Dr. Tim Blenkinsop, PhD
Most diseases that cause catastrophic loss of vision do so as a result of abnormal angiogenesis and wound healing. This may be a result of injury, aging or diabetes. New research indicates that the use of a common and inexpensive vitamin B3, nicotinamide, not only inhibits these cell transformations, but can also reverse that cell transition and slow down the development of eye diseases that may lead to vision loss or blindness. Most fascinating is that these advanced nutrient therapies may prove to effect all tissue types throughout the entire body.
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SHR # 2505 :: Nicotinamide May Treat Fibrotic Eye Diseases and Mitigate Vision Loss
Show Notes:
[ 3:20] The inspiration behind this study.
[4;42] Nicotinamide as a stem cell differentiator.
[6:00] How aging affect our eyes.
- Retinal tears can lead to a fibrotic growth.
- Epi-retinal membrane.
- This is caused by secretion of cytokines.
- PGF-beta and TNF-alpha.
[11:08] Is inflammation/ lack of resolution the problem?
[13:19] Would this therapy work for retinitis pigmentosa?
[14:38] Macular degeneration?
[18:37] B3 solution for topical application to the eyes.
[19:50] Methods of the study.
- Cultured cells from cadavers.
[26:57] NAD after chemotherapy.
[31:25] Nicotinamide upregulated Sirt-1 levels in older cell RPE models.
[37:33] What was most surprising?
- The synergistic, harmful effects of PGF-Beta and TNF- alpha in combination with each other.
[42:49] how long did it take to see differences?
[46:37] Mitochondrial biogenesis from B3.
- Not exclusive to the eye.
[55:50] Niacin’s ability to squelch an overactive immune system.
- Also helps to dilate small blood vessels in the extremities.
Show Transcript SHR # 2505 :: Nicotinamide May Treat Fibrotic Eye Diseases and Mitigate Vision Loss
