Regenerating Dopamine Production

[00:05:57]   Lucas explains his fascination with Dopamine.

[00:06:19]   The prime neurotransmitter associated with success, dominance and motivation is dopamine.

[00:08:25]   A discussion on the newest dopamine agonist drug on the market, Apomorphine, ensues.

[00:10:23]   Is dopamine production cyclical, or is it on demand?

• In general, in the brain, dopamine levels are fairly consistent in terms of its cyclical production.
• Dopamine is synthesized from the beginning substrate, L-phenylalanine.
• It is then converted into L-tyrosine, then into L-dopa and then Dopamine.
• There are many other co-factors involved in the process, vitamin B6, zinc, magnesium et.

[00:11:45]   Which dopamine converter do people most commonly have a lack of?

• Globally, the nutrient most people are deficient in, is iron.
• Iron is essential to convert l-tyrosine into L-dopa.
• B6 also plays a crucial role.
• Iron however has to be managed as iron can cause severe oxidative stress.
• People on the anemic end of the spectrum do have a decrease in dopamine receptors.

[00:15:09]   How does the microbiome contribute to the production of Dopamine?

• 90% of serotonin production begins in the gut. The same also holds true for dopamine.

[00:18:26]   What hormones compliment or hurt the production of dopamine?

• There is an inverse correlation between dopamine production and prolactin secretion.
• There is also a correlation between total testosterone production and dopamine output.
• A strategy to improve dopamine production should include something that mildly suppresses prolactin.
• A discussion on safely suppressing prolactin levels, follows.

[00:24:05]   The most acute effects noticeable when dopamine levels rise, will be an increase in mental clarity, resilience, focus and motivation.

[00:24:27]   Does caffeine abuse cause dopamine to drop?

• Caffeine is a typical stimulant; they borrow from tomorrow.
• There is one particular nootropic for people who abused heavy stimulants chronically, Uridine monophosphate (UMP).

[00:27:32]   Maca root effectively increase dopamine production. It usually has a pretty fast onset.

[00:34:33]   Are there diets that predispose people to production of dopamine?

• Diets rich in monounsaturated fats.
• A lot of organ meats.
• Avoid high GI foods.
• Anything that worsens insulin resistance is also associated with poor production of dopamine.
• Glyphosates deplete and strip the body of key nutrients like manganese, and manganese deficiency is also associated with low dopamine.

[00:36:40]   Any sort of sleep deprivation will exacerbate any sort of neurodegenerative disease.

• Meditation is known to increase brown matter in the brain.
• There is a correlation between dopamine and self-awareness
• Dopamine can increase introspective behaviors.
• Carl follows this up with an ant story.

[00:39:48]   Psychedelics like Psilocybin function as an agonist at the 5-HT2A receptor. That leads to a downstream release of dopamine and glutamate. A discussion on both the abuse of recreational drugs and the effects thereof as well as therapeutical use, follow.

[00:44:36]   Lucas explains the term “learned helplessness” – fascinating!

[00:54:34]   Mitigate post sex prolactin rise by using a stack of 500 mg of L-phenylalanine, 25 mg of Bromantane and small amount of vit E sublingually.

[00:56:25]   Stack to optimize dopamine production.

• L-phenylalanine.
• B vitamins.
• Focus on the tyrosine hydroxylase enzyme.
• Coleus Forskolin.
• Lower basal levels of serotonin if necessary.

[01:04:31]   Are there ways to assess dopamine levels in humans?

• The Braverman test is the only way at the moment.

To learn more about Lucas
www.youtube.com/boostyourbiology