SHR # 2497 :: COVID-19 and Chronological Aging: Senolytics and Other Anti-aging Drugs for the Treatment or Prevention of Coronavirus Infection?

: Carl Lanore; 06 April 2020; 29 August 2022

COVID-19 and Chronological Aging: Senolytics and Other Anti-aging Drugs for the Treatment or Prevention of Coronavirus Infection?

Dr. Michael Lisanti, MD - PhD

The oldest in our global population have suffered the greatest mortality from this pandemic outbreak. Experts warn that this of us over 60 years of age are at greatest risk of dying. Many of us in this audience already use senolytic agents to help push back biological aging. Are these strategies helpful in protecting against COVID-19 as well? Is there a difference in the death toll of those who are chronological 0ver 60 years old versus a 65 year old person who is biologically 40? And what of time restricted feeding? It imparts some of the same benefits as senolytics. We learn the answers to these and more on today’s show.

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Show Notes:

[4:12] Z-pack as an anti-fibrotic and anti-inflammatory. It also has anti-viral properties. There are other senolytics that can act in a similar fashion: Rapamycin, Doxycyclin. The work, partially, by reducing mTOR and protein synthesis.

[13:32] Blood sugar management and senescent cell synthesis. This concept could be tissue dependent. IL-6 seems to be the real culprit in the virus problem.

[17:23] Fibrotic tissue treatment from a Z-pack?

[21:32] Biological age and risk factor?

[33:43] Time restricted eating? It could be prophylactic.

[39:20] do these senolytics turn senescent cells into quiescent cells?

[52:05] the takeaway on senolytics? They could be a possible prophylactic for healthcare and essential workers.

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