Dr. Irina Conboy
This concise review provides new perspectives on systemic reduction of tissue aging by comparing different strategies, such as heterochronic parabiosis, injections of young blood plasma, neutral blood exchange (NBE) and therapeutic plasma exchange (TPE). Unlike previous literature that primarily discusses the need for young blood factors, we emphasize the potential of diluting age-elevated proteins as the way to re-calibrate systemic proteome to its younger state without donor blood. Furthermore, we introduce modulation of proteome noise, as an important part of understanding tissue aging and as a critical mechanism for tissue rejuvenation. We discuss studies on the dominance of aged systemic milieu in promoting progeric phenotypes in young cells, in vitro, and in multiple tissues of young animals, in vivo. ?️ New to streaming or looking to level up? Check out StreamYard and get $10 discount! ? https://streamyard.com/pal/d/5368881183457280
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Latest Episodes
SHR #3033: The Truth about Glyphosate and Disease
May 02, 2026
SHR #3032: Coming off of GLP one agonist and not putting on a bunch of fat
Apr 14, 2026
SHR #3025: Should You Fear the Fairway?
Feb 21, 2026
SHR #3031: The Sepsis Show
Feb 16, 2026
SHR #3030: Cheating Death
Feb 11, 2026
SHR #3029: The Ultimate Anabolic Steroid Research Guide
Oct 31, 2025
SHR #3028: Slow Aging. Prevent Disease.
Oct 23, 2025
SHR #3026: The Magic of Proper Stress Management
Dec 24, 2023
SHR #3023: The Prime Act - Getting the USDA Out From Your Farmers Way
Sep 19, 2023
SHR #3022: NAD, NMN and NR; Is There Something Safer?
Sep 18, 2023
SHR #3021: The Legend Of Christian Boeving
Sep 17, 2023
SHR #3020: The Sleep Talk
Sep 14, 2023
