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SHR # 2565 :: Science and Development of Muscle Hypertrophy + Study Shows 141 Genes Responsible for Rapid Muscle Loss

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Dr. Brad Schoenfeld, PhD

Few people have studied how to build muscle more efficiently than Dr. Schoenfeld. Carl respectfully refers to him as Doctor Hypertrophy. From his original mission of helping people Look Good Naked to the science and real-world applications of building muscle faster that have been adopted by the words best strength and physique athletes, he knows how to give you the physique you’ve dreamed of having. In his latest book “Science and Development of Muscle Hypertrophy“ he puts a finer point on the process than ever before. Come join the fun and be part of the live show on Facebook (https://shrnetwork.biz/FBLIVE) or YouTube (https://shrnetwork.biz/YTLIVE) and post your questions. PLUS A study out of McMasters University investigates the progression of muscle loss against muscle gains over 10 weeks in young men. The results are shocking but make sense when you use evolution as the backdrop. This is yet another study that shows Physicians should be able to prescribe resistance training with a competent personal trainer.

Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States   
https://pubmed.ncbi.nlm.nih.gov/32755574/

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SHR # 2565 :: Science and Development of Muscle Hypertrophy + Study Shows 141 Genes Responsible for Rapid Muscle Loss

Show Transcript SHR # 2565 :: Science and Development of Muscle Hypertrophy + Study Shows 141 Genes Responsible for Rapid Muscle Loss


Show Notes:

[4:21] The science and Development of Muscle Hypertrophy.

  • 2nd edition textbook.

[6:20] How to assess muscle building progress over time.

[9:00] The book lays out several variables that can be altered to build and maintain muscle mass.

[17:13] Lifting as you age.

  • Osteoarthritic issues are more common. This could suggest possible benefit to backing off from 1-5 rep maxes.

[20:10] What about advanced techniques?

  • It all depends on the context in which you incorporate them.
  • Heavy negative and loaded stretches have potential for higher muscle damage.

[24:10] What about aerobic exercise’s effect on muscle building?

  • It can be very beneficial if properly managed.

[30:37] Nutrition.

  • Most “hardgainers” are just not eating enough.

[31:30] ampK activators.

[36:00] myostatin.

  • It is a myokine that acts as a governor on muscle growth.
  • Its role in training remains questionable.

[40:30] NSAIDS.

  • Chronic use in young people blunts hypertrophy.
  • In individuals 60 and older, it starts to have a neutral to positive effect.

[48:40] Where to use BFR in your program.

  • Use in tandem with heavier movements.
  • Better for single joint movements.

[51:32] IGF-1 ec (mechano-growth factor).

[53:00] Any new thoughts about test levels and muscle?

  • You can still build muscle at hypo gonadal levels. The effects will be blunted though.

[1:04:33] Study finding 5x faster muscle loss vs. gain when you individuals were immobile.




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Super Human Radio is the world's longest running broadcast dedicated to health, fitness & anti-aging with an emphasis on exercise, nutrition, and hormone management. This one of the most progressive podcasts for preventative & regenerative techniques designed to increase longevity. More

2908 Brownsboro Rd Ste 103
Louisville, Kentucky 40206

(502)-690-2200

SHR Logo

Super Human Radio is the world's longest running broadcast dedicated to fitness, health, and anti-aging with emphasis on exercise, nutrition, and hormone management. The most progressive source of information for preventative & regenerative techniques... More

2908 Brownsboro Rd Ste 103
Louisville, Kentucky 40206
United States of America

+1 502-690-2200