Guest: Joel Greene
I started fasting in 2007 after an interview with Dr. Mark McCarty who published the first study done on rats using the every-other-day protocol. It showed that periodic fasting elevated a variety of markers associated with improved aging and health. We've continued to discuss fasting on this show ever since. But something has changed. Like most things, we believe if a little is good a lot is better. There's a thin line between the hormetic effects of intermittent fasting and the biological perturbations of starvation. If you're someone who's tried fasting and it failed you, here's why. And to those of you just finding fasting, listen closely because you can save yourself a lot of grief.
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Show Notes:
Is Fasting Making You Fat and Insulin Resistant
[5:38] Joel’s experience with fasting and how it can backfire on you.
[10:30] Hyperinsulinemia and attenuation.
[13:30] Glucagon is the other side of the equation.
- Prolonged starvation is a stimulator of hyperglucagonemia.
[18:30] A 3 day fast can cause physiological insulin resistance.
[20:50] Increased ghrelin from fasting.
- Among sparing fat, it can also lead to gut problems.
[36:50] Epigenetic generational transference form fasting.
- Moderate fasting could confer benefits.
- Chronic fasting is likely to be detrimental.
[47:30] FGF-21 production from fasting.
[58:30] What to do when fasting backfires.
- Get your normal hunger response back.
- Insulin suppressive foods with low energy, high volume food (ie avocado with broccoli and tuna).
- Slowly walk yourself back into insulin sensitivity ( titrate asparagus, polyphenols, etc). These are foods of last resort that would have normally been used to break a fast.
- Cold exposure in the morning along with small molecules such as berberine and apigenin.
