Dr. Elizabeth Yurth, MD

The National Institute of Health estimates over 20 million people suffer from peripheral neuropathy. They also acknowledge that this number may be highly under-represented since there a other forms of neuropathy that don’t cause pain. Add to that only recently it was shown that Fibromyalgia has a neuropathy and small fiber nerve damage component so add to that another 12 million - almost all women. The most insidious type of nerve degradation that rarely gets reported due to lack of pain attacks the organs in the body. Remove the nerve impulses from the heart, liver, pancreas or brain and slowly your body begins to fail. Most neuropathies are treated with drugs like Cymbalta in an attempt to mitigate the pain. They often don’t work and carry horrible unwanted effects. The peptide Cibinetide (ARA 290)  looks to be the first thing that addresses the problem by fixing and repairing the nerves as opposed to masking the symptoms.

{mp3}https://dts.podtrac.com/redirect.mp3/superhumanradio.net/components/com_podcast/media/mp3s/SHR_Show_2455.mp3{title}SHR_Show_2455{end-mp3}

SHR # 2455 :: The Pep Talk: This Groundbreaking Peptide Can Treat Neuropathy, Neuralgia & Fibromyalgia

Show Notes:

[4:55] Peripheral neuropathy and fibromyalgia.

• A vast number of cases go undiagnosed or attributed to age.
• It is due to nerve degradation.
• Chronic pain spans an even larger % of the population.
• It is a neural inflammation problem.

[9:00] Inflammation will usually elevate appropriately, but it doesn’t tamper down correctly.

• Aro-290 can resolve that inflammation.
• The most harmful drugs are the ones that trick your brain into not feeling the pain i.e Gabapentin.
• Others just shut off inflammation (NSAID)
• This class of peptides actually resolves the inflammation and lets it do its job.

[13:06] Clinical trial results.

• Rodent and human trials.
• Rodent- after cibenotide was applied, nerve damage disappeared.
• Human- 16 patients, double blind study.
• Nerve regeneration in corneal tissue and even better results in their skin tissue.
• 6 minute walk test.
• Patients that couldn’t walk due to pain improved walk gait and had less pain.
• Gait speed is actually correlated with life expectancy.
• Improvement was noticed in as little as 3 days.

[30:00] Fibromyalgia

• This peptide would be a logical treatment option.
• Fibromyalgia should be treated as small fiber degradation.
• There are only minor side effects to ARO-290 as opposed to those of the conventional treatment drugs.

[34:26] Silent GERD.

• Innervation to esophageal sphincter is degrading.
• The core of the sick, aging phenotype is the degradation of the nervous system.

[37:28] Why is ARO-290 helping with metabolic disorder?

• Carl hypothesizes that the enhanced electrical flow enhances organ function.

[43:10] Price?

• $1100 per cycle.

[48:50] Improtance of removing the insult that caused the injury.

[54:05] J-147

• Curcuminoid like supplement.

[54:50] ARO-290 in combination with GH secretagogue.

• Can increase IGF-1, which will raise fibroblast growth factor to create new nerves.

[56:03] Iron drives demyelination.

Show Transcript SHR # 2455 :: The Pep Talk: This Groundbreaking Peptide Can Treat Neuropathy, Neuralgia & Fibromyalgia