Dr. Anthony G. Jay
Does epigenetics play a role in performance? If so what can we do to improve? Dr. Jay has launched a study to look at the effect of th red meat carnivore diet on markers of health and longevity and you can join in. An in depth discussion on the role of iron and diseases states.
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[00:00:00 Welcome back to another episode of superhuman radio. We're talking about epigenetics today. We talked about epigenetics really since about 2009 2010, but it's always been in the context of health and disease States, but we really haven't talked about epigenetics and performance and obviously. If epigenetics [00:01:00] have a role in Health and Longevity, then they must have a role in performance.
[00:01:07] We're going to get to the bottom of that today with dr. Anthony J and just a moment. Of course. I have to thank our title sponsor All American pharmaceutical and EFX sports right now. You get six of the top selling products absolutely free by going to superhuman radio Dot. Clicking the EFX Banner ad entering your name and address you will page five dollars and change for shipping but that truly shipping charge and you'll get six of their top-selling products.
[00:01:29] Absolutely free because dr. Jeff golini believes that no one should buy anything until they've tried it first. Welcome to the show. Dr. J. How you doing? Hey, thanks for having me Carl good so. You're really interesting cat. You've been doing a lot of interesting research in areas that we have talked about a lot on this show.
[00:01:53] You've done a lot of interesting research on the effects of estrogen on our population and the men in the population, [00:02:00] correct, but more recently. You're doing a lot of research into stem cells and epigenetics. But you seem to have discovered where this discussion intersects performance that makes you quite unique because most of the people talking about epigenetics and transgenerational inheritances.
[00:02:19] They're talking about the effects on disease States and health. What made you even think about the the relationship to Performance? Well, I mean, I definitely got into it because of the disease issues. I mean maybe not disease is the best word but you know suboptimal performance. I mean basically I got into epigenetics through estrogen or through artificial estrogen more specifically so like like for example BPA, right like we know bpa's bad, but most people don't realize bad because it acts like estrogen.
[00:02:51] And so the reason that's bad is because that can throw off your epigenetics. It changes the marks on top of your DNA and then of course, I went down [00:03:00] that rabbit hole and discovered, you know, you're actually impacting future Generations like you just mentioned transgenerational inheritance and then you know, as I got further into epigenetics, I realized there's definitely positive epigenetic changes you can make you know, and.
[00:03:19] So I started doing research on stem cells and I'm trying to basically manipulate them in positive ways in order to basically, you know, put them back into somebody but have a better more consistent benefit. Isn't epigenetics just the working arm of evolution. When we think of epigenetic, right? So evolution is preparing future generations for the environment that we inhabit today to do so isn't epigenetics just really the the arm the working arm of evolution that we see like, I mean right now people are evolving.
[00:03:56] To maintain sexual reproductive [00:04:00] Fitness through disease States. Some of it is being you through the use of pharmaceutical drugs, but but some of it is actually going to change future Generations where they will be able to sustain longer maybe in a die obese model for instance. Yeah, for sure. I mean.
[00:04:18] I think it's a more rapid response to environmental changes. Obviously your DNA can change over a long period of time over multiple Generations. Eventually you get some some DNA mutations that are positive or negative and you know, but that takes many many many generations but epigenetics is just a quicker time point so you respond more quickly by making marks on DNA.
[00:04:42] What's really interesting to me is that there's a researchers name is Michael Skinner. He studies at the genetics. He's literally growing about 5,000 mice right now. He's in Washington state and he kind of opened my eyes to the idea that epigenetic marks these marks [00:05:00] on top of your DNA again, they're inheritable, but they can also Drive mutations.
[00:05:04] They can actually impact your DNA mutations. They increase the rate of mutations if they're in certain positions and things so. That's a whole lot of facet. That's super interesting. So you can your epigenetics can change in a short term, but that can also, you know influenza Bupa. It can change a blueprint right DNA.
[00:05:25] Right? Right. Okay. So you said a second ago that there is some epigenetic things that we can do that actually will potentially make us perform better or be healthier. Can you can you can we talk a lot about the dangerous epigenetic changes as you've talked about? Environmental hormone mimicking hormone compounds both both plant and and Z know we've talked about the effects of pesticides and driving an epigenetic inheritances, but I've done a Show recently.
[00:05:57] About the potential for this craze [00:06:00] of Quito genic diet people people living in a state of very very high ketosis and that actually could epigenetically change germ cell lines and and micro RNA to cause Offspring to think that the environment is is. Fruitful and sustaining and and create a child that's more prone to obesity.
[00:06:25] What about epigenetics as it relates to making people stronger faster better performers do we can we do that too? Oh, yeah for sure. In fact, I even think your gut bacteria. They certainly have epigenetic changes that occur and I think they remember that the kind of memory write its marks on the DNA that gets passed to the next cell line.
[00:06:49] So even individual cells like gut bacteria, I think even those can change and that's the sauna actually that's where the sauna is a super beneficial [00:07:00] thing because number one it helps your body get rid of artificial estrogen through sweating. They've done skin patch testing. You know and like a nicotine patch without the nicotine on it and they've had people that aren't in the saunas and that are sitting in saunas and people sitting in saunas are sweating out BPA and phthalates and all these artificial estrogens.
[00:07:17] I read about my book. So that's obviously a mechanism for improving your epigenetics because now you don't have that negative impact, but then it also impacts your gut bacteria in a positive way and probably all the, you know, all kinds of other cells tube. Really interesting that impacts your gut bacteria and then when they divide to the Next Generation, they carry those marks, right?
[00:07:41] They carry those positive changes and then that actually can increase your testosterone because if you have crappy gut bacteria, they secrete something called LPS lippo polysaccharide and LPS has been shown to decrease testosterone. So if you've got bad gut bacteria, You decrease your your testosterone just through the [00:08:00] LPS creation through the bad gut bacteria.
[00:08:02] So you're improving your gut health actually raises testosterone. So that's one of the ways that it works positively and again, it works to protect against artificial estrogen to because you're sweating those out. This is interesting. So, you know, we've talked about the relationship between gut bacteria and hormones.
[00:08:21] In the body quite often on the show, like for instance. We talked about a few years ago about L rotary and its effect on increasing oxytocin production, but also actually reversing some of the Aging of rodents. And and so so what you're saying is interesting because I've pondered the cart and horse relationship where the chicken and egg relation between all microbes and our hormones.
[00:08:51] And you so you're saying that the the change in the microbes affects the hormones and not vice versa or can it also be a [00:09:00] bi-directional relationship. Oh, yeah, it's bi-directional as well because if you've got low testosterone and that's going to impact the cells and then the gut bacteria are sitting on those cells that are impacted their signaling mechanisms.
[00:09:11] They're speaking back and forth, you know, it's a bi-directional communication, but I. It's more so the gut bacteria influencing us than the other way around. So I think if you've got crappy gut bacteria that's going to have a bigger effect on you. And yeah, I mean
[00:09:33] well wait, okay, so I recently had blood work done and we're going to talk more about the iron overload a little bit later in the show. But right now my I'm on HRT and I'm actually. Experimenting with a new daily injectable testosterone that I have devised that I'm working with the lab and I've only taking I'm only taking three and 50 milligrams a week 50 milligrams a day.
[00:09:58] No, [00:10:00] but but yeah, but my total testosterone was 3150 and my free test was seven and 45 way off the scale wait, like I've done a couple grams of test the week and I've known when you do a thousand milligrams the test that week you get up into the 3000 but not 350 milligrams. So there's something else going on here.
[00:10:17] But here's my question to you. My gut has gotten funky on me. And now I'm starting to wonder from what you just said if my if my Androgen dominance is influencing my gut microbes to a point where it's not a good thing since I have such high testosterone such high DHT even my DHEA is Raging but that's cause I supplement with it.
[00:10:41] I wonder if that's actually effing up my gut. It could be yeah. I mean and then there's the inflammatory response to which is another way that is- epigenetic regulation or positive if you decrease inflammation, right, so that's another thing that the gut bacteria are [00:11:00] sensing. They're sensing your hormones.
[00:11:02] They're sensing your inflammatory molecules. They're called like tnf Alpha is a good example iron Lucan interferon, NF Kappa beta or nf-kappa B. There's a whole number of these inflammatory molecules that are blood that just kind of. Cruise around in our bloodstream and those are really, you know, they can be modulated by hormones.
[00:11:23] So it's kind of a step 1. You know hormones are imbalanced step to that causes insulin these inflammatory proteins being balanced step 3 that impacts your gut bacteria. It's probably more like that than a direct interaction between testosterone and gut bacteria. Can we actually prune the bad bacteria or do they become spores and just become dormant and wait until there's the stuff they like to eat back around.
[00:11:47] I've you know, I've always thought that Dino their diet influences the diversity of gut microbes. But I'm starting to think that it doesn't kill off the bad ones. The bad ones just become [00:12:00] spores and go into hibernation until the crappy food is back around again. Yeah, there's a lot of that. In fact most of the bad quote unquote bad bacteria.
[00:12:08] Most of those are called gram-negative bacteria, and that's because they have two membranes, right? So if you think of it like a cell it's got a pillowcase around it. It's got a membrane and. Yeah, Grandpa positive bacteria only have one membrane. So they're easier to kill. So if you give an antibiotic, it goes through the membrane.
[00:12:27] It kills them gram-negative bacteria. They literally have two pillowcases on their double their double-bagged and that's protects them. And yeah, they can form spores for sure. Or they can go into these dormancy States, you know have you know, you're usually the bad ones have you looked at nuts it to divert off the discussion.
[00:12:47] Have you looked at the peptide LL 3 7 it's a you have. No, no. No, you need to look at it. I just started experimenting with it. My gut is actually getting better. We're going to do a show with dr. William [00:13:00] seeds. He's the chief scientist over at the international peptide Society. I think he's focused on next week, but LL 3/7 is amazing because it will it actually kills off both gram-positive and gram-negative bacteria, and it's very effective for sibo.
[00:13:16] Interesting. Yeah. I'm not surprised. It's a cat Phyllis citizen or something like that. It's a. And antimicrobial antifungal antiviral. Yeah. Yeah if he created by your immune cells. Yeah. Yeah. Yeah, exactly. Okay, so getting back to the whole discussion about epigenetics and performance Adele Musa wrote in a blog post recently that if you want to affect your epigenetics, you have to train more frequently.
[00:13:44] I think he said training daily was more important. Why would that be. Honestly, I'm not totally sure. I mean most people honestly, they're not measuring the epigenetic changes because it's such an it's at such an emphasis infancy state. [00:14:00] So it's pretty hard to say that you know, one way or the other when whether you're positively impacting your epigenetics more or less.
[00:14:10] I think in the future we're going to have basically the 23andMe of epigenetics where you can spend the tube or something. You know and actually get back some information based on your certain epigenetic marks that you're tracking. But I mean right now we don't have that you have to do these incredibly expensive, you know sequencing.
[00:14:28] I've actually looked into doing Epi genetic sequencing for myself and they want $20,000 right now. Yeah, it'll come down. You're right one of the lab. We do it Island lab I do it all the time, but. You know, that's different because you got government grants and it's specific to some rational or rationale.
[00:14:47] You know, you've Justified it looking at a specific disease and that's why most of the most of the research is done in a negative way. They're looking at. Problems that happen and which [00:15:00] epigenetic marks are involved in those problems because there's no money in health, you know, right right so they don't care if you're a little bit healthier a little bless out that you know, but if you have a disease a straight-up disease well, then they care because there's drugs at stake and they could develop drugs that change the epigenetic marks, but I'm not as interested in that.
[00:15:18] I'm more interested in preventative stuff. I've read once that the mitochondrial DNA is more important than any other DNA. In fact mitochondrial DNA can be traced back to every woman in your lineage because we passed we get our mother's mitochondrial DNA and she got her mother's and she got her mother's and we can literally trackback mitochondrial DNA all the way back to pursue perhaps.
[00:15:43] Some origins of people to talk about or do we check mitochondrial DNA right now with 23andMe was no. No, I don't think so. Honestly. No, but there's not that many genes that are expressed in your mitochondrial DNA. It's really [00:16:00] limited. So but what is really interesting? I mean certainly there are genes there and but there's also epigenetic marks.
[00:16:08] On your mitochondria DNA, right and mitochondrial DNA Justin for your listeners. It's circular. You know, where is the DNA in our cells is linear. Yeah, but that's actually bacterial by from origin, you know, right but it still has epigenetic marks. So and so are you saying that you can look at your mitochondrial DNA and see the epigenetic drivers from previous generations?
[00:16:37] Yeah, you could track that. I mean there's literally only 30 there's only about 35 jeans on your mitochondria. But of course there's you know, there's like 16,000 DNA base pairs, right? But but anywhere and on any of those sixteen thousand base pairs, you could have mitochondria are you could have epigenetic marks that are tracked trackable for sure, but usually when [00:17:00] they tracked lineages they just track DNA mutations that are kind of.
[00:17:05] Not that important and the reason it can't be an important. Like if you have a mutation on it really important Gene that's going to kill you right is a straight-up tell you right? All right, I'll call some kind of Health dysfunction and then you're not going to survive. So you have to find DNA mutations that occur at a site.
[00:17:22] That's just kind of, you know insignificant, right? Right, then over me, you know thousands of years or hundreds even hundreds of years. You start seeing the mutations almost like almost like artifact mutations that just they happen, but they really don't affect anything. Yeah. Yeah. Those are literally evolutionarily they're used as evolution evolutionary time time clocks and other clocks, but your epigenetics you can do exactly what you're saying with epigenetics as well.
[00:17:51] But again, that would probably be more related to. Short-term changes, so it's just a time scale difference. You know, you can do the exact same thing. It would just be a shorter time. [00:18:00] So would be what is your grandparents? What did your great-grandparents eat know how healthy were they and you could modulate you can monitor that but right now I don't think anybody's practically doing that in a you know, you know it certainly not at a at a corporate sense.
[00:18:14] You know, there's no there's no company out there, too. Look out for that. So before we take the break it are there are there important discussions in the area of epigenetics and performance that that athletes should be paying attention to oh, yeah, I think so. I mean, you know, I think absolutely anything that positively impacts your epigenetics should be of interest to everybody because that's a something you can Implement immediately.
[00:18:40] And that can give you a positive, you know performance benefit. So give me an example of give me example of something. Okay, so let me think so igf-1 right right insulin-like growth factor insulin growth factor, right? You know, it's exactly like you're saying if you're in a starvation State [00:19:00] the epigenetic marks change, that's how they discovered epigenetics, you know, they discovered it with the Dutch hunger the Dutch famine when the Nazis came into.
[00:19:09] You know the Nazis came in and they cause this famine they restricted all the food lines back in the 1940s and whenever this one and it caused an instant famine, it wasn't like a slow fan. It was an instant famine and it happened over the course of the year and all of the mothers that were pregnant during that famine.
[00:19:29] You know, they of course they had children that were smaller. Which is interesting, but it's pretty pretty much expected that didn't have much nutrition. But then now the children of those children are also smaller and then find it and even though they're perfectly well nourished and people are and that's happened a couple Generations out now and people scientists start saying well wait that can't be genetic.
[00:19:48] We didn't change the DNA is the same and then they discovered epigenetics and most specific more specifically they discovered igf-1 was related to that. And I because igf-1 that you [00:20:00] know drives garlic in there are throwing lesson. Exactly. Yeah, and and that's that's dictated through epigenetic marks on what's you know on the DNA on the gene itself interesting?
[00:20:12] That's so and you know, we talked about transgenerational epigenetic inheritance and and depression with Joel green earlier this year. We love we looked at the the. Not the Russians the it happens with children. It happens with children. If you have more more BPA in the urine, for example, you have more depression in children.
[00:20:35] That's the so yeah. So what would the famine the famine that the famine not in Russia, but what's the the the other Slavic country that right now to Ukraine? Yes. I don't know the Ukraine. Yeah, and you know, they like 40% of the people. There are either on antidepressants or alcohol. And look how far back that that famine was.
[00:20:57] And you say my God. It's still affecting them all this time [00:21:00] later. So really is amazing. I want to I want to take our first commercial break. When we come back, I want to talk a little bit about a study that you are engaging. I guess you're getting people in the population. I hope my audience will participate to the carnivore diet is all the rage right now and you are looking at telomere length and part of our diet.
[00:21:21] So let's talk about that when we come back, okay? Yep. Okay, if you want to reach out to dr. J. You can reach him at his website AJ consulting company.com. He will interpret your 23andMe data and tell you interesting things about yourself that you probably won't find anywhere else. So check out the website.
[00:21:39] We'll be right back with more Super Meridian welcome.
[00:21:51] I'm pressing the wrong button here. Welcome back. You think I know how to work this board after 13 years. Welcome back to Super you radio were talking with dr. Anthony J were [00:22:00] talking about we were talking about epigenetics a moment ago. I want to talk about something new. I saw this passed around on Facebook.
[00:22:05] It's very very interesting. So, let's see about a year and a half ago. We did a show because of a study that showed that of 26 food and beverages beef was the only one that actually lengthen telomeres and you are actually asking people to join a group to Promise Too. Adhere to the new carnivore diet actually a strict version right there current Carnival diet says as long as you're eating animal flesh you're a carnivore, but you're saying eat beef exclusively and have telomeres tested before and after doing this.
[00:22:46] Is that right? That's correct. Yeah, what was so what you're looking to see if the study was? No, I'm going to go beyond that because I'm also asking people to do their blood work as [00:23:00] well and not everybody's going to do that. But the study with the red meat, they did not have people on a strict carnivore diet.
[00:23:08] So they're just eating more red meat or less red meat and they're still eating vegetables and all these other things. So it's more complicated, but I'm looking at. Strict carnivore and yeah, you know most carnivores eat birds like chickens and all this other stuff, but just to make it more precise study on sticking with just red meat.
[00:23:26] So how have you had many people jump on board yet? All right, I guess probably about 20 20 miles a day at least, you know, and when I first announced a few days ago a few other week ago, you know, I had like 50 to a hundred. So yeah, I mean at the more the better in a lot of people are going to start they're going to start their diet after New Year's, you know, which is perfectly fine because obviously during Christmas is going to be difficult for a lot of people to just do red meat only as red meat water and salt and yeah, you're absolutely right like just [00:24:00] they found it was back in 2015 and they found that eating more red meat increased telomere length.
[00:24:05] And the reason that's important is because tell longer telomeres. Are so if you lived longer life span than the one and just greater overall health. I mean Elizabeth Blackburn she won the Nobel Prize for discovering telomere is because they're so powerful. And I mean, in fact she is one of the you know, she's one of the people involved in this company tilo years, which I'm having people utilize but then of course the more important questions for me are just the unknowns, you know, we don't know much about the carnival and diet a lot of people are doing it.
[00:24:36] And there's just so many questions that I have that a lot of people have we need some data on it, you know and letting that go that ranges from blood sugar range from testosterone, right inflammation. You know which by the way telomere telomere can inform you something about so if you have longer telomeres that usually indicates you have less inflammation, right?
[00:24:59] There are [00:25:00] obviously long-term ears are going to be beneficial and and so there's a couple schools of thought on telomeres role in aging and some say. Telomeres that a longer are related to longer lifespan and now they're also saying well telomere is that don't shorten this fast. So regardless of how long they are as long as they're not shortening fast that is associated.
[00:25:24] With long life span, but you could probably show evidence for either of these because it whether somebody's let's face it. It's the natural progression for telomeres to shorten every time DNA replicates because they're kind of the toolbox of repairing missing pieces of DNA. And so if your telomeres are.
[00:25:45] Replicating frequently and I mean if your DNA is replicating frequently and your telomere is either getting longer or staying exactly the same. You're probably in really good shape. Right. Yep, exactly. It's and I mean some. Yeah, it's [00:26:00] super fascinating and it's the most important thing is you have to have a before-and-after.
[00:26:04] Right? Like people have to be eating omnivore to Joint. So it's amazing. How many people are coming to me and saying hey, I'm already carnivore. Can I join the diets? Like of course not because I don't have a before, you know, I need somebody who's an omnivore take the telomeres test and it's called tilo years and then 90 days were doing the study for 90 days, which is pretty long, you know the long time.
[00:26:26] But it kind of gets past that initial difficult stage, but then there's other reasons to you know, there's there's a lot of anecdotal evidence and frankly, you know, a lot of people are saying well, how are you at financially making money? It's like no because the team a year is company. I don't have any interest in I don't have any stock on any association with it.
[00:26:46] But I tried it try and get the the company they give me a bunch of like a hundred free test kits. They never responded to me, of course. And hopefully we can actually get the bigger study funded [00:27:00] based on some of this preliminary brighter. Right? But the good thing is that the funny thing is a lot of people expect to get paid if they join the study, but that's just because that's how a lot of people do it that the reason why people do it that way is because you can't get anybody to participate in studies unless you give them money, but in this case, there's so many people that are doing the diet that are just about to start it and because it's such a trend right now.
[00:27:25] It's not difficult like recruiting is not difficult. So I don't need to pay people because I don't need to pay people. Well, you know, you don't really, you know, be really interesting. So there's I just did a show yesterday with the form of vegan who's now caught out and wow. There are a lot of vegans that are now trying the carnivore diet because the vegan diet has let them down it didn't do what was promised to them in fact yesterday.
[00:27:52] I had Drew Morgan on and he has a YouTube channel and he's a he was a vegan for four and a half years [00:28:00] because he wanted to live a cleaner life a healthier life. He had a parent or grandparent that died of a heart attack and he kind of had a wake-up call and he thought you know, I got to stop.
[00:28:11] Eating all this red meat and and crap food and so he became a vegan and he found out that he actually got sicker being a vegan but one of the interesting things that he talked about yesterday and we had very very opening a very open discussion about bowel movement changes and you know, I'm a big believer that.
[00:28:29] If your diet is working for you your poop is actually well formed and clean. It's not mushy. If you don't have to spend hours on the bathroom trying to move abound, you know, you it goes fast and it's and it's a one wiper we called it yesterday and and so but then he opened up and said towards the end of the four and a half years.
[00:28:47] He lost his ability to maintain an erection and yeah. Oh, yeah the first day the first day he had a steak that morning he woke up with an erection. That's awesome. So surprised well and from inevitable from an [00:29:00] evolutionary perspective anything that makes your libido go away is hurting your body.
[00:29:04] And anything I improve your ability dough is helping your body and that alone should tell people if the vegan diet is working for them if you lose your period or you lose your ability to have an erection. This is not a good die for. Right a hundred percent and and one big huge distinction is they've done follow-up studies on this whole idea that meat increases telomere length and makes you healthier and they found that processed Meats do the opposite.
[00:29:29] So there's always this massively important distinction between just processed meat garbage and then actual stake like you're talking about our whole needs or you know, I go hunting on the bow hunter. So I shoot a lot of my own neck shot moose and the whole wild hogs and all kinds of stuff. Yeah.
[00:29:44] And that's on the opposite end, you know, so there is a scale and the research shows that and a lot of vegans get confused because they read are the they read scientific articles or Journal articles usually. And the studies are usually done with process me. Yes, and they're just purely Association.
[00:30:00] [00:30:00] They're just purely epidemiology. They're really pouring down studies to begin with but then they're just looking at process meets, right and that's a huge huge difference. Well, it's and see so so for Years everybody was like, oh nitrates nitrites and I say low there's you know, there's nitrates and celery celery supposed to be healthy for you, but I've come to the conclusion of about processed Meats in.
[00:30:21] Is they use very very high heat to render and cook the meat and hot we know that high heat. Cooking of meats increases nitrosamine which are cancer-causing age, but more importantly turns the meat into advanced glycation end-products bikes by scorching them and you know, the maillard effect is evidence that there is glycogen in that and it's Browning and so I really think the problem with with processed Meats lies in the high heat cooking.
[00:30:55] I'm super glad you brought up age Advanced glycation end products because I [00:31:00] think one of the reasons is the carnivore diet works. So well for many people is because karma seen which is only found in meat it actually protects against Advanced glycation end products. So the problem with the problem with Advanced glycation end products, basically for people that don't know.
[00:31:17] Advanced glycation end products are sugars that stick to everything you know, so they get stuck all over and that's one of the things you test for with hemoglobin A1C. For example, it tells you. It says hey, you've had too much sugar in your blood and now it's sticking all over your hemoglobin and that's making it sticky.
[00:31:32] It's going to cause more cloth. It's going to be a problem. Right? It's one of the ways sugar increases inflammation when it gets really high. It's also everything starts sticking to everything else. It's almost like cross-linking, you know, like right imagine you're at the morgue, you know the stuff they use at the morgue.
[00:31:47] It's called formal and or formaldehyde. And the reason that works to preserve bodies dead bodies is because it cross-links proteins. It sticks them together makes them stick together and they can't move they can't function in the [00:32:00] bacteria can't even get in there to him up. That's exactly what Advanced glycation end products do they stick things together and Karma scene is protective against that so red meat has this hidden benefit of having a protection against Advanced glycation end products, but then if you're destroying the carnosine and you're increasing the advanced glycation end.
[00:32:18] You got a big problem. I just try to balance. Okay. So since Yeah Yeah, you mentioned hba1c. I want to ask you some questions about that and your opinions. So I'm starting to not necessarily trust hba1c because I'm asking the question. How do we know that all everybody's red blood cells turn over at the same time at the same rate.
[00:32:38] I did 90 days or whatever. Yeah, but how do we know? How do we know that a a very very sick person? Is not having faster turnover their turnout turning over every 60 days and so their hba1c looks fine because that just hasn't been around long enough to actually show the real damage to it, right?
[00:32:59] Yeah. No, [00:33:00] that's a good. I mean that's a valid point. I think most people have very high age, you know, hemoglobin A1c because they're just on a chronically high sugar diet that's different. But yeah, I mean if you're really in tune with your body and what you're doing. Once you've done the past week or whatever and you get a blood test, you have to you can interpret.
[00:33:19] I think that's one of the things I do in conjunction with DNA data from 23andMe is I try and get people to send me their blood test if they have them and try and put it in that context because you have to think you know, you can't just blindly say oh this value is this so that means this and that's true of DNA that's true of everything, you know, like in medicine and most doctors today.
[00:33:40] Don't do that. Well as put special. Most of the software, you know, you send your DNA through a software program and it tells you all kinds of issues right what the software can't put into context is how old you are what sex you are. I mean, I guess I can do that but you know, they don't they don't do your age.
[00:33:58] They don't do your your training, [00:34:00] you know, how often are you help with your frequency of training, you know exercise. Yeah, they're not looking at your current diet your past diets because like an interesting example is if you're doing the yoga diet. And you're going in and out of a lot of fat loss your body actually makes more fat quicker, you know, you sort of fat like three times faster to protect against.
[00:34:22] Well, that's a prominent. Yeah from an evolutionary perspective that makes perfect sense. The body goes. Holy crap with starving next time we get food. We need to make a lot more fat to protect ourselves with this may happen again. Yeah, exactly. That's and then there's all this context you have to you have to be aware of when you look at a gene like fto for example, a lot of people look at this.
[00:34:43] It's like a fat obesity Gene fto and and you know, that's a good example of that but there's of course hundreds of other genes and you know, And like you said, you have to interpret even the LDL I think has to be really careful interpreted and most doctors aren't there just [00:35:00] telling you you need to take statins man, right?
[00:35:02] But you know what all the cholesterol information flies in the face of to well-done Studies by the University of Hawaii called the Hawaii cholesterol studies where they showed that people 70 years old and older with the highest cholesterol levels lived the longest. No one no one even. Goes well, why did this happen and what maybe we should look at this, you know this idea that cholesterol is evil is wrong.
[00:35:29] It's you know, there's more to the story. Yeah. Yeah. I did my PhD on cholesterol. So I'm on the front lines of this whole thing. I mean, they've scientific researchers were using the rabble like literally right now. We're using rabbits as a cholesterol modest or feeding them a bunch of cholesterol and they're vegetarian.
[00:35:49] Yeah, we craft. Yeah, and then and then what's really funny about that as the rabbits still don't get plaques in the arteries. So we have to inject snake venom into the rabbits to cause [00:36:00] these to drive these plaques and then you get it. It's like are you? Oh, yeah, I mean they make them in order to create the type of inflammation that will create plaque correct and it's called Russell's Viper Venom.
[00:36:11] And what's really funny is Russell's Viper Venom in humans that thins your blood but in rabbits it thickens their blood. So it's like a totally opposite physiological and then we give rabbits drugs like statins and things like that. They look at it makes them healthier because it decreases plaque formation.
[00:36:27] People are literally did this stuff. You know, I I've been involved in these kind of studies and I'm just shaking my head but it's a mess out there in the cholesterol world. And yeah, I agree. I think the most important thing is that you protect your brain, you know, you're causing huge amount of your brain is cholesterol.
[00:36:43] Yeah. And yeah protects you brain having that cholesterol. I want to take all last commercial break when we come back. I want to take the the carnivore diet a little bit further. I want to share some information with the audience about my recent blood work and I want to talk about iron overload.
[00:36:57] Okay, I'm starting to really have some [00:37:00] strong theories about iron overload. Stay tuned. We'll be right back with more superhuman radio. Wilbur.
[00:37:08] Welcome back how to drink water ticket. Dr. Anthony James website is AJ consulting company.com. He can help you interpret your DNA analysis. If you have like 23andMe, he can help you personalized diet sleep training all based on your DNA. This is really important. You know, the pharmaceutical industry is harnessing DNA to show who responds best to this drug, and that drug.
[00:37:38] And we can also use this type of an approach to lead a better life and it all starts with visiting AJ consulting company.com. So recently I shared with on Tuesday. I talked about my blood work that I just got back, you know. Dr. J. I am like the [00:38:00] mechanic who fixes everybody else's car, but my car is always broken.
[00:38:04] I tell people get blood work done every year. I tell them all the right things to do, but I don't do the right things and I'm paying the price now, so I have I have some I have some ailments. My legs have been full of pain. The muscles have been full of pain. I thought I had lactic acidosis, but I don't but my muscles just hurt and it's moved from my legs to my back into my neck and to my shoulders and to my biceps and so I went and had blood work done the other day and lo and behold.
[00:38:34] My ferritin levels are like stupid high like, oh they inching up into the 900s. And yeah, so excited about 200 probably. Oh, well, I want to talk about that. I have some theories and I'd like to bounce it off you because you're an intelligent guy and you can tell me Carl now, you're really off on this one or not, especially since this is kind of something that you're going to probably find in your research with the red meat.
[00:39:00] [00:39:00] So I find that while I don't have the HSE predisposition on the APO e allele whatever it is, I do however have some other things I want to say. It's like a th something that shows that I am a better at absorbing heme iron. Not to the point where it's a disease state but is probably an evolutionary gift right like my ancestors probably really benefited from being able to absorb iron better and store it.
[00:39:32] Okay. So with that being the case, I'm also on testosterone therapy as I talked about and my testosterone levels of very very high right now. We're trying to figure out how to lower them and keep experimenting with this new protocol that I'm working on. And so. I find myself in Iron overload. And when I look at the research on some of the symptoms of iron overload.
[00:39:54] I'm like holy crap. This is what I have. So I'm actually going to be therapeutically phlebotomist later today [00:40:00] and probably again next week and then after that maybe once every other month and my goal is to get my so here's so everybody says, oh you just want to be down below 200. And about seven or eight years ago.
[00:40:13] I started promoting this notion that everybody has a unique sweet spot for 25 hydroxy in the way. You can tell your unique sweet spot is that when your parathyroid stops producing calcitonin right then and there that that that's you can bump it bump up your your 25 hydroxy a little bit more even bump it down.
[00:40:30] But that's your personal sweet spot because you have enough 25 hydroxy that is telling your thyroid your parathyroid. Hey, we we have calcium and and. Rosacea covered already. I'm starting to think the same thing about iron and here's why. I'm starting to think that all of the things that we associated with aging muscle aches and pain stiffness, lethargy poor sleep nerve [00:41:00] degeneration all the things that we look at an old person go.
[00:41:02] Oh, you know that person's old may actually be highly contributed. By Iron overload when you look at the research on a person 40 years old and above most of them have way more iron stored in their body than they need to and so. I'm starting to think. Okay. So how do I find my iron sweet spot because I'm Mediterranean and according to dr.
[00:41:25] Dale bredesen book. I'm not supposed to be eating a lot of red meat. I've been eating two and a half pounds a day lately. Okay, and and so I'm starting to think I wonder what the indicator. For My Sweet Spot in Iron is and I'm coming up with hemoglobin. I'm thinking I want to lower my iron levels through planned for about phlebotomy until my hemoglobin starts to dip and then I want to raise him a little bit more.
[00:41:49] What do you think about that? Yeah, that's cool. I think you're on like a whole other dimension than most people. I mean most people not they're not checking their blood work near as [00:42:00] meticulously. And I mean what I do personally is I look at people's DNA of course and I'm looking at all that there's a number of hemochromatosis genes.
[00:42:11] So it's not just one gene, you know, there's a whole bunch, right? And what's your end? And of course you can have a plus plus meaning you got a bad version from your mother and a bad version from your father. And then you're going to have high iron, you know, just genetically but what I've also found in my experience is if you have a plus - maybe you have one bad version from one parent, but then you have a good version of the gene from the other parents are technically just considered a carrier for hemochromatosis that actually increases your iron level in your blood.
[00:42:39] So you usually people that are plus minus they're not above the normal range on the medical blood work, but they're right up on the top. So I tell them. Number one keep a close eye on it number to give blood exactly what you're doing. And then the other thing I mean the thing about iron the reason it's dangerous and my mind [00:43:00] is because it caught it oxidizes just like just like a rust, you know, and that's and that another important Gene.
[00:43:06] You want to check it's called transferrin. It's TF is the gene abbreviation and the reason that's an important Gene to check and relation iron is because that if you have a bad version of Trent the transferring Gene. That increases your risk for Alzheimer's because Alzheimer's is definitely related to heavy metals clearance iron clearance oxidation, you know inflammation all these kinds of things and put on low cholesterol, right?
[00:43:31] We talked about in the last segment, but you know that in my mind, that's why you want to keep such tabs on your iron in terms of keeping an eye on your hemoglobin. I think that's a great strategy. Yeah, you know so I wish I would have sent you my 23andMe before the show. How about how about we plan on having you back on and I'll send you my stuff and we'll talk about it openly on the show The sure okay, I will do that.
[00:43:54] So remember if I thought if I could bear Chamber Something would [00:44:00] also allow you to further optimize your. Your iron based on your hemoglobin, you know, but again, that's that's only in like any situations where you're really at The Cutting Edge, you know, I mean, yeah, the other thing I think about iron is that it is highly pro-inflammatory highly program and and you know, when we think about it, it's iron.
[00:44:23] It hurts like it doesn't change. To some softer molecule in your body its iron it gets inside cells and it irritates them. It causes high peroxidation. As you point out. There is some research out there that iron can actually cause problems with mitochondrial function, you know, and I'm starting to wonder.
[00:44:46] If you know there's a lot of myalgias out there and and there's a there's a lot of what's the other thing the chronic fatigue out there and and while people will go and have their lab work done in the [00:45:00] gall. Well, you know, your iron is at the top end of normal. I'm starting to wonder how many people fall into the category that you just said that you know, these people are actually ideally better suited to have lower iron levels, even though they're within the.
[00:45:15] Quote epidemiological normal range this is not good for them. And that's why I'm you think there's anything else we can triangulate with besides hemoglobin to say, okay. I have just enough iron in my body to do all the things, you know, oxygen transport dual important things, but no more than that.
[00:45:33] Yeah, it's a great question. I mean. There's potentially things you could check in your blood test and your blood but I don't think they're super standardised, you know, and be more of like a lab research kind of protocol instead of something you'd go to your doctor for right? So yeah, I think you're on the right track.
[00:45:49] I think I haven't thought about it either of course, right but I think having a balance between the minerals to like having magnesium, you know, so many people are deficient in magnesium [00:46:00] and that alters your iron uptake for if you don't have enough magnesium you got the your magnesium transport system.
[00:46:06] Is this desperate you're trying to get more minerals specifically magnesium, but what you end up doing is taking in Iron instead in place of magnesium. And then that's actually toxic. There's literally Publications on this and then that causes iron accumulation while your body continues to take up more because you're still not getting the magnesium and magnesium is known to be anti-inflammatory.
[00:46:28] And that's one of the mechanisms. Because you could ask well, how is the metal like magnesium anti-inflammatory? Well in a number of different ways, but that's one of them, you know. Yeah, it's also it also increases insulin sensitivity. Yeah, but some of the earlier other junk Pima Pima Indians so does.
[00:46:46] Thank you, sir. So does thank you heather some genes that a few people have or quite a few people actually in my genetic counseling or my Consulting. They have typed risk for type 2 diabetes and it's because [00:47:00] of zinc transporter gene. So I would say hey man, make sure you get plenty of zinc and those cases for those people because you know, most people don't need to supplement zinc.
[00:47:08] But if you're if you have potential insulin sensitivity issues because of the zinc transport, you definitely should just supplement and not worry about it, you know easy. Very very cool stuff. Okay, so I will get you I'm going to email you when you tell me what I need to get from from if I just have to give you access to my stuff at the end.
[00:47:28] Yeah. Yeah, just the raw data data file and I'll get that to you and then we'll plan another show where you can come back and tell tell me hey Carl Bell. Yeah. Yeah, you got you got to change your game brother. Yeah, this would be really cool. I so the website is AJ consulting company.com. There's some really cool stuff there other podcasts that the good doctor has done and also he can help advise you and personalize your diet your sleep and your training based on your own DNA and that's what it comes down to when we you know, we talked about individualized medicine [00:48:00] will this is individualized live styling and it's so cool and at your you'll be so far ahead of the game.
[00:48:06] So check out his website. Listen. Thanks for being on the show today. Thanks for having me. Yeah, it was fun. I will talk again soon. Yeah, I stay tuned. I'll be right back with more superhuman radio.
[00:48:20] Welcome back.
[00:48:25] Yeah, I'm really really diving deep. In fact iPhone called. I called the Del Musa today and monster Germany left him a message because I want him to help me do some of this research that I have a funny feeling about. I had a conversation a tech conversation with Ron Penna from Quest yesterday, and he told me that in America most people over 40 have what is considered very high iron levels like over the high N Dry 288 whatever it is, not a grams of leader or whatever.
[00:48:58] It is milligrams it [00:49:00] is it some picograms a leader or micrograms and leader. They. That most Americans have that today, I think about this for a second. I always looking for correlations, right and some of them are dumb and some of them aren't so if the majority of people out there, especially postmenopausal women, don't forget they catch up to men pretty quickly once they stop bleeding regularly.
[00:49:27] If the majority of people out there have what is considered high iron levels? How is this not contributing to Advanced aging how is this not contributing to muscle stiffness and soreness changes in gate and phlegm influent inflammatory issues aren't overload has been shown to. Accelerate neurodegeneration.
[00:49:50] So if you already have like some neural issues, it actually will make them happen faster. That's the linkage to [00:50:00] Alzheimer's disease. I'll bet. And if if there's literally like iron doesn't the only way you could actually quote-unquote excrete iron is if you are taking a an iron chelating drug or supplement with great regularity with great regularity.
[00:50:21] Which nobody is out there or if you do hours and hours of long-distance running or cardio those two things will allow your body to somehow reduce the Iron by excretion by paying it out pooping it out. But how many people in our die obese country today are running for hours a day. You know long distance Runners quite after anemic because of that and how many of the people in our population of taking supplements that would chelate iron or drugs without being [00:51:00] prescribed that would chelate on and get none of them nobody.
[00:51:03] So what if what if. The link between aging well. an aging horribly is managing your iron load. What if that's it now, I'm not saying it is. But there's a lot of dots that I've been connecting like, you know, Eliza never ate beef my God. She looks like she's 35 years old. Everybody's always asking to what do you do for your skin?
[00:51:27] And you know, she she gets 15 thousand steps a day just on average and she's so active and she goes to the gym and trains and I mean, I mean the woman is amazing. And I've been trying to get her to eat beef saying oh, you know you need more iron, but I could have been I probably am I am I was completely wrong.
[00:51:50] She doesn't need more iron. In fact when she was a young girl and she tried to donate blood I think in high school, they told her like she was near anemic. Oh, no, you can't donate [00:52:00] blood what if that was actually protective. What if that is the reason she has aged so well and she didn't develop any of the autoimmune disorders that plague the women in her family.
[00:52:14] Maybe instead of me teaching her to eat red meat. I need to learn from her to eat less red meat Mediterranean people as pointed out in. Dr. Dale bredesen book do much better on a fish egg and chicken poultry diet with little red meat. We may have an evolutionary gift to accumulate iron because let's face it low iron is not a good thing, but we're more prone.
[00:52:41] Having high iron in our lifestyle today. And so that evolutionary gift may be betraying me especially at my two and a half pounds of beef a day that I've been doing for the past how many months. And of course my high testosterone levels aren't helping either but that's not the point. The point isn't [00:53:00] how did my iron gets so high it's more of a discussion about is high iron.
[00:53:09] Precipitating Advanced Aging in our population and if it is if it's just as simple as donating blood every two months and finding your own personal sweet spot. Maybe you donate blood every two months and all of a sudden you find out your iron is down in the 20s and they say oh your hemoglobin is pretty low.
[00:53:27] Okay need to have your iron higher than 20. Let's bring it up to 50. And so yeah your hemoglobin bounce back to stay there. Keep your at find a way to keep your iron at 50. What if that mechanism. Of proactive taking a proactive role in managing iron would actually add years to your life and to your health would you do it?
[00:53:53] It's not that hard. So I'm actually reaching out to Adele Musa. I've already [00:54:00] left them a message. She doesn't know why I want to talk to him. But this is why I want to talk to him. I want to talk to him about doing some deep divot digging and triangulating existing research to see if there is a link to causality of certain diseases associated with Advanced aging and high iron levels.
[00:54:20] So book, we will keep you posted on that as we move forward and like I said, I'm going to give blood today and probably again next week and I'm going to get my iron levels down below a hundred see how I feel how I perform see what my hemoglobin is doing. I already have all the future test setup. I have the script for the future tests, and this is going to be exciting and you will learn from me.
[00:54:46] As we go along and I could be off base. I could be completely off-base. This could be like nah, I don't feel any better. Everything is still a mess. It may take time for me to feel different. But I promise to keep you involved in this [00:55:00] discussion as we go forward. Okay, that's all I've got for today.
[00:55:03] Check out AJ consulting company.com have dr. Anthony J. Take a look at your 23andMe and reveal how to improve your lifestyle and we'll see you next week with more Super um radio. Thank you for listening [00:56:00] today.
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