Method Rejuvenates Multiple Cellular Attributes by 30 Years-New Study

[00:05:48]   Why this study?

• The method is based on stem cell reprogramming.
• This is a phenomenal technique where almost any cell in our body can be converted back into a stem cell.
• It requires four genes (Oct3/4, Sox2, Klf4, c-Myc) to be expressed known as the Yamanaka factors.
• By activating them in a body cell, it triggers a series of events that eventually leads to the activation of the pluripotency program.
• This rejuvenates the cells to an almost embryonic like state effective, but you lose your starting cell types, so you do not have the functions you had.
• We were very curious if we could harness the rejuvenation from this reprogramming approach, but still keep our starting cell type and therefore keep the functions in a more useful form.

[00:11:56]   Could the cells you were working with become cancer cells?

• By effectively avoiding going into full pluripotent state, we should be able to avoid the risks of cancer

[00:12:42]   Dr Diljeet eloquently explains how the study was conducted.

[00:17:00]   Carl shares his view on telomeres, senescent cells and iron carrying cells.

[00:22:00]   Carl elaborates on epigenetic testing and Dr Diljeet replies to Carl’s questions about epigenetics in relation to his research. A must listen!

[00:34:33]   With age oxidative stress does increase, this is something that reprogramming has the ability to reverse.

[00:35:15]   How much of the reduction in collagen production could be dietary?

• It definitely will cause signaling changes and with collagen being a protein, you do need the amino acids to construct it.
• By eating less protein, you are going to be producing less collagen.

[00:38:00]   Dr Diljeet explains various hypotheses when rejuvenating cells in optimal and sub-optimal environments.

[00:43:14]   What do you think about sun and aging skin?

• There is no clear consensus, the sun might be beneficial but have harmful effects and it depends on the individual and circumstances.
• There is literature comparing sun exposed skin cells to non-exposed cells and there were some differences, but the sun is important for Vit D production.

[00:44:09]   Carl shares his view on Vit D production and the Melanocortin system and sites some interesting facts on Melanotan II.

[00:49:00]   Do growth factors play a role in helping these cells become more youthful?

• The rejuvenated cells will be producing growth factors that influence each other.
• Still investigating the signaling of the cell molecules.
• In the reprogramming process the cells are exposed to fibroblast growth factor 2, experimenting to see if that in itself plays a role in the rejuvenation process.

[00:52:12]   What do you hope clinicians and lay people take away from this study?

• Main message is that we have developed an exciting method which harnesses the rejuvenation from reprogramming, but still keeps the starting cell type.
• This could be exciting for treating skin conditions in particular, but in the future, even broader.
• The overarching future goal is to determine if we can replace the reprogramming genes with actual molecules that we might be able to give either in the form of a pill or nutrition.

Let's Talk SKIN

[01:02:32]   What role does nutrition play in the quality of skin as we age?

• Nutrition affects your organs and how you absorb food and nutrients.

[01:03:34]   What do you think about polyunsaturated fatty acid?

• They are definitely inflammatory.
• People consume way too much omega 6 and not enough omega 3.

[01:04:39]   Can you tell us anything about liver or age spots?

• Too much sugar and the wrong types of fats contribute to the forming of these spots.

[01:05:58]   Restoracell moisturizer has been reformulated. Oils have been rebalanced to absorb better and added more GHK-Cu peptides.

[00:53:36]   What are some of the worst things people do that hurts their skin as far as diet goes?

• People do not realize how much sugar they actually consume, which creates huge damage through inflammation and gut health.

[01:10:59]   Mary shares her experience with Restoracell.

[01:15:09]   Mary elaborates on what she sees in people’s skin most often after they have not been doing the healthiest things.

[01:19:05]   Both guests and Carl go into detail on the advantages and significant changes Restoracell, and GHK-Cu brings about (see link below).

[00:21:09]   Mary reiterates how important exercise, optimal nutrition and supplementary treatments like sauna are for the skin.

Restoracell
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