Jacqueline Seymour
Jacki is a Master’s student at USC, home of Dr. Valter Longo’s Longevity Institute, where she’s studying her passion for life: Gerontology(the science of aging) and Nutrition. 

Your Guide to Exercise Mimetics: NMN as an Exercise Mimetic

Two Heavy Hitters in the OTC Anti-Aging Arena

[00:04:47]   Scientists from Rutgers university published a study that relates to aging. The study showed that cellular senescence was triggered by glucose signaling, meaning when your blood sugar goes up, the body does a host of things to manage that. Those things are the first domino that fall to create a senescent cell.

[00:06:01]   The number one thing that makes you age in a bad way, is the sugar in your diet and your body's response to that.

[00:06:16]   Sugar activates different pathways in the body, which lead to very negative consequences:

• Poor insulin sensitivity
• Activation of mTOR (mammalian target of rapamycin)
  • m TOR is critical for repairing tissue, however having mTOR turned on all the time is not a good thing.
  • mTOR and AMPK (AMP-activated protein kinase) must be balanced.

[00:06:56]   In today's society most people over consume low quality, high sugar foods, which keeps mTOR turned on all the time. One of the most critical windows to avoid turning on mTOR appears to be about three hours before you go to sleep.

[00:07:25]   Dr. Dale Bredesen (author of The End of Alzheimer’s) proved that those who stop eating about three hours before bed actually can reverse the cognitive decline found in dementia.

[00:10:27]   Dementia is a symptom of:

• Poor glucose utilization in the brain, which is the “type three diabetes”,
• It also could be plaque buildup in areas of the brain that are responsible for accessing information.
• Additionally, storing a memory back in its place, is an mTOR driven response. If mTOR is turned on all the time, that subtle response starts to fade away.
• All of the symptoms, though, lead back to glucose management.

[00:12:07]   An interesting analogy on genetics follows.

[00:13:25]   Resveratrol

• It is a compound that is found in the skin of red grapes.
• Animal studies showed that it protects against free radicals.
• It stimulates autophagy (the body's way of cleaning out damaged cells, in order to regenerate newer, healthier cells)
• It protects from DNA damage due to the sirtuin (a family of signaling proteins involved in metabolic regulation) activation.
• It ameliorates certain aspects of conditions of age-related disease like:
  • metabolic disorders,
  • type two diabetes,
  • cancer,
  • neurocognitive diseases,
  • and cardiovascular disease.
• It boosts mitochondrial function.
• It improves inflammation.

[00:14:28]   A study in 2010/2011 showed that Resveratrol outperformed Metformin during a mg for mg comparison. And Resveratrol does not shut off mTOR.

[00:21:35]   NAD (nicotinamide adenine dinucleotide) is a crucial coenzyme in the body, in charge of hundreds of cellular processes.

• It is necessary to turn food into energy.
• Remediates inflammation.
• Assists in mitochondrial health.
• Activates autophagy.
• Activates different longevity pathways.
• Affects sirtuin production.

[00:21:52]   Several studies show that the body prefers to produce NAD on demand from precursors. NMN (nicotinamide mono nucleotide) is a direct precursor to NAD. See link below for an awesome product combining NMN and Resveratrol.

[00:22:31]   Sirtuins are a family of signaling proteins involved in metabolic regulation. They are important for various reasons:

• they help repair the DNA
• they are epigenetic regulators and help to turn on and off different expression of different genes
• when distracted, this can, this can lead to DNA damage accumulation, loss of identity for cells increased, or accelerated cellular aging.

[00:24:05]   NAD diminishes with age and therefore sirtuin production as well

[00:35:51]  Some people experience an energy boost after a couple of weeks of using NMN.

[00:39:37]   A study done on mice from the age of 5 weeks to 17 weeks given NMN supplementation, showed the following: 

• lower body weight
• better insulin sensitivity
• more energy
• improved mitochondrial function
• better immune function
• improved eyesight, and
• activation of longevity genes, instead of activation of aging genes

[00:40:52]   A 10-week study on pre-diabetic woman with 10 weeks of NMN supplementation 250 mg per day, showed that after 10 weeks these women had better insulin sensitivity in their muscle.

[00:41:17]   The second study was not peer reviewed. It was in 22 healthy, older adult, Japanese men. After 12 weeks of supplementation at 250 mg NMN per day, their muscle function, and measures of mobility, like gait speed and grip strength, improved.

[00:42:02]   Human studies also showed that Resveratrol mitigates oxidative stress and improves inflammation.

[00:49:16]   A 6-week study on amateur runners showed amazing results by increasing their aerobic capacity after consuming 600 – 1200 mg of NMN.

[00:49:46]   Another interesting analogy explaining the groundbreaking findings around VO2 Max.

[00:52:36]   Jaqueline shares some fascinating facts regarding the research she is doing pertaining to music therapy and its impacts on dementia.

VERSO

www.shrnetwork.biz/verso

and use the code SHR, you'll save 20% per bottle.