SHR #2937: Breakthrough Telomere Study Confers Long-Term Immunity

: Natalie Kopitzke; 24 October 2022; 03 March 2023

Breakthrough Telomere Study Confers Long-Term Immunity
with Guest Prof. Alessio Lanna, PhD

The rate in which your telomeres shorten has been shown in studies to impact your lifespan. Telomeres are the tool box for DNA repair. As DNA gets damaged it gets the spare parts from telomeres that look like shoe laces on the ends of the helix strands of DNA. Once spare parts run out and your telomeres are gone, DNA starts to mutate. Science showed that an enzyme called telomerase prolonged the integrity of the length of telomeres creating a cottage industry of drugs and supplements that proposed to increase telomerase production. Well It turns out telomerase is NOT the only way to preserve and elongate telomeres. This s breakthrough science you won't hear anywhere else.

Sources: https://sentcell.life/team/

https://www.nature.com/articles/s41556-022-00991-z.epdf

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Show Notes:

Breakthrough Telomere Study Confers Long-Term Immunity

[00:05:05] Alessio explains why this study was the next logical study in the telomere discussion and what preceded this.

[00:08:34] Follow an interesting discussion on Rapamycin and intermittent fasting in terms of sirtuin production and cell senescence.

[00:11:32] Could this study be valuable for people with diseases like HIV? Alessio responds.

[00:14:16] Alessio explains what vesicles are.

[00:15:31] He goes on to describe what makes the phenomenon of telomeres rescuing T-cells, occur.

[00:16:24] There is a brief discussion about young-blood transfusions into older people followed by a conversation about blood donation and the positive impact it might have on healthspan.

[00:19:24] Alessio responds to a question of Carl on possible drug therapy in the future to stimulate this process that they are researching.

[00:20:55] The next topic of discussion is the possibility that cancer cells are immortal.

[00:27:20] Alessio expounds on the finding that AMPK may be contributing to senescence and is not all good as previously thought to be, relating to T-cells.

[00:31:00] Carl asks when the drug they are working on will be available, and Alessio responds.

[00:35:35] He goes on to explain what role the mitochondria play in T-cell memory.

[00:36:50] The discussion turns to what impact, if any, the drug could have on HIV patients.

[00:42:05] Alessio confirms that he started his own lab 2 years ago and the end goal is focused on anti-aging and longevity.

[00:42:40] Carl shares a riveting theory he has and asks Alessio to voice his opinion and this discussion conclude the interview.

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