Coach Rob Regish - Dr. William Seeds

Listener questions are answered about training, nutrition, supplementation and more. PLUS This discussion about LL-37 should interest anyone with autoimmune or gut issues as well as chronic recurring infections. Applications, dosing and duration of use are all covered.

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[00:00:00] Welcome back to another episode of superhuman radio. It's Tuesday, which means this will be the blueprint Power Hour during the first hour. I'll be joined by my co-host coach ruggish for that. Then later in the show. We're going to be breaking ground on a much anticipated new peptide. I've been talking about it and talking about it will finally going to cover it today with dr.

[00:00:59] William [00:01:00] seeds. He is the. Chief scientific officer over at the international peptide society and we're going to talk about something called LL 3 7 if you have autoimmune disease if you have gut issues you're going to absolutely want to hear more about this particular peptide. So that's later in the show.

[00:01:18] Of course. Our title sponsor is All-American Pharmaceuticals in EFX sports right now, you get six of their top-selling products. Absolutely free. You just have to go to superhuman radio dotnet click. One of the EFX Sports banner ads enter your name address. You will pay five dollars and change for shipping but that's truly the shipping charge and you'll get a box of goodies everything from protein powder pre-workouts Advanced creatine product Advanced carbohydrate supplement.

[00:01:49] I mean, it's just it's an amazing goody bag and that's because dr. Jeff golini believes that no one should buy anything until they've tried it first. And he puts his money where his mouth is.  And [00:02:00] now without further delay calling all blueprint Army fall in line. It's time for the blueprint Power Hour with Coach Rodriguez on the Superhuman Radio Network.

[00:02:16] How you doing? I do well to week off for me. So, you know have some time to kick back and think about things you got some surgery coming up right Tuesday next week a finally foot surgery. And and you know, I got sick. Everybody knows I got sick last week and I haven't had much of an appetite one of the things about this this virus that I caught was that it just kind of just I just didn't feel like eating.

[00:02:44] And I'm down to 214 pounds. I can't believe it.  Well, like like I usually Council the great time to do body weights of right Jen's dips the whole nine yards. Yeah, I [00:03:00] I'm going to ride it. I gotta I have to start start eating now because I have surgery next week can't be foolish and like starve myself going into surgery, but I can't get over.

[00:03:13] Last time I weighed myself, I'm always between to 28 to 32. That's where I stay and last time I weighed myself was a couple weeks ago and I was 232 and I weighed myself this way. I thought just let me go so I went to the gym for the first time since I got sick. And I just I did two sets of everything push today and I was strong I felt good.

[00:03:34] I didn't want to push it. I didn't want to you know, because I'm want my body to continue continue to heal because it's still not I'm still not back to normal. I thought you know, I just want to see what I weigh.  I was shocked. I kept pushing the scaled to the left. I'm like, when is it going to end?

[00:03:49] Yeah 214 I was like 214 pounds. Are you kidding me? You know what they do. This might help you whether want to get to the extremes of body weight for me. [00:04:00] I am Body Company analysis done and I just kind of put that in my back pocket and that helps me plan. What I want to do next, you know, the benchmarks going.

[00:04:10] Wow, man. Look at this. I got down to 14. Let's see. If I drop 10 more pounds how much of that's going to be fat? How much is muscle conversely you'll be in a great position to overfeeding put out a lot of muscle if that's what you want to do. Well, I may not be able to let's see how the surgery goes.

[00:04:28] I'll be able to train upper body for sure obviously and my right leg that will have to say. So no blueprint power our next week. No, no, no different to thing. I'll be in surgery for sure. I so what's going on with the ultimate blueprint friendly reminder for the first time ever we've ever done this the ultimate blueprint is being offered at a deep discount.

[00:04:53] To the sh our audience. No stone is left unturned. I'm going to give you just three examples. Okay, there [00:05:00] are a hundred over a hundred modules in it. But these are just three of the examples module 3 you learn how to cement gains in three weeks and while most everyone loses theirs in for module 7.

[00:05:18] Details to go to programs on spoke more muscle than any other and it is coming up on its 100th year anniversary spotless track record. And then finally module 14 3 dirt cheap items you can purchase at any supermarket and they all perform 95% of the supplements on the shelves today. So. You know, and also what people think about this because this is what makes the ultimate blueprint unique you will learn how to train diet and supplement as part of a cohesive repeatable.

[00:05:55] And that's the big one repeatable system. You won't find that anywhere else [00:06:00] so collectively it's worth over. For just a few more weeks. I'm letting it go for less than a tenth of that and there are still a few slots for the early adopters to get a one-year subscription to the blueprint bulletin.

[00:06:16] Absolutely free. If that isn't the deal of the century. I don't know. What is so visit coach Rob register.com today and take everything you do to the next level. That's what the ultimate blueprint. Helps you to do and on that we have a question from Rick Brown. He said I've heard you speak recently about a woman that you train with that you actually train.

[00:06:43] She's a client of yours. She has Ankylosing Spondylitis and the video you showed up for performing wall walks was impressive enough, but with 50 extra pounds is crazy. I too have this condition. I'd like to know what you've learned in two years of training [00:07:00] someone with this disease. Yeah, well, it's really interesting for those unfamiliar Ankylosing Spondylitis is a chronic degenerative arthritic condition that attacks different joints in the body, but in particular the SI joint and so from there.

[00:07:20] Yes progressively marches up your spine. It fuses the vertebrae together. Now as you can imagine that eventually leads to life of a chair and the News doesn't get much better. Yes can also attack the rib cage ultimately making it very difficult to breathe. Some looks like somebody's got you in a bear hug, and they're squeezing real tight fact.

[00:07:43] My client has a friend in, Texas. Her AF attacked her jaw and ankles. The result is that she's got to eat through a straw and she can't walk. So this is scary stuff right all the more so when I learned [00:08:00] I have the gene for it now that doesn't necessarily mean they're going to get it but it will see how it will give you pause.

[00:08:07] That's for sure. Anyway bike the client was diagnosed a little more than two years ago in her very early 30s. At the time the doctor older look there's not much. You can do just kind of go home and see how the fusing progresses, you know, she is taking medication to control the inflammation and pain.

[00:08:29] She's in chronic pain all the time things like Humira Gabapentin, which. As we know they come with their own risk factors, but nevertheless she reports she does get some relief from them. It's you know this whole business about go home and wait and we'll see how the fusing Progressive that really set her off and caused her to look into other avenues.

[00:08:58] Right? So she came to me [00:09:00] a few months after getting that advice from the doctors now important to point out. I did that and I don't promise people Miracles but I did share with her My long-standing Philosophy. There is always something you can do. Right? So we launched a new program with hip belt squats bridging a few basic push and pull moves along with strengthening the Arabs twice a week much to her amazement.

[00:09:30] She was able and still is to make regular progress of every session. That's an earth-shattering just the same one extra rep or five more pounds advice that I usually espouse in the year. She can hit back squat 250 pounds for 20 at the year-and-a-half bark. She did 300 for 20 and you know upon trying a single Bridge from the floor.

[00:09:59] She was [00:10:00] unable to raise her back. Okay off the floor even by an inch today. She does those warlocks of 50 pounds of combined combined weight vest and chains a feat that she can take to any gym in the world and very few people could duplicate it, especially when you consider it as a percentage of her body weight, so.

[00:10:26] So what have we learned in two years? I can tell you that regular physical exercise resistance training for a s patients is like shaking and ice cube tray. It mitigates the fusing whatever fusing that's going on and it allows people to function much more effectively. With respect to movements the most helpful.

[00:10:51] She reports that reverse Hyper's well walk set both squats and pullovers are crucial to her health and well-being [00:11:00] more importantly, you know, she feels great about herself now because everyone in her orbit was telling her she was disabled, you know, even qualified for a disability sticker on her car.

[00:11:14] Due to the pain that she's usually but I never saw it. That way. I said you're not disabled on my watch and I expect and I get a hundred percent on over every time no different than anyone else. So the message is this.  You can. Improve the quality of your life dramatically in my opinion. If you follow similar tivitz, there may not be a cure for a s as of yet, but there's also a lot more that you can do than what most doctors lead you to believe.

[00:11:53] And I said about plenty of other people with NES and they report a lot of similar things. So. [00:12:00] Don't don't feel bad man. There's always something that you can do. I know because think about think about the the well go home and let's just watch how the fusing occurs. Well, how can they fuse if you keep them moving your the in order for them to fuse they have to like be left in the same place long enough to where they can start growing bone across from bone, you know, I mean, it's like well if you keep moving that doesn't happen.

[00:12:23] Yeah in the ice cube tray was her analogy. Yeah, and it's very appropriate. Charles Gassaway says, where do you stand on this crate Tom situation? I mean the recent news about heavy metals. Haven't we found heavy metals last year also In Crowd mm. They'll last year. I think it was salmonella. Oh, yeah, you're right.

[00:12:45] But but but see look the deal. Is this the whole FDA cray Thompson's situation is simply a continuation. Of the government's war on anything that competes with its precious opioids and prescription [00:13:00] drugs, you know the opioids right the stuff that's killing people at a record Pace the FDA in DEA are working in concert with the usual government puppets IE the Rand Corporation to try and establish how toxic.

[00:13:19] Addictive and evil Kratom is and the the opening Salvo was straight out of the fda's Playbook. Great Tom is dangerous. It's addictive it's ruining people's lives and it'll kill you except for one little detail. None of that is true. It started with crate on quote unquote overdoses and and soon thereafter.

[00:13:46] Yes that they were trying to attribute to pray time except when the American Kratom Association dug into those case histories the FDA DEA left that one little detail [00:14:00] people who died from Cortland Court Kratom overdoses.  Also ingested large amounts of either prescription or illegal street drugs in several instances opioid prescription drugs.

[00:14:16] Sherwin clay time and cocaine. All right, that was one case history that I read and out of all of those. Yeah, but it was the Kratom that killed exactly, you know, and once they got exposed by that on that by the American Kratom Association the FDA start to pursue another angle. So the next Bogeyman.

[00:14:39] With salmonella in people's great time except that to was exposed when it was found out some of these people who have taken Krakow and also Wheaton undercooked chicken or eggs to say nothing of the fact salmonella occasionally pops up in the food supply or I was the latest [00:15:00] one let us or Yale. Yeah, right, but nobody's building Levis who never be right.

[00:15:05] Yeah, so. It remains unclear to me if any crates on Brands really contain. Salmonella. I wouldn't be surprised if the whole thing was made up and had no basis in reality the new angle. They're trying is that crate on contains excessive amounts of heavy metals now, do you see the pattern there?

[00:15:26] American Kratom Association scientists have some fairly refuted. The FDA the dea's arguments that the chemical constituents and create somber addictive and toxic they're going after peripherally Associated things like salmonella and heavy metals. Look if you value your supplement freedoms.  Beyond crater please support.

[00:15:56] The American playtime Association of [00:16:00] American Kratom dot-org even a small amount helps them fight this FDA and DEA. Tyranny shining a light on their dirty tactics had we had an organization like AKA we may still have pro hormones. So please, you know, please do your part. To fight the government's goal of ending your right to use safe natural products.

[00:16:28] It's time to send a message to them in their big Pharma Masters. It's really a shame with the trying to do but it didn't Chris Bell come out with a cranham documentary has that come out yet. I have heard that I have not seen it. I mean, let's use common sense here folks, you know, nobody's dying from great job.

[00:16:51] Yeah. I know nobody's addicted to create I'm you know, if they are that's about the least offending subject. [00:17:00] That's the last thing the people more people are addicted to coffee just for the record. I have a 13 year old son. Great time would be the last of most of those players that I mentioned last thing.

[00:17:11] You know that I would be worried about right. Let's take a quick commercial break when we come back. We have a question from Hunter Stark. You're listening to the blueprint Power Hour. Stay tuned.  Welcome back.  So the next question comes oh, by the way, if you listen to us on your iPhone, can you go to iTunes and please rate the show?

[00:17:37] Some somebody who I'm not going to mention their name went up there and put some slanderous stuff about the show and it's and and the funny thing is that it's an orchestrated. It was orchestrated by one person because they call these happened at the same time. But the big complaint is that the show has too many commercials.

[00:18:00] [00:18:00] It's one big commercial with the small smattering of information, which is you know, it's just not the truth. And people don't like the commercials day for five dollars a month. They can get a commercial free version at patreon. Yeah just can't make people happy. But anyway, yeah now it's you know, it's a personal attack it with those of you who get there.

[00:18:19] We'll see who it is. He's known to be a douchebag and he just like comes on and says, you know horrible things about me and the show and Eliza and some of the others own show people know him. He writes books. Yeah, he didn't hide who he was. He puts his name on it. Well anyway, but yeah, I would love to get that buried down down down.

[00:18:44] So if more people could go out there to iTunes and you know rate the show and make a comment. That would be great hunter stock says like you I have a young son. Can you tell me how your training yours and give me a general guideline [00:19:00] as how to train a 12 to 13 year. I really want to go to do right by my son.

[00:19:05] You know, I get a lot of questions as to what the right age is, you know to start kids training. And judging by these questions. There's also a lot of Dogma still out there about you. Don't growth growth plates closing prematurely, you know kids are only going to get hurt. I'll tell you what I did and why so hopefully others in the audience with young children can benefit I started my son training at age 12 why that age because I think I've n he had a level of emotional maturity.

[00:19:41] To handle, you know the basics and one of those Basics is going to the gym right two or three times a week, which is an important anchor and their development. It's important because there can be no progress really in anything without consistency. [00:20:00] And the Very Act of going somewhere to train is a lifestyle habit that will stick with them.

[00:20:05] Hopefully for a lifetime. I chose bodyweight stuff at first for several different reasons first it strengthens that just the muscles but all of the underlying tissues tendons the ligaments of Bursa of the fascia and that's important because to do otherwise is to try and shoot a cannon from a canoe as dr.

[00:20:30] Squad used to say that things are going to happen second by using just body. You have a built-in mode of progressive why because every month that ticks by for one of these young kids. They're getting taller and heavier. Right? So that in and of itself is a method of progressive resistance, even if they keep the weights and Reps, you know the same and all exercises.

[00:21:00] [00:21:00] They're going to be getting progressively stronger now, I. I deliberately kept the first few months sessions to no more than 10 minutes, you know two exercises per workout to work sets per exercise his response to the first workout, which only lasted a few minutes was that's it. The point that you're trying to make is that these workouts are not something to drink.

[00:21:28] You know, they're manageable in the child can actually look forward to them. Now the first few workouts, of course, he was understandably very weak. Right we all start somewhere but that soon changed and in some cases dramatically a year-and-a-half labor later. He's able to perform one-legged squats.

[00:21:51] I'm not kidding with 60 pounds. 20 pounds of weight for us to the holes of 40-pound dumbbell [00:22:00] his abs are likewise very strong. His upper body is lagging but you know, I tried to explain to him that that's okay because everyone progresses at their own pace. So in summary Hunter I would tell you that just two workouts a week using maybe in the upper upper body lower body splitting.

[00:22:24] Work wonders for kids at this age. It's a minimal time commitment and they walk away in some cases with a huge sense of accomplishment someday. They will look back and thank you for starting them. So young and showing him the ropes. So think about how young they were teaching kids gymnastics. Well, forget all that think about how young kids worked side by side with their family farming 500 years ago.

[00:22:53] You'd everybody said. Oh, yeah, let's not have Harry work with us yet his growth plates may [00:23:00] close. No, it's like as soon as the kid was able to carry a bale of hay day made him carry. Hey, right and not just one back and forth. You know, it's like this. The thing that I find absurd is when we make these statements, you know, like oh, you know children children should not be doing this kind of work.

[00:23:22] It's like who told people 400,000 years ago that children shouldn't be working alongside with their parents, right?  I mean and tell me and tell me how that destroyed the children because. They had children and they had children and clearly we're here today because they had children and so it's like it's just an absurdity.

[00:23:44] It really is we fabricate this nonsense a lot and you know what the internet has made it a thousand times harder to decipher or at least stay out of its way really has of course, Jeffrey Adkins says if I were to take [00:24:00] just two things with the aim of getting larger and stronger as fast as possible.

[00:24:07] What would those be the only qualify is they have to be legal mannequin. I was this a trend and Deebo.

[00:24:17] Yeah, okay, but listen if they have to be legal, I honestly would tell you simple gym and progenitor X here's why it doesn't matter how good of a program you're on. Okay. The rate limiting factor will always be recovery time. So let's say using Charles daily zvt, which is an excellent program and highly recommended under normal circumstances.

[00:24:48] It may take you ten weeks to complete. Let's say 30 work. You better run that same program with simpleton though. If it's a good bet you could pull it off in six. So in [00:25:00] other words, you could reap the gains from eight of those EDT Cycles a year with some of the gym versus let's say five without it doesn't take a rocket scientist to see how fast.

[00:25:12] The muscle starts piling up right when you're recovering that quickly the other rate limiting factor in most people size games is eating big. You just aren't going to get anywhere Roque eating at maintenance or. Even if you're a little bit about when you're an octave or it's all about the Ed but there's a problem with overfeeding the longer it goes the more active the enzymes are that store fat projected Rex excels in so far as increasing your appetite, but also making sure the gains are in your chest arms back and legs not.

[00:25:53] Your waist and that's due largely to the am a cyclist pyrethrin that is used. Although other [00:26:00] ingredients that are in there like our ala electrode should of those also contribute.  It's also true that two of the most Rock Solid ingredients you could use.  Are creatine and beta-alanine? And the fifth Jennifer Jennings rexxar hell of a lot more than that, but look at in the context of creatine symptoms of has a I'm sorry progenitor, excessive and a very bioavailable form of it and beta alanine is inherent in censorship and let's not forget, you know in the past few weeks I'm speaking about this.

[00:26:45] Levine has the potential to rob you of protein synthesis because it combines with the essential amino acid histidine and therefore, you know subverts [00:27:00] your ultimate protein synthesis, you know, you you'll end up with a lot of carnosine in your muscles, but I'm not so sure the muscles are going to be as big.

[00:27:10] If they were allowed to use of History, so listen, I know I'm biased but the one-two punch you get from those two products has to be experienced to be believed and you know, what don't take my word for it. Go on the board. Anybody who's taken both what training of them feels like? Okay, it's not like yeah, I think it's working and know it hits you like a hammer over your head.

[00:27:41] There's simply note. And again, these aren't my words. No comparison to anything else that's legal head on over to. Either bodybuilding supplements.com or Predator nutrition.com and read what people have to say [00:28:00] especially a predator. They are a very tough crowd but they consistently both products consistently get five star reviews and have for years.

[00:28:12] So that's just something to think about when you're evaluating those two products or any two. What people said about it over years and years and years and there's a reason they're still around years later people keep buying them.  Jacob McDougall says I heard you speak about your 30th Highschool reunions last week cool story and gave me some real hope you mentioned you've battled depression what has worked for you?

[00:28:41] Yeah, you know what? This is a personal topic, but it Bears repeating because I know more than a few of you are hurting. What follows is my experience with the trials and tribulations that I've been through along with some conjecture about what might work for people if it [00:29:00] helps even one of you it'll be worth it.

[00:29:02] So from a very young age. I can remember having episodes of depression. I took things hard really hard like it was the end of the world hard. It didn't matter if I was giving let's see beaten in the baseball game or rejected by girl or you know made to feel like a failure by my dad. All of it sent me into a depression I would dwell on those failures in some cases.

[00:29:35] I would beat myself up for years here and there I would feel a little bit better, but I honestly felt you know, that's how life was that was normal. It was how everyone lived or so I thought then something amazing happened. I discovered stimulant it in particular ephedrine and caffeine [00:30:00] and I can distinctly recall from my very first dose feeling borderline happy and thinking wow.

[00:30:08] This must be what it's like to feel normal.  and so looking back obviously, I was self-medicating the stimulants helped but. Not as much as what I use them for.  And I'm talking about exercise and I will tell you now after trying every antidepressant in the book. Nothing lifts depression like exercise nothing.

[00:30:38] Later, when my life took a god-awful term the doctors were prescribing all these antidepressants. If I'm usually not one Euro for prescription medication, but when you're hurting that bad you're desperate so they give me you know one after the other after the other one of those [00:31:00] of never forget it affects or made me suicidal.

[00:31:05] Okay, and I just got done telling you I've had issues with depression, but never even in my darkest moments was I suicidal? That poison effects or though did it and it wasn't the only one that made me feel worse, you know the real breakthrough in terms of my mood.  Was testosterone for HRT now at that point I felt I really felt like I was hitting on all cylinders by mood is night and day.

[00:31:40] Well, once I got my Tesla was to normal the all of a sudden the glass is half full now do I still use stimulants? Absolutely, but I exercise almost daily. If I don't exercise. I just don't feel right. I have if things get really bad I [00:32:00] have fell abou and crate. I'm on here right if I really need them.

[00:32:06] But this is another big one and I really want people to listen to this and think about it.  I learned to let go of the past and the forgive myself.  I learned to forgive others and I learned how to ask for forgiveness forgiveness is a big part of getting better.  Almost as big as exercise. I would tell you.

[00:32:33] I wish I could get everyone suffered from depression. Be cure. I really do the truth is it took many years a lot of trial and error and the act of forgiving myself for past mistakes that finally healed me surrounding yourself with positive people also helps as does staying the hell away from alcohol.

[00:33:00] [00:33:00] I lost because of that. With suicide in part because the alcohol made his depression worse.  I got on here last week and I talked about it my offer still stands. If you're depressed of hurting you want to talk to someone that gets it and really understands. My cell phone is eight six. Oh seven five three zero three seven three.

[00:33:31] Call if you need to talk to someone and I appreciate your question.  Ian, we're going to take a quick commercial break when we come back. We have a question from Hank Kozlowski and you're listening to the blueprint power hour later in the show. We're going to talk about ll3 seven new peptide. You're going to want to know more about stay tuned.

[00:33:52] We'll be right back. Welcome back. Hank Kozlowski says, I finally got around to trying that [00:34:00] C4 stuff. You recommended good kick in the pants, but I couldn't get to sleep that night. I train around 5 p.m. What else? Can I take I see they have an extreme version. Yeah, you don't want to take that and train at 5 p.m.

[00:34:15] Yeah, but there has to be some miscommunication here because I never recommend C4. In fact, I counsel people to stay the hell away from it. Hi, you know what? I got to tell you the truth. I'm reading this and I'm thinking when did Rob mentioned C4? I mean, I know what this stuff is and its really I mean that and that dr.

[00:34:35] Jekyll and mr. Hyde stuff. They're just really hyped up stims. That's all it's just full of stims.  Well, I actually. Little further in the sea floor when mentioned the extreme version the regular version sells for around 35 bucks. Okay, if you want to get extreme though, you're going to have to pay between 50 and [00:35:00] 60.

[00:35:00] Let me tell you what you get for your money.  It costs around $6 for everything that's in C4 including the bottle of the shiny label that comes with it. The chief ingredient really is the only one that's providing. Most of the stimulation is caffeine. Now, it's dressed up under different names. But anywhere between three and four hundred milligrams of caffeine is giving you quote unquote energy that you feel.

[00:35:34] You might as well purchase Walmart's jet alert caffeine tablets generic caffeine, which gives you 90 200 milligram tabs.  For three dollars and change so see for them is some of the most expensive caffeine you will ever ingest if they are laughing all the way to the bank. Unless of [00:36:00] course you shall out over 50 for the extreme version.

[00:36:04] They're probably laughing harder at you for that one because for that additional 15 or 20 bucks you're. You'll have me it is usually disguised as rawal Thea something or other sometimes reward thee a serpentina. I've seen other weird names, but at the end of the day it is just Yohimbe. For those of you who have used your hand be consider yourself fortunate in my opinion.

[00:36:35] It makes your skin crawl you get a very rapid heartbeat you get shaky sweaty and paranoid. It is the worst ingredient on the market in my opinion, especially for a pre-workout.  I would also tell you this the excessive amounts of caffeine and you'll him be in the product. All conspire [00:37:00] to leave you smaller weaker and lighter in the wallet for doing business with them users.

[00:37:07] And I want you to look around. I really want you to talk to people and look around because I know a lot of the gym sell this junk users of C-4 are clearly swimming in cortisol. They are overtrained and over the long term. Stringy and week I've seen this over and over and over in the to Jim's I belong to do some people like feeling you know that over stimulated maybe but you know what Beth does the same thing even better and in the end C4 gets you pretty much of the same place, maybe not arrested, but you're going to wind up looking like a method on it.

[00:37:53] It's terrible. I mean it really is I have seen examples call where even [00:38:00] chronic overfeeding, you know, anywhere between 9 and 10 hours of sleep a night and a good routine could not overcome the cortisol that is released when you down this stuff and I know exactly what you're saying about. Jekyll and Hyde or whatever then I've used some of these things and I got to tell you something man.

[00:38:24] They make you feel horrible after you come down off of him you feel so washed out. You think he like I've used that Jekyll, dr. Jekyll or whatever. It's called or mr. Hyde. It's a shot. Yep. You get it at Vitamin Shoppe. I remember one time. I was like, I need a little energy and I'll try this stuff.

[00:38:43] And I bought two of them. I think I bought two of them at this the counter there, right? And I took the one and I felt it right away. I was like damn. Yep. And then then when I came off like about eight nine hours later. I felt sick. I felt washed out I felt. Weird and I thought to myself [00:39:00] I wonder if there's something in that that's not on the label right?

[00:39:04] Because I don't I mean I've taken a thousand milligrams of caffeine anhydrous and I didn't feel sick later on that evening like like I was crashing from it right that we talked on the show about ephedrine we talked about cray time. We've talked about all these things that they either banned or they're trying to get them ironically.

[00:39:27] I consider without a doubt the most dangerous ingredient on the open market is bulk. Yohimbe where it's just a free powder. If you will you'll him be will crack you out in the dosage anywhere between one and five milligrams. Think about that one and five milligrams. I once had a friend this name is John.

[00:39:56] He screwed up his boat kill him be dosing.  [00:40:00] And I got the following phone call. Hi Rob. It's inch John sister. He's in the hospital and can't breathe on his own. Do you know what he took? Trust me when I tell you you do not want to take that phone call, you know, ultimately he wound up being okay.

[00:40:23] But that's what too much you'll then be can do for you. It is not a pleasant experience. No, that is a lie. I mean your him he's been tied to people going into cardiac arrest and who else exactly so and and most people. Like if I take you him being I don't feel good. I don't feel like oh man. I want to I'm gonna work out so hard.

[00:40:44] No I'm sweating. I got like this cold hot sweat thing going on. I'm like, wow, why do I feel this way? What's wrong with me? No. No, I'm not clear headed to go out. No, I want to go crush the weights down. No, it's more like, oh man. Am I going into cardiac arrest? What is this? What's why do I feel this [00:41:00] way?

[00:41:00] Yeah. Yeah exactly you hit the nail on the head you feel cold and clammy but at the same time your sweater, yeah. Yeah, I mean think about this.  Just replace your him be with the flu and that they're basically yeah, exactly. Yeah, that's a great Point. Hey, everybody go out and get the flu and then crushed awaits the next day, you know, it's so stupid and and yohimbine has been around forever.

[00:41:30] I mean back in the day when 20 years ago. Yohimbine before made it into the workout. Segment it was an aphrodisiac. It was a sexual stimulant. It was It was supposed to help guys get erections. Who cares if you have this really great Direction and you're dripping sweat profusely and you don't feel good all of a sudden right?

[00:41:53] And when you say you don't feel good. I mean that is the understatement of the year it is if you just feel horrible you really do. [00:42:00] I don't know how people. Why don't we go ahead and roll right into the blueprint tip of the day? Okay, cool tip of the day is false since it since I run way too many commercials.

[00:42:12] I'm going to cut a commercial break out the tip of the day's thoughts on balancing work and training. So no matter who you are. There's a real good chance. You're going to have to balance work. Other outside activities with your training and that brings up the question of what time of day it's best to train but to be totally honest, I think there's you know more individual variables in that that even recovery time.

[00:42:43] So with respect to time of day the train. I've seen study saying people are strongest in the afternoon, but I also know people that are shot after 2 p.m. And they gain better by training in the morning again time [00:43:00] management.  What became clear to me shortly after you know my career? Quote unquote starting to get rolling was that I had a lot to do man for whatever day.

[00:43:11] I woke up. So ultimately I put a gym in my basement and I trained early in the morning and you know shortly after waking up that accomplished a couple of important things one after the workout was done it was done right? You don't have to worry about. How bad did they beat you down? You know what you feel like when you get out of work there were two it eliminated any commute eliminates time to get changed and unchanged waiting for equipment just a win-win all around in the area of time management and then three.

[00:43:46] It brings the idiot Factor down to 0 right and it eliminated a lot of distractions. Now that everyone is wired to train by themselves. You have to be a real [00:44:00] quote unquote stealth self-starter and more importantly the someone that's capable of pushing yourself a hundred percent without any external influence.

[00:44:10] And from what I've seen that's pretty rare. No exercising early also seem to put me in a better mood of a much better move when I arrived for work. Unfortunately for me, that usually did last one right the more the more hours. I work the more money. I made the more miserable I got I can only imagine how distraught I would have been had I arrived home from work.

[00:44:40] Completely gassed and then mr. Workout. So training early and training solo was fine for me, but that's not the end of the story these days 20 years later. I belong to two different gyms. [00:45:00] If I train in them as I no longer have the space necessary for a home gym. I mean, well, you know, I do have some equipment but it's more or less for Nicholas.

[00:45:10] You know, there's there's a small area for bodyweight stuff a pair of power blocks and an adjustable bench, but I also bring him to the gym with me to to give him exposure. To both environments and it's very interesting watching people training in both of those environments. You can learn a lot about yourself.

[00:45:34] I also train now now if the mid-to-late afternoon, I find it more conducive to my schedule and I'm a lot more sociable in my 40s now than I ever was when I was young. You know the truth is I'm an introvert turned extrovert I guess.  And I also definitely feel there's [00:46:00] something to be said for competition in the gym, you know, I thoroughly enjoy trying to outdo these 20 year olds, but I also enjoy seeing friends and exchanging ideas.

[00:46:12] And that's one thing you'll miss the home gym set. What you can learn from others, you don't always have to talk to them right? You can learn by watching.  Finally, I've added the the whole Jiu-Jitsu wrinkle from the past two years taking classes.  Two or three days a week. I find. However, I that I can't do both right you can't do both on the same day reason specially if I'm a really hard workout.

[00:46:39] It's just too much, you know and giving less than a hundred percent. To both seems like a compromise.  That being said they still both result in the immense satisfaction, you know once they're done so in closing, [00:47:00] I would just Council you in the area of balancing work and training. I would counsel you to try both training by yourself trading on the commercial gym.

[00:47:14] Trailing early in the morning training later in the afternoon and maybe adding a few workouts a week at home during doing bodyweight stuff in a few workouts a week in the commercial gym. It doesn't have to be either over if you could Leverage The Best of both of those worlds.  You will be a lot better off for the experience in my opinion.

[00:47:41] I know you're someone who likes to go to the gym, right girl. I like to go first thing in the morning. Yeah. Yeah. I like to get it out because I feel that if I go first thing in the morning then I do everything else the rest of the day that I'm supposed to do. I'll eat I'll lie properly. Oh, you know it all falls in place.

[00:47:59] Once I get that [00:48:00] training session on the my belt. Yeah, I agree. Well, that's.  it's been a while since I've done that but. But I was listening to you. I was thinking I wonder what would happen if I started training in the afternoon, right? Right. I can still remember the weather but I have a home gym.

[00:48:17] I can still remember. Sometimes you calling me early in the day. It'd be like what are you doing? I'm training. It was like 6 a.m. Or something like that, right? But listen, you should try both learn from the experiences. You will be better for both. You think there's any value to switching it up?

[00:48:40] You know just just going like you've if you've trained it or first thing in the morning for years. Yep, just switching it up and say okay. I'm not going to train first thing in the morning for the next couple weeks. I'm going to try going in the evening. How long do you think it takes before you kind of are your body goes?

[00:48:56] Okay, I can do this for a while three weeks.  [00:49:00] You know if you give your not a morning trainer now. Did you switch the morning training or vice versa? I think after three weeks if you can make it through those three weeks. It'll be much easier for you. Don't Johnny Gray writes the show a lot. Yeah.

[00:49:16] See forever and a day because he was a cop is a cop trains in the morning, but he wrote me the other day and he said what do you think about if I switch the training in the afternoon? I said sure but why he says I hate feeling rushed. I don't feel like I'm doing Justice. Yes my workouts if you got that situation going on.

[00:49:37] Absolutely, you know do it. You know, I feel rushed no matter what if I trained in the afternoon, I would feel rushed. I've always feel like I'm so when I'm training, I always feel like I'm stealing valuable important time that I should be doing should be doing other things. I've felt that way. I felt that way about my training.

[00:49:57] The only time I didn't feel that way about training is when I was living by [00:50:00] myself, right? When you live by yourself, it's like nobody's expecting you to do anything and but you know when you're part of a relationship, it's like you feel like you're you know, you're oh, oh I'm taking too much time training.

[00:50:12] There's other things I should be doing.  Yeah, you're you're one of the busiest guys I've ever known though, and I can understand why you've got a lot of balls in the air. Yeah, so I want to stop that to my I was talking to my friend Tony vinetti today at the gym. And we were talking about you know, he's going to retire from Radio someday.

[00:50:34] He said when I retire he goes, I'm going to not only come to the gym in the morning you guys but I'm going to come back later in the afternoon. Yeah, he goes out. He says everybody wants to go golfing right? He does not want to go to the gym.  Especially you you know, I mean you got surgery coming up slow down to smell the roses man.

[00:50:53] Look what you've been. What's the been 13 14 13 years 13 years 13 [00:51:00] years, but apparently I don't know what I'm doing yet because I run way too many commercials. Yeah, right. That's why you're here 13 years later. Some of these people kill me now. Like if you go to if those of you listening to the show go to iTunes and comment on and rate the show.

[00:51:15] I really would appreciate that. I generally I've never I don't think I've asked anybody to do this, but. And and look specifically for the people who say it's a small smattering of information and nothing but commercials like I get it. I definitely have more commercials than some other podcasts, but I didn't start out as a podcast.

[00:51:35] I started out as a terrestrial radio show on AM radio. A whole five bucks for no commercial. Well, I yeah, and if you don't like the commercials is five dollars to get your commercial free version of it over to patreon. So there's that but I mean it's like.  whose standards are they comparing me to?

[00:51:54] Oh, it's this nothing but commercials if you like if you just want to listen to commercials, this is the show for [00:52:00] you. Somebody said.

[00:52:04] well, hey. I think you said it once that's what you've got theaters, you know, you've arrived I think really the funniest thing is.  I look back now and.  Think about all the podcasts that popped up that will like world-beater podcasts about health and fitness and then they just all gone by the wayside.

[00:52:32] Yeah. That's a really good point. I mean I can name name in Sean croxton was great. I mean Sean Crocs and he was setting the world on fire, you know just eat real food and you know, he had a huge following and then one day he said in a post that he was going to cancel his podcast because there's really nothing new to talk about in the health and fitness area any.

[00:53:00] [00:53:00] Right, and I said to myself a you're kidding me, right? Like there's nothing new and then another guy was a mere Rosa Cami rosic had a podcast for a while and he did some sort of kettlebell Championship thing in Canada, and I had him on the show because it was very impressive. Do you remember him?

[00:53:20] Yeah, I do have with you see up to London. Well, then so then he went to the then he switched from that to becoming like a entrepreneur motivational guy. So he got away from fitness and health and he started doing entrepreneur motivation. Then he became blockchain cryptocurrency. He started advising people how to invest in cryptocurrency and make big money in that and now with the crash of.

[00:53:47] Bitcoin I don't know what he's doing right now, but I mean, it's like I think about these people because at that time they were like literally like building a huge audience and getting a great following and then [00:54:00] they decided that the, you know health and fitness really wasn't what they wanted to do.

[00:54:02] What they really want to do is just get rich. So what can I do to get rich because I'm not going to get rich talking about health and fitness and then they just left this the category. I'll tell you who else to lab. Well, no, Eric fiorello. Eric fiorello we yes, what's the latest there? I don't know but I'm just saying I mean, he's another guy I had him on the show and I tried to give him a little heave-ho and what did he do?

[00:54:28] He badmouth me on the boards and all its of and and he had his own podcast for a while and then. I don't know. What is he still doing that podcast? I don't know. I don't know if he is. I heard that was a really sad thing because you did you try to give this guy stabs stabs me in the back and uses a fake name and put stuff up on the Superman radio Forum over anabolic Minds.

[00:54:52] It was so transparent. It was funny. The best part is that's out there for her for her for [00:55:00] eternity. Yeah. Yeah exactly. I got nothing that I mean, I'm not embarrassed about it, but somebody has to be embarrassed about that. Anyway, that's it for today boys and girls for the blueprint Power Hour.

[00:55:10] We're going to leave Rob register just a. And when we come back going to be joined by dr. William seeds. Thanks a lot. Thank you. And of course go to Coach Rob register.com to learn more stay tuned. We'll be right back.  Welcome back, you know, we've talked about it before peptides.  Quite potentially present some of the greatest most exciting breakthroughs in modern medicine today and trying to discover.

[00:55:40] New and useful peptides for the audiences something that I love doing and I have a go-to guy.  And that is dr. William seeds. How you doing? Dr. Seed? I'm doing well Carl. Thank you for having [00:56:00] me on your show. Yeah, you talk about some some awesome awesome peptides. So but I got to say something. I mean if you look there's a there's been a lot of people who've talked about peptides before but I don't think many people are doing.

[00:56:15] What you have done? No. No, I got to give you credit for something, right, you know, I mean, we all know that guys like that be true. I mean they they really were the fire carriers early on and they taught all of us things. But but what you have done in a ridiculously short period of time is helped launch the international peptide Society because you saw that this was.

[00:56:42] Not only viable way to help people but an untapped way to truly help people in different types of categories of conditions. And and you realize holy men. This this is this is going to end up becoming like a three-ring circus [00:57:00] if we don't get an organization together led by leaders in each of their on their different continents and and put some things in place.

[00:57:11] Otherwise this will become snake-oil really fast and and IPS is exploded in popularity. I know doctors who I'm having conversations with them about other things and somehow the discussion of peptides comes up and it's dr. William seeds and IPS. It's like man, it's really exploded. Yeah, it's I I mean it's it's what everybody as Physicians from from our side of looking at?

[00:57:44] Why you know we went into medicine it's kind of like oh my gosh, you know now we can we can use the things that the cellular Pathways and the pathophysiology of how we understand a cell can correct itself. I mean, that's ultimately [00:58:00] we don't want to interact. We don't want to introduce new molecules.

[00:58:02] We want to introduce things the body already knows how to use to to take care of efficiency of a cell or. To treat infection of a cell or to treat metabolic issues of a cell the cell knows how to take care of itself. All all we are doing is now comprehending the fact that there are these amazing signaling agents in the body that are already there that we can take advantage of in.

[00:58:27] In helping the body do what it knows how to do and and I think that's been that's been something that we've been, you know smarter people than we have looked at this hundreds of years ago and kind of knew they were on as some things but but now we're there where we have this. Amazing amazing repository of literature supporting everyone of these peptides in issues of how [00:59:00] they can enhance intercellular homeostasis and and treat not only disease but treat aging treat repair.

[00:59:10] Restoration I mean, it's just incredible and it's so exciting to to re-energize. I think a an area of where we've known something has been there. It's just now we know how to do it and it's just you know, but don't we don't we also need to commit, you know, I'm the first person to complain about the the FDA.

[00:59:38] But didn't the FDA actually like I don't know why and how they actually got this one right because they have kind of opened the gate to what is now becoming Physicians prescribing and treating patients with peptides. They were like, you know, okay and this and if you would have bet [01:00:00] me a year ago that the FDA would have even just got out of the way I would have said no you're wrong.

[01:00:05] They're not they're never going to do that. How did that happen? Yes. Well, I mean they're there and they're not there. So so we'll take where there were there and we'll move forward and we'll bring them back hopefully with real science real with with real. Clinical evidence on on how these things work and why they work and that's what that's the best part of this is that we've gained significant amount of ground.

[01:00:33] This is worldwide there 500 clinical studies in place to go right now. I mean, that's that's incredible and more. So in cancer, you know in oncology and metabolic disease. I mean, that's where it's highlighted. So. It and it's in every Silo of medicine and it's because it all makes sense. I mean a lot of these things that were working against in in life, you know cancer and [01:01:00] aging aren't too far apart.

[01:01:02] The cell doesn't differentiate too much there. It's just a little thing goes wrong and you know, the cell goes the wrong way and that's what it comes down to and now we have you know, we have the capability to show the world that he guys were working. Where you want to be, you know because this is this is moral in a working in a process of treating things naturally.

[01:01:26] Like they should be instead of like I said implementing harmful molecules that can wreak havoc even though they can do things. They have significant and serious side effects. So it's understanding these Pathways. It's understanding how we can use these. In the right path in the right place at the right time and and that's what's happening right now.

[01:01:46] And there's just a surge of people wanting to learn these processes and what's available and and the other part of this call that I think is really interesting is now, you know, a big Pharma is on top of this now [01:02:00] for sure because they're the ones introducing these new GL p dash. Are receptors are grp receptor Agonist, which are there basically integrins that the small intestine makes and these are turning out to be incredible diabetic.

[01:02:21] peptides and and they saw the opportunity to not to have to recreate the wheel they solve the the the benefits and so the Rd was much less expensive. They went down that road and now we've got some amazing G. P receptor Agonist that are out there now, you know like Victoza and some other very well known diabetic drugs that are going to change the market for sure because they're good peptides and they're doing good things.

[01:02:55] And so so that's just the beginning so when you've got that Marketplace changing like [01:03:00] that, I mean. Honestly, you know we work against big pharmaceutical companies but they sometimes can make things work in our favor to so so peptides are you know, it's all it's exciting. It's changing in. This is funny.

[01:03:15] You know, I always tell people like doctor seeds, you know peptides are just started. You know, this is new. It's it's great that that we're just getting on top of these of understanding what a peptide is and I'll tell a doctor. Will you been using it for your whole you've been using this in your.

[01:03:30] Practice since you started. Insulin insulin is a peptide. It's one of the most famous things that we've that's been developed a Nobel Peace Prize was given for the development of insulin and then all of the research that went into looking at insulin and then oxytocin and gonadotropin-releasing hormone and vasopressin saw all other peptides it started as storm of information.

[01:03:55] So yeah, I mean to answer your question. It's exciting. It is exciting [01:04:00] and I'm glad things. There's plenty of pharmacies now that a capable of filling these prescriptions, which is really exciting because now doctors can stop prescribing. So we're going to talk today about a little-known peptide and its value some of the early research that that I bumped into show that it has a potential benefits the people who suffer from autoimmunity especially diseases like rheumatoid arthritis.

[01:04:25] I've experimented with it. I'll talk about my own experience with it. It's called LL. 3:7 what is LL 3/7?  All right. Well, so LL 3637 is a what we call a capital S attention. That's a capital S it in there defensins and there are things called catholicity ins and a capital asset and is what it's a natural.

[01:04:55] Peptide that the cell makes in the human [01:05:00] body to fight off microbial bacteria viruses fungi - even other cellular entities and parasites and your your body makes these peptides. To fight off infection and it's been something since since the time of the human development. It's been there forever. It's an innate immunity.

[01:05:28] It's the first line of defense that a cell has and this capital S it in LL 37 is it's the only one that humans make they make one Capital asset and it's LL. So and what's interesting is actually this is a this is a capital asset and is a 37 it trance. It's trans transgresses through species and plants like plants and animals make LL [01:06:00] 37 interesting.

[01:06:01] Yeah, it is it really is and it's so it acts like a broad-spectrum antibiotic. Basically. It's an antiviral. It's an antifungal. But it does it does it and I guess I should have said this earlier but it does it differently than an antibiotic in that the antibiotic is actually a molecule if you will and the LL 37 is kind of a message, you know, the peptides are amino acids in a certain syntax that have a meaning that when they show up at a cell.

[01:06:37] It held its giving peptide your information. They're not molecules their messages. Yeah. Well and that's a that's exactly so so it in a short answer to what you just brought up. Basically what else 37 can do is it can take a natural? Let's say we have these things called mast cells mast cells [01:07:00] are is an immune cell and.

[01:07:02] The mast cell has a receptor on it like an antenna that's always looking for bad stuff in the body and what LL 37 can do is it can upregulate that receptor to be at a heightened alertness for an infection or a virus or anything and it what it does. Is it up regulates its response to enhance those.

[01:07:32] There's two other types of mass cells. That's just a basic basic premise there but it there's a lot of things that it will influence the macrophages and influences the neutrophils and influences cytotoxic T cells. And so what it does is it helps what it has an activity where it can. Cause pouring like through a membrane of a bacteria or a [01:08:00] virus where it can actually cause a this molecular reflux into a cell of a virus or you know bacteria, right so it can actually destroy it so it's a.

[01:08:15] It's a it's an incredibly well-structured peptide. That's that's been there for ages and it works for a reason now do people when people become susceptible to bad microbes and pathogens viruses and stuff like that. Is there evidence that there is because we talked offline with via. That LL 3/7 is stimulated through sun exposure to peers.

[01:08:51] Is there evidence that some people are deficient in LL 3 7 and do we know that that's why they're more susceptible to becoming populated with with with, you [01:09:00] know, gram-negative bacteria or fungi or viruses and stuff like that. Well, I think that might have to do more with. With something where.

[01:09:16] so it actually vitamin D can play a significant role in working with activating LL 37, right? So so that I think that's where that issue comes more into play is the vitamin D influence on LL 37 when you talk about the sun stuff, but but again L 37 is everywhere and it can so if there's it can react to damaged tissue from UVA UVB light UVB it can I mean they're so what's interesting about LL 37.

[01:09:54] It just doesn't. It doesn't just [01:10:00] have a response specific to like a virus or antimicrobial it has it actually has what we call these PA MPS and da MPS which is a. It's basically a pathogen Associated molecular pattern meaning it can be the that microbial can be that pmap, but you can have damaged tissue which is called a dmap.

[01:10:33] That can be enhanced by L 37. So that's where the immune system gets into play here were actually, you know, LL 37 can work against the body to it some points. I mean you can upregulate that immune system where it's attacking itself and that's where you get into. A lot of I think brilliant research that's going on right now involving and looking at L 37 where you [01:11:00] see upregulation of LL 37 in some and certain autoimmune diseases.

[01:11:06] Like lupus and and and in some instances rheumatoid arthritis and and and other diseases like that autoimmune disease is Ella 37 can be upregulated. So it's gone to its to act but wait a minute. What was the sees this is this is why I get confused about this Association or correlation versus causality, especially in this type of discussion.

[01:11:31] So. There is a lot of good research out there. I'm just going to talk about a different but similar peptide and that is beta amyloid right beta amyloid is a powerful antimicrobial, right and beta-amyloid obviously is implicated its presence and its accumulation. Inappropriate accumulation is is associated with Alzheimer's disease.

[01:11:58] Right? And there is a [01:12:00] body of evidence out there that the body is producing beta-amyloid not as a malfunction, but as a trying to remedy a problem in the brain, all right of that requires its antimicrobial activity, right? Well, well that beta-amyloid that structure is very similar to L there.

[01:12:17] Right? Well, that's why I'm so so what I'm saying is now we're starting to go. Wait a. Beta amyloid is increased in that Alzheimer's model. Yeah, it's its corollary. It's not causing the Alzheimer's disease. So why do we automatically assume that the reason that LL 37 is present in high amounts is actually exacerbating the rheumatoid arthritis arthritis.

[01:12:42] Maybe it's just failing. To do what the body wants it to do and so keeps up regulating more and more and more. So it's not causing the problem. It's trying to fix the problem sure and that's the great debate. And and actually that's a very true liking like cystic fibrosis. Here's a perfect example.

[01:13:00] [01:12:59] I mean we know through significant amount of literature that in cystic fibrosis in that mucus there is a significant upregulation of LL 37 and you. Make that corollary of oh gosh. They're there that LL 37 is causing a problem in cystic fibrosis. It's causing all these issues, you know within the fibrosis in the issues within the lungs but what actually happens is that L 37 has been upregulated because it can't be activated because what actually happens is.

[01:13:33] There is a these glycosaminoglycans that actually Bond LOL 37 and don't let it be activated. So it builds so what we're finding is if you can go in and break that glycosaminoglycan Bond. Then all of that LL 37 can be activated and do its job in taking care of the microbial issue. So so you're right on track and actually the brain [01:14:00] stuff.

[01:14:00] You know, that's one that's one. That's one researchers theory is that that is the issue. That's just one person. I know and so there's a lot of great debate about it. I will tell you. That I think it is a reaction. I think it's it actually goes a lot deeper it has to do with with this thing called an inflammatory sewn in the in the cell that responds to making these.

[01:14:32] Plaques or Lewy bodies or anything you want to call them because it crosses it crosses all dementia. Alzheimer's multiple sclerosis Parkinson's it's all very very similar when you get down to the cell level of basically misfolding proteins on the on the backside of metabolism and how how the body responds.

[01:14:55] To making these plaques and but we're jumping way ahead with this L 37. [01:15:00] But yeah, it's really interesting when you look at this vast amount of literature, but it all makes sense. I mean it definitely all makes sense because L 37 is an anti-inflammatory, but it's also a pro-inflammatory, right? So so you have to respect what's makes me think that it should be taking taken with things that we know are resolved ins, but that's just it, you know, I so let's talk about.

[01:15:23] LL 37 now from a clinicians point of view. Yes, where would a clinician see a potential use for LL 37 with a. Sure. Well, I think you know the considerations of mean again here is a great natural antibiotic that that doesn't cause any resistance. It's interesting. If you you want to get down to something that this I think fascinating is, you know, when you have infections or viral infections these viruses and bacteria can make a cell [01:16:00] manipulate a cell so.

[01:16:01] When it sees an antibiotic coming it can adjust the immune system to defend against something that typically it would be rendered. It would be killed but with LL 37, it actually works with the intelligence of the cell understanding that the bacteria or the virus or something. Maybe trying to manipulate that.

[01:16:28] You know that immune system. So so it's really interesting. If you look at it that way that I like it. It's your it's a natural, you know, you're helping the cell think through the issue if I can say that right and and so you know for just I think for people that have. That have drug resistance, you know that have a gram positive gram-negative.

[01:16:54] I mean these these these this L 37 has been shown to be more effective [01:17:00] than than some of these cycle cefazolin or clindamycin or doxycycline and treating intercellular staff. So it's a it's an excellent. Choice, if you're looking at it, I think it number one microbial resistance number two for chronic infections, you know, chronic bladder infections cystitis issues chronic kidney issues.

[01:17:31] And we we can even make us the you know, go into the the issue about the gut and I want to I want to take a break and when we come back I want it. That's why I want to pick up my personal experience of I expect I've experimented with LL 37, and I had a noticeable. Change in my digestion. Oh, that's always trouble Carl when your experiments.

[01:17:51] Yes, of course, you know that so we're going to take one quick commercial break. If you want to learn more about the peptides is international peptide Society go to [01:18:00] peptide society-dot- org. If you are a clinician, you can become a member they will train you. They have all sorts of lectures doctor seeds travels all over the country lecturing on.

[01:18:12] The appropriate uses of Novel peptides check that out. We'll be right back with more superhuman radio stay tuned. Welcome back. We're talking with dr. William seeds from the international peptide society that website website is peptide society-dot- org. We're talking about a novel peptide called LL 3 7.

[01:18:30] It's not a not a muscle builder, but it has a place for people who are concerned about health. And so I experimented with it. I. I went to my friends over at peptide sciences.com and I got some LL 3 7 and then I reconstituted it was a 5 milligram vial and I basically took a hundred 25 micrograms once a day [01:19:00] for about just about a week.

[01:19:01] It wasn't very long. In fact because some of the information I read about its accumulation in. Ideologies of certain disorders made me go. You know, this is this is something that you can't like just over do you just need to use the right amount? And so I did it for like I think I did it for a week five or six days and then I had to go to Atlantic City for my cousin rosemarys 75th birthday, and I don't eat bread.

[01:19:31] I haven't eaten bread and years because if I eat even the smallest piece of bread on my my gut blows up like the Jiffy Pop. Popcorn lid and I'm bloated and I'm gassy for hours. I it's uncomfortable. I actually ate bread.  And it didn't bother me and I thought to myself could that be the LL 3 7 to the L3 7 change the landscape of my gut that quickly and just six days.

[01:19:59] What [01:20:00] do you think? Absolutely and that's some exciting that's some exciting areas of where? We're looking at the use of LL 37 and got health and especially if we could go into much more detail with other peptides but in specifically I mean we know here's a couple things we know we know that this protects the intestinal barrier against pathogens that.

[01:20:32] Meaty, you know that cause inflammation. I mean we know that okay, so, you know that occurs in the bowel with some certain overgrows if the micro if the microbiota is not in, you know homeostasis, there's issues like that and we know that LPS these lippo polysaccharides are increased and these things can cause damage.

[01:20:54] Well L 37 actually blocks the interaction of what we call this [01:21:00] toll-like receptor 4, which is. That antenna I was talking about that grabs onto this LPS and start signaling the rest of the body. Hey, we're in trouble. Well, Ella 37 actually blocks that. So you're you're and a down regulates these cytokines that respond in the bowel to you know, things like interleukin 4 and tumor necrosis Factor Alpha and there's a what else interferon?

[01:21:29] Are looking 12 a bunch of these things that cause you know an inflammatory cytokine response so it down regulates that that's an amazing amazing tool we can use now where we have people that have leaky guts. If you want to call it or a dysbiosis of the microbiome, and we can actually work on correcting that.

[01:21:55] With you know as we try to get someone's diet and and [01:22:00] and that process intact we will we got something actually that goes right to the root of the issues immediately. And so that's why you saw some of these things happening so quickly because you were actually you were affecting that toll-like receptor.

[01:22:14] You were blocking LPS binding you were improving you were helping to protect the intestinal barrier against those pathogens. And you were down regulating your inflammatory response immediately. I mean immediately so. That's a pretty powerful thing. And at the same time you're not using an antibiotic that's wiping out all the good bugs in your stomach your your you're working with the microbiota to help improve that human estate that homeostasis.

[01:22:47] So there's so many amazing implications with this peptide in in treating, you know dysbiosis and issues. What about sibo? So what about the it appropriately, you [01:23:00] know placed microbes in the small intestine. You think LL 37 has a role in that as well. Absolutely, and and I mean I think C vo, I mean there's lots of theories out there but sibo is you know sibo is it's a small intestines microbes.

[01:23:16] It's microbials that migrate from the large intestine into the small intestine or or they're introduced. I think there's there was an excellent paper that came out just recently that that brought up this premise of hey guys, maybe we're doing the wrong thing with probiotics. I was with doctor says satis Rao he was on the show.

[01:23:38] Yeah, that was that was amazing paper. Yeah, I mean the guy and the Deep the D lactic acid build up because that's produced in the gut was evidence that what he was saying was actually happening. But you know, the only and I communicated with him the only the only answer that would he use was I've axon which is a which [01:24:00] is.

[01:24:00] A very old but very expensive antibiotic because usually just take one or two of them if you have diarrhea when you're in Mexico. Yeah. No. Well, here's here's an well, I'm just giving you an idea. Yeah, you're here something that you you can actually you can actually help people with something like that and at the same time get them right with I mean, that would be an amazing paper actually to find out.

[01:24:27] You know because the world's gone Bonkers on this, you know, you know my stance on probiotics, right? I would love I would love to follow up with that with that train of thought because it's I think it's all the Prebiotic and not the probiotic. But anyways, well, no. No I look I'm with you on this.

[01:24:45] So I've come to the conclusion that. More fiber is part of our problem today. Absolutely. I mean all look at look at our distended stomach. So we're starting to look like Australia piscis robust this again, you know Carl show me I want [01:25:00] to see the study that shows me that this that the probiotic actually gets into the large intestine and does what it's supposed.

[01:25:07] Oh, no, they already know that they don't you know, what? Do you know how they I know that because there is a drug company working on a Frozen. Probiotic that they they go to the extent of showing that it doesn't get delivered until the the large intestine and so they ordered everybody already knows that they're not doing any they these aren't getting where they belong they're getting they're getting delivered Way north of where they belong.

[01:25:34] Well, yeah. I mean we could go into some amazing. Discussion about this but that's and that's another area where we're finding new peptides actually buy that are made by your natural. Microbials in the in this large intestine were that's just opening up a whole nother Gateway of you know, the gut brain axis and and what happens with some of these peptides that are produced [01:26:00] in healthy situations and in an inflamed situations where we can you know, that's the beauty about peptides we can find an area of.

[01:26:10] Of injury or where something's going wrong. We can design a peptide that can go to that area and it can either conjugate chemo therapeutic or a viral antiviral or anything to bring to that area to take care of the problem. I mean that's kind of in a nutshell how exciting this stuff is getting. So what is the dose that you see?

[01:26:36] Huh hundred micrograms. Got it, honey. Yeah hundred micrograms a day. And that's either, you know, I would never My Philosophy and thought on this is never go over a six-week timeframe with it and just because I don't want to go down that road of it of of up regulating this innate immune system of having the body, you know [01:27:00] get to upregulated.

[01:27:02] And and again, I mean we're continuing to learn more and more about this and there's some very very bright people working on this right now, but I think that's the best way to stay out of trouble and in any in any event for just typical chronic infections, I think most people are are doing well with like two-week regiments and and when you're but when you're treating dysbiosis and things in the bowel, that's where you're seeing people they're using up to six weeks of treatment.

[01:27:31] On top of some other ways of of improving the bow but and and I'll tell you that the the the hidden aspect or one of the Hidden Treasures. I think of all 37 is it's also an amazing antifungal and a lot of people that have issues with dysbiosis is about. Also have fungus infections that they're that they're not addressing and [01:28:00] the nice thing about L 37 is it's that it also attacks the cell wall and it Alters the DNA of the fungus so it can't replicate so it does this this is this fungus anywhere in your body or just your anyway anyway, anyway, anyway anywhere in your body anywhere in your body?

[01:28:19] That's it. That's amazing. I mean, look at this, you've got something that treats gram-negative gram-positive viral infections fungal infections, and it's but it but doesn't it make sense. I mean the body is, you know, the body has developed something that. That has been there for forever. I mean there's a reason it works.

[01:28:44] Right? Right. And so really all we're doing is supplementing with it with with some reasonable precautionary approaches to it and length of time and so do you see people who. Or any of the Physicians [01:29:00] you've trained we're now using LL 37 successfully and saying, you know what I had this patient that presented this this and that six weeks later all gone.

[01:29:09] Oh my gosh, really mean? No just the. Just the I mean The Chronic, you know the chronic UTIs. That's a biggie. What about what about prostatitis? That's a bad thing? No, yes. Yes. Yes. Yes. Yes. Well, that's interesting you bring that up. So lots of we could get into significant debates about that, but I think.

[01:29:38] How do I discuss this? Yeah, so so if you're inclined to you know, depending on the patient and the treatment and initial insult of why the potential of of prostatitis you can look at this a couple ways from the immune side and this is where LL [01:30:00] 37 and like Simonson alpha-1 together can can work in synergy.

[01:30:07] In helping patients with prostatitis and and significantly reducing that the that process now, I can't say that, you know here at the issue is are you curing people? Are you stopping these things? Are you and I think what we're seeing is we're creating an environment of where we're creating less recurrences.

[01:30:32] Yeah, I don't know if we're eradicating anything yet, but I can tell you for fact that you know that we're seeing absolutely less recurrence. That's and that's a price. That's a big deal right there because he's poor guys are taking antibiotics and stuff like that. God Yeah Carl, it's a it's a tremendous step forward where where we've just got it's just another tool in the [01:31:00] toolbox to you know to work and trying to instead of hurt the patient.

[01:31:05] We're helping the patient and that's what's exciting. You know any other exciting peptides on the horizon that you want to kind of bring into the discussion. We've only we've only got like 15 minutes left in the interview not you're laughing because it's probably a ton of them, right? Yes. Yes.

[01:31:19] Yes. Yes. Yes, but what's give me give me give me give me something really meaty. Give me something great for the audience. Okay.  well. Okay, so so here's something that'll I think a rock the world. There's been some so when we look at a cell. And we look at a cell and how it responds to stress and stress meaning aging or disease.

[01:31:58] It's the cell sees it all is the [01:32:00] same. It's a stressor. So typically a cell evolves right by by developing a way to deal with the stress. So so actually a cell needs a little bit of stress. To become resistant to the next set of stresses that are going to come. And it makes sense. If I compare that to your world out there of you know, the guys training hard and working hard who take like antioxidants.

[01:32:33] It's kind of not the right thing to do because your cell actually needs those you need that inflammatory response to to rebuild. Okay, right. So so it's along the same lines in that fashion, but the cell needs this response. Well, we know that the what's really amazing is you actually. Cell have two different genetic these two different genomes.

[01:32:59] The [01:33:00] mitochondria has its own genome and the nucleus has its own genome and this goes back genome. It goes back to evolution of how bacteria combined with you care site. How we've developed in a symbiosis with something that came from bacteria and that is the mitochondria. So we've got two genomes that actually have to talk to each other to make the cell work.

[01:33:25] Well what happens is and it all comes down to mitochondrial function way one way or another as we age or fight disease where. It creates these your mitochondria just has so much it can do to react to this stress. Okay. So so what happens is we've had these theories that there have been this upregulated response from the nucleus that sends these signaling proteins like over a thousand of them to the nucleus are to the mitochondria [01:34:00] to help it.

[01:34:01] Manipulate through the stress periods and to keep things moving. Okay. So what we've learned is actually now the mitochondria makes a peptide called motc s that goes back and tells the nucleus. Hey, this is what we got to do, too. Rectify the situation. Well, what's fascinating is we have found that these centurions that from like Japan and Okinawa if you look at their genetic makeup, you can see that they've made an alteration in their genome of where they produce this peptide.

[01:34:49] It's oh yeah. Yeah, and it's fascinating actually. Fascinating so in studying this peptide in if you can up [01:35:00] regulate this peptide at least in in animal studies, you can correct not just treat you could correct insulin resistance. You you improve all of some of those early basic things that lead to you know, the degradation of a cell, right?

[01:35:17] This is unbelievable. So what you're saying is you can actually reverse cellular senescence or slow it down.  So well, you can't reverse it. So once a cell is in senescence, you can't okay tough thing because it stopped it's stopping its it's stopping its phase changes. But what you're going to do is you're going to you're going to help the other cells from going into sense.

[01:35:44] Yeah, because and that's the big problem right now that we're learning about the. Like the decider nib study and even some of the rap along studies that if you can get rid of the. This is this senescent cells. They stop the good cells from joining. Oh coming crossing over becoming [01:36:00] senescent as well.

[01:36:00] Well, what happened what really is happening is that so you need you need proper a topology you need it's like the clean up crew that comes in and cleans up a cell. That is what this does is. It improves the topology to clean a cell up so it doesn't get into a senescent state so it and and it's these senescent cells that.

[01:36:21] Break down. They create they create the environment for the you know, more of these reactive oxygen species that your cell can only do so much to treat so so yeah, it's a this motc - s is the real real deal and I'm going to tell you right now it's going to be it is the peptide that is coming that is going to I think change the world and there are a couple other ones that are.

[01:36:50] That are in the in the same line that are already being done and I will tell you I can I guess I can say this we have [01:37:00] one of these in an IRB right now that we're utilizing that is similar to the motc - s that is it's a game changer. So so we're looking at things that are going to affect neurodegenerative disease.

[01:37:15] But also just aging I mean, I mean think about that. I mean we've isolated you're going to tell me we've looked at the Genome of a specific subset of a population and actually shown that this is what they are doing at the cell level that has separated them from everybody else. It's not about diet.

[01:37:34] It's not about this. It's what their genome has sequenced this peptide and it's this response to its this upregulation of this motc ass. To stress and the cell adapts and it creates that environment of of homeostasis within the cell. So I mean, that's it. Very exciting. Yeah, it's crazy car you are you guys are [01:38:00] you guys going back and looking at some of the stuff that the Russians put forth that no one is no one is agreed with and kind of either debunking like the penal on and the epital on you know, all that.

[01:38:11] I actually tried to get. Russian scientists on the show and because his English was so bad. He didn't want to do it. But you know those those penal on those those those small peptide three and four amino acid peptide the Russians claim. That's where the magic is for anti-aging. What do you think?

[01:38:33] I'm totally so so there there you're talking more about what we call regulatory peptides. Okay, three peptide sequences, right? And actually dr. Kevin assassin who is who's the runs that Russian Institute, you know, he did all the pioneering work on Epi Talon and fi m'lynn and the guy had over 25 years of data just showing, [01:39:00] you know 10-day treatments twice a year with a battalion and and final inand showing decreased mortality now.

[01:39:09] You can make all the arguments you want that maybe they weren't presenting things appropriately are you know, they weren't following protocols or all I'm going to tell you is they got 25 years of data and then the ukrainians through a different Institute repeated their work with some similar dosing schemes and repeated and showed the same.

[01:39:32] Type of issues of decreasing mortality and decreasing incidence of cancer and even using in cancer patients so so I don't think we can turn our we can turn a blind eye to what they've done and and even more so when you look at these regulatory peptides, they're completely non-toxic type of rap tides and and I would just put it this [01:40:00] way, you know when and.

[01:40:02] If you have the ability to utilize and understand their protocols, I don't want to be somebody 25 years from now thinking. Oh my gosh, why didn't why wasn't I utilizing some of these protocols that I know? You know, they've shown the data now it all comes down to some people arguing. Well, you know, this doesn't work this way because the way it was potentially presented.

[01:40:30] Well, I think those are our debates but again, I'm just going to say, you know until you show me some other data. I've got some stuff that basically has been built right on his on his pioneering work. And in fact, I'm going to Russia in. With a group of people in in April. To actually meet and discuss some of these issues.

[01:40:57] We're were we're very [01:41:00] attuned to what they've been doing. And we're hoping to that we can learn more from from their approach. You know, it's all about getting information right Carla mean you're you're the master this and you bring topics to people that no one brings and you're awesome. It just asking questions.

[01:41:20] Well, guess what we do the same thing. To ask questions. It's about learning and Ryan. I just don't think you can ever not consider other Alternatives or other ways that people look at these things now. The more information we have we certainly can make better decisions. Right? And and that's what we need.

[01:41:44] We just need more information so we can all make better decisions. No, I agree. That's exciting. So I do you have any upcoming lectures where you'll be speaking or doing any certification programs? Yeah. I'm in Vegas here in December where I'm [01:42:00] running one day workshop for docs for for peptides and then I'm running a four day.

[01:42:08] Completion of the first group of it's about 250 Physicians that are have been working for the last year going through a certification course, that will be finishing up in December. Yeah, we all know we have a busy busy schedule their that Physicians who are listening to the show. How do they join IPS?

[01:42:31] And what is that? What is if they join what does it give them access to? Hmm well and thank you for asking that so this is a platform of information with webinars literature all the current literature on all of the on more to peptides that I feel people want to know more about like about 60 of them or so that we've have a repository of over [01:43:00] eleven twelve thousand articles blogs.

[01:43:04] We have an open discussion of of just trying to integrate this information for to make it understandable for Physicians and to to set up a platform of where we can ask questions and learn from each other. And I mean, I just I just got back from we ran a mastermind course and in New York City where we I got a couple of the who I felt were some of the leaders in peptide therapy's around the world.

[01:43:32] And oh my gosh, it was just amazing to sit down with 20 of the smartest people. It's humbling really and and where we sat for two days just talking and it was it was it was mine. It was mind-numbing yard to to actually. Coralie, and and and and discuss really in-depth things. You just can't do in big open lecture.

[01:43:59] I know [01:44:00] right and and I can tell you now. I just got to God. I just got to get all you same guys in this in the room and then I bring the micro dose of LSD and really stuff will start happening. Then we'll be able it will be able to see into the future of peptides that right inside Abbie Hoffman.

[01:44:16] Here we come but. This is this is great. This is really good information. The website is peptide society-dot- org. If you're a physician clinician, it's actually Carlos International peptide Society, right or is it is that the site and no yeah International peptide Society is the is the name of it, but your actual URL is peptide society-dot- org.

[01:44:38] Oh, thank you. Okay. I didn't know that. Thank you. No, that's okay. Yeah and people can go there and join you can also find the clinic. In your area if you're somebody who's looking to engage a clinic that is forward-leaning and working with peptides ready. You can find a clinic there. So this is the you find a good physician [01:45:00] and this is where it all starts.

[01:45:02] This is exciting. Nobody has to be afraid of peptides. They're not doing any harmful things to people. You can take stupid doses of them. I mean not insulin, but but no, you know, it's like it's finally it's something that doesn't really have the actually find something that fits the Do no harm, you know Edict of Hippocrates, you know, so it's exciting stuff.

[01:45:28] Thanks for making time to come on the show. I know you're a busy guy. Well Carl, I just you know, every time you give me a chance to talk, you know, I'm going to throw it back at you and say I just appreciate everything you do for us for me for stimulating me to take the next step to keep questioning myself, you know, as a as a as one of those Physicians out there that.

[01:45:50] Feels it. I always need to learn you definitely give me that that excitement and looking and trying to get better at [01:46:00] things and and it's people like you that are the ones who are changing the world because you are asking the questions you are the one looking at things that other people don't look at maybe in the same way, but you stimulate fought in a different way.

[01:46:14] And that's an amazing gift and I can't thank you enough for what you've done to help all of my people and my patient. Thank you so much. Thank you so much straight. Take care. We are going to also say goodbye now and boy, that's a that's a touching that he said that I.

[01:46:34] I never get used to that. Anyway, thanks to coach Rodriguez. For the blueprint power our check out his website coach Rodriguez.com and I will see you tomorrow with more superhuman radio. Thank you for listening

[01:47:00] [01:46:55] today

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