Shawn Bean

Having a response from foods or drinks that leads to a flushing or reddening of the skin, changes in sensation and feeling ill may be due to an over-response by your immune system to produce an important compound called histamine. This uncomfortable feeling causes people to avoid those trigger foods and drinks. But what's at the root of this response? And is there anything that can be done to correct this over-response by the immune system? What about supplements that might help?

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Show Notes:

[5:26] Esterone and its effect on histamines in the body.

• There is a high conversion to esterone from TRT in women.
• Could this be due more to long acting test that does not mirror the natural pulsatile nature of hormones in the body?
• DAO enzyme helps to break down histamines. Estrogen lowers this enzyme.
• DAO with a meal can help to lower histaminic reactions.
• The cost of DAO is around 100-120 dollars per month.
• Disbiotic gut is also a major cause of histaminic responses.

[12:05] If you are considering DAO supplementation, give it a trial period to assess if it is working before continuing to buy it.

[13:22] Foods related to hisaminic responses.

• Leaving food in the refrigerator for 24 hours increases histamines (think meal prep).
• This could be from cooking and then cooling and is compounded by the xenoestrogen exposure from storing food in plastic containers.
• Nightshades
• Alcohol
• Fermented foods
• Smoked foods- PAH effect on 4-hydroxyesterone. When consuming smoked foods you are also consuming advanced glycation endproducts as well.
• Shellfish
• Beans
• Chocolate- (from the oxalate content)
• Vinegar
• Beets
• Citrus- Interstitial cystitis is driven by histamines.

[19:50] did we not evolve with wood fired foods?

• This does not necessarily make it healthy.
• These foods can jam up the acetylation pathway.
• They give off aldehydes that require acetylation.
• If you get drunk easily, it could have to do with that N-acetyl transferase pathway.

[22:28] Is there a hermetic response from consuming grilled meat?

[23:47] Acetylaldehyde and hangovers

• Molybdenum association.
• Take 500 mcg after drinking.
• It fuels the NAT pathway and helps glutathione recycle.

[31:05] Are sulfites in red wine the culprit?

• There are products you can buy to convert the sulfites in the red wine.
• Tannins and glyphosate could be contributing as well.

[35:17] The importance of working on SNP’s

• MAL-A breaks down histamine and serotonin.
• Histamines affect multiple pathways.
• MTHFR
• DAO is driven by copper
• Creatine magnesium glycinate can help to support the SAM-E pathway and saves money.
• Creatine also helps to lower homocysteine.

[40:55] Autoimmunity and its correlation to histamine levels.

• Molds cause a histaminic response.
• Heavy metals such as mercury can do the same.

[45:20] Bovine immunoglobulins

• Colostrum?- not for those that are lactose intolerant
• Bovine IG’s help the histaminic issue as well as IBD or Chron’s disease.
• Can be purchased as caps or powders.
• Dextrose can cause a cross histaminic reaction due to its derivation from corn.

[49:22] Histamines and Lyme disease

• There is a rain-barrel effect from histamines. We can handle histamines until they build up too much and cause underlying viruses to be brought to the surface.

[55:55] Caffeine, alcohol, and auto-immunity

• Molybdenum glycinate supplementation can help, but be careful of lowering sulfur levels in the body. Molybdenum and sulfur are antagonistic to each other in the body.

[1:01:10] Certain molds and fungi can convert carbs to alcohol in the gut and intoxicate you.

• A similar genetic disorder called Brewer’s syndrome exists.
• Broccoli seed extract (DIM) can help lower esterone and, thus, histaminic responses.

[1:03:30] DAO sources/ protocols

[1:04:25] Quercetin and coleus forskolii can help with histamines as well.

[1:05:41] Bovine IG’s sources

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Show Transcript

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[00:00:00] I'm telling you. I'm like a monkey. I see my image and I start smiling at it. There's something very very animalistic about that. You see pets looking at the images and mirrors and they get all excited. It's like I know it's just an image of me. But look there I am welcome back to super human radio.

[00:00:48] This is a show I've actually want to do for a very very long time but finding the right person to do it is critical.

[00:00:57] This whole idea of histamines and [00:01:00] diets that elicit histamine response actually was I first witnessed as a very young man in my late teens early 20s when I was at a seafood restaurant and I'm sure my guest Sean Bean when he comes on in a second will in fact Let me let me bring him on now. Let me just do something.

[00:01:25] Hold on Sean. How you doing? Shawn? I'm doing fine thing yourself Karl good. I'm trying to get you on the why is this not working? There we go. That's better. So the whole this whole discussion about histamines actually happened to me as a very young man. Who's at a seafood restaurant in New York?

[00:01:48] And we will all have a good time bunch of us young guys and there was a guy at another table. I didn't know anything about them. He was eating raw clams as all we were you know, that that [00:02:00] would that's a big thing. You're from the East Coast, you know what I mean real clams on the half shell they're fantastic and all of a sudden.

[00:02:07] This guy went into anaphylactic shock. I didn't know it was out of electric shock back then but his lips swelled up. He couldn't breathe and they had to call an ambulance and they rushed him off and I don't know what happened to him. And so we were like, what was that the waiter said some people get a histamine response from eating raw shellfish if they're allergic to them and that's probably what that was and they tucked it away.

[00:02:33] Never thought about it again. And then fast forward to the past decade or two, I start hearing more and more about histamine responses, but not to the degree where they got to rush you off to the hospital. But just to the point where you drink some red wine and all of a sudden your face gets really flush.

[00:02:51] I know a lot of women who are postmenopausal who say, you know, I can't drink red wine anymore when I [00:03:00] drink red wine, I my face gets all red never happened before. And this is in fact a signature of a histamine response. Has it not. That would definitely be a signature of histamine response. But it's also got to do the immunological adaptations that are affecting the gene Expressions that have to deal with histamines when dealing with histamines estrogen is one of the major drivers that helped to precipitate his Dometic responses because a lot of women during their cycle.

[00:03:31] They often tend to have what looks like a little bit histamine levels when it's actually just the rise of the estrogen impacting the enzyme that breaks down histamine. Okay. So when we look I want to dig a Little Deeper now, okay, hold on. So in the case of one of my friends who when she drinks red wine that she gets all red and flush and she said you can't drink red wine anymore.

[00:03:58] Are you saying that's [00:04:00] because. The estrogen is not there to blunt. The histamine response or is the or is the her current low estrogen actually causing an overproduction of histamine. The highest regions are estrogen balance or estrogen dominance. And as you know, we can be estrogen dominance not just from the actual levels, but rather from the metabolites such as the for hydroxy Ester owns.

[00:04:29] And the alteration between the 2 and 16 hydroxy Esther owns. There's so many women that have postmenopausal that they're like why have low estrogen but yeah, but you're also estrogen dominance same time. That's the typical scenario that we see in a lot of these women that have these reactions is that they're low estrogen but they're metabolites are off and this can cause a lot of the somatic responses.

[00:04:55] This is why when working with these type of cases, I always try to recommend [00:05:00] broccoli seed extracts or because it helps to lower the for hydroxy Ester own, which actually the broccoli seed extracts are back door to helping with his demonic reactions of self. Okay. Wait a minute. So now let's talk about a strong for a second.

[00:05:15] This is this is this is how I do things I have a little ADHD. So when you say something that's interesting I go oh I'm like the dog you see the squirrel squirrel squirrel so as drone is in modern HRT practices Esther own is now being called the old woman's or the old lady's hormone a strong is being associated with endometrial thickening and fibroids and so on so.

[00:05:47] It sounds to me like s drone is a big culprit here not necessarily estradiol or estriol it but it's in fact the Astrodome am I correct about that? What happens is we look at metabolic pathways Carl you wanting [00:06:00] to go back and forth and a lot of times it's the conversion of one being pushed the. So the end result is the down she metabolites and as you know, a lot of women are given testosterone replacement therapy via pellets, right and often times.

[00:06:15] We see increased, you know, they may feel good. But next thing, you know, it's like you get multiple cases of you know, you know increased vaginal bleeding and you know, because the what happens with the when you implanted testosterone, it has a higher probability convert into the estrogens estradiol investor-owned.

[00:06:35] And there when they were implanting those pellets, they're not looking at the downstream metabolites, which are a lot genetically are being altered into the wrong path way. Okay, so and I don't want to get too far off into the HRT realm because I want to get back into the histamine diets, but you can't really talk about this without talking about hormonal me lose.

[00:06:58] We know that [00:07:00] long-acting Esters in men of testosterone. Have a higher conversion to estradiol higher aromatization. So if you use a propionate, it has a half-life of a day and a half two days very very little conversion to estradiol and shift all the way up to sippy innate and Aunt date and even Deco Nate as you go to these longer-acting Esters, you see a much more pronounced production of estradiol and.

[00:07:32] And I'm starting to come to the conclusion that it's because the further you go from the natural Polska to nature of testosterone, the greater the deviation of these other hormonal Cascades is that act because now we talk about the pellet which are about six months three months of continuous testosterone and whew.

[00:07:56] And you know, I've seen women's testosterone levels up into [00:08:00] the 250s and 275 ranges for weeks after implementations and narrow their estrogen levels, then they're on multiple creams, but you are absolutely correct. What I've seen in my clinical experiences work with doctors cases, we find that multiple freak, you know, a lot of people are doing EOD injections with lower testosterone and they're finding that.

[00:08:23] Causes a lower it causes a higher trough or causes a higher trough and on a much lower Peak. So you're more getting into a more physiological dosage to where you're not swinging from 300 and you know 300 nanograms three to dekaliter, too. 1600 to 1700 over a two-week period which would missional and what this does is this puts a major stress on the aromatase activity which in males more so in females I've seen associated with his dramatic responses [00:09:00] because as we know that estrogens have to go get broken down at one of those mechanisms that they can affect if not broke it down is called Dao.

[00:09:11] The deal mean enzyme called diamine oxidase is one of the major enzymes that helps us break down histamines alone. So we know that histamines drive estrogens and estrogens drive histamines. So if we rest a ver is to me ever estrogen gets to hide it impacts this enzyme and this makes us more prone to submit responses.

[00:09:34] We are we where are his where histamines produced?

[00:09:39] In the gut they're produced pretty much a lot of them are producing the gut absolutely and food selection has a huge impact on the body's response to histamines as a major source. Okay, so so we know that the immune system is in the gut we know that inflammation is the is the army of the immune [00:10:00] system and it makes sense that histamines would be produced in the gut and this is why I wouldn't.

[00:10:08] People eat certain foods that the response is so fast. I mean it you're not you don't have to digest it hit your gut and all of a sudden you're starting to get that allergic reaction. So that makes sense. You mentioned diamine oxidase. Is that what you said that that actually helps to blunt the his domestic response correct in the person's have what we call histamine and tolerance usually given diamino oxidase with a meal.

[00:10:36] Actually helps to lower. That was my next question. Could you take you take you take Diamond oxidase you can ya Des has are produced by multiple different companies over the counter and are they over the counter type things? We are completely over the counter. Absolutely. They're relatively very expensive and the suggestions that I do from there is a lot of practitioners will [00:11:00] put people on this for nine months at somewhere cost of a hundred hundred twenty dollars per month.

[00:11:05] I normally recommend people get a bottle and then gradually ramp up on them between one to two a day and if you don't get any response don't go any further because they're usually pretty quick when this happens. But as we know going back to the gut one of the major contributing factors of his medic responses in the gut is actually dysbiosis.

[00:11:30] Despite your display out of God will put excess of stress on your body's ability on histamines and a lot of times reducing the and bringing the gut for back in the balance has a huge impact on body's ability to handle histamines appropriately. Okay, so it sounds to me like if you take these diming oxidase.

[00:11:58] Over a period of [00:12:00] time you can stop taking them that I understand that right, but you know, what you do is you give a trial. If you give a trial what happens is that's that's if you are going to respond to them or not. They're not like hydrochloric acid with the body boys using them on her own.

[00:12:17] Right, right. The problem is a lot of practitioners or clients that I run into. I look at them. I look there supplements. I said how long you been on diamino oxidase for like six months? I said do you feel anything? No, that's why you Takin right exactly as we know a lot of practitioner, you know, it put them on supplements and they don't leave most and we're like ppis you do Post you do a post surgery, you know for an elderly person what they do.

[00:12:46] Like, I'm father they put them on ppis gave him like a three-month Supply and they didn't tell me stop. After you know for five weeks after surgery. So here is my father popping, you know ppis [00:13:00] as a protective mechanism which is, you know, fine short term, but he would continue on them for months and that's horrible.

[00:13:08] They're horrible. They've been linked to so many bad outcomes now, it's ridiculous and you can buy them over the counter. Thanks to Larry the Cable Guy. But anyway, So are there certain foods that lend themselves to histamine release that we can pretty much say? Okay, if you are someone sensitive to histamine before we fix your gut before we do that we you need to stop eating these insulting Foods.

[00:13:37] Let me let me bring this up for your listeners other the gym goers and that are the think they're doing wonderful things for preparing their meals. What we found is is after 24 hours. If your food's been liftin, the refrigerator histamines can significantly increase. I have a lot of bodybuilders and fitness competitors.

[00:13:57] I worked with that couldn't lose weight [00:14:00] and in wonder One reasons why when I looked at their genetics, I look at their metabolic pathways and there, you know the actual Gene Expressions. They had histamine intolerance and buy them. Preparing their meals and eating them for five days after they've been cooked because everybody told us as body butters prepare your feet for the week, right?

[00:14:20] Yeah. Yeah, but Sunday's Sundays and Wednesdays days and Wednesdays, but the thing is is if you leave that food and you have a histamine intolerance or in the balance and histamine pathways. 24 hours after that Foods been sitting in the refrigerator your is to meet the demand of the wait a minute.

[00:14:40] Is it is it that is it the cooking and refrigerating or is it the fact that they're storing these things in plastic containers? And and if that if it's the latter are we talking about Zeno histamines now or we talking about you know, because the xenoestrogens and Plastics are we talked about Zeno histamine?

[00:14:59] Well, do you [00:15:00] remember that estrogens increase its emetic responses? So that's a good place blow. That's a good plausible Theory. Okay. I have not seen a kind of data on that yet. I just know that when I recommend when working with bodybuilders and competitors and fitness gym goers. I always tell them listen if you're going to store food in the fridge keep it in glass containers just because the fact of the plastic could potentially leak into the potentially leech, but also try to consume within 24 hours and.

[00:15:31] What I found from the people that are his domestic sensitive depending upon what they store it in. I don't think the estrogens are as big of a supplier is as the food being kept in the refrigerator and not fresh. and so. it really could just be the fact that you're cooking it and leaving it in the fridge.

[00:15:52] It doesn't necessarily have to be the contact of the plastic or do you feel confident that it's the contact of the place? I think it's I think it could be a strong [00:16:00] contributing factors. I just have not seen any kind of research. No one no one's looking at this obviously. Nobody nobody's looking at this but just as safety mechanisms this as you know, my practice I try to cover all bases try called our basis so that we don't leave any kind of variable out that could be.

[00:16:21] Yeah, now makes perfect sense. So but now let's talk about let's talk about food categories as well. So do can we can we say things like well nightshades seem to precipitate a greater histamine response in people who are sensitive to histamine. That could be yes Tomatoes nightshades, but we also have two categories such as alcohol fermented foods such as if you're doing twofer kimchi.

[00:16:49] And preparing those fermented foods that are really really good for the gut. They are also extremely high for histamines to and if you have dysbiosis on top of that [00:17:00] you're you know, you're getting a added insult. Another mechanisms are a lot of people like smoked Foods. Okay smoked salmon. I don't eat.

[00:17:09] I don't eat smoked Foods anymore, you know why simple critical thinking there is particulate matter. Embedded in that flesh. I don't want to eat the wood. I don't want to eat the burning wood. I don't want to eat the burning wood into my meat. And that would be a great that's from the pah. Is that actually stress the for hydroxy Esther own which makes people in predisposition to estrogen dominance another Factor side barring from that is.

[00:17:39] People that love to cook on grills and they hear that, you know, as soon as you cooked that steak and hear that everybody goes. Yay. That's actually carcinogenic. That's alternating your for hydroxy extra. Are we also when we talk about smoked foods and we talk about high heat cooking are we actually [00:18:00] ingesting AG he's at that point in time, aren't we literally mainlining Advanced glycation end products from that heat process or in the case of smoked Foods?

[00:18:09] Those particles of smoke that actually be embedded. Those are AG. He's too right? Absolutely, they could be classified them then on top of that with smoked Foods. You got the increases to means. Okay. The other one you mentioned was also shellfish. Another classification is beans legumes really but they're so healthy, but they're so healthy for you and then you've got the then you have girl's best friend.

[00:18:38] Chocolate is one of the major histamine not just histamines, but also oxalic foods that you deal with vinegar is another one and then our Nemesis sweet tomatoes and also Citrus maybe another. challenge 2 but when we talk about citrus can we tease out the chemical influences [00:19:00] in conventional Agriculture and the actual intrinsic effects of a citrus fruit or we can't really.

[00:19:08] Really can't because if you have a female that's got Interstitial cystitis, and they take and a lot of that stuff is driven by histamines by controlling the histamines you actually control the Interstitial cystitis. So any kind of citrus may be irritating to this enzyme whether its natural or unnatural occurring say more with tomatoes tomatoes are natural occurring and they have histamines to so it just as.

[00:19:37] As default I remove all those Foods out of the persons or just decrease them and then eventually removed them out of the diet just to see how people respond. Jasonlew says something. He says a question. He says we evolved with food with Wood-Fired Foods know until we could Forge steel and had pipe gas, but that doesn't make it [00:20:00] good for us.

[00:20:01] There's the you know, there's a large movement of raw food eaters. I did shows a tech a decade ago. With Josh Trenton and Randy Roach talking about raw food eating and eating raw meat, you know, there are a lot of things that we have done look at the 40,000 year ago decision to start an agricultural environment where we would grow stuff and save it all year long which really didn't work.

[00:20:27] Well, but my point is just because that's what we had doesn't mean it's good for the human. No, and he brings up a valid point and show to you is you know, when I sit in my fireplace, I have fire and I have with but unfortunately because of my genetic pathway my acetylation pathway gets jammed up those off-gassing from the would even though it's natural from the you know outside.

[00:20:56] That's still clogs up my system and can still [00:21:00] over burden the. Oh, we have a frozen camera. Thank you wireless internet. There we go. He's coming back now. Can you hear me so bait? Yeah, I can hear you good. Okay, good so base. What I was saying is even though that we're you know, we sit by the fireplace in our houses burning wood that's given off aldehyde and aldehydes have to go through the n80 pathway with his ego simulation Pathway to get broken down.

[00:21:30] And acetylation pathway is one of the main factors by which you are breaking down is to means as I alluded to a mutual Mutual. client of ours, so to speak I refer to as the n80 pathway as the drunky pants jeans because as soon as saw that pathway being highly literate. I ask the questions. I said you 10 get drunk very easily on alcohol [00:22:00] and they female responded Yes.

[00:22:02] I do. You know, I can't drink alcohol like you used to and that's one of the pathways that gets backed up through there. So alcohol impacts that n80 pathway which also increases the demand or reduces the body's ability to take care of this means in the first place. Let's answer this other question from Darcy Clark.

[00:22:21] He says he seems to remember reading somewhere. That there's a hormetic response to grilling meat any thoughts on that, but see hormesis implies that we develop a benefit. Right. I mean II don't know that there is anything beneficial about grilling meat except that it's socially unacceptable and it's hygienically a problem to eat raw meat today unless you are killing the animals yourself, but what you really there's a hormetic effect to grilling.

[00:22:55] I don't have the expertise to comment on that at all. Yeah, so [00:23:00] what I would say is if you're grilling in general, you are increasing carcinogenic, you know, you're increasing carcinogenic exposure, which has been proven and you all are stressing and potentially putting your see why P1 V1 gene expression on demand, which goes for the for hydroxy Ester own pathway.

[00:23:21] So and we know that for hydroxy Ester own is the one that is the major. Problematic one in regards to the DNA. We once thought the two and 16 hydroxy where the major contributors that's not turning out to be so true anymore. It's the for hydroxy that has a stronger of the DNA change. Let's let's talk about this and they're going to take a break acetaldehyde is the culprit that is blamed for alcohols effects on the brain and also the effects on.

[00:23:52] Feeling hungover the next day it is that in fact true. Is that the acetyl alcohol and doesn't L [00:24:00] acetyl-l-carnitine have the ability to kind of quench that and keep you from getting hung over. The Hangover the hangover cure The Hangover core is associated with that one mineral called Melinda. Will lead them was discovered by that the result of molybdenum was discovered Accidentally In my own experience for the hangover cure was when my wife decided to go on her back to a party and now as a result of that she carries molybdenum everywhere.

[00:24:37] She goes she goes out partying. Because what happens is they found that if you take molybdenum, it actually is one of the cofactors for the alcohol dehydrogenase pathway, and we always joke about being the hangover cure and I think I mentioned this to her mutual person yet during our consult [00:25:00] is yeah, you can take molybdenum.

[00:25:03] After you get done drinking and I even gave it to a guy out of the bar who was stoned drunk who had couldn't even walk and was trying to drive home. I said take about 500 micrograms to 1 million because that's that's a metal. Is it not a metal? Well, what it does is it's one of the major cofactors for the it's a trace mineral.

[00:25:27] Yes. Which our body requires a certain amount and it works on the n80 pathway is broken down by Fineman, which is B1. It's broken down by B5 which is kinds of thetic accidents also supports pathway is live in them, but I found that when you have that hangover molybdenum is probably the best hangover core and also if you can get your hands on glutathione.

[00:25:53] And you're able to tolerate it glutathione also helps to push the alcohol Fallout 4. There's people who [00:26:00] can handle it appropriately entering the room and the molybdenum actually helps the glutathione recycle itself. So it stays in its proper form because a lot of the times you've dealing with, you know, if you drink wine you're dealing with sulfur you're doing the sulfur.

[00:26:16] Well, if you're molybdenum deficient, you're not going to break down sulfur. In whether it comes from broccoli cauliflower leaks onions garlic and this is going back to that Infamous CBS pathway. We talked about and believe it or not the 1080p pathway and the CBS pathway are directly interconnected through molybdenum.

[00:26:36] So by taking care of the NTT pathway you we actually would see a simulation pathway. You actually addressed this sulfation pathway in the process and the link to that is the molybdenum and this has been a tried and true. Experiments because I've actually given molybdenum to people who were drinking and they noticed they had to drink considerably more to get a buzz.

[00:27:00] [00:27:00] This is really interesting. We're going to take a quick commercial break when we come back. We're going to talk more about the histamine response and will also list all the things that you think people who have an unusual histamine response need. Look at both supplemental and as well as their own physiology, we'll talk about that as we get a little bit further into the show stay tuned.

[00:27:21] We'll be right back with more superhuman radio. So we have a very funny exchange happening in the audience here. People are suggesting that just don't stop drinking. Jason Lulu said I was told to just stay drunk and you don't have to deal with it meaning a hangover. And of course Darcy Clark thinks that's hilarious.

[00:27:45] And Jason Lulu is actually watching the show in between doing Farmers walks with a portable generator during the commercial breaks. We´ll, we are going to have more commercial breaks now just for you Jason so that you could do more Farmers walks. You know, I love Farmers [00:28:00] walks Okay, so. Is it is it is it the sulfates in the wine that caused the his domestic response to red wine?

[00:28:09] Because there's women who can drink red wine all day long and get nothing, but they drink red wine and they get hit. You also have to consider about the quality of the wine. A lot of people there's low sulfites and then I just got back from a conference and I just made everybody today. There's actually products out there that you can get at your local alcohol store where they sell wine that actually deactivates the sulfites really really, how does it do that?

[00:28:43] It's somehow changes it to some inert form. I learned about this trick from a colleague of mine from Australia. When I look at the ingredients. I think the one that she was taken was just food grade hydrogen [00:29:00] peroxide and somehow converts the sulfite into a hydrogen sulfide. Was it into some kind of hydrogen sulfate gas?

[00:29:11] So it's kind of like Burns it off, but the ones that we use their like little tiny ones that you dip into the wine and it removes a soul fights out of it. So so is so is it is it so are the sulfites? In fact the culprits is that why women can drink white wine, but not red wine. They put sulfites and white wine.

[00:29:30] I don't even know I don't I'm not familiar that they do. I know I really want but. You also have to remember too is is the red wine. Also, you know, there aren't a lot of whoa. Yeah cannons, you've got you know glyphosate. It's now that are found in a lot of wines because you know being sprayed so that's why I always every maybe go to the wine store.

[00:29:57] I always recommend organic. [00:30:00] Yes will face a little. Impossible and there's plenty of there's plenty of organic wines out there. In fact, they started out being some table wines for nine to thirteen dollars a bottle that are organic but now Gingrich Hills, which is a leader in fine wine has an organic wine line that they're producing and Gingrich Hills is a very very expensive wine.

[00:30:22] So it more and more people are getting it listen. Wait a minute wrong question people asking questions faster than I can get to them here. So. where the heck did it go? Darcy Clark had a question about MTHFR. Here. It is. Here. It is here is let's get this up there. So he wants to know what you think about the importance of working on one's SN Snips like the MTHFR Dao Mao and others how important those are in this discussion.

[00:30:58] Wireless internet. [00:31:00] we'll wait for him to come back. You just I don't know if you can hear me, but your camera has frozen. Let's give Darcy a minute. Well Darcy, I don't know if we're going to get your questions answered because I feel like we may have lost. Yeah, he'll have to reconnect. Let's just sit tight.

[00:31:16] We'll get this question answered. He'll just reconnect. Let me text him and tell him to. This is a this is what you see here is what I try not to do wireless. But the reality is it's a it's a everybody's got wireless internet today and very few people have ethernet and sometimes I'll say look we need to eat the Net Connection to like I don't have one.

[00:31:43] So let's just see if he can reconnect real quick. But this is a good question. I have a feeling he's going to say it's very important. I think that's what he's primary role is in. His practice is to look at people's Snips and then [00:32:00] decipher what they have a propensity for here. He comes here he comes here he comes let's add them right to the broadcast and I'm right back.

[00:32:07] We'll just pick up. Well, hold on a. Sean will just pick up where we left off Shawn and you're on the other side now this that's fine. So, what do you think are those those Snips important? That's really the basis of your practice. Right? Don't you interpret those things for people and say, you know, you have a propensity for this.

[00:32:25] Yeah, the mayor the mount a it would be not the mouth be but male what happens is this means get broken down by male and also the same mechanism that breaks down histamines also break down. So if you have excess of histamines, you're not going to be your serotonin metabolism is going to be off to that's why we see a lot of autistic kids with high levels of five hiaa in their urine because they have excess amount of histamines to where it can't break it down properly.

[00:32:52] So absolutely it's means the serotonin have a direct relationship his means and also dad can [00:33:00] also be a problem histamines and comp can be a problem because histamines also increase epinephrine norepinephrine. Which are necessary for the community broken down pathway, which has to do the catecholamine pathway histamines.

[00:33:15] Also go through the Gad which is the gluten no glutamate dad pathway. So yeah, it's means can be a really major biochemical disruptor on multiple Pathways MTHFR again. You want to think about you want to not get in that? Caveat to where we get trapped into. Oh my God, MTHFR gotta pull yourself back and look at the big picture.

[00:33:44] The bigger picture would be of methylations methylation status in general and a lot of people's methylation systems are impaired because of response because they're actually down regulated as a response to a cell dangerous Ponce as a protective mechanism. So [00:34:00] sometimes methylation is actually low.

[00:34:03] It's trying to tell us something that hey. If I push glutathione is going to go into its oxidized form and not get recycled. So whenever but whenever have a complex medical case, I put a kibosh on the methylation and just work on for support system because I found that through years and years working with complex cases when everybody was pushing methylation system.

[00:34:25] I was the one to go against the grain and say guys we got to stop this and after about seven years that has been the current. That we're starting to see where methylation needs to be supported and not pushed and also methylation is one of the mechanism by which comped breaks down the histamines and we know that Sammy can be a positive and a negative thing.

[00:34:54] It can either increase the problem or connect at breaking down the problem [00:35:00] and then with the Dow. The Dow is driven by the mineral copper. So now you try you mean the gout is excessive cop or not enough Dow J. Oh, I'm sorry. That's why I mean Stacy cofactor is copper and a lot of times we have copper imbalances, which means we could have an excess at the tissue deficiency at the blood for multiple reasons, and I'm sure you can have a whole show on just that alone will complement ablism.

[00:35:31] But a lot of people were oh my God MTHFR no, look at the methylation and one of the best ways you can support the Sammy cycle without adding insult is to use creatine creatine not monohydrate, but creatin founded by phosphate. Phosphate would be good, but it creates [00:36:00] in the one that's bounded by the Magnum creatine bounded by magnesium glycinate works very well.

[00:36:09] And what that does is 70% of creatine's function its produce Sammy 30% is produced phospholipids. So we have a person has a cop Gene. Then what I'll do is is I will hesitate about going to Sammy right away and I'll use Krypton and phospholipids to conserve the Sammy and nine times out of ten the saves people money because Sammy is very expensive and it saves a lot of people having to have negative responses.

[00:36:47] Creatine has an a creatine has an intrinsic value and that is that creatine is produced in the body and it spins off. What's that inflammatory marker [00:37:00] almost it's been published and I was like I had his I had histamine stuck in my brain. I'm like no no no and it spins off homocysteine. So by taking creatine your body doesn't have to produce creatine and homocysteine levels drop and people they'll go to the doctor.

[00:37:14] So my doctor said my homocysteine levels are high that's an independent market for heart disease. Take B12 take B6. No, no take creatine, and you won't have any histamine anymore because your body won't need to produce creatine anymore. Exactly simple stuff right Sean simple stuff goes a long way foundational, you know without the minerals these enzymes and Koufax these enzymes have Pathways just don't work.

[00:37:40] So so let's let's talk about something else when we talk about histamine, right? We live in a world today. Where everybody? Has an auto immunity, I mean most of the diseases we see today rheumatoid arthritis even now [00:38:00] even osteoarthritis is being attributed to an auto immunity. Not not to Mechanical loading of the of the skeletal system and when we talk about autoimmunity.

[00:38:12] We talked about an immune system that is stop serving us and start as thought it to hurt us. Could this. Excessive histamine response be one of the like the canary in the coal. Mine that autoimmunity is just up the road now. We have to look at the factors that actually trigger the Mast Cell Activation itself.

[00:38:34] And when we look at histamine, we have to look at how it's released and how the body detoxifies it. What are your starting to see Carla's your shoe starting to see the environmental impact specifically mold. Is one of the biggest Nemesis in his domestic response has a lot of people once I get them out of the mold and clear the system of mold support their semantic responses.

[00:38:56] There are massive Cell Activation or [00:39:00] MCAS massification just syndrome stops or decreases, so. We have to look at no heavy metals also can drive a piston mean Mercury is a major one that drives the Piston amalgam fillings amalgam fillings, while them throw, you know, you know, you know, you know, what all of this is.

[00:39:19] So when you're when you're in reproductive age, the body is amazing at overcoming the challenges. I mean, it's like it's like the guy on The Ed Sullivan Show spinning plates got them all going. It's great. As you start to age these think could this is why people say well I used to be able to eat that.

[00:39:39] Well, I never used to get that response when I drank that it's because your body is now reaching a point where these things that your body was doing a really good job at managing. It just can't manage them all all anymore that the truth is that never could manage them, but the body has a way of holding its stuff together.

[00:39:59] Through the [00:40:00] reproductive ages because that's what our job is to have babies and die and so reality is you're laughing but it's true right? I mean forget about Maslow of and his theory of hierarchy with supposed to be born have babies died in that order. Those are those are the those are the cellular edicts for her body.

[00:40:18] And so the reality is that most of these people who are starting to develop symptoms their bodies have been under siege. From an immune response for a long time, but the body has been able to handle it, right? And that's a really good point because what happens is I refer to as a straw that breaks the camel's back and that's when that gene expression starts to happen that expression could be I mean vaccination during a system for clinically sometimes up to several decades.

[00:40:48] I don't know the exact studies, but I have sold even one person. Suggest that has been 40 years that vaccinations can stay in our system. [00:41:00] We have mercury fillings that would put her in a mouse that have been decaying over time causing problems. So, you know, our environmental and soul is probably one of the biggest concerning factors, they submitted responses and then along with all the his environmental responses.

[00:41:16] All those environmental responses are just going to wreak havoc on your gut. I mean if you got glyphosate is coming in if you got these other end options toxins, your LPS is are going to be increases you to put the polysaccharides are going to increase that's going to open up the door by increasing zhan Yuan levels sodium levels and increase opening up the door to intestinal permeability and then use become with one big vicious cycle where you've got the environmental toxins feeding the bugs then the bugs turn back and.

[00:41:48] Prevent the body from returning back to homeostasis. That's why one of the biggest factors that I use in his domestic responses in that have been clinical research [00:42:00] is bovine immunoglobulins serum bovine immunoglobulins actually bind to the antigen within the GI tract and contains the food contains the immunological response food for the pathogens, so it doesn't get to the.

[00:42:15] Systemic response to activate the mast cells. So bovine immunoglobulins have been phenomenal in containing the blow those bovine immunoglobulins has also been shown in clinical studies from endurance Runners to actually lowers danial levels. Wow, so and we talked about what I've been a good high quality colostrum.

[00:42:39] Well, you're comparing apples and oranges what happens with the colostrum is is colostrum contains a lot of the classroom is not good for people to have lactose intolerance or even casein the bowl. What immunoglobulins are directly derived from bovine, which is Tau. So this way there's no allergic reactions [00:43:00] than Studies have been shown my wife who's a nurse practice nurse practitioner.

[00:43:04] Who's my wife did her. Thesis on bovine immunoglobulins and how they work on Crohn's colitis IBD. I even have a reported antidotal evidence from immunological responses from gluten that got resolved within 30 to 60 Minutes of having me as other so well, these are these capsules are they in is this an injection?

[00:43:26] How do you take bovine immunoglobulins? But what a terrible way to go there they come. They're powder their capsules that cannot be injected as of now, but there are very respectable Brands out there that are good that are currently being researched. The medical drug are the medical food has a component as a product from a drug company called tarragon.

[00:43:59] [00:44:00] Enteragam is bovine immunoglobulins and territories that are actually coded I would imagine right? No, they're in the powder form. There are the only problem is that contain some flour like the thin which is non-GMO, which is GMO modified of course, and I think the contain dextrose which I found dextrose actually comes from corn.

[00:44:21] Which can be a problem people have cross-reactivity the corn. All right, I found that in one case and once I switch them over to the bovine immunoglobulins that a company actually paired with the natural company actually compared orthomolecular actually combined with the drum companies to have the rights to provide the raw material for the actual same stuff that use enteragam.

[00:44:51] They have a protocol SBI protect. That's really good and also microbiome has a really good product out. [00:45:00] That works very well. I believe it's Mega igd 2000s Studies have shown anywhere between two and a half grams to 5 grams up to 10 grams can be beneficial. It doesn't matter how or when it's taken.

[00:45:17] To be to be therapeutic use but these have been these will probably be the stable and next five or ten years for cases of dealing with IBD Crohn's. I've got a couple people now that are doing bovine immunoglobulins with PCP and 157. To try to help heal the mucosal barrier from those conditions.

[00:45:41] You've got to add LL if you've got to add LL 3 7 to this discussion because LL 47, so I used to get very red on my chest. Well Redskin, this is what my gut was. It's worse. I had a distended stomach everything. I ate bloated me and I used to get very very red on my chest. I've done two cycles [00:46:00] of LL 3 7 the redness is now just up here, but it's almost all gone.

[00:46:05] My stomach is completely changed. I have a funny feeling that that this would benefit a lot of people. I want to ask you one other question before we take our next break and that is I had been errands on the show earlier this week and he. Was diagnosed with both multiple sclerosis, and eventually it was Lyme disease and he grew up in Long Island and it all makes do you know?

[00:46:28] No, but I know the sequence I see I see it all the time. Okay. So let's go back to the histamine response for a second are these people who develop a quick because we established during that show that there are people out there who have the lime virus but they never they never have any symptoms.

[00:46:46] So clearly their immune system is a capable of keeping it in check. So is there is there some sort of. Common Thread with people who seem to have a hist emetic response and then eventually developing Lyme [00:47:00] disease. That's a really good point again, as you mentioned the immune system is like a cage.

[00:47:09] It keeps the virus especially EBV Epstein-Barr lime: factions contained because we've been with these organisms and limit symbiotic for millions of years data has shown. And it's like all sudden. It's like why are we having problems? You know, it's because our immune system which has which has a lock on it is actually getting arrested and it's allowing these organisms to express and with histamines.

[00:47:40] What happens is it's just a it's a building up over time until you come to the straw that breaks the camel's back. So people can probably hit be able to handle his means but they are. Insta means Drive inflammation and we know that inflammation drives Gene expressions. And then once that once that combination of that hard [00:48:00] drive as I refer to and you have that virus on that hard drive, which is a Trojan.

[00:48:06] Once that Trojan comes awake and it brings all these viruses and things up to the surface that were there originally, but our body was keeping in check as Mother Nature intended to be. So yeah, there's anything that impacts the immune system. Inflammation is going to affect a person's gene expression and Implement.

[00:48:28] If you know, I find it interesting that so many clinicians will talk about how inflammation is is the basis of many diseases and but they don't correlate that to say the immune system is the basis of many diseases and that's because. The inflammation is the army of the immune system. If you have chronic inflammation, it's because your immune system is having problems.

[00:48:54] We just lost the bet we just lost Sean again, but we'll get him back on we're gonna run a [00:49:00] commercial break anyway, so this works out perfect. Stay tuned. We got more be right back. We're back in the right order now. We're having some internet connectivity problem, but that's okay. It's not stopping this.

[00:49:13] So my friend Paula Giordano who I grew up with said that his skin turns red with any alcohol consumption. And so maybe it's not just the and you know alcohol is being implicated in being a really bad actor along with caffeine in autoimmunity. Have you read any of this literature that shows an alcohol and caffeine seem to be they seem to exacerbate autoimmunity in.

[00:49:42] Yeah, I mean captain in general can be a positive thing. But if you lack the body's ability to break it down, it can be go pro-inflammatory pretty quickly and the same with alcohol too. If you lack the enzymes that break down alcohol. It becomes problem farmers were [00:50:00] re-released in Chrome from Tori cytokines.

[00:50:01] And this is what we know what the Millennium the Millennium olivarium. How do you even pronounce it? I don't even try that that that's where that would come in. Right because it enhances that dehydrogenase enzyme to help break down. Correct. One of the interesting factors added measuring that a lot of doctors don't matter is they actually have LabCorp as molybdenum levels RBC.

[00:50:23] And 90% of the population that I test just in general are coming up less than DL Which is less than detectable levels. So what does that tell you because I thought it was a fluke, but then I started seeing then I started testing other people and I started say wait a second. They're actually having learned certain levels in there that are not high, but they're showing their markers are showing up.

[00:50:46] So molybdenum is one of the levels that a lot of people are in testing and is soon to see load molybdenum levels. I know that this problem has this probably probably has a gene expression on n80 gene expression [00:51:00] which has to do with the seat allow the hides which is indication from old a lot of people that have because you know acetyl aldehydes, you know is what breaks down not just your yeast.

[00:51:11] But also your fungus to and also your mold issue, SOL, SOL, SOL. SOL. Are there any so on I want to talk about solutions for saying so are there any good sources of Millennium Mala? Barium, how you pronounce it better than I do. You know what I'm talking about? Yeah source of molybdenum actually are one of the best resources military and get is actually in beans itself is a natural source.

[00:51:41] Gene's have the high source of melindam in the supplemental wise I usually recommend molybdenum glistening glycinate, which is very very good. There's products from multiple companies that have magnesium glycinate. You just got to be careful because if you have low [00:52:00] sulfur molybdenum will actually cause your sulfur to lower even lower even down.

[00:52:07] So you have people that are. It's like people that take MSM or high sulfur. I normally look on there. You know, I'm not a big fan hair analysis testing, but I do use it for some of the markers that show maybe like a celebration pathway and balance that you'll see Sulphur higher and molybdenum lower and then if that's true, I'll go and cross-reference it with like red blood cell melindam on LabCorp or look at whole blood.

[00:52:33] So. And you can you know, there are cases where I actually had melindam toxicity were people taking excess amounts of molybdenum from poor practitioner because they are trying to deal with the candida because what happens is in the metabolic pathway molybdenum comes Earthsea acetaldehyde into acetic acid.

[00:52:54] If you have if you convert into acetic acid what that does is it allows the body [00:53:00] to take a toxin and move it into Krebs cycle. Which can be very very beneficial for brain fog. There was an awesome article written by I think it was Cooter's Corner many many moons ago back in like nineteen late 1990s early 2000s and they actually had people that candida that were taken with them throughout the daytime and they did just an anecdotal and they saw significant improvements and mental quality.

[00:53:31] Energy-wise about you know what? I don't think I don't think so. I don't think it was just the candida. So people who have infested guts. They have certain types of molds that produce alcohol from sugar that they consume. I heard a story about five years ago, and I believe that immediately a woman was stopped by a police officer.

[00:53:55] She was driving, you know this story. We should driving erratically there was an article about it [00:54:00] and they she know she blew like a she blew like a 1.8 that the guys like you've been up she goes. I don't drink I don't drink alcohol at all. She goes. So they had to take her to the doctor and they proved that she was kept in a ward a metabolic Ward for three days.

[00:54:16] No alcohol, and she was blowing like 1.6 and they realized that she was so infested with this particular fungus. This mold that it was actually converting sugars to alcohol in her body and she was drunk without realizing it right. That's why it's called when you have candida I called. Shit, we lost them again.

[00:54:38] Oh, I cursed. I'm sorry. I shouldn't have your size. It's called White repeat that it's called a lot. But Brewers syndrome brute. Okay, like like, you know you feel drunk. But again that could be from multiple different factors. There's one case I worked on several years ago. That the that blood [00:55:00] alcohol content was so high that they thought she was an alcoholic and she actually lack the enzyme.

[00:55:05] She actually had a gene deletion in the enzyme that breaks down alcohol and body was manufacturing and it wasn't getting rid of any of it either. It was coming from the carbohydrates because carbohydrates can be broken down to the acetaldehyde pathway and she lacked the, you know, she'll actually lack the enzyme and she actually was.

[00:55:25] Almost blood tox. He was almost sepsis as a result of it and nobody can figure it out and she went to every single doctor on the face of the Earth. And I said no I want you to go to this go to this Hospital get your blood level check and her blood level was dangerously high and then they had to work on you know, they had the.

[00:55:48] Dad switch out your diet to now that would be a ketogenic diet that probably would have to be lifetime for right because she has International genetically medically. Well exactly. [00:56:00] So let's talk real quick about recap why someone would take broccoli seed extract if they wanted to lower estrogen levels, correct?

[00:56:11] Correct. There have been anecdotal evidence from. That have been seen from dr. Carey Jones from Precision hormones as well as my other colleagues that using the broccoli seed extract has helped with major systemic responses. I have actually actually have with allergies in. In general, yeah, exactly and kind of allergic reaction.

[00:56:39] So it's a back door to the Dao. It actually supports the DL enzyme. We don't know what mechanism yet. We're still looking on that pathway. It probably got to do something with Nerf to because I breathe I believe broccoli seed extract increases nerve to and Nerf to has profound effects on every single biological system.

[00:56:57] There is nobody and we're still learning [00:57:00] about it the other one the other the other things that you talked about were. I can't think of those the hydrogenation. Yeah, the actual the actual enzyme called di Bao enzyme there's several companies out there that make it one company is seeking Health another another company that had was Swanson had them and if people have his immune responses that are unexplainable from food.

[00:57:27] I'll have them try out trial. Of I said just get one bottle. If after one bottle you don't feel anything that's not your problem and can radically if you know, you you drink red wine and you get a response with the red face, then you would take one or both of these water half hour before going out drinking.

[00:57:45] Yeah. Yeah. Absolutely. It's a trial experiment, you know, there's no absolutes, but normally with the molybdenum. Would be a preventive if you have a hangover, it will be done afterwards. Okay? Okay. And [00:58:00] what about what about quercetin quercetin seems to be showing up as something that helps to slow down the immune response over responsiveness.

[00:58:11] If you're going to take one supplement that's going to help with quote Master activation or his men of responses quercetin will probably the top of the chain. There's another one that a lot of people don't know about that. It's that's actually hit. Research that I found is Coleus Scott: yeah coleus has been that actually shuts down that actually reduces the activation of the mast cell.

[00:58:36] I found that in clinical studies, you know, coleus coleus is Coleus makes people lose weight fast what they don't realize is. That coleus shuts off the immune systems response to inflammation which shuts off edema which makes you urinate out like six pounds in one week and people go. Oh my God coleus is the greatest fat loss product in the world, except it stopped working after the first week.

[00:58:59] I don't understand that. [00:59:00] It's because it wouldn't make you lose body fat and make you urinate all the edema quarter-- out of your body. So it's so funny. I know coleus comes coleus was first touted as the great diet product. Now, we know it's really good for information what happened? So and the last one I want to recap on is the bovine immunoglobulins.

[00:59:20] This is a this is an isolate. This is not a dairy based, you know colostrum type thing. You'll talk about isolated bovine immunoglobulins people can buy, correct. And companies that produce that or that black bear and there's an also a company that I ran into called microbiome microbiome as the manufacturer of megaspore probiotic and that works very very well.

[00:59:50] I do love myself, right? I do that myself and I've used it with clients and if you're going after any kind of gut dysbiosis, That would be my first line of [01:00:00] defense is to contain the veloz of the immune system does not get out to the systemic inflammatory responses in the body and by doing so what that does is allows other attempts on the it allows the other attempts to deal with the die-off more effectively and reduce the stress on the body because if you if you reduce stress with Anna Gunn, It's going to go out.

[01:00:26] It's going to reduce stress on the HPT access, right? It's what every doctor. Yeah, so in summary in this hyper allergic tendency to develop autoimmunity population we have today. It sounds to me from a prophylactic standpoint. Some are all of these supplements. We just listed would be good choices for people to take who have periodic allergic responses whether they manifest that.

[01:00:54] Atopic dermatitis or eczema stuffy nose [01:01:00] watery eyes, or just some of these other issues like Redskin or so on. It. Sounds like we live in a world today that is mismatched for us. And so most people have some sort of allergic reaction sounds like these supplements. We just listed would be good for anyone to know about.

[01:01:18] Yeah, they would and they're the reason I like these supplements that I suggested they're pretty benign so they won't really caught.

[01:01:29] Boy from The Comeback stay with me. There you go. So you you dropped out right at pretty benign. You lost your internet connection start from pretty benign and go forward. These products are pre 9 so they're not going to cause a major reaction with people and. One of her first, you know our first priority as practitioner is this safety because there's too many people throwing a lot of stuff at the wall to see what sticks right and taking calibrated approach but one of the first things I advocate and to all your [01:02:00] listeners is think about the foundational stuff.

[01:02:02] Things you can do first just you know, your water source is changing the making sure you're you know, I have people that have I have people that are drink plenty of I drink water but they're drinking out of a bottle of water, you know, you switch them over to Mountain value spring water and then all the sudden they're like, oh my God, I'm getting reaction from everything.

[01:02:22] It's like well have you looked where you located that? You know squirt art score.org shows you where you're located that tells you what kind of walk through the right Harry of right exactly. Right? Even if it's even it's been 2002. It gives you somewhat of an education. So, you know, you're you're doing great with the water.

[01:02:39] I had a client of the day you're doing great with the water, but you're still having X mama. What about your shower filter? Do you got to think about the shower filter? Then he got to think about your home, you know, you cannot heal and then toxic environment. It just does not work. So we have mold you don't can't get rid of it.

[01:02:56] Then you want to think about getting you know in the Specter in [01:03:00] there, but you know with my clients have multimillion-dollar houses. They're like Sean. I'm like, I'm not going to be $200,000 renovation to a house. So there's things that you can do by using different mold machines that I have in my house because I you know, if I don't have that mold machine running my Asperger's and my hysteretic responses go crazy my part 1 by I start running if I don't have the most machines run of IV if I use the fireplace or that or this filters need changing.

[01:03:31] You know, I run the fireplace my eyes start watering all I got to do the next day. I look at the filters like oh crap, you know from the vocs from the burning that it was time to get times that it has to get changed. Right? So I advocate the things that I do my clients and because you know, you have to practice what you preach and we can only do what we can but your house and your environment.

[01:04:00] [01:04:00] Pass to be safe. Otherwise, you're not going to heal. Even your workplace is I have clients and stuff that are having his medic responses after they freaking work out well upon further evaluations the gym that their training at exactly the gym. Their training was Jim Kim have gives a funky funky places man.

[01:04:21] They're dirty places. I mean most gyms a dirty. Even the ones that they have someone going around cleaning. They're still dirty, you know. Well, yeah from the aldehyde from the perfumes or cleaning, you know, if you get a competitor that's can't lose weight and all sudden they leave the state and they get better said, you know, you're you're training your training and working and infested area, right?

[01:04:44] And as soon as they get to like showing why am I cleaning out? Why am I losing water? I haven't I'm not doing anything different. I just live someplace different, right? All right, love someplace someplace different. So the only thing you got to do is. You know instead of spending all this money on [01:05:00] practitioners do things simple first.

[01:05:02] I always tell a client if you're having aesthetic responses and you're always constantly inside change your environment go on a vacation get out to maintain that going on vacation Sean. I feel so much better. I said well your kids came with you. So your stress levels are still there to some degree but your environment changed.

[01:05:22] So these are people that have been either people been to doctors at the doctors at the doctor's all these protocols and stuff when I say take a vacation. Let's plug your website first. It is Matrix Health well.com. Correct. So people can go there and connect with you if they have questions that have been inspired by this interview.

[01:05:43] They want help you can help them. I know you work with people on a distance basis. So that's what the start to reach out to Sean Bean. Jasonlew made a comment. I want to keep it up there for second clearly filtered. We have a special discount for clearly filter. Do you go to [01:06:00] superhuman radio dotnet and click the clearly filtered Banner ad you can take advantage of it.

[01:06:04] They have everything from shower filters. Pitcher filtered their picture filter was compared to what's the one that advertises on on TV all the time. I can't think of it like a sauna. No, there's another one a picture filter, but they put their picture filter up against a bunch of other ones and they used just a simple die.

[01:06:26] And the only one that actually got everything out was the clearly filtered. It's the best pitcher filter in the world. So check that out and last thing I want to mention. Right. Now you can enter to win a set of five to fifty pound per hand Quick Change dumbbells from PowerBlock go to superhuman radio dotnet and sign up for our newsletter if you've already signed up and you've been a member for a long time you already entered.

[01:06:53] But if you have not ever signed up sign up for our newsletter, it's down in the bottom right hand corner of the bottom of the [01:07:00] website. We don't put it out there. There is a pop-up right now that says enter to win a set of Quick Change dumbbells. You can enter their May 31st will be announcing the winner of that.

[01:07:11] They're worth $619. They replace a thousand and fifty pounds of free weight very very cool stuff. Anything we need to talk about before we Britta that's it. The clearly filtered picture compared to Brita. If you watch this video, it's on YouTube. You won't you won't drink your Brita water anymore.

[01:07:31] You have to buy a clearly filtered water pitcher. I'm telling you. It's great. Thank you. Jason Lulu for helping out. Is there anything we missed Sean that you want to cover about his domestic response and environment diet. I think we covered a lot. Static, I think we did a great job. I mean, like I said when you're when dealing with these many responses simple changes can go a long way and the problem is if we get stuck in his metabolic pathways trying to look at cofactors when in doubt, [01:08:00] it's just we have to choke off the sources from where they're residing from and through the underlying pathology and taking consideration the actual Gene expressions.

[01:08:11] That are involved because the genetics are great because they do give us like a nice map to where the probabilities lie. And then we have to see if there's other you know, through history and labs and other data we have to see if those genes are expressed or not. Excellent. Excellent, but there's been a great interview.

[01:08:27] I'm glad we finally had you on you and I have been friends on Facebook for very long time. I've watched your writing your brilliant guy and. Actually, your Brilliance is so in a lot of people's faces that I think a lot of people come out very hard against you initially, but then they realize no he has the knowledge to back up what he's saying, which is really good.

[01:08:46] And I know you're good friends with another friend of mine, and that's Peter Rouse and so great work today. We'll have you back on and tomorrow we have the ReNew Life RX Show with Adam [01:09:00] Lamb and then Friday, we have the pep talk. We're going to be talking this Friday. At 3 p.m. Eastern with dr.

[01:09:08] Carl page about the nootropic peptides and one of them is actually isolated from porcine brain tissue, and I'm going to be trying it's called cerebral Eisen and I've heard that within minutes of an injecting it you feel it. It's like your brain wakes up. So we'll be talking about those peptides on Friday.

[01:09:33] So don't miss those. Thanks for being here today Shawn. Thanks a lot, brother and will talk to everybody [01:10:00] sooner.

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