Joel Greene

If you believe the science that declining levels of Nicotinamide Riboside is the reason for advanced aging, then is't the logical question "why dose it decline?" No one in the NAD+ space seems to ever explain that. CD38 would be the answer. So, if CD38 is causing the decline in NAD+ why aren't we focusing on that?

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SHR # 2364 :: What Is The Reason For The Decline in NAD+ As We Age?

Show Notes:

CD-38 is at the center of the killer:healing macrophage problem. One reason for this is that it inhibits NAD+ to ADPR.

[12:30] Joel discusses the history of NAD+

• Nicotinamide riboside is the secondary pathway that the body uses to create NAD+.

[14:50] There are numerous ways to replete NAD+

• The first big step is sleep. Diurnal rhythms and NAD+ have a codependence upon each other.

[17:25] The nature of REM sleep.

• Dream sleep is much more important than we previously realized.

[18:15] Butyrate production will also increase NAD+, but you do not want to supplement with butyrate products.

[19:45] The big picture of NAD+.

• The more CD-38 that you have, the more NAD+ you will need.
• NAD+ band aids the problem but does not fix the underlying problem.
• You will need to lower CD-38 in the body.
• There is a gut link to CD-38.

[22:20]  The problem begins with the oral cavity and gut.

• Healing macrophages get overwhelmed by inflammatory macrophages.

[26:00] The myth of gut bacteria diversity.

• Lack of bifido spawns several problems in the body.

[34:08] Joel’s brother was in horrible shape from Parkinson’s.

• Joel focused on rapidly repopulating his gut. He supplemented with Bifido along with milk immunoglobulins.
• The problem with probiotics is that the location of their release cannot be controlled..
• They also do not possess the special properties of whole foods.
• Joel’s also drastically increased his brother’s sleep.
• If your stool smells horrible, your gut is in bad shape.

[45:35] How to actually repopulate bifido in the gut.

• We are diurnal creatures, and the timing of nutrition matters.
• During the morning, certain fruits such as bananas, grapefruit and other dark polyphenols serve as substrate for bifido.
• Starchier substances, such as garbanzo beans, are preferred later in the day.
• In the evening; cellulose type veggies such as broccoli and cabbage should be eaten, preferably raw.

[48:10] How selective gut layers work.

• Butyrate orves to be crucial.
• Macrophages underly the villi.
• Butyrate is the signal that tells macrophages to allow passage or to attack.

[56:00] Dairy products are addressed.

• Joel feels that the negative stigma around dairy will shift direction soon.

Show Transcript SHR # 2364 :: What Is The Reason For The Decline in NAD+ As We Age?