Dr. Sira Karvinen, PhD
A new study shows that in addition to blood, endurance exercise induces changes in sweat biomolecule levels. These findings lay the groundwork for the development of future noninvasive exercise monitoring systems that utilize sweat as a biomarker source. Sweating is an important part of thermoregulation during exercise, yet the potential for sweat as a biomarker source has not been established. Currently, the key limiting steps of using sweat as a biomarker source for exercise monitoring are the low abundance of biomarkers and variation in the volume of sweat in different environments and in different people. PLUS High blood pressure and arterial stiffness is a thing today in young school-aged children. A recent study showed that a very simple exercise intervention can completely reverse this condition.
MicroRNAs in Extracellular Vesicles in Sweat Change in Response to Endurance Exercise https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373804/
School-Based Exercise Intervention Improves Blood Pressure and Parameters of Arterial Stiffness in Children: A Randomized Controlled Trial https://pubmed.ncbi.nlm.nih.gov/32937598/
Show Notes:
[2:40] What research preceded this research on exercise induced secretion of biomarkers in sweat.
[3:45] Micro RNA was the particular biomarker observed.
-mRNA-26 + 5 others were observed.
- very low concentrations.
- Exercise induced higher mRNA secretion than the sauna.
[10:35] Extra cellular vesicles
[11:40] what do the mRNA do in response to exercise?
- Suppress messenger RNA.
- Could be responsible for the epigenetic effects of exercise.
[14:11] What exercise was used?
- Bike ergometer.
- - 5% below anaerobic threshold was the low group.
[24:08] what else could be tested with sweat samples?
- It could be used to test for cystic fibrosis and mental disorders.
[38:56] what do you hope to do in the future with this methodology?
- They are still waiting for the results of further analysis that is being ran.
[51:17] Extra physical activity at school is associated with increased peripheral blood flow and improved blood pressure.
[53:26] Censorship from youtube.
