Scientists Identify Gut-derived Metabolites that Play a Role in Neurodegeneration

[00:03:43]   You said how exciting it is to be a neurologist and talking about diet tell, me why?

• In general patients feel devastated after they receive a diagnosis and there is a sense of not being in charge of your own life so:
  • They want to do something about it.
  • They want to be empowered.
  • They want to know if they are eating right.
  • They want to know if their habits are going to affect the disease.
  • And if there is anything they can do to change it.
• It becomes critical to try to understand a number of healthy behaviors than can be promoted.
• It is important to really understand how diet affects the organism.
• It is important to know that Vitamin D is critical for our health.
• By providing the multiple sclerosis society a number of guidelines, they can really make decisions for themselves.
• It’s a lifestyle intervention overall.

[00:06:47]   What required this study to be done?

• Patrizia Casaccia follows with an explanation of toxic ceramides (bad fats) that were discovered in the cerebrospinal fluid of patients leading to this fascinating study.
• She goes on to explain how the ceramides enters the blood brain barrier.

[00:13:33]   What is the blood-brain barrier, and can it be repaired once it has a leak?

• Blood vessels and cells called astrocytes form a tight junction
• There are substances and compounds that create gaps in this junction so that the blood can pass.

[00:14:21]   We have this same phenomenon in the gut, could it be that the junctions in the gut and the junctions in the brain share some similarities?

• There are some similarities but there are also enough differences.
• There are a lot of cellular specificity and the lack of specific chemical pathway that render the 2 systems different.

[00:15:05]   A thought-provoking find regarding leaky gut, leaky barrier and auto immune illnesses are explained.

[00:22:38]   Could the ceramides that women put on their face be absorbed into the skin?

• It depends on the type ceramides.
• There are ceramides that are helpful and some that are not extremely helpful.
• It would not be the first time that cosmetics contain potential toxins.

[00:23:18]   There is a big initiative by the National Institute of Health to understand the role

of environmental toxicants on the nervous system.

[00:31:51]   Tell me about the metabolites that you discovered in your research?

• We identified three major metabolites and they are called paracrystal sulphate, indoxyl sulphate and phenyl acetyl glutamine.
• An explanation about the way the study was conducted, ensues.
• These are products of amino acid metabolism.
• Tyrosine and Tryptophan.
• Ongoing studies are trying to understand why some people metabolize these in a different way.

[00:37:25]   You said earlier there seems to be a link between processed food and flare-ups of multiple sclerosis maybe the  answer is to eat real food?

• Absolutely! there is no question.
• Real food is one of the first recommendations.
• Hopefully without a lot of additives.
• Food that you cook yourself.
• Preferably organic.

[00:38:00]   Must listen - the explanation about organic food and glyphosate!!

[00:46:54]   Are there any standards that we can apply, lifestyle changes people can make to help?

• The most important criterion is, there is not 1 standard diet for all.
• It requires some self-study.
• There is current evidence on the different types of diets reviewed by a group of analysts, on the National Multiple Sclerosis Society website.

[00:47:57]   Another riveting discussion on healthy foods follows.

[00:50:50]   There are people out there literally mapping the microbiome of people with multiple sclerosis at this point in time. Dr Casaccia explains further.

[00:53:30]   Should people who think they have a predisposition to MS or even other neurological disorders have their doctor checking for blood levels of ceramides?

• Dr Casaccia answers this with yet another fascinating story on a study that has been done by a scientist in Australia.

[00:57:23]   The interview ends here with a discussion on the possible impact coffee would have in this case.

Patrizia Casaccia, MD, PhD

Dr. Patrizia Casaccia is Professor of Neuroscience, Genetics and Genomics; and Neurology. Dr. Casaccia is the Chief of the Center of Excellence for Myelin Repair at the Friedman Brain Institute at Mount Sinai School of Medicine.

She received her medical degree with Honors from the University of Rome, and a PhD degree in Neurobiology from State University of New York (SUNY) Health and Science Center Brooklyn.  She then trained at Cornell Weill Medical Center in New York and at the Skirball Institute for Molecular Medicine at NYU.

Dr. Casaccia’s work adopts molecular and cellular techniques to find new therapies for multiple sclerosis. Her work includes translational research in regenerative and personalized medicine.  The laboratory focuses on myelin repair with a special emphasis on the effect of aging and gender differences. In addition, her research addresses the mechanism of neuronal damage in patients with MS leading to novel screening for the discovery of new therapies to protect the neurons and replace damaged myelin.

The new methodologies leading to personalized medicine include the generation of neural stem cells from patients' skin, and the analysis of DNA and RNA from the blood of multiple sclerosis patients.  Her work is funded by grants from the National Institute for Neurological Disorders and Stroke and by the National Multiple Sclerosis Society.

Sun Damage? Copper peptides Can Repair & Protect Your Skin

[01:05:46]   How can you enjoy the healthy qualities of the sun without getting the skin damage?

• Use Melanotan – prepares your skin days before you go into the sun (i.e., travelling)
• Use GHK-Cu (glycyl-l-histidyl-l-lysine) – initiates the repair process faster
  • In fibroblasts, which are the stemish sort of cells in our skin that when they're treated with GHK-Cu they take on a more youthful more stem cell like shape
  • It has a cuboidal very straight sided shape instead of this kind of flattened out more aged cell shape and these are more youthful even if they're exposed to radiation.
  • Use GHK-Cu as a repair as opposed to a sunscreen.
  • It’s a protection in a way that it allows your cells to go through DNA repair.

[01:08:23]   Use GHK-Cu when you know you are going to be exposed to any radiation, i.e., travelling on an airplane.

[01:08:51]   Did you have any sun damage before you started to use the topical GHK-Cu?

• Yes, I have been using it for 2 years and it has made a huge difference.
• I apply it underneath sunscreen.
• My skin looks better now than 10 years ago.

[01:09:52]   Melanotan 2 was invented by Arizona State University to pre-treat your skin before going out in the sun.

[01:11:45]   What's the difference between the serum and the moisturizer?

• The serum has the greatest concentration of GHK-Cu (500mg).
• It also contains kelp and hyaluronic acid and other very helpful ingredients.
• The moisturizer contains natural oils combined with the GHK-Cu (avocado oil, sweet almond oil and kukui nut oil from Hawaii.

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Suzanne Ferree Turner, MD, FAARM, FSSRP

"I remember coming out of my first exposure to functional medicine like the scales had fallen from my eyes, and I could never unknow what I now knew. But I had very little idea how to apply all that I had learned to the patients in my practice. I have spent thousands of dollars on postgraduate schooling to become arguably the most sought-after provider of cellular, longevity and performance medicine around. I am ready to share that knowledge with you.

While in residency, I achieved the Society of Teachers of Medicine (STFM) Award, which like the Medal of Honor is only given when the person demonstrates exceptional performance. I am board certified in functional medicine through the American Academy of Anti-Aging and Regenerative Medicine (A4M); this is the pinnacle of education in longevity and regenerative medicine. I also studied post fellowship and received advanced certification in Endocrinology, then I studied pellet therapy through Dr. Rebecca Glazer and BioTe, the leading researchers in pellet therapy for hormone replacement. I was in the first class to graduate the Peptide Certification through A4M, and due to my passion and mastery of the science of cellular medicine, I was selected as part of their faculty for all subsequent peptide certification courses. In the last 7 years, I’ve participated in Masterminds through the International Peptide Society (IPS) and Seeds Scientific Research and Performance (SSRP). I have been honored to serve as faculty for several leading organizations in the cellular, performance and longevity space, including IPS, the American College of Advancements in Medicine (ACAM), BioTe and SSRP. My popularity on SuperHumanRadio’s PepTalk, Jay Campbell, and Biohacking SuperHuman Performance surprised even me and has resulted in repeated invitations. As you can see, my passions are teaching and learning."

Debbi Barber

Debbi's journey started with her doctor who is double board-certified in both Family Medicine and AntiAging and Regenerative Medicine. Her question was a simple one... what do you recommend for crepey skin? But her Doctor's answer was a game changer! GHK-Cu (Copper peptides), the most exciting new weapon in the fight against aging skin. It was not a quick fix that temporarily plumps up your face. Debbi learned in her research that Copper peptides work by invigorating aging stem cells and use the body’s own systems to get rid of damaged and worn-out proteins. This process facilitates true skin repair and renewal. 

From there, she worked at identifying the best and most impactful ingredients to complement Copper peptides, but they had to be all-natural, non-toxic, and safe for sensitive skin. She made sure to include the best ingredients for healthy skin... Coconut Oil, Avocado Oil, Kelp Extract, Shea Butter, Vitamin E, Hyaluronic Acid, and Silk Amino Acids just to name a few. After working with specialists in the organic lab, she came up with the perfect formulas, and Restoracell was born.