53] I've had with it that it had the most tremendous response have been those chronic pain patients. Just you know, they hurt the [00:21:00] can't sleep. There's always some comorbid conditions that have impacted sleep there. They. They sleep during the day don't sleep at night, you know, someone were trying to get them off of chronic opioids.

[00:21:11] You know, I don't prescribe those that many patients come in here that are on those and we try to help them get off of them or just from a withdrawal standpoint when a person has decided to stop drinking or stop using those. What about what about benzodiazepines people get addicted to be a benzos to sleep at night it and it actually causes something called REM sleep disorder where they actually out act out their dreams.

[00:21:34] Do you think dsrip would be good to help them? Re-establish a good sleep patterns? Yeah, definitely useful in that standpoint. It does work on the Gaba axis. That's where the benzos are going to have. Their direct effect is working on Gaba system. So it does have a significant effect there, you know the chronic shift disorders.

[00:21:53] I might see. You know people that fly across several time zones from a career standpoint [00:22:00] and have trouble sleeping at night when they come back home or people that have been on third shift for forever. And now trying to go back to the first shift. It's very useful in those areas in this some chronic insomniacs that literally never sleep properly never have slept property, but don't have any clear out the physiologic condition that we've been able to determine it made more of a chronic brain injury or dysfunction.

[00:22:24] Computers are going to sleep. And you take this about an hour before bed right traditionally, you would use the first dose to sort of discern an effect. Some people take it in are so before bed and they fall asleep out have some patients. They take it at lunch and then they feel sleepy at night.

[00:22:42] So, you know, it's really individualized. So you do sort of probably want to plan on that first dose not knowing how it might impact you so what would it be wiser to take it once you're home from work? Like maybe you have to get her to see how fast you start to take it over the weekend, see how you [00:23:00] respond the first time and then you can use it, you know seven out of seven days and then they were off over time.

[00:23:05] Once you've developed a normal pattern sleep some people if they have chronic current really permanent sleep abnormalities. They may just want to stay on it to for Sleep maintenance. Yeah. I was told to think of an hour. Or sleep. I didn't notice any of the any changes in sleep architecture from a but maybe I needed to take it earlier in the day.

[00:23:22] And so I'll give it a try. Did you notice anything when you're ordering or did you monitor that I didn't have it back then? I have it now now I wear this and I wear something else cool to sleep on. Which is actually it measures blood Ox. It measures activity. It measures a hi. It measures description your mini sleep study.

[00:23:43] Yeah it is and actually I recommend two doctors that they have four or five of these in their office because if you have a patient you noticed, you know fingernail clubbing they talk about being exhausted all the time before you set them up for a sleep study. So [00:24:00] he go home and sleep with this ring two nights in a row.

[00:24:02] He put it on like this go to sleep in the morning. Put it in the charger the next I put it on again. And then the next morning drop it off here at the office and you can look it'll give you a chai. You'll see them you'll see them pulse ox is dropping in the middle of the night when they are gasping for air.

[00:24:16] I mean you like. Oh you need a CPAP. That's your penis. Yeah, for sure. Yeah. Yeah, they're great. They're great. But I also record so I hear myself snoring. I have a recorder that's part of a sleep app that measures. Hmm activity in the bed moving and it also has a Vox feature voice operated transmit these me but what Vox really is is this turns the mic on and would record me snoring so I know oh my God last night.

[00:24:47] I snored four four four four minutes between I mean four minutes is a long time for me. Usually when I do snore I snore for a minute or two and I must readjust and it goes and it stops. Yeah, your body are usually flip around at this specially if you're not got, you know, [00:25:00] anything impairing your.

[00:25:01] This is you go to bed. So the dsrip you would you have to figure out your own personal time to take it where you notice that you sleep better after you've taken it at that time. Number one. What is it like a hundred units that you take or hundred? What's the dose really kind of adjust for it's going to be traditional dose is 100 micrograms, you know.

[00:25:22] From 10 to 20 units, I think okay. There you go. But that I guess I mean micrograms hundred micrograms. So you take a hundred micrograms of that at the experimental our probably the first time you use it use it sometime after work when you want your home and see if you sleep better than and then you could creep closer towards bedtime maybe and see if it improves the depth of sleep right right side trade one or the other and if you've got the ability to have a wearable or something to give you some feedback on it.

[00:25:48] That's. It's very good, you know with a lot of patience if you just look at depression, you know is a diagnosis or they will often have sleep disturbances, you know, so if you can get them to sleep better [00:26:00] then many times Moot and cruise so we'll use it in that scenario if they've been on multiple medicines not responded.

[00:26:08] You know, I don't prescribe the traditional medicines for that in the practice. I'm in now. So we're often trying to augment the effect of traditional medicines or maybe help them get off of those medicines that's usually most patients goals now, could you use these two peptides we've discussed so far in conjunction with your bedtime melatonin dose.

[00:26:28] You know stacking them is I don't think you're going to find a lot of wood published research on that is going to be mostly anecdotal. They should work in conjunction quite well, but if you're going to with Epi Talent augment melatonin release, you know, ideally we would want your pituitary to be releasing in making its own melatonin and I just like ìwell I but the thing I'm concerned about personally is that I've taken melatonin every night of my life for 20 years now someday.

[00:26:58] Then that that's not totally true. There are [00:27:00] nights where I forgot it and I didn't sleep great, but I went to sleep. So do you think that my melatonin production is impaired to some degree or is it just the rib necessity of my pineal gland having to wake up and do some work at night? you know, there's maybe a couple of factors, you know, if you're if you're trying to stimulate release of melatonin and you've been to over releasing it or overdosing with it, and you may have down-regulation of the.

[00:27:27] We did receive an impact from the downstream. So your nap just release that might be triggered with Eva Talent may be blunted a little bit. If you've been taking 50 milligrams at night. No, I'm supposed to ever take his 10. That's what I use again because I'm fine. Yeah, it's not unreasonable debts is so from a theoretical standpoint.

[00:27:46] That would be an issue is how much have you been taking and had you? Yeah, but you know to its aperture is also not having to do his job because you're supplementing right now at least [00:28:00] yeah, is it going to should over time though? If you had it in something like at the Talon in backed off your melatonin does to be able to if it hadn't been calcified and was totally totally dead, you know, sometimes the pituitary will literally just sort of shut down to become a.

[00:28:15] Um phosphate module, which is not that uncommon you'll see it common on dental X-rays or other MRIs that you get a pituitary is calcified. You know, it's yeah probably glows white like a little Cherry. Yeah, and here's some suspicions, you know, I don't want to get too much into that one, but really the fluoride and things, you know, does it have any impact on Kappa going?

[00:28:35] Yeah. Okay. So so basically a hundred micrograms some time before bed experiment with the time. I want to bring one question up for we switch gears and we come back and. Bob Pina Lon Dave Hart and it said he's using the bpc 157 and the TB 500 for an elbow tendon tear that happened last July. He said this stuff is life saving every every time somebody uses especially [00:29:00] bpc 157 because it's one of those peptides that you feel it working.

[00:29:05] Not while it's working but the mitigation of pain and going wow, like this pain has been bugging me for six months. Now this tennis elbow you name. And like three days later, it's just gone. Could that have been it like kid that right? Yeah. That was it. Yeah, we just weird like that, you know, and that's a great combo, you know TV for and be pc 1 5 6 7 or especially with the collagen poor.

[00:29:29] Are you going to college and Crossing it a couple different ways with that and Recovery certainly enhanced with that. He looks like he's okay and from a from a growth hormones testosterone levels. So it's already got a base of you know that on board. So yeah and anytime the Overture. Laughter get hurt just accidental injury.

[00:29:47] It's going to be usually a tendon insertion or you know, chronic tendinitis impact and those are wonderful combos for that and don't ignore tendonitis because that's why I detached my tricep. I ignored [00:30:00] tendonitis and kept raining all just lighten up. I'll I'll study Kinesiology. I'll change the angles, but I'll keep training.

[00:30:06] And so when you aggregate aggravate tendonitis long enough becomes. And tendinosis is the fraying of the tendon literally starts to just shred in tooth, like like a warm cloth. It starts to shred into threads. And once they those are all separated. It doesn't have the combined strength that hat and snap.

[00:30:28] Yeah, the structural Integrity is gone last isset. He's gone. The tendinitis is really does microscopic cheering and cheering like you're describing more in a macro level, but the tendinitis is if you were to, you know, split the tendon and look at it you would see microfibrils sworn. Yeah, so that's another path.

[00:30:46] So we're going to take a break and when we come back, we're going to talk about penal on with. Dr. Carl page. Stay tuned. We'll be right back. Welcome back. To the pep talk [00:31:00] Kirkland. Well lady who does work for the show and there's a friend of mine. He he came up with the name for the pep talk doc when we gonna do it because we knew that people love to talk about peptides is so.

[00:31:15] We have a couple questions. We're going to get to your Casey Alicia Morrow and James Clark. I promise we will get to your questions. We're going to talk about penal on first just to kind of stay on track. So penal on is another one of these peptides that was studied by the Russians that they claimed could reverse biological aging.

[00:31:33] They used it to study rodent and rodents and it actually has. A big following a amongst the nootropic cognitive enhancement that category of of user out there. There's a this lot of people selling penal on.

[00:31:53] What do you think? What do you? Well, I mean, it's a very small peptide again. Most of the data [00:32:00] comes from the Russians, which is not a bad thing, but it's not widely. If you do a PubMed search on it. It's just as page with mostly Russian, you know product of research products on it. There was one human study that did use it for organic brain syndrome or chronic poly morbidity brain syndrome did show positive results and improve.

[00:32:24] Don't you know from a neuro inflammatory standpoint and from an antioxidant TB? I think this is a good subject for TBI then right? Well, that's kind of what I would think with it. The other one that I noted armed when I reviewed him was really that they in in a rat model that when they had hyper homocysteine emia, which is really the MTHFR snip that it was protective of the red Offspring in the mothers that had you know in MTHFR defects.

[00:32:52] So did we. Issues you would see from Central Nervous standpoint if they had not been [00:33:00] supplemented with activated folate. Wow. Wow, that's amazing. It really is. I mean, it's pretty neat stuff. It would be you know, I'd like to see more data on that and then and then and there lies the problem, right?

[00:33:12] So first of all, for some reason here in the United States, we turn on nose up on anybody else's research. There's almost an attitude of pomposity amongst. A cloth a doctor because it's like well that research came from this other country like somehow that would be that would discount its value.

[00:33:31] But then on the other hand you have the Russians will working hard on creating disinformation in every sphere that they could influence and this could be just another one of them. We just don't know but what but what would they gain out of lying about this? What would they gain out of it? You know how most of the stuff was published the especially with some of the small peptides, you know?

[00:33:53] We're leaving broke down the curtain, you know, at least they were doing the research on it. But themselves they would do it for themselves. They weren't doing it like oh we're gonna give this to the United States [00:34:00] and confuse the heck out of them, you know, they didn't want to give it to the grass leaves and for the rest of the people here, so just by 7, but just by virtue of the environment that this this data was created.

[00:34:12] We know that they're not going to be chasing and running in circles at nothing. They want their performance enhancement for their people. Yeah. I'm sure that stuff goes on. I'm a little you know, Sure, it goes on on this side of the pond. So so I'm not going to you know, yeah. No absolutely. It's a race in terms of corrupted by money and buy the you know, the big the big Pharma side of things is corrupted some of the data that gets published.

[00:34:37] So these are for yeah, they benefit the most robust distrusting everybody else's research by the way, just just for the record, right? So with penal on what kind of dosing we talked about. How is this administered? Is it a nighttime thing also or you know, I'm going to. That I don't personally prescribe this one a lot because they label out of people.

[00:34:56] I don't have access really for my you know, certified [00:35:00] producers to high-quality injectable versions of that at this point the like to it seems like it would be relatively simple to manufacture because it's being the very small pets. Well, I'll tell you where they could be a potential use for it.

[00:35:14] So there's a very large percentage of people who have major depressive disorder that this. Depressive disorder arises from inflammation of specific areas of the regions of the brain and that when you get these people on diets that reduce inflammation in general and you remove some of the things from their environment that are causing some of these problems their depression goes away and can be it can be tracked as the information gets less and less and so it seems to me that penal on because of its.

[00:35:52] For anti-inflammatory effects on the brain that are displayed in a lot of the literature that did come from Russia. This may be good a good [00:36:00] alternative for people who are suffering from an inflammation precipitated major depressive disorder. This is this is a shot that can't hurt them and may help them.

[00:36:10] What do you think? Well, I mean any of the neurodegenerative conditions the you know, autism any of the neuroinflammatory narottam you conditions that have an inflammatory component potentially could. Fond of that there doesn't appear to be a lot of downsides, you know to based on when you look at its structure and how it functions.

[00:36:28] I think as a straight note rope, you know being something that you might take before you go take your finals or something. It's probably not going to be its strong point. You know, it's just far as immediate impact or make you just suddenly become Super Genius, you know, that may not be the most appropriate way to think of it.

[00:36:45] But like you said TBI any other post-infectious neuroinflammatory. As toxic mediated, you know hypoxic mediated clearly. There was hypoxia Associated data on it. [00:37:00] Oh, yes, I saw that so so so when what that study was indicating that the brain was without oxygen for a period of time and attacked this help mitigate some of the collateral damage right here.

[00:37:10] This guy try. Yeah. I saw that one. Yes, we can imagine all of you know close to Drowning post, you know stroke, even, you know, it's a lack of blood supply. Right, right. Strangulation injuries, there's all sorts of, you know, I think the one with the because I did Pediatrics as well for a while the methylation defects in you know kids that have that and then unfortunately have hypoxia birth, you know, if you need to, you know, it's very hard to get these type of studies done in this country.

[00:37:38] So thank God that Russia's able to do some of this. Yeah. I got it because they were doing it for their own people. They weren't doing it for profit, right? Okay. So now of course people always say to me of the three peptides we talked about this afternoon. But what are the side effects because they're so used to Pharmaceuticals where it's a it's a it's a risk versus [00:38:00] reward scenario like yeah, you're going to get that but we're going to stop this from happening.

[00:38:04] What are the side effects of taking these doses? Are there any known ld50s on any of these peptides? You know, hope you're still with making hear me. Yeah, I can hear you. I can hear you. I hear you follow. Okay? Yeah for the for the for the most. That's really what's special about peptides is you know, they are literally just sequences of amino acids.

[00:38:25] Your body will break them down into constituent amino acids and then re utilize them. So not really any any known ld50 to these things. Right? Right, but they don't drug interact with other medicines because of the same reason they're not sip enzyme degraded and have to be urinated or passed out through the GI tract brightness.

[00:38:48] It's their special that way and so for those of you watching a show going. Yeah, but how do we know this stuff is good. We buying it from a research chemical. We're not suggesting that people buy [00:39:00] things from research chemical and peptide manufacturers. If you have one that you do business with the doc will be back in a minute.

[00:39:05] He got disconnected disconnected. If you have one that you do business with that you trust and you think they have good stuff. That's fine. But you don't have to go Black Market on this stuff anymore. I'm getting it back in here doc. You don't. The go Black Market on this stuff anymore because there is a there is a pharmacy in Nicholasville Kentucky called tailor-made compounding pharmacy and your doctor can order these peptides and prescribe them.

[00:39:34] And they make them write a tailor-made. I've seen their amino acid sequences. I've seen how they they don't. This is not recombinant method then I use an E coli and feeding it amino acids and it poops out a strand and that's you know, what they are doing is that actually synthesizing these peptides in a clean environment?

[00:39:52] And they are pure and and so your doctor can actually get in touch with tailor-made and they can fill [00:40:00] prescriptions that your doctor can write for you. Now if your doctor says to you, I don't know anything about peptides. I can't prescribe peptides for you because I don't know anything about them.

[00:40:10] Well, then you tell your doctor to go to peptide peptide society-dot- org, and that is the international peptide society's website. And I we don't see a doc. I don't know what's going on. We lost the doc. I'm going to try I need you to disconnect one more time and try to reconnect. Anyway, I may have to carry the rest of the show and it won't be a problem if I do so don't worry about that.

[00:40:38] But anyway, your doctor can prescribe these peptides for you. That's the bottom line. You don't have to go black market. This isn't this isn't Dark Side stuff we're talking about. These peptides are available through Physicians today your physician just probably doesn't know that your physician doesn't know that they can be trained by International peptide society and start prescribing these peptides for you.

[00:40:59] We're [00:41:00] going to go through these questions. This is what I want to do anyway, so. Casey Alicia Morrow. I'm assuming that's a combo account says what dose of be PC and TB 500 would be beneficial for recovery from umbilical hernia surgery. And how long would you want to use them? So this is true of any surgery not just the type of surgery.

[00:41:23] You're identifying here. The the bpc 157 should be used anywhere from 300 micrograms to 500. Gramps twice a day for Recovery surgery and thymosin beta for you should use if you if you can afford to use two milligrams every third day. You will probably find well. I'm going to let the good doctor weigh in on that too because we have a we have them coming back on.

[00:41:49] Hold on a second and I'll bring I'll bring him up to speed here real quick. So doc. We had a listener asked the question about using bpc [00:42:00] 157 and thymosin beta 4 post. Perjury and what I suggested was 300 micrograms to 500 micrograms of VPC 157 twice a day and TB 500. Maybe if you can afford a two milligrams every third day those two big of those as you think no, that's not inappropriate.

[00:42:18] There's you know, the dosing range is well within that for utilization. Sometimes you might even want to think about if it's an elective surgery sort of preparing the body ahead of time with dosing for you know, two to three days heading into the. Loading up on College and support so that you have even already things in place to augment recovery.

[00:42:40] And their long the duration would really be dependent afterwards afterwards on what the procedure was, you know major procedures muscular procedures in might be two three months, you know, you might need support that you could gradually taper off of look up. So look I had two foot surgeries in one year on my left foot and this second surgery healed in record [00:43:00] time.

[00:43:00] But I use a half a milligram of bpc every day twice a day every day for the first month. And then after that I dropped to a half a milligram one today and I just stopped using it the other day and this was in December so through January and February. I used at least a half a milligram a day. I didn't use TP Thomason beta for I have a prescription for growth hormone.

[00:43:26] I went ahead and had it filled and I used to I use of growth hormone and. For the duration of my recovery, and then I stopped and I can get TB for and NBC15 7 can be compounded in the same same vial as well. So it's a you know, minimize sticks and save a little bit of money on purchasing and too.

[00:43:47] They have stable and that's good that's good to know and and you know, and the other problem we have is even you and I you know off the air were talking about, you know, injections and stuff like that. You know, I would like to be able to draw [00:44:00] format peptides into one syringe and inject them at one time, but I'm being told that because there is the buffer they don't burn them and they lose charges.

[00:44:10] Yeah, you know, the charges are a big thing near proton donators. So when you put bioactive molecules in a sink. We should like that. They start turning into other things by interacting with each other and I've seen it with my own eyes. So I took two I use of growth hormone, which normally is clear when I inject it.

[00:44:28] I took to I use a growth hormone. I took a hundred and twenty five micrograms of g h RP 6 and a hundred micrograms of modified growth factor 1 through 29 and put them in the same syringe and they turned the Milky and I didn't inject it. I just threw it away. Well, you know, that's at least some sort of.

[00:44:46] She'll never get in there. They're going to maybe be paid out of solution and then you know, that's one thing you may not even be able to draw it up. If it does that but the other thing is what what are they turning into? You know, I've got these this [00:45:00] is amino acids that have very targeted effects in the body.

[00:45:03] The sequence is going to change you may be adding things to that sequence. You maybe be deleting things from an amino acid standpoint. It's just not the same not the same chemical at that. Right? Right. Let's go to Dylan gautreaux. He's a. Away here James Clark says are there any peptides that help with genetic high cholesterol?

[00:45:21] I'm gonna have an opinion about this doc. I'm going to let you weigh in first, you know, the first of Hallmark there would be modify your diet which would be appropriate as much as possible exercise. There is a lot of things you can do before you actually medicate cholesterol, and then you would want to know if you had an inflammatory response associated with oculus true.

[00:45:42] It's a lot of people have high lipids and don't show any plaque formation with it. So that would need to be evaluated. But you know, just igf-1 support your CJC 1295 if immoral in is, you know, plea atrophic affects your entire body metabolically and dislike. It may remove some of your other [00:46:00] aging parameters back into the metabolically back in your mid-30s or so.

[00:46:04] It can move lipid panels just my own personal lipid panel LDL particle number dropped quite precipitously once I introduced. I'm growth hormone support failure to obey all the secreted gah-gah rp6 modified epidemic of Maryland all of them. Yeah, they all do that. Yes. Now this is this is my opinion.

[00:46:24] I'm not a doctor. So there's no such thing as genetically high cholesterol you yes, you got your genes from your family, but you also got the foods that you love from your family and you got the way that you eat from your family and while you can't change your genetics. If you could change your outcome by changing your diet don't listen to your doctor when your doctor tells you, I'm sorry, doc.

[00:46:49] I'm sorry. I'm don't listen to your doctor unless he's dr. Karp age when he went could but no but dr. Pedro tell you the same thing. It's not the fat in your [00:47:00] diet. That's causing cholesterol. It's the sugar and the carbs in your diet. If you stop eating the bread the pasta the stuff that they keep telling you is hard healthy.

[00:47:08] That's really not hard healthy. And it's not a conspiracy theory either. Okay, but the bottom line is you cut out the carbs you go to a high protein moderate fat low carb diet. You do it for two or three months your cholesterol may go up a little bit in the beginning but you give it two weeks and your cholesterol will come right down and it will stay down and you won't even need cholesterol meds.

[00:47:31] This this is this idea that. Cholesterol is genetic is the pharmaceutical industry's approach to making you feel like oh, it's not your fault. Don't worry about it. We just give you a pill everything will be okay. No, it is your fault that the foods you're choosing it. If you choose better Foods, you won't have high cholesterol and you won't need cholesterol medication now again, I'm not a doctor.

[00:47:51] I'm just a big buffoon over here doing a radio show. You know, there are a couple of syndromes of familial hypercholesterolemia [00:48:00] hypertriglyceridemia where you can get triglycerides into the tens of thousands without even really trying that hard so but they are rare and you don't that's not the vast majority of people who have lipid issues for sure, you know, so it's so and you're absolutely right lifestyle modification in even in the pharmaceutical Industries medicines.

[00:48:20] They push for this stuff always say this was studied in. With lifestyle modifications has ever emphasized in any of the marketing stuff. You see as a doctor in your office or you know, even the doctors and fortunately don't have time A lot of times to work on that or may not even be educated in what appropriate lifestyle would help notify patients lipid inflammatory risk parameters, you know, you know, it's funny duck people who cared finally turned to gastric bypass surgery.

[00:48:51] They're told okay gastric bypass surgery. Doesn't work. If you don't change the way you eat start to exercise more and [00:49:00] start supplementing and I say to myself why not try that first why not try doing the things that you will have to do for the gastric bypass surgery to be a success before you have the gastric bypass surgery.

[00:49:13] I mean I agree but you know a lot of times it's getting patients to make that commitment. I don't comply. It's a lot of communities and a lot of times with the extreme obesity. There's. Mental illness associated with it. So, you know, it's very difficult. So I don't want to pick on those people.

[00:49:29] But now I know I know I'm a controlled settings and do you know modify their data? It does work. So listen to this guy. This is Dylan gautreaux. He's in Texas. He says anything in the works that would work like a benzo for anxiety. I guess he was taking them for sleep.

[00:49:50] Well, they're very hard to come off of obviously, you know long to your brain really gets altered by being on the benzos for a long time. But you know, something likes to [00:50:00] lank, you know might be well, I think he said he tried to like yeah, and then you know, I like to augment the ability to produce your own.

[00:50:09] Produce your own Gaba with things like theanine and glycine, you know a decent levels of that can help the Gaba axis. Well, look, he says he tried to like but he was still on benzos at the time. So you really didn't try this Alliance could be a reasonable truck. You need to get down to the person like that.

[00:50:25] If you were giving advice would need to try to get as low as they could on their own and then start working on some things, you know peptide. There's a couple different peptides we can use to help in that scenario and also the nutritional side of it. On the lifestyle Sleep part of it. There's it's a complicated process.

[00:50:43] It's not a matter of here's two of your peptides and I think you'll be okay. Call me quick. So this is the last question will answer it. And then we're going to end the show. This one comes as a second question back from Casey. He said what would what would you use for collagen support before the [00:51:00] surgery?

[00:51:00] I'm guess he's asking for a brand of college and I personally like Great Lakes greatly different college and the drazi sure it's your show. You plug what you want to plug there's a lot of good college ins and and you know that all what which one do you like out in Great Lakes is a wonderful brand, you know, actually use the right now a lot of designs for health brand.

[00:51:20] It's a whole body collagen. It's a reasonably priced but again collagen if it's manufactured properly is clean Great Lakes is a wonderful brand, you know, who else makes what now doctor seeds the Doctor William see just introduced a new car go to dr. Seeds.com and check out. He just introduced a new collagen product.

[00:51:37] Yeah tell. Heard about it here on supremum radio. But yeah, that's one and the other thing he asks is where is the best place to buy bpc and TB for combo? Well, that's a tough question if you want to have a prescribed by your doctor. You should go to your doctor and have them contact tailor-made Pharmacy in Nicholasville, Kentucky and they can prescribe it for [00:52:00] you if you're looking for an alternative.

[00:52:03] To pharmaceutical I mean I prescribed you can look to peptide Sciences.com for pretty reliable product. But there is for research purposes only and its marked as such on the label so you should be aware of that. But really just go to your doctor and tell them you want these two peptides. Tell him he can order them from TaylorMade Pharmacy.

[00:52:28] And if he doesn't know how to order if he doesn't know how to use them. Tell them to join the international. Society and become a member and they'll teach him how to use it and describe it. So there you go. Last question. I'm off the Bell. No, he's just telling us he's off the benzos three plus years now Bravo.

[00:52:43] That's awesome. Congratulations chance. Yeah made, you know, I'm going to tell you something else. I shared this with Ryan over at tailor-made. HCG right before bed has improved sleep architectured undeniably because I've tried not using it a [00:53:00] couple times and I know. My sleep was a lot worse.

[00:53:04] Okay, you think it's because of the luteinizing hormone production, correct? Yeah suspect that's its primary impact. So so I bet you that would go good with some of these other peptides like DSi payer all the good stuff happens at 3:00 and 4:00 in the morning with you know, if you doc if you know the right people that's.

[00:53:23] This is this has been a great show. The medical transformation center.com is where you want to go you want to get this stuff Casey go to dr. Page contact them go to his website and cocktail contact them and learn about becoming a patient and there you go. How's that sound? Sounds good. Alright, that's it.

[00:53:40] It's Friday and I am so glad it's Friday. I can't wait to go home and see Miss Eliza. I thank you for listening. Thank you for watching and we have lots of really good shows planned for next week. We're going to knock it out of the park with. I'm so don't miss them. We'll see you [00:54:00] then.

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