STUDY: COVID-19 and Chronological Aging: Senolytics and Other Anti-aging Drugs for the Treatment or Prevention of Coronavirus Infection?
with Guest Dr. Michael Lisanti, MD - PhD
Many of us in this audience already use senolytic agents to help push back biological aging. Are these strategies helpful in protecting against COVID-19 as well? Is there a difference in the death toll of those who are chronological 0ver 60 years old versus a 65 year old person who is biologically 40? And what of time restricted feeding? It imparts some of the same benefits as senolytics. We learn the answers to these and more on today’s show.
study link: https://www.aging-us.com/article/103001/text
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Show Notes:
STUDY: COVID-19 and Chronological Aging: Senolytics and Other Anti-aging Drugs for the Treatment or Prevention of Coronavirus Infection?
[00:01:53] Dr Michael explains why this study and how it came about.
[00:05:05] Azithromycin and Doxycycline falls into the antibiotic class of drugs. Rapamycin was originally also classified as an antibiotic.
[00:05:37] Dr Michael shares his view on mTOR inhibition and drugs like Resveratrol, Quercetin being senolytics.
[00:07:12] The discussion continues on to dosages for Azithromycin for Covid treatment.
[00:09:00] Dr Michael replies to a question of Carl’s regarding eradication of senescent cells, the reduction of protein synthesis and mTOR.
[00:11:13] Is there a linkage to blood sugar management and the synthesis of senescent cells?
[00:13:30] The possibility of medications like Azithromycin as prophylactics as well as for the treatment of kidney fibrosis, is discussed.
[00:17:30] Dr Michael elaborates on the uses of Doxycycline.
[00:19:00] Dr Michael describes what kills people in this particular pandemic.
[00:22:30] The discussion turns to the topic of biological age vs chronological age.
[00:27:16] Follow the conversation on time restricted feeding and ketosis and its impact on senescence.
[00:33:16] This further follows to an interesting and detailed discussion on senescent cells and the impact Azithromycin has on them as well as how it could have a significant impact on Covid patients.
[00:45:40] Dr Michael conveys a message to other clinicians in the USA and UK on his view of what tools they can use in this fight against the virus.
[00:49:23] Carl suggests a remarkable idea for a study, Dr Michael joins in – tune in!
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