Timing Your Calorie Load for Weight Loss

[00:05:50]   Alexandra explains why the study was necessary and what work preceded it.

[00:09:00]   Alexandra responds to a question of Carl’s on if it is possible that the state of the microbiome could have an impact on the diurnal effect of calory expenditure observed in the study.

[00:12:00]   Carl follows up with another question about the diurnal phenomenon to which Alexandra responds and then expands the answer to insulin.

[00:15:25]   The discussion concurrently focuses on how the study was designed after which the conversation turns to intermittent fasting.

[00:20:00]   Alexandra clarifies the term isocaloric diet.

[00:21:20]   Alexandra explains the findings in the “morning load” group versus that of the “evening load” group.

[00:22:30]   She goes on to reply to:

• Did you prescribe a specific macro ratio?
• Did you measure any hormones?
• What physiological markers did you measure?

[00:25:30]   The population studied is discussed next with special interest in how females react to diets versus males specifically in terms of the female hormones.

[00:33:20]   Alexandra addresses behavioral changes and responses of both groups within the study.

[00:34:55]   The morning group didn't experience hunger as much, while the evening load group experienced greater hunger throughout the day. Carl wonders if they would last longer if ghrelin was suppressed. Alexandra responds in detail.

[00:38:39]   Alexandra weighs in on fasted training.

[00:40:00]   Carl asks Alexandra’s opinion on the sentiment that “sugar is addictive”. The discussion continues on to food addiction.

[00:43:27]   Follow the conversation on ketogenic diets and the question if low carb dieters experience greater hunger.

[00:52:13]   Alexandra expounds on what she would like both lay people and clinicians to take away from this most recent paper.

[00:53:13]   A riveting discussion ensues on a theory that Carl has on the advantages of eating a bigger meal earlier in the day and finish eating early evening all while still respecting time restricted eating.

Peptide Delivers Protection in Alzheimer’s, Epilepsy

[01:02:55]   After a brief introduction Dr Qin eloquently describes how she discovered this peptide that works on people with Alzheimer’s and seizures.

[01:06:46]   Dr Qin responds to a question of Carl’s on exactly how the peptide works together with an adenosine receptor.

[01:08:29]   Does that also mean that this peptide could be repurposed for a rapid onset sleep pressure drug? Dr Qin replies.

[01:09:35]   Dr Qin elaborates on the half-life of the peptide.

[01:11:10]   The discussion turns to the appropriateness of combining this peptide with others and how it could potentially be a rescue for someone with an ischemic event. After which the conversation covers the topic of Thymosin beta 4.

[01:13:19]   Dr Qin talks about potential negative side effects, if any.

[01:14:55]   Carl follows up with a question about the fact that the peptide is delivered  intranasally and shares his view on the many uses this peptide might have.

[01:15:50]   The name of the peptide is discussed.

[01:16:22]   Dr Qin elaborates on various other subjects she researches in translational neuropharmacology.

[01:18:48]   A remarkably interesting dialogue follows on Alzheimer’s.

[01:20:45]   The interview is concluded with a short conversation on ketogenic diets for Alzheimer patients.