Dr. Mikhail Blagosklonny
Emerging science has identified a specific bad actor as the common denominator target to halt and even reverse aging. Reversing aging takes along with it many age-related diseases which can be eliminated along with aging reversal.
No one has done more to pioneer this science than Dr. Mikhail Blagosklonny. Today he will explain how to eliminate the accumulation of senescent cells in humans and open the door of information to clinicians and general public that will eventually end the suffering of aging and age-related disease. We are embarking on a very exciting time in medical science.
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NOTE: Due to the guest's accent this transcript is likely to have numerous errors. The Podcast is probably the best source for this particualr interview.
[00:00:00] Hey, hey, welcome back to another episode of superhuman radio many of you Avid listeners of the show asking yourself. Why is Carl on the air on Friday? You know, this is traditionally my day off from the show. But when a scientist like dr. McHale blackish glowny says he's available on a Friday you do a show.
[00:00:52] Dr. Black is gone. He was on my show. I want to say back in 2016 giving us a peek into what the future of [00:01:00] anti-aging could be and he has since made great advances in this area. So we're going to be talking about that today. How you doing? Dr. Boguslaw knee?
[00:01:12] No sound huh? That's odd. Let's see Misha. Can you hear me? Yes, wonderful. It works. Okay, ever since Microsoft bought Skype. We've had nothing but issues with it. So anyway, I will edit all that other stuff out. Welcome to the show. Dr. Bikel blackish cloney. How are. I'm fine. I know so dr.
[00:01:37] Black is going he doesn't really like to do interviews. The truth of the matter is no I will like what's that? Yeah, I will like right but we're going to we're going to do this and it's going to be a lot of fun and people going to learn a lot of stuff because what you have to talk about is very very important before we start getting into the discussion.
[00:01:57] I want to I want to read something so that [00:02:00] people in this audience know who dr. Black is Colonia is he is currently editor-in-chief of the journal aging cell cycle and Uncle Target. He is also the associate editor of cancer biology in therapy. He has spent his career originally studying cancer and somehow that segwayed into anti-aging.
[00:02:24] How did that happen? How did you go from studying cancer to looking at modalities to treat anti-aging is there what's the overlap between Cancer and anti-aging? I was studying. Anti-cancer drug tropomyosin. Yeah, and we found that. This drug May in certain conditions prevent senescence of cancer cells.
[00:03:00] [00:02:59] So then I was thinking about this phenomenon and. I got some fear area which was much broader and why they're so we tested them in normal cells normal and we found that the parmesan suppress senescence aging of cells at the beginning. I was thinking about this. Still not over here. So basically we were thinking about creating anti-aging cream for skin.
[00:03:43] Yes. We even contacted one Cosmetic Company mm, but they will not interested. Please said we don't need real drug in [00:04:00] a cream, right? And you know, it's interesting because the two current areas of treatment we dealing with anti-aging both come from cancer interestingly because I did a show not too long ago with the gentleman a scientist.
[00:04:18] I can't remember his name, but in rodents they gave them to Saturn it which is a it was a chemo. Drug, and they showed that they could eliminate senescent cells and so let's talk about senescent cells because there's a lot this is the new Target when we talk about anti-aging senescent cells seem to be the lowest common denominator in what we consider aging and age-related diseases.
[00:04:47] So what's the difference between a senescent cell and acquiescence cell or normalcy? So normally are not dividing cells supposed to be [00:05:00] questioned. So they acquired they don't grow in size. They don't click rate. They can be activated when needed in the organism by signals garments. Everything is fine.
[00:05:16] But when. Nutrient sensing pathway, which is called mtor. Is activated in non-dividing cells cells become senescent.
[00:05:40] In that organism. It happens very slowly. So they try to grow in size because they are not dividing and they become very stressed. They are functions increase and when they are functions increase they become damaging to the [00:06:00] organism even on the distance, for example. Leave us cells can produce more lipoproteins or fat cells become hypertrophic and they also secrete
[00:06:22] repeats or platelets become very prone for aggregation at the even smooth muscle cells. You know them I'll tell you is also a pro become prone to contraction so instead so that's like stiff that we think of aging and stiffness of the muscles. So that could be a contributor to that in other words.
[00:06:53] So basically this increased functions of cells [00:07:00] damaged. Human body and trinamool budget for example causing atherosclerosis and thrombosis and infarction or stroke so we can connect activation of mtor. in cells to diseases and finally to death. So if to use rapamycin, which is very selective inhibitor of mtor.
[00:07:39] And this is in a building with no wait, I want to I want to make sure that I cuz I want to pose a question that you can answer with this right now. So there there there is one group in the anti aging community that wants to turn em tore off all the time and we know this isn't good because then protein synthesis stops and muscle wasting could [00:08:00] begin and then.
[00:08:02] There's another group. I believe like yourself that feels that selectively turning mtor off is a better way because you can you can achieve reducing the accumulation of senescent cells at the same time allow the body to continue to repair muscle and function. Is that correct? Is that a correct assumption?
[00:08:24] Right. I just want to add that currently. Several scientists including mean I think that the best way to give rapamycin is intermittent, for example, relatively high dose once a week. It has long Half-Life in the organism. So if to take. It's relatively high [00:09:00] dose then by the end of the week it will be almost 0 so at the time organism can recover recover.
[00:09:15] Okay, and not only that cells become much more sensitive to. He's got will Jiggle It will out regulation so they will even. You spawned better into muscles would be increased many people several people contacted me here the unfortunately doing self treatment with the bombers and they. Did the can exercise better one person emailed me that he can run marathon [00:10:00] faster than last year.
[00:10:02] So he and that is that because senescent cells it's so there's some evidence that senescent cells produce. A harmful chemical that poisoned the cells around them. Is that because when you eradicate senescent cells all the cells around function better. Yes. But what about my Senate really doesn't get educated senescent cells in case two activities one it prevents it prevents transition from questions to senescence because I'm poor.
[00:10:37] Is required for this and second even these cells become a religious innocent. It decreases function. So all these chemicals that they produce and secrete this is because they are hyper functional. So if it's these [00:11:00] two effects if to talk about signal latex, it's. Another group of drugs, which is recently developed.
[00:11:11] They kill senescent cells. Yes, I do. So it's like two different mechanisms. Okay what I want I want to stop you there because I want to make sure that everybody's getting getting all of this. So this some Center Lennox can actually turn senescent cells back into quiescent cells. Is that what you're saying?
[00:11:34] No, actually they just supposed to kill kill them you'll senescence. Okay, so so just wrap a myosin. I understand the rapper - and keeps quiescent cells from becoming senescent, but does it also kill the senescent cells over time? Oh no over time. We just make it suppress it suppresses them. It's oppressive.
[00:11:59] [00:12:00] Yes, yes make them more question right not completely here, but more okay. So basically the bombers them Works mostly. Yes very welcome. Okay. Alright, so and I want to talk about Center latex as a group little bit later in the show, but I want to stay with rapamycin first because I want to make sure that everybody understands.
[00:12:28] They complete capacity of what rap of myosin does and so on so there I know of a scientist in California that's working with dogs. And he's giving the dogs rapamycin doses continuously similar to that that would be given to someone for anti-rejection of an organ transplant. And this is producing some bad outcomes and you're proposing intermittent use.
[00:12:56] So that mtor cans to continue to [00:13:00] function and and rebuild muscle and and and so on and he go ahead if you want to cough. I just killed your microphone so that that mtor can continue to rebuild muscle and the body can function properly but there are some people out there who think that any dose of rapamycin could be.
[00:13:19] Disadvantageous because it's suppressing the immune system. Can you address immune system suppression with intermittent rapamycin as you propose and some of your papers do we have to worry about we have to stay home that day so we don't catch a cold, you know, okay, so. My son was with you unlucky because 20 years ago one company labeled.
[00:13:49] It is immunosuppressant immunosuppressants, but it is not if they would label it anti-inflammatory drug, which prevents secretion of [00:14:00] inflammation cytokines. It would be so perfect to the public so. What about my son doesn't course consists prevents cancer in animals and humans. It prevents infections and even treat viral infections in humans and animals.
[00:14:23] It was recently for that. But Apollo took another look of rapamycin even Alamos, but it's basically the same as rapamycin just it has a pattern so it's now developed increase but the nation in the world. People against people for example and also decrease [00:15:00] infections. So there is no evidence actually that it's increases infections some it was just warning from empty 20 years ago and it says exactly like that it me.
[00:15:19] No, no, it will doesn't say this. It causes immunosuppression and immunosuppression may increase infections. So right was so no one actually shows. I want I want to repeat this for the audience to if in fact that was true that it was immunosuppressant. It wouldn't prevent infections. That's that's a very very logical.
[00:15:45] Aspect that kind of dispels the notion that it is immunosuppressant. Yeah it well. It's used in renal transplant patients, for example, [00:16:00] but it doesn't it's used together with real immunosuppressants like cyclosporine for example or glucocorticoids to get them. It's used in very high doses every day for many years.
[00:16:19] So some kind of actions in this difference can be increased some kind it was already phone decreased in contrast special some viral infections so different effects, but when we are talking. One effect of rapamycin in relatively healthy people. There is no evidence that you think is the simple actions, especially if not to [00:17:00] give it in such high doses every day for many years like in organ transplant reference or.
[00:17:10] Okay bleep actions anyway, because you have too many studies. They have no Placebo control. So everything assigned to repair my son for example, but when Placebo control was done sometimes turn out the placebo causes more scientific The Cremation interesting. Yes. Yeah, so without Placebo So currently.
[00:17:44] Investigation of rapamycin he has anti-aging
[00:17:53] drug doesn't reveal this terrible side effects.
[00:18:00] [00:18:04] Yes in contrast for example rapamycin is the best preventive agent against cancer in mice. It's prevents comes in all models because can see is it related diseases? In humans actually renal transplant patients who were taking the pain medicine they could have less incidence of cancer it you can call it side effect because it was given for another purpose but say effect was less.
[00:18:47] So so dr. Thomas Seyfried wrote a profound book a few years ago. He was on my show called cancer as a metabolic disease where he shows definitively that all cancer really starts [00:19:00] in the mitochondria when the mitochondria become goes to anaerobic respiration. So does rapamycin there any evidence of scientific evidence that shows that rapamycin has a direct effect on mitochondria.
[00:19:14] Because indirect effect indirect. So basically it's increased respiration mitochondrial in decrease production of lactic acid police's but it's very interesting that rapamycin could be you. In a very unusual applications, for example, it just hypothesis because it's increased relative decrease lactic acid.
[00:19:43] Maybe it could be used for birthday people looking for women's sports performance. You could be a it could be a performance-enhancing. Hey, babe, it will be legal. Of course. I don't know right? Yeah, I know [00:20:00] they'll out Lord right away anything that gives Youmans The Edge they outlawed right away.
[00:20:03] So so some people out there like myself a huge fans of intermittent fasting and once every couple months. I will Fast for. 72 hours and there's a people out there who was saying but why take rapamycin once a week when you could just fast for 24 hours and because fasting has been shown to suppress mtor, what is rapamycin doing differently than just just fasting?
[00:20:31] Okay. So first of all, it's much easier to use the term I sent into past for most people, right? Right compliance is obviously an issue so that's good. Okay, so second. In fact is a little bit different. It was from that in Old mice, you know [00:21:00] fasting and calorie restriction fasting with Superior doesn't really inhibit.
[00:21:09] Into or like it. That's in young animals. It is actually usually a calorie restriction work better for problem time. but rapamycin works always second
[00:21:34] intermittent fasting have some. Will soak up some side effects, of course, for example, it can increase anxiety third. There are some tissue specificity. Okay, split the tissue specificity. [00:22:00] Okay. Yes all of this for example myson inhibit. Into or differently in different tissues. Yes, and unfortunately, we don't know it very well, but we know and this is actually why recent studies showed that the best anti-aging effect went to give.
[00:22:32] Lydia quite a few duels in animals to reach very high peak of rapamycin and then it goes down but Peak is important. So finally finally rapamycin can be combined with into we passed them, especially because. [00:23:00] I'll go report mice and decrease weight. It doesn't do it extremely soundly, so in any way some Diet could be beneficial in combination.
[00:23:20] So intermittent fasting, I think it's. Lady good technique, but probably less powerful and also. It may be combined with the points rapamycin that makes perfect sense. What I want to do right now is I want to take a quick commercial break. But before I go into the break, there are a lot of Physicians and clinicians that listen to this show and the reality is that you are looking to train Physicians to your protocol, which we're going to talk more about as we talk about Center latex.
[00:23:59] And [00:24:00] how some things work well with rapamycin, how can someone reach you if they're interested in learning more about how to use rapamycin with their patients for anti-aging? Okay the best way to reach me by email, for example. My last name blood gets lonely yet that apple looks at publix.com republics.
[00:24:27] Okay Coach, but it's black is cloning it BL a Geo skl Och and NY a Trapper logs, which is our APA L OG s.com. Yes, okay, I we're gonna take a quick commercial break. We'll be right back with. Dr. Miguel blackish glowny. Don't turn that dial.
[00:24:52] Welcome back. We're talking with dr. Miguel blackish glowny were talking about rapamycin as an anti-aging drug. I'm really [00:25:00] excited about this and I'll tell you why. Dr. Blackest clone. He has worked very very closely with a physician in New York. Those of you live in New York. Dr. Alan Green has a medical practice in New York where he has been treating patients with rapamycin.
[00:25:15] For close to three years now along with some other set of latex and dietary protocols reducing Advanced glycation end product production and so on. And he's had marvelous success. In fact, I plan on visiting. Dr. Greene probably end of February early March in order to become one of his patients and start using rapamycin.
[00:25:36] But with that being said, so wrap a myosin is actually a as we talked about. Dr. Greene is is using it, you know of him you in fact told me about him. What is he see with his patients when they are using rapamycin according to the protocol that you create an I think he does weekly or even just by a bi-monthly he just does it [00:26:00] twice a twice a month.
[00:26:02] What do people start to notice about themselves?
[00:26:10] Dr. Greene here treated already 200 200. I'm sorry. I said 300. I'm sorry 200. Okay. So and some of them come in from New Zealand Australia all over the world. So it's look like that people need two more such Kleenex. Yes, and we have been part and part of my part of my mission. So everybody knows this.
[00:26:40] So the Physicians listening to the show today part of my mission is to spread the word of This research because we need Physicians everywhere in their current medical practices to start to pay attention to the therapies promoted by dr. Blackish glowny. And here's why dr. Greene has had great success [00:27:00] with these two hundred patients over the past.
[00:27:01] I think two or three years now, right? Right, right. Well, I'm probably not supposed to talk about his results because he didn't. make it Power public yet, but I know that he's very happy with the treatment of this to Country it refunds and. He is using rapamycin together with other conventional drugs, which also prevent diseases for example, aspirin and lisinopril.
[00:27:50] It's such a hype hypertensive drug metformin so and well, he [00:28:00] mentioned that it's look like. He has more problems with Aspirin that will recognize some interesting. Yeah. I would encourage him to publish his results. Yeah, okay. What about you? Have you seen the effects on humans using rapamycin for anti-aging have you seen because of a moment ago you talked about someone who said hey, I can run faster than I could a year ago.
[00:28:34] What do people notice if they start rapamycin therapy? Do they look younger? Do they feel younger? Do they sleep better do age-related diseases start to subside or can you actually not even talk about that at this input at this point? Probably but people who each to me. They usually asking about doses.
[00:28:59] I [00:29:00] was going to get to that next. Yeah, I was going to ask that next good. We will really ask I am. They can these doors. Is it an apple food take more because I have no side effects, but I'm not sure that I reach therapeutic effect, right so
[00:29:24] well. I could not give such advices. We need really doctors who will work with this preference and monitor and do all the right things. Yes. It would be Reckless just to edit and I was going to ask you. What's the dose I've heard. And read some papers where it was as little as six or seven milligrams a day on the days that you take it and I don't know that that's a big dose or a small dose of rapamycin, but I've read some stuff out there.
[00:29:59] There is other [00:30:00] information out there that promotes your approach quite frankly. Yeah stole some people in general take maybe less. Then we currently think according to animal studies right? It's usually between 1 milligram and 5 milligram period week and but one piece and he was taking rapamycin due to his Beauty fashion.
[00:30:37] Because credited with the affection you felt it was there is no treatment for this rare disease. So he was taking like 20 milligram every day for several weeks 30. Did you say 13 milligrams? 2020? Oh, wow, okay. [00:31:00] You can't and he hits side to side effects, of course, so he was bothered it mostly with painful mucositis in his mouth because my son in high chronic disease in such it's decreased cell proliferation.
[00:31:23] So it's working like. Reversible in these doses our regime like reversible set aesthetic. It doesn't kill cells but the proliferate so slowly that people have conquers Aegis, for example. Yes, so. You can say about what you've kind of answered the question indirectly that you know, like one two, three milligrams once a week [00:32:00] or in dr.
[00:32:00] Greene's protocol once every other week may be adequate to to see the results. And obviously that makes perfect sense. If you take too much it's going to slow cell turnover completely because you you're suppressing cellular turnover entirely at that point in time. And so yeah, it's actually what do you understand about?
[00:32:20] Won't healings. So if to take high doses chronically everyday of course won't helium will be impaired because cells need to proliferate what it's look like that intermittent Administration could even improve wound healing because. Sales began in the presence of optimization cells become more sensitive to Signal Ian here, but they cannot respond but more sensitive then if you [00:33:00] stop rapamycin, then they can respond much better one physiological needs and to.
[00:33:11] Participate important helium so the most important. I think while using rapamycin is to avoid side effects, right? Don't lock the lowest effective dose. The lowest effective dose is what you're striving for. I would say a little bit differently. It could be a single doses. For example your video Whatever once a week or but yes Kyle is the person want to deliberate [00:34:00] I mean.
[00:34:03] Yes, hi. Is limited by side effects rifle or psychological for example Isn't So for us so it should not be forced on the patient. So far, there's no observations of toxicity, okay? Single doses there are several example of attempts to commit suicide with their permission. For example, one woman 18 years old.
[00:34:46] She took 103 tablets when he can eat a peach tablet is how many milligrams one milligram so stricken a hundred three single dose hundred three milligrams of rapamycin to try [00:35:00] to kill herself. Yes, so the only hear what was observable is slight increase. In health the role which then remained to normal, so an increase in cholesterol.
[00:35:16] Yes, because the pain is an increase this Loop lipolysis infect cells. I got you. Wow you so what you're saying is it could be a fat loss drug if used for anti-aging it could stimulate lipolysis on the days that you take it. So you probably would want to take it and then go exercise later on that day.
[00:35:39] Exactly. This is what I was thinking too long ago because this. lipids in the blood. The food beer you somehow because at the same time the promise and [00:36:00] prevents use of this pretty acids in arterial wall. So it prevents lateral lateral sclerosis right by the way about even funeral after sclerosis all these data accidental for example.
[00:36:21] There are it upon my son. contributor limos eluting stents. for coronary arteries and to prevent this stenosis after. Appear a fan but these stents cost a lot. I think maybe 500 5000 right? So in some countries we decided [00:37:00] to use just bear stand with our Ally nothing in them. Right like it was before right, but but to give proper mice and Piero's and it works so it shows the formation Piero's decreases.
[00:37:19] Just to know is just so I throw sclerosis is been implicated to occur as a result of of inflammation in the intima of of the of the the arteries. And so and you said earlier that rapamycin has an anti-inflammatory effect, right? So this makes sense, right and don't say it's pretty well. Senescence for example macrophages deeply cultural Rescuers.
[00:37:51] They become foam cells from cells that right. Yes that and that's when they get too old. They become foam cells right? Boom Celsius [00:38:00] example of senescent mammography and also repair. My stomach is a lot of other effects. Why am I telling this story with stems is because it's known well that rapamycin decreases previous a lateral sclerosis in mice.
[00:38:30] But we have also did in humans which was not done for that purpose. It was just because stands very expensive. Right. Now I make sense. So they found out by accident that it prevents arthrosclerosis. Now does rapamycin affect the phenomenon of autophagy? We know now that etapa g has a very important role in removing metabolic waste from the body and fasting stimulate saw [00:39:00] topology it you do you think that there's any link between rapamycin therapy and and stimulating or topology.
[00:39:07] Yes. Mtor Target of rapamycin is them regulator of metabolism including Auto fridge eating increases sort of each? Yeah, because when mtor is reduced or topology is elevated, right? Well, it's reduced its elevated because it's like. the seal organism cell. Feels that it's past him. right got nutrients activate mtor this by actually idct accelerate engine but rapamycin decrease some tour and stimulates out of Egypt because cell.
[00:40:00] [00:39:59] Just saved it to use all this abnormal proteins because of cells T-cells think is starvation. So and what is interesting also that? It's unrelated to each him, of course, but out of phrygia is useful for sale. To fight somewhere us' to wait for the cell to do what so his defense out of here is defense against viruses also.
[00:40:39] Oh, yes. Okay. Yeah prevents. What does it it kills viruses? Right? It's a yes. So let us just write to inhibit out approaches some kind of viruses like here Chris virus and everything. Yeah, so about my son [00:41:00] can decrease viral infections. It's not through immunity. But throughout the preacher interesting.
[00:41:11] Wow, that's very very interesting. I want I want to is there anything else you want to tell the audience about rapamycin because I want to take the next break and when we come back I want to talk about Sin a let expression. As a category of drugs repurposing existing drugs because they seem to play a role in this process of anti-aging anything else.
[00:41:33] You want to tell the audience about rapamycin therapy. So basically it's also deep your person about my son for anti-aging and.
[00:41:49] repair my sand castles analogs. Like if you're a demos, which is produced sold by. [00:42:00] Novartis but it's extremely expensive you better you must even repair. My son is still very expensive because it's sold by one company Faisal in United States.
[00:42:20] so. Some scientists and Physicians starting take the permission one is different told me that he's taken it upon my son, but he is not ready yet to give it to patients like doctor Gilliam is doing
[00:42:45] yes. We need Physicians enthusiastic. Interested in anti-vegan Philippine. Yeah, we need more Physicians. I wish I was a physician in Louisville [00:43:00] Kentucky that I could get to follow your protocol and treat me. I don't mind going to New York. I have family that still live in New York. So I'll get to see them but dr.
[00:43:10] Greene seems to be the only physician in America today that is that is doing this or are there other Physicians out there? Dr. Blog is cool. Well, I don't know really. Dr. Grill Moon front me to me that some kids difference approach him, but I don't know details.
[00:43:35] And one patient from Florida for example emailed me doing no. Such positions including the because he cannot take airplane his spine problems. So whatever to go to dr. Greene, so it's look like people [00:44:00] desperately want such is difference locally Wilson, right? You know, it's really interesting because Florida.
[00:44:13] Is so many elderly people live in Florida that that is where you would imagine would be the mecca, you know of anti-aging and this would have been something that Physicians would be looking for but I have a funny feeling that not enough Physicians know it's not a matter of them not wanting to do it.
[00:44:32] I don't think enough people know right exactly. Yes because. Saying just for statue and inclusions study rapamycin even in humans. They published in scientific journals, not MediCal journals, it would be. I think I prefer it to publish and I [00:45:00] will do this to publish something in medical journals.
[00:45:08] Yes. Yeah, I want to take our last commercial break and when we come back, I want to talk about Sin analytics. This is something we've done individual shows about I wanted and I want to talk about metformin. I am still not a believer in metformin and I'll explain why I actually have a big bottle of it at home.
[00:45:27] And I don't use it because I'm still on the fence about metformin. So maybe you can enlighten me about metformin we're talking with dr. Miguel blackish glowny his email address if you are a clinician. And you want to become educated in this therapy for your patience and for yourself? Because if you're just like your patients you're getting older the email address is blackish cloney BL a Geo skl Och and NY a trap a logs.com reach out [00:46:00] to dr.
[00:46:00] Black is lonely because he is looking for people who want to practice this type of medicine. Stay tuned. We'll be right back. Welcome back to super human radio with talking with dr. Bikel blackish glowny, you know, there's a lot of stuff out there about anti-aging there's NAD, you know, I was just having this conversation with the Eliza my girlfriend, you know, she said, what do you think about NAD I said, you know, I remember when life extension Foundation first started producing a magazine and they.
[00:46:34] With basing from a one study done on rodents where they switch the pineal glands from old rodents to Young rodents. They said oh melatonin. It's the anti-aging drug of the future and it didn't really keep people from aging then DHEA. Oh, well DHEA drops as you age. So taking DHA will keep you young forever that never happened and I kind of feel that [00:47:00] way about a lot of things that we see.
[00:47:02] That promised anti-aging effects. I don't feel that way about this. This is I feel like the science is very sound on the idea that the lowest common denominator in aging and age-related diseases are senescent cells. So I really believe in this and as a result, I believe that there are a lot of good Center Lennox that probably would work well in conjunction with rapamycin therapy, and I know one of them that a lot of people believe in is metformin my problem with metformin.
[00:47:36] Is it you taking a chronically and it's shutting off mtor in a chronic fashion and I am a big believer that the more muscle you carry also allows you to age better. So tell me about metformin. Do you really think it's great. Do you think there's a place for it? And what about the fact that it shuts off mtor on [00:48:00] indefinitely on going as long as you're taking it?
[00:48:04] Well in still culture. Foreman doesn't really. shut down into or so probably it's in organism because communication between different cell types.
[00:48:28] With Foreman increase lifespan in mice. Well, it's all think is supposed to increase lifespan in humans because it's prevents diabetes in some carbolic effects in mice much. Less than of rapamycin of course, but there are some referral [00:49:00] to combine the permission with for me and unfortunately, there are very few studies on this company from actually there is no one.
[00:49:11] Video studying. I am planning to do this I didn't do because I was sure that it will be done by others, right but somehow not really although scientists great about this combination and to drugs I use separate here but never was used together. It's what I mean, well has side effects for example only one.
[00:49:47] So what was the side effect on lemur on? Well, it's not really toxic [00:50:00] to all the types of has on the liver day. Yes hepatic hepatic issues. Yes, okay. Yeah, and also on the gut it seems to change the microbiome of the gut and we're not convinced yet that those changes are good. Right, but you see a net Farm in alone alone has much more beneficial effects then.
[00:50:27] side effects so you clearly much more. People taking metformin taken it upon myself, but let me let me ask you a question something a question. Dr. Black is Kalani. So I have no problem with blood sugar. In fact My fasting blood sugar in the morning. I check it weekly and I continue to check it is between 67 and 70 to I can go to the gym and train fasted I can fast for 72 hours and function.
[00:50:56] So I am already experiencing. [00:51:00] Fantastic blood sugar management for somebody like me what is metformin going to add that? I'm not experiencing already. You're right. So this combination of rapamycin with other six drugs conventional all of them extent life spent in any more simple Gene met Carmen.
[00:51:26] It's not necessary to take all six drops together time. It depends what your particular situation for example. If you're prone to increased blood pressure then this in a prio and beta blocker with the parmesan if you have tendency. To beat the Bullock changes like increase glucose the net [00:52:00] harm Ian if for lipoproteins then stay tuned for important.
[00:52:08] So this combination of seven tracks plus physical exercise. And stress I would dance unfortunately, we don't have really drugs, too. Because for example cortisol level it would be nice. But so some drugs could be excluded for example for you, maybe medical mean is not necessary at that point, but.
[00:52:50] When it is difference already use. Stuck him a speedy mm [00:53:00] with the blue cap. Plus I'm good the zoom tool Inhibitors likely scenario in combination and. You will get cold pool appeal it contains all these four ingredients. So and it was shown in many studies that the decrease the chances of to have infarction with stroke.
[00:53:32] So so it's like. becoming mainstream. But it is different don't realize that this combination is officially anti-aging and then I give it the not prescribing it for that reason. Yeah. Yeah, but it is take for basically late reason. So [00:54:00] to prevent death to prevent premature death, which is technically anti-aging.
[00:54:05] Yeah. So we suggest Next Step would be combined with this combination with the parmesan. There's one drug that I found very interesting that was on your list. And that was a phosphodiesterase 5 inhibitor, which was originally the goal was that it would lower blood pressure, but they found out that it didn't really lower blood pressure that well, but it gave every all the men in the study it great erections and it became Cialis and Viagra and so on.
[00:54:37] But you are a proponent. When would be appropriate for someone to take very low dose pde5 Inhibitors in conjunction with rapamycin. What are you looking for there? So gotten tear please since with prostate enlargement and some loose [00:55:00] the taken PGA. Hi. Keep it this like seriously Delia 5 milligram pills the right.
[00:55:10] We many not only studies and it's look like the most effective but it's also affect many other systems like pulmonary hypertension and so on when problem with this LT they have. Interesting life extension infection model organism the main problem or maybe not a problem that there are so many. other forms of pg5.
[00:55:53] in different dishes that. Current drugs, although the [00:56:00] low toxic. They don't affect most of the chiefest right thing is mm so much more studies could be done. So I so are you saying that that perhaps someday the development specifically maybe for anti-aging of a full-spectrum phosphodiesterase inhibitor at very low doses could be the answer.
[00:56:29] Maybe but you see current PG required for Inhibitors like Cialis because really low. Texas to video low side effects, it's taken by millions. And and especially the doses that are being promoted and I have I know a physician who promotes in men who have frequent urination and also enlarged [00:57:00] prostates 10 milligrams a day or five milligrams a day of.
[00:57:05] To dalla Phil, I guess that's Cialis and they they don't have frequent urinations. It does enhance their erect erectile function a little bit, but that's not the goal of it. It's just to get them to stop waking up five and ten times a night to urinate when their bladder is in full and it works so I know what you're talking about.
[00:57:26] I know a lot of Physicians are now doing this specifically for prostate problems. Hey, So it would be like second unexpected turn for pg5 to Inhibitors other other. What are there any tote? So is there anything that okay, so so rapper myosin will suppress. Senescent cells and make them act more like quiescent, but it doesn't turn them back [00:58:00] into quiescent and it also doesn't remove them from tissue.
[00:58:05] Is there anything out there that has been shown to actually clean out the current senescent cell accumulation in the human body. Yes, so. It's called genetics. This group of drugs. It's developed very recently. Although idea was for a long time because it's really simple idea rate to thing to kill it.
[00:58:39] They were found by drug screen. When you laboratorios screened for such drugs in cell culture. That's did Kill senescent cells but not question cells of the same type all of them. Turn out to be [00:59:00] one group several groups actually of anti-cancer drugs most of them. Experimental drugs is that is that like the dasatinib and quercetin study that was done on rodents this that's a sad and it is a chemo and when I read the research, it made me think well, maybe it kills the senescent cells because the senescent cells are not as robust as quiescent cells so they go first because they're weaker.
[00:59:32] I would say that mechanism really unclear. This is why. These drugs to Parliament by drug screen not by thinking right? Yeah, so.
[00:59:50] they target signal transaction Pathways. It's not drugs that traditional that damage DNA [01:00:00] or microtubules. It's not. Video hemotherapy like at the doxorubicin attack. So well this platino so they are clipped signal transduction sparklies some part with actually affect him to it also, so some of them could be.
[01:00:27] Indirect Inhibitors of mtor and at the same time Sinha latex, so everyone. Is very excited about synergetics butts in analytics really not ready to be used right now in humans because it's like next step. There are many reasons for their first of all, we have radium [01:01:00] selective two cell types. For example, they kill senescence cells walk.
[01:01:08] Adipocytes fat cells but one drug, but the same time it kills both senescent and not senescence cells open a data type so it could be side effects like open chickens drugs lately. So much more strategies should be done. Maybe they will be first used for some diseases are like including cancer prevention or lateral sclerosis because some of them.
[01:01:55] Kills kill foam [01:02:00] cells for example, right so it's like next step. I cannot imagine that somebody will well some of them. Maybe a non-prescription drugs. They could be used but especially experimental drugs. What bro? What role did quercetin you are you familiar with corset and quercetin the bioflavonoids.
[01:02:38] Hey, what what role did that have in the dasatinib study that showed the Saturn have been quercetin. Killed off and removed senescent cells from the rodents and now there's actually a human study being done in New York by a clinic and I've been communicating with them. They're going to come on the show sometime in 2019, once the [01:03:00] papers published.
[01:03:01] But what role did quercetin and of course it's in have in that whole effect, you know. Yeah. I don't know you've got because it. Because so many different promises so many studies showing completely different effects and mechanism targets some foods to pick some not it's. William clear what is going on with this compound and people taken it already.
[01:03:43] I just I started taking it a couple months ago because it it's an iron key later and it will help get iron out of the body and I am suffering from Iron overload right now, and I [01:04:00] actually have to do therapeutic phlebotomy. And I read a good study that shows that quercetin actually bonds to iron and helps carried out of the body.
[01:04:09] So I started taking it but then when I started reading some of this anti-aging stuff, I mean, I remember quite a long time ago. There's a science writer named Bill Sardi and he created a Resveratrol product and he included quercetin in there because he said that quercetin had. Benefits that's not why I take it but I do I have a kilo of it.
[01:04:31] I take 1/4 teaspoon every single morning now to help with my iron load and and I suspect that iron plays a profound effect because it bioaccumulates as we get older. I suspect that iron contributes to what we consider as the Aging phenotype quite frankly.
[01:04:54] It's possible. I never studied it right [01:05:00] this. so. But the experts in this but I want to give your email address again for those who are listening. The email address is blackish glowny at wrap a logs. And that's plural Rapa logs.com. And that's BL AG o s KL o NN y a trap a logs.com. If you are a physician or you have a friend who's a physician?
[01:05:29] Please have them reach out to dr. Blackest quality because really I've taken this on as a mission of my own. I'm actually sending this show off to several people after its produced because we do need more Physicians offering this as a therapy to their patients you now you told me 60 years old is a good age to start rapamycin therapy, right?
[01:05:53] That's like the no younger than. No, no, it could be started it [01:06:00] fortunate. Really. Yeah, because it's prevention. So yeah, but after development finished because. it will also slow down. Development of growth so it's not like starting from childhood. Of course. But it is but it is true that I read in several part of published papers about rapamycin therapy that it does extend life no matter how late you started.
[01:06:42] Now that doesn't mean if you wait to 80, you're going to live to be a hundred and fifty you may only live to be 90, but it is that an accurate statement that no matter when you started it does have a life-extending effect, right? It's correct. It's correct. [01:07:00] This is. it was actually surprising. That it could be started.
[01:07:08] Regulate probably because it's decrease functions of senescent cells,
[01:07:19] but I don't see any reason why not to start with it Fortune right at 40. That's you know, what you're right because 40 is really when the body starts to fall apart. It really is. Yeah. It's that. It's better to take it before. Yes, because for example Robinson May decrease question paralysis, and that's the example it says she deleted disease.
[01:07:57] And thus prevent [01:08:00] for example broken hip. Yes, great problem. Or elderly but if one already broken the permission will not help. Right, right. Yeah, so and some people died in their pocket. So I really would not say that it should be started from particularly. Like 16, right? Well, I'm 60. I'm going to start now.
[01:08:41] That's I could have started earlier had I known and that's the mission of the show to get people to know that this is available so that you can consider starting at a younger age around 40. And also as you said earlier, you know anything that reduces stress, and I know that. I put you under a lot of stress to come on [01:09:00] the show today.
[01:09:00] And and I appreciate you taking the time to do this. I really really do it was a pleasure talking to you all. Yeah, good good. I'm glad and I hope to be working with you in the near future. I am really going to work hard to get your message out there to more and more people because I want to be able to go to a doctor in Louisville, Kentucky.
[01:09:25] That will practice this type of therapy and I already have a doctor in mind that I'm going to send it to here in Louisville right away because he's a very very forward-leaning doctor and and I believe that he will be interested in learning more. So my goal is to get your inbox of your email filled up where you have nothing else time to do except reply to people's emails.
[01:09:48] That's my objective. And if I can do that the next couple months I will have succeeded. There you go. Dr. Black is cloney. Thank you so much for taking time to come on the show today. Thank you. [01:10:00] Okay, we'll talk soon. Okay. Okay. Okay, and that's it this special edition of supremum radio on a Friday.
[01:10:07] Enjoy it and I'll see you Monday. We've got lots of great shows plan next week. See you then.
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