Dr. Milana Frenkel-Morgenstern, PhD - Dr. Bruce Cronstein, MD
Vitamin D is recognized as an important co-factor in several physiological processes linked with bone and calcium metabolism, and also in diverse non-skeletal outcomes, including autoimmune diseases, cardiovascular diseases, type 2 diabetes, obesity and cognitive decline, and infections. In particular, the pronounced impact of vitamin D metabolites on the immune system response, and on the development of COVID-19 infection by the novel SARS CoV-2 virus, has been previously described in a few studies worldwide. The collaborative group of scientists from the Leumit Health Services (LHS) and the Azrieli Faculty of Medicine of Bar-Ilan University aimed to determine associations of low plasma 25(OH)D with the risk of COVID-19 infection and hospitalization. Using the real-world data and Israeli cohort of 782 COVID-19 positive patients and 7,025 COVID-19 negative patients, the groups identified that low plasma vitamin D level appears to be an independent risk factor for COVID-19 infection and hospitalization. PLUS The study results revolve around the long-established idea that machines within animal and human cells turn the sugars, fats, and proteins we eat into energy used by the body's millions of cells. The molecule most used to store that energy is called adenosine triphosphate, or ATP. Along with this central role in metabolism, adenosine also helps signal other cells and serves as a building block of genetic material, and so is central to the growth of human tissue. Previous research had shown that maintaining supplies of adenosine, known to nourish the chondrocyte cells that make cartilage, also prevented osteoarthritis in similar animal models of the disease.
Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study https://pubmed.ncbi.nlm.nih.gov/32700398/
Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis https://pubmed.ncbi.nlm.nih.gov/32778777/
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Show Notes:
[6:23] The protective effects of vitamin D. How did this research come about?
- Low vitamin D is an independent risk factor for covid-19.
- <20ng/ml is a risk factor.
[10:24] Is vitamin D a viable treatment for covid-19?
- It is generally anti-viral.
- It is a precursor to LL-37 in the sense that there is a positive correlation between vitamin d and LL-37.
[18:44] Supplements vs. sun exposure.
[21:15] This study accounted for co-morbitidities.
[24:45] Viral spread in Brazil.
- Viruses spread more in the rural areas because they are farther away from the equator (sun exposure.) This flies in the face of a social interaction correlation.
[31:30] Higher vitamin d was associated w ith reduced severity of covid-19 even when the virus was contracted.
[34:05] What was the average blood level of the subjects’ vitamin D?
[38:30] Take your vitamin d with a fatty meal.
[41:12] Vitamin D tests.
- 40-80 ng/mL is the accepted range.
- If you are in this range, just worry about getting sun exposure.
[42:10] What should laypeople take from this study?
- Keep track of your vitamin D levels.
[51:51] What inspired the research on ATP and osteoarthritis?
[55:35] Caffeine’s effect on adenosine. What is its role in this model?
- This hasn’t specifically been tried yet.
[57:35] The role of adenosine in vasodilation.
[1:00:00] could creatine supplementation help to reverse this problem?
- Treating cytokines with adenosine can enhance the function of the mitochondria.
[1:11:01] what can people do to increase adenosine?
- Diet
- Creatine
- Ribose
[1:14:30] Sleep pressure from adenosine accumulation.
- Alcohol causes excessive ATP release.
[1:18:10] the 2 enzymes that increase ATP in the cell.
- Regulated by estrogen.
[1:20:00] what should laypeople take from this research?
