SHR # 1776 :: Science For Humans: The Best Supplement Cocktail For Recurring Respiratory Infections + A Closer Look At Metformin As An Anti-Aging Drug ::

: Carl Lanore; 09 December 2015; 09 December 2015

Co-host: Dr. Jeff Golini

As the season changes the occurrence of respiratory infections and colds increases. What can you do to protect yourself and really boost your immune system? PLUS The FDA recently approved the diabetic drug metformin for the first human anti-aging trial. But is metformin really a good candidate as an anti-aging drug? Listen to all the facts and then you decide.

{mp3}SHR_Show_1776{/mp3}

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+1 # Jörgen Öhman 2015-12-10 08:35

Hi Carl,
I used resveratrol before but stopped after having read a few articles stating that it blunts the creation of satellite cells.
Do you have a take on that?
BR Jörgen

+1 # Stephen Werner 2015-12-14 15:09

It may come down to a matter of the dosage of resveratrol:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308712/

0 # Carl Lanore 2015-12-14 15:28

two things.. we now know this about all antioxidants and their potential ability to derail muscle gains and endurance adaptation.. so yes.. even Vit C does this in high enough doses. More is not better when it comes to antioxidants.. and while the antioxidant potential of resveratrol can have a negative effect on muscle gains it's not through downregulation of mTOR and this is an important one because blunting mTOR via a downreg of ALL growth factors will lead to some of the advanced aging issues seen with muscle wasting IMHO.. but yes you are right too much resveratrol can have a negative effects via the ROS pathway. Thank you for posting this!

0 # Carl Lanore 2015-12-10 08:53

I will have to look into this. Have you seen the study showing this? I'll dig for it and get back to this thread.

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