Dr. Jeff Golini, PhD - Dr. Dale Bredesen
Dogs have an amazing sense of smell. Exploiting this gift has found its way from tracking down fugitives to detecting when a diabetic falls into a dangerous blood glucose level. Now science is finding dogs may be able to detect cancers even earlier than available testing methods. PLUS Alzheimer's Disease is the 6th leading cause of death in America and effects over 5.7 million people each year. Dr. Bredesen first appeared on SHR in 2014 after his first trial successfully reversed Alzheimer's Disease in a small group of subjects. Today he has duplicated his success in much larger groups. Chances are good that you know someone suffering from Alzheimer'
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[00:00:00] Welcome back to another episode of superhuman radio. We have a powerful show for you today. And I use the word powerful specifically during the first half hour. We will have signs for humans. We're going to talk about the usefulness of dogs. Can they actually smell cancer? And if so, How can we use dogs to detect cancer earlier than any [00:01:00] type of method we have currently we talking with the dr.
[00:01:04] Jeff golini about that in a moment then later in the show. Dr. Dale bredesen makes a return. You remember he was first on my show in 2014 when he had reversed Alzheimer disease in about 20 patients at UCLA. Well, since then he has reversed Alzheimer's disease literally in thousands of patients not only directly but because of the publishing of his book The End of Alzheimer's so ask yourself this question.
[00:01:32] You probably know someone who has Alzheimer's disease. Why haven't they heard about dr. Dale bredesen work? We're going to find out more little bit later in the show. Of course, we have to thank our title sponsor All-American Pharmaceuticals and EFX sports right now. You get six of the top selling products absolutely free by going to superhuman radio dotnet clicking the EFX Sports Banner ad entering your name and address and you will get six great products.
[00:02:00] [00:02:00] Protein powders pre-workouts creatine products. I mean the list goes on and on and that's because dr. Jeff golini believes that no one should buy anything until they tried it first and he puts his money where his mouth is. This is science for humans with dr. Jeff golini.
[00:02:20] How you doing doctor? Oh, I'm doing great Carl. How about you today? I feel great training has been going good. Sleep has been going good. I mean I just. I feel like I'm actually coming back. I was scared for a while. I got to be honest with you, you know being 60 years old and not feeling good.
[00:02:38] You kind of taught you can sometimes you start thinking. Well, maybe this is it, you know, but no it's not. Try it out. It's not good. So good. Good good. This is a really really interesting topic isn't it? And it's not new. I want to preface our discussion about how dogs can smell cancer in humans.
[00:02:55] By saying that we have known that dogs have been helpful in the [00:03:00] healing of the human condition that dates all the way back to the 1200. The Catholic church has a saint it's spelled st. Are OCH but it's pronounced Rocco and there there was a statue of Saint Rocco. That I remember as a kid. He had a bunch of open wounds in the dogs were all licking his wounds and my father told me back then that if you ever get a cut let the dog lick it cuz it'll heal faster.
[00:03:27] And now we fast forward to today where dogs are actually without being invasive being able to detect cancer in patients before modern scientific methods can detect it. Is this amazing. You know it is when I saw that I thought wow, I mean here's something that in front of our nose and it just makes sense.
[00:03:53] I mean when you think about the. Factory [00:04:00] smells system and it sprayed out a doctor J. I gotta I gotta run some music because the phone did go you're clipping a lot. So will can I call you right back on your cell real quick? Yep, real fast real fast real fast sit tight everybody. Sit tight. Let me just play some music.
[00:05:00] [00:05:02] Okay, I think you're better now. Let's hear you. Yep, I think we got that fixed big time. Okay, so you were saying the olfactory senses of dogs you started there? Yeah, so I had seen some studies that you know dogs literally can smell a mile or two away. I mean, they have a very enhanced system similar to the oh boy you me to most wild animals.
[00:05:34] I mean, you know, that's why you have to not be up when you know from bears or Wolves right lions and tigers. So. That is a built-in benefit and it's been right literally before our noses, you know, yeah, no pun intended and dog has spent so much time with Youmans that they you know, we share we know that this is a fact this came out in one study looking at the microbiome of people with pets and [00:06:00] they found out that they share some similarities in their microbiomes, which means the dogs probably licking things or the people are kissing their dogs on the snout.
[00:06:10] And we are sharing microbes. So domesticated dogs have a lot in common with Youmans, even though they don't walk or talk like us or do a lot of the things that they do. This is seems to be some sort of symbiotic relationship that enables them to know. That when a person has a cancer that it's not only that they can smell it but that it's a bad thing because one of the stories in this and I'm going to let you tell it the guy who had the melanoma behind his ear remember, right?
[00:06:41] So talk about that. What did the dog do? Yeah, so, you know the dog came up and started licking this this small sore behind the guy's ear. And again kind of LED them to investigate that he had he had cancer, you know, and so that means that if the dog [00:07:00] is licking it he's licking it because he's trying to heal it he's trying to make it better.
[00:07:05] So the dog recognized that this wasn't just any old sore that this was something dangerous and when he goes to the dermatologist a biopsy to go. Oh my God, you've got melanoma and this has happened over and over again dogs have detected. Cancers breast cancer prostate cancer they've detected colorectal cancer.
[00:07:29] They've detected lung cancer because they can smell the cancer in the breath in the urine and the feces and even in the skin they understand that cancer is bad. That is the most amazing thing in the world to me. Well, and you know if you've ever been around a sick person or. Even in very ill person, you know who is at the hospice level even our human noses.
[00:07:56] I mean you can smell distinct smells. I mean going to a hospital, [00:08:00] you know, you can smell things and those are things that are Amplified that we can smell them, you know as these dogs can smell through suitcases for different narcotics. I mean, they they can distinguish between different types of Narcotics you.
[00:08:18] Where they're not just going to sniff a prescription antibiotic and you know alert them that it's cocaine or something. They actually can distinguish between the different sense right? And you know think of the drug dealers, I mean they wrap it in, you know, coffee grounds. Yes all kind of stuff to mask it yet that may fool the human scent but not the animal.
[00:08:43] It's amazing. So so this recent paper showed that dogs can actually be trained to differentiate between specific cancer types. They can be trained to detect colorectal cancer from a person's breath [00:09:00] as well as from their fecal matter from their breath. Yeah, well, there's a reason why dogs sniff other dogs, but we just think that it I mean I has anyone really thought to what they're actually doing.
[00:09:14] Yeah, right, right. I mean maybe they're checking each other out to make sure they're healthy. Yeah. Hey. Hey buddy. Can you give me a quick exam? Haha. Yeah. Yeah, and the other thing too is, you know, people don't realize but I think it's a cross, you know. Dogs will come up and lick people, you know, and it could be that they're lacking some mineral, you know, sodium potassium magnesium.
[00:09:38] So, I mean, I think they're dependent upon us for some healing factors as well as we are a pound them as like you said, They always say that a dog's mouth is cleaner than a human mouth. Right? So, you know, maybe some of those microbes are pertinent to some healing properties and such besides just the fact that they can sense.
[00:10:00] [00:10:00] And here's the interesting thing the presence of gut inflammation or non-cancerous colorectal disease does not seem to affect dog's ability to detect the cancers. In other words. They can actually differentiate between precancerous and cancer dogs can also detect lung cancer from a person's breath.
[00:10:19] One study found that a trained dog had a very high rate of accuracy in distinguishing distinguishing between the breath of people with and without lung cancer. This this is amazing. This takes service animals to and completely new level. And even in the summary of the study, you know where they say further research has to be done to improve the accuracy.
[00:10:44] They didn't really tell us what the accuracy was but it seemed like it was quite High. Yes, and you know you and I were talking that we've talked to last couple weeks about these blood pressure cuff. What do you think the accuracy of those are 25% Yeah. [00:11:00] Yeah, I mean, you know and you're saying okay.
[00:11:02] Well the dog is 60% We've got to improve on that accuracy. Well, I think it's more accurate than the majority of the test set Physicians will perform. Yes as most of them are subjective. I agree and and the real. Telling detail in this paper was right after they said about the accuracy. They also said if we could figure out what it is that the dog smell we can then maybe create a machine that will do this.
[00:11:35] Oh, I see I see where you're going with this now. So in other words, yeah, we got to make a machine because we have to have a billing code for this right. How do you build right a billing code in for a dog sniffing? Somebody's butt. Yeah, you can't charge, you know 5 million dollars for a dog. But you know, what somebody is going to take this car because you know again [00:12:00] if we can detect things early on we have a better chance of reversing that ailment than waiting till it's full blown.
[00:12:11] So I mean, I think if. The medical industry was smart, which they they aren't from that standpoint. But you know if we could develop this technology, so to say I mean look at how many people's lives can be extended and or you know cured from early detection and all they have to do is buy a dog that has been trained or by a dog and have them trained to detect these things.
[00:12:40] I know for a fact. That right. Now they have service dogs that are trained to detect plummeting blog blood sugar levels in diabetics and they you know, and and they have collars with buttons on them to summon help and [00:13:00] I think that. My good friend Michelle trains dogs, they live with her for two years.
[00:13:07] They train dogs to be service dogs, and I believe she told me that she trained a dog that was designed that was going to go to a person who is diabetic and I think that they have like in the collar of the dog. They have like peppermint candies that the dog will come over and the person of the peppermint and put it in their mouth and they can save their own lives.
[00:13:28] Yep, I did hear about that. And that is a that is accurate and you know, you just think about the current service dogs now how you know people who are blind. I mean how they can detect they don't just detect where they're going. They feel the human. They know what the human is feeling, you know dogs can sense fear.
[00:13:51] Dogs can say if you got a dog your dog knows when you're not feeling well, you're sick, you know, they want to be by your side [00:14:00] and even you know in dog training, you know. When you walk up to a dog and they can sense fear now. They don't necessarily sense it. I think they smell it. I think we produce some, you know, pheromone or something that indicates that where fearful and think about the dogs mating.
[00:14:20] I mean, you know, they can smell a dog in heat a long ways away, right? You know, right. So here's an interesting story about the intelligence of the dog when I was a kid we lived in Bed-Stuy, Brooklyn. We had a German Shepherd named Friday and Friday was quite vicious with people outside the family and and and so one day there was a shooting up the street from my house, and it was just me and my mother that were home and Friday always bark.
[00:14:55] But for some reason Friday, we didn't know about the shooting all we knew was that [00:15:00] Friday stood by the door of the apartment like on attention, but he didn't make a noise. He just looked at the door and he was there for the longest time. My mother kept going to him Friday. What are you doing? Come on move move, and he wouldn't leave the door.
[00:15:15] We found out that evening that one of the guys that was involved in the shooting was hiding in the vestibule of our part. Now that the number that think about how smart this dog is this dog barked at everybody that walked past the house right? But right he didn't bark then because he knew that if he would have barked my mother would have opened the door and maybe she.
[00:15:38] Got shot right and to this day, I believe that dog knew he stood there he was he was Vigilant and he stood there and he was waiting for someone to come through that door, but he didn't want us to go out there. He didn't want to call us say hey go check this out. That's how smart I believe dogs.
[00:15:59] Yeah [00:16:00] II do agree, you know, you hear all the time people saying well dogs dogs aren't smart. They don't understand stuff. And if you've been a dog owner, you have to disagree, you know, they do understand. They're very very attentive. They're very protective. Of of their families like you you said and if you really pay attention so you can pick up on these things, you know.
[00:16:30] Yeah. I want to take a quick commercial break when we come back. I want to talk about supply side west you just came back from the supply side west show and there's people that listen to this audience at this show that probably didn't get a chance to go there and I want to talk about the manufacturing capacity capabilities of AAP for people out there who have a dream maybe of Lon.
[00:16:50] Supplement can we do that when we come back? Absolutely. All right, let's do this take a quick commercial break and we'll be right back. Welcome back to science for humans. We were talking about [00:17:00] the instincts in intuitiveness of dogs and how they can actually detect cancers in humans want to change it up a little bit because dr.
[00:17:10] Jeff just came back from supply-side West a lot of people don't even know what supply-side West is. It's actually where business to business people kind of get together and if you're looking for. A company to do contract manufacturing for you because you have a supplement you want to launch you could go to supply side west and find the company or you could just talk to dr.
[00:17:31] Jeff because I don't think there's any finer contract manufacturer in the world today than All American pharmaceutical. So talk about your trip there. How was it? Did you have a good time? Did you meet some interesting people? Yeah, it was great. You know this particular Show puts on a West show which is typically in Vegas and Annie show in the spring that's on the East Coast somewhere but it's a very big show.
[00:17:55] So, you know, you have raw material suppliers from all over the world. You have contract [00:18:00] manufacturers you have. People selling lab equipment software bottles. There were even some production equipment people there with display of machine. So it's really a business-to-business show to find things that you're looking for.
[00:18:16] You know when the common person comes by and they go what it's $500 to get in. You know, they think that's ridiculous. But you know in the industry you realize that it costs a lot to put these shows on and you know, only serious people come into the shows. So it was great. You know, we are Booth was kind of Midway toward the back and.
[00:18:38] It was kind of funny by the time people kind of got to us. You could tell they were very discouraged. So they saw contract manufacturing on our backdrop and they're like, oh another one so, of course, we're very friendly. Hey, how you doing? Oh your contract manufacturer. What's your minimums?
[00:18:55] What's your minimums? And then when we would tell them because we have very low minimum. Then all [00:19:00] of a sudden they would perk up and go man. Everybody else was telling me I had to buy, you know, a million pills or you know what so so don't know for the people in the audience's there's somebody listening to the show right now.
[00:19:11] That's had to dream of launching a supplement. That they believed would fill a very important Niche and the thing that's keeping them from even thinking seriously about it is The Upfront out-of-pocket money. So what is the minimums at AAP give us some examples if somebody's coming out with the powdered with a scooper product or a capsule product?
[00:19:33] What are the kind of minimum you deal? So, you know, if you're if you're just getting started and all of the materials are stock we have like 4,000 different materials will help you get going for a hundred forty four bottles and most people will say well how much money do I need 50,000? No, no, you know, you've got five thousand dollars, but I always say make sure you have money for marketing.
[00:19:58] Yeah, don't put all your money into. [00:20:00] You know any type of business investment, you've got to you've got to have capital for inventory and. But really it's really easy, we work with a lot of startup companies Carl, you know help people who have this idea very easily and quickly getting it to Market.
[00:20:20] That's kind of what we specialize in and a lot of times people go. Why do you even deal with that? And I'm going to tell you because years ago when I was a little guy with an idea. Somebody help me there was a big manufacturer in LA and they helped me get started and I always remember that. The same way with my packaging supplier.
[00:20:43] I'm dealing with the same packaging supplier that I dealt with in 1985. I remember pulling my little Mitsubishi truck up to their docks next to all these trucks and they were so generous. They would sell me a half a case of bottles where they would open a case for samples. [00:21:00] And I said one day I'm going to have trucks here and they believed in me and now we're one of their largest customers.
[00:21:07] So again, Everybody has to start somewhere and I really believe in love helping people who have a dream, you know reach those dreams. So that's what makes us different on top of quality and Innovation and all the other things. So, theoretically if if I had a supplement and raw materials and Manufacturing and packaging and even label.
[00:21:29] I know that for small runs you can actually do label. You're telling me a hundred forty four bottles and let's say that supplement cost me $10. I'm just using that because I'm not great at math. You hundred and forty dollars. I mean you're talking about. Yeah, you're talking about a little bit over a thousand dollar investment.
[00:21:48] Yeah, and you are in the business and you know this day and age with being able to sell on Amazon and eBay and it's really easy for somebody to start a supplement line. Now, it's very difficult to [00:22:00] get into distributions and want to sell in the stores that takes time marketing money. But if you're just looking for a little side business.
[00:22:08] I mean gosh to get on Amazon or Ebay is so easy and very lucrative. You know, you don't have you sleeping I was going to say you can have your own website you you probably have you have 300 Facebook friends. Probably maybe more. I mean, that's where you start. You got a hundred forty four bottles to get rid of you got 344 friends on Facebook sell them your bottles.
[00:22:30] And that's how I started I invested and $3,500 and I got 500 bottles and I just sold this product around the gym and I thought well if it could pay for my own use, that's all I'm doing because I developed it for me and that's how I started to you know, enter so whether it's just to pay for your own supplements or you want a little extra spending money gas money man.
[00:22:54] It's a great way, especially this day and age with the internet very very easy to sell. Mix [00:23:00] well and so I want to mention a couple of things, you know, Eliza works for a company that is cgmp. And so they have a list of CMC Jeep cgmp companies in the United States and the list is very short. I thought just about every contract manufacturer out there was cgmp and your company was on the list at Lisa says to me look we give this list out with metagenic.
[00:23:26] She goes look at the company. That's it was all American pharmaceutical. So a lot of these contract manufacturers these guys are doing stuff. Like they have a little Warehouse to doing it all by handicapping your products. They are not cgmp like you are know that the list is very small and me.
[00:23:42] We're in the top 1% of you know manufacture. Which you know is exciting because there's some Fortune 500 companies that are in this space. But no, you know, those are things that you need to ask about, you know Ru cgmp and the thing that we kept saying at the [00:24:00] show is come to us and they're like what we asked three other people if we could tour and they said oh no, we have proprietary stuff.
[00:24:07] We don't allow anybody in and I'm like. No transparency is what about we encourage you to come visit our facility because we want you to see how your products would be made right? There's no secret stuff. I mean that's an excuse to keep people out of your facility because you got nothing to show.
[00:24:24] Well, you know, and let's be honest if you've ever been in a contract Manufacturing. You don't know what's going in those jars. It's not like you could look at that and go. Oh look at that. They use a special kind of beta-alanine just by looking at the proprietary Blends are on paper. You can't tell anything when they're manufacturing this stuff.
[00:24:43] Well, and even our facility, you know, we're set up for two hours so that when we tore there's viewing windows into the production room. So, you know, we don't go into the production rooms because that would disrupt, you know, the staff cross-contamination. So people can get a good tour a guided tour and see [00:25:00] the majority of the operations where again, you know, if you got a little guy who's got a little warehouse and he's got a little capping machine and he's filling bottles by hand.
[00:25:08] You don't want somebody to come in and see what you're doing because you know, We'll get their business everybody, you know can tell you how great they are. But seeing is believing, you know, so again, we we were kind of the hit of the show from the fact we are inviting people to come visit and you know, every time we had a Canadian guy that was just out here recently and he's working on a big project their company is the.
[00:25:36] Working with the Olympics and endurance and they're the major sponsor for all these big Olympic things. Well, he's been in every facility and he had never to at our facility. So he's working on a project that no one else could do. We we were able to accomplish it and he told me after the tour and then he came to visit us apply said he said man, I have never [00:26:00] seen a facility like that.
[00:26:01] He goes. What do you guys say? You don't even portray it as well as what I saw he goes. It was unbelievable the quality the organization the cleanliness the Section 8 he goes. This is what I expect like a drug company to be and run guys exceeded my expectations, you know, so there you go. If you have the dream of launching a supplement, how should people reach out to you if they're seriously interested in launching a small run of a sub?
[00:26:31] You know you can you can email me you can go to drj at all a mph.com or just even find me on social media. Which most people do and just send me a message whether it's Instagram Twitter Facebook, you know and say hey I'm interested in starting supplement line and then we'll I'll give you all of my contact information and we'll have a free consultation to discuss what you're doing and we'll get you on your [00:27:00] way.
[00:27:00] There you go. That's how it all starts thinking about it, you know reach out to me you might as well explore it I think again, you're only. You're only going to be a success. If you at least take the opportunity to explore something. Maybe it's not for you. Or maybe you really don't have a thousand dollars, but you never know until you actually explore and see if that's what you're what you want and who knows the supplement that you have in your mind could be the next best big thing.
[00:27:27] So yeah, I'm just going to close with this how many times have we all had an idea? And then three years later we go. That's the idea. I had look at what these guys are doing with it. I just Eliza just did that to me last night. When I lived in Phoenix. I came out with the idea of creating a baseball cap with 800 819 an ohmmeter LEDs in it to actually reverse balding.
[00:27:49] She showed me last night this somebody came out with a baseball cap, but they're using the wrong. Our frequency of LEDs. Somebody came out with a baseball cap to help reverse balding. [00:28:00] I said, I can't do every I can't do everything. I just can't. But anyway, I'll get good rocket good talking to you.
[00:28:06] Talk to you again soon my brother. Take care. I so stay tuned when we come back. We'll have dr. Dale bredesen on the show for the second time since his original appearance for years ago. We're going to be talking about Alzheimer's disease. Alzheimer's disease is now the. sixth leading cause of death in America today affecting some 5.7 million people a year.
[00:28:34] I first had dr. Dale bredesen on my Show 2014 when one of his early small studies was published that showed that the people who followed his protocol actually there was one guy, how you doing? Dr. Bredesen. I want to get you in on this discussion because. There was one guy who was an insurance guy.
[00:28:54] He was actually going to have to retire early. He was very successful and [00:29:00] after following the protocol in the original test. He actually went and opened up another branch and got right back into business. You remember telling that story on the air? Absolutely, and he started in December of 2013.
[00:29:11] And by the way, he's still doing great. So the most important thing here Carl is that people who have been proved have sustained their Improvement unlike if you simply take a drug and you may get a minor bump but you go right back down to declining so when you're actually attacking the things that are the features that are actually inducing the problem then in fact, you can see sustained Improvement.
[00:29:35] It's and it's you know, the sad thing is that more Physicians are not talking about this and that that I want to talk about that later in the discussion. But before we do that, you have a book anyone who's listening to this interview. This book is a must have and I'm going to tell you something I wrote a Blog the year after.
[00:29:55] You and I did our first show promoting your [00:30:00] approach as the ultimate anti-aging approach that that halt that Alzheimer's disease was just one of the facets of diseases of modernity and that following the bredesen approach could actually just extend your life. Even if you're not somebody who's struggling with Alzheimer's disease.
[00:30:18] So let's talk about the three. Predispositions for developing Alzheimer's disease that you talked about in the beginning of your book. Right. So the idea here, we studied actually 30 years. We had the lab up and looking at what are the molecular mechanisms that drive you into neurodegeneration and especially Alzheimer's disease and what we found is that there are 36 as I mentioned in the book.
[00:30:46] There are 36 different pieces. So this is like anything else where you know, if your if your company is not doing well, you may find a number of things that are contributing to that same. Thing for your brain. We looked at all the different [00:31:00] features and specific Pathways what we found as you said is that it breaks down into a couple of different groups.
[00:31:06] So there are actually subtypes of Alzheimer's disease. So type one Alzheimer's disease is. Kalama Tory or hot and anything that generates chronic inflammation. It can be your leaky gut. It can be that you have undiagnosed Lyme disease. It can be Bartonella the visia it can be oral bacteria that have gotten into your brain and that's been something that's been discovered.
[00:31:30] You actually can get oral bacteria in your brain. It can be various mold species. It can be spirochetes on so anything that causes chronic inflammation you're. Fighting those microbes by making the amyloid that we associate with Alzheimer's which actually kills the microbe. It is an antimicrobial.
[00:31:53] So you are trying to protect your brain then type 2 is atrophic that is [00:32:00] loss of the very nutrients hormones and growth factors that are required for keeping your brain. Supported you have a tremendous number of. You have a tremendous number of synapses in your brain about one quadrillion. And so these things need the support of nutrition hormones and growth factors.
[00:32:28] And so when these start to go down you cannot support that Network so you actually downsize and part of that downsizing is producing again the same amyloid that I mentioned earlier. It's we think of amyloid more and more now like Napalm if you've got Invaders you. Down the Napalm but when you do that, you're also having less arable soil.
[00:32:49] You're literally downsizing your country. So that's type to then. There's a type 1.5 which actually has some of both and that is for those of us [00:33:00] who've eaten too much sugar who have insulin resistance and glyco toxicity and that's because you get both the inflammation. Of the sugar attaching to your proteins.
[00:33:11] We measure it as hemoglobin A1c, of course, but it attaches to many proteins and it causes inflammation because you recognize these as altered proteins and on the other hand you also now have insulin resistance. So you're not responding to the insulin trophic activity. So that gives you part of the type 2, so that's type 1.54 sweet Alzheimer's and then type 3.
[00:33:35] As you mentioned earlier is the toxic pipe and this is awesome looks very different. It tends to occur in younger people. It can be associated with depression as well. These are people who often have a non amnestic presentation. They have trouble organizing calculating sometimes coming up with the right words and things like that.
[00:33:57] So that's type 3 or toxic [00:34:00] Alzheimer's. So you can actually break these down into subtypes and you need to treat them differently to get the best results. Okay. So wow, I love having you on the show because I become like an ADHD kid. When you start saying some of these things in my brain starts connecting dots one of the things that I've really been doing a deep dive on in my audience knows it.
[00:34:22] Is the is iron accumulation in the body, and and I don't think I think that we all have a unique. Threshold for what is considered iron overload to us specifically because of our evolutionary gifts and and so on and so I'm learning that some people may have what is considered from an epidemiological standpoint at you know, in their tea IBC there are 240 that's considered the low end, but there's but they're showing.
[00:34:54] Signs of of iron overload and one of the Hallmarks of iron overload is [00:35:00] in the entire body becomes inflamed I would imagine the brain as well. So does iron play a role in in the hot type of Alzheimer's? Great point and yes, it does. And in fact people with high Barrett ins are at increased risk for Alzheimer's it's not thought to be a huge player just because there aren't as many of us who have that as for example sugar toxicity, but yes it does and so in fact, you do want to know your ferret and you do want to know your iron status and if you have too much you actually make the amyloid guess what the amyloid the gene that is with that results in.
[00:35:40] About the Emily which is called amyloid precursor protein or a PP. It specifically has an iron responsive element in it. So one of the things that you're making this amyloids to protect yourself against is too much metal and that's true for copper. It's true for zinc. It's [00:36:00] true for iron. It's true for for mercury.
[00:36:02] So in fact, it is an it is a metal binding protein. So again, you're trying to protect. Stopping by the way, if you don't have enough iron, if you're anemic, you actually are at risk as Professor Bruce Ames was the one who developed the test for carcinogens the so-called AIDS test he has he has pointed out to little iron.
[00:36:25] Damages mitochondria, so you know for as for so many things in the human body too much bad to little beds. You've got a sweet spot that you want to be in and that's true for so many of these things. Dr. Bruce Ames was on my show in. 2007 talking about methylene blue and Alzheimer's disease. How about that?
[00:36:49] Okay, this is one of the benefits of being on the effort to 13 years. I've accumulated such wonderful guest interviews, okay. When we talk about [00:37:00] testing and you talk about the sugar and and glycolysis, what about fructosamine testing? Could this be more valuable than hba1c if we're talking specifically about proteins being ugly.
[00:37:16] No, it's really good point and people don't typically test that but again anything that is going to trigger that pathway of when you look at the amyloid precursor protein, there is literally a molecular switch. It's kind of amazing molecule and it sits there in your cells and mostly in the neurons and it can be cleaved at a single site to give you two peptides that are synaptic blastic.
[00:37:44] In other words. These are two that actually. Help you to make and maintain synapses thus making and maintaining memories that same protein can go in the bad Direction. So literally could be the good guy or the bad guy. If you don't have the appropriate support the appropriate [00:38:00] nutrients the appropriate hormones the appropriate growth factors Etc or you've.
[00:38:04] Too much, you know Iron too much microbe exposure, etc. Etc. Too much inflammation, then it can be cleaved at three sites which are called beta gamma and caspase sites and that produces for peptides we call these The Four Horsemen because they are like the Four Horsemen of the Apocalypse so you can go bad and that's basically saying things are not good when you're going to downsize this neural network.
[00:38:30] And that's what you're looking at when you see a brain with Alzheimer's disease. So talking about the brain and kind of circling back into the iron you talk about a blood-brain barrier test in your book. So number one, how is that test perform and who can perform it and number two is the high accumulation of iron in the brain a breakdown in the blood-brain barrier or is this iron get in no matter what you do?
[00:39:00] [00:39:00] Yeah, good point. So for to test that there are a couple ways to go but the typically way that we typically use is called the cyrex array 20. So cyrex has set up a whole set of arrays and they look at different things. They are looking at your body's response as Auto antibodies because something has broken down.
[00:39:22] So as an example cyrex array to looks to see whether you broken down your gut. So if you have leaky gut you want to know your cyrex array to and if it's abnormal you want to heal that up cyrex array three looks for example at its whether you have intolerance to various peptides that are associated with gluten and gliadin as so many of us do and then cyrex array 20 looked at the breakdown of the blood-brain barrier.
[00:39:53] So it looks specifically at. Proteins that have been released that you now form Auto antibodies [00:40:00] against because of the damage and I should say one of the earliest changes in the Alzheimer's brain is an abnormality in the blood brain barrier. So it's a contributor. It's not the only one but it is a.
[00:40:13] And the iron story is you mentioned there are actually two parts to it. There are some effects before the blood-brain barrier is broken down. But of course they can be worse after the blood-brain barrier starts to to be broken down and it's not an all or none where you have zero blood-brain barrier, but it is compromised.
[00:40:31] Our cellular telephones on your radar. Now, you know, obviously you've had a lot of time on your belt your protocol. We're going to talk about the recent paper when we come out of this break, but I want to get this in first. There's a lot of good research being done that shows that the RF radiation from cell phones has an acute effect on the area of the brain closest to.
[00:40:59] The [00:41:00] radiating point that creates a high degree of insulin resistance in that brain area for a period of time. Well after the phone call has ended and we know that insulin resistance of the brain is one of the factors leading to dementia and and perhaps Alzheimer disease our cell phones on your radar right now, or is it something that is it's too much of a third rail to even get into.
[00:41:28] Yeah, they're absolutely I'm later on so we just talked about type 3 which is toxic Alzheimer's and we have written about and there's been a lot of published on key no toxicity. So things like Mercury and bio toxicity. So things like mycotoxins actually produced by molds. These are toxins that you respond to.
[00:41:49] They both unquestionably can contribute to Alzheimer's disease. So what you're talking about now is a third Group, which is physical toxins. That's EMS. [00:42:00] These are actually Fields electromagnetic fields, and they absolutely can come from cell phones and all sorts of Wi-Fi and all sorts of other things.
[00:42:09] And of course we are Deluge with this right now. It's just that at the moment. We don't have a simple of a test for this one. So you can't just throw in a blood test and say aha. Let's see where you stand with your EMS. So tougher to manage right now than the other two where we can say. Hey, here's what your Mercury level is.
[00:42:26] Here's what your urinary mycotoxins are. Here's your Troy Casa scenes your ochratoxin a and things like that. So you're right emfs are a concern. There's more and more evidence that these are a problem whether it's through affecting calcium channels in your neurons. Or something else but whatever it is.
[00:42:44] We need a better test to determine whether a brain has been damaged by EMS. Okay. So now let's jump on mycotoxins for a second. So we there is a large movement afoot from people [00:43:00] who now avoid things like swiss cheese and mushrooms Bruges that used to be heralded as a health food in the 70s. Today is avoided by these people because there is a consensus now that bombarding the body with fungi is probably not a good idea now juxtapose that over.
[00:43:24] The fact that we have a high degree of people today that present some sort of fungal infection even a toenail fungus which could be the canary in the mine that the body is is battling it is it as simple as eliminating these fungi type foods from the diet and and doing a round of Lamisil to eliminate this or it is the whole mycotoxin thing a lot bigger than that.
[00:43:52] It's a lot bigger than that actually and in fact a lot of this is inhaled is even more concerned that ingested and the [00:44:00] old idea was oh you're just eating this stuff. So quit eating it. That's really not the most important route. The most important is to be inhaling these things and we get that typically from things like water damaged.
[00:44:14] By the way, a wonderful book just came out from dr. Neil Nathan who's one of the experts in this area and has written a book called toxic and goes into these various issues. He talks extensively about mold and mold exposure, you know, we'd all like to avoid this because it's a pain it's like what do we want to even get into this?
[00:44:35] Because unfortunately it's complicated but the reality is it is causing a number of diseases, unfortunately. It is contributing to cognitive decline. It can contribute to Parkinson's disease. It is causing chemical sensitivities. It is causing allergic responses. So in fact mold toxicity and the toxicities from these various.
[00:45:00] [00:45:00] Biotoxins made by the molds such as tricot essenes ochratoxin aflatoxin blio toxin, you can actually measure these in Europe. So actually there are now good lab tests for these. So at least you can take a look and see where do I stand if you are low on these things great, then you're not you don't have a significant exposure and on the other hand.
[00:45:21] If you find that you're very high that you need to look at things. Like what is your exposure and there's a thing called the Fermi? Erm. Which is actually from the Environmental Protection Agency. So this is the EPA relative mold index and you can get this you literally go on your computer and look up Michael metrics.com NYC o metrics and they'll send you a little thing of like a Swiffer Duster sort of thing.
[00:45:48] You can dust up send it back to them and they'll tell you what species are there to what extent you there there and whether you have to be concerned and you want your score to be less than 2. [00:46:00] Of 0 is actually average 50 percentile for the entire country. So already it to your above-average you start getting up at four five ten, you're way above average in terms of the actual mold species that are there in that space whether you're measuring your home or your workplace.
[00:46:20] You know, what's really sad about that. I live in Louisville, Kentucky. And this is the mold capital of the country this the Ohio Valley is in fact, I spoke to a a allergist many many years ago really nice guy and he said we have more problems with allergies and Louisville than anywhere else, except.
[00:46:45] I think one of the some town in the Carolinas is pretty close to us, and he said it's because we living in a soup of mold. And that doesn't make me feel good now that you said that so I'm going to try the Army test myself. I want to take a quick [00:47:00] commercial break when we come back. I want to talk about the recent paper that you just published.
[00:47:03] Okay, and I want to tell you I want to tell people that you can go to amazon.com and you can buy the book the end of Alzheimer's and you should buy this book if you have anyone in your family. Or you are worried that you may develop Alzheimer's disease because you could put the brakes on it now, but more importantly by this book if you want to read a protocol that will actually extend and improve your health span to match your lifespan because this book is so much more than just about Alzheimer's disease stay tuned.
[00:47:40] We'll be right back. Welcome back to super human radio we're talking with dr. Dale bredesen about. Ending this Alzheimer's epidemic. before we talk about this study. I have to tell you something interesting. My girlfriend Lisa profumo is very very good friends with the David and Joel [00:48:00] oisin and she said to tell you that your daughter tests is beautiful.
[00:48:05] So thank you so much that you go actually and test test is just graduated from Berkeley a couple of years ago and she is now training to become a health coach in this protocol. So she's now beginning to advise people on what to do about their about their brains. And the reality is just what you said.
[00:48:25] This in fact should be a rare disease and we had vaccines have a vaccine for polio for example, but the way. Go at this is a 21st century vaccine. It's not an injection. It's an quote injection. You are literally getting a personalized program that will help you to avoid Alzheimer's and in fact, we can do this.
[00:48:50] We're seeing this all the time now prevention and early reversals are the easiest way to go. It's the ones who are very far along that are tougher to [00:49:00] turn around. But they can turn around it. Just that the the the tasks are much more heroic. So let's talk about the research that you have just published talk about that.
[00:49:10] I did not have a chance to see it and I couldn't pull it up during the break. Okay, so this just came out and so it's open access. So anybody can access it freely online. It is published by the Journal of Alzheimer's disease and parkinsonism and it describes 100 patients who all had documented Alzheimer's or pre.
[00:49:35] And these people all improved and we have documentation of improvement in their cognition. We also in some of them have had electrophysiology. So ceg's for example or evoked responses and shown improvements in those. So it's hard to it's hard to cheat a EEG machine and then of course the third is some of them had MRIs [00:50:00] showing improvements in volumes of areas of the brain, so.
[00:50:04] These things and some of them had just dramatic improvements of 12 points on a on a mocha test out of. 30 point scale some look at it goes from 0 to 30 and some of these people had just dramatic improvements in the moment others had less dramatic Improvement and one of the things that we're trying to understand is why do some people respond so dramatically.
[00:50:31] And some people respond not so dramatic. Some people don't turn around one of the features of the Earth. The people who are later actually have a less likelihood that you have to go. You have to literally adhere to it more seriously to get that Improvement in people who are lazy, but we have had some who have in there are some described in that table in the paper where had they have mocha scores of 0 now if your normal your [00:51:00] mocha score should be.
[00:51:00] 28 29 or 30 this basically tests things like your memory your ability to follow directions your ability to repeat sentences your ability to do simple calculations things like that. So it's literally testing different areas of your brain for the. To have who are down 27 down to about 20. Those are people who have MCI.
[00:51:26] That's pretty Alzheimer's just like you can have prediabetes. This is pretty old timers, but you're headed there and that may go on for a number of years before you have full-blown Alzheimer's when you're down in the teams and in the single digits that is full-blown Alzheimer's and the average for all Alzheimer's patients.
[00:51:43] Sixteen point two so we had people for example who went from 17. They had Alzheimer's to 29 which is back into the normal range. We had on the other hand people who went from 20 to 21 Well, normally you go downhill. Okay, they went uphill but they didn't go uphill [00:52:00] dramatically. So we want to understand why it is that some people respond so much better.
[00:52:05] And as I mentioned one of them is being late in the course, no question tougher the ones that are earlier easier the second thing is. The ones who followed the protocol if you if you didn't do parts of it you didn't do as well in general and then the third part was if you have the toxic form type 3 you really have to focus on those toxins.
[00:52:25] It's a little tougher than type 1 and type 2 to improve. Do you think that therapeutic phlebotomy could benefit the ones that are toxic to could you know assuming that blood is a closed system and you can unlike your oil you can change it periodically, you think there's any role in therapeutic lobotomy for those who are suffering from the toxic timer?
[00:52:49] You know, that's a great point and there maybe we actually have not been using that particular modality. We've been using binding up the toxins typically things like cholestyramine. Well [00:53:00] call Clay in addition to supporting liver supporting supporting kidney and by the way there. There's another wonderful book that came out not long ago the toxin Solution by dr.
[00:53:11] Joseph possess or know another good book to look at that is all about especially chemo toxins. Not so much about biotoxins. So between those two books the one from dr. Neil Nathan, which is really about biotoxins and one from Joe pizzorno this about chemo toxins very helpful in dealing with toxicity and there are multiple ways to do is and as you said, we are literally living in a toxic soup, we have you know, we all know.
[00:53:36] That carcinogens but you don't check dementia gyms. And in fact, we're exposed to a number of these things that actually can affect our cognition. So you need to know about those and then make sure that you decrease those and had there's a whole set of thing and includes things obviously like eating things that are not full of pesticides and things like that and not increasing your exposure checking your army [00:54:00] score making sure that you don't have toxic mold exposures making sure that your kidneys.
[00:54:05] We are working well for excreting this people do things also like infrared sauna to literally sweat out some of these toxins and using a non emollient soap. So on and on there are some wonderful protocols to decrease your toxic exposure because you're absolutely right. So many of us are living in a toxic soup.
[00:54:27] You can help if you're observant of. You can't help notice the level of gut distension in our population today. We have people who are relatively lean who look pregnant. They're men and their women. This is Barrel. Everybody's got this Barrel look to them today which through my own Deep dive into this topic.
[00:54:53] It's not necessarily visceral fat. It actually could be. Complete inflammation from the [00:55:00] esophagus to the anus and then sibo Gas building up and you blow up like a barrel and there's even been a study done and I couldn't find it for the life of me, but I read it about three years ago. They looked at waist line girth.
[00:55:18] And and subcutaneous fat and what the study came away saying was that while waste lines are getting bigger. It's not because of the fat accumulation which to me says our guts are getting bigger. We're actually starting to look more like. Australopithecus robustus nowadays with with our gut starting at the thorax and not going back into the pubic bone.
[00:55:44] What what role does the gut dysbiosis that were just starting to tap into do you think the role it's playing in the development of dementia? It's a huge role. So I'm glad you brought that up. [00:56:00] In fact, there was a nice paper published from the Kaiser system by an epidemiologist a few years ago. So it's showing the just measuring the sagittal abdominal distance because you're going literally from.
[00:56:13] Your unbelief is back to your back just measuring that distance and CEO same ideas. Your girth will give you your likelihood of developing Alzheimer's disease. So yeah, if your way big in that area that you need to be more concerned on the other hand, you know, we do have people who are very thin who end up getting Alzheimer's as well of again atrophic type of Alzheimer's is typical.
[00:56:36] So you're absolutely right big gut is a huge player here for a number of reasons. You mentioned the inflammation. Very important one of the most common reasons to have systemic chronic inflammation, which you can actually trace the molecular pathway from systemic inflammation to the very [00:57:00] molecules that give you Alzheimer, 's the ones that cut the appe that we talked about earlier that give you the for fragments before Horseman.
[00:57:07] These are increased by NF Kappa B, which is a mediator of the inflammation so. When you have leaky gut and you can check that with cyrex to array. And by the way, I have no inner mean. I have no involvement with cyrex at all. We're agnostic. We're just saying whatever works best to prevent and reverse cognitive decline.
[00:57:30] That's what we're interested in. So cyrex to will help to show you that so having a leaky gut is as you know, incredibly common. The second thing is yes, whether it's bloating whether it's dysbiosis your bacteria. Your microbiome is also associated. In fact that microbiomes in Alzheimer's are different than the microbiomes in normal.
[00:57:56] And so you want to optimize your microbiome. You want to heal your [00:58:00] leaky gut Step 1. Step two you want to make sure to take probiotics and prebiotics and as you know, if you can get them from your food from fermented foods and then things like jicama for the prebiotics that's so much the better but if not take a good probiotic take a good Prebiotic.
[00:58:17] You want to optimize your microbiome. So no question that gut is related. And by the way, also an important role in Parkinson's disease for the gut and that's been demonstrated beautifully in research. Just this case. About a year and a half ago. So I'm going to talk about supplements little bit later in the show because you there's a couple supplements that you really like and I'm going to talk about the probiotics as well.
[00:58:41] But I want to talk about real quickly since you were talking about gut and diet. You're a big proponent of something you call flexible keto ketogenic diet. I think you call it. Can you explain. What you mean by that because the ketogenic diet today. He's taking on almost a zealot like [00:59:00] the vegan diet, you know and button and unfortunately, it's a therapeutic diet that has real benefits, but too many people are now bastardizing it talked about the flexible keto diet that you talk about in the book.
[00:59:14] Yeah, so we call it Tito Flex 12/3 and the whole idea again is we are trying to drive your biochemistry given your genetic background. We for each person want to drive your biochemistry in your neurochemistry toward what you'll give you optimal cognition and reduce your probability of Alzheimer's disease.
[00:59:37] So what it turns out is that when you are beginning in this occurs decades before you're full. No flavors, you begin to have problems utilizing glucose within your brain. This is likely at least in part due to the insulin resistance. You don't have the insulin function that you did before. So you have a classical pattern which looks like literally like [01:00:00] two L's on your head one at your right ear one of your left ear your temporal region and your parietal region have decreased glucose utilization.
[01:00:11] And so. Or you want to have an alternative fuel source, which is ketones as you know from burning fats. So we want to give you metabolic flexibility. You can burn fats you can burn glucose. Although we prefer fats you tend to do better with your cognition. So there are a couple of parts to this diet and I should say very important as you said earlier.
[01:00:34] Everybody's getting into these ketogenic diets. We're not talking about bacon here. This is a plant rich. Ketogenic diet because that's actually what gives you the best cognition want to stay away from the nitrates and things like that. So step one is you want to have 12 to 16 hours of fasting at night.
[01:00:54] So if you finish your dinner at 7:30, you don't want to start eating before 7:30 a.m. And by the [01:01:00] way, if you're a belief or positive that's a genetic of the most common genetic risk factor that in fact you want to give it 14 to 16 hours of fasting fasting turns out to be very. For so if you have zero copies of apoe4 and there are simple ways to check this out then your chance during your lifetime is about 9% If you have a single copy, it is about 30% if you have two copies, it is over 50% So most likely you will develop Alzheimer's during your lifetime.
[01:01:31] If you don't go on the appropriate prevention, so. Kito Flex as we talked about in this has been researched and written extensively actually by my wife. Dr. Ayuda roisin bredesen. Who is an integrated physician and by Julie gee who's the one who started the apoe4 got info website is commended for Distributing information on EA Polly for and has thousands of people who followed their information on a belief or so step one.
[01:01:58] You want to have the [01:02:00] 12 to 16 hour fast. You want to have a three hours at least between finishing your dinner and going to bed that you want to have a plant Rich ketogenic diet. Which means hi. Good fats avocado oils things like that. Stay away from. The trans fats obviously and then the idea is the reason it's called Quito flexes Quito.
[01:02:24] We want to drive you into ketosis and you can get a simple inexpensive Ketone meter for about $25 from Amazon for example and check you want to get yourself up above 1.0 millimolar beta-hydroxybutyrate in the one to four millimolar range. And so you want to have the fasting you want to have a. The flexitarian part means you can do this with or without me.
[01:02:49] You can have some need to be if you're going to do that fine, but try to make it grass-fed beef. Try to make it past your chicken. Try to make it wild caught right because [01:03:00] what are the things I've argued about on this show. Dr. Bredesen. Is that any diet? That produces ketones is a ketogenic diet and as an exact extreme example of that is this if I fast all day long and eat 12 teaspoons of sugar the reality is that.
[01:03:22] I'm probably going to be producing a lot of ketones until my insulin May Spike. Theoretically that is a ketogenic diet any diet that produces Ketone. So do it your own way, but monitor your Ketone levels do it the way that you're comfortable because the way you're comfortable you're most likely to do for the longest period of.
[01:03:41] Yeah, that's why we call it Tito Flex, right exactly. I love it not. Yeah, it's not it's this a plant Rich ketogenic diet. Not a bacon which ketogenic diet. Is the Magic in the in fat and obviously the magic and fasting actually comes from Evolution. We would never designed to eat right before [01:04:00] bed at night.
[01:04:00] We would never design to eat in the middle of the night because we're hungry metabolic flexibility is a gift that was passed on to us from an evolutionary gift and we've destroyed it in this in this modern time now, but is the magic of the fast otology or is there more to it than that? Yeah, there are a number of things on top of G is one of them.
[01:04:22] So the autopsy does help and it is now helping you to remove the very damaged proteins and damage lipids that accumulated. You're absolutely right the problem with can. If you're stopping when your car every two seconds to fill it up with gas the gas is starting to view a drip all over your car.
[01:04:40] You can catch it on fire. You're not getting anywhere as you keep fueling. This is the same thing with your body. You can't keep fueling all the time it your body is not made to handle that fuel wear over fuel. So you want to have the periods of fueling and you want to have the periods of fasting?
[01:04:59] It's [01:05:00] absolutely critical for Optimal Health. And yes, as you said otology is part of it, but breaking down your fats getting rid of that glycogen so that you're now able to make those Ketone bodies that are so helpful to brain function. That's another part of it and there are multiple others that this is a time for healing.
[01:05:22] Okay, one more thing before we take the brake and let me go back and look at my notes because I'm actually making notes as we talk practitioners can become certified in your approach. How do they do that? And and what level of existing education or prerequisites do they have in order to be certified in the bredesen?
[01:05:50] Right. So we've had actually now trade over 1,500 positions from 10 different countries and all over the United States and actually 15 or sites were [01:06:00] involved with this paper that you mentioned that just came out that describes a hundred people with Improvement. So people all over and in other countries are practicing this approach and we set up a course which is reversal cognitive decline and it is currently given by The Institute for functional medicine.
[01:06:17] So if you just look, Institute for functional medicine and if you are a practitioner you can take this as a as an MD as a Dro, you can take this as a neuropsychologist you can take this as a nurse. So practitioners can take this you can take this if you are a DC an AAC so any of the above in addition.
[01:06:39] There's doubt a second course that has just started this month also through the institute for functional medicine, which is specifically for health coaches to learn to be a health coach using this reversal of cognitive decline protocol. So there are the two different courses both offered by The Institute for functional medicine [01:07:00] beautiful.
[01:07:00] We're going to take these online by the way. Okay take these courses online and we've had them in the past where people came to a specific site we have been. Dallas Los Angeles and San Francisco Etc. But you currently you can take it online through the institute for functional medicine. The book is the end of Alzheimer's it's an amazing book and regardless of whether you're fighting against Alzheimer's worried about getting Alzheimer's know someone who has.
[01:07:26] Or you just want to live a better life this book is for you. And for those of you who don't have the time to sit and read it's available on Audible Lisa got the audible version and whenever we travel we listen to a few chapters of the book. Because I don't I don't have I just did my 23andMe. I don't have any of the markers for Alzheimer's.
[01:07:48] In fact, I have a bunch of markers for longevity, but I haven't lived the perfect life. So I'm still concerned but more importantly I use a lot of the [01:08:00] things in your protocol to be a better human. I stopped eating at 6 p.m. I don't I don't I don't eat until post-workout I train first thing in the morning.
[01:08:10] You know, I always get at least three hours between my last meal and when I go to sleep, there's certain supplements that I want to talk about when we come back that I use that you talk about in the book. And as you point out you're agnostic you have no vested interest in promoting these other than you have found value in them in your practice.
[01:08:28] We're going to do that when we come back stay tuned you're listening to superhuman radio. Welcome back we're talking with dr. Dale bredesen. The book is the end of Alzheimer's it's been out for a while. If you haven't heard about it ask yourself. Why?
[01:08:45] with more and more practitioners being trained in the bredesen protocol will see more doctors moving towards treating patients like this, but the reality is that if you know someone a loved one who is suffering from dementia and [01:09:00] Alzheimer's go into your doctor and say what do you know about this book the end of Alzheimer's.
[01:09:05] And if they immediately dismiss it find a new doctor because this is a lifestyle disease and by that I mean if you come if you work at a factory where they use toxic chemicals, you're going to get something from the exposure to that. It's part of your lifestyle. This is a lifestyle disease take umbrage in that because that means you can change your lifestyle and change your outcome.
[01:09:31] I mean, it's really very freeing. So, dr. Bredesen, you mentioned some supplements and there's not enough time in five of these shows to cover the the vast treasure that this book is in so many different areas, but you talked about a couple supplements and I want to ask you about them specifically.
[01:09:54] One of them is SPM active from metagenic. So actually two of them [01:10:00] come from energetics SPM active and magnesium L 3 and 8. What is the value in the Alzheimer's model of for these two? Yeah, and by the way, you can get magnesium 3 and 8 from any know many places. So it's not just one thing. They're right in the bottom line here is that we're trying to drive your biochemistry to an optimal biochemistry for your brain function.
[01:10:23] And the and one of the things that is helpful for many people is to reduce chronic inflammation. Now again, it's important to find out what's causing this chronic inflammation. Is it because you've got a leaky gut you don't want to just. Not the information you want to know why it's there and get rid of that.
[01:10:40] So you want to know if you have a leaky gut you want to know if you're exposed to mycotoxins. Do you have other problems? Do you have metabolic syndrome? If so, you want to have a program for that? So yes SPM active is simply. Something that was actually worked on with dr. Charlie Sirhan [01:11:00] out of Harvard.
[01:11:01] It is what's called resolve ins so these are things and by the way, they're related to Omega 3s. So if you're taking you know high level of Omega-3s and you're doing well, you may not need the SPM active. This is to help you have resolution. So there's there are two parts of the inflammation.
[01:11:19] There's an anti-inflammatory things like curcumin and things like Omega-3s, but there's also. Of ongoing information. So if you've got ongoing inflammation step one resolve it step two then prevent further inflammation the Magnesium 3 and 8 is very different. This is three and a allows the Magnesium to be carried into your brain with a higher efficiency.
[01:11:43] This was developed actually MIT from work from Professor. Dr. Gross Alou who developed. Few years ago and in general we are we do have slight decrease in maybes and again if you don't then you don't need this but if you do have a [01:12:00] slight decrease in magnesium in the brain as people with Alzheimer's often do then taking some magnesium 3 and 8.
[01:12:06] Typically you want to take it in a lady of the evening because it can make you sleepy little bit and people can do better. But again, we're driving you towards the optimal biochemistry and that includes magnesium. You are loved that includes vitamin D. If you are low curcumin another one that I find very helpful if you're pregnant alone is well, that's another one and then for some people very helpful to have exogenous ketones when you first start if you are not able to produce ketones and that's very typical for people who either been in sugar for years or if they are very thin so that they.
[01:12:46] They can't metabolize the fact they don't have the facts of metabolized to produce the ketones. So to get them into ketosis at the beginning that they may have to take some Ketone salts or some MCT oil. So one [01:13:00] of the things we found that is associated, the most with Improvement is getting people into ketosis getting rid of that inflammation getting rid of that insulin resistance and then getting rid of those toxins.
[01:13:11] Those are the big ones to get. With optimal cognition, I recently had dr. Satis Rao on the on the show. He published a study that kind of went viral on the internet that showed that people who have sibo tend to have high degree of lactic acid producing bacteria and these people tend to also be and it's a different type of like so so it's D lactic acid, which is the lactic acid made in the gut.
[01:13:41] Versus L lactic acid which is made in muscle. So it's easy to detect this particular phenomenon, but during the show, you know, we talked about it. I said, you know, is there a possibility that. More is not better when it comes to probiotics could people actually be and it takes look if you have [01:14:00] digestive motility issues.
[01:14:01] If you have low hydrochloric acid levels in your gut, which means that the pH is rising then the small intestine becomes easier to inhabit and then pounding down, you know vsl number 3 with 450 billion cfus per packet and pounding down Prebiotic fibers. Are we not potentially? Problem. I kind of feel like the the probiotic message should be altered to say it's not all good.
[01:14:31] We have more to learn. That's exactly right. And again, there's a sweet spot as we talked about earlier. So this is all about optimal physiology. You have a suboptimal physiology when you are developing cognitive decline, whether it's from Alzheimer's or whether it's from other conditions, like Lewy Body Disease, for example, 1 million Americans have Lewy Body Disease.
[01:14:53] It's a relatively common problem. So it's all about optimizing your physiology. And as you indicated one of the [01:15:00] most common things is that we. Who's that gastric acid? And as dr. Jonathan Wright has shown over the years losing that gastric acid is associated with a number of things one of them being macular degeneration, which is actually the neurodegenerative disease that is more common than Alzheimer's in this case.
[01:15:18] Of course, it affects your vision. So you're absolutely right getting optimal gastric acid making sure that you don't have overgrowth making sure that you've got an optimal gut function and optimal gut. The crow biome huge, you know, just when you said that about the macular degeneration, which is on the rise in our population, by the way, and and I all of a sudden I had a vision of Larry the Cable Guy promoting Prilosec, you know, wondering proton pump inhibitors, you know, when the food you like doesn't like you, you know take Prilosec know when the food you like doesn't like you don't eat that food.
[01:15:58] Yeah exactly. Did you [01:16:00] know for many people? It's actually having the right amount of acid is more important this idea of ppis and pounding these things. They are associated with all sorts of side effects Sophia. Please be careful about inhibiting your gastric acid. It's there for a reason well, and I want to close on this.
[01:16:18] I did a show not too long ago that showed that. Baking soda 30 minutes before a meal mitigated a lot of the symptoms of certain autoimmune disorders and what they discovered was not because it reduces. But the reflex of the gut is to increase acid when you use baking soda it momentarily reduces the acidity of the gut and the gut comes back and pounds more acid into the gut which apparently helps not only to digest the meal you're about to eat but food that has not been digested that's [01:17:00] lingering in your gut.
[01:17:01] So when we talk about the the environment of this the gut acid is important. Very important. Absolutely. One of our friends was on ppis for years and literally couldn't get off and when she got on the right diet doing the right things. She's actually been able to come off these completely as you know, your lower esophageal sphincter so called Ellie s is closing because of the sensing of the acid.
[01:17:26] So if you if you're taking these things you're not allowing us to get the very acid that it. To close down and prevent that gerd you're also not getting the nutrients. For example, you're not getting the zinc. You're not getting the B12 that you need. You know, I'm proud to have you on the show. I was just thinking, you know, I have had so many amazing guests on the show in 13 years and you're one of them.
[01:17:48] I want to thank you so much not just for coming on the show and talking about it, but for the for the work that you're doing and the courage you have to go out there and say. [01:18:00] There's this things we could do for these people a lot more important than giving them an hour step prescription. So wonderful, they work and they work a lot better.
[01:18:08] Yes. Thanks so much Paul. Appreciate you having me on let's all work together to make Alzheimer's a rare disease. There you go. Thanks. Dr. Preston. Take care. And there you have it man. That's exciting stuff. I and that's all I've got for today. Actually, we're off tomorrow because I have some things I have to do.
[01:18:26] But Friday, we will have an episode of ReNew Life RX show. We do have a winner that sent the question that were using and we also have a runner-up that will also both of them will receiving gifts the the winner whose question we will be focusing on tomorrow's show will receive $200 worth of product from prototype prototype nutrition and the runner-up is going to receive some free live on lab products vitamin C.
[01:18:54] Stuff like that. So that's it for today past the show around save [01:19:00] some lives will see it there. We'll see you Friday off tomorrow
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