Ronnie Milo
Many attribute Insulin-Like Growth Factor with bad outcomes as it relates to cancer and insulin resistance. There are those who even go as far as to limit IGF production to increase longevity. But what if they are completely wrong?.
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SHR # 2425 :: RLRx: Is IGF Misunderstood
Show Notes:
[6:12] IGF-1 is very misunderstood.
- It can be both good and bad.
- It is great for muscle growth if used correctly. If overused, it can be detrimental.
[9:15] Physiological role of growth factors.
- It has long been thought that IGF-1 causes cancer growth.
- It could actually just be one of the many substrates that cancer cells can run on.
- IGF-1 deprivation could lead to failure of other systems in the body.
- The MToR/ AMPk modulation theory is misunderstood.
- Beneficial levels are not super-physiological levels.
- An increase in IGF-1 along with a decrease in IGF binding protein is what is correlated with disease.
- When an increase in both are observed, there is no correlation with disease states.
[20:20] IGF-1’s effect on lipolysis.
- GH shifts mitochondria to aerobic state of utilizing fatty acids.
- The presence of both GH and INF-1 can give a benefit of cleaving triglycerides and clearing them from the blood stream to be oxidized.
- This also inhibits glucose utilization, helping to starve off cancer cells.
- IGF-1 has the ability to have anti-oxidant effects. Just like antioxidants, levels that are too high could possibly promote cancer that already exists.
[35:37] IGF-1 takes burden off of the pancreas to produce insulin.
- Decreases blood sugar by ~ 20%
- 30 days on- one week off.
[38:05] High levels of GH diminish the effect of thyroid hormone.
- Aromatizing androgens increase GH.
[40:16] Renew life prescribes the LR-3 version of IGF-1
- 20 day half-life.
- Displaces glutamic acid group with arginine on the 3rd position in order to bind to protein.
- Dosing is goal dependent.
[43:09] When are levels re-tested after prescribing?.
- 20-30 days after the last injections.
- Dosing frequency: 50mcg everyday for IGF-1 EC.
- First thing a.m.
[45:52] Receptor grade?
- DES is similar to DAC for CJC-1295.
[47:17] If you are already insulin resistant, you are metabolically inflexible.
Real GH secretagogues and IGF-1 will cause anxiety.
