Dr. Carl Paige, MD
The brain and performance enhancement is a popular area of discovery. Nootropics have been shown to promote better cognitive function. We explore a new area of Nootropics through peptides. These peptides can actually alter the landscape of the brain and help repair the damage experienced with aging and illness. The improved cognitive function is an aside to the changes in the brain function.
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Show Notes:
[3:45] You must have a good nutritional and health base in order for nootropic peptides to work off of.
- Once this is ensured, you will probably be able to notice something.
- Nootropic peptides are more than just upregulators.
- Dihexa affects angiotensin.
- It upregulates brain derived nootropic factor and augments neuroblastic regulation.
- It can also help with damage from head trauma.
- It is applied transdermally.
[9:16] Why transdermal for dihexa?
- Helps to prevent constant stimulation and down regulation of receptors.
[10:39] What about intra-cranial hypertension?
- Most nootropic peptides will help with the trauma caused by hypertension.
- Concerns with BDNF
[12:15] Any differentiation of BDNF with peptides?
- peptides work at the surface level and regulate themselves.
[13:25] RG-3
- Gensenoside derivative.
- Helps with brain trauma.
- Supports neuronal health and mitochondrial function.
- Works best with NAD+/ NADH
- Delivered nasally. (nose spray).
- Can be used ongoing without de-sensitization.
[16:50] Selank
- Fights inflammation.
- IncreasesBDNF and neuronal plasticity.
- Interacts with the melanocourtan system.
- Acts on the GABA receptor.
- Can be used to help recover from trauma during high stress situations.
[18:46] peptides seem to alter architectural system of the brain rather than just giving sensations.
- Selank dosing- 5 out of 7 days per week.
- Nasally or injected.
[25:55] Semax
- Nasally or injected.
- Melanocourtan 3 and 4 agonist.
- There is data for its use in stroke, TIA, and cognitive function.
- Helps to balance dopamine/serotonin and norepinephrine.
- Does not over stimulate like an SSRI.
- It does, however, need to be cycled off.
[27:50] The synergistic effect of Semax and Selank.
- Very few complaints about sleep issues.
- Dosing- 2 days/week of Semax, 2days/ week of Selank, then take a few days off.
[30:15] Efficacy reports.
- Not stimulating like caffeine.
[32:35] Known contraindications
- Neurological issues such as seizures.
- Usually a heavy metal detox as well as methylation optimization is done before prescribing nootropic peptides.
[34:34] Nootropic peptides burn through cofactors faster.
- Make sure to get a higher intake of choline when using nootropic peptides.
[35:30] Cerebrolysin cycles for APOE-4 gene.
- Heightens senses.
- More vivid dreams.
- Must be used sub-q, IV, or Intamuscular.
- 1ml daily for 30-40 days with weekends off.
- Go through this cycle 2-3 times per year.
[39:58] Epitalon
- Pineal peptide.
- Helps to reset circadian rhythms.
- Has more of an indirect nootropic effect.
[41:30] Can Semax/ Selank reverse stress related damage to the immune system?
[43:25] How to get prescriptions for these peptides.
[50:20] Peptide use for animals. (BPC-157)
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[00:00:00] Prepare to experience the strongest radio allowable by law. She will be revealed miss this about Jim where excuses never apply it superhuman radio with your host Carl annoy.
[00:00:31] Hey, welcome back to another episode of Superman radio. This is the every other week Friday show. This is a special show called the pep talk. Well, we talked about peptides and today is really an exciting day because this is an area that most people don't think about when they think about peptides if you're watching right now on Facebook and you're watching as part of a watch party.
[00:00:54] You may want to come over to the Superhuman radio network page facebook.com forward slash. For human [00:01:00] radio network and watch there because then you can post your comments and we will see them and we will try to answer questions as time permits. So the movie Limitless was all the rage because everybody wants to have a super functional brain everybody recognizes the potential value to dominate whatever it is that you want to dominate if your brain functions optimally or even super optimal.
[00:01:29] Which let's face it that's really what we want. And when we think about nootropics, we don't think about peptides but that's all changing. Thanks to people like my guest today. Dr. Carl Paige who is a part of the Mastermind group over at the international peptide Society. How you doing? Dr. Paige?
[00:01:48] I'm doing well. Thanks. I have to believe being inquisitive. And loving science the way [00:02:00] you do this area of peptide science has to be intriguing to you as well because let's face it the better your brain works the better you can serve your patients, right? Absolutely. You know, I want my body to work well, but the brain is the most important part.
[00:02:16] It's how you interact with the world and process information and it's the most important. Yes, absolutely. So. We know there's lots of over-the-counter products out there that are being sold. Some of them are blend some of them individual ingredients. There's mainstream commercials for something isolated from jellyfish.
[00:02:38] That was a discovery blah blah blah that's going to make your brain work better. How do the injectable? peptides that seemed to have nootropic benefits that were going to list today compared to things that are over the counter. Have you ever used any over-the-counter nootropics? Did you use any of the racer Tam's back in the day?
[00:02:58] I know I did in early 2000s [00:03:00] that you can you compare the the injectable peptides to the over-the-counter kind of stuff not on a personal level, you know at that time. I was not really using a lot of those my brain was still working very well on its own at that time in. I feel like I needed anything to give it a boost.
[00:03:17] I needed something to slow it down, you know the you know differences the you know, ultimately you've got to start with some of the base stuff we talked about last week. If you don't have adequate growth hormone levels nutrition, whatever you had in from a peptide standpoint. No tropical is not going to have a good base to work on.
[00:03:38] So even the GH R HG H RP B P1 abc15 sevens or. Going to make your brain function better from a cellular standpoint energy production standpoint. You've got to have the nutrients on board to get maximum benefit out of these. So the thought of just so quick when you're not taking care of the rest of the system.
[00:03:57] You're still not going to get maximum benefit or [00:04:00] maximum Effectiveness out of that and that's a really that's a that's a very important distinction and I want to I don't want to dwell on it, but I want to hit on it again. If you're really living a crappy lifestyle, if 80% of what you do is counter to health and functionality then taking some nootropic peptide or even over the counter nootropic probably isn't going to do much because if you've got muddy water already taking a spoonful of the mud out and adding clear water in it just gets.
[00:04:32] Turn back into muddy water. I mean really right. That's a great analogy. I it's just you've got to have the whole picture. If you're really looking for Optimal Health and performance. You need to fill in all the holes. They're not just thinking no Tropic out of the closets going to suddenly make you a super super brain now, assuming you are one of the people who does do the other things required for beneficial.
[00:04:57] Functionality you your sleep is protected. You're getting good [00:05:00] sleep. Your diet is healthy and healthy as a ubiquitous term. That means nothing anymore. But let's just say that your diet is working for you the lack of better term that could be keto it could be high protein. Whatever your diet is working for you.
[00:05:12] You're very active. You stay mobile. You stay active and now you add nootropic peptides into the mix. You think you feel them then? Yeah you well, you know I do when I use them the the I try to look at when patients come in and ask about that or they're, you know, oxidative stress load are they inflamed do they have an autoimmune process, you know going on because all of those things happen in the brain and just general life things can trigger that from micro traumas to history of concussions.
[00:05:47] They have chronic infections or inflammatory States or autoimmune disease and if those are present in that patient, which all of them maybe but not necessarily to disease level then Noah Tropics essentially work in [00:06:00] ways to qualify some of those processes in the brain and allow it to function better.
[00:06:03] It's more than just up regularly going to neurotransmitter or so to try to make the brain working over and that's a really important point to segue into the first one we want to talk about today, which is die hex. Now die hexa is interesting because it works on Angiotensin one of the Angiotensin 2 or fewer the Angiotensin an NGO tensions are implicated in metabolic disorder because they cause vascular constriction.
[00:06:31] So, how does die hexa work and and is this something that if someone is suffering from. Known vascular constrictive irregular Venus response is die. Hexo really a better alternative for them. It could be you know, it's one of its main Hallmarks is up regulation of bdnf brain-derived neurotropic factors.
[00:06:56] So, you know, if there has been vascular injury, it's going to [00:07:00] help with that, but it's also going to augments a neural recovery. No augment, the neuroplastic is opposed to neuro plastic response to know new nerve growth new nerve differentiation and development with the bdnf up regulation and that often is going to allow the brain to recover from some of the previous injuries.
[00:07:21] That might have had just from Life. What about acute ischemic event? What about a stroke or a TI a we would die. Hexa be something that would be beneficial. Maybe not going to turn it around but be. Sure, anything that's going to upregulate bdnf is going to augment recovery from from major trauma, like a head injury or blast injury or like I said just previously the micro traumas that you get from oxidative stress and inflammation, you know b d and f is going to augment that recovery process and it's about seven times, you know, more potent than bdnf and its function, you know how it triggers that so through the [00:08:00] have had a slight growth factor pathway.
[00:08:02] And potentially it's potentiates its receptor to function very effectively at the pmf function. What is what is how is die hexa taken? That's obviously a peptide has to be reconstituted. What kind of dosing for what length of time what is the protocol currently don't have a good supply of it at the moment.
[00:08:22] No, the dosing is being worked out the most effective ways to get consistent dosing looks like it's going to be transdermal. Introduced as a cream somewhere around a half an ounce and a male 20 milligrams per ml creams, you know, that's that's a consistent way to get the dose and also have a product that doesn't require, you know, reconstitution and Sub-Q injections.
[00:08:47] It's nice especially with some of the you know, kids or younger people to have that option. Okay. Wait a minute. So there is this a tripeptide or I mean, this is obviously. A smaller peptide. [00:09:00] Oh, no. It's an oligopeptide. So that's five right price small. It's gonna be small. Yeah, so it's around 500 Dalton or less so it's yeah.
[00:09:09] Okay perfect. Yeah, so it's acceptable to try to get through the skin why why that way is prolonged or delivery more advantageous with this than just a Depo disappears and it's gone. You mean like Depo delivery? Is that what? Yeah, I mean what I call every injection a Depo. Let's face it if I take a growth hormone and I put it, you know to unit I use on my skin.
[00:09:37] That's a Depo of fluid that eventually gets leached by the local vasculature and dissipates. But I mean, I guess what I'm saying is why not inject dye. Hexa why is the the continuous or prolonged delivery more advantageous for this particular peptide? You know. I think it's furnaces and some more of a matter of product and keeping it in a [00:10:00] viable format.
[00:10:01] I don't think you necessarily need Depo with the dioxide. You know, when you like many things in neurologic rolled a few overstimulate, they'll desensitized to it fairly quickly and you don't want this constant stimulation. Your body will not lose its Effectiveness or potency with continuous stimulation.
[00:10:22] Many of them need intermittent intermittent dosing like as we get into the some of the other ones like Selangor see Max, you don't want to everyday use that for 30 40 days in a row that's impact will diminish over time. Okay, Patrick Rodgers since I talked about obviously Angiotensin, he asked what about intracranial hypertension?
[00:10:44] Is there any you know, what sort of what I'm looking for contrary nomination? I'm not aware of any specific research on intracranial hypertension, you know intracranial I didn't spell it quite right, but I know what they're talking about intracranial [00:11:00] hypertension is usually going to be post-traumatic this where you're going to see it.
[00:11:03] Usually there's a many of the no Tropic peptides, you know, cerebra licensee Max D X. I have a lot of information on not see that I actually see max length server license. I have a lot of information on your recovery post traumatic brain. That's where most of the information was initially found in drive.
[00:11:23] So it can help recovery from that damage caused the intracranial hypertension and and the one last question. So anytime somebody tells me something up regulates bdnf. I am of the thought process that willy-nilly bdnf is actually not desirable and also there's bad bdnf, you know if you use. If you use opioids or nicotine, the bdnf is specifically to strengthen the need for that agent the bdnf happens in the [00:12:00] area of the brain that actually causes addiction and that's a Hallmark of addiction that it's not just dependence but the brain actually gets wired to want more and more and more.
[00:12:10] So when we talk about die, hexa. Up regulating bdnf is there is there any blueprint in the brain already that says well, we need that bdnf over here and over here. That's why it's good as opposed to let yourself regular bdnf in the whole brain indiscriminately peptides in general, you know work at the cell surface level and then are going to be trigger plea of trophic Downstream effects.
[00:12:34] So, you know, they're not like a hormone like just bdnf goes in and it's triggers an. That's the beauty of peptide since they work at that cell surface level and play a troll quickly sort of regulate or transduce natural effects in the cell that they really self-regulate their stuffs in that far away and unlike a agonists like morphine that's going to go in and hit a specific receptor [00:13:00] and turn it on, you know peptides don't work in that fashion.
[00:13:03] Okay, maybe maybe. The term potentiation potentiates bdnf where it's needed as opposed to just like switching it on. Correct crap. No, right. That's that's correct. It's a regulator when I was at this. Okay. So let's talk to about the next one RG3. What is RG3? How does it work in the end the purpose of nootropic?
[00:13:34] Sure, RG3 is really a Jensen aside derivative and has a let's going to work for neural recovery and it's not usually combined with activated cobalamin or B12 allow the best impact with it a lot of work in brain trauma brain recovery brain injury. [00:14:00] It is the way I would work at that is is more of a support neuronal health and Recovery helps with the nad+ nadh ratio really works in peripheral and central nervous system augments mitochondrial function.
[00:14:16] You know, those are the basics of how it works works better when it's mixed with the nicotinamide Rob Assad with the RG3. That's the common way to use. And this is injectable, right? I mean June set aside comes from ginseng right? Isn't that where I first heard Jensen Jensen? Oh sod. Yeah Jim's ginseng aside.
[00:14:33] His arg3 is the derivative one of the ginseng has this right? It's not old ginseng right was the one that's been shown to be active in the neural recovery. Usually as a no spray is most often how its administered an interesting should direct Pathway to the brain then yeah. Yeah. Very very cool. It works is great like in like bio toxic illness or you know [00:15:00] about toxin mold related illness where you've had brain inflammatory autoimmune dysregulation can quell a lot of those symptoms early on and use it to try to recover symptoms while you're trying to get rid of the cause or the exposure can in some patients, you know, ginseng can by itself is not been shown to be a.
[00:15:22] Consistently great note row, but when you get to specific derivatives of it and when you're using them with things to especially balance nad+ nadh ratio, you can get a pretty significant response and people that respond RG3. Have you used RG3? Have you tried it? Personally? I have not. You know, I've had many patients use it I have not used it myself.
[00:15:45] I've tested myself for a lot of these things. But if I don't have them out as usually not describing something up my nose. Recreationally if it's a new product that I might be using in a kid or something. I'll usually try some samples of that just so I get a sense of side effects. [00:16:00] Okay now RG3 dosing and duration.
[00:16:05] It really can be used on going and it's not one of those that you can get a desensitization that's desensitization to easily. So really to affect throw that in recovery long term use if you see a positive responses is a great is. Okay, and this is an injectable peptide correct? Will RG3 is traditionally delivered as a nasal spray that the you know, that's I'm not injectable, but it's a peptide but it's delivered nasally.
[00:16:33] Okay. Okay. Did you know nicotinamide are you know is not a peptide? Yeah, that's all rolls. You could take that orally. Yeah, right, right. Right, right. Okay, let's go on to the next one, which is a very popular one. We hear a lot about from people and that is selling what is selling. How does it work?
[00:16:53] So Inc is a peptide, you know, it works as an analog of something called [00:17:00] Towson admits its defects in the bites inflammation T helper cells again elevates bdnf specifically in the hippocampal region. Kind of works on that Gad or you know Gad access of the body, which is a Gaba essentially enhances neuronal plasticity or recovery.
[00:17:25] It kind of delays in kefflin break down to and also has some impact on the land of court and receptors. I love that. Yeah, Lana team, you know, if you've worked with that and improves monoamine monoamine oxidase activity. It really works predominantly on the Gaba receptor in a way that kind of benzos do but does not have the addictive potential associated with Alex.
[00:17:51] Yeah, so cell like cells like is and C-Max were both used by the Russians early on their athletes their [00:18:00] space. Personnel and so on and then sell like was said to put people in the zone they felt very relaxed when faced with stressful situations. In fact isn't selling good to wreak. Is it selling or maybe C-Max one of them is actually used to help people recover from high stress occurrences.
[00:18:22] Is it is it selling? They both can be used in that way. If I was gonna go for high stress, I would probably go for more the salang right away anxiety, right excessive stress. You want to think more of C-Max kind of working more on that. It doesn't get some Gap effect, but it's more dopamine in searching nergic at that's what I was waiting for you to say so when we talk about nootropics because of the over-the-counter marketing of nootropics, Which depends highly on a dopaminergic response that makes you feel like oh something's happening these seem to be much more sophisticated in affecting the [00:19:00] brain architecture as opposed to Sensations as am I Gathering that from what we're talking about?
[00:19:08] I would probably go back to what we said previously about how peptides work in and play a trophic way, you know walk into the cell surface and then trigger Downstream it through the nucleosome multiple different cell lines can be impacted by these. So it's not like you took a dopamine crew precursor and then had extra dopamine around that's a simple way.
[00:19:30] We sort of used to think of neurotransmitters like this example depression. You're low on serotonin. Let's give you something. Floods the synapse with serotonin it kind of works for a little bit like with Zoloft Paxil Prozac you might feel better. But then you will become desensitized to that exhaust your serotonin pools and then you crash and then they've got to put you on serotonin plus norepinephrine, you know, or you know, just keep so it's do you want to think of it as not just overstimulating particular [00:20:00] receptor with some individual on or off switch but more again in the peptide world.
[00:20:05] It's about balance. About augmenting that cell to function in the way. It's supposed to and a very pretty Tropic way that impacts multiple different levels is a is a regulatory mechanism or of balancing the cell function back to where it should be. We're going to take a quick commercial break in a moment.
[00:20:23] So cell like dosing. How is it applied? What's the duration of use? Like a lot of Gaba things, you know, usually I'll start a patient on Swank if they come in and they meet a criteria from an anxiety or stress standpoint and with some cognitive impact associated with it. Maybe use it 5 out of 7 days for a week or so, but if they have a positive response to it a fairly quickly want to start.
[00:20:48] Maybe mixing insuline pussy Max two days a week one two days a week another one take a break on the weekends so that you don't get desensitized and lose effect from it. And I'm going to add there's a [00:21:00] question. I'm going to ask you when we talk about CMAC since they seem to be used together quite often.
[00:21:07] They seem to have a one plus one equals five type of a relationship. So I'm going to ask you to go ahead no. No, please. What is so I can see Max can be nasal or can be injectable either. So they're nice because you can use them across several different age groups or you know, it's nice to have that flexibility with these two peptides.
[00:21:28] Yeah, patient compliance. A lot of people don't want to inject for whatever reason I do not I just I just I know I just call them scaredy-cats. That's all I got. No, I mean, you know, I remember one of the first time I ever met gave myself an injection and I was freaked out. But once you realize that you can do it and you don't die moments later your final all the patients with these little syringes you could literally stick yourself a hundred times and you still not going to kill you.
[00:21:55] Yeah, I know exactly so what I'm going to save a couple questions [00:22:00] for after we talked about C-Max about salang so I may work. So like back into the discussion. We're gonna take a quick commercial break. We'll be right back with more of the sorry. I killed my oh my. More of the pep talk you're watching superhuman radio.
[00:22:12] Stay tuned post your questions post your questions post. Your questions will be right back. Welcome back. People have been messaging me saying hey, your microphone is up and we heard you coughing. Thank you. Thank you. I so getting back to the question at hand. We're going to now talk about C-Max, which is very very popular.
[00:22:35] Once again, we owe a lot of the research to the Russians, don't lie. Yes, because what is C Max? How does it work? See Max again. Most commonly used is either nasal spray or injectable. It activates dopa need open nergic search energix stem cell production also is a potential melanic Orton three and four [00:23:00] antagonist.
[00:23:01] And it's used a lot in chronic stress and really is an anxiety anxiety lytic antidepressant as a lot of data as well for stroke TI a memory cognitive mental fatigue. It's a potent immune booster and the CNAs and works help quell that inflammatory response you get centrally with whatever the trigger might have been trauma a stroke.
[00:23:28] And in fact C-Max is associated with balancing dopamine norepinephrine and serotonin levels, right? Yes. Yes, you get dopamine certain are jerk and. Balance is essential is a good way to put it, you know with the peptides again, you know, don't just go in and turn something on or off. They work to create a normal balance with that and that's it's sort of if you put it in the pharmaceutical world would be kind of like using something that's a dopamine stimulant [00:24:00] in the circuit is asara, but it's much better than that because it's not going to overstimulate a receptors going to create a nice balance so that it functions normally and helps it return back to normal.
[00:24:13] Tolerated well, it does need to be sort of cycled on and off usually with salang so you don't get tolerance to it, but very effective. You know, I've used that one as well as the select myself and it's it works quite well. So let's talk about seem accents to like for a second as a as co-conspirators for a second.
[00:24:35] Both of them are available in nasal spray. But what are the what are the doses in nasal spray? Like well how much you usually taking of each and the recommended daily dose? It's going to be one, you know two Puffs daily. You can use were if we need to but again of your more is not always better in but you know one puff in the morning one puff in the mid-afternoon, [00:25:00] sometimes when you hit the dopamine side of things you might get that, you know some agitation, but mostly it's called.
[00:25:07] Very few people complain of sleep issues with these so they can be taken morning or mid-afternoon. If your third shift worker you could use them during those times as well to augment ordinance without stress. So you get the awake alert, but without the anxiety part is it wise to take it before bed.
[00:25:26] If it seems to have a relaxing effect. Both of them see Lincoln and semak. You know, I would probably use more solanki in that world as it works more on the on the Gaba side of things. You can use them in the a if you want to is probably better to one one day one the other day and then take a take a break on the weekends to let the receptors up regulate intersect.
[00:25:49] By the way. I found an open mic for those of you who are saying that you could hear me coughing during the break. I actually found an open mic button. So I just pressed it. So that should be gone and I have no idea why. [00:26:00] The commercials aren't playing on the Facebook live, but consider this a commercial free show for you.
[00:26:07] It sounds like adaptogenic mechanism. So do you have a recommendation for cycling it you said how long do you take it and then take off again? I would you know, what I'll tell patients is maybe two days a week one two days a week of the other one and then skip a couple of days. And then you start back again in the following week you can do if I'm going to stay on at five days.
[00:26:31] I would do the one week you would do Monday Wednesday Friday silang. Tuesday-thursday C-Max the next week flip it, you know, Monday Wednesday Friday C-Max doozy 30 Susie 30 slang, but Tina skip the Saturdays Sundays when you put a patient on both of these on semak sense alike. What do you hear back from them?
[00:26:55] What do they say about how they feel what is change [00:27:00] anything? The majority of patients that I will do that with our people that have neuroinflammatory, you know illnesses that are maybe head injury issue cognitive decline just with aging we do use it sometimes in kids that have neuro inflammation associated with ADD autism spectrum disorders as well.
[00:27:21] The feedback you get with the adults is especially with cognitive decline of usually given them cerebral Ison as a cycle and then we'll follow that up with a you know, slang C-Max rotation after that the sort of maintain the effect for a couple of months or so and then maybe cycle them again with cerebral Ison the subjective effects that the patients will say is a improved sleep improve dreaming.
[00:27:48] I've heard enhanced smell ability to improve the ability to perceive smells have one patient who's an engineer is very focused. [00:28:00] He performs these Sudoku puzzles and says that after the cyclist of cerebral Eisen and NC Max and Salon Keys faster and execute more puzzles quicker. He notices that spits fairly subjective not just his objective opinion on it and and these and these and these have no stimulating effect will not talk about anything that uses a catecholamine type Cascade generation when Auto a caffeine, we're not talking about even acetylcholine promoter.
[00:28:31] This is strictly. This is strictly on a neuronal basis these at these effects are happening. Correct? It's not as not stimulating at all. They are not things that make you feel like you had for cappuccinos and then Ritalin, you know, it's not that type of effect that doesn't work for me anymore either by the way, I've gotten to a point in my life where the more caffeine I use the sleepier.
[00:28:55] I become does that mean I have ADHD. I don't know. I mean these are [00:29:00] these are the questions that I or my just burnt out on it. I don't. I would first of all first of all assume you might be burned out in that and maybe take a break from it for a little bit and see if you can regain some sensitivity and that takes a while.
[00:29:14] Yeah, and I think I'm actually giving caffeine up again for a while. So Darcy clock says are there any benefits or contraindications when taking these peptides with things like inositol l-dopa or lithium orotate? No, no contraindications, the main things if you're has unstable neurologic condition, you know, which might be seizures that are not well controlled that type of thing.
[00:29:40] I usually wait until we've got some assurance that those type of conditions are stable before we start working with modulating neurotransmitters or up regulating brain. Brain synapses development that type of thing but from the general healthy person, you know low dose lithium orotate. It's just going to work as a [00:30:00] bdnf up regular itself.
[00:30:01] So this is going to augment the effect the inositol and I think the other one was tyrosine. Is that what he said I'd have to go back and look at it whole lot of things because I am actually trying to. Q these questions, he said l-dopa, I guess he's talking about like mucuna farina's because I unless he's taking levodopa and Carbidopa It's gotta be an herb.
[00:30:22] Yeah. Well, I will a lot of times if we're doing bring recovery on these Patients First, you know, detox them make sure they're not full of metals, you know, do they have a chronic co-infections that type of thing correct methylation so that they can process neurotransmitters correctly through methylfolate pathway.
[00:30:42] Produce and clear neurotransmitters effectively and then look at membrane support with Fausto choline ethanolamine phosphatidyl serine because we're really trying to give bring recovery with these so absolutely those are certainly part of what should be involved in an overall World program you looking at nor [00:31:00] recovery.
[00:31:01] Sean Roberts, hang around I'm going to ask you a question at the end of the show because it doesn't fit it to the nootropic thing, but it is peptide related and. There's good answers for you. So stick around Sean Darcy then come back and says it doesn't does this cause a burn through cofactor like choline.
[00:31:19] I don't know what it means to burn through cofactor. Well, I guess he's if you're making a triggering your production of neural cells or you know, neurotropic effect, then neurotropic not new atrophic, but you would utilize more of the neural membrane. These chemicals, so you should definitely be supported well knows before you would so you'd have to supplement you have to make sure you're getting enough choline in your diet and things like that.
[00:31:46] You get maximum effect absolutely would be trying to build a house without mortar bricks make perfect sense. So now let's go to a really interesting one that we're going to take a break and we can come back and answer an interesting question. Also, we have to make a [00:32:00] correction from last show about eating before.
[00:32:02] Using certain Pepe. So the last one on the list is the one that's most intriguing to me because. It was said to me that when you use cerebro licen, you actually feel it. You feel your brain, like everything gets brighter you feel sharper. You feel it. It's noticeable. Now II have a feeling you've never tried it what have.
[00:32:27] That's not correct. Okay. I'm trying to read I have an APO III for genotype. So with the apoe genotype, especially the 3/4, but definitely with the four fours lot of information of the use in that for no recovery to prevent in regress plaque formation. You know from a cognitive decline standpoint.
[00:32:48] So I've actually used shrivel license Cycles several times and have used it with a lot of patients in that Arena. So you're right. There is a heightened sensation [00:33:00] smells tastes visual Acuity at least a sense of that more Vivid intense dreams, you know, these are just the feedback I get from patients and I've experienced some of that myself.
[00:33:13] It doesn't make you have bad dreams. But if you're in a bad mood, you might have a bad dream, but it would be a more 4K dream is what I would say more. Yeah, it's more detail. Yeah. Yeah, we're detail and in the you know, yes, you do feel that especially with the first of a cycle when you first start it is noticeable and it is this a peptide of correct me if I'm wrong.
[00:33:36] Is it this a peptide that is isolated from porcine brain tissue. Correct. It's a it's a plea a Tropic peptide. Meaning that the mix is slightly different depending on which you know, which which one it's manufactured sensually, so there will be some variability from batch to batch but the group of chemicals are the same chemicals, you know, and they'd are small less than 10,000 [00:34:00] Dalton's cross.
[00:34:00] The blood-brain barrier does have to be. So Q I am or IV and be administered and all those formats. It's too large for transdermal. It's not you but nasal, right? Right and you would use the cycle of it. Essentially 40 CC's administered is a over maybe four weeks or maybe over a couple of weeks depending on the goals.
[00:34:23] If you know, well how many days it? Could you did it? Is it administered in micrograms or I use if I'm if I have some and I want to inject. How is the dosing and and do you also have to cycle on and off of this as well? Like the sea lion can the C-Max it's a standardized concentrations, but I usually just look at it as ml.
[00:34:41] So used to say 1 ml daily for 40 days or 2 ml day for 20 days, maybe five out of seven is you know Skip the weekends again not as clear you have to really take the days off on the estimate is just to give patients a break you can I'll use it in. Maybe people with [00:35:00] dementia. It is a 10 mL IM dose weekly for I saw that research.
[00:35:03] It's very impressive very bright and plus you don't have to chase them around and get them to take their medicines and probably you know, it does quite well like that. They can't self-administer that usually but they'll come in the office and get that or we have an in-home care taker to labret like that and and and does the heightened awareness and heightened sensation.
[00:35:25] Dissipate the more you use it or is it something that you experience every time you use it on going? It's usually we think of it as a cycle of you know, two or three times a year. You would go through maybe a one month cycle of that in the interim might you see Max and slank alternating. If you have an acute injury and you're experiencing recovery, then I might continue that one month or two months, you know, if you have a tremendous response, then you wouldn't pull it away.
[00:35:52] Um, you know, I've used it a couple of months in a row, you know with breaking on the weekends and of her patients as well from a recovery [00:36:00] standpoint did not see really in a diminution of recovery effect. Then it comes down to the really just costs too sometimes, you know, none of these especially sure the last is not the least expensive one of those to try right now.
[00:36:13] We're going to talk about that in the last segment about how people can get these from their doctors and all that sort of stuff. So while this one isn't thought of as a nootropic people who use it for its purported age-reversing effects seem to say it also has nootropic effects. And and that is repet Allen.
[00:36:40] Does Epi Talent Fallen to also kind of cross over to nootropic World at. It can I usually think of that but Alan Moore is a punny. It's a pineal peptide rights, really Recycling and resetting circadian [00:37:00] rhythm. So obviously if you're not going to sleep or get deep sleep, you know, Delta restful sleep recovery sleep if we get you to have a normal circadian rhythm and get restful sleep.
[00:37:10] That's no traffic in and of itself, right? So it's probably some old. So to call it a true no true. But it certainly can have an indirect effect like that and I want to do a separate show while with thinking about it and talking about it on a Pete a lawn and penal on that research that came out of the Russian group there and I want to get your opinion on it to like do you do buy it because it's pretty impressive stuff.
[00:37:35] So we'll put that on for a future shows. So okay. I'm listening to the show today. I'm out in the audience. I go man. This stuff really sounds interesting because this isn't your typical nootropic. Hey, it makes me feel like I'm moving a hundred miles an hour like you said before I've just you know, taking some Adderall in a couple espressos, but instead it [00:38:00] actually repairs the brain and that's really what it does.
[00:38:03] In fact some of the work on both C-Max and silang correct me if I'm wrong showed that it actually reverse. Stress related damage to the immune system. Now we're not even talking about the brain right? We'll talk about the immune system now and so these are really these are good. I'm sorry. Well, I think a lot of that's going to be from a CNS standpoint with like microglial upregulation.
[00:38:32] So the microglia are your you know, sort of response team from an inflammatory immune standpoint in the brain. And unfortunately when they get triggered to be on whether that's a traumatic event or whether it's an inflammatory events and autoimmune event and infection. Sometimes they get stuck in the on position and they can help return those to the quest and phase always get a mixed up as the M1 or the into face, but they were returned to class and phase and then so [00:39:00] hopefully then with repeated triggers.
[00:39:02] If they're already on then it's just going to pour more fuel on the fire. If you get them to become quite essent, then you can start to get recovery. But if there's ongoing inflammation, it's very hard to recover. No subscriber licen directly can protect nuanced predominately from oxidative stress lactic acidosis a glutamate toxicity and you can get metabolic recovery and so normally.
[00:39:26] It's a normal status down-regulation of that chronic inflammatory response, which is Noah trouble because it enhances cognitive memory function in motive. I guess you're right because all of a sudden more areas of the brain become. And it's like you just upgrade upgraded your RAM and your hard drive and everything.
[00:39:44] So you are gonna absolutely affects. Yeah, I get it. I didn't think of it that way first time that cheaper him out and put in some of the fastest. Yeah, exactly exactly. But it does not feel like a stimulant. It's really not that type of experience at all, but it's very I like it. I you know, I use it a [00:40:00] couple of cycles of a year and if I get sick or have something I'll throw in a third cycle person.
[00:40:05] Um, so someone's in the audience listening to the show. They go Chi, you know, I want to get on some of these things. They have to reach out to their their family physician first, obviously right their family physician says, I don't even know what you're talking about. So then their family physician should go to the international peptide society's website and sign up for membership and then they will have access to all the science on using these peptides in administering them and then.
[00:40:34] Family physician also needs to contact tailor-made health or compounding pharmacy and Nicholasville, Kentucky because that's the only place that is FDA approved to produce the peptides that were talking about today and they can fill the prescription and so it doesn't matter where you live if you don't have access to a good physician, which is quite often.
[00:40:55] The case, but you may have access to a physician. [00:41:00] That recognizes your into your interest your intent and your intelligence and you can say I really want these things and they kind of fall under the heading of Can Do no harm anyway doc. So could you go to the international peptide society's website and educate yourself about this stuff because I would like to be able to write a prescription have it filled at tailor-made compounding because I want to use this do you think that that is the.
[00:41:25] Really the path of least resistance or should they start seeking out doctors who are already doing this? You know, the peptide is technically fall in the grass status or generally recognized as safe which means the FDA has approved them from a safety standpoint. They have not been. Picked up by big Pharma and ran through billion dollars of research to to be FDA approved for targeted diagnosis.
[00:41:49] And it's a common question. I get in the office. I tell the patients that you really don't want it to go through that process because when it does it's going to cost 40 times more than it does now write [00:42:00] your has far as access to care. There is at this point a limited number of professional providers who are probably familiar.
[00:42:08] In educated in this process about how to obtain these type of peptide. So I would start with your local primary care physician. Absolutely. Hopefully they're going to listen and be curious and want to seek out information on their own. If you get hit a brick wall there. There are ways to access care.
[00:42:26] I mean we see patients here in the office at least once and then we'll have remote follow-ups with them. There's some gray areas from a lost and point about. Transfer of medical information and prescribing but you know that's going to clear itself out here in the next few months to years to where I think patients will find access to these not that difficult.
[00:42:49] Yeah, and I don't I don't I wonder if IPS actually has a find the physician or member in your area on their website and now they have a [00:43:00] list of. Choose up not sure if it's geared is a search function yet. I'm not used to that. So I'm not hit that button yet on the site. That would be how full if they do.
[00:43:09] I may try to visit their website during the commercial break. We're going to take a break and when we come back, we have a question from a listener about animals, and it will be an easy one to answer actually and then we'll also let you. Talk about a statement that you made that when you listen to yourself on the video, you realize oh I misstated something will clear that up on we come back stay tuned.
[00:43:30] Welcome back. So this is a really easy question to answer. Actually it comes from Sean Roberts who I believe is listening in the UK.
[00:43:45] Sorry to cover your face up with this one Doc. It's a long one. I'm gonna get right to it peptides and. A peptide such as bpc 157 and TB 500 just as effective in dogs were healing. Are there any well-suited from other [00:44:00] mammals in general? So you want to go ahead and take a stab at that? Well, first of all, I'm not a veterinarian so I can't be an expert in that area.
[00:44:09] You know Todd's in general are concerned across similar species. From a logical standpoint. I would say that they probably would work as well across the similar mammalian species, but I would recommend that you consult. I have not researched that data personally and depths like that make a specific recommendation.
[00:44:31] I am not a veterinarian either. But I'm not a doctor so they can't take anything away from me. Yes, they work listen. TB 500 if I was in beta for was being used on Thoroughbred racehorses before it's being used on humans because what's that? Yes, I didn't really want to bring in the horse world.
[00:44:53] But yeah, no no and and the dog racing industry has been using TB 500 forever as well. [00:45:00] So they use the what were you what were you just in the marina in and really have the same player Tropic effect and an excellent safety data as well. So I mean these guys are used in large doses on these animals because these animals make a lot of money by being able to race and if they can trace they are costly to maintain and so yes, I'm not, you know, I'm not aware of the.
[00:45:25] Drug status in the animal world either speed would want to be aware of that before you started using in any of these peptides to make sure they wouldn't be detectable, you know, some of the money involved in the racing world. Can they test them for a lot of things as well? That's not my area of expertise either.
[00:45:43] Yeah. No. No, I agree. And I don't think they I don't think they care about TB 500 to be honest with you. But anyway, I mean if you're just a pet owner and you have a dog or that's sick and you think that 2500. Yeah, you can I would administer small doses small doses that's all used [00:46:00] maybe half of what the human dose is supposed to be and start there and watch what happens.
[00:46:05] But yeah, they're already they've been using these things on animals before they were using them on people and so they are, you know, not really. These are just broken down into obviously and recycled essentially, you know, true peptide small sequences of amino acids, the you know, clear way different way than prescription medicines that might have to be sip enzyme cleared and pass through Phase 1 c 3 metabolism to be cleared from the body peptides don't really have that type of reaction.
[00:46:41] Yeah, exactly. And I think we've covered it. Also now the other thing that you did want to so last week when we talked about the growth hormone secreted dogs. You said that taking a secrete agog you should not you said should not eat any fat or protein [00:47:00] for I think an hour before or something like that, but then you said that wasn't correct afterward.
[00:47:04] What did you mean to say? Yeah, that was a statement of my part when I listen to the podcast later. I was it's really. Fat and carbohydrate that you want to avoid an hour and a half to two hours before before injecting and of course definitely also patients frequently questions kind of drink alcohol before the peptide injection and like you really just wasting it, you know, if you want to go out and have a few drinks with your friends then don't use your peptide that night because it's not going to do anything.
[00:47:33] You muzzle squirting out in the room. Yeah. There you go. That's good plug your website also, so people listening to the show who will living within. The Louisville driving distance area may choose to come to you to get there see Max and say link and cerebral Ison. Sure. Thanks a lot of medical transformation center.com Louisville Kentucky.
[00:47:55] It's where we're located phone number there is oh gosh. Don't ask me that. I mean [00:48:00] if I can play wait, wait wait, I had your Dawn website up and now it's gone. I just dialed it. Hold on a second. Hold on a second. I don't call myself often. Is it it for for nine? Wait for four three nine nine six two that sound familiar.
[00:48:15] That's correct. Five on two four, four three nine nine six two two. They want anything about yes International peptide. They do have a spot on their site for physician referral you leave your name and number and someone will contact you back from their about a local provider. If you have one as well and other societies are popping up out of nowhere now just for just a heads up because this is how it happens.
[00:48:41] IPS is the leader. They are the only ones that are endorsed by a for em, they're the only ones that actually trained a4m doctors to use and prescribed. peptides but of course, there's going to be other people that are going to come out of the woodwork but IPS [00:49:00] at peptides society-dot- org is the only one you should be paying attention to the others are going to try to capitalize on what they think is an opportunity.
[00:49:10] But IPS is the one that training hundreds of doctors all over the United States already. Correct. That's that's want to go out there and tell folks that listen. Thank you so much for being on the show today. Thank you. Thanks for having me and we'll see you in two weeks. Maybe we'll do in two weeks.
[00:49:25] Let's do the the penal on and that be talent show because the research behind that is quite exciting, but whether or not it holds up to the rigors of science will let you decide on the next show. How's that sound? Okay. Good deal. Thank you so much, dr. Page and we'll see your body Monday with more superhuman radio.
[00:49:44] Thank you for watching Hope watching today. See you [00:50:00] then.
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