SHR #2965: The Pep Talk; Weight Loss and Anti-Aging with GLP-1

: Webmaster; 22 December 2022; 04 January 2023

The Pep Talk; Weight Loss and Anti-Aging with GLP-1
with Guest Dr. Elizabeth Yurth, MD

WEIGHT LOSS & ANTI AGING with GLP-1, From SHR original episode early 2021 with @dryurth @boulderlongevityinstitute

GLP-1 has been a mainstay in treating Type 2 Diabetes. As the name suggests its a glucagon mimetic peptide. We are learning more and more about glucagon and how it's an important player in regulating the insulinogenic response and also tamping down the negative effects of high insulin and glucose. Glucose signaling is what makes cells senescent.

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Show Notes:

The Pep Talk; Weight Loss and Anti-Aging with GLP-1

[00:02:00] Dr Elizabeth explains what a GLP-1 agonist is.

It helps insulin sensitivity,
Regulates insulin release,
Helps cell sensitivity to insulin and,
Helps regulate the digestion of the food and our satiety.

[00:03:55] She goes on to explain the difference between postprandial changes in blood sugar and insulin with the presence of glucagon and without.

[00:05:55] GLP-1 may actually deliver on all the failed promises of Metformin without any of the negative effects. Dr Elizabeth expounds.

[00:11:00] Carl shares his view on the number one disease killing Americans.

[00:12:54] The discussion turns to:

GLP-1 having anti-inflammatory effects.
The protective effects on the brain and the nervous system.
The effects on diabetic neuropathy.

[00:17:35] Dr Elizabeth shares that the GLP-1 agonists are in phase 3 trials right now as a prevention for Alzheimer's.

[00:23:35] The difference between the long-acting and short-acting versions of GLP-1 is up for discussion next, as well as how the longer acting GLP-1 is more effective for weight loss.

[00:30:00] Dr Elizabeth elaborates on the weight loss effects as well as the dosages and some side effects.

[00:34:00] Carl shares his view on the complexity of fat loss and Dr Elizabeth joins in.

[00:35:47] The cost of long acting GLP-1 is discussed.

[00:37:20] Dr Elizabeth responds to a question on the timeframe for results to be seen.

[00:41:00] The conversation turns to a new programme called “What to Fix First”.

[00:46:45] Dr Elizabeth touches on the subject of mixing peptides.

[00:47:20] A listener asks a question on collagen peptides for vaginal use, both Carl and Dr Elizabeth responds.

[00:49:30] Sildenafil for athletic performance? No, for brown fat - Dr Elizabeth expounds. The discussion then turns to Sildenafil for weight loss and fatty liver disease.

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